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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SRPRB Gene

protein-coding   GIFtS: 51
GCID: GC03P133503

signal recognition particle receptor, B subunit
 Explore 5 diseases affiliated with
SRPRB via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SRPRB    

Aliases
for SRPRB gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Signal Recognition Particle Receptor, B Subunit1 2
APMCF11 2
SR-Beta1
Signal Recognition Particle Receptor Subunit Beta2
Signal Recognition Particle Receptor, Beta Subunit2
Protein APMCF13

External Ids:    HGNC: 240851   Entrez Gene: 584772   Ensembl: ENSG000001448677   UniProtKB: Q9Y5M83   

Export aliases for SRPRB gene to outside databases

Previous GC identifers: GC03P134845 GC03P135007 GC03P130882


Summaries
for SRPRB gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SRPRB:
The protein encoded by this gene has similarity to mouse protein which is a subunit of the signal recognition particle
receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a
peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and
membrane proteins to the ER membrane. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SRPRB_HUMAN, Q9Y5M8
Function: Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal
recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane
system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity)

Gene Wiki entry for SRPRB


Genomic Views
for SRPRB gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SRPRB gene promoter:
         STAT5B   Max1   C/EBPalpha   CHOP-10   Max   POU2F1   POU2F1b   POU2F1a   POU2F1c   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SRPRB promoter sequence
   Search SABiosciences Chromatin IP Primers for SRPRB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRPRB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22.1   Ensembl cytogenetic band:  3q22.1   HGNC cytogenetic band: 3q22.1

SRPRB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRPRB gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P133503:  view genomic region     (about GC identifiers)

Start:
 133,502,877 bp from pter      End:
 133,544,616 bp from pter
Size:
 41,740 bases      Orientation:
 plus strand

Proteins
for SRPRB gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SRPRB_HUMAN, Q9Y5M8 (See protein sequence)
Recommended Name: Signal recognition particle receptor subunit beta  
Size: 271 amino acids; 29702 Da
Subunit: Heterodimer with SRPR (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity)
Secondary accessions: Q6P595 Q8N2D8

Explore the universe of human proteins at neXtProt for SRPRB: NX_Q9Y5M8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y5M8

    • SRPRB Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_067026.3  
    ENSEMBL proteins: 
     ENSP00000418401   ENSP00000417096   ENSP00000417316  
    Reactome Protein details: Q9Y5M8
    Human Recombinant Protein Products: 
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: SRPRB
    OriGene Protein Over-expression Lysate: SRPRB
    OriGene Custom Protein Services for SRPRB 
    GenScript Custom Purified and Recombinant Proteins Services for SRPRB
    Novus Biologicals SRPRB Protein
    Novus Biologicals SRPRB Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SRPRB

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA19664239
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral to membrane IEA--


    SRPRB for ontologies           About GeneDecksing



    SRPRB Antibody Products: 
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    Uscn ELISAs and CLIAs for SRPRB

    Protein Domains /
    Families
    for SRPRB gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SRPRB for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR024156 Small_GTPase_ARF
     IPR019009 SRP_receptor_beta_su

    Graphical View of Domain Structure for InterPro Entry Q9Y5M8

    ProtoNet protein and cluster: Q9Y5M8

    UniProtKB/Swiss-Prot: SRPRB_HUMAN, Q9Y5M8
    Similarity: Belongs to the SRP receptor beta subunit family


    Function
    for SRPRB gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SRPRB_HUMAN, Q9Y5M8
    Function: Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal
    recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane
    system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity)

    miRNA
    Products:            		miRTarBase miRNAs that target SRPRB:
    hsa-mir-16 (MIRT001408)

    OriGene 3'-UTR Clone: SRPRB
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SRPRB
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate SRPRB (see all 25):
    hsa-miR-125a-5p hsa-miR-520e hsa-miR-302d hsa-miR-875-3p hsa-miR-302e hsa-miR-3692 hsa-miR-421 hsa-miR-520a-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SRPRB 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SRPRB (see all 7)
    OriGene shRNA RFP: SRPRB
    OriGene siRNA: SRPRB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRPRB

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SRPRB

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRPRB (see all 3)
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    GenScript: all cDNA clones in your preferred vector: SRPRB (NM_021203)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRPRB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRPRB 

