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Aliases for SRPRB Gene

Aliases for SRPRB Gene

  • SRP Receptor Beta Subunit 2 3 5
  • Signal Recognition Particle Receptor, B Subunit 2 3
  • SR-Beta 3 4
  • Signal Recognition Particle Receptor, Beta Subunit 3
  • Protein APMCF1 4
  • APMCF1 3

External Ids for SRPRB Gene

Previous GeneCards Identifiers for SRPRB Gene

  • GC03P134845
  • GC03P135007
  • GC03P133503
  • GC03P130882
  • GC03P133505

Summaries for SRPRB Gene

Entrez Gene Summary for SRPRB Gene

  • The protein encoded by this gene has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and membrane proteins to the ER membrane. [provided by RefSeq, Jul 2008]

GeneCards Summary for SRPRB Gene

SRPRB (SRP Receptor Beta Subunit) is a Protein Coding gene. Among its related pathways are Protein export and Gene Expression. GO annotations related to this gene include GTP binding and GTPase activity.

UniProtKB/Swiss-Prot for SRPRB Gene

  • Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity).

Gene Wiki entry for SRPRB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRPRB Gene

Genomics for SRPRB Gene

Regulatory Elements for SRPRB Gene

Enhancers for SRPRB Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SRPRB on UCSC Golden Path with GeneCards custom track

Genomic Location for SRPRB Gene

Chromosome:
3
Start:
133,784,033 bp from pter
End:
133,825,772 bp from pter
Size:
41,740 bases
Orientation:
Plus strand

Genomic View for SRPRB Gene

Genes around SRPRB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRPRB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRPRB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRPRB Gene

Proteins for SRPRB Gene

  • Protein details for SRPRB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5M8-SRPRB_HUMAN
    Recommended name:
    Signal recognition particle receptor subunit beta
    Protein Accession:
    Q9Y5M8
    Secondary Accessions:
    • Q6P595
    • Q8N2D8

    Protein attributes for SRPRB Gene

    Size:
    271 amino acids
    Molecular mass:
    29702 Da
    Quaternary structure:
    • Heterodimer with SRPRA.

neXtProt entry for SRPRB Gene

Proteomics data for SRPRB Gene at MOPED

Post-translational modifications for SRPRB Gene

  • Ubiquitination at Lys 191, Lys 199, Lys 230, and Lys 265
  • Modification sites at PhosphoSitePlus

Other Protein References for SRPRB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SRPRB Gene

Domains & Families for SRPRB Gene

Protein Domains for SRPRB Gene

Suggested Antigen Peptide Sequences for SRPRB Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y5M8

UniProtKB/Swiss-Prot:

SRPRB_HUMAN :
  • Belongs to the SRP receptor beta subunit family.
Family:
  • Belongs to the SRP receptor beta subunit family.
genes like me logo Genes that share domains with SRPRB: view

No data available for Gene Families for SRPRB Gene

Function for SRPRB Gene

Molecular function for SRPRB Gene

UniProtKB/Swiss-Prot Function:
Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity).
genes like me logo Genes that share phenotypes with SRPRB: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SRPRB

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SRPRB Gene

Localization for SRPRB Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRPRB Gene

Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRPRB Gene COMPARTMENTS Subcellular localization image for SRPRB gene
Compartment Confidence
cytoskeleton 5
endoplasmic reticulum 4
cytosol 2
plasma membrane 2
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SRPRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 19664239
GO:0005785 signal recognition particle receptor complex IBA --
genes like me logo Genes that share ontologies with SRPRB: view

Pathways & Interactions for SRPRB Gene

genes like me logo Genes that share pathways with SRPRB: view

Pathways by source for SRPRB Gene

Gene Ontology (GO) - Biological Process for SRPRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030968 endoplasmic reticulum unfolded protein response TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with SRPRB: view

No data available for SIGNOR curated interactions for SRPRB Gene

Drugs & Compounds for SRPRB Gene

No Compound Related Data Available

Transcripts for SRPRB Gene

Unigene Clusters for SRPRB Gene

Signal recognition particle receptor, B subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SRPRB Gene

No ASD Table

Relevant External Links for SRPRB Gene

GeneLoc Exon Structure for
SRPRB
ECgene alternative splicing isoforms for
SRPRB

Expression for SRPRB Gene

mRNA expression in normal human tissues for SRPRB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SRPRB Gene

This gene is overexpressed in Pancreas (x4.5).

