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SRPK1 Gene

protein-coding   GIFtS: 67
GCID: GC06M035898

SRSF Protein Kinase 1

(Previous name: SFRS protein kinase 1)
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Aliases
for SRPK1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SRSF Protein Kinase 11 2     SR Protein Kinase 11
SFRS Protein Kinase 11 2 3     SFRSK12
Serine/Arginine-Rich Splicing Factor Kinase 11 2     Serine/Threonine-Protein Kinase SRPK12
SR-Protein-Specific Kinase 12 3     Serine/Arginine-Rich Protein-Specific Kinase 13
EC 2.7.11.13 8     

External Ids:    HGNC: 113051   Entrez Gene: 67322   Ensembl: ENSG000000960637   OMIM: 6019395   UniProtKB: Q96SB43   

Export aliases for SRPK1 gene to outside databases

Previous GC identifers: GC06M035802 GC06M035847 GC06M035908 GC06M035518 GC06M035801


Summaries
for SRPK1 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SRPK1 Gene:
This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of
splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in
regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing
factors. Alternative splicing of this gene results in multiple transcript variants. Additional alternatively
spliced transcript variants have been described for this gene, but their full length nature have not been
determined.(provided by RefSeq, Jul 2010)

GeneCards Summary for SRPK1 Gene:
SRPK1 (SRSF protein kinase 1) is a protein-coding gene. Diseases associated with SRPK1 include coffin-lowry syndrome, and familial hypercholesterolemia. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is SRPK3.

UniProtKB/Swiss-Prot: SRPK1_HUMAN, Q96SB4
Function: Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine
residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the
phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory
network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the
reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as
other cellular activities, such as chromatin reorganization in somatic and sperm cells and cell cycle
progression. Isoform 2 phosphorylates SFRS2, ZRSR2, LBR and PRM1. Isoform 2 phosphorylates SRSF1 using a
directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation
(in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive
phosphorylation steps (in which the kinase and substrate dissociate after each phosphorylation event). The RS
domain of SRSF1 binds first to a docking groove in the large lobe of the kinase domain of SRPK1. This induces
certain structural changes in SRPK1 and/or RRM2 domain of SRSF1, allowing RRM2 to bind the kinase and initiate
phosphorylation. The cycles continue for several phosphorylation steps in a processive manner (steps 1-8) until
the last few phosphorylation steps (approximately steps 9-12). During that time, a mechanical stress induces the
unfolding of the beta-4 motif in RRM2, which then docks at the docking groove of SRPK1. This also signals RRM2 to
begin to dissociate, which facilitates SRSF1 dissociation after phosphorylation is completed. Isoform 2 can
mediate hepatitis B virus (HBV) core protein phosphorylation. It plays a negative role in the regulation of HBV
replication through a mechanism not involving the phosphorylation of the core protein but by reducing the
packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles.
Isoform 1 and isoform 2 can induce splicing of exon 10 in MAPT/TAU. The ratio of isoform 1/isoform 2 plays a
decisive role in determining cell fate in K-562 leukaemic cell line: isoform 2 favors proliferation where as
isoform 1 favors differentiation

Gene Wiki entry for SRPK1 Gene


Genomic Views
for SRPK1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the SRPK1 gene promoter:
         E2F-4   E2F-3a   E2F-5   AML1a   Lmo2   E2F-2   Egr-2   E2F   E2F-1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SRPK1 promoter sequence
   Search Chromatin IP Primers for SRPK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SRPK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.31   Ensembl cytogenetic band:  6p21.31   HGNC cytogenetic band: 6p21.31

SRPK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRPK1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M035898:  view genomic region     (about GC identifiers)

Start:
 35,800,743 bp from pter      End:
 35,889,119 bp from pter
Size:
 88,377 bases      Orientation:
 minus strand