    Cell Line
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    Search LifeMap BioReagents cell lines for SRPRB

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRPRB

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity ----
    GO:0005525GTP binding IEA--


    SRPRB for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SRPRB:
     Increased circadian period len 


    Pathways & Interactions
    for SRPRB gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Activation of Chaperone Genes by XBP1(S)
    		Activation of Chaperone Genes by XBP1(S)1.00
    		Unfolded Protein Response0.71
    		Activation of Chaperones by IRE1alpha0.94
    2Synthesis of PB1-F2
    		SRP-dependent cotranslational protein targeting to membrane0.77
    		Translation0.57
    3Expression of SRPRB (SRP Receptor subunit beta)
    		Expression of SRPRB (SRP Receptor subunit beta)1.00
    4Protein export
    		Protein export1.00
    5Generic Transcription Pathway
    		Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/8        Reactome Pathways for SRPRB (see all 8)
        Activation of Chaperone Genes by XBP1(S)
    Expression of SRPRB (SRP Receptor subunit beta)
    Translation
    SRP-dependent cotranslational protein targeting to membrane
    Metabolism of proteins


    1         Kegg Pathway  (Kegg details for SRPRB):
        Protein export


    SRPRB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SRPRB

    5/29 Interacting proteins for SRPRB (Q9Y5M82, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK5RAP3Q96JB52, 3MINT-65202 I2D: score=3 
    CASP4P496623I2D: score=2 
    NDNQ996083I2D: score=2 
    PTP4A3O753653I2D: score=2 
    TSC22D1Q157143I2D: score=2 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation TAS--
    GO:0006614SRP-dependent cotranslational protein targeting to membrane TAS--
    GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0010467gene expression TAS--


    SRPRB for ontologies           About GeneDecksing



    Drugs & Compounds
    for SRPRB gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SRPRB
    Search CenterWatch for drugs/clinical trials and news about SRPRB 

    Transcripts
    for SRPRB gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SRPRB gene: 
    NM_021203.3  

    Unigene Cluster for SRPRB:

    Signal recognition particle receptor, B subunit
    Hs.12152  [show with all ESTs]
    Unigene Representative Sequence: NM_021203
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000466490(uc003epx.2) ENST00000484684 ENST00000494297 ENST00000481356
    ENST00000466636

    miRNA
    Products:             		 OriGene 3'-UTR Clone: SRPRB
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SRPRB
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate SRPRB (see all 25):
    hsa-miR-125a-5p hsa-miR-520e hsa-miR-302d hsa-miR-875-3p hsa-miR-302e hsa-miR-3692 hsa-miR-421 hsa-miR-520a-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SRPRB 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SRPRB (see all 7)
    OriGene shRNA RFP: SRPRB
    OriGene siRNA: SRPRB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRPRB
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRPRB
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SRPRB (NM_021203)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRPRB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRPRB 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SRPRB
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SRPRB
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRPRB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRPRB

    Additional cDNA sequence: 

    AF086914.1 AF141882.3 AK027525.1 AK075531.1 BC019005.2 BC063001.1 BC065299.1 

    9 DOTS entries:

    DT.95141512  DT.100823286  DT.99975575  DT.100668148  DT.100712443  DT.118107  DT.95141496  DT.99940680 
    DT.92433958 

    24/362 AceView cDNA sequences (see all 362):

    BQ771912 AA402059 CA430686 AI372913 CB113725 BM988490 BQ890586 CA430328 
    BM997618 BC019005 AI341335 BU174769 BU190821 AA846244 BQ884022 AF141882 
    BQ877189 BP340826 BM708898 BU147468 CB162069 BM738328 BF969683 AI627467 

    GeneLoc Exon Structure


    Expression
    for SRPRB gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SRPRB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGCTGCTTGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SRPRB expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneEndochondral Facial BonesBone
    BoneStylopod Long BoneBone
    BoneThoracic RibBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SRPRB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SRPRB

