Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SRPR Gene

protein-coding   GIFtS: 59
GCID: GC11M126132

Signal Recognition Particle Receptor (Docking Protein)

(Previous name: signal recognition particle receptor ('docking protein'))
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Signal Recognition Particle Receptor (Docking Protein)1 2     DP2
Docking Protein Alpha2 3     SRP-alpha2
DP-alpha2 3     Sralpha2
SR-alpha2 3     Signal Recognition Particle Receptor Subunit Alpha2
Signal Recognition Particle Receptor ('Docking Protein')1     

External Ids:    HGNC: 113071   Entrez Gene: 67342   Ensembl: ENSG000001829347   OMIM: 1821805   UniProtKB: P082403   

Export aliases for SRPR gene to outside databases

Previous GC identifers: GC11U990126 GC11M127645 GC11M126166 GC11M125670 GC11M125638 GC11M122075


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SRPR Gene:
The gene encodes a subunit of the endoplasmic reticulum signal recognition particle receptor that, in conjunction
with the signal recognition particle, is involved in the targeting and translocation of signal sequence tagged
secretory and membrane proteins across the endoplasmic reticulum. Alternative splicing results in multiple
transcript variants. (provided by RefSeq, Apr 2010)

GeneCards Summary for SRPR Gene:
SRPR (signal recognition particle receptor (docking protein)) is a protein-coding gene. GO annotations related to this gene include signal recognition particle binding and GTP binding.

UniProtKB/Swiss-Prot: SRPR_HUMAN, P08240
Function: Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal
recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum
membrane system




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the SRPR gene promoter:
         HFH-3   HOXA3   Brachyury   HSF1 (long)   NRSF form 2   c-Ets-1   FOXI1   IRF-7A   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSRPR promoter sequence
   Search Chromatin IP Primers for SRPR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SRPR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.2   Ensembl cytogenetic band:  11q24.2   HGNC cytogenetic band: 11q24-q25

SRPR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRPR gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M126132:  view genomic region     (about GC identifiers)

Start:
126,132,814 bp from pter      End:
126,139,039 bp from pter
Size:
6,226 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SRPR_HUMAN, P08240 (See protein sequence)
Recommended Name: Signal recognition particle receptor subunit alpha  
Size: 638 amino acids; 69811 Da
Subunit: Heterodimer with SRPRB
2 PDB 3D structures from and Proteopedia for SRPR:
2FH5 (3D)        2GO5 (3D)    
Secondary accessions: A6NIB3 B2R5Z8 B4E0H3 E9PJS4 Q9BVJ4
Alternative splicing: 2 isoforms:  P08240-1   P08240-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SRPR: NX_P08240

Explore proteomics data for SRPR at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys492
  • Modification sites at PhosphoSitePlus

  • See SRPR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001171313.1  NP_003130.2  

    ENSEMBL proteins: 
     ENSP00000328023   ENSP00000435508  
    Reactome Protein details: P08240

    SRPR Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SRPR
    OriGene Protein Over-expression Lysate for SRPR
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SRPR
    GenScript Custom Purified and Recombinant Proteins Services for SRPR
    Novus Biologicals SRPR Protein
    Novus Biologicals SRPR Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SRPR

     
    Search eBioscience for Proteins for SRPR 

     
    antibodies-online proteins for SRPR (4 products) 

     
    antibodies-online peptides for SRPR

    SRPR Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SRPR
    Novus Biologicals SRPR Antibodies
    Search for Antibodies for SRPR at Abcam
    Cloud-Clone Corp. Antibodies for SRPR
    ThermoFisher Antibody for SRPR
    antibodies-online antibodies for SRPR (25 products) 

    SRPR Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SRPR
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SRPR
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SRPR
    Cloud-Clone Corp. CLIAs for SRPR
    Search eBioscience for ELISAs for SRPR 
    antibodies-online kits for SRPR (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    Selected InterPro protein domains (see all 6):
     IPR007222 Sig_recog_particle_rcpt_asu_N
     IPR013822 Signal_recog_particl_SRP54_hlx
     IPR027417 P-loop_NTPase
     IPR003593 AAA+_ATPase
     IPR000897 SRP54_GTPase_dom

    Graphical View of Domain Structure for InterPro Entry P08240

    ProtoNet protein and cluster: P08240

    1 Blocks protein domain: IPB000897 GTP-binding signal recognition particle (SRP54) G-domain

    UniProtKB/Swiss-Prot: SRPR_HUMAN, P08240
    Similarity: Belongs to the GTP-binding SRP family