Proteins
for SRPK1 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SRPK1_HUMAN, Q96SB4 (See protein sequence)
Recommended Name: SRSF protein kinase 1  
Size: 655 amino acids; 74325 Da
Cofactor: Magnesium
Subunit: Monomer. Isoform 2 is found in a multisubunit complex containing seven proteins, named toposome, which
separates entangled circular chromatin DNA during chromosome segregation. Isoform 2 interacts with HHV-1 ICP27
protein. Isoform 2 interacts with DNAJB1/HSP40 and AHSA1/AHA1 and this mediates formation of a complex with the
Hsp70 /Hsp90 machinery. Isoform 1 is found in a complex with: DHX9, MOV10, MATR3, HNRNPU, NCL, DDX21, HSD17B4,
PABPC1, HNRNPM, IGF2BP1, SYNCRIP, RPL3, VIM, YBX1, NPM1, HNRNPA2B1, HNRNPC, RPLP0, RPL7A and RALY. Isoform 2
binds to IGF2BP1, SYNCRIP, HNRNPA2B1 and HNRNPC. Isoform 1 and isoform 2 interact with SAFB which inhibits its
activity. Isoform 2 interacts with SAFB2 which inhibits its activity
Sequence caution: Sequence=CAI20544.1; Type=Erroneous gene model prediction; Sequence=CAI20545.1; Type=Erroneous
gene model prediction;
3 PDB 3D structures from and Proteopedia for SRPK1:
1WAK (3D)        1WBP (3D)        3BEG (3D)    
Secondary accessions: Q12890 Q5R364 Q5R365 Q8IY12
Alternative splicing: 2 isoforms:  Q96SB4-2   Q96SB4-3   (Due to intron retention)

Explore the universe of human proteins at neXtProt for SRPK1: NX_Q96SB4

Explore proteomics data for SRPK1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys215, Lys494, Lys506
  • Modification sites at PhosphoSitePlus
    • Selected DME Specific Peptides for SRPK1 (Q96SB4) (see all 18)
     DLGNACW  PKPADKM  DYCKGGY  FNGRYHV 


    See SRPK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003128.3  
    ENSEMBL proteins: 
     ENSP00000362931   ENSP00000354674   ENSP00000391069   ENSP00000422886   ENSP00000424170  
     ENSP00000425172   ENSP00000424068   ENSP00000424323   ENSP00000362928  

    SRPK1 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant SRPK1 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SRPK1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SRPK1
    GenScript Custom Purified and Recombinant Proteins Services for SRPK1
    Novus Biologicals SRPK1 Proteins
    Novus Biologicals SRPK1 Lysates
    Sino Biological Recombinant Protein for SRPK1
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SRPK1

    SRPK1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals SRPK1 Antibodies
    Abcam antibodies for SRPK1
    Cloud-Clone Corp. Antibodies for SRPK1
    ThermoFisher Antibodies for SRPK1
    LSBio Antibodies in human, mouse, rat for SRPK1

    SRPK1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript SRPK1-Activity-based Kinase Assay for Compound Screening
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SRPK1
    Cloud-Clone Corp. CLIAs for SRPK1

    Domains /
    Families
    for SRPK1 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 IUPHAR Guide to PHARMACOLOGY protein family classification: SRSF protein kinase 1
    SRPK family

    4 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q96SB4

    ProtoNet protein and cluster: Q96SB4

    UniProtKB/Swiss-Prot: SRPK1_HUMAN, Q96SB4
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    SRPK1 for domains           About GeneDecksing


    Function
    for SRPK1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRPK1_HUMAN, Q96SB4
    Function: Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine
    residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the
    phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory
    network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the
    reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as
    other cellular activities, such as chromatin reorganization in somatic and sperm cells and cell cycle
    progression. Isoform 2 phosphorylates SFRS2, ZRSR2, LBR and PRM1. Isoform 2 phosphorylates SRSF1 using a
    directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation
    (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive
    phosphorylation steps (in which the kinase and substrate dissociate after each phosphorylation event). The RS
    domain of SRSF1 binds first to a docking groove in the large lobe of the kinase domain of SRPK1. This induces
    certain structural changes in SRPK1 and/or RRM2 domain of SRSF1, allowing RRM2 to bind the kinase and initiate
    phosphorylation. The cycles continue for several phosphorylation steps in a processive manner (steps 1-8) until
    the last few phosphorylation steps (approximately steps 9-12). During that time, a mechanical stress induces the
    unfolding of the beta-4 motif in RRM2, which then docks at the docking groove of SRPK1. This also signals RRM2 to
    begin to dissociate, which facilitates SRSF1 dissociation after phosphorylation is completed. Isoform 2 can
    mediate hepatitis B virus (HBV) core protein phosphorylation. It plays a negative role in the regulation of HBV
    replication through a mechanism not involving the phosphorylation of the core protein but by reducing the
    packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles.
    Isoform 1 and isoform 2 can induce splicing of exon 10 in MAPT/TAU. The ratio of isoform 1/isoform 2 plays a
    decisive role in determining cell fate in K-562 leukaemic cell line: isoform 2 favors proliferation where as
    isoform 1 favors differentiation
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation on Ser-51 and Ser-555

