SRPX Gene
protein-coding GIFtS : 54 GCID: GC0X M038009
sushi-repeat containing protein, X-linked sushi-repeat-containing protein, X chromosome, sushi-repeat-containing...
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Aliasesfor SRPX gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Sushi-Repeat Containing Protein, X-Linked 1 2 DRS2 ETX11 2 3 5 SRPX12 Sushi-Repeat-Containing Protein, X Chromosome1 2 Sushi Repeat-Containing Protein SRPX2 Sushi-Repeat-Containing Protein, X-Linked1 2
Export aliases for SRPX gene to outside databases Previous GC identifers: GC0XM036113 GC0XM036296 GC0XM036853 GC0XM037039 GC0XM037764 GC0XM037893 GC0XM035753
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Summariesfor SRPX gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: SRPX_HUMAN, P78539 Function : May be involved in phagocytosis during disk shedding, cell adhesion to cells other than the pigmentepithelium or signal transduction Gene Wiki entry for SRPX
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Genomic Viewsfor SRPX gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000023.10 NC_018934.1 NT_079573.4 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SRPX gene promoter:COUP-TF1 COUP STAT5A LUN-1 HNF-4alpha2 HNF-4alpha1 COUP-TF IRF-7A Sox9 MRF-2 Other transcription factors Search SABiosciences Chromatin IP Primers for SRPX Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: Xp21.1 Ensembl cytogenetic band: Xp11.4 HGNC cytogenetic band: Xp21.1 SRPX Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome X GeneLoc Exon Structure
GeneLoc location for GC0XM038009: view genomic region
(about GC identifiers )
Start: 38,008,588 bp from pter End:
38,080,696 bp from pter
Size: 72,109 bases Orientation:
minus strand
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Proteinsfor SRPX gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: SRPX_HUMAN, P78539 See
protein sequence )Recommended Name: Size : 464 amino acids; 51572 DaSubcellular location : Cell surface (Probable). Note=Possibly surface of photoreceptor cellSecondary accessions : A8K065 B4DDB8 B4DQH5 F5H4D7 Q4VX66 Q99652 Q99913Alternative splicing : 4 isoforms : P78539-1 P78539-2 P78539-3 P78539-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SRPX: NX_P78539 SRPX Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (4 alternative transcripts): NP_001164221.1 NP_001164222.1 NP_001164223.1 NP_006298.1 ENSEMBL proteins: ENSP00000367794 ENSP00000339211 ENSP00000440758 ENSP00000411165 ENSP00000445034 Human Recombinant Protein Products for SRPX: Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view) : About this table
About GeneDecksing SRPX Antibody Products: Assay Products for SRPX:
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Protein
Domains /for SRPX gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P78539 ProtoNet protein and cluster: P78539
1 Blocks protein family : IPB000436 UniProtKB/Swiss-Prot: SRPX_HUMAN, P78539 Similarity : Contains 1 HYR domainSimilarity : Contains 3 Sushi (CCP/SCR) domains
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Functionfor SRPX gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: SRPX_HUMAN, P78539 Function : May be involved in phagocytosis during disk shedding, cell adhesion to cells other than the pigmentepithelium or signal transduction
Genatlas biochemistry entry for SRPX short consensus repeat protein 1,X chromosome,abundantly expressed in retina,deleted in patients with retinitis pigmentosa (RP3) Phenotypes: 3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Srpx) :About GeneDecksing Animal Models: Srpx tm1Hzi for SRPXClone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 6 )human mouse rat see all 4 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 4 ): SRPX (NM_006307 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SRPX Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SRPX
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRPX
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Pathways & Interactionsfor SRPX gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SRPX STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)5/9 Interacting proteins for SRPX (P78539 3 ENSP00000367794 4 via UniProtKB, MINT, STRING , and/or I2D (see all 9 )About this table Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6 ): About this table
About GeneDecksing
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Drugs & Compoundsfor SRPX gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for SRPX SRPX
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Transcriptsfor SRPX gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for SRPX gene (4 alternative transcripts): NM_001170750.1 NM_001170751.1 NM_001170752.1 NM_006307.4 Unigene Cluster for SRPX:
Sushi-repeat containing protein, X-linked Hs.15154 [show with all ESTs ] Unigene Representative Sequence: BC020684 7 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000378533 (uc004ddy.2 ) ENST00000479015 ENST00000461865 ENST00000343800 ENST00000544439 (uc004ddz.2 ) ENST00000432886 (uc011mkh.2 ) ENST00000538295 (uc011mki.2 )Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 6 )human mouse rat see all 4 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 4 ): SRPX (NM_006307 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SRPX Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SRPX
Additional cDNA sequence: AK125542.1 AK289430.1 AK293127.1 AK298802.1 BC020684.1 U61374.1 U78093.1
5 DOTS entries : DT.454405 DT.100805480
