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SRR Gene

protein-coding   GIFtS: 64
GCID: GC17P002212

Serine Racemase

  See SRR-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Serine Racemase1 2     EC 5.1.1.183 8
D-Serine Ammonia-Lyase2 3     ILV12
D-Serine Dehydratase2 3     ISO12
L-Serine Ammonia-Lyase2 3     EC 4.3.1.173
L-Serine Dehydratase2 3     EC 4.3.1.183

External Ids:    HGNC: 143981   Entrez Gene: 638262   Ensembl: ENSG000001677207   OMIM: 6064775   UniProtKB: Q9GZT43   
ORGUL members:         

Export aliases for SRR gene to outside databases

Previous GC identifers: GC17P002513 GC17P002158 GC17P002413 GC17P002153 GC17P002102


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SRR Gene:
SRR (serine racemase) is a protein-coding gene. Diseases associated with SRR include serine deficiency, and miller-dieker syndrome. GO annotations related to this gene include magnesium ion binding and calcium ion binding.

UniProtKB/Swiss-Prot: SRR_HUMAN, Q9GZT4
Function: Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA
receptors. Has dehydratase activity towards both L-serine and D-serine




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SRR gene promoter:
         c-Fos   AML1a   ATF-2   Tal-1beta   YY1   GATA-1   E47   MZF-1   Egr-2   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSRR promoter sequence
   Search Chromatin IP Primers for SRR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SRR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13

SRR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRR gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P002212:  view genomic region     (about GC identifiers)

Start:
2,206,677 bp from pter      End:
2,228,554 bp from pter
Size:
21,878 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SRR_HUMAN, Q9GZT4 (See protein sequence)
Recommended Name: Serine racemase  
Size: 340 amino acids; 36566 Da
Cofactor: Pyridoxal phosphate
Subunit: Homodimer
2 PDB 3D structures from and Proteopedia for SRR:
3L6B (3D)        3L6R (3D)    
Secondary accessions: D3DTI5 Q6IA55

Explore the universe of human proteins at neXtProt for SRR: NX_Q9GZT4

Explore proteomics data for SRR at MOPED

Post-translational modifications: 

  • S-nitrosylated, leading to decrease the enzyme activity (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for SRR (Q9GZT4) (see all 6)
     LVWERMK  LEGIPAY  QKTGSFK  PSVKVYAAEP 


    See SRR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_068766.1  
    ENSEMBL proteins: 
     ENSP00000458814   ENSP00000339435   ENSP00000461589   ENSP00000461125   ENSP00000476682  
     ENSP00000461343   ENSP00000460581   ENSP00000461482  

    SRR Human Recombinant Protein Products:

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    Novus Biologicals SRR Proteins
    Novus Biologicals SRR Lysates
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    ProSpec Recombinant Protein for SRR
    Cloud-Clone Corp. Proteins for SRR

     
    Search eBioscience for Proteins for SRR 

     
    antibodies-online proteins for SRR (7 products) 

     
    antibodies-online peptides for SRR

    SRR Antibody Products:

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    antibodies-online antibodies for SRR (37 products) 

    SRR Assay Products:

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    Cloud-Clone Corp. ELISAs for SRR
    Cloud-Clone Corp. CLIAs for SRR
    Search eBioscience for ELISAs for SRR 
    antibodies-online kits for SRR (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000634 Ser/Thr_deHydtase_PyrdxlP-BS
     IPR001926 Trp_syn_b_sub_like_PLP_eny_SF

    Graphical View of Domain Structure for InterPro Entry Q9GZT4

    ProtoNet protein and cluster: Q9GZT4

    2 Blocks protein domains:
    IPB000634 Serine/threonine dehydratase
    IPB001926 Pyridoxal-5'-phosphate-dependent enzyme


    UniProtKB/Swiss-Prot: SRR_HUMAN, Q9GZT4
    Similarity: Belongs to the serine/threonine dehydratase family


    Find genes that share domains with SRR           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRR_HUMAN, Q9GZT4
    Function: Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA
    receptors. Has dehydratase activity towards both L-serine and D-serine
    Catalytic activity: L-serine = D-serine
    Catalytic activity: L-serine = pyruvate + NH(3)
    Catalytic activity: D-serine = pyruvate + NH(3)
    Enzyme regulation: Allosterically activated by magnesium, and possibly also other divalent metal cations.
    Allosterically activated by ATP, ADP or GTP. Competitively inhibited by malonate
    Biophysicochemical properties: Kinetic parameters: KM=6.5 mM for L-serine;

