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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SRPRB Gene

protein-coding   GIFtS: 54
GCID: GC03P133503

Signal Recognition Particle Receptor, B Subunit

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Signal Recognition Particle Receptor, B Subunit1 2
SR-beta2 3
APMCF12
Signal Recognition Particle Receptor Subunit Beta2
Signal Recognition Particle Receptor, Beta Subunit2
Protein APMCF13

External Ids:    HGNC: 240851   Entrez Gene: 584772   Ensembl: ENSG000001448677   UniProtKB: Q9Y5M83   

Export aliases for SRPRB gene to outside databases

Previous GC identifers: GC03P134845 GC03P135007 GC03P130882


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SRPRB Gene:
The protein encoded by this gene has similarity to mouse protein which is a subunit of the signal recognition
particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors
alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting
of both secretory and membrane proteins to the ER membrane. (provided by RefSeq, Jul 2008)

GeneCards Summary for SRPRB Gene: 
SRPRB (signal recognition particle receptor, B subunit) is a protein-coding gene. Diseases associated with SRPRB include conjunctivitis, and colon cancer, and among its related super-pathways are Activation of Chaperones by IRE1alpha and Viral mRNA Translation. GO annotations related to this gene include GTP binding.

UniProtKB/Swiss-Prot: SRPRB_HUMAN, Q9Y5M8
Function: Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal
recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum
membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity)

Gene Wiki entry for SRPRB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SRPRB gene promoter:
         STAT5B   Max1   C/EBPalpha   CHOP-10   Max   POU2F1   POU2F1b   POU2F1a   POU2F1c   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSRPRB promoter sequence
   Search SABiosciences Chromatin IP Primers for SRPRB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRPRB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22.1   Ensembl cytogenetic band:  3q22.1   HGNC cytogenetic band: 3q22.1

SRPRB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRPRB gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P133503:  view genomic region     (about GC identifiers)

Start:
133,502,877 bp from pter      End:
133,544,616 bp from pter
Size:
41,740 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SRPRB_HUMAN, Q9Y5M8 (See protein sequence)
Recommended Name: Signal recognition particle receptor subunit beta  
Size: 271 amino acids; 29702 Da
Subunit: Heterodimer with SRPR (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity)
Secondary accessions: Q6P595 Q8N2D8

Explore the universe of human proteins at neXtProt for SRPRB: NX_Q9Y5M8

Explore proteomics data for SRPRB at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y5M8

  • SRPRB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SRPRB Protein Expression
    REFSEQ proteins: NP_067026.3  
    ENSEMBL proteins: 
     ENSP00000418401   ENSP00000417096   ENSP00000417316  
    Reactome Protein details: Q9Y5M8
    Human Recombinant Protein Products for SRPRB: 
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    Browse Sino Biological Recombinant Proteins
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    Cloud-Clone Corp. Proteins for SRPRB 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005634nucleus ----
    GO:0005737cytoplasm IDA19664239
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005881cytoplasmic microtubule IDA--

    SRPRB for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR024156 Small_GTPase_ARF
     IPR019009 SRP_receptor_beta_su

    Graphical View of Domain Structure for InterPro Entry Q9Y5M8

    ProtoNet protein and cluster: Q9Y5M8

    UniProtKB/Swiss-Prot: SRPRB_HUMAN, Q9Y5M8
    Similarity: Belongs to the SRP receptor beta subunit family


    SRPRB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRPRB_HUMAN, Q9Y5M8
    Function: Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal
    recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum
    membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity ----
    GO:0005525GTP binding IEA--
    GO:0008199ferric iron binding IEA--
         
    SRPRB for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SRPRB:
     Increased circadian period len 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SRPRB 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SRPRB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SRPRB 
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    miRNA
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    miRTarBase miRNAs that target SRPRB:
    hsa-mir-16 (MIRT001408)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SRPRB
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate SRPRB (see all 25):
    hsa-miR-125a-5p hsa-miR-520e hsa-miR-302d hsa-miR-875-3p hsa-miR-302e hsa-miR-3692 hsa-miR-421 hsa-miR-520a-3p
    SwitchGear 3'UTR luciferase reporter plasmidSRPRB 3' UTR sequence
    Inhib. RNA
    Products:
        
