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Aliases for SRPRA Gene

Aliases for SRPRA Gene

  • SRP Receptor Alpha Subunit 2 3 5
  • Signal Recognition Particle Receptor (Docking Protein) 2 3
  • Docking Protein Alpha 3 4
  • DP-Alpha 3 4
  • SR-Alpha 3 4
  • SRPR 3 4
  • Signal Recognition Particle Receptor Subunit Alpha 3
  • SRP-Alpha 3
  • Sralpha 3
  • DP 3

External Ids for SRPRA Gene

Previous HGNC Symbols for SRPRA Gene

  • SRPR

Summaries for SRPRA Gene

Entrez Gene Summary for SRPRA Gene

  • The gene encodes a subunit of the endoplasmic reticulum signal recognition particle receptor that, in conjunction with the signal recognition particle, is involved in the targeting and translocation of signal sequence tagged secretory and membrane proteins across the endoplasmic reticulum. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

GeneCards Summary for SRPRA Gene

SRPRA (SRP Receptor Alpha Subunit) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Unfolded Protein Response (UPR).

UniProtKB/Swiss-Prot for SRPRA Gene

  • Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system.

Additional gene information for SRPRA Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRPRA Gene

Genomics for SRPRA Gene

Regulatory Elements for SRPRA Gene

Enhancers for SRPRA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H126317 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -49.6 -49643 3.2 PKNOX1 KLF1 ATF1 MAX RAD21 GLIS2 POLR2A EED ATF7 RUNX3 FOXRED1 ST3GAL4 TIRAP SRPRA DCPS FAM118B HYLS1 HP11014 PIR55528
GH11H126480 1.4 Ensembl ENCODE dbSUPER 9.5 -211.8 -211805 1.1 TBP HDGF ATF1 RB1 ARID4B ZBTB40 ZNF2 RAD21 ELK1 ZNF143 HP11014 ENSG00000254905 TIRAP DCPS KIRREL3 FOXRED1 SRPRA KIRREL3-AS1 ENSG00000278215
GH11H126060 1.3 Ensembl ENCODE 10.1 +206.8 206774 3.5 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 TIRAP STT3A TMEM218 FEZ1 SRPRA CDON PIR48177
GH11H126210 1.1 ENCODE 10.8 +57.1 57117 3 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143 FOS SP3 FOXRED1 FAM118B ENSG00000254694 STT3A SRPRA CDON RPUSD4 RNU4-86P
GH11H126203 0.7 ENCODE 10.3 +65.9 65864 0.2 FOXA2 MAX REST RAD21 FOXA1 NR2F2 GABPA YY1 JUND HNF4G SRPRA FOXRED1 ENSG00000254790 ENSG00000254694 ENSG00000254771
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SRPRA on UCSC Golden Path with GeneCards custom track

Promoters for SRPRA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000046623 344 1601 PKNOX1 ARID4B SIN3A DMAP1 YY1 FOS SP3 SP5 ZHX2 MXD4

Genomic Locations for SRPRA Gene

Genomic Locations for SRPRA Gene
chr11:126,262,919-126,269,144
(GRCh38/hg38)
Size:
6,226 bases
Orientation:
Minus strand
chr11:126,132,814-126,139,039
(GRCh37/hg19)

Genomic View for SRPRA Gene

Genes around SRPRA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRPRA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRPRA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRPRA Gene

Proteins for SRPRA Gene

  • Protein details for SRPRA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08240-SRPRA_HUMAN
    Recommended name:
    Signal recognition particle receptor subunit alpha
    Protein Accession:
    P08240
    Secondary Accessions:
    • A6NIB3
    • B2R5Z8
    • B4E0H3
    • E9PJS4
    • Q9BVJ4

    Protein attributes for SRPRA Gene

    Size:
    638 amino acids
    Molecular mass:
    69811 Da
    Quaternary structure:
    • Heterodimer with SRPRB.

    Three dimensional structures from OCA and Proteopedia for SRPRA Gene

    Alternative splice isoforms for SRPRA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRPRA Gene

Post-translational modifications for SRPRA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SRPRA Gene

No data available for DME Specific Peptides for SRPRA Gene

Domains & Families for SRPRA Gene

Gene Families for SRPRA Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for SRPRA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P08240

UniProtKB/Swiss-Prot:

SRPRA_HUMAN :
  • Belongs to the GTP-binding SRP family.
Family:
  • Belongs to the GTP-binding SRP family.
genes like me logo Genes that share domains with SRPRA: view

Function for SRPRA Gene

Molecular function for SRPRA Gene

UniProtKB/Swiss-Prot Function:
Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system.