         Enzyme Numbers (IUBMB): EC 5.1.1.181 2 EC 4.3.1.171 EC 4.3.1.181

         Gene Ontology (GO): Selected molecular function terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA--
    GO:0003941L-serine ammonia-lyase activity IDA18812225
    GO:0005509calcium ion binding ISS--
    GO:0005515protein binding ----
    GO:0005524ATP binding ISS--
         
    Find genes that share ontologies with SRR           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SRR:
     Synthetic lethal with Ras 

         5 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Srr):
     behavior/neurological  cellular  homeostasis/metabolism  nervous system  no phenotypic analysis 

    Find genes that share phenotypes with SRR           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Srrtm1.2Jtc for SRR

       genOway: Develop your customized and physiologically relevant rodent model for SRR

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate SRR:
    hsa-miR-3140-3p
    SwitchGear 3'UTR luciferase reporter plasmidSRR 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SRR
    Predesigned siRNA for gene silencing in human, mouse, rat SRR

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: SRR (NM_004451)
    Sino Biological Human cDNA Clone for SRR
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRR

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRR


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    plasma membrane2
    endoplasmic reticulum1
    extracellular1
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA16314870
    GO:0005886plasma membrane IEA--
    GO:0043025neuronal cell body IDA17880399
    GO:0045177apical part of cell IEA--

    Find genes that share ontologies with SRR           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SRR About    
    See pathways by source

    SuperPathContained pathways About
    1Glycine, serine and threonine metabolism
    Glycine, serine and threonine metabolism
    serine and glycine biosynthesis0.00


    Find genes that share SuperPaths with SRR           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SRR
        serine and glycine biosynthesis



    1 Kegg Pathway  (Kegg details for SRR):
        Glycine, serine and threonine metabolism

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SRR: 
              Amino Acid Metabolism II in human mouse rat
              GABA & Glutamate in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SRR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SRR (Q9GZT43 ENSP000003394354) via UniProtKB, MINT, STRING, and/or I2D (see all 100)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IARSP412523, ENSP000003647944I2D: score=2 STRING: ENSP00000364794
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    GOLGA3Q083783, ENSP000002047264I2D: score=1 STRING: ENSP00000204726
    YME1L1Q96TA23, ENSP000003184804I2D: score=1 STRING: ENSP00000318480
    LARSQ9P2J53, ENSP000003779544I2D: score=2 STRING: ENSP00000377954
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006520cellular amino acid metabolic process ----
    GO:0006563L-serine metabolic process IDA11054547
    GO:0007420brain development IEA--
    GO:0007568aging IEA--
    GO:0009069serine family amino acid metabolic process ISS--

    Find genes that share ontologies with SRR           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    6 ApexBio Compounds for SRR     About this table
    CompoundAction CAS #
    AEBSF.HClIrreversible serine protease inhibitor[30827-99-7]
    AprotininAprotinin, a naturally occurring serine protease inhibitor[9087-70-1]
    BCX 1470serine protease inhibitor[217099-43-9]
    Leupeptin, Microbialinhibitor of serine and cysteine proteases[103476-89-7]
    Nafamostat Mesylate(FUT-175)inhibitor of serine protease[82956-11-4]
    PMSFirreversible inhibitor of serine proteinases[329-98-6]

    Browse Tocris compounds for SRR

    3 HMDB Compounds for SRR    About this table
    CompoundSynonyms CAS #PubMed Ids
    D-Serine(2R)-2-amino-3-hydroxypropanoate (see all 8)312-84-5--
    L-Serine(-)-Serine (see all 26)56-45-1--
    Pyridoxal 5'-phosphateApolon B6 (see all 27)54-47-7--

    2 DrugBank Compounds for SRR    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pyridoxal PhosphateCodecarboxylase (see all 9)54-47-7targetcofactor15306409 16289454 16185077 12596860 12560076
    L-Serine(-)-Serine (see all 11)56-45-1target--17499824 17663143