    SOURCE GeneReport for Unigene cluster: Hs.12152
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    In Situ
    Assay Products:     
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    Orthologs
    for SRPRB gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SRPRB gene from 7/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Srprb1 , 5 signal recognition particle receptor, B subunit1, 5 85.5(n)1
    91.08(a)1    		   9 (55.00 cM)5
    208181  NM_009275.41  NP_033301.11 
     1031880335 
    African clawed frog
    (Xenopus laevis)    		 Amphibia apmcf1-prov2 APMCF1 protein 75.73(n)    BC054231.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufk57h102 Transcribed sequence with weak similarity to protein more 74.8(n)    CK398604.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta SrpRbeta1 Signal recognition particle receptor beta 48.86(n)
    40.18(a)    		   47283  NM_176307.2  NP_788485.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea R186.31 Protein R186.3 45.91(n)
    35.91(a)    		   179781  NM_073844.3  NP_506245.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT5G056701 signal recognition particle receptor subunit beta 46.64(n)
    36.7(a)    		   830451  NM_120649.4  NP_196186.1 
    rice
    (Oryza sativa)    		 Liliopsida Os08g05240001 hypothetical protein 48.05(n)
    37.39(a)    		   4346082  NM_001068819.1  NP_001062284.1 


    ENSEMBL Gene Tree for SRPRB (if available)
    TreeFam Gene Tree for SRPRB (if available) 

    Paralogs
    for SRPRB gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for SRPRB gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/628 NCBI SNPs in SRPRB are shown (see all 628)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1472263941,2
    		--133500912(+) TCATAA/CGGGAA 1 -- us2k10--------
    rs1815957041,2
    		--133500992(+) TTAATC/TATAAA 1 -- us2k10--------
    rs780453141,2
    		--133500998(+) ATAAAC/TGTGGA 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1861145621,2
    		--133501136(+) AGGGGA/TTATAC 1 -- us2k10--------
    rs1415777611,2
    		C,--133501266(+) TGTAT-/ACACACA 1 -- us2k10--------
    rs586113861,2
    		C--133501285(+) ACACA-/CAATGGA 1 -- us2k10--------
    rs729743801,2
    		C,--133501349(+) ACTGGA/GGGATA 1 -- us2k12Minor allele frequency- G:0.06WA 120
    rs1405963941,2
    		--133501377(+) GATACA/TGAAAG 1 -- us2k10--------
    rs1900927551,2
    		--133501391(+) AATATC/TACACG 1 -- us2k10--------
    rs729743821,2
    		C,--133501396(+) TACACG/AATTTC 1 -- us2k12Minor allele frequency- A:0.10WA 120

    HapMap Linkage Disequilibrium report for SRPRB (133502877 - 133544616 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for SRPRB
         3 CNVs: 43341 23663 62104

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SRPRB
    DNA2.0 Custom Variant and Variant Library Synthesis for SRPRB

    Disorders / Diseases
    for SRPRB gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SRPRB for disorders           About GeneDecksing

    5 diseases for SRPRB:    About MalaCards
    conjunctivitis    hepatocellular carcinoma    colon cancer    carcinoma
    malaria


    Export disorders for SRPRB gene to outside databases

    Publications
    for SRPRB gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SRPRB gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with SRPRB)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The beta subunit of the signal recognition particle receptor is a transmembrane GTPase that anchors the alpha subunit, a peripheral membrane GTPase, to the endoplasmic reticulum membrane. (PubMed id 7844142)1, 3 Miller J.D....Walter P. (1995)
    5. Isolation of a novel member of small G protein superfamily and its expression in colon cancer. (PubMed id 12918107)1, 9 Yan W....Wang L. (2003)
    6. Nucleotide-dependent binding of the GTPase domain of the signal recognition particle receptor beta-subunit to the alpha-subunit. (PubMed id 10859309)3, 9 Legate K.R....Andrews D.W. (2000)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. Membrane-associated ubiquitin ligase complex containi ng gp78 mediates sterol-accelerated degradation of 3-hydroxy-3-methylglutaryl-c oenzyme A reductase. (PubMed id 21343306)1 Jo Y....DeBose-Boyd R.A. (2011)

    External Searches for SRPRB gene

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    Genome Databases showing SRPRB gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 58477 HGNC: 24085 AceView: SRPRB Ensembl:ENSG00000144867 euGenes: HUgn58477
    ECgene: SRPRB Kegg: 58477 H-InvDB: SRPRB

    Other Databases showing SRPRB gene

    (According to HUGE)
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    Specialized Databases showing SRPRB gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SRPRB Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SRPRB gene

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    IP news from LifeMap Sciences, Inc.)
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