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SRPRB About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Activation of Chaperone Genes by XBP1(S)
    Activation of Chaperones by IRE1alpha0.94
    Unfolded Protein Response0.76
    Activation of Chaperone Genes by XBP1(S)0.94
    2Viral mRNA Translation
    Translation0.78
    SRP-dependent cotranslational protein targeting to membrane0.77
    3Generic Transcription Pathway
    Gene Expression0.47
    4Asparagine N-linked glycosylation
    Metabolism of proteins0.35
    5Protein export
    Protein export

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5/7        Reactome Pathways for SRPRB (see all 7)
        Activation of Chaperone Genes by XBP1(S)
    Translation
    SRP-dependent cotranslational protein targeting to membrane
    Metabolism of proteins
    Activation of Chaperones by IRE1alpha


    1         Kegg Pathway  (Kegg details for SRPRB):
        Protein export


    SRPRB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SRPRB

    5/29 Interacting proteins for SRPRB (Q9Y5M82, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK5RAP3Q96JB52, 3MINT-65202 I2D: score=3 
    CASP4P496623I2D: score=2 
    NDNQ996083I2D: score=2 
    PTP4A3O753653I2D: score=2 
    TSC22D1Q157143I2D: score=2 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation TAS--
    GO:0006614SRP-dependent cotranslational protein targeting to membrane TAS--
    GO:0006826iron ion transport IEA--
    GO:0006879cellular iron ion homeostasis IEA--
    GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--

    SRPRB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SRPRB

    Search CenterWatch for drugs/clinical trials and news about SRPRB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SRPRB gene: 
    NM_021203.3  

    Unigene Cluster for SRPRB:

    Signal recognition particle receptor, B subunit
    Hs.12152  [show with all ESTs]
    Unigene Representative Sequence: NM_021203
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000466490(uc003epx.2) ENST00000484684 ENST00000494297 ENST00000481356
    ENST00000466636
    miRNA
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    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate SRPRB (see all 25):
    hsa-miR-125a-5p hsa-miR-520e hsa-miR-302d hsa-miR-875-3p hsa-miR-302e hsa-miR-3692 hsa-miR-421 hsa-miR-520a-3p
    SwitchGear 3'UTR luciferase reporter plasmidSRPRB 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRPRB

    Additional mRNA sequence: 

    AF086914.1 AF141882.3 AK027525.1 AK075531.1 BC019005.2 BC063001.1 BC065299.1 

    10 DOTS entries:

    DT.95141512  DT.100823286  DT.99975575  DT.100668148  DT.100712443  DT.100717751  DT.118107  DT.92433958 
    DT.95141496  DT.99940680 

    24/362 AceView cDNA sequences (see all 362):

    BM988490 AI075631 CA428973 BM760203 BU631203 BE326910 CB134534 AI341335 
    BU174769 BM978494 AU280386 BQ214915 CR621456 AA605034 BQ690682 CN483076 
    CA430686 BM997618 BQ018386 CA431446 BM708145 BE831465 CR619408 BQ771912 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SRPRB expression in normal human tissues (normalized intensities)      SRPRB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTGCTTGA
    SRPRB Expression
    About this image


    SRPRB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/25 selected tissues (see all 25) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Endochondral Facial Bones
             skeleton/cranium/viscerocranium   
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             kidney ; cells in tubules   
             renal vesicle e12.5   
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             oocyte   

    See SRPRB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SRPRB

    SOURCE GeneReport for Unigene cluster: Hs.12152
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SRPRB gene from 9/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srprb1 , 5 signal recognition particle receptor, B subunit1, 5 85.5(n)1
    91.08(a)1
      9 (55.00 cM)5
    208181  NM_009275.41  NP_033301.11 
     1031880335 
    chicken
    (Gallus gallus)
    Aves GGA.319756
    Uncharacterized protein
    74(a)
    1 ↔ 1
    9(4088880-4096004)
    African clawed frog
    (Xenopus laevis)
    Amphibia apmcf1-prov2 APMCF1 protein 75.73(n)    BC054231.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufk57h102 Transcribed sequence with weak similarity to protein more 74.8(n)    CK398604.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta SrpRbeta1 Signal recognition particle receptor beta 48.86(n)
    40.18(a)
      47283  NM_176307.2  NP_788485.1 
    worm
    (Caenorhabditis elegans)
    Secernentea R186.31 Protein R186.3 45.91(n)
    35.91(a)
      179781  NM_073844.3  NP_506245.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SRP1026
    Signal recognition particle (SRP) receptor beta su...
    25(a)
    1 ↔ 1
    XI(161601-162335)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G056701 signal recognition particle receptor subunit beta 46.64(n)
    36.7(a)
      830451  NM_120649.4  NP_196186.1 
    rice
    (Oryza sativa)
    Liliopsida Os08g05240001 hypothetical protein 48.05(n)
    37.39(a)
      4346082  NM_001068819.1  NP_001062284.1 