    8 Novoseek inferred chemical compound relationships for SRR gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nmda 79 23 11309496 (2), 12176074 (2), 17067558 (2), 12393813 (1) (see all 13)
    serine 78.6 235 17880399 (8), 20091774 (7), 15193426 (6), 15536068 (6) (see all 44)
    glutamate 67 5 17006901 (1), 18812225 (1), 20106978 (1), 12176074 (1) (see all 5)
    pyridoxal 5-phosphate 58.8 1 19791805 (1)
    pyruvate 36 4 20091774 (2), 11309496 (1), 15681805 (1)
    valine 25.8 1 12393813 (1)
    nitric oxide 12.3 7 16182447 (3), 16298487 (1), 20021361 (1)
    calcium 0 3 12021263 (2), 17172010 (1)



    Find genes that share compounds with SRR           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SRR gene: 
    NM_021947.1  

    Unigene Cluster for SRR:

    Serine racemase
    Hs.461954  [show with all ESTs]
    Unigene Representative Sequence: AK023169
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000572709 ENST00000344595(uc002fue.1 uc002fui.1) ENST00000575840
    ENST00000576620 ENST00000576848 ENST00000574987 ENST00000570662 ENST00000574229(uc002fuh.1)

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate SRR:
    hsa-miR-3140-3p
    SwitchGear 3'UTR luciferase reporter plasmidSRR 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: SRR (NM_004451)
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      QuantiFast Probe-based Assays in human, mouse, rat SRR

    Additional mRNA sequence: 

    AF169974.1 AK023169.1 AK223120.1 AL834378.1 AY034081.1 AY743705.1 AY743706.1 AY743707.1 
    AY743708.1 BC010266.1 BC057234.1 BC074728.2 CR457300.1 

    12 DOTS entries:

    DT.99974731  DT.99953799  DT.454995  DT.95352513  DT.121010804  DT.121010872  DT.121010997  DT.91711597 
    DT.446103  DT.121010845  DT.100044581  DT.121010822 

    Selected AceView cDNA sequences (see all 88):

    CB129474 AK023169 AI952697 BU625449 NM_021947 CR457300 BM713885 AY034081 
    BU738738 Z39268 AV649514 AU131397 AF169974 H88365 AI291087 BI259607 
    AL834378 AI500493 BU739679 Z43188 BX327441 BG152669 BC074728 AA454853 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SRR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAGAGCCTG
    SRR Expression
    About this image


    SRR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Thalamus
     
     Bone (Muscoskeletal System)
             Membranous Facial Bones
     
     Neural Tube (Nervous System)
             Diencephalon
    SRR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SRR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.461954

    UniProtKB/Swiss-Prot: SRR_HUMAN, Q9GZT4
    Tissue specificity: Brain: expressed at high levels in hippocampus and corpus callosum, intermediate levels in
    substantia nigra and caudate, and low levels in amygdala, thalamus, and subthalamic nuclei. Expressed in heart,
    skeletal muscle, kidney and liver

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SRR: 
              Amino Acid Metabolism II in human mouse rat
              GABA & Glutamate in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat SRR
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SRR gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srr1 , 5 serine racemase1, 5 88.3(n)1
    89.97(a)1
      11 (45.76 cM)5
    273641  NM_013761.41  NP_038789.11 
     749065095 
    chicken
    (Gallus gallus)
    Aves SRR1 serine racemase 67.39(n)
    71.03(a)
      771635  XM_001234890.3  XP_001234891.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia srr1 serine racemase 66.56(n)
    66.87(a)
      100144980  NM_001126546.1  NP_001120018.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch73-263o4.31 si:ch73-263o4.3 47.37(n)
    36.09(a)
      100331432  XM_002661464.3  XP_002661510.3 
    worm
    (Caenorhabditis elegans)
    Secernentea T01H8.23 threonine dehydratase 38(a)   I(8579684-8581807)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SRY1(YKL218C)4
    SRY11
    3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate more4
    SRY11
    50.95(n)1
    42.09(a)1
      11(18339-17359)4
    8536621, 4  NP_012704.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SR1 SR 54.88(n)
    51.59(a)
      826769  NM_117233.2  NP_192901.2 
    rice
    (Oryza sativa)
    Liliopsida Os04g05559001 Os04g0555900 51.75(n)
    48.25(a)
      4336624  NM_001060056.1  NP_001053521.1 


    ENSEMBL Gene Tree for SRR (if available)
    TreeFam Gene Tree for SRR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SRR gene
    1 SIMAP similar gene for SRR using alignment to 7 protein entries:     SRR_HUMAN (see all proteins):
    DKFZp762A2415

