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Aliases for SRPK3 Gene

Aliases for SRPK3 Gene

  • SRSF Protein Kinase 3 2 3
  • Serine/Arginine-Rich Protein-Specific Kinase 3 3 4
  • Serine/Threonine-Protein Kinase 23 3 4
  • Muscle-Specific Serine Kinase 1 3 4
  • SR-Protein-Specific Kinase 3 3 4
  • Serine/Threonine Kinase 23 2 3
  • SFRS Protein Kinase 3 2 3
  • EC 2.7.11.1 4 63
  • MSSK-1 3 4
  • STK23 3 4
  • MSSK1 3 4
  • Serine Arginine Rich Protein-Specific Kinase 3 3
  • Serine/Threonine-Protein Kinase SRPK3 3

External Ids for SRPK3 Gene

Previous HGNC Symbols for SRPK3 Gene

  • STK23

Previous GeneCards Identifiers for SRPK3 Gene

  • GC0XP152699
  • GC0XP153041
  • GC0XP141703

Summaries for SRPK3 Gene

Entrez Gene Summary for SRPK3 Gene

  • This gene encodes a protein kinase similar to a protein kinase which is specific for the SR (serine/arginine-rich domain) family of splicing factors. A highly similar protein has been shown to play a role in muscle development in mice. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

GeneCards Summary for SRPK3 Gene

SRPK3 (SRSF Protein Kinase 3) is a Protein Coding gene. Among its related pathways are Sweet Taste Signaling. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is SRPK2.

UniProtKB/Swiss-Prot for SRPK3 Gene

  • Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRPK3 Gene

Genomics for SRPK3 Gene

Regulatory Elements for SRPK3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SRPK3 Gene

Start:
153,776,412 bp from pter
End:
153,785,732 bp from pter
Size:
9,321 bases
Orientation:
Plus strand

Genomic View for SRPK3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SRPK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRPK3 Gene

Proteins for SRPK3 Gene

  • Protein details for SRPK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPE1-SRPK3_HUMAN
    Recommended name:
    SRSF protein kinase 3
    Protein Accession:
    Q9UPE1
    Secondary Accessions:
    • Q13583
    • Q4F970
    • Q562F5
    • Q9UM62

    Protein attributes for SRPK3 Gene

    Size:
    567 amino acids
    Molecular mass:
    62014 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SRPK3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRPK3 Gene

Proteomics data for SRPK3 Gene at MOPED

Post-translational modifications for SRPK3 Gene

  • Ubiquitination at Lys418
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains for SRPK3 Gene

Gene Families for SRPK3 Gene

Protein Domains for SRPK3 Gene

Suggested Antigen Peptide Sequences for SRPK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UPE1

UniProtKB/Swiss-Prot:

SRPK3_HUMAN :
  • Q9UPE1
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.
genes like me logo Genes that share domains with SRPK3: view

Function for SRPK3 Gene

Molecular function for SRPK3 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function: Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development (By similarity).

Enzyme Numbers (IUBMB) for SRPK3 Gene

Gene Ontology (GO) - Molecular Function for SRPK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 23602568
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with SRPK3: view
genes like me logo Genes that share phenotypes with SRPK3: view

Animal Models for SRPK3 Gene

MGI Knock Outs for SRPK3:

Animal Model Products

CRISPR Products

miRNA for SRPK3 Gene

miRTarBase miRNAs that target SRPK3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SRPK3

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for SRPK3 Gene

Localization for SRPK3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRPK3 Gene COMPARTMENTS Subcellular localization image for SRPK3 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for SRPK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with SRPK3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SRPK3 Gene

Pathways for SRPK3 Gene

SuperPathways for SRPK3 Gene

Superpath Contained pathways
1 Sweet Taste Signaling
genes like me logo Genes that share pathways with SRPK3: view

Pathways by source for SRPK3 Gene

1 Qiagen pathway for SRPK3 Gene

Gene Ontology (GO) - Biological Process for SRPK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007519 skeletal muscle tissue development IEA --
GO:0030154 cell differentiation IEA --
GO:0060537 muscle tissue development ISS --
genes like me logo Genes that share ontologies with SRPK3: view

Compounds for SRPK3 Gene

(2) HMDB Compounds for SRPK3 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
genes like me logo Genes that share compounds with SRPK3: view