    Find genes that share domains with SRPR           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRPR_HUMAN, P08240
    Function: Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal
    recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum
    membrane system

         Genatlas biochemistry entry for SRPR:
    signal recognition particle receptor,'docking protein'

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0003924GTPase activity IEA--
    GO:0005047signal recognition particle binding IEA--
    GO:0005525GTP binding IEA--
    GO:0017111nucleoside-triphosphatase activity ----
         
    Find genes that share ontologies with SRPR           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SRPR

    miRNA
    Products:
        
    miRTarBase miRNAs that target SRPR:
    hsa-mir-26b-5p (MIRT050050), hsa-mir-92a-3p (MIRT049696), hsa-mir-30c-1-3p (MIRT038541), hsa-mir-484 (MIRT042184), hsa-mir-25-3p (MIRT050241), hsa-mir-421 (MIRT039433), hsa-mir-30b-5p (MIRT023411), hsa-mir-16-5p (MIRT001409), hsa-mir-423-3p (MIRT042488)

    Block miRNA regulation of human, mouse, rat SRPR using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SRPR (see all 36):
    hsa-miR-330-5p hsa-miR-15a hsa-miR-25 hsa-miR-503 hsa-miR-759 hsa-miR-449a hsa-miR-1184 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidSRPR 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SRPR
    Predesigned siRNA for gene silencing in human, mouse, rat SRPR

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SRPR

    Clone
    Products:
         
    OriGene clones in human, mouse for SRPR (see all 11)
    OriGene ORF clones in mouse, rat for SRPR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SRPR (NM_003139)
    Sino Biological Human cDNA Clone for SRPR
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRPR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRPR

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SRPR
    Browse ESI BIO Cell Lines and PureStem Progenitors for SRPR 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRPR

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12210) for SRPR 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SRPR_HUMAN, P08240: Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Thought to be anchored in
    the membrane through an interaction with SR-beta, which contains a bona fide transmembrane domain
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    cytosol2
    nucleus2
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum TAS2827661
    GO:0005785signal recognition particle receptor complex IEA--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016020membrane IDA--
    GO:0016021integral component of membrane TAS2827661

    Find genes that share ontologies with SRPR           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SRPR About    
    See pathways by source

    SuperPathContained pathways About
    1Unfolded Protein Response
    Unfolded Protein Response0.61
    Activation of Chaperone Genes by XBP1(S)0.59
    Activation of Chaperones by IRE1alpha0.61
    2Influenza Viral RNA Transcription and Replication
    SRP-dependent cotranslational protein targeting to membrane0.83
    Translation0.82
    3Gene Expression
    Gene Expression0.40
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    5Protein export
    Protein export


    Find genes that share SuperPaths with SRPR           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for SRPR
        XBP1(S) activates chaperone genes
    SRP-dependent cotranslational protein targeting to membrane


    1 Kegg Pathway  (Kegg details for SRPR):
        Protein export

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SRPR
    Interactions:

        GeneGlobe Interaction Network for SRPR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SRPR (P082402, 3 ENSP000003280234) via UniProtKB, MINT, STRING, and/or I2D (see all 139)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206353Q154773I2D: score=1 
    ENSG00000223493Q154773I2D: score=1 
    ENSG00000225737Q154773I2D: score=1 
    ENSG00000228896Q154773I2D: score=1 
    ENSG00000232616Q154773I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0006412translation TAS--
    GO:0006613cotranslational protein targeting to membrane TAS2827661
    GO:0006614SRP-dependent cotranslational protein targeting to membrane TAS--
    GO:0006810transport ----

    Find genes that share ontologies with SRPR           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SRPR

    1 HMDB Compound for SRPR    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    1 Novoseek inferred chemical compound relationship for SRPR gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 67.9 15 1315314 (3), 7803856 (3), 9182758 (2), 11566135 (1)



    Find genes that share compounds with SRPR           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SRPR gene (2 alternative transcripts): 
    NM_001177842.1  NM_003139.3  

    Unigene Cluster for SRPR:

    Signal recognition particle receptor (docking protein)
    Hs.368376  [show with all ESTs]
    Unigene Representative Sequence: NM_003139
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000332118(uc001qdh.3 uc010sbm.2) ENST00000532259 ENST00000532268
    ENST00000531104 ENST00000527817 ENST00000528744 ENST00000530680
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SRPR using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SRPR (see all 36):
    hsa-miR-330-5p hsa-miR-15a hsa-miR-25 hsa-miR-503 hsa-miR-759 hsa-miR-449a hsa-miR-1184 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidSRPR 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SRPR
    Predesigned siRNA for gene silencing in human, mouse, rat SRPR
    Clone
    Products:
         