    Find genes that share paralogs with SRR           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SRR (see all 318)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1922926231,2
    --2209289(+) CGCCCA/GGCCTT 1 -- int10--------
    rs1843094491,2
    --2209574(+) CACTGC/TACTCC 1 -- int10--------
    rs1905335621,2
    --2209849(+) CTACTA/GAAAAT 1 -- int10--------
    rs46067471,2
    C,F,A--2209871(+) CCGGGT/CGTGGT 1 -- int14Minor allele frequency- C:0.25NA 8
    rs45489131,2
    C,F,A--2209888(+) TGCCTA/GTAATC 1 -- int14Minor allele frequency- G:0.25NA 8
    rs1932324641,2
    --2209959(+) TGAGCC/TGAGAT 1 -- int10--------
    rs1844362601,2
    --2210040(+) TCCACA/CCATGG 1 -- int10--------
    rs562289041,2
    C--2210084(+) AGCTCA/GTACAG 1 -- int10--------
    rs1893242421,2
    --2210176(+) CTCGCA/GGACTG 1 -- int10--------
    rs557473171,2
    C--2210190(+) GGTAAC/TGAGAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for SRR (2206677 - 2228554 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SRR:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1317366CNV Insertion17803354
    nsv833336CNV Loss17160897
    nsv907529CNV Gain21882294
    nsv469765CNV Complex16826518

    Human Gene Mutation Database (HGMD): SRR
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SRR
    DNA2.0 Custom Variant and Variant Library Synthesis for SRR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606477    OMIM disorders: --

    4 diseases for SRR:    
    About MalaCards
    serine deficiency    miller-dieker syndrome    rabies    schizophrenia

    2 diseases from the University of Copenhagen DISEASES database for SRR:
    Schizophrenia     Serine deficiency

    Find genes that share disorders with SRR           About GenesLikeMe

    5 Novoseek inferred disease relationships for SRR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 49.9 17 17880399 (4), 17067558 (4), 15953485 (3), 17413455 (1) (see all 8)
    neurodegenerative diseases 28.9 1 12176074 (1)
    glioblastoma 22.8 4 16182447 (2), 16298487 (1)
    alzheimers disease 14.4 1 18812225 (1)
    stroke 0 2 18812225 (1), 12176074 (1)

    Genetic Association Database (GAD): SRR
    Human Genome Epidemiology (HuGE) Navigator: SRR (12 documents)

    Export disorders for SRR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SRR gene, integrated from 10 sources (see all 77):
    (articles sorted by number of sources associating them with SRR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization and localization of a human serine racemase. (PubMed id 15193426)1, 2, 3, 9 Xia M.... Connolly T.M. (Brain Res. Mol. Brain Res. 2004)
    2. A genetic variant of the serine racemase gene is associated with schizophrenia. (PubMed id 17067558)1, 3, 4, 9 Morita Y....Kuroda S. (Biol. Psychiatry 2007)
    3. Identification of multiple serine racemase (SRR) mRNA isoforms and genetic analyses of SRR and DAO in schizophrenia and D-serine levels. (PubMed id 15953485)1, 3, 9 Yamada K....Yoshikawa T. (Biol. Psychiatry 2005)
    4. Human serine racemase: molecular cloning, genomic organization and functional expression. (PubMed id 11054547)1, 2, 9 De Miranda J.... Wolosker H. (Gene 2000)
    5. The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor binding. (PubMed id 20106978)1, 2, 9 Smith M.A.... Barker J. (J. Biol. Chem. 2010)
    6. A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese. (PubMed id 20174558)1, 4, 9 Tsai F.J....Wu J.Y. (PLoS Genet. 2010)
    7. No association between the serine racemase gene (SRR) and bipolar disorder in a German case-control sample. (PubMed id 17413456)1, 4, 9 Schirmbeck F....Rietschel M. (Psychiatr. Genet. 2007)
    8. Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. (PubMed id 19584346)1, 4 Vasan R.S....Blankenberg S. (JAMA 2009)
    9. Association analysis of glycine- and serine-related genes in a Japanese population of patients with schizophrenia. (PubMed id 19223009)1, 4 Ohnuma T....Arai H. (amp 2009)
    10. Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. (PubMed id 18583979)1, 4 Allen N.C....Bertram L. (Nat. Genet. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 63826 HGNC: 14398 AceView: SRR Ensembl:ENSG00000167720 euGenes: HUgn63826
    ECgene: SRR Kegg: 63826 H-InvDB: SRR

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SRR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SRR gene:
    Search GeneIP for patents involving SRR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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