Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SRPRB Gene

protein-coding   GIFtS: 53
GCID: GC03P133505

Signal Recognition Particle Receptor, B Subunit

  Search for SRPRB
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Signal Recognition Particle Receptor, B Subunit1 2
SR-beta2 3
APMCF12
Signal Recognition Particle Receptor Subunit Beta2
Signal Recognition Particle Receptor, Beta Subunit2
Protein APMCF13

External Ids:    HGNC: 240851   Entrez Gene: 584772   Ensembl: ENSG000001448677   UniProtKB: Q9Y5M83   

Export aliases for SRPRB gene to outside databases

Previous GC identifers: GC03P134845 GC03P135007 GC03P133503 GC03P130882


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SRPRB Gene:
The protein encoded by this gene has similarity to mouse protein which is a subunit of the signal recognition
particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors
alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting
of both secretory and membrane proteins to the ER membrane. (provided by RefSeq, Jul 2008)

GeneCards Summary for SRPRB Gene:
SRPRB (signal recognition particle receptor, B subunit) is a protein-coding gene. GO annotations related to this gene include ferric iron binding and GTP binding.

UniProtKB/Swiss-Prot: SRPRB_HUMAN, Q9Y5M8
Function: Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal
recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum
membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity)

Gene Wiki entry for SRPRB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the SRPRB gene promoter:
         STAT5B   Max1   C/EBPalpha   CHOP-10   Max   POU2F1   POU2F1b   POU2F1a   POU2F1c   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSRPRB promoter sequence
   Search Chromatin IP Primers for SRPRB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SRPRB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22.1   Ensembl cytogenetic band:  3q22.1   HGNC cytogenetic band: 3q22.1

SRPRB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRPRB gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P133505:  view genomic region     (about GC identifiers)

Start:
133,502,877 bp from pter      End:
133,544,616 bp from pter
Size:
41,740 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SRPRB_HUMAN, Q9Y5M8 (See protein sequence)
Recommended Name: Signal recognition particle receptor subunit beta  
Size: 271 amino acids; 29702 Da
Subunit: Heterodimer with SRPR (By similarity)
Secondary accessions: Q6P595 Q8N2D8

Explore the universe of human proteins at neXtProt for SRPRB: NX_Q9Y5M8

Explore proteomics data for SRPRB at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys191, Lys199, Lys230, Lys265
  • Modification sites at PhosphoSitePlus

  • See SRPRB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_067026.3  
    ENSEMBL proteins: 
     ENSP00000418401   ENSP00000417096   ENSP00000417316  
    Reactome Protein details: Q9Y5M8

    SRPRB Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SRPRB
    OriGene Protein Over-expression Lysate for SRPRB
    OriGene MassSpec for SRPRB
    OriGene Custom Protein Services for SRPRB
    GenScript Custom Purified and Recombinant Proteins Services for SRPRB
    Novus Biologicals SRPRB Protein
    Novus Biologicals SRPRB Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SRPRB

     
    Search eBioscience for Proteins for SRPRB 

    SRPRB Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SRPRB
    OriGene Custom Antibody Services for SRPRB
    Novus Biologicals SRPRB Antibodies
    Search for Antibodies for SRPRB at Abcam
    Cloud-Clone Corp. Antibodies for SRPRB
    Search ThermoFisher Antibodies for SRPRB
    LSBio Antibodies in human, mouse, rat for SRPRB

    SRPRB Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SRPRB
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SRPRB
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SRPRB
    Cloud-Clone Corp. CLIAs for SRPRB
    Search eBioscience for ELISAs for SRPRB 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR024156 Small_GTPase_ARF
     IPR019009 SRP_receptor_beta_su

    Graphical View of Domain Structure for InterPro Entry Q9Y5M8

    ProtoNet protein and cluster: Q9Y5M8

    UniProtKB/Swiss-Prot: SRPRB_HUMAN, Q9Y5M8
    Similarity: Belongs to the SRP receptor beta subunit family


    Find genes that share domains with SRPRB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRPRB_HUMAN, Q9Y5M8
    Function: Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal
    recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum
    membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity ----
    GO:0005525GTP binding IEA--
         
