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Aliases for SRPR Gene

Aliases for SRPR Gene

  • Signal Recognition Particle Receptor (Docking Protein) 2 3
  • Docking Protein Alpha 3 4
  • DP-Alpha 3 4
  • SR-Alpha 3 4
  • Signal Recognition Particle Receptor Subunit Alpha 3
  • SRP-Alpha 3
  • Sralpha 3
  • DP 3

External Ids for SRPR Gene

Previous GeneCards Identifiers for SRPR Gene

  • GC11U990126
  • GC11M127645
  • GC11M126166
  • GC11M125670
  • GC11M125638
  • GC11M126132
  • GC11M122075

Summaries for SRPR Gene

Entrez Gene Summary for SRPR Gene

  • The gene encodes a subunit of the endoplasmic reticulum signal recognition particle receptor that, in conjunction with the signal recognition particle, is involved in the targeting and translocation of signal sequence tagged secretory and membrane proteins across the endoplasmic reticulum. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

GeneCards Summary for SRPR Gene

SRPR (Signal Recognition Particle Receptor (Docking Protein)) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Unfolded Protein Response. GO annotations related to this gene include GTP binding and signal recognition particle binding.

UniProtKB/Swiss-Prot for SRPR Gene

  • Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRPR Gene

Genomics for SRPR Gene

Regulatory Elements for SRPR Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SRPR Gene

Start:
126,262,919 bp from pter
End:
126,269,144 bp from pter
Size:
6,226 bases
Orientation:
Minus strand

Genomic View for SRPR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SRPR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRPR Gene

Proteins for SRPR Gene

  • Protein details for SRPR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08240-SRPR_HUMAN
    Recommended name:
    Signal recognition particle receptor subunit alpha
    Protein Accession:
    P08240
    Secondary Accessions:
    • A6NIB3
    • B2R5Z8
    • B4E0H3
    • E9PJS4
    • Q9BVJ4

    Protein attributes for SRPR Gene

    Size:
    638 amino acids
    Molecular mass:
    69811 Da
    Quaternary structure:
    • Heterodimer with SRPRB.

    Three dimensional structures from OCA and Proteopedia for SRPR Gene

    Alternative splice isoforms for SRPR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRPR Gene

Proteomics data for SRPR Gene at MOPED

Post-translational modifications for SRPR Gene

  • Ubiquitination at Lys492
  • Modification sites at PhosphoSitePlus

Other Protein References for SRPR Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SRPR Gene

Domains for SRPR Gene

Suggested Antigen Peptide Sequences for SRPR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P08240

UniProtKB/Swiss-Prot:

SRPR_HUMAN :
  • P08240
Family:
  • Belongs to the GTP-binding SRP family.
genes like me logo Genes that share domains with SRPR: view

No data available for Gene Families for SRPR Gene

Function for SRPR Gene

Molecular function for SRPR Gene

GENATLAS Biochemistry: signal recognition particle receptor,docking protein
UniProtKB/Swiss-Prot Function: Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system

Gene Ontology (GO) - Molecular Function for SRPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005047 signal recognition particle binding IEA --
GO:0005525 GTP binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SRPR: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SRPR

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SRPR Gene

Localization for SRPR Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRPR Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Thought to be anchored in the membrane through an interaction with SR-beta, which contains a bona fide transmembrane domain.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRPR Gene COMPARTMENTS Subcellular localization image for SRPR gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 2
nucleus 2
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SRPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum TAS 2827661
GO:0005785 signal recognition particle receptor complex IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IDA 22375059
GO:0016021 integral component of membrane TAS 2827661
genes like me logo Genes that share ontologies with SRPR: view

Pathways for SRPR Gene

genes like me logo Genes that share pathways with SRPR: view

Pathways by source for SRPR Gene

Gene Ontology (GO) - Biological Process for SRPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006412 translation TAS --
GO:0006613 cotranslational protein targeting to membrane TAS 2827661
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
GO:0006810 transport --
genes like me logo Genes that share ontologies with SRPR: view

Compounds for SRPR Gene

(1) HMDB Compounds for SRPR Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(1) Novoseek inferred chemical compound relationships for SRPR Gene

