SRPK1 Gene
protein-coding GIFtS: 61
GCID: GC06M035801
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|
SRSF protein kinase 1(Previous name: SFRS protein kinase 1 )
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Aliases
for SRPK1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SRSF Protein Kinase 11 2 | | EC 2.7.11.13 8 | | SFRS Protein Kinase 11 2 3 | | Serine/Arginine-Rich Splicing Factor Kinase 12 | | SFRSK11 2 | | Serine/Threonine-Protein Kinase SRPK12 | | SR-Protein-Specific Kinase 12 3 | | Serine/Arginine-Rich Protein-Specific Kinase 13 |
Export aliases for SRPK1 gene to outside databasesPrevious GC identifers: GC06M035802 GC06M035847 GC06M035908 GC06M035518 |
Summaries
for SRPK1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SRPK1:
This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicingfactors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of bothconstitutive and alternative splicing by regulating intracellular localization of splicing factors. Alternativesplicing of this gene results in multiple transcript variants. Additional alternatively spliced transcript variantshave been described for this gene, but their full length nature have not been determined.(provided by RefSeq, Jul2010)
UniProtKB/Swiss-Prot: SRPK1_HUMAN, Q96SB4Function: Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serineresidues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in thephosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory networkfor splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganizationof nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellularactivities, such as chromatin reorganization in somatic and sperm cells and cell cycle progression. Isoform 2phosphorylates SFRS2, ZRSR2, LBR and PRM1. Isoform 2 phosphorylates SRSF1 using a directional (C-terminal toN-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase staysattached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in which thekinase and substrate dissociate after each phosphorylation event). The RS domain of SRSF1 binds first to a dockinggroove in the large lobe of the kinase domain of SRPK1. This induces certain structural changes in SRPK1 and/or RRM2domain of SRSF1, allowing RRM2 to bind the kinase and initiate phosphorylation. The cycles continue for severalphosphorylation steps in a processive manner (steps 1-8) until the last few phosphorylation steps (approximately steps9-12). During that time, a mechanical stress induces the unfolding of the beta-4 motif in RRM2, which then docks atthe docking groove of SRPK1. This also signals RRM2 to begin to dissociate, which facilitates SRSF1 dissociation afterphosphorylation is completed. Isoform 2 can mediate hepatitis B virus (HBV) core protein phosphorylation. It plays anegative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the coreprotein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of theviral core particles. Isoform 1 and isoform 2 can induce splicing of exon 10 in MAPT/TAU. The ratio of isoform1/isoform 2 plays a decisive role in determining cell fate in K-562 leukaemic cell line: isoform 2 favorsproliferation where as isoform 1 favors differentiation
Gene Wiki entry for SRPK1
|
Genomic Views
for SRPK1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SRPK1 gene promoter:
E2F-4 E2F-3a E2F-5 AML1a Lmo2 E2F-2 Egr-2 E2F E2F-1 aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for SRPK1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRPK1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.31 Ensembl cytogenetic band: 6p21.31 HGNC cytogenetic band: 6p21.31SRPK1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M035801: view genomic region
(about GC identifiers)
Start:
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35,800,743 bp from pter |
End:
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35,889,119 bp from pter |
Size:
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88,377 bases |
Orientation:
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minus strand |
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Proteins
for SRPK1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SRPK1_HUMAN, Q96SB4 (See
protein sequence)Recommended Name: SRSF protein kinase 1 Size: 655 amino acids; 74325 Da
Cofactor: Magnesium
Subunit: Monomer. Isoform 2 is found in a multisubunit complex containing seven proteins, named toposome, whichseparates entangled circular chromatin DNA during chromosome segregation. Isoform 2 interacts with HHV-1 ICP27protein. Isoform 2 interacts with DNAJB1/HSP40 and AHSA1/AHA1 and this mediates formation of a complex with the Hsp70/Hsp90 machinery. Isoform 1 is found in a complex with: DHX9, MOV10, MATR3, HNRNPU, NCL, DDX21, HSD17B4, PABPC1,HNRNPM, IGF2BP1, SYNCRIP, RPL3, VIM, YBX1, NPM1, HNRNPA2B1, HNRNPC, RPLP0, RPL7A and RALY. Isoform 2 binds to IGF2BP1,SYNCRIP, HNRNPA2B1 and HNRNPC. Isoform 1 and isoform 2 interact with SAFB which inhibits its activity. Isoform 2interacts with SAFB2 which inhibits its activity