    ENSEMBL Gene Tree for SRPRB (if available)
    TreeFam Gene Tree for SRPRB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/798 SNPs in SRPRB are shown (see all 798)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1472263941,2
    C--133500912(+) TCATAA/CGGGAA 1 -- us2k10--------
    rs1815957041,2
    --133500992(+) TTAATC/TATAAA 1 -- us2k10--------
    rs780453141,2
    F--133500998(+) ATAAAC/TGTGGA 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1861145621,2
    --133501136(+) AGGGGA/TTATAC 1 -- us2k10--------
    rs1415777611,2
    C--133501266(+) TGTAT-/ACACACA 1 -- us2k10--------
    rs586113861,2
    C--133501267(+) ACACA-/AC/CA 
            
    ATGGA
    1 -- us2k10--------
    rs729743801,2
    C,F--133501349(+) ACTGGA/GGGATA 1 -- us2k12Minor allele frequency- G:0.06WA 120
    rs1405963941,2
    --133501377(+) GATACA/TGAAAG 1 -- us2k10--------
    rs1900927551,2
    --133501391(+) AATATC/TACACG 1 -- us2k10--------
    rs729743821,2
    C,F--133501396(+) TACACG/AATTTC 1 -- us2k12Minor allele frequency- A:0.10WA 120

    HapMap Linkage Disequilibrium report for SRPRB (133502877 - 133544616 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for SRPRB (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv3892CNV Deletion18987735
    esv2661320CNV Deletion23128226
    esv1005045CNV Deletion20482838
    esv2725943CNV Deletion23290073
    esv1301210CNV Deletion17803354
    esv989994CNV Deletion20482838
    nsv4018CNV Loss18451855
    nsv513074CNV Loss21212237
    nsv829729CNV Loss17160897
    esv8734CNV Loss19470904

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    3 diseases for SRPRB:    About MalaCards
    conjunctivitis    colon cancer    hepatocellular carcinoma


    SRPRB for disorders           About GeneDecksing

    Genetic Association Database (GAD): SRPRB

    Export disorders for SRPRB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SRPRB gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with SRPRB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study identifies two loci str ongly affecting transferrin glycosylation. (PubMed id 21665994)1, 4 Kutalik Z....Whitfield J.B. (2011)
    2. Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels. (PubMed id 19084217)1, 4 Benyamin B....Visscher P.M. (2009)
    3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The beta subunit of the signal recognition particle receptor is a transmembrane GTPase that anchors the alpha subunit, a peripheral membrane GTPase, to the endoplasmic reticulum membrane. (PubMed id 7844142)1, 3 Miller J.D....Walter P. (1995)
    7. Isolation of a novel member of small G protein superfamily and its expression in colon cancer. (PubMed id 12918107)1, 9 Yan W....Wang L. (2003)
    8. Nucleotide-dependent binding of the GTPase domain of the signal recognition particle receptor beta-subunit to the alpha-subunit. (PubMed id 10859309)3, 9 Legate K.R....Andrews D.W. (2000)
    9. Novel, gel-free proteomics approach identifies RNF5 an d JAMP as modulators of GPCR stability. (PubMed id 23798571)1 Roy S.J....Parent J.L. (2013)
    10. Characterization of carbonic anhydrase IX interactome reveals proteins assisting its nuclear localization in hypoxic cells. (PubMed id 23181366)1 Buanne P....Zambrano N. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 58477 HGNC: 24085 AceView: SRPRB Ensembl:ENSG00000144867 euGenes: HUgn58477
    ECgene: SRPRB Kegg: 58477 H-InvDB: SRPRB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SRPRB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SRPRB gene:
    Search GeneIP for patents involving SRPRB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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