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Aliases for SRPX Gene

Aliases for SRPX Gene

  • Sushi-Repeat Containing Protein, X-Linked 2 3
  • ETX1 3 4 6
  • Sushi-Repeat-Containing Protein, X Chromosome 2 3
  • Sushi-Repeat-Containing Protein, X-Linked 2 3
  • Epididymis Secretory Sperm Binding Protein Li 83p 3
  • Sushi Repeat-Containing Protein SRPX 3
  • HEL-S-83p 3
  • SRPX1 3
  • DRS 3

External Ids for SRPX Gene

Previous GeneCards Identifiers for SRPX Gene

  • GC0XM036113
  • GC0XM036296
  • GC0XM036853
  • GC0XM037039
  • GC0XM037764
  • GC0XM037893
  • GC0XM038009
  • GC0XM035753

Summaries for SRPX Gene

GeneCards Summary for SRPX Gene

SRPX (Sushi-Repeat Containing Protein, X-Linked) is a Protein Coding gene. Diseases associated with SRPX include pulmonary neuroendocrine tumor and neuroendocrine tumor. An important paralog of this gene is CCDC80.

UniProtKB/Swiss-Prot for SRPX Gene

  • May be involved in phagocytosis during disk shedding, cell adhesion to cells other than the pigment epithelium or signal transduction

Gene Wiki entry for SRPX Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRPX Gene

Genomics for SRPX Gene

Regulatory Elements for SRPX Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SRPX Gene

Start:
38,149,335 bp from pter
End:
38,220,924 bp from pter
Size:
71,590 bases
Orientation:
Minus strand

Genomic View for SRPX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SRPX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRPX Gene

Proteins for SRPX Gene

  • Protein details for SRPX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78539-SRPX_HUMAN
    Recommended name:
    Sushi repeat-containing protein SRPX
    Protein Accession:
    P78539
    Secondary Accessions:
    • A8K065
    • B3KWP8
    • B4DDB8
    • B4DQH5
    • F5H4D7
    • G3V1L0
    • Q4VX66
    • Q99652
    • Q99913

    Protein attributes for SRPX Gene

    Size:
    464 amino acids
    Molecular mass:
    51572 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SRPX Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRPX Gene

Proteomics data for SRPX Gene at MOPED

Post-translational modifications for SRPX Gene

  • Glycosylation at Thr240 and Thr328
  • Modification sites at PhosphoSitePlus

Other Protein References for SRPX Gene

No data available for DME Specific Peptides for SRPX Gene

Domains for SRPX Gene

Protein Domains for SRPX Gene

Suggested Antigen Peptide Sequences for SRPX Gene

Graphical View of Domain Structure for InterPro Entry

P78539

UniProtKB/Swiss-Prot:

SRPX_HUMAN :
  • P78539
Domain:
  • Contains 1 HYR domain.
  • Contains 3 Sushi (CCP/SCR) domains.
genes like me logo Genes that share domains with SRPX: view

No data available for Gene Families for SRPX Gene

Function for SRPX Gene

Molecular function for SRPX Gene

GENATLAS Biochemistry: short consensus repeat protein 1,X chromosome,abundantly expressed in retina,deleted in patients with retinitis pigmentosa (RP3)
UniProtKB/Swiss-Prot Function: May be involved in phagocytosis during disk shedding, cell adhesion to cells other than the pigment epithelium or signal transduction

Gene Ontology (GO) - Molecular Function for SRPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SRPX: view

Phenotypes for SRPX Gene

genes like me logo Genes that share phenotypes with SRPX: view

Animal Models for SRPX Gene

MGI Knock Outs for SRPX:

Animal Model Products

CRISPR Products

miRNA for SRPX Gene

miRTarBase miRNAs that target SRPX

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SRPX

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SRPX Gene

Localization for SRPX Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRPX Gene

Cell surface. Note=Possibly surface of photoreceptor cell.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRPX Gene COMPARTMENTS Subcellular localization image for SRPX gene
Compartment Confidence
extracellular 3
plasma membrane 3
endoplasmic reticulum 2
vacuole 2
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SRPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005776 autophagic vacuole IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0009986 cell surface IEA --
GO:0016020 membrane TAS 8634708
genes like me logo Genes that share ontologies with SRPX: view

Pathways for SRPX Gene

SuperPathways for SRPX Gene

No Data Available

Gene Ontology (GO) - Biological Process for SRPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001845 phagolysosome assembly IEA --
GO:0006914 autophagy IEA --
GO:0007155 cell adhesion IEA --
GO:0034976 response to endoplasmic reticulum stress IEA --
GO:0060244 negative regulation of cell proliferation involved in contact inhibition IEA --
genes like me logo Genes that share ontologies with SRPX: view