    OriGene clones in human, mouse for SRPR (see all 11)
    OriGene ORF clones in mouse, rat for SRPR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SRPR (NM_003139)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRPR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRPR
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SRPR
    OriGene qSTAR qPCR primer pairs in human, mouse for SRPR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SRPR
      QuantiTect SYBR Green Assays in human, mouse, rat SRPR
      QuantiFast Probe-based Assays in human, mouse, rat SRPR
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12210) for SRPR 

    Additional mRNA sequence: 

    AK130382.1 AK303379.1 AK312377.1 BC001162.1 BC008077.2 BC009110.1 BC013583.1 CR457025.1 
    X06272.1 

    19 DOTS entries:

    DT.100885980  DT.100798722  DT.448082  DT.95209126  DT.97855045  DT.95331436  DT.95075047  DT.120713201 
    DT.119813  DT.100885981  DT.95347978  DT.101962648  DT.92451741  DT.95376234  DT.95376240  DT.100030608 
    DT.100885979  DT.92451732  DT.100878456 

    Selected AceView cDNA sequences (see all 638):

    CA432438 AI951469 BI836879 BF791781 BQ024111 BQ447273 N71657 BU630251 
    AL713396 N26578 CN481121 CA454378 AA600168 AW139284 BE466453 AW338456 
    AI565134 BC001162 AI708406 N52650 AA909797 BP355249 AI094337 BF222974 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SRPR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCCCCTTCC
    SRPR Expression
    About this image

    SRPR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SRPR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.368376
        Custom PCR Arrays for SRPR
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SRPR
    OriGene qSTAR qPCR primer pairs in human, mouse for SRPR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SRPR
    QuantiTect SYBR Green Assays in human, mouse, rat SRPR
    QuantiFast Probe-based Assays in human, mouse, rat SRPR
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRPR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SRPR gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srpr1 , 5 signal recognition particle receptor ('docking protein')1, 5 91.72(n)1
    97.48(a)1
      9 (20.06 cM)5
    673981  NM_026130.11  NP_080406.11 
     352001755 
    chicken
    (Gallus gallus)
    Aves SRPR1 signal recognition particle receptor (docking protein) 74.87(n)
    80.13(a)
      419713  NM_001039277.1  NP_001034366.1 
    lizard
    (Anolis carolinensis)
    Reptilia SRPR6
    signal recognition particle receptor (docking prot...
    77(a)
    1 ↔ 1
    GL343322.1(1079321-1096052)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.119282 Transcribed sequence with moderate similarity to protein more 78.82(n)    137715251 
    zebrafish
    (Danio rerio)
    Actinopterygii idibd10642 idibd1064 76.8(n)   338111  57058352 
    fruit fly
    (Drosophila melanogaster)
    Insecta Gtp-bp1 GTP-binding protein 58.8(n)
    55.48(a)
      47251  NM_080148.3  NP_524887.2 
    worm
    (Caenorhabditis elegans)
    Secernentea W09G12.53
    CELE_F38A1.81
    GTP-binding protein3
    CELE_F38A1.81
    80(a)
    (best of 2)3
    53.84(n)1
    52.24(a)1
      IV(1233538-1234740)3
    1854381  NM_171254.41  NP_741303.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SRP101(YDR292C)4 Signal recognition particle (SRP) receptor alpha subunit; more   --   4(1045011-1043146) 851886  NP_010578.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G306001 AT4G30600 52.74(n)
    46.31(a)
      829183  NM_119206.4  NP_194789.1 
    rice
    (Oryza sativa)
    Liliopsida Os.48382 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 74.32(n)    AK101591.1 