Protein differential expression in normal tissues from HIPED for SRPRB Gene

This gene is overexpressed in Nasal epithelium (15.3) and Salivary gland (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SRPRB Gene



SOURCE GeneReport for Unigene cluster for SRPRB Gene Hs.12152

genes like me logo Genes that share expression patterns with SRPRB: view

Protein tissue co-expression partners for SRPRB Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SRPRB Gene

Orthologs for SRPRB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SRPRB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SRPRB 35
  • 90.41 (n)
  • 92.62 (a)
SRPRB 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRPRB 35
  • 88.68 (n)
  • 92.99 (a)
mouse
(Mus musculus)
Mammalia Srprb 35
  • 85.5 (n)
  • 91.08 (a)
Srprb 16
Srprb 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SRPRB 35
  • 99.51 (n)
  • 99.26 (a)
SRPRB 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Srprb 35
  • 86.37 (n)
  • 91.45 (a)
oppossum
(Monodelphis domestica)
Mammalia SRPRB 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRPRB 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC101750392 35
  • 73.83 (n)
  • 74.61 (a)
GGA.31975 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75930 35
srprb 35
  • 67.33 (n)
  • 66.14 (a)
African clawed frog
(Xenopus laevis)
Amphibia apmcf1-prov 35
zebrafish
(Danio rerio)
Actinopterygii srprb 35
  • 61.13 (n)
  • 59.51 (a)
wufk57h10 35
srprb 36
  • 56 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006688 35
  • 50.09 (n)
  • 44.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta SrpRbeta 35
  • 49.51 (n)
  • 40.78 (a)
SrpRbeta 36
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea R186.3 35
  • 45.66 (n)
  • 36.46 (a)
R186.3 36
  • 33 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SRP102 36
  • 25 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G05670 35
  • 47.34 (n)
  • 38.3 (a)
rice
(Oryza sativa)
Liliopsida Os08g0524000 35
  • 47.59 (n)
  • 37.11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7092 36
  • 41 (a)
OneToOne
Species with no ortholog for SRPRB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRPRB Gene

ENSEMBL:
Gene Tree for SRPRB (if available)
TreeFam:
Gene Tree for SRPRB (if available)

Paralogs for SRPRB Gene

No data available for Paralogs for SRPRB Gene

Variants for SRPRB Gene

Sequence variations from dbSNP and Humsavar for SRPRB Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_057335 -
rs9817549 -- 133,819,036(+) AGGGG(A/C)CTTAC intron-variant
rs7615183 -- 133,816,385(+) TTATT(A/G)TTTAT intron-variant
rs6762254 -- 133,809,343(+) GATGT(A/G)GATGG intron-variant
rs1464937 -- 133,817,811(+) AGTTG(C/G)GAGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRPRB Gene

Variant ID Type Subtype PubMed ID
nsv877506 CNV Gain 21882294
nsv829729 CNV Loss 17160897
nsv4018 CNV Loss 18451855
esv1005045 CNV Deletion 20482838
nsv513074 CNV Loss 21212237
esv3892 CNV Deletion 18987735
esv8734 CNV Loss 19470904
esv2725943 CNV Deletion 23290073
esv2661320 CNV Deletion 23128226
esv989994 CNV Deletion 20482838
esv1301210 CNV Deletion 17803354

Variation tolerance for SRPRB Gene

Residual Variation Intolerance Score: 45.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.94; 74.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRPRB Gene

HapMap Linkage Disequilibrium report
SRPRB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRPRB Gene

Disorders for SRPRB Gene

Relevant External Links for SRPRB

Genetic Association Database (GAD)
SRPRB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRPRB

No disorders were found for SRPRB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRPRB Gene

Publications for SRPRB Gene

  1. Genome-wide association study identifies two loci strongly affecting transferrin glycosylation. (PMID: 21665994) Kutalik Z. … Whitfield J.B. (Hum. Mol. Genet. 2011) 3 48 67
  2. Isolation of a novel member of small G protein superfamily and its expression in colon cancer. (PMID: 12918107) Yan W. … Wang L. (World J. Gastroenterol. 2003) 3 23
  3. Nucleotide-dependent binding of the GTPase domain of the signal recognition particle receptor beta-subunit to the alpha-subunit. (PMID: 10859309) Legate K.R. … Andrews D.W. (J. Biol. Chem. 2000) 2 23
  4. The beta subunit of the signal recognition particle receptor is a transmembrane GTPase that anchors the alpha subunit, a peripheral membrane GTPase, to the endoplasmic reticulum membrane. (PMID: 7844142) Miller J.D. … Walter P. (J. Cell Biol. 1995) 2 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for SRPRB Gene

Sources for SRPRB Gene

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