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SRPK2 Gene

protein-coding   GIFtS: 68
GCID: GC07M104751

SRSF Protein Kinase 2

(Previous name: SFRS protein kinase 2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
SRSF Protein Kinase 21 2     SR-Protein-Specific Kinase 22 3
SFRS Protein Kinase 21 2 3     EC 2.7.11.13 8
Serine/Arginine-Rich Splicing Factor Kinase 21 2     SFRSK22
SR Protein Kinase 21 2     Serine Kinase SRPK22
Serine/Arginine-Rich Protein-Specific Kinase 22 3     Serine/Threonine-Protein Kinase SRPK22

External Ids:    HGNC: 113061   Entrez Gene: 67332   Ensembl: ENSG000001352507   OMIM: 6029805   UniProtKB: P783623   
ORGUL members:         

Export aliases for SRPK2 gene to outside databases

Previous GC identifers: GC07M103240 GC07M104303 GC07M104317 GC07M104350 GC07M104544 GC07M099117


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SRPK2 Gene:
SRPK2 (SRSF protein kinase 2) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and 14-3-3 protein binding. An important paralog of this gene is SRPK3.

UniProtKB/Swiss-Prot: SRPK2_HUMAN, P78362
Function: Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine
residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the
phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by
up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the
suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1)
expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in
cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complex formation via the
phosphorylation of DDX23/PRP28. Can mediate hepatitis B virus (HBV) core protein phosphorylation. Plays a
negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the
core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the
formation of the viral core particles

Gene Wiki entry for SRPK2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SRPK2 gene promoter:
         HOXA9   HOXA9B   AML1a   YY1   C/EBPalpha   Meis-1b   HFH-1   FOXJ2 (long isoform)   FOXJ2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 8): SRPK2 promoter sequence
   Search Chromatin IP Primers for SRPK2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SRPK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22-q31.1   Ensembl cytogenetic band:  7q22.3   HGNC cytogenetic band: 7q22-q31.1

SRPK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRPK2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M104751:  view genomic region     (about GC identifiers)

Start:
104,751,151 bp from pter      End:
105,039,755 bp from pter
Size:
288,605 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 104,117,496-104,389,898     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SRPK2_HUMAN, P78362 (See protein sequence)
Recommended Name: SRSF protein kinase 2  
Size: 688 amino acids; 77527 Da
Cofactor: Magnesium
Subunit: Interacts with PKB/AKT1 in a phosphorylation-dependent manner. The phosphorylated form (by PKB/AKT1)
interacts with YWHAB and YWHAE. Interaction with YWHAB suppresses its cleavage by caspases and inhibits the
release of its N-terminal pro-apoptotic fragment. Interacts with SFN. Associates with U4/U6-U5 tri-small nuclear
ribonucleoproteins (U4/U6-U5 tri-snRNPs)
Sequence caution: Sequence=AAQ63886.1; Type=Miscellaneous discrepancy; Note=The cDNA appears to contain a
duplicated region;
1 PDB 3D structure from and Proteopedia for SRPK2:
2X7G (3D)    
Secondary accessions: A8MVX2 O75220 O75221 Q6NUL0 Q6V1X2 Q8IYQ3
Alternative splicing: 2 isoforms:  P78362-1   P78362-2   

Explore the universe of human proteins at neXtProt for SRPK2: NX_P78362

Explore proteomics data for SRPK2 at MOPED

Post-translational modifications: 

  • Phosphorylation at Thr-492 by PKB/AKT1 enhances its stimulatory activity in triggering cyclin-D1 (CCND1)
    expression and promoting apoptosis in neurons, which can be blocked by YWHAB. It also enhances its protein kinase
    activity toward ACIN1 and SRSF2, promotes its nuclear translocation and prevents its proteolytic cleavage1
  • Proteolytically cleaved at Asp-139 and Asp-403 by caspase-3 during apoptotic cell death. Cleavage at Asp-139 which
    is the major site of cleavage, produces a small N-terminal fragment that translocates into nucleus and promotes
    VP16-induced apoptosis1
  • Ubiquitination2 at Lys179, Lys527, Lys539, Lys618
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for SRPK2 (P78362) (see all 18)
     DLGNACW  DYCKGGY  FNGRYHV  YSRDEDH 


    See SRPK2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001265202.1  NP_872633.1  NP_872634.1  

