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Aliases for SRPX Gene

Aliases for SRPX Gene

  • Sushi Repeat Containing Protein, X-Linked 2 3 5
  • Sushi-Repeat-Containing Protein, X Chromosome 2 3
  • ETX1 3 4
  • Epididymis Secretory Sperm Binding Protein Li 83p 3
  • Sushi-Repeat-Containing Protein, X-Linked 2
  • Sushi Repeat-Containing Protein SRPX 3
  • HEL-S-83p 3
  • SRPX1 3
  • DRS 3

External Ids for SRPX Gene

Previous GeneCards Identifiers for SRPX Gene

  • GC0XM036113
  • GC0XM036296
  • GC0XM036853
  • GC0XM037039
  • GC0XM037764
  • GC0XM037893
  • GC0XM038009
  • GC0XM035753

Summaries for SRPX Gene

GeneCards Summary for SRPX Gene

SRPX (Sushi Repeat Containing Protein, X-Linked) is a Protein Coding gene. Diseases associated with SRPX include Retinitis Pigmentosa. An important paralog of this gene is SRPX2.

UniProtKB/Swiss-Prot for SRPX Gene

  • May be involved in phagocytosis during disk shedding, cell adhesion to cells other than the pigment epithelium or signal transduction.

Gene Wiki entry for SRPX Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRPX Gene

Genomics for SRPX Gene

Regulatory Elements for SRPX Gene

Enhancers for SRPX Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF038268 1 FANTOM5 12.8 -47.3 -47263 0.3 RPGR ENSG00000226679 SRPX CYBB GC0XM038216 ENSG00000252050
GH0XF038271 0.9 FANTOM5 Ensembl 12.8 -50.6 -50611 0.5 TBL1XR1 BMI1 RELA ZNF316 CBX5 NFE2 CREM MAFK MTA2 ZBED1 RPGR SRPX ENSG00000226679 CYBB ENSG00000252050 GC0XM038216
GH0XF038278 0.5 ENCODE 12.2 -57.9 -57938 2.5 HDAC1 PKNOX1 TAL1 KLF17 ZMYM3 CEBPG THRB RARA ZNF664 FOSL1 SRPX ENSG00000226679 RPGR ENSG00000252050 GC0XM038216
GH0XF038213 1 Ensembl ENCODE 10.4 +5.8 5765 2.5 JUND SRPX GC0XM038061
GH0XF038219 1 FANTOM5 ENCODE 9.1 +0.3 282 1.7 CTCF KLF1 KLF17 ZIC2 RAD21 ZFHX2 GLIS2 POLR2A PATZ1 SCRT2 SRPX ENSG00000226679 GC0XM038061
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SRPX on UCSC Golden Path with GeneCards custom track

Promoters for SRPX Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000660342 524 2400 CTCF KLF1 KLF17 ZIC2 RAD21 ZFHX2 GLIS2 PATZ1 SCRT2 SMC3

Genomic Location for SRPX Gene

Chromosome:
X
Start:
38,149,335 bp from pter
End:
38,220,924 bp from pter
Size:
71,590 bases
Orientation:
Minus strand

Genomic View for SRPX Gene

Genes around SRPX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRPX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRPX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRPX Gene

Proteins for SRPX Gene

  • Protein details for SRPX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78539-SRPX_HUMAN
    Recommended name:
    Sushi repeat-containing protein SRPX
    Protein Accession:
    P78539
    Secondary Accessions:
    • A8K065
    • B3KWP8
    • B4DDB8
    • B4DQH5
    • F5H4D7
    • G3V1L0
    • Q4VX66
    • Q99652
    • Q99913

    Protein attributes for SRPX Gene

    Size:
    464 amino acids
    Molecular mass:
    51572 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SRPX Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRPX Gene

Post-translational modifications for SRPX Gene

  • Glycosylation at Thr 240 and Thr 328
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SRPX Gene

Domains & Families for SRPX Gene

Gene Families for SRPX Gene

Protein Domains for SRPX Gene

Suggested Antigen Peptide Sequences for SRPX Gene

Graphical View of Domain Structure for InterPro Entry

P78539

UniProtKB/Swiss-Prot:

SRPX_HUMAN :
  • Contains 1 HYR domain.
Domain:
  • Contains 1 HYR domain.
  • Contains 3 Sushi (CCP/SCR) domains.
genes like me logo Genes that share domains with SRPX: view

Function for SRPX Gene

Molecular function for SRPX Gene

GENATLAS Biochemistry:
short consensus repeat protein 1,X chromosome,abundantly expressed in retina,deleted in patients with retinitis pigmentosa (RP3)
UniProtKB/Swiss-Prot Function:
May be involved in phagocytosis during disk shedding, cell adhesion to cells other than the pigment epithelium or signal transduction.
genes like me logo Genes that share phenotypes with SRPX: view

Animal Models for SRPX Gene

MGI Knock Outs for SRPX:

Animal Model Products

miRNA for SRPX Gene

miRTarBase miRNAs that target SRPX

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SRPX Gene

Localization for SRPX Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRPX Gene

