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SRPK3 Gene

protein-coding   GIFtS: 56
GCID: GC0XP153041

SRSF Protein Kinase 3

(Previous names: serine/threonine kinase 23, SFRS protein kinase 3)
(Previous symbol: STK23)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SRSF Protein Kinase 31 2     MSSK-12 3
STK231 2 3     MSSK12 3
Serine/Threonine Kinase 231 2     SR-Protein-Specific Kinase 32 3
SFRS Protein Kinase 31 2     EC 2.7.11.13 8
Muscle-Specific Serine Kinase 12 3     Serine Arginine Rich Protein-Specific Kinase 32
Serine/Arginine-Rich Protein-Specific Kinase 32 3     Serine/Threonine-Protein Kinase SRPK32
Serine/Threonine-Protein Kinase 232 3     

External Ids:    HGNC: 114021   Entrez Gene: 265762   Ensembl: ENSG000001843437   UniProtKB: Q9UPE13   

Export aliases for SRPK3 gene to outside databases

Previous GC identifers: GC0XP152699 GC0XP141703


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SRPK3 Gene:
This gene encodes a protein kinase similar to a protein kinase which is specific for the SR (serine/arginine-rich
domain) family of splicing factors. A highly similar protein has been shown to play a role in muscle development
in mice. Multiple transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Dec 2009)

GeneCards Summary for SRPK3 Gene:
SRPK3 (SRSF protein kinase 3) is a protein-coding gene. Diseases associated with SRPK3 include coffin-lowry syndrome, and centronuclear myopathy. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is SRPK1.

UniProtKB/Swiss-Prot: SRPK3_HUMAN, Q9UPE1
Function: Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine
residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR
splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_011681.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the SRPK3 gene promoter:
         Egr-3   TBP   oct-B2   oct-B3   Nkx2-5   HEN1   POU2F1   COMP1   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSRPK3 promoter sequence
   Search Chromatin IP Primers for SRPK3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SRPK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

SRPK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRPK3 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP153041:  view genomic region     (about GC identifiers)

Start:
153,041,867 bp from pter      End:
153,051,187 bp from pter
Size:
9,321 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SRPK3_HUMAN, Q9UPE1 (See protein sequence)
Recommended Name: SRSF protein kinase 3  
Size: 567 amino acids; 62014 Da
Secondary accessions: Q13583 Q4F970 Q562F5 Q9UM62
Alternative splicing: 4 isoforms:  Q9UPE1-1   Q9UPE1-2   Q9UPE1-3   Q9UPE1-4   

Explore the universe of human proteins at neXtProt for SRPK3: NX_Q9UPE1

Explore proteomics data for SRPK3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys418
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for SRPK3 (Q9UPE1) (see all 11)
     YSRDEDH  DLGNACW  RDEDHIA  DYCKGGY 


    See SRPK3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001164231.1  NP_001164232.1  NP_055185.2  

    ENSEMBL proteins: 
     ENSP00000420058   ENSP00000359122   ENSP00000359126   ENSP00000359119   ENSP00000402300  
     ENSP00000359118   ENSP00000406166   ENSP00000377376  

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    Sino Biological Cell Lysate for SRPK3
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: SRSF protein kinase 3
    SRPK family

    4 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q9UPE1

    ProtoNet protein and cluster: Q9UPE1

    UniProtKB/Swiss-Prot: SRPK3_HUMAN, Q9UPE1
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    SRPK3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRPK3_HUMAN, Q9UPE1
    Function: Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine
    residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR
    splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development (By
    similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Number (IUBMB): EC 2.7.11.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
         
    SRPK3 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for SRPK3:
     Decreased focal adhesion (FA)   Increased cell death in HCT116  Increased viability with 4OH t  Synthetic lethal with Ras 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Srpk3):
     muscle 

    SRPK3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Srpk3tm1Eno for SRPK3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SRPK3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SRPK3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SRPK3

    miRNA
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    miRTarBase miRNAs that target SRPK3:
    hsa-mir-335-5p (MIRT017717)