         Genatlas biochemistry entry for SRPK1:
    splicing factor,RS domain protein kinase 1,highly specific for the serine/arginine repeats,modulating the affinity
    between RS domain containing proteins and regulating the cellular distribution of their substrates

         Enzyme Number (IUBMB): EC 2.7.11.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA11509566
    GO:0004672protein kinase activity TAS8208298
    GO:0004674protein serine/threonine kinase activity IDA11509566
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI10196197
         
    SRPK1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SRPK1:
     Decreased Hepatitis C virus re 

         1 MGI phenotypic allele for Srpk1 (no phenotypes)

    SRPK1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SRPK1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SRPK1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SRPK1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SRPK1

    miRNA
    Products:            		miRTarBase miRNAs that target SRPK1:
    hsa-mir-16-5p (MIRT031711), hsa-mir-652-3p (MIRT039559), hsa-mir-99a-5p (MIRT048634), hsa-mir-186-5p (MIRT045199), hsa-mir-93-5p (MIRT028016)

    Block miRNA regulation of human, mouse, rat SRPK1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SRPK1 (see all 21):
    hsa-miR-520d-5p hsa-miR-15a hsa-miR-424 hsa-miR-149 hsa-miR-133a hsa-miR-186 hsa-miR-29a* hsa-miR-129-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SRPK1 3' UTR sequence
    Inhib. RNA
    Products:            		OriGene RNAi products in human, mouse, rat for SRPK1
    Predesigned siRNA for gene silencing in human, mouse, rat SRPK1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SRPK1

    Clone
    Products:             		 OriGene clones in human, mouse for SRPK1 (see all 7)
    OriGene ORF clones in mouse, rat for SRPK1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SRPK1 (NM_003137)
    Sino Biological Human cDNA Clone for SRPK1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRPK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRPK1

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SRPK1
    Browse ESI BIO Cell Lines and PureStem Progenitors for SRPK1 
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRPK1


    Localization
    for SRPK1 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Subcellular locations from UniProtKB/Swiss-Prot
    SRPK1_HUMAN, Q96SB4: Isoform 2: Cytoplasm. Nucleus. Nucleus matrix. Microsome. Note=Shuttles between the nucleus
    and the cytoplasm. Inhibition of the Hsp90 ATPase activity, osmotic stress and interaction with HHV-1 ICP27
    protein can induce its translocation to the nucleus. KAT5/TIP60 inhibits its nuclear translocation
    SRPK1_HUMAN, Q96SB4: Isoform 1: Cytoplasm. Nucleus matrix. Microsome. Note=Mainly localized in the microsomal
    fraction and the cytoplasm, and to a lesser extent in the nuclear matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    endoplasmic reticulum3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005783endoplasmic reticulum IEA--
    GO:0005886plasma membrane IDA--
    GO:0016363nuclear matrix IEA--

    SRPK1 for ontologies           About GeneDecksing


    Pathways & Interactions
    for SRPK1 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SRPK1 About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    		mRNA processing0.44
    2Influenza A
    		Herpes simplex infection0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SRPK1
        mRNA processing



    1 Kegg Pathway  (Kegg details for SRPK1):
        Herpes simplex infection


    SRPK1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SRPK1
    Interactions:

        GeneGlobe Interaction Network for SRPK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SRPK1 (Q96SB41, 2, 3 ENSP000003910694) via UniProtKB, MINT, STRING, and/or I2D (see all 164)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SAFBQ154241, 2, 3, ENSP000002921234EBI-7160164,EBI-348298 MINT-7228207 MINT-7228500 MINT-7228466 MINT-7228438 I2D: score=2 STRING: ENSP00000292123
    TP53P046371, 2, ENSP000002693054EBI-539478,EBI-366083 MINT-8074644 MINT-8074754 MINT-8074706 STRING: ENSP00000269305
    SRPK2P783622, 3, ENSP000003772624MINT-8143270 MINT-8143252 I2D: score=2 STRING: ENSP00000377262
    SRSF1Q079551, 3, ENSP000002589624EBI-539478,EBI-398920 I2D: score=5 STRING: ENSP00000258962
    YWHAGP619812, 3, ENSP000003063304MINT-50794 I2D: score=3 STRING: ENSP00000306330
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0006468protein phosphorylation IDA11509566
    GO:0007059chromosome segregation IDA15034300
    GO:0008380RNA splicing IEA--
    GO:0016032viral process IEA--

    SRPK1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SRPK1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SRPK1

    3 HMDB Compounds for SRPK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    5 Novoseek inferred chemical compound relationships for SRPK1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dsk-1 89.8 4 10629038 (2), 9488736 (1)
    serine 69.3 16 15034300 (1), 10198174 (1), 16042687 (1), 17823247 (1) (see all 12)
    arginine 55.3 1 16042687 (1)
    cisplatin 28.9 23 11585720 (5), 17091485 (2), 15256051 (2), 17332336 (1) (see all 5)
    gemcitabine 25 2 17332336 (1), 16585209 (1)



    SRPK1 for compounds           About GeneDecksing



    Transcripts
    for SRPK1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for SRPK1 gene: 
    NM_003137.4  

    Unigene Cluster for SRPK1:

    SRSF protein kinase 1
    Hs.443861  [show with all ESTs]
    Unigene Representative Sequence: NR_034069
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373825(uc011dtg.2 uc003olj.3) ENST00000361690(uc003olh.3)
    ENST00000346162(uc003oli.3) ENST00000423325 ENST00000505885 ENST00000507292
    ENST00000502969 ENST00000510290 ENST00000373821 ENST00000508473 ENST00000512445
    ENST00000513367 ENST00000507909 ENST00000373822
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SRPK1 (see all 21):
    hsa-miR-520d-5p hsa-miR-15a hsa-miR-424 hsa-miR-149 hsa-miR-133a hsa-miR-186 hsa-miR-29a* hsa-miR-129-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SRPK1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SRPK1
    Clone
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    OriGene ORF clones in mouse, rat for SRPK1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SRPK1 (NM_003137)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRPK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRPK1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SRPK1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SRPK1
      QuantiTect SYBR Green Assays in human, mouse, rat SRPK1
      QuantiFast Probe-based Assays in human, mouse, rat SRPK1

    Additional mRNA sequence: 

    AK292277.1 AK299591.1 AK312712.1 AL117648.1 BC038292.1 BX648663.1 BX648697.1 NR_034069.1 

    24 DOTS entries:

    DT.100795211  DT.75122547  DT.91839987  DT.100795210  DT.100795201  DT.91807622  DT.121316775  DT.121316812 
    DT.121316855  DT.91769606  DT.91769620  DT.97815953  DT.100651469  DT.102832643  DT.121316790  DT.121316890 
    DT.121316896  DT.40132187  DT.404253  DT.91769601  DT.95144772  DT.95304775  DT.97844762  DT.121316796 

    Selected AceView cDNA sequences (see all 276):

    AA291188 CD369064 BM835314 BU184563 AA535236 BP376758 BQ231344 BM543123 
    BM806501 AL527881 AI277445 BP369040 F05956 BU539196 AI351151 AA830216 
    BI871617 BX474661 AI458022 BX507312 CR593143 AA535883 BQ431359 CF137979 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SRPK1 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:              -                             -                                                                           
    SP2:              -                             -     -     -                                                               
    SP3:                                                                                                                        
    SP4:              -                                                                                                         
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for SRPK1

    Expression
    for SRPK1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SRPK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACCTTTATT
    SRPK1 Expression
    About this image


    SRPK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Thymus (Hematopoietic System)
             Thymus
     
     Kidney (Urinary System)
             Metanephros
     
     Neural Tube (Nervous System)
             Telencephalon
    SRPK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    SRPK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.443861