    ENSEMBL Gene Tree for SRPR (if available)
    TreeFam Gene Tree for SRPR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SRPR (see all 167)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1389844651,2
    --126133401(+) CAAGAA/CCTGGC 2 -- ut310--------
    rs1416010671,2
    C--126133413(+) CTGGCC/TCTGGA 2 -- ut310--------
    rs1918780841,2
    --126133423(+) AAGAGG/TCTCTT 2 -- ut310--------
    rs116022941,2
    C,F,H--126133561(+) AAGGGG/AGTGCC 2 -- ut315Minor allele frequency- A:0.01NS EA NA 382
    rs10496661,2
    C,F,A,H--126133576(-) CCCCCT/CTCCTA 2 -- ut31 trp318Minor allele frequency- C:0.13NS EA NA CSA WA 2342
    rs31898501,2
    C,F,A,H--126133587(-) CCAGCG/TGGCCT 2 -- ut3118Minor allele frequency- T:0.15MN NS EA NA CSA WA 2506
    rs559444211,2
    C--126133588(+) GGCCCG/ACTGGG 2 -- ut312Minor allele frequency- A:0.06WA 120
    rs10496651,2
    C,F,A,H--126133632(-) AAGGAA/GGGCCT 2 -- ut3125Minor allele frequency- G:0.14EA MN NS NA CSA WA 4174
    rs5293281,2
    C,F,A,H--126133641(-) GCCATC/TTGCAA 2 -- ut3123Minor allele frequency- T:0.14MN NS EA NA WA 2612
    rs22423901,2
    C,F,H--126133670(+) GTGGGA/C/GTTGGA 4 -- ut317EA NA CSA 1359

    HapMap Linkage Disequilibrium report for SRPR (126132814 - 126139039 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SRPR: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SRPR
    DNA2.0 Custom Variant and Variant Library Synthesis for SRPR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 182180    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for SRPR:
    Diphtheria

    Find genes that share disorders with SRPR           About GenesLikeMe


    Export disorders for SRPR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SRPR gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with SRPR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete cDNA sequence coding for human docking protein. (PubMed id 3340536)1, 2, 3 Hortsch M.... Meyer D.I. (Nucleic Acids Res. 1988)
    2. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. PCR-assisted localization of the human SRPR gene. (PubMed id 1312991)1, 3 Janin N....Lipinski M. (Hum. Genet. 1992)
    5. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    6. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    7. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
    8. SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation. (PubMed id 23246001)1 Xu Y....Ye Y. (Cell Rep 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 6734 HGNC: 11307 AceView: SRPR Ensembl:ENSG00000182934 euGenes: HUgn6734
    ECgene: SRPR Kegg: 6734 H-InvDB: SRPR

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SRPR Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SRPR Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SRPR gene:
    Search GeneIP for patents involving SRPR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SRPR  
     OriGene qPCR primer pairs and template standards for SRPR   OriGene Protein Over-expression Lysate for SRPR  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SRPR  
     OriGene qSTAR qPCR primer pairs in human, mouse for SRPR   OriGene Purified Protein for SRPR  
     OriGene ORF clones in mouse, rat for SRPR   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SRPR   OriGene Custom Protein Services for SRPR  

     
     
     Block miRNA regulation of human, mouse, rat SRPR using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SRPR
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SRPR Predesigned siRNA for gene silencing in human, mouse, rat SRPR
     QuantiFast Probe-based Assays in human, mouse, rat SRPR QuantiTect SYBR Green Assays in human, mouse, rat SRPR
     Custom PCR Arrays for SRPR Search Chromatin IP Primers for SRPR
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SRPR  GeneGlobe Interaction Network for SRPR
     Regulatory tfbs in SRPR promoter
     GenScript Custom Purified and Recombinant Proteins Services for SRPR GenScript cDNA clones with any tag delivered in your preferred vector for SRPR
     GenScript Custom Assay Services for SRPR GenScript Custom overexpressing Cell Line Services for SRPR
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SRPR
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for SRPR
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SRPR antibodies
     SRPR proteins
     SRPR lysates
     Search for Antibodies for SRPR at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SRPR
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SRPR
     Antibodies for SRPR
     ELISAs for SRPR
     CLIAs for SRPR



     Browse ESI BIO Cell Lines and PureStem Progenitors for SRPR
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRPR
     SwitchGear 3'UTR luciferase reporter plasmids for SRPR
     SwitchGear Promoter luciferase reporter plasmids for SRPR
     ThermoFisher Antibody for SRPR
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRPR
     Browse compounds at ApexBio
     Search Addgene for plasmids for SRPR
      Search eBioscience for proteins for SRPR
      Search eBioscience for elisas for SRPR
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for SRPR
     antibodies-online antibodies for SRPR (25 products)
     antibodies-online kits for SRPR (8 products)
     antibodies-online peptides for SRPR
     antibodies-online proteins for SRPR (4 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SRPR gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4