    Find genes that share ontologies with SRPRB           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SRPRB:
     Increased circadian period len 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SRPRB
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SRPRB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SRPRB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SRPRB

    miRNA
    Products:
        
    miRTarBase miRNAs that target SRPRB:
    hsa-mir-16-5p (MIRT001408), hsa-mir-92a-3p (MIRT049089)

    Block miRNA regulation of human, mouse, rat SRPRB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SRPRB (see all 25):
    hsa-miR-125a-5p hsa-miR-520e hsa-miR-302d hsa-miR-875-3p hsa-miR-302e hsa-miR-3692 hsa-miR-421 hsa-miR-520a-3p
    SwitchGear 3'UTR luciferase reporter plasmidSRPRB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SRPRB
    Predesigned siRNA for gene silencing in human, mouse, rat SRPRB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SRPRB

    Clone
    Products:
         
    OriGene clones in human, mouse for SRPRB (see all 7)
    OriGene ORF clones in mouse, rat for SRPRB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SRPRB (NM_021203)
    Sino Biological Human cDNA Clone for SRPRB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRPRB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRPRB
    Addgene plasmids for SRPRB 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SRPRB
    Browse ESI BIO Cell Lines and PureStem Progenitors for SRPRB 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRPRB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SRPRB_HUMAN, Q9Y5M8: Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    endoplasmic reticulum5
    cytosol2
    extracellular1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm IDA19664239
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005881cytoplasmic microtubule IDA--
    GO:0016020membrane IDA--

    Find genes that share ontologies with SRPRB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SRPRB About    
    See pathways by source

    SuperPathContained pathways About
    1Unfolded Protein Response
    Unfolded Protein Response0.61
    Activation of Chaperone Genes by XBP1(S)0.59
    Activation of Chaperones by IRE1alpha0.61
    2Influenza Viral RNA Transcription and Replication
    SRP-dependent cotranslational protein targeting to membrane0.83
    Translation0.82
    3Gene Expression
    Gene Expression0.40
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    5Protein export
    Protein export


    Find genes that share SuperPaths with SRPRB           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for SRPRB
        XBP1(S) activates chaperone genes
    SRP-dependent cotranslational protein targeting to membrane


    1 Kegg Pathway  (Kegg details for SRPRB):
        Protein export

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SRPRB
    Interactions:

        GeneGlobe Interaction Network for SRPRB

    Selected Interacting proteins for SRPRB (Q9Y5M82, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK5RAP3Q96JB52, 3MINT-65202 I2D: score=3 
    CASP4P496623I2D: score=2 
    NDNQ996083I2D: score=2 
    PTP4A3O753653I2D: score=2 
    TSC22D1Q157143I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation TAS--
    GO:0006614SRP-dependent cotranslational protein targeting to membrane TAS--
    GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0010467gene expression TAS--

    Find genes that share ontologies with SRPRB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SRPRB



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SRPRB gene: 
    NM_021203.3  

    Unigene Cluster for SRPRB:

    Signal recognition particle receptor, B subunit
    Hs.12152  [show with all ESTs]
    Unigene Representative Sequence: NM_021203
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000466490(uc003epx.2) ENST00000484684 ENST00000494297 ENST00000481356
    ENST00000466636
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SRPRB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SRPRB (see all 25):
    hsa-miR-125a-5p hsa-miR-520e hsa-miR-302d hsa-miR-875-3p hsa-miR-302e hsa-miR-3692 hsa-miR-421 hsa-miR-520a-3p
    SwitchGear 3'UTR luciferase reporter plasmidSRPRB 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SRPRB
    Predesigned siRNA for gene silencing in human, mouse, rat SRPRB
    Clone
    Products:
         
    OriGene clones in human, mouse for SRPRB (see all 7)
    OriGene ORF clones in mouse, rat for SRPRB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SRPRB (NM_021203)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRPRB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRPRB
    Addgene plasmids for SRPRB 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SRPRB
    OriGene qSTAR qPCR primer pairs in human, mouse for SRPRB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SRPRB
      QuantiTect SYBR Green Assays in human, mouse, rat SRPRB
      QuantiFast Probe-based Assays in human, mouse, rat SRPRB

