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Aliases for SRPRB Gene

Aliases for SRPRB Gene

  • Signal Recognition Particle Receptor, B Subunit 2 3
  • SR-Beta 3 4
  • Signal Recognition Particle Receptor, Beta Subunit 3
  • Signal Recognition Particle Receptor Subunit Beta 3
  • Protein APMCF1 4
  • APMCF1 3

External Ids for SRPRB Gene

Previous GeneCards Identifiers for SRPRB Gene

  • GC03P134845
  • GC03P135007
  • GC03P133503
  • GC03P130882
  • GC03P133505

Summaries for SRPRB Gene

Entrez Gene Summary for SRPRB Gene

  • The protein encoded by this gene has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and membrane proteins to the ER membrane. [provided by RefSeq, Jul 2008]

GeneCards Summary for SRPRB Gene

SRPRB (Signal Recognition Particle Receptor, B Subunit) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Unfolded Protein Response. GO annotations related to this gene include GTP binding and ferric iron binding.

UniProtKB/Swiss-Prot for SRPRB Gene

  • Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity).

Gene Wiki entry for SRPRB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRPRB Gene

Genomics for SRPRB Gene

Regulatory Elements for SRPRB Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SRPRB Gene

Start:
133,784,033 bp from pter
End:
133,825,772 bp from pter
Size:
41,740 bases
Orientation:
Plus strand

Genomic View for SRPRB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SRPRB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRPRB Gene

Proteins for SRPRB Gene

  • Protein details for SRPRB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5M8-SRPRB_HUMAN
    Recommended name:
    Signal recognition particle receptor subunit beta
    Protein Accession:
    Q9Y5M8
    Secondary Accessions:
    • Q6P595
    • Q8N2D8

    Protein attributes for SRPRB Gene

    Size:
    271 amino acids
    Molecular mass:
    29702 Da
    Quaternary structure:
    • Heterodimer with SRPR.

neXtProt entry for SRPRB Gene

Proteomics data for SRPRB Gene at MOPED

Post-translational modifications for SRPRB Gene

  • Ubiquitination at Lys191, Lys199, Lys230, and Lys265
  • Modification sites at PhosphoSitePlus

Other Protein References for SRPRB Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SRPRB Gene

Domains for SRPRB Gene

Protein Domains for SRPRB Gene

Suggested Antigen Peptide Sequences for SRPRB Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y5M8

UniProtKB/Swiss-Prot:

SRPRB_HUMAN :
  • Q9Y5M8
Family:
  • Belongs to the SRP receptor beta subunit family.
genes like me logo Genes that share domains with SRPRB: view

No data available for Gene Families for SRPRB Gene

Function for SRPRB Gene

Molecular function for SRPRB Gene

UniProtKB/Swiss-Prot Function: Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity).

Gene Ontology (GO) - Molecular Function for SRPRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with SRPRB: view

Phenotypes for SRPRB Gene

GenomeRNAi human phenotypes for SRPRB:
genes like me logo Genes that share phenotypes with SRPRB: view

Animal Model Products

CRISPR Products

miRNA for SRPRB Gene

miRTarBase miRNAs that target SRPRB

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SRPRB Gene

Localization for SRPRB Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRPRB Gene

Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRPRB Gene COMPARTMENTS Subcellular localization image for SRPRB gene
Compartment Confidence
cytoskeleton 5
endoplasmic reticulum 5
cytosol 2
extracellular 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SRPRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005737 cytoplasm IDA 19664239
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005881 cytoplasmic microtubule IDA 23264731
GO:0016020 membrane IDA 22375059
genes like me logo Genes that share ontologies with SRPRB: view

Pathways for SRPRB Gene

genes like me logo Genes that share pathways with SRPRB: view

Pathways by source for SRPRB Gene

Gene Ontology (GO) - Biological Process for SRPRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
GO:0006987 activation of signaling protein activity involved in unfolded protein response --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with SRPRB: view

Transcripts for SRPRB Gene

Unigene Clusters for SRPRB Gene

Signal recognition particle receptor, B subunit:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SRPRB

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRPRB Gene

No ASD Table

Relevant External Links for SRPRB Gene

GeneLoc Exon Structure for
SRPRB
ECgene alternative splicing isoforms for
SRPRB

Expression for SRPRB Gene

mRNA expression in normal human tissues for SRPRB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SRPRB Gene

This gene is overexpressed in Pancreas (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SRPRB Gene

SOURCE GeneReport for Unigene cluster for SRPRB Gene Hs.12152

genes like me logo Genes that share expressions with SRPRB: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SRPRB Gene