    UniProtKB/Swiss-Prot: SRPK1_HUMAN, Q96SB4
    Tissue specificity: Isoform 2 is predominantly expressed in the testis but is also present at lower levels in
    heart, ovary, small intestine, liver, kidney, pancreas and skeletal muscle. Isoform 1 is only seen in the testis,
    at lower levels than isoform 2. Highly expressed in different erythroid and lymphoid cell lines, with isoform 2
    being far more abundant than isoform 1

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    Orthologs
    for SRPK1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SRPK1 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Srpk11 , 5 serine/arginine-rich protein specific kinase 11, 5 89.2(n)1
    92.59(a)1    		   17 (14.78 cM)5
    208151  NM_016795.31  NP_058075.21 
     285876485 
    chicken
    (Gallus gallus)    		 Aves SRPK11 SFRS protein kinase 1 76.1(n)
    81.23(a)    		   421185  XM_419265.4  XP_419265.4 
    lizard
    (Anolis carolinensis)    		 Reptilia SRPK16
    		 SRSF protein kinase 1
    		 78(a)
    		 1 ↔ 1
    		 GL343382.1(685442-726611)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.247742 Xenopus laevis transcribed sequence with moderate similarity more 77.05(n)    BU915013.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufc06h032 wufc06h03 77.53(n)   323679  BC056825.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta SRPK1 , 3 protein amino acid phosphorylation
    protein kinase3
    SRPK1    		 73(a)
    (best of 3)3
    54.41(n)1
    52.29(a)1    		   367061  NM_166093.21  NP_725458.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea spk-16
    		 Protein SPK-1, isoform b
    		 29(a)
    		 1 → many
    		 III(9456563-9462960) WBGene00004980
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes SKY16
    		 SR protein kinase (SRPK) involved in regulating pr...
    		 30(a)
    		 1 → many
    		 XIII(698811-701039) YMR216C
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons SRPK41 SRPK4 60.4(n)
    59.7(a)    		   824469  NM_115163.4  NP_566977.1 
    rice
    (Oryza sativa)    		 Liliopsida Os03g07484001 Os03g0748400 56.96(n)
    57.97(a)    		   4334107  NM_001057803.2  NP_001051268.2 


    ENSEMBL Gene Tree for SRPK1 (if available)
    TreeFam Gene Tree for SRPK1 (if available)

    Paralogs
    for SRPK1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SRPK1 gene
    SRPK32  SRPK22  
    3 SIMAP similar genes for SRPK1 using alignment to 9 protein entries:     SRPK1_HUMAN (see all proteins):
    SRPK2    SRPK3    CDK4

    SRPK1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SRPK1
    PGOHUM00000235099


    Genomic Variants
    for SRPK1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for SRPK1 (see all 1885)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs715401261,2
    		C--35541912(+) CCAAAGTTGG   
       TAT    /-    GTGCT     		2 -- int11Minor allele frequency- -:0.50NA 2
    rs341583801,2
    		C--35578609(+) AAAAACAA/-CAACA 2 -- cds1 int11Minor allele frequency- -:0.50NA 2
    rs105661231,2
    		C--35581390(+) ATGCT-/TG    
           /TGTG    TGTGT     		2 -- int11CSA 2
    rs1472982581,2
    		C--35581390(+) ATGCT-/TGTG  
                TGTGT     		2 -- int10--------
    rs126601071,2
    		C,H--35711559(+) accgcA/Gcccgg 2 -- ds50010--------
    rs1446728491,2
    		--35711625(+) AATCTA/GTCCAA 2 -- ds50010--------
    rs94701201,2
    		C,F,A,H--35711773(+) TTCTGG/AAAGAA 2 -- ds500119Minor allele frequency- A:0.28NS EA NA CSA WA 2344
    rs787120071,2
    		C--35711782(+) AAAGTA/GCTATT 2 -- ds50010--------
    rs1876182151,2
    		--35711899(+) AACTAG/TGAACC 2 -- ds50010--------
    rs126601511,2
    		C,F,H--35711914(+) AAAATG/AGCAAG 2 -- ds500116Minor allele frequency- A:0.04NS EA NA WA 2336

