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Aliases for SRPK2 Gene

Aliases for SRPK2 Gene

  • SRSF Protein Kinase 2 2 3
  • SFRS Protein Kinase 2 2 3 4
  • Serine/Arginine-Rich Protein-Specific Kinase 2 3 4
  • Serine/Arginine-Rich Splicing Factor Kinase 2 2 3
  • SR-Protein-Specific Kinase 2 3 4
  • SR Protein Kinase 2 2 3
  • EC 2.7.11.1 4 63
  • Serine/Threonine-Protein Kinase SRPK2 3
  • Serine Kinase SRPK2 3
  • SFRSK2 3

External Ids for SRPK2 Gene

Summaries for SRPK2 Gene

GeneCards Summary for SRPK2 Gene

SRPK2 (SRSF Protein Kinase 2) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway. GO annotations related to this gene include protein serine/threonine kinase activity and 14-3-3 protein binding. An important paralog of this gene is SRPK1.

UniProtKB/Swiss-Prot for SRPK2 Gene

  • Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. Can mediate hepatitis B virus (HBV) core protein phosphorylation. Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles.

Gene Wiki entry for SRPK2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRPK2 Gene

Genomics for SRPK2 Gene

Genomic Location for SRPK2 Gene

Start:
105,110,704 bp from pter
End:
105,399,308 bp from pter
Size:
288,605 bases
Orientation:
Minus strand

Genomic View for SRPK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SRPK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRPK2 Gene

Regulatory Elements for SRPK2 Gene

Proteins for SRPK2 Gene

  • Protein details for SRPK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78362-SRPK2_HUMAN
    Recommended name:
    SRSF protein kinase 2
    Protein Accession:
    P78362
    Secondary Accessions:
    • A8MVX2
    • O75220
    • O75221
    • Q6NUL0
    • Q6V1X2
    • Q8IYQ3

    Protein attributes for SRPK2 Gene

    Size:
    688 amino acids
    Molecular mass:
    77527 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with PKB/AKT1 in a phosphorylation-dependent manner. The phosphorylated form (by PKB/AKT1) interacts with YWHAB and YWHAE. Interaction with YWHAB suppresses its cleavage by caspases and inhibits the release of its N-terminal pro-apoptotic fragment. Interacts with SFN. Associates with U4/U6-U5 tri-small nuclear ribonucleoproteins (U4/U6-U5 tri-snRNPs).
    SequenceCaution:
    • Sequence=AAQ63886.1; Type=Miscellaneous discrepancy; Note=The cDNA appears to contain a duplicated region.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SRPK2 Gene

    Alternative splice isoforms for SRPK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRPK2 Gene

Proteomics data for SRPK2 Gene at MOPED

Post-translational modifications for SRPK2 Gene

  • Phosphorylation at Thr-492 by PKB/AKT1 enhances its stimulatory activity in triggering cyclin-D1 (CCND1) expression and promoting apoptosis in neurons, which can be blocked by YWHAB. It also enhances its protein kinase activity toward ACIN1 and SRSF2, promotes its nuclear translocation and prevents its proteolytic cleavage.
  • Proteolytically cleaved at Asp-139 and Asp-403 by caspase-3 during apoptotic cell death. Cleavage at Asp-139 which is the major site of cleavage, produces a small N-terminal fragment that translocates into nucleus and promotes VP16-induced apoptosis
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys179, Lys527, Lys539, and Lys618

Domains for SRPK2 Gene

Gene Families for SRPK2 Gene

Protein Domains for SRPK2 Gene

Suggested Antigen Peptide Sequences for SRPK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P78362

UniProtKB/Swiss-Prot:

SRPK2_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • P78362
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.:
    • P78362
genes like me logo Genes that share domains with SRPK2: view

Function for SRPK2 Gene

Molecular function for SRPK2 Gene

GENATLAS Biochemistry: splicing factor,RS domain protein kinase 2,highly specific for the serine/arginine repeats,modulating the affinity between RS domain containing proteins and regulating the cellular distribution of their substrates
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by phosphorylation on Ser-52 and Ser-588.
UniProtKB/Swiss-Prot Function: Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. Can mediate hepatitis B virus (HBV) core protein phosphorylation. Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles.

