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Aliases for SRPRB Gene

Aliases for SRPRB Gene

  • SRP Receptor Beta Subunit 2 3 5
  • Signal Recognition Particle Receptor, B Subunit 2 3
  • SR-Beta 3 4
  • Signal Recognition Particle Receptor, Beta Subunit 3
  • Signal Recognition Particle Receptor Subunit Beta 3
  • Protein APMCF1 4
  • APMCF1 3

External Ids for SRPRB Gene

Previous GeneCards Identifiers for SRPRB Gene

  • GC03P134845
  • GC03P135007
  • GC03P133503
  • GC03P130882
  • GC03P133505

Summaries for SRPRB Gene

Entrez Gene Summary for SRPRB Gene

  • The protein encoded by this gene has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and membrane proteins to the ER membrane. [provided by RefSeq, Jul 2008]

GeneCards Summary for SRPRB Gene

SRPRB (SRP Receptor Beta Subunit) is a Protein Coding gene. Among its related pathways are Gene Expression and Protein export. GO annotations related to this gene include GTP binding and GTPase activity.

UniProtKB/Swiss-Prot for SRPRB Gene

  • Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity).

Gene Wiki entry for SRPRB Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRPRB Gene

Genomics for SRPRB Gene

Regulatory Elements for SRPRB Gene

Enhancers for SRPRB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G133805 1 ENCODE 21.8 +22.1 22069 2.0 PKNOX1 ATF1 MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 SRPRB C3orf36 LOC105374116 PIR63043 GC03P133813
GH03G133763 0.8 ENCODE dbSUPER 21.4 -19.4 -19392 1.3 PAF1 ZNF146 POLR2A NFIA ZNF580 ZBTB33 RBFOX2 SRPRB TF C3orf36 LOC100421637
GH03G133568 1.7 FANTOM5 ENCODE dbSUPER 9.5 -211.7 -211676 9.0 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YBX1 FEZF1 YY1 SLC30A9 SRPRB TFP1 CDV3 RAB6B NPHP3 UBA5 GC03P133569
GH03G133912 0.4 FANTOM5 22.8 +128.4 128406 0.2 ZNF664 SRPRB RAB6B C3orf36
GH03G133754 0.5 dbSUPER 17.5 -28.5 -28513 1.2 POLR2A U2AF1 RBFOX2 NR2F2 TRIM28 SRPRB TF LOC100421637 PIR42738
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SRPRB on UCSC Golden Path with GeneCards custom track

Genomic Location for SRPRB Gene

Chromosome:
3
Start:
133,784,033 bp from pter
End:
133,825,772 bp from pter
Size:
41,740 bases
Orientation:
Plus strand

Genomic View for SRPRB Gene

Genes around SRPRB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRPRB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRPRB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRPRB Gene

Proteins for SRPRB Gene

  • Protein details for SRPRB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5M8-SRPRB_HUMAN
    Recommended name:
    Signal recognition particle receptor subunit beta
    Protein Accession:
    Q9Y5M8
    Secondary Accessions:
    • Q6P595
    • Q8N2D8

    Protein attributes for SRPRB Gene

    Size:
    271 amino acids
    Molecular mass:
    29702 Da
    Quaternary structure:
    • Heterodimer with SRPRA.

neXtProt entry for SRPRB Gene

Post-translational modifications for SRPRB Gene

  • Ubiquitination at Lys191, posLast=199199, posLast=230230, and Lys265
  • Modification sites at PhosphoSitePlus

Other Protein References for SRPRB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SRPRB Gene

Domains & Families for SRPRB Gene

Protein Domains for SRPRB Gene

Suggested Antigen Peptide Sequences for SRPRB Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y5M8

UniProtKB/Swiss-Prot:

SRPRB_HUMAN :
  • Belongs to the SRP receptor beta subunit family.
Family:
  • Belongs to the SRP receptor beta subunit family.
genes like me logo Genes that share domains with SRPRB: view

No data available for Gene Families for SRPRB Gene

Function for SRPRB Gene

Molecular function for SRPRB Gene

UniProtKB/Swiss-Prot Function:
Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity).

Gene Ontology (GO) - Molecular Function for SRPRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005047 signal recognition particle binding IBA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with SRPRB: view
genes like me logo Genes that share phenotypes with SRPRB: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SRPRB

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SRPRB

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SRPRB Gene

Localization for SRPRB Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRPRB Gene

Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRPRB gene
Compartment Confidence
cytoskeleton 5
endoplasmic reticulum 4
plasma membrane 2
cytosol 2
extracellular 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SRPRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IDA 19664239
GO:0005783 endoplasmic reticulum IEA --
GO:0005785 signal recognition particle receptor complex IBA --
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with SRPRB: view

Pathways & Interactions for SRPRB Gene

genes like me logo Genes that share pathways with SRPRB: view

Pathways by source for SRPRB Gene

Gene Ontology (GO) - Biological Process for SRPRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006614 SRP-dependent cotranslational protein targeting to membrane IBA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0036498 IRE1-mediated unfolded protein response TAS --
genes like me logo Genes that share ontologies with SRPRB: view

No data available for SIGNOR curated interactions for SRPRB Gene

Drugs & Compounds for SRPRB Gene

No Compound Related Data Available

Transcripts for SRPRB Gene

Unigene Clusters for SRPRB Gene

Signal recognition particle receptor, B subunit:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SRPRB

Alternative Splicing Database (ASD) splice patterns (SP) for SRPRB Gene

No ASD Table

Relevant External Links for SRPRB Gene

GeneLoc Exon Structure for
SRPRB
ECgene alternative splicing isoforms for
SRPRB

Expression for SRPRB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SRPRB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SRPRB Gene

This gene is overexpressed in Pancreas (x4.5).