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    3 qRT-PCR Assays for microRNAs that regulate SRPK3:
    hsa-miR-124 hsa-miR-3658 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidSRPK3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SRPK3

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    Sino Biological Human cDNA Clone for SRPK3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRPK3

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRPK3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    SRPK3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SRPK3
        Sperm Motility



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SRPK3
    Interactions:

        Search GeneGlobe Interaction Network for SRPK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SRPK3 (Q9UPE11, 3 ENSP000003591194) via UniProtKB, MINT, STRING, and/or I2D (see all 70)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SREK1Q8WXA93, ENSP000003345384I2D: score=2 STRING: ENSP00000334538
    SRPK1Q96SB41EBI-6381269,EBI-539478
    GTPBP2ENSP000003039974STRING: ENSP00000303997
    PRPF19ENSP000002275244STRING: ENSP00000227524
    CDC40ENSP000003043704STRING: ENSP00000304370
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0007519skeletal muscle tissue development IEA--
    GO:0030154cell differentiation IEA--
    GO:0060537muscle tissue development ISS--

    SRPK3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SRPK3

    2 HMDB Compounds for SRPK3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SRPK3 gene (3 alternative transcripts): 
    NM_001170760.1  NM_001170761.1  NM_014370.3  

    Unigene Cluster for SRPK3:

    SRSF protein kinase 3
    Hs.104865  [show with all ESTs]
    Unigene Representative Sequence: BC092416
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000489426(uc004fik.3) ENST00000370104 ENST00000370108 ENST00000370101(uc004fil.3 uc004fin.3)
    ENST00000430541 ENST00000370100 ENST00000458681 ENST00000393786(uc004fim.3 uc010nul.3)

    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate SRPK3:
    hsa-miR-124 hsa-miR-3658 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidSRPK3 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): SRPK3 (NM_014370)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRPK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRPK3
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SRPK3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SRPK3
      QuantiTect SYBR Green Assays in human, mouse, rat SRPK3
      QuantiFast Probe-based Assays in human, mouse, rat SRPK3

    Additional mRNA sequence: 

    AF027406.1 AK301749.1 AK314828.1 BC092416.1 BC117124.1 DQ099381.1 U82808.1 

    7 DOTS entries:

    DT.92418581  DT.210902  DT.121309426  DT.40109611  DT.100812358  DT.121309384  DT.92032992 

    Selected AceView cDNA sequences (see all 41):

    CD106669 C04409 AF027406 CF131781 NM_014370 AA640045 C05422 U82808 
    AA337930 BX282601 F35995 AA425725 BG258751 CB156737 AJ573407 F35586 
    F26902 AI333973 AI381788 AJ573084 BM807691 AI919248 BP372246 AA969001 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SRPK3 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b
    SP1:                                                                          -                             -                                 
    SP2:                                                                          -                             -                                 
    SP3:                                                                          -                             -                                 
    SP4:                                                                                                                                          
    SP5:                                                                                                        -                                 


    ECgene alternative splicing isoforms for SRPK3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SRPK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGAGTACA
    SRPK3 Expression
    About this image

    SRPK3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SRPK3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.104865

    UniProtKB/Swiss-Prot: SRPK3_HUMAN, Q9UPE1
    Tissue specificity: Exclusively expressed in skeletal and heart muscle