Enzyme Numbers (IUBMB) for SRPK2 Gene

Gene Ontology (GO) - Molecular Function for SRPK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 9472028
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 9472028
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with SRPK2: view

Phenotypes for SRPK2 Gene

genes like me logo Genes that share phenotypes with SRPK2: view

miRNA for SRPK2 Gene

miRTarBase miRNAs that target SRPK2

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for SRPK2 Gene

Localization for SRPK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRPK2 Gene

Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. KAT5/TIP60 inhibits its nuclear translocation. Phosphorylation at Thr-492 by PKB/AKT1 promotes nuclear translocation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRPK2 Gene COMPARTMENTS Subcellular localization image for SRPK2 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SRPK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with SRPK2: view

Pathways for SRPK2 Gene

SuperPathways for SRPK2 Gene

Superpath Contained pathways
1 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with SRPK2: view

Pathways by source for SRPK2 Gene

1 BioSystems pathway for SRPK2 Gene

Gene Ontology (GO) - Biological Process for SRPK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000245 spliceosomal complex assembly IDA 9472028
GO:0001525 angiogenesis ISS --
GO:0006468 protein phosphorylation IDA 9472028
GO:0008152 metabolic process --
GO:0008284 positive regulation of cell proliferation IDA 18559500
genes like me logo Genes that share ontologies with SRPK2: view

Compounds for SRPK2 Gene

(3) HMDB Compounds for SRPK2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4

(4) Drugbank Compounds for SRPK2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Adenine
  • 1H-Purin-6-amine
73-24-5 target
Adenosine-5'-Diphosphate
20398-34-9 target
Phosphoaminophosphonic Acid-Adenylate Ester
target
Purvalanol
target

(1) Novoseek inferred chemical compound relationships for SRPK2 Gene

Compound -log(P) Hits PubMed IDs
serine 47.7 2
genes like me logo Genes that share compounds with SRPK2: view

Transcripts for SRPK2 Gene

Unigene Clusters for SRPK2 Gene

SRSF protein kinase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SRPK2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c
SP1: -
SP2:
SP3:
SP4: -
SP5:
SP6:

Relevant External Links for SRPK2 Gene

GeneLoc Exon Structure for
SRPK2
ECgene alternative splicing isoforms for
SRPK2

Expression for SRPK2 Gene

mRNA expression in normal human tissues for SRPK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SRPK2 Gene

SOURCE GeneReport for Unigene cluster for SRPK2 Gene Hs.285197

mRNA Expression by UniProt/SwissProt for SRPK2 Gene

P78362-SRPK2_HUMAN
Tissue specificity: Highly expressed in brain, moderately expressed in heart and skeletal muscle and at low levels in lung, liver, and kidney.
genes like me logo Genes that share expressions with SRPK2: view

No data available for mRNA differential expression in normal tissues for SRPK2 Gene

Orthologs for SRPK2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SRPK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRPK2 35
  • 98.57 (n)
  • 98.71 (a)
SRPK2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SRPK2 35
  • 92.34 (n)
  • 96.72 (a)
SRPK2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRPK2 35
  • 92.03 (n)
  • 96.09 (a)
SRPK2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srpk2 35
  • 90.55 (n)
  • 94.96 (a)
Srpk2 16
Srpk2 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SRPK2 36
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRPK2 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Srpk2 35
  • 88.98 (n)
  • 93.39 (a)
chicken
(Gallus gallus)
Aves SRPK2 35
  • 83.78 (n)
  • 91.24 (a)
SRPK2 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRPK2 36
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6596 35
tropical clawed frog
(Silurana tropicalis)
Amphibia srpk3 35
  • 77.6 (n)
  • 85.49 (a)
Str.3989 35
zebrafish
(Danio rerio)
Actinopterygii LOC100333293 35
  • 70.16 (n)
  • 78.01 (a)
SRPK2 36
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta SRPK 36
  • 42 (a)
OneToMany
SRPK 37
  • 71 (a)
BEST:CK01209 37
  • 56 (a)
CG8565 37
  • 43 (a)
worm
(Caenorhabditis elegans)
Secernentea spk-1 36
  • 29 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SKY1 36
  • 30 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3959 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
OneToMany
Species with no ortholog for SRPK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRPK2 Gene