    HapMap Linkage Disequilibrium report for SRPK1 (35800743 - 35889119 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for SRPK1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2676075CNV Deletion23128226
    esv2731915CNV Deletion23290073
    nsv821646CNV Loss15273396
    dgv6834n71CNV Gain21882294
    nsv428143CNV Gain18775914
    dgv1941e1CNV Complex17122850
    dgv1940e1CNV Complex17122850

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    Disorders / Diseases
    for SRPK1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 601939    OMIM disorders: --

    17 diseases for SRPK1:    
    About MalaCards
    coffin-lowry syndrome    familial hypercholesterolemia    severe acute respiratory syndrome    hypospadias
    cytomegalovirus infection    testicular germ cell tumor    hypercholesterolemia    germ cell tumors
    herpes simplex    retinoblastoma    hepatitis c virus    hepatitis b
    hepatitis    hepatitis c    pancreatitis    cerebritis
    breast cancer


    SRPK1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for SRPK1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 6 17332336 (2), 16585209 (2), 17091485 (1), 15256051 (1)
    cancer 0 3 17332336 (1), 16585209 (1)

    Genetic Association Database (GAD): SRPK1
    Human Genome Epidemiology (HuGE) Navigator: SRPK1 (1 document)

    Export disorders for SRPK1 gene to outside databases

    Publications
    for SRPK1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for SRPK1 gene, integrated from 10 sources (see all 113):
    (articles sorted by number of sources associating them with SRPK1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A serine kinase regulates intracellular localization of splicing factors in the cell cycle. (PubMed id 8208298)1, 2, 3 Gui J.F.... Fu X.-D. (Nature 1994)
    2. SR protein kinase 1 is resilient to inactivation. (PubMed id 17223538)1, 2, 9 Ngo J.C.... Ghosh G. (Structure 2007)
    3. Localization of serine kinases, SRPK1 (SFRSK1) and SRPK2 (SFRSK2), specific for the SR family of splicing factors in mouse and human chromosomes. (PubMed id 10198174)1, 3, 9 Wang H.Y....Fu X.D. (Genomics 1999)
    4. Regiospecific phosphorylation control of the SR protein ASF/SF2 by SRPK1. (PubMed id 19477182)1, 2, 9 Ma C.T.... Adams J.A. (J. Mol. Biol. 2009)
    5. Ordered multi-site phosphorylation of the splicing factor ASF/SF2 by SRPK1. (PubMed id 18155240)1, 2, 9 Ma C.T....Adams J.A. (J. Mol. Biol. 2008)
    6. SR protein-specific kinase 1 is highly expressed in testis and phosphorylates protamine 1. (PubMed id 10390541)1, 2, 9 Papoutsopoulou S.... Giannakouros T. (Nucleic Acids Res. 1999)
    7. The enzymatic activity of SR protein kinases 1 and 1a is negatively affected by interaction with scaffold attachment factors B1 and 2. (PubMed id 19674106)1, 2, 9 Tsianou D....Georgatsou E. (FEBS J. 2009)
    8. Adaptable molecular interactions guide phosphorylation of the SR protein ASF/SF2 by SRPK1. (PubMed id 18687337)1, 2, 9 Hagopian J.C.... Adams J.A. (J. Mol. Biol. 2008)
    9. Protein kinase CK2 phosphorylates and activates the SR protein- specific kinase 1. (PubMed id 12565829)1, 2, 9 Mylonis I. and Giannakouros T. (Biochem. Biophys. Res. Commun. 2003)
    10. Processive phosphorylation of alternative splicing factor/splicing factor 2. (PubMed id 14555757)1, 2, 9 Aubol B.E.... Adams J.A. (Proc. Natl. Acad. Sci. U.S.A. 2003)

    External Searches for SRPK1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

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     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SRPK1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 6732 HGNC: 11305 AceView: SRPK1 Ensembl:ENSG00000096063 euGenes: HUgn6732
    ECgene: SRPK1 Kegg: 6732 H-InvDB: SRPK1

    Other Databases showing SRPK1 gene

    (According to HUGE)
    About This Section

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    Specialized Databases showing SRPK1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SRPK1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SRPK1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for SRPK1 gene:
    Search GeneIP for patents involving SRPK1

    GeneCards and IP:
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