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SRPK3 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srpk31 , 5 serine/arginine-rich protein specific kinase 31, 5 86.79(n)1
    95.56(a)1
      X (37.41 cM)5
    565041  NM_019684.11  NP_062658.11 
     737744055 
    chicken
    (Gallus gallus)
    Aves SRPK36
    SRSF protein kinase 3
    36(a)
    1 ↔ 1
    12(11335403-11344458)
    lizard
    (Anolis carolinensis)
    Reptilia SRPK36
    SRSF protein kinase 3
    61(a)
    1 ↔ 1
    2(86499620-86553295)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia srpk21 SRSF protein kinase 2 70.31(n)
    73.7(a)
      100124819  NM_001102787.1  NP_001096257.1 
    zebrafish
    (Danio rerio)
    Actinopterygii srpk31 serine/arginine-rich protein specific kinase 3 68.85(n)
    74.9(a)
      566605  XM_689881.6  XP_694973.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta SRPK6
    SRPK
    35(a)
    1 → many
    2R(11268223-11275356)
    worm
    (Caenorhabditis elegans)
    Secernentea spk-11 spk-1 53.74(n)
    55.86(a)
      176328  NM_001025962.2  NP_001021133.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SKY1(YMR216C)4 SR protein kinase (SRPK) involved in regulating proteins more   --   13(701039-698811) 855256  NP_013943.1 
    rice
    (Oryza sativa)
    Liliopsida Os.264322 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 75.31(n)    AK070433.1 


    ENSEMBL Gene Tree for SRPK3 (if available)
    TreeFam Gene Tree for SRPK3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SRPK3 gene
    SRPK12  SRPK22  
    5 SIMAP similar genes for SRPK3 using alignment to 6 protein entries:     SRPK3_HUMAN (see all proteins):
    SRPK2    SRPK1    CDK4    DYRK1A    DYRK4

    SRPK3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SRPK3 (see all 235)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2009529221,2
    C--141703890(+) ACATGC/TGGCCT 3 -- int10--------
    rs1999837701,2
    --141703891(+) CATGCA/GGCCTC 3 -- int10--------
    rs2017023221,2
    --141704037(+) CACCCC/TGTGAA 6 P syn10--------
    rs2009236701,2
    --141704049(+) ATCGGC/TGACGT 6 G syn10--------
    rs2002215981,2
    --141704097(+) TGGGGA/CCACTT 6 G syn10--------
    rs1482652001,2
    C--141704152(+) CGCCTC/TCGGGG 3 -- int10--------
    rs1813196841,2
    C--141704153(+) GCCTCC/TGGGGC 3 -- int10--------
    rs2020581861,2
    C--141704216(+) CCGCCA/GTGGGT 3 -- int10--------
    rs2013708801,2
    --141704237(+) CCACAA/GCCTAC 3 -- int10--------
    rs559105071,2,,4
    C--141704263(+) GCAGGC/TGCAAG 6 R C mis11Minor allele frequency- T:0.00NA 4532

    HapMap Linkage Disequilibrium report for SRPK3 (153041867 - 153051187 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SRPK3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv33199CNV Gain+Loss17666407

    Locus Specific Mutation Databases (LSDB): SRPK3

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    3 diseases for SRPK3:    
    About MalaCards
    coffin-lowry syndrome    centronuclear myopathy    myopathy


    SRPK3 for disorders           About GeneDecksing


    Export disorders for SRPK3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SRPK3 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with SRPK3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2. (PubMed id 16140986)1, 3 Nakagawa O....Olson E.N. (amp 2005)
    2. Large-scale methylation analysis of human genomic DNA reveals tissue- specific differences between the methylation profiles of genes and pseudogenes. (PubMed id 11063724)1, 2 Grunau C.... Rosenthal A. (Hum. Mol. Genet. 2000)
    3. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    4. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    5. Serine-arginine protein kinases: a small protein kinase family with a large cellular presence. (PubMed id 21205200)2 Giannakouros T.... Georgatsou E. (FEBS J. 2011)
    6. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    7. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    8. Genome-scale RNAi screen for host factors required for HIV replication. (PubMed id 18976975)1 Zhou H....Espeseth A.S. (amp 2008)
    9. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (Nature 2007)
    10. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (Nature 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26576 HGNC: 11402 AceView: STK23 Ensembl:ENSG00000184343 euGenes: HUgn26576
    ECgene: SRPK3 H-InvDB: SRPK3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SRPK3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SRPK3 gene:
    Search GeneIP for patents involving SRPK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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