Aliases for SRPX2 Gene
External Ids for SRPX2 Gene
Previous GeneCards Identifiers for SRPX2 Gene
This gene encodes a secreted protein that contains three sushi repeat motifs. The encoded protein may play a role in the development of speech and language centers in the brain. This protein may also be involved in angiogenesis. Mutations in this gene are the cause of bilateral perisylvian polymicrogyria, rolandic epilepsy, speech dyspraxia and mental retardation. [provided by RefSeq, May 2010]
GeneCards Summary for SRPX2 Gene
SRPX2 (Sushi Repeat Containing Protein, X-Linked 2) is a Protein Coding gene. Diseases associated with SRPX2 include rolandic epilepsy, mental retardation, and speech dyspraxia and rolandic epilepsy-speech dyspraxia syndrome. GO annotations related to this gene include identical protein binding and hepatocyte growth factor binding. An important paralog of this gene is CCDC80.
UniProtKB/Swiss-Prot for SRPX2 Gene
Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. May have a role in the perisylvian region, critical for language and cognitive development.