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Aliases for SRPRA Gene

Aliases for SRPRA Gene

  • SRP Receptor Alpha Subunit 2 3 5
  • Signal Recognition Particle Receptor (Docking Protein) 2 3
  • Docking Protein Alpha 3 4
  • DP-Alpha 3 4
  • SR-Alpha 3 4
  • SRPR 3 4
  • SRP-Alpha 3
  • Sralpha 3
  • DP 3

External Ids for SRPRA Gene

Previous HGNC Symbols for SRPRA Gene

  • SRPR

Summaries for SRPRA Gene

Entrez Gene Summary for SRPRA Gene

  • The gene encodes a subunit of the endoplasmic reticulum signal recognition particle receptor that, in conjunction with the signal recognition particle, is involved in the targeting and translocation of signal sequence tagged secretory and membrane proteins across the endoplasmic reticulum. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

GeneCards Summary for SRPRA Gene

SRPRA (SRP Receptor Alpha Subunit) is a Protein Coding gene. Among its related pathways are Protein export and Gene Expression.

UniProtKB/Swiss-Prot for SRPRA Gene

  • Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRPRA Gene

Genomics for SRPRA Gene

Regulatory Elements for SRPRA Gene

Enhancers for SRPRA Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SRPRA on UCSC Golden Path with GeneCards custom track

Promoters for SRPRA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SRPRA on UCSC Golden Path with GeneCards custom track

Genomic Location for SRPRA Gene

Chromosome:
11
Start:
126,262,919 bp from pter
End:
126,269,144 bp from pter
Size:
6,226 bases
Orientation:
Minus strand

Genomic View for SRPRA Gene

Genes around SRPRA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRPRA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRPRA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRPRA Gene

Proteins for SRPRA Gene

  • Protein details for SRPRA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08240-SRPRA_HUMAN
    Recommended name:
    Signal recognition particle receptor subunit alpha
    Protein Accession:
    P08240
    Secondary Accessions:
    • A6NIB3
    • B2R5Z8
    • B4E0H3
    • E9PJS4
    • Q9BVJ4

    Protein attributes for SRPRA Gene

    Size:
    638 amino acids
    Molecular mass:
    69811 Da
    Quaternary structure:
    • Heterodimer with SRPRB.

    Three dimensional structures from OCA and Proteopedia for SRPRA Gene

    Alternative splice isoforms for SRPRA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRPRA Gene

Proteomics data for SRPRA Gene at MOPED

Post-translational modifications for SRPRA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SRPRA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SRPRA Gene

Domains & Families for SRPRA Gene

Suggested Antigen Peptide Sequences for SRPRA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P08240

UniProtKB/Swiss-Prot:

SRPRA_HUMAN :
  • Belongs to the GTP-binding SRP family.
Family:
  • Belongs to the GTP-binding SRP family.
genes like me logo Genes that share domains with SRPRA: view

No data available for Gene Families for SRPRA Gene

Function for SRPRA Gene

Molecular function for SRPRA Gene

UniProtKB/Swiss-Prot Function:
Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system.
genes like me logo Genes that share phenotypes with SRPRA: view

Animal Model Products

miRNA for SRPRA Gene

miRTarBase miRNAs that target SRPRA

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SRPRA Gene

Localization for SRPRA Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRPRA Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Thought to be anchored in the membrane through an interaction with SR-beta, which contains a bona fide transmembrane domain.

Gene Ontology (GO) - Cellular Components for SRPRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005785 signal recognition particle receptor complex IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with SRPRA: view

No data available for Subcellular locations from COMPARTMENTS for SRPRA Gene

Pathways & Interactions for SRPRA Gene

genes like me logo Genes that share pathways with SRPRA: view

Pathways by source for SRPRA Gene

Gene Ontology (GO) - Biological Process for SRPRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006613 cotranslational protein targeting to membrane TAS 2827661
GO:0006810 transport IEA --
GO:0030968 endoplasmic reticulum unfolded protein response TAS --
GO:0036498 IRE1-mediated unfolded protein response TAS --
genes like me logo Genes that share ontologies with SRPRA: view