    ENSEMBL proteins: 
     ENSP00000417946   ENSP00000377262   ENSP00000349863   ENSP00000420208   ENSP00000419791  
     ENSP00000418786   ENSP00000419240   ENSP00000417357   ENSP00000417446  

    SRPK2 Human Recombinant Protein Products:

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    Novus Biologicals SRPK2 Proteins
    Novus Biologicals SRPK2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SRPK2

     
    Search eBioscience for Proteins for SRPK2 

    SRPK2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SRPK2
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    Search for Antibodies for SRPK2 at Abcam
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    LSBio Antibodies in human, mouse, rat for SRPK2

    SRPK2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SRPK2
    Cloud-Clone Corp. CLIAs for SRPK2
    Search eBioscience for ELISAs for SRPK2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: SRSF protein kinase 2
    SRPK family

    4 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry P78362

    ProtoNet protein and cluster: P78362

    UniProtKB/Swiss-Prot: SRPK2_HUMAN, P78362
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with SRPK2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRPK2_HUMAN, P78362
    Function: Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine
    residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the
    phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by
    up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the
    suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1)
    expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in
    cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complex formation via the
    phosphorylation of DDX23/PRP28. Can mediate hepatitis B virus (HBV) core protein phosphorylation. Plays a
    negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the
    core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the
    formation of the viral core particles
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation on Ser-52 and Ser-588 (By similarity)

         Genatlas biochemistry entry for SRPK2:
    splicing factor,RS domain protein kinase 2,highly specific for the serine/arginine repeats,modulating the affinity
    between RS domain containing proteins and regulating the cellular distribution of their substrates

         Enzyme Number (IUBMB): EC 2.7.11.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA9472028
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA9472028
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI16189514
         
    Find genes that share ontologies with SRPK2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SRPK2:
     Stronger migration 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Srpk2):
     hematopoietic system  immune system  mortality/aging  normal  tumorigenesis 

    Find genes that share phenotypes with SRPK2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SRPK2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SRPK2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SRPK2

    miRNA
    Products:
        
    miRTarBase miRNAs that target SRPK2:
    hsa-mir-21-5p (MIRT030965), hsa-mir-155-5p (MIRT020912), hsa-mir-181a-5p (MIRT025155)

    Block miRNA regulation of human, mouse, rat SRPK2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SRPK2 (see all 54):
    hsa-miR-549 hsa-miR-24-1* hsa-miR-106a hsa-miR-25 hsa-miR-128 hsa-miR-374a hsa-miR-371-5p hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidSRPK2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SRPK2
    Predesigned siRNA for gene silencing in human, mouse, rat SRPK2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): SRPK2 (NM_182691)
    Sino Biological Human cDNA Clone for SRPK2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRPK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRPK2
    Addgene plasmids for SRPK2 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRPK2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SRPK2_HUMAN, P78362: Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. KAT5/TIP60 inhibits
    its nuclear translocation. Phosphorylation at Thr-492 by PKB/AKT1 promotes nuclear translocation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with SRPK2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SRPK2 About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA processing0.44


    1 BioSystems Pathway for SRPK2
        mRNA processing



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SRPK2
    Interactions:

        GeneGlobe Interaction Network for SRPK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SRPK2 (P783621, 2, 3 ENSP000003772624) via UniProtKB, MINT, STRING, and/or I2D (see all 180)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SNRNP70P086211, 2, 3, ENSP000002214484EBI-593303,EBI-1049228 MINT-8332921 I2D: score=1 STRING: ENSP00000221448
    SRSF2Q011302, 3, ENSP000003508774MINT-8143252 I2D: score=1 STRING: ENSP00000350877
    ARGLU1Q9NWB61, 2, ENSP000003830594EBI-593303,EBI-2808785 MINT-8338828 STRING: ENSP00000383059
    RBM39Q144981, 2, ENSP000002533634EBI-593303,EBI-395290 MINT-8335429 STRING: ENSP00000253363
    SNRNP27Q8WVK21, 2, ENSP000002442274EBI-593303,EBI-2512550 MINT-8339169 STRING: ENSP00000244227
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000245spliceosomal complex assembly IDA9472028
    GO:0001525angiogenesis ISS--
    GO:0006468protein phosphorylation IDA9472028
    GO:0008284positive regulation of cell proliferation IDA18559500
    GO:0008380RNA splicing IDA9472028