Subcellular location: Isoform 2: Cytoplasm. Nucleus. Nucleus matrix. Microsome. Note=Shuttles between the nucleus andthe cytoplasm. Inhibition of the Hsp90 ATPase activity, osmotic stress and interaction with HHV-1 ICP27 protein caninduce its translocation to the nucleus. KAT5/TIP60 inhibits its nuclear translocation
Subcellular location: Isoform 1: Cytoplasm. Nucleus matrix. Microsome. Note=Mainly localized in the microsomal fractionand the cytoplasm, and to a lesser extent in the nuclear matrix
Sequence caution: Sequence=CAI20544.1; Type=Erroneous gene model prediction; Sequence=CAI20545.1; Type=Erroneous genemodel prediction;
3 PDB 3D structures from  and Proteopedia  for SRPK1:1WAK (3D)
1WBP (3D)
3BEG (3D)
Secondary accessions: Q12890 Q5R364 Q5R365 Q8IY12Alternative splicing: 2 isoforms: Q96SB4-2 Q96SB4-3 (Due to intron retention)Explore the universe of human proteins at neXtProt for SRPK1: NX_Q96SB4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96SB4
4/18 DME Specific Peptides for SRPK1 (Q96SB4) (see all 18)
SRPK1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003128.3
ENSEMBL proteins: ENSP00000362931 ENSP00000354674 ENSP00000391069 ENSP00000422886 ENSP00000424170 ENSP00000425172 ENSP00000424068 ENSP00000424323 ENSP00000362928
Human Recombinant Protein Products for SRPK1:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
SRPK1 for ontologies About GeneDecksing
SRPK1 Antibody Products:
Assay Products for SRPK1: |
Protein
Domains /
Families
for SRPK1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SRPK1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96SB4ProtoNet protein and cluster: Q96SB4 UniProtKB/Swiss-Prot: SRPK1_HUMAN, Q96SB4Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase familySimilarity: Contains 1 protein kinase domain |
Function
for SRPK1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: SRPK1_HUMAN, Q96SB4Function: Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serineresidues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in thephosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory networkfor splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganizationof nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellularactivities, such as chromatin reorganization in somatic and sperm cells and cell cycle progression. Isoform 2phosphorylates SFRS2, ZRSR2, LBR and PRM1. Isoform 2 phosphorylates SRSF1 using a directional (C-terminal toN-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase staysattached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in which thekinase and substrate dissociate after each phosphorylation event). The RS domain of SRSF1 binds first to a dockinggroove in the large lobe of the kinase domain of SRPK1. This induces certain structural changes in SRPK1 and/or RRM2domain of SRSF1, allowing RRM2 to bind the kinase and initiate phosphorylation. The cycles continue for severalphosphorylation steps in a processive manner (steps 1-8) until the last few phosphorylation steps (approximately steps9-12). During that time, a mechanical stress induces the unfolding of the beta-4 motif in RRM2, which then docks atthe docking groove of SRPK1. This also signals RRM2 to begin to dissociate, which facilitates SRSF1 dissociation afterphosphorylation is completed. Isoform 2 can mediate hepatitis B virus (HBV) core protein phosphorylation. It plays anegative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the coreprotein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of theviral core particles. Isoform 1 and isoform 2 can induce splicing of exon 10 in MAPT/TAU. The ratio of isoform1/isoform 2 plays a decisive role in determining cell fate in K-562 leukaemic cell line: isoform 2 favorsproliferation where as isoform 1 favors differentiationCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Activated by phosphorylation on Ser-51 and Ser-555 Genatlas biochemistry entry for SRPK1:splicing factor,RS domain protein kinase 1,highly specific for the serine/arginine repeats,modulating the affinitybetween RS domain containing proteins and regulating the cellular distribution of their substrates
Enzyme Number (IUBMB): EC 2.7.11.11 2
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
SRPK1 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for SRPK1:
1 MGI phenotypic allele  for Srpk1 (no phenotypes)