DT.92424082 DT.100729132 DT.100793698 24/166 AceView cDNA sequences (see all 166 ):
AA298146 CR625902 CR606094 CR597663 N42227 AI373824 CR591734 BU188905 BI858830 CR592953 CR623087 BX115010 BX398316 BU186681 BX330640 CR609268 BP335709 BX335679 CR622289 BX356454 CR604296 CR613384 BP347389 BX357631 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for SRPX About this scheme ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b SP1 : SP2 : - SP3 : -
ECgene alternative splicing isoforms for SRPX
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Expression for SRPX gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section SRPX expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TTATTCAATGAbout this image SRPX expression in embryonic tissues and stem cells About this table
See SRPX Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SRPX SOURCE GeneReport for Unigene cluster: Hs.15154 UniProtKB/Swiss-Prot: SRPX_HUMAN, P78539 Tissue specificity : Retina and heart; less in placenta, pancreas, lung, liver, skeletal muscle, kidney and brainSABiosciences Custom PCR Arrays for SRPX Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRPX
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Orthologsfor SRPX gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for SRPX gene from 3/12 species (see all 12 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves SRPX1
sushi-repeat containing protein, X-linked
75.58(n) 80.93(a)
418579 XM_416781.3 XP_416781.3
lizard Reptilia SRPX6
--
75(a)
1 ↔ 1
3(132357474-132374813)
zebrafish Actinopterygii Dr.146212
Transcribed sequence with weak similarity to protein more
74.54(n)
CF997521.1
ENSEMBL Gene Tree for SRPX (if available)TreeFam Gene Tree for SRPX (if available)
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Paralogsfor SRPX gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for SRPX gene SRPX2 2 1 SIMAP similar gene for SRPX using alignment to 2 protein entries: SRPX_HUMAN (see all proteins ):SRPX2 About GeneDecksing
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Genomic Variantsfor SRPX gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr X pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for SRPX (38008588 - 38080696 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for SRPX: -- Human Gene Mutation Database (HGMD) : SRPX Locus Specific Mutation Databases (LSDB): SRPX SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor SRPX gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 300187
OMIM disorders : --9 : About MalaCards pulmonary neuroendocrine tumor neuroendocrine tumor retinitis pigmentosa lung adenocarcinoma retinitis prostate carcinoma adenocarcinoma prostatitis carcinoma 1 disease from the University of Copenhagen DISEASES database for SRPX :Retinitis pigmentosa Export disorders for SRPX gene to outside databases
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Publicationsfor SRPX gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for SRPX gene, integrated from 9 sources (see all 20 ):(articles sorted by number of sources associating them with SRPX) Utopia : connect your pdf to the dynamic
A gene (SRPX) encoding a sushi-repeat-containing protein is deleted in patients with X-linked retinitis pigmentosa. (PubMed id 8634708) 1 , 2 , 3, 9(1995) Identification of a novel gene, ETX1 from Xp21.1, a candidate gene for X-linked retintis pigmentosa (RP3). (PubMed id 8634709) 1 , 2 , 3(1995) The DNA sequence of the human X chromosome. (PubMed id 15772651) 1 , 2 (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 (2004) Cloning of a new human gene with short consensus repeats using the EST database. (PubMed id 9162095) 1 , 2 (1997) Down-regulation of drs mRNA in colorectal neoplasms. (PubMed id 12716466) 1 , 9(2002) Pelota interacts with HAX1, EIF3G and SRPX and the re sulting protein complexes are associated with the actin cytoskeleton. (PubMed id 20406461) 1 (2010) Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461) 1 (2010) ETX1 is over-expressed in the glaucomatous trabecular meshwork. (PubMed id 19862339) 1 (2009) Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732) 1 (2009)
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External Searches for SRPX gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing SRPX gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing SRPX gene
(According to HUGE )
About This Section --
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Specialized Databases showing SRPX gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for SRPX gene: SRPX GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor SRPX gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
OriGene Antibodies for SRPX OriGene shRNA RFP for SRPX OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for SRPX Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for SRPX OriGene 3'-UTR Clone for SRPX OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for SRPX OriGene Custom Protein Services for SRPX OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SRPX QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
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SRPX Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRPX
ThermoFisher Antibodies for SRPX
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SRPX
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Expression by the Database of Embryonic development, Stem cell research, and
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