No data available for SIGNOR curated interactions for SRPRA Gene

Drugs & Compounds for SRPRA Gene

(1) Drugs for SRPRA Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(1) Additional Compounds for SRPRA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SRPRA: view

Transcripts for SRPRA Gene

Alternative Splicing Database (ASD) splice patterns (SP) for SRPRA Gene

No ASD Table

Relevant External Links for SRPRA Gene

GeneLoc Exon Structure for
SRPRA
ECgene alternative splicing isoforms for
SRPRA

Expression for SRPRA Gene

No Expression Related Data Available

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SRPRA Gene

Orthologs for SRPRA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SRPRA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SRPR 35
  • 90.39 (n)
  • 96.55 (a)
SRPR 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRPR 35
  • 91.07 (n)
  • 94.2 (a)
SRPR 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srpr 35
  • 91.72 (n)
  • 97.48 (a)
Srpr 16
Srpr 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SRPR 35
  • 99.06 (n)
  • 99.06 (a)
SRPR 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Srpr 35
  • 92.14 (n)
  • 97.96 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 91 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
chicken
(Gallus gallus)
Aves SRPR 35
  • 74.87 (n)
  • 80.13 (a)
SRPR 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRPR 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia srpr 35
  • 69.6 (n)
  • 72.96 (a)
Str.11928 35
zebrafish
(Danio rerio)
Actinopterygii idibd1064 35
srpr 35
  • 67.57 (n)
  • 69.79 (a)
srpr 36
  • 67 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010894 35
  • 60.47 (n)
  • 61.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta Gtp-bp 35
  • 58.8 (n)
  • 55.48 (a)
Gtp-bp 36
  • 53 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_F38A1.8 35
  • 53.84 (n)
  • 52.24 (a)
F38A1.8 36
  • 49 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SRP101 36
  • 32 (a)
OneToOne
SRP101 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G30600 35
  • 52.74 (n)
  • 46.31 (a)
soybean
(Glycine max)
eudicotyledons Gma.17407 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6715 35
barley
(Hordeum vulgare)
Liliopsida Hv.296 35
rice
(Oryza sativa)
Liliopsida Os.4838 35
Os08g0480100 35
  • 53.49 (n)
  • 47.36 (a)
corn
(Zea mays)
Liliopsida Zm.3583 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1732 35
bread mold
(Neurospora crassa)
Ascomycetes NCU11187 35
  • 48.53 (n)
  • 37.91 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC3B9.03 35
  • 48.87 (n)
  • 40.23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 60 (a)
OneToOne
Species with no ortholog for SRPRA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRPRA Gene

ENSEMBL:
Gene Tree for SRPRA (if available)
TreeFam:
Gene Tree for SRPRA (if available)

Paralogs for SRPRA Gene

No data available for Paralogs for SRPRA Gene

Variants for SRPRA Gene

Sequence variations from dbSNP and Humsavar for SRPRA Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs529328 -- 126,263,746(-) GCCAT(C/T)TGCAA utr-variant-3-prime
rs638766 -- 126,264,803(+) TGTTA(C/T)CCAAA intron-variant
rs1049665 -- 126,263,737(-) AAGGA(A/G)GGCCT utr-variant-3-prime
rs1049666 -- 126,263,681(-) CCCCC(C/T)TCCTA utr-variant-3-prime
rs2230546 -- 126,264,032(-) CTGCT(A/G)TTTCT reference, missense

Variation tolerance for SRPRA Gene

Residual Variation Intolerance Score: 8.28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRPRA Gene

HapMap Linkage Disequilibrium report
SRPRA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SRPRA Gene

Disorders for SRPRA Gene

Relevant External Links for SRPRA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRPRA

No disorders were found for SRPRA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRPRA Gene

Publications for SRPRA Gene

  1. Complete cDNA sequence coding for human docking protein. (PMID: 3340536) Hortsch M. … Meyer D.I. (Nucleic Acids Res. 1988) 2 3 4 67
  2. PCR-assisted localization of the human SRPR gene. (PMID: 1312991) Janin N. … Lipinski M. (Hum. Genet. 1992) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for SRPRA Gene

Sources for SRPRA Gene

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