SRPK1 for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRPK1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRPK1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SRPK1 (NM_003137) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SRPK1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRPK1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRPK1 |
|
Pathways & Interactions
for SRPK1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | mRNA Splicing - Major Pathway | |
1  BioSystems Pathway for SRPK1
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SRPK1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/67 Interacting proteins for SRPK1 (Q96SB41, 2, 3 ENSP000003910694) via UniProtKB, MINT, STRING, and/or I2D (see all 67)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| SAFB | Q154242, 3, ENSP000002921234 | MINT-7228207 MINT-7228500 MINT-7228466 MINT-7228438 I2D:
score=2 STRING: ENSP00000292123 | | SRPK2 | P783622, 3, ENSP000003772624 | MINT-8143270 MINT-8143252 I2D:
score=2 STRING: ENSP00000377262 | | SRSF1 | Q079551, 3, ENSP000002589624 | EBI-539478,EBI-398920 I2D:
score=5 STRING: ENSP00000258962 | | YWHAG | P619812, 3, ENSP000003063304 | MINT-50794 I2D:
score=3 STRING: ENSP00000306330 | | YWHAB | P319462, 3, ENSP000003001614 | MINT-50939 I2D:
score=2 STRING: ENSP00000300161 |
About this table
Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table
SRPK1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SRPK1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SRPK1 for compounds About GeneDecksing
 Browse Tocris compounds for SRPK1
3 HMDB Compounds for SRPK1 About this table
5 Novoseek chemical compound relationships for SRPK1 gene About this table
Search CenterWatch for drugs/clinical trials and news about SRPK1
|
Transcripts
for SRPK1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SRPK1 gene: NM_003137.4 Unigene Cluster for SRPK1: SRSF protein kinase 1 Hs.443861 [show with all ESTs]Unigene Representative Sequence: NR_03406914 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000373825(uc011dtg.2 uc003olj.3) ENST00000361690(uc003olh.3)
ENST00000423325 ENST00000346162(uc003oli.3) ENST00000505885 ENST00000507292
ENST00000502969 ENST00000510290 ENST00000373821 ENST00000508473 ENST00000512445
ENST00000513367 ENST00000507909 ENST00000373822
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRPK1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRPK1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SRPK1 (NM_003137) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SRPK1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRPK1 |
Additional cDNA sequence: AK292277.1 AK299591.1 AK312712.1 AL117648.1 BC038292.1 BX648663.1 BX648697.1 NR_034069.1 24 DOTS entries: DT.100795211 DT.75122547 DT.91839987 DT.100795210 DT.100795201 DT.91807622 DT.121316775 DT.121316812 DT.121316855 DT.91769606 DT.91769620 DT.97815953 DT.100651469 DT.102832643 DT.121316790 DT.121316890 DT.121316896 DT.40132187 DT.404253 DT.91769601 DT.95144772 DT.95304775 DT.97844762 DT.121316796 24/276 AceView cDNA sequences (see all 276): BI871617 BX474661 AU136595 BU607695 BU632659 AI458022 AI858519 CA425271 AL701811 BU676949 AU139911 AA535236 BG286797 AA535883 AA323127 CA426788 BU539196 BX389409 AW169322 AI351151 AA830216 BQ425174 Z38879 BP376758
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SRPK1 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 |
|---|
|
| SP1: | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SRPK1
|
Expression
for SRPK1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SRPK1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACCTTTATT
About this image
See SRPK1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SRPK1
SOURCE GeneReport for Unigene cluster: Hs.443861
UniProtKB/Swiss-Prot: SRPK1_HUMAN, Q96SB4Tissue specificity: Isoform 2 is predominantly expressed in the testis but is also present at lower levels in heart,ovary, small intestine, liver, kidney, pancreas and skeletal muscle. Isoform 1 is only seen in the testis, at lowerlevels than isoform 2. Highly expressed in different erythroid and lymphoid cell lines, with isoform 2 being far moreabundant than isoform 1
SABiosciences Custom PCR Arrays for SRPK1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SRPK1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SRPK1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRPK1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRPK1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRPK1 |
Orthologs
for SRPK1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SRPK1 gene from 9/35 species (see all 35) About this table
ENSEMBL Gene Tree for SRPK1 (if available)
TreeFam Gene Tree for SRPK1 (if available) |
Paralogs
