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Aliases for SRPX2 Gene

Aliases for SRPX2 Gene

  • Sushi-Repeat Containing Protein, X-Linked 2 2 3
  • SRPUL 3 4 6
  • Sushi-Repeat Protein Upregulated In Leukemia 3 4
  • Sushi-Repeat-Containing Protein, X-Linked 2 2 3
  • RESDX 3 6
  • Sushi-Repeat Protein Up-Regulated In Leukemia 3
  • Sushi Repeat-Containing Protein SRPX2 3
  • CBPS 3
  • PMGX 3
  • BPP 3

External Ids for SRPX2 Gene

Summaries for SRPX2 Gene

Entrez Gene Summary for SRPX2 Gene

  • This gene encodes a secreted protein that contains three sushi repeat motifs. The encoded protein may play a role in the development of speech and language centers in the brain. This protein may also be involved in angiogenesis. Mutations in this gene are the cause of bilateral perisylvian polymicrogyria, rolandic epilepsy, speech dyspraxia and mental retardation. [provided by RefSeq, May 2010]

GeneCards Summary for SRPX2 Gene

SRPX2 (Sushi-Repeat Containing Protein, X-Linked 2) is a Protein Coding gene. Diseases associated with SRPX2 include pseudobulbar palsy and rolandic epilepsy, mental retardation, and speech dyspraxia. GO annotations related to this gene include receptor binding. An important paralog of this gene is CCDC80.

UniProtKB/Swiss-Prot for SRPX2 Gene

  • Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. May have a role in the perisylvian region, critical for language and cognitive development.

Gene Wiki entry for SRPX2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRPX2 Gene

Genomics for SRPX2 Gene

Genomic Location for SRPX2 Gene

Start:
100,644,166 bp from pter
End:
100,671,299 bp from pter
Size:
27,134 bases
Orientation:
Plus strand

Genomic View for SRPX2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SRPX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRPX2 Gene

Regulatory Elements for SRPX2 Gene

Proteins for SRPX2 Gene

  • Protein details for SRPX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60687-SRPX2_HUMAN
    Recommended name:
    Sushi repeat-containing protein SRPX2
    Protein Accession:
    O60687
    Secondary Accessions:
    • B3KQT3
    • Q8WW85

    Protein attributes for SRPX2 Gene

    Size:
    465 amino acids
    Molecular mass:
    52972 Da
    Quaternary structure:
    • Forms homooligomers (By similarity). Interacts with PLAUR (via the UPAR/Ly6 domains), ADAMTS4 and CTSB. Interacts with HGF; the interaction increases the mitogenic activity of HGF.

neXtProt entry for SRPX2 Gene

Proteomics data for SRPX2 Gene at MOPED

Post-translational modifications for SRPX2 Gene

Other Protein References for SRPX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SRPX2 Gene

Domains for SRPX2 Gene

Protein Domains for SRPX2 Gene

UniProtKB/Swiss-Prot:

SRPX2_HUMAN
Domain:
  • Contains 1 HYR domain.:
    • O60687
  • Contains 3 Sushi (CCP/SCR) domains.:
    • O60687
genes like me logo Genes that share domains with SRPX2: view

No data available for Gene Families for SRPX2 Gene

Function for SRPX2 Gene

Molecular function for SRPX2 Gene

UniProtKB/Swiss-Prot Function: Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. May have a role in the perisylvian region, critical for language and cognitive development.

Gene Ontology (GO) - Molecular Function for SRPX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 18718938
GO:0005515 protein binding IPI 18718938
GO:0036458 hepatocyte growth factor binding IDA 22242148
GO:0042802 identical protein binding IDA 24179158
genes like me logo Genes that share ontologies with SRPX2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SRPX2 Gene

Localization for SRPX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRPX2 Gene

Secreted. Cytoplasm. Cell surface. Cell junction, synapse.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRPX2 Gene COMPARTMENTS Subcellular localization image for SRPX2 gene
Compartment Confidence
extracellular 5
cytoskeleton 4
endoplasmic reticulum 1
lysosome 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SRPX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22242148
GO:0005737 cytoplasm IDA 19065654
GO:0009986 cell surface ISS --
GO:0030054 cell junction IEA --
GO:0060076 excitatory synapse ISS --
genes like me logo Genes that share ontologies with SRPX2: view

Pathways for SRPX2 Gene

SuperPathways for SRPX2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SRPX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0016337 single organismal cell-cell adhesion IDA 19065654
GO:0042325 regulation of phosphorylation IDA 19065654
GO:0048870 cell motility IDA 19065654
GO:0051965 positive regulation of synapse assembly IDA 24179158
genes like me logo Genes that share ontologies with SRPX2: view

No data available for Pathways by source for SRPX2 Gene

Transcripts for SRPX2 Gene

mRNA/cDNA for SRPX2 Gene

Unigene Clusters for SRPX2 Gene

Sushi-repeat containing protein, X-linked 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SRPX2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - -
SP5: -