Phenotypes From GWAS Catalog for SRPRA Gene

Gene Ontology (GO) - Molecular Function for SRPRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0003924 GTPase activity IEA --
GO:0005047 signal recognition particle binding IEA,TAS --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with SRPRA: view
genes like me logo Genes that share phenotypes with SRPRA: view

Animal Model Products

miRNA for SRPRA Gene

miRTarBase miRNAs that target SRPRA

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SRPRA Gene

Localization for SRPRA Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRPRA Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Thought to be anchored in the membrane through an interaction with SR-beta, which contains a bona fide transmembrane domain.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRPRA gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
nucleus 2
cytosol 2
plasma membrane 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SRPRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum TAS 2827661
GO:0005785 signal recognition particle receptor complex TAS,IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IDA 22375059
GO:0016021 integral component of membrane TAS 2827661
genes like me logo Genes that share ontologies with SRPRA: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SRPRA Gene

Pathways & Interactions for SRPRA Gene

genes like me logo Genes that share pathways with SRPRA: view

Pathways by source for SRPRA Gene

Gene Ontology (GO) - Biological Process for SRPRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006613 cotranslational protein targeting to membrane TAS 2827661
GO:0006614 SRP-dependent cotranslational protein targeting to membrane IEA --
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IEA --
GO:0036498 IRE1-mediated unfolded protein response TAS --
genes like me logo Genes that share ontologies with SRPRA: view

No data available for SIGNOR curated interactions for SRPRA Gene

Drugs & Compounds for SRPRA Gene

(1) Drugs for SRPRA Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(1) Additional Compounds for SRPRA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SRPRA: view

Transcripts for SRPRA Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRPRA Gene

No ASD Table

Relevant External Links for SRPRA Gene

GeneLoc Exon Structure for
SRPRA
ECgene alternative splicing isoforms for
SRPRA

Expression for SRPRA Gene

NURSA nuclear receptor signaling pathways regulating expression of SRPRA Gene:

SRPRA

Evidence on tissue expression from TISSUES for SRPRA Gene

  • Nervous system(4.8)
  • Lung(4.7)
  • Liver(4.5)
  • Muscle(4.5)
  • Skin(3.3)
  • Pancreas(3.2)
  • Intestine(3.1)
  • Kidney(3.1)
  • Spleen(2)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRPRA Gene

Orthologs for SRPRA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SRPRA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRPR 34 33
  • 99.06 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Srpr 33
  • 92.14 (n)
mouse
(Mus musculus)
Mammalia Srpr 16 34 33
  • 91.72 (n)
dog
(Canis familiaris)
Mammalia SRPR 34 33
  • 91.07 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 91 (a)
OneToMany
-- 34
  • 91 (a)
OneToMany
cow
(Bos Taurus)
Mammalia SRPR 34 33
  • 90.39 (n)
OneToOne
chicken
(Gallus gallus)
Aves SRPR 33 34
  • 74.87 (n)
lizard
(Anolis carolinensis)
Reptilia SRPR 34
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia srpr 33
  • 69.6 (n)
Str.11928 33
zebrafish
(Danio rerio)
Actinopterygii srpr 33 34
  • 67.57 (n)
idibd1064 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010894 33
  • 60.47 (n)
fruit fly
(Drosophila melanogaster)
Insecta Gtp-bp 33 34
  • 58.8 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_F38A1.8 33
  • 53.84 (n)
F38A1.8 34
  • 49 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SRP101 34 36
  • 32 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G30600 33
  • 52.74 (n)
soybean
(Glycine max)
eudicotyledons Gma.17407 33
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6715 33
rice
(Oryza sativa)
Liliopsida Os08g0480100 33
  • 53.49 (n)
Os.4838 33
barley
(Hordeum vulgare)
Liliopsida Hv.296 33
corn
(Zea mays)
Liliopsida Zm.3583 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 60 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC3B9.03 33
  • 48.87 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU11187 33
  • 48.53 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1732 33
Species where no ortholog for SRPRA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRPRA Gene

ENSEMBL:
Gene Tree for SRPRA (if available)
TreeFam:
Gene Tree for SRPRA (if available)

Paralogs for SRPRA Gene

No data available for Paralogs for SRPRA Gene

Variants for SRPRA Gene

Sequence variations from dbSNP and Humsavar for SRPRA Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs372318280 Likely benign 126,269,231(+) CGCAC(C/G)GCATG nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs149883459 Uncertain significance 126,269,216(+) TTCGG(A/C/G/T)GGGTT nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs368307265 Uncertain significance 126,269,176(+) AGTGC(A/G)GCTTT nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs375454069 Uncertain significance 126,269,241(+) GGGCC(C/G)GGGCC nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs552937899 Uncertain significance 126,269,044(+) GAGAG(C/G)TCACG nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SRPRA Gene

Variant ID Type Subtype PubMed ID
nsv556530 CNV loss 21841781
nsv556529 CNV loss 21841781

Variation tolerance for SRPRA Gene

Residual Variation Intolerance Score: 8.28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRPRA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRPRA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRPRA Gene

Disorders for SRPRA Gene

Relevant External Links for SRPRA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRPRA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRPRA

No disorders were found for SRPRA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRPRA Gene

Publications for SRPRA Gene

  1. Complete cDNA sequence coding for human docking protein. (PMID: 3340536) Hortsch M … Meyer DI (Nucleic acids research 1988) 2 3 4 60
  2. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J … Comb MJ (Nature biotechnology 2005) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. PCR-assisted localization of the human SRPR gene. (PMID: 1312991) Janin N … Lipinski M (Human genetics 1992) 2 3 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for SRPRA Gene

Sources for SRPRA Gene

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