ENSEMBL:
Gene Tree for SRPK2 (if available)
TreeFam:
Gene Tree for SRPK2 (if available)

Paralogs for SRPK2 Gene

Paralogs for SRPK2 Gene

Selected SIMAP similar genes for SRPK2 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for SRPK2 Gene

genes like me logo Genes that share paralogs with SRPK2: view

Variants for SRPK2 Gene

Sequence variations from dbSNP and Humsavar for SRPK2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1142 -- 105,115,879(+) TTTCT(C/T)ATAGA intron-variant, utr-variant-3-prime
rs1143 -- 105,115,897(+) GATAG(C/T)ATCAC intron-variant, utr-variant-3-prime
rs1144 -- 105,115,908(+) CAGTC(C/T)ACAGC intron-variant, utr-variant-3-prime
rs41562 -- 105,204,647(+) CGACA(C/T)GTGAG intron-variant
rs41563 -- 105,212,207(+) AGAAA(A/G)ACTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRPK2 Gene

Variant ID Type Subtype PubMed ID
nsv436902 CNV Insertion 17901297
nsv888927 CNV Loss 21882294
dgv237e55 CNV Gain 17911159
dgv2122e1 CNV Complex 17122850
nsv8196 CNV Gain 18304495
esv6303 CNV Gain 19470904
esv270521 CNV Insertion 20981092
esv273741 CNV Insertion 20981092
nsv888928 CNV Loss 21882294
esv27705 CNV Loss 19812545
esv2657876 CNV Deletion 23128226
esv1250386 CNV Insertion 17803354
esv2663587 CNV Deletion 23128226
esv2734968 CNV Deletion 23290073
esv2002456 CNV Deletion 18987734
esv4403 CNV Deletion 18987735
esv2734969 CNV Deletion 23290073
nsv366339 CNV Loss 16902084
esv2734970 CNV Deletion 23290073
esv1372047 CNV Deletion 17803354
dgv7436n71 CNV Gain 21882294
esv2734971 CNV Deletion 23290073
nsv888934 CNV Loss 21882294

Relevant External Links for SRPK2 Gene

HapMap Linkage Disequilibrium report
SRPK2
Human Gene Mutation Database (HGMD)
SRPK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRPK2 Gene

Disorders for SRPK2 Gene

Relevant External Links for SRPK2

Genetic Association Database (GAD)
SRPK2
Human Genome Epidemiology (HuGE) Navigator
SRPK2
genes like me logo Genes that share disorders with SRPK2: view

No data available for UniProtKB/Swiss-Prot for SRPK2 Gene

Publications for SRPK2 Gene

  1. Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome. (PMID: 18425142) Mathew R. … Luehrmann R. (Nat. Struct. Mol. Biol. 2008) 3 4 23
  2. SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells. (PMID: 9472028) Wang H.-Y. … Fu X.-D. (J. Cell Biol. 1998) 2 3 4
  3. Identification of SRPK1 and SRPK2 as the major cellular protein kinases phosphorylating hepatitis B virus core protein. (PMID: 12134018) Daub H. … Cotten M. (J. Virol. 2002) 3 4
  4. A serine kinase regulates intracellular localization of splicing factors in the cell cycle. (PMID: 8208298) Gui J.F. … Fu X.-D. (Nature 1994) 2 3
  5. The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs). (PMID: 10196197) Koizumi J. … Hagiwara M. (J. Biol. Chem. 1999) 3 23

Products for SRPK2 Gene

  • Addgene plasmids for SRPK2

Sources for SRPK2 Gene

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