Transcripts for SRPK3 Gene

Unigene Clusters for SRPK3 Gene

SRSF protein kinase 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SRPK3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SRPK3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRPK3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b
SP1: - -
SP2: - -
SP3: - -
SP4:
SP5: -
SP6:

Relevant External Links for SRPK3 Gene

GeneLoc Exon Structure for
SRPK3
ECgene alternative splicing isoforms for
SRPK3

Expression for SRPK3 Gene

mRNA expression in normal human tissues for SRPK3 Gene

mRNA differential expression in normal tissues according to GTEx for SRPK3 Gene

This gene is overexpressed in Muscle - Skeletal (15.3), Heart - Left Ventricle (5.7), and Heart - Atrial Appendage (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SRPK3 Gene

SOURCE GeneReport for Unigene cluster for SRPK3 Gene Hs.104865

mRNA Expression by UniProt/SwissProt for SRPK3 Gene

Q9UPE1-SRPK3_HUMAN
Tissue specificity: Exclusively expressed in skeletal and heart muscle.
genes like me logo Genes that share expressions with SRPK3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SRPK3 Gene

Orthologs for SRPK3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SRPK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRPK3 35
  • 97.04 (n)
  • 96.67 (a)
SRPK3 36
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SRPK3 35
  • 90 (n)
  • 95.74 (a)
SRPK3 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRPK3 35
  • 91.48 (n)
  • 96.3 (a)
SRPK3 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srpk3 35
  • 86.79 (n)
  • 95.56 (a)
Srpk3 16
Srpk3 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRPK3 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Srpk3 35
  • 86.1 (n)
  • 94.23 (a)
chicken
(Gallus gallus)
Aves SRPK3 36
  • 36 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRPK3 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia srpk2 35
  • 70.31 (n)
  • 73.7 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11303 35
zebrafish
(Danio rerio)
Actinopterygii srpk3 35
  • 68.85 (n)
  • 74.9 (a)
srpk3 36
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta SRPK 36
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea spk-1 35
  • 53.74 (n)
  • 55.86 (a)
spk-1 36
  • 27 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SKY1 36
  • 29 (a)
OneToMany
SKY1 38
barley
(Hordeum vulgare)
Liliopsida Hv.9557 35
rice
(Oryza sativa)
Liliopsida Os.26432 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
Species with no ortholog for SRPK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRPK3 Gene

ENSEMBL:
Gene Tree for SRPK3 (if available)
TreeFam:
Gene Tree for SRPK3 (if available)

Paralogs for SRPK3 Gene

Paralogs for SRPK3 Gene

Selected SIMAP similar genes for SRPK3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SRPK3: view

Variants for SRPK3 Gene

Sequence variations from dbSNP and Humsavar for SRPK3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs762651 -- 153,779,983(+) CCCTT(A/G)TCCTT upstream-variant-2KB
rs762652 -- 153,780,357(+) GCCCA(C/T)GACAG upstream-variant-2KB
rs916001 -- 153,782,948(+) CTCTC(C/T)GCAGG intron-variant
rs1981439 -- 153,782,354(+) CCCCC(A/G)GGTAA intron-variant
rs2269366 -- 153,784,284(+) CTCTG(C/T)CTTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRPK3 Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV Gain+Loss 17666407

Relevant External Links for SRPK3 Gene

HapMap Linkage Disequilibrium report
SRPK3
Locus Specific Mutation Databases (LSDB)
SRPK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRPK3 Gene

Disorders for SRPK3 Gene

No disorders were found for SRPK3 Gene.

No data available for UniProtKB/Swiss-Prot for SRPK3 Gene

Publications for SRPK3 Gene

  1. Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2. (PMID: 16140986) Nakagawa O. … Olson E.N. (Genes Dev. 2005) 2 3
  2. Large-scale methylation analysis of human genomic DNA reveals tissue- specific differences between the methylation profiles of genes and pseudogenes. (PMID: 11063724) Grunau C. … Rosenthal A. (Hum. Mol. Genet. 2000) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Regulation of alternative splicing by SRrp86 and its interacting proteins. (PMID: 14559993) Li J. … Patton J.G. (Mol. Cell. Biol. 2003) 3
  5. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H. … Espeseth A.S. (Cell Host Microbe 2008) 3

Products for SRPK3 Gene

  • Addgene plasmids for SRPK3

Sources for SRPK3 Gene

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