    Find genes that share ontologies with SRPK2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SRPK2

    3 HMDB Compounds for SRPK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    4 DrugBank Compounds for SRPK2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenine1H-Purin-6-amine (see all 5)73-24-5target--10592235
    Adenosine-5'-Diphosphate-- 20398-34-9target--10592235
    Phosphoaminophosphonic Acid-Adenylate Ester-- --target--10592235
    Purvalanol-- --target--10592235

    1 Novoseek inferred chemical compound relationship for SRPK2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 47.7 3 10198174 (1), 12417631 (1)



    Find genes that share compounds with SRPK2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SRPK2 gene (3 alternative transcripts): 
    NM_001278273.1  NM_182691.2  NM_182692.2  

    Unigene Cluster for SRPK2:

    SRSF protein kinase 2
    Hs.285197  [show with all ESTs]
    Unigene Representative Sequence: U88666
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000493638 ENST00000465072(uc003vcs.1) ENST00000393651(uc003vcv.3)
    ENST00000357311(uc003vct.3 uc003vcu.3) ENST00000466917 ENST00000485455
    ENST00000477925 ENST00000489828(uc003vcw.1) ENST00000474770 ENST00000476117
    ENST00000482897 ENST00000460391 ENST00000462282 ENST00000465112 ENST00000482862

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    Selected qRT-PCR Assays for microRNAs that regulate SRPK2 (see all 54):
    hsa-miR-549 hsa-miR-24-1* hsa-miR-106a hsa-miR-25 hsa-miR-128 hsa-miR-374a hsa-miR-371-5p hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidSRPK2 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK093420.1 AY354201.1 BC035214.1 BC068547.1 U88666.1 

    20 DOTS entries:

    DT.417966  DT.101985161  DT.121104840  DT.100820057  DT.100677445  DT.102843248  DT.95176371  DT.75104145 
    DT.95108119  DT.97775823  DT.95176367  DT.102843247  DT.100028528  DT.436356  DT.95138976  DT.95176368 
    DT.40234362  DT.75145902  DT.91647477  DT.95189368 

    Selected AceView cDNA sequences (see all 328):

    BQ428104 AW016345 AW070439 BX094777 AI038250 BP357488 BM829170 BP374703 
    AA904398 BM510112 H05064 BF513736 AI199780 AL705494 AI383443 BM746570 
    AA435517 BQ921654 BU607396 BQ022483 AY222296 AW086157 AL705522 AI075315 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SRPK2 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c
    SP1:                                                                                                  -                     
    SP2:                                                                                                                        
    SP3:                                                                                                                        
    SP4:                                                                                            -                           
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for SRPK2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SRPK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAACGAAGTT
    SRPK2 Expression
    About this image


    SRPK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Monocytes Peripheral Blood
     
     Testis (Reproductive System)
    SRPK2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SRPK2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.285197

    UniProtKB/Swiss-Prot: SRPK2_HUMAN, P78362
    Tissue specificity: Highly expressed in brain, moderately expressed in heart and skeletal muscle and at low levels
    in lung, liver, and kidney

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SRPK2 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srpk21 , 5 serine/arginine-rich protein specific kinase 21, 5 90.55(n)1
    94.96(a)1
      5 (10.36 cM)5
    208171  NM_009274.21  NP_033300.21 
     235033565 
    chicken
    (Gallus gallus)
    Aves SRPK21 SRSF protein kinase 2 83.78(n)
    91.24(a)
      417711  XM_415955.4  XP_415955.4 
    lizard
    (Anolis carolinensis)
    Reptilia SRPK26
    SRSF protein kinase 2
    84(a)
    1 ↔ 1
    5(96487225-96615733)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.65962 Xenopus laevis transcribed sequence with moderate similarity more 80.37(n)    BJ100231.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003332931 SRSF protein kinase 2-like 70.16(n)
    78.01(a)
      100333293  XM_002666756.3  XP_002666802.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta SRPK3 protein amino acid phosphorylation
    protein kinase
    71(a)
    (best of 3)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea spk-16
    Protein SPK-1, isoform b
    29(a)
    1 → many
    III(9456563-9462960) WBGene00004980
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SKY16
    SR protein kinase (SRPK) involved in regulating pr...
    30(a)
    1 → many
    XIII(698811-701039) YMR216C
    wheat
    (Triticum aestivum)
    Liliopsida BT009133.12   -- 74.06(n)    BT009133.1 