Cell surface. Note=Possibly surface of photoreceptor cell.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRPX Gene COMPARTMENTS Subcellular localization image for SRPX gene
Compartment Confidence
endoplasmic reticulum 3
extracellular 3
plasma membrane 3
vacuole 3
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SRPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005776 autophagosome IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0009986 cell surface IEA --
GO:0016020 membrane TAS 8634708
genes like me logo Genes that share ontologies with SRPX: view

Pathways & Interactions for SRPX Gene

SuperPathways for SRPX Gene

No Data Available

Gene Ontology (GO) - Biological Process for SRPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001845 phagolysosome assembly IEA --
GO:0006914 autophagy IEA --
GO:0007155 cell adhesion IEA --
GO:0034976 response to endoplasmic reticulum stress IEA --
GO:0060244 negative regulation of cell proliferation involved in contact inhibition IEA --
genes like me logo Genes that share ontologies with SRPX: view

No data available for Pathways by source and SIGNOR curated interactions for SRPX Gene

Transcripts for SRPX Gene

Unigene Clusters for SRPX Gene

Sushi-repeat containing protein, X-linked:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRPX Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1:
SP2: -
SP3: -

Relevant External Links for SRPX Gene

GeneLoc Exon Structure for
SRPX
ECgene alternative splicing isoforms for
SRPX

Expression for SRPX Gene

mRNA expression in normal human tissues for SRPX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SRPX Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x5.4).

Protein differential expression in normal tissues from HIPED for SRPX Gene

This gene is overexpressed in Gallbladder (23.2) and Pancreas (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SRPX Gene



Protein tissue co-expression partners for SRPX Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SRPX Gene:

SRPX

SOURCE GeneReport for Unigene cluster for SRPX Gene:

Hs.15154

mRNA Expression by UniProt/SwissProt for SRPX Gene:

P78539-SRPX_HUMAN
Tissue specificity: Retina and heart; less in placenta, pancreas, lung, liver, skeletal muscle, kidney and brain.
genes like me logo Genes that share expression patterns with SRPX: view

Primer Products

Orthologs for SRPX Gene

This gene was present in the common ancestor of chordates.

Orthologs for SRPX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRPX 34 35
  • 99.05 (n)
dog
(Canis familiaris)
Mammalia RPGR 35
  • 97 (a)
OneToOne
SRPX 34
  • 91.36 (n)
cow
(Bos Taurus)
Mammalia SRPX 34 35
  • 89.93 (n)
mouse
(Mus musculus)
Mammalia Srpx 34 16 35
  • 88 (n)
rat
(Rattus norvegicus)
Mammalia Srpx 34
  • 87.5 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SRPX 35
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SRPX 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves SRPX 34
  • 75.31 (n)
lizard
(Anolis carolinensis)
Reptilia SRPX 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494595 34
  • 68.65 (n)
zebrafish
(Danio rerio)
Actinopterygii srpx 34 35
  • 63.34 (n)
Dr.14621 34
Species where no ortholog for SRPX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SRPX Gene

ENSEMBL:
Gene Tree for SRPX (if available)
TreeFam:
Gene Tree for SRPX (if available)

Paralogs for SRPX Gene

Paralogs for SRPX Gene

(1) SIMAP similar genes for SRPX Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SRPX: view

Variants for SRPX Gene

Sequence variations from dbSNP and Humsavar for SRPX Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs10548058 -- 38,154,223(+) CACAC(-/AT)GAAGC intron-variant
rs10570334 -- 38,191,554(+) CACAC(-/AC)ACACA intron-variant
rs10597163 -- 38,221,819(+) GTTTT(-/GTTT)GTTTG upstream-variant-2KB
rs10612660 -- 38,149,140(+) AACTC(-/TT)TCATT downstream-variant-500B
rs10710053 -- 38,195,383(+) TGTGG(-/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRPX Gene

Variant ID Type Subtype PubMed ID
nsv525751 CNV gain 19592680
nsv6866 CNV deletion 18451855

Variation tolerance for SRPX Gene

Residual Variation Intolerance Score: 96.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.93; 83.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRPX Gene

Human Gene Mutation Database (HGMD)
SRPX
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRPX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRPX Gene

Disorders for SRPX Gene

MalaCards: The human disease database

(1) MalaCards diseases for SRPX Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association - COSMIC cancer census association via MalaCards
Search SRPX in MalaCards View complete list of genes associated with diseases

Relevant External Links for SRPX

Genetic Association Database (GAD)
SRPX
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRPX
genes like me logo Genes that share disorders with SRPX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SRPX Gene

Publications for SRPX Gene

  1. A gene (SRPX) encoding a sushi-repeat-containing protein is deleted in patients with X-linked retinitis pigmentosa. (PMID: 8634708) Meindl A. … Meitinger T. (Hum. Mol. Genet. 1995) 2 3 4 22 64
  2. Identification of a novel gene, ETX1 from Xp21.1, a candidate gene for X-linked retinitis pigmentosa (RP3). (PMID: 8634709) Dry K.L. … Wright A.F. (Hum. Mol. Genet. 1995) 2 3 4 64
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Down-regulation of drs mRNA in colorectal neoplasms. (PMID: 12716466) Mukaisho K. … Hattori T. (Jpn. J. Cancer Res. 2002) 3 22 64

Products for SRPX Gene

Sources for SRPX Gene

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