Compound -log(P) Hits PubMed IDs
gtp 67.9 9
genes like me logo Genes that share compounds with SRPR: view

Transcripts for SRPR Gene

Unigene Clusters for SRPR Gene

Signal recognition particle receptor (docking protein):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SRPR

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRPR Gene

No ASD Table

Relevant External Links for SRPR Gene

GeneLoc Exon Structure for
SRPR
ECgene alternative splicing isoforms for
SRPR

Expression for SRPR Gene

mRNA expression in normal human tissues for SRPR Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SRPR Gene

SOURCE GeneReport for Unigene cluster for SRPR Gene Hs.368376

genes like me logo Genes that share expressions with SRPR: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SRPR Gene

Orthologs for SRPR Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SRPR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRPR 35
  • 99.06 (n)
  • 99.06 (a)
SRPR 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SRPR 35
  • 90.39 (n)
  • 96.55 (a)
SRPR 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRPR 35
  • 91.07 (n)
  • 94.2 (a)
SRPR 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srpr 35
  • 91.72 (n)
  • 97.48 (a)
Srpr 16
Srpr 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 91 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Srpr 35
  • 92.14 (n)
  • 97.96 (a)
chicken
(Gallus gallus)
Aves SRPR 35
  • 74.87 (n)
  • 80.13 (a)
SRPR 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRPR 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia srpr 35
  • 69.6 (n)
  • 72.96 (a)
Str.11928 35
zebrafish
(Danio rerio)
Actinopterygii idibd1064 35
srpr 35
  • 67.57 (n)
  • 69.79 (a)
srpr 36
  • 67 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010894 35
  • 60.47 (n)
  • 61.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta Gtp-bp 35
  • 58.8 (n)
  • 55.48 (a)
Gtp-bp 36
  • 53 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_F38A1.8 35
  • 53.84 (n)
  • 52.24 (a)
F38A1.8 36
  • 49 (a)
OneToOne
W09G12.5 37
  • 80 (a)
F38A1.8 37
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SRP101 36
  • 32 (a)
OneToOne
SRP101 38
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6715 35
soybean
(Glycine max)
eudicotyledons Gma.17407 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G30600 35
  • 52.74 (n)
  • 46.31 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.296 35
corn
(Zea mays)
Liliopsida Zm.3583 35
rice
(Oryza sativa)
Liliopsida Os.4838 35
Os08g0480100 35
  • 53.49 (n)
  • 47.36 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU11187 35
  • 48.53 (n)
  • 37.91 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC3B9.03 35
  • 48.87 (n)
  • 40.23 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1732 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 60 (a)
OneToOne
Species with no ortholog for SRPR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRPR Gene

ENSEMBL:
Gene Tree for SRPR (if available)
TreeFam:
Gene Tree for SRPR (if available)

Paralogs for SRPR Gene

No data available for Paralogs for SRPR Gene

Variants for SRPR Gene

Sequence variations from dbSNP and Humsavar for SRPR Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs499205 -- 126,264,724(-) TGTCC(G/T)CCTTT intron-variant
rs529328 -- 126,263,746(-) GCCAT(C/T)TGCAA utr-variant-3-prime
rs638766 -- 126,264,803(+) TGTTA(C/T)CCAAA intron-variant
rs1049665 -- 126,263,737(-) AAGGA(A/G)GGCCT utr-variant-3-prime
rs1049666 -- 126,263,681(-) CCCCC(C/T)TCCTA utr-variant-3-prime

Relevant External Links for SRPR Gene

HapMap Linkage Disequilibrium report
SRPR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SRPR Gene

Disorders for SRPR Gene

(1) University of Copenhagen DISEASES for SRPR Gene

genes like me logo Genes that share disorders with SRPR: view

No data available for UniProtKB/Swiss-Prot for SRPR Gene

Publications for SRPR Gene

  1. Complete cDNA sequence coding for human docking protein. (PMID: 3340536) Hortsch M. … Meyer D.I. (Nucleic Acids Res. 1988) 2 3 4
  2. PCR-assisted localization of the human SRPR gene. (PMID: 1312991) Janin N. … Lipinski M. (Hum. Genet. 1992) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3 4
  5. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3

Products for SRPR Gene

Sources for SRPR Gene

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