Protein differential expression in normal tissues from HIPED for SRPRB Gene

This gene is overexpressed in Nasal epithelium (15.3) and Salivary gland (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SRPRB Gene



Protein tissue co-expression partners for SRPRB Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SRPRB Gene:

SRPRB

SOURCE GeneReport for Unigene cluster for SRPRB Gene:

Hs.12152

Evidence on tissue expression from TISSUES for SRPRB Gene

  • Liver(4.5)
  • Intestine(4.3)
  • Eye(4.2)
  • Nervous system(3.7)
  • Pancreas(2.9)
genes like me logo Genes that share expression patterns with SRPRB: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRPRB Gene

Orthologs for SRPRB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SRPRB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRPRB 34 35
  • 99.51 (n)
cow
(Bos Taurus)
Mammalia SRPRB 34 35
  • 90.41 (n)
dog
(Canis familiaris)
Mammalia SRPRB 34
  • 88.68 (n)
rat
(Rattus norvegicus)
Mammalia Srprb 34
  • 86.37 (n)
mouse
(Mus musculus)
Mammalia Srprb 34 16 35
  • 85.5 (n)
oppossum
(Monodelphis domestica)
Mammalia SRPRB 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRPRB 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves GGA.31975 35
  • 74 (a)
OneToOne
LOC101750392 34
  • 73.83 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia srprb 34
  • 67.33 (n)
MGC75930 34
African clawed frog
(Xenopus laevis)
Amphibia apmcf1-prov 34
zebrafish
(Danio rerio)
Actinopterygii srprb 34 35
  • 61.13 (n)
wufk57h10 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006688 34
  • 50.09 (n)
fruit fly
(Drosophila melanogaster)
Insecta SrpRbeta 34 35
  • 49.51 (n)
worm
(Caenorhabditis elegans)
Secernentea R186.3 34 35
  • 45.66 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SRP102 35
  • 25 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G05670 34
  • 47.34 (n)
rice
(Oryza sativa)
Liliopsida Os08g0524000 34
  • 47.59 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7092 35
  • 41 (a)
OneToOne
Species where no ortholog for SRPRB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRPRB Gene

ENSEMBL:
Gene Tree for SRPRB (if available)
TreeFam:
Gene Tree for SRPRB (if available)

Paralogs for SRPRB Gene

No data available for Paralogs for SRPRB Gene

Variants for SRPRB Gene

Sequence variations from dbSNP and Humsavar for SRPRB Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000175485 -- 133,818,420(+) TTGAC(A/G)AATTG intron-variant
rs1000227919 -- 133,784,916(+) GTATA(A/T)GTAGT intron-variant
rs1000247711 -- 133,818,104(+) TCTCT(G/T)GGATT intron-variant
rs1000277957 -- 133,798,337(+) TCTTT(C/T)GGCTG intron-variant
rs1000402282 -- 133,792,996(+) CAAAC(A/G)GATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRPRB Gene

Variant ID Type Subtype PubMed ID
dgv1408e212 CNV loss 25503493
dgv2604n106 CNV deletion 24896259
esv1005045 CNV deletion 20482838
esv1301210 CNV deletion 17803354
esv2661320 CNV deletion 23128226
esv2725943 CNV deletion 23290073
esv2833792 CNV deletion 24192839
esv3562578 CNV deletion 23714750
esv3892 CNV loss 18987735
esv8734 CNV loss 19470904
esv989994 CNV deletion 20482838
nsv1123691 CNV deletion 24896259
nsv4018 CNV deletion 18451855
nsv513074 CNV loss 21212237
nsv829729 CNV loss 17160897
nsv965212 CNV duplication 23825009

Variation tolerance for SRPRB Gene

Residual Variation Intolerance Score: 45.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.94; 74.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRPRB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRPRB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRPRB Gene

Disorders for SRPRB Gene

Relevant External Links for SRPRB

Genetic Association Database (GAD)
SRPRB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRPRB

No disorders were found for SRPRB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRPRB Gene

Publications for SRPRB Gene

  1. Genome-wide association study identifies two loci strongly affecting transferrin glycosylation. (PMID: 21665994) Kutalik Z. … Whitfield J.B. (Hum. Mol. Genet. 2011) 3 46 64
  2. Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels. (PMID: 19084217) Benyamin B. … Visscher P.M. (Am. J. Hum. Genet. 2009) 3 46 64
  3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for SRPRB Gene

  • Addgene plasmids for SRPRB

Sources for SRPRB Gene

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