    ENSEMBL Gene Tree for SRPK2 (if available)
    TreeFam Gene Tree for SRPK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SRPK2 gene
    SRPK32  SRPK12  
    3 SIMAP similar genes for SRPK2 using alignment to 8 protein entries:     SRPK2_HUMAN (see all proteins):
    SRPK1    SRPK3    CDK4

    Find genes that share paralogs with SRPK2           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for SRPK2
    PGOHUM00000243475 PGOHUM00000249362 PGOHUM00000260438


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SRPK2 (see all 5981)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0411154
    A glioblastoma multiforme sample4--see VAR_0411152 G D mis40--------
    rs665092071,2
    C--104259562(-) CTTTC-/TT/TTT
            
    TTTTT
    2 -- int12NA 4
    rs11421,2
    C,F,A,H--104756326(+) TTTCTC/TATAGA 2 -- ds500121Minor allele frequency- T:0.29EA MN NA NS WA CSA 6062
    rs11431,2
    C,F,A,H--104756344(+) GATAGT/CATCAC 2 -- ds500134Minor allele frequency- C:0.36EA MN NS NA WA CSA 7446
    rs11441,2
    C,F,A,H--104756355(+) CAGTCT/CACAGC 2 -- ds500121Minor allele frequency- C:0.32EA MN NA NS CSA WA 5730
    rs1807571411,2
    --104756376(+) CACAGA/TATTTA 2 -- ds50010--------
    rs1469511701,2
    C--104756392(+) AAACCC/TACAGC 2 -- ds50010--------
    rs1860943671,2
    --104756519(+) CCTAAC/TAGCAA 2 -- ds50010--------
    rs121124581,2
    C,F,H--104756582(+) TTTGAT/AGAACC 2 -- ds500110Minor allele frequency- A:0.04NS EA NA WA 1204
    rs1918151991,2
    C--104756624(+) GAATCA/CATCTA 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for SRPK2 (104751151 - 105001151 bp, first 250kb of SRPK2)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SRPK2 (see all 23):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734969CNV Deletion23290073
    esv4403CNV Deletion18987735
    esv2734971CNV Deletion23290073
    esv2002456CNV Deletion18987734
    esv1372047CNV Deletion17803354
    esv2734970CNV Deletion23290073
    esv2663587CNV Deletion23128226
    esv2657876CNV Deletion23128226
    esv2734968CNV Deletion23290073
    nsv436902CNV Insertion17901297

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602980    OMIM disorders: --


    Find genes that share disorders with SRPK2           About GenesLikeMe

    Genetic Association Database (GAD): SRPK2
    Human Genome Epidemiology (HuGE) Navigator: SRPK2 (1 document)

    Export disorders for SRPK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SRPK2 gene, integrated from 10 sources (see all 53):
    (articles sorted by number of sources associating them with SRPK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells. (PubMed id 9472028)1, 2, 3 Wang H.-Y.... Fu X.-D. (J. Cell Biol. 1998)
    2. Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome. (PubMed id 18425142)1, 2, 9 Mathew R....Luehrmann R. (Nat. Struct. Mol. Biol. 2008)
    3. Acetylation and phosphorylation of SRSF2 control cell fate decision in response to cisplatin. (PubMed id 21157427)1, 2 Edmond V.... Eymin B. (EMBO J. 2011)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons. (PubMed id 19592491)1, 2 Jang S.W.... Ye K. (J. Biol. Chem. 2009)
    6. Serine/arginine protein-specific kinase 2 promotes leukemia cell proliferation by phosphorylating acinus and regulating cyclin A1. (PubMed id 18559500)1, 2 Jang S.W.... Ye K. (Cancer Res. 2008)
    7. Suppression of hepatitis B virus replication by SRPK1 and SRPK2 via a pathway independent of the phosphorylation of the viral core protein. (PubMed id 16122776)1, 2 Zheng Y.... Ou J.H. (Virology 2005)
    8. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (Anal. Chem. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6733 HGNC: 11306 AceView: SRPK2 Ensembl:ENSG00000135250 euGenes: HUgn6733
    ECgene: SRPK2 H-InvDB: SRPK2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SRPK2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SRPK2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SRPK2 gene:
    Search GeneIP for patents involving SRPK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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