No data available for Pathways by source for SRPX Gene

Transcripts for SRPX Gene

Unigene Clusters for SRPX Gene

Sushi-repeat containing protein, X-linked:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SRPX

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRPX Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1:
SP2: -
SP3: -

Relevant External Links for SRPX Gene

GeneLoc Exon Structure for
SRPX
ECgene alternative splicing isoforms for
SRPX

Expression for SRPX Gene

mRNA expression in normal human tissues for SRPX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SRPX Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (5.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SRPX Gene

SOURCE GeneReport for Unigene cluster for SRPX Gene Hs.15154

mRNA Expression by UniProt/SwissProt for SRPX Gene

P78539-SRPX_HUMAN
Tissue specificity: Retina and heart; less in placenta, pancreas, lung, liver, skeletal muscle, kidney and brain
genes like me logo Genes that share expressions with SRPX: view

In Situ Assay Products

Orthologs for SRPX Gene

This gene was present in the common ancestor of chordates.

Orthologs for SRPX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRPX 35
  • 99.05 (n)
  • 98.82 (a)
SRPX 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SRPX 35
  • 89.93 (n)
  • 91.3 (a)
SRPX 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPGR 36
  • 97 (a)
OneToOne
SRPX 35
  • 91.36 (n)
  • 95.46 (a)
mouse
(Mus musculus)
Mammalia Srpx 35
  • 88 (n)
  • 92.67 (a)
Srpx 16
Srpx 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SRPX 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRPX 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Srpx 35
  • 87.5 (n)
  • 93.1 (a)
chicken
(Gallus gallus)
Aves SRPX 35
  • 75.31 (n)
  • 80.5 (a)
lizard
(Anolis carolinensis)
Reptilia SRPX 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494595 35
  • 68.65 (n)
  • 72.71 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.14621 35
srpx 35
  • 63.34 (n)
  • 62.41 (a)
srpx 36
  • 60 (a)
OneToOne
Species with no ortholog for SRPX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SRPX Gene

ENSEMBL:
Gene Tree for SRPX (if available)
TreeFam:
Gene Tree for SRPX (if available)

Paralogs for SRPX Gene

Paralogs for SRPX Gene

Selected SIMAP similar genes for SRPX Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SRPX: view

Variants for SRPX Gene

Sequence variations from dbSNP and Humsavar for SRPX Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs9934 -- 38,149,474(-) GGCTG(C/G)TTGAT utr-variant-3-prime
rs13263 -- 38,154,576(-) AGCAC(A/T)GTGTG reference, missense, intron-variant
rs743151 -- 38,169,273(-) AGAAT(A/G)AATGT intron-variant
rs762067 -- 38,187,404(+) CCACC(A/T)GGAAA intron-variant
rs880018 -- 38,185,498(+) AAACA(C/T)GATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRPX Gene

Variant ID Type Subtype PubMed ID
nsv6866 CNV Loss 18451855
nsv525751 CNV Gain 19592680

Relevant External Links for SRPX Gene

HapMap Linkage Disequilibrium report
SRPX
Human Gene Mutation Database (HGMD)
SRPX
Locus Specific Mutation Databases (LSDB)
SRPX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRPX Gene

Disorders for SRPX Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for SRPX Gene including...

Search for SRPX Gene in MalaCards »

(1) University of Copenhagen DISEASES for SRPX Gene

Relevant External Links for SRPX

Genetic Association Database (GAD)
SRPX
genes like me logo Genes that share disorders with SRPX: view

No data available for UniProtKB/Swiss-Prot for SRPX Gene

Publications for SRPX Gene

  1. A gene (SRPX) encoding a sushi-repeat-containing protein is deleted in patients with X-linked retinitis pigmentosa. (PMID: 8634708) Meindl A. … Meitinger T. (Hum. Mol. Genet. 1995) 2 3 4 23
  2. Identification of a novel gene, ETX1 from Xp21.1, a candidate gene for X-linked retinitis pigmentosa (RP3). (PMID: 8634709) Dry K.L. … Wright A.F. (Hum. Mol. Genet. 1995) 2 3 4
  3. Down-regulation of drs mRNA in colorectal neoplasms. (PMID: 12716466) Mukaisho K. … Hattori T. (Jpn. J. Cancer Res. 2002) 3 23
  4. Cloning of a new human gene with short consensus repeats using the EST database. (PMID: 9162095) Nangaku M. … Couser W.G. (Immunogenetics 1997) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SRPX Gene

Sources for SRPX Gene

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