    Additional mRNA sequence: 

    AF086914.1 AF141882.3 AK027525.1 AK075531.1 BC019005.2 BC063001.1 BC065299.1 

    10 DOTS entries:

    DT.95141512  DT.100823286  DT.99975575  DT.100668148  DT.100712443  DT.100717751  DT.118107  DT.92433958 
    DT.95141496  DT.99940680 

    Selected AceView cDNA sequences (see all 362):

    AA948078 BM708145 BM708898 AA402059 BE672814 BQ690682 BU631203 BC065299 
    AI627467 BM997618 AW087345 CB162069 BE831465 CB113749 AI075631 BQ877189 
    BM738328 BP340826 AI372913 Z38515 Z39863 CA443919 AA188821 AA494532 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SRPRB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTGCTTGA
    SRPRB Expression
    About this image


    SRPRB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Endochondral Facial Bones
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Pancreas (Endocrine System)
    SRPRB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SRPRB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.12152
        Custom PCR Arrays for SRPRB
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SRPRB
    OriGene qSTAR qPCR primer pairs in human, mouse for SRPRB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SRPRB
    QuantiTect SYBR Green Assays in human, mouse, rat SRPRB
    QuantiFast Probe-based Assays in human, mouse, rat SRPRB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRPRB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SRPRB gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srprb1 , 5 signal recognition particle receptor, B subunit1, 5 85.5(n)1
    91.08(a)1
      9 (55.00 cM)5
    208181  NM_009275.41  NP_033301.11 
     1031880335 
    chicken
    (Gallus gallus)
    Aves LOC1017503921 signal recognition particle receptor subunit beta-like 73.83(n)
    74.61(a)
      101750392  XM_004936994.1  XP_004937051.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia apmcf1-prov2 APMCF1 protein 75.73(n)    BC054231.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufk57h102 Transcribed sequence with weak similarity to protein more 74.8(n)    CK398604.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta SrpRbeta1 Signal recognition particle receptor beta 49.51(n)
    40.78(a)
      47283  NM_176307.3  NP_788485.1 
    worm
    (Caenorhabditis elegans)
    Secernentea R186.31 R186.3 45.66(n)
    36.46(a)
      179781  NM_073844.4  NP_506245.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SRP1026
    Signal recognition particle (SRP) receptor beta su...
    25(a)
    1 ↔ 1
    XI(161601-162335) YKL154W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G056701 AT5G05670 47.34(n)
    38.3(a)
      830451  NM_203006.2  NP_974735.1 
    rice
    (Oryza sativa)
    Liliopsida Os08g05240001 Os08g0524000 47.59(n)
    37.11(a)
      4346082  NM_001068819.1  NP_001062284.1 


    ENSEMBL Gene Tree for SRPRB (if available)
    TreeFam Gene Tree for SRPRB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SRPRB (see all 798)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1472263941,2
    C--133500912(+) TCATAA/CGGGAA 1 -- us2k10--------
    rs1815957041,2
    --133500992(+) TTAATC/TATAAA 1 -- us2k10--------
    rs780453141,2
    F--133500998(+) ATAAAC/TGTGGA 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1861145621,2
    --133501136(+) AGGGGA/TTATAC 1 -- us2k10--------
    rs1415777611,2
    C--133501266(+) TGTAT-/ACACACA 1 -- us2k10--------
    rs586113861,2
    C--133501267(+) ACACA-/AC/CA 
            
    ATGGA
    1 -- us2k10--------
    rs729743801,2
    C,F--133501349(+) ACTGGA/GGGATA 1 -- us2k12Minor allele frequency- G:0.06WA 120
    rs1405963941,2
    --133501377(+) GATACA/TGAAAG 1 -- us2k10--------
    rs1900927551,2
    --133501391(+) AATATC/TACACG 1 -- us2k10--------
    rs729743821,2
    C,F--133501396(+) TACACG/AATTTC 1 -- us2k12Minor allele frequency- A:0.10WA 120