Orthologs for SRPRB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SRPRB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRPRB 35
  • 99.51 (n)
  • 99.26 (a)
SRPRB 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SRPRB 35
  • 90.41 (n)
  • 92.62 (a)
SRPRB 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRPRB 35
  • 88.68 (n)
  • 92.99 (a)
mouse
(Mus musculus)
Mammalia Srprb 35
  • 85.5 (n)
  • 91.08 (a)
Srprb 16
Srprb 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SRPRB 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRPRB 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Srprb 35
  • 86.37 (n)
  • 91.45 (a)
chicken
(Gallus gallus)
Aves GGA.31975 36
  • 74 (a)
OneToOne
LOC101750392 35
  • 73.83 (n)
  • 74.61 (a)
African clawed frog
(Xenopus laevis)
Amphibia apmcf1-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75930 35
srprb 35
  • 67.33 (n)
  • 66.14 (a)
zebrafish
(Danio rerio)
Actinopterygii srprb 35
  • 61.13 (n)
  • 59.51 (a)
srprb 36
  • 56 (a)
OneToOne
wufk57h10 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006688 35
  • 50.09 (n)
  • 44.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta SrpRbeta 35
  • 49.51 (n)
  • 40.78 (a)
SrpRbeta 36
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea R186.3 35
  • 45.66 (n)
  • 36.46 (a)
R186.3 36
  • 33 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SRP102 36
  • 25 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G05670 35
  • 47.34 (n)
  • 38.3 (a)
rice
(Oryza sativa)
Liliopsida Os08g0524000 35
  • 47.59 (n)
  • 37.11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7092 36
  • 41 (a)
OneToOne
Species with no ortholog for SRPRB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRPRB Gene

ENSEMBL:
Gene Tree for SRPRB (if available)
TreeFam:
Gene Tree for SRPRB (if available)

Paralogs for SRPRB Gene

No data available for Paralogs for SRPRB Gene

Variants for SRPRB Gene

Sequence variations from dbSNP and Humsavar for SRPRB Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1107413 - 133,805,873(-) TGCCA(C/G)CCGGC missense, reference
rs1464937 -- 133,817,811(+) AGTTG(C/G)GAGCA intron-variant
rs1534164 -- 133,816,238(+) CTCTT(C/T)CAGAT intron-variant
rs1534165 -- 133,818,073(+) TATCC(C/T)GCCCT intron-variant
rs1534166 -- 133,818,223(+) CTGTC(A/G)TAATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRPRB Gene

Variant ID Type Subtype PubMed ID
nsv877506 CNV Gain 21882294
nsv829729 CNV Loss 17160897
nsv4018 CNV Loss 18451855
esv1005045 CNV Deletion 20482838
nsv513074 CNV Loss 21212237
esv3892 CNV Deletion 18987735
esv8734 CNV Loss 19470904
esv2725943 CNV Deletion 23290073
esv2661320 CNV Deletion 23128226
esv989994 CNV Deletion 20482838
esv1301210 CNV Deletion 17803354

Relevant External Links for SRPRB Gene

HapMap Linkage Disequilibrium report
SRPRB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRPRB Gene

Disorders for SRPRB Gene

Relevant External Links for SRPRB

Genetic Association Database (GAD)
SRPRB
genes like me logo Genes that share disorders with SRPRB: view

No data available for UniProtKB/Swiss-Prot for SRPRB Gene

Publications for SRPRB Gene

  1. Genome-wide association study identifies two loci strongly affecting transferrin glycosylation. (PMID: 21665994) Kutalik Z. … Whitfield J.B. (Hum. Mol. Genet. 2011) 3 48
  2. Nucleotide-dependent binding of the GTPase domain of the signal recognition particle receptor beta-subunit to the alpha-subunit. (PMID: 10859309) Legate K.R. … Andrews D.W. (J. Biol. Chem. 2000) 2 23
  3. Isolation of a novel member of small G protein superfamily and its expression in colon cancer. (PMID: 12918107) Yan W. … Wang L. (World J. Gastroenterol. 2003) 3 23
  4. The beta subunit of the signal recognition particle receptor is a transmembrane GTPase that anchors the alpha subunit, a peripheral membrane GTPase, to the endoplasmic reticulum membrane. (PMID: 7844142) Miller J.D. … Walter P. (J. Cell Biol. 1995) 2 3
  5. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4

Products for SRPRB Gene

Sources for SRPRB Gene

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