Relevant External Links for SRPX2 Gene

GeneLoc Exon Structure for
SRPX2
ECgene alternative splicing isoforms for
SRPX2

Expression for SRPX2 Gene

mRNA expression in normal human tissues for SRPX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SRPX2 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (4.7) and Adipose - Subcutaneous (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SRPX2 Gene

SOURCE GeneReport for Unigene cluster for SRPX2 Gene Hs.306339

mRNA Expression by UniProt/SwissProt for SRPX2 Gene

O60687-SRPX2_HUMAN
Tissue specificity: Expressed in neurons of the rolandic area of the brain (at protein level). Highly expressed in the brain, placenta, lung, trachea, uterus, adrenal gland, heart, ovary and placenta. Weakly expressed in the peripheral blood, brain and bone marrow. Expressed in numerous cancer cell lines and in gastrointestinal cancer cells. Higher levels found in colorectal cancers than in normal colonic mucosa.
genes like me logo Genes that share expressions with SRPX2: view

Orthologs for SRPX2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SRPX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRPX2 36
  • 99.86 (n)
  • 99.78 (a)
SRPX2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SRPX2 36
  • 91.83 (n)
  • 95.05 (a)
SRPX2 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRPX2 36
  • 93.26 (n)
  • 96.99 (a)
SRPX2 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srpx2 36
  • 89.61 (n)
  • 93.76 (a)
Srpx2 16
Srpx2 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SRPX2 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRPX2 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Srpx2 36
  • 89.3 (n)
  • 94.36 (a)
chicken
(Gallus gallus)
Aves SRPX2 36
  • 72.96 (n)
  • 74.4 (a)
SRPX2 37
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia srpx2 36
  • 64.17 (n)
  • 68.06 (a)
zebrafish
(Danio rerio)
Actinopterygii srpx2 36
  • 58.44 (n)
  • 53.74 (a)
srpx2 37
  • 53 (a)
OneToOne
Species with no ortholog for SRPX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SRPX2 Gene

ENSEMBL:
Gene Tree for SRPX2 (if available)
TreeFam:
Gene Tree for SRPX2 (if available)

Paralogs for SRPX2 Gene

Paralogs for SRPX2 Gene

Selected SIMAP similar genes for SRPX2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SRPX2: view

Variants for SRPX2 Gene

Sequence variations from dbSNP and Humsavar for SRPX2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs877358 -- 100,648,034(+) TGAGG(A/G)CTCTT intron-variant
rs1204405 -- 100,642,250(+) CTCTC(A/T)CACAC upstream-variant-2KB
rs1204406 -- 100,649,690(+) TGCTC(C/T)GCCCT intron-variant
rs1204407 -- 100,649,875(+) TGTGC(A/G)TGCAT intron-variant
rs1204408 -- 100,650,248(+) ACCCC(C/T)AGCAA intron-variant

Relevant External Links for SRPX2 Gene

HapMap Linkage Disequilibrium report
SRPX2
Human Gene Mutation Database (HGMD)
SRPX2
Locus Specific Mutation Databases (LSDB)
SRPX2

No data available for Structural Variations from Database of Genomic Variants (DGV) for SRPX2 Gene

Disorders for SRPX2 Gene

(1) OMIM Diseases for SRPX2 Gene (300642)

UniProtKB/Swiss-Prot

SRPX2_HUMAN
  • Rolandic epilepsy with speech dyspraxia and mental retardation X-linked (RESDX) [MIM:300643]: A condition characterized by the association of rolandic seizures with oral and speech dyspraxia, and mental retardation. Rolandic seizures occur during a period of significant brain maturation. During this time, dysfunction of neural network activities such as focal discharges may be associated with specific developmental disabilities resulting in specific cognitive impairments of language, visuo-spatial abilities or attention. {ECO:0000269 PubMed:16497722}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SRPX2

Genetic Association Database (GAD)
SRPX2
genes like me logo Genes that share disorders with SRPX2: view

Publications for SRPX2 Gene

  1. Two candidate downstream target genes for E2A-HLF. (PMID: 9864177) Kurosawa H. … Look A.T. (Blood 1999) 2 3 4
  2. SRPX2 mutations in disorders of language cortex and cognition. (PMID: 16497722) Roll P. … Szepetowski P. (Hum. Mol. Genet. 2006) 3 4 23
  3. SRPX2 is a novel chondroitin sulfate proteoglycan that is overexpressed in gastrointestinal cancer. (PMID: 22242148) Tanaka K. … Nishio K. (PLoS ONE 2012) 3 4
  4. Epileptic and developmental disorders of the speech cortex: ligand/receptor interaction of wild-type and mutant SRPX2 with the plasminogen activator receptor uPAR. (PMID: 18718938) Royer-Zemmour B. … Szepetowski P. (Hum. Mol. Genet. 2008) 3 4
  5. SRPX2 is overexpressed in gastric cancer and promotes cellular migration and adhesion. (PMID: 19065654) Tanaka K. … Nishio K. (Int. J. Cancer 2009) 3 4

Products for SRPX2 Gene

Sources for SRPX2 Gene

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