    HapMap Linkage Disequilibrium report for SRPRB (133502877 - 133544616 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SRPRB (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv3892CNV Deletion18987735
    esv2661320CNV Deletion23128226
    esv1005045CNV Deletion20482838
    esv2725943CNV Deletion23290073
    esv1301210CNV Deletion17803354
    esv989994CNV Deletion20482838
    nsv4018CNV Loss18451855
    nsv513074CNV Loss21212237
    nsv829729CNV Loss17160897
    esv8734CNV Loss19470904

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SRPRB
    DNA2.0 Custom Variant and Variant Library Synthesis for SRPRB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus

    Find genes that share disorders with SRPRB           About GenesLikeMe

    Genetic Association Database (GAD): SRPRB

    Export disorders for SRPRB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SRPRB gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with SRPRB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study identifies two loci strongly affecting transferrin glycosylation. (PubMed id 21665994)1, 4 Kutalik Z....Whitfield J.B. (Hum. Mol. Genet. 2011)
    2. Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels. (PubMed id 19084217)1, 4 Benyamin B....Visscher P.M. (Am. J. Hum. Genet. 2009)
    3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The beta subunit of the signal recognition particle receptor is a transmembrane GTPase that anchors the alpha subunit, a peripheral membrane GTPase, to the endoplasmic reticulum membrane. (PubMed id 7844142)1, 3 Miller J.D....Walter P. (J. Cell Biol. 1995)
    7. Isolation of a novel member of small G protein superfamily and its expression in colon cancer. (PubMed id 12918107)1, 9 Yan W....Wang L. (World J. Gastroenterol. 2003)
    8. Nucleotide-dependent binding of the GTPase domain of the signal recognition particle receptor beta-subunit to the alpha-subunit. (PubMed id 10859309)3, 9 Legate K.R....Andrews D.W. (J. Biol. Chem. 2000)
    9. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 58477 HGNC: 24085 AceView: SRPRB Ensembl:ENSG00000144867 euGenes: HUgn58477
    ECgene: SRPRB Kegg: 58477 H-InvDB: SRPRB

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SRPRB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SRPRB gene:
    Search GeneIP for patents involving SRPRB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SRPRB   OriGene RNAi products in human, mouse, rat for SRPRB  
     OriGene qPCR primer pairs and template standards for SRPRB   OriGene Protein Over-expression Lysate for SRPRB  
     OriGene MassSpec something-or-other for SRPRB   OriGene clones in human, mouse for SRPRB  
     OriGene qSTAR qPCR primer pairs in human, mouse for SRPRB   OriGene Purified Protein for SRPRB  
     OriGene ORF clones in mouse, rat for SRPRB   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SRPRB   OriGene Custom Protein Services for SRPRB  

     
     
     Block miRNA regulation of human, mouse, rat SRPRB using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SRPRB
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SRPRB Predesigned siRNA for gene silencing in human, mouse, rat SRPRB
     QuantiFast Probe-based Assays in human, mouse, rat SRPRB QuantiTect SYBR Green Assays in human, mouse, rat SRPRB
     Custom PCR Arrays for SRPRB Search Chromatin IP Primers for SRPRB
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SRPRB  GeneGlobe Interaction Network for SRPRB
     Regulatory tfbs in SRPRB promoter
     GenScript Custom Purified and Recombinant Proteins Services for SRPRB GenScript cDNA clones with any tag delivered in your preferred vector for SRPRB
     GenScript Custom Assay Services for SRPRB GenScript Custom overexpressing Cell Line Services for SRPRB
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SRPRB
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for SRPRB
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SRPRB antibodies
     SRPRB proteins
     SRPRB lysates
     Search for Antibodies for SRPRB at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SRPRB
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SRPRB
     Antibodies for SRPRB
     ELISAs for SRPRB
     CLIAs for SRPRB



     Browse ESI BIO Cell Lines and PureStem Progenitors for SRPRB
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRPRB
     SwitchGear 3'UTR luciferase reporter plasmids for SRPRB
     SwitchGear Promoter luciferase reporter plasmids for SRPRB
     Search ThermoFisher Antibodies for SRPRB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRPRB
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SRPRB
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SRPRB
     LSBio Antibodies in human, mouse, rat for SRPRB
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for SRPRB
      Search eBioscience for proteins for SRPRB
      Search eBioscience for elisas for SRPRB
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SRPRB gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4