for SRPK1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SRPK1 gene
- SRPK32 SRPK22
3 SIMAP similar genes for SRPK1 using alignment to 9 protein entries: SRPK1_HUMAN (see all proteins):SRPK2 SRPK3 CDK4
SRPK1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for SRPK1
PGOHUM00000235099
|
Genomic Variants
for SRPK1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SRPK1 (35800743 - 35889119 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SRPK1
2 CNVs: 3607 0286 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SRPK1 |
|
Disorders
/ Diseases
for SRPK1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SRPK1 for disorders About GeneDecksing
OMIM gene information: 601939
OMIM disorders: --
20  diseases for SRPK1: About MalaCardscoffin-lowry syndrome dna topoisomerase i testicular germ cell tumor severe acute respiratory syndrome
germ cell tumor cytomegalovirus infection familial hypercholesterolemia herpes simplex
hypercholesterolemia hypospadias hepatitis c hepatitis b
ovarian carcinoma pancreatic carcinoma colon cancer retinoblastoma
hepatitis pancreatitis carcinoma malaria
2 Novoseek disease relationships for SRPK1 gene About this table
Human Genome Epidemiology (HuGE) Navigator: SRPK1 (1 document)
Export disorders for SRPK1 gene to outside databases
|
Publications
for SRPK1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SRPK1 gene, integrated from 9 sources (see all 102):
(articles sorted by number of sources associating them with SRPK1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A serine kinase regulates intracellular localization of splicing factors in the cell cycle. (PubMed id 8208298)1, 2, 3 Gui J.F.... Fu X.-D. (1994)
- SR protein kinase 1 is resilient to inactivation. (PubMed id 17223538)1, 2, 9 Ngo J.C....Ghosh G. (2007)
- Localization of serine kinases, SRPK1 (SFRSK1) and SR PK2 (SFRSK2), specific for the SR family of splicing factors in mouse and human chromosomes. (PubMed id 10198174)1, 3, 9 Wang H.Y....Fu X.D. (1999)
- Regiospecific phosphorylation control of the SR prote in ASF/SF2 by SRPK1. (PubMed id 19477182)1, 2, 9 Ma C.T....Adams J.A. (2009)
- Ordered multi-site phosphorylation of the splicing factor ASF/SF2 by SRPK1. (PubMed id 18155240)1, 2, 9 Ma C.T....Adams J.A. (2008)
- SR protein-specific kinase 1 is highly expressed in testis and phosphorylates protamine 1. (PubMed id 10390541)1, 2, 9 Papoutsopoulou S....Giannakouros T. (1999)
- The enzymatic activity of SR protein kinases 1 and 1a is negatively affected by interaction with scaffold attachment factors B1 and 2. (PubMed id 19674106)1, 2, 9 Tsianou D....Georgatsou E. (2009)
- Adaptable molecular interactions guide phosphorylation of the SR protein ASF/SF2 by SRPK1. (PubMed id 18687337)1, 2, 9 Hagopian J.C....Adams J.A. (2008)
- Protein kinase CK2 phosphorylates and activates the SR protein- specific kinase 1. (PubMed id 12565829)1, 2, 9 Mylonis I. and Giannakouros T. (2003)
- Processive phosphorylation of alternative splicing factor/splicing factor 2. (PubMed id 14555757)1, 2, 9 Aubol B.E.... Adams J.A. (2003)
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External Searches for SRPK1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing SRPK1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing SRPK1 gene
(According to HUGE)
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Specialized Databases showing SRPK1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for SRPK1 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for SRPK1 gene:
Search GeneIP for patents involving SRPK1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SRPK1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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| | |  | OriGene Antibodies for SRPK1 | | OriGene shRNA RFP for SRPK1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SRPK1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SRPK1 | | | OriGene Protein Over-expression Lysate for SRPK1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SRPK1 | | OriGene 3'-UTR Clone for SRPK1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRPK1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRPK1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SRPK1 | | OriGene Custom Protein Services for SRPK1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SRPK1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SRPK1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRPK1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRPK1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRPK1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRPK1 |
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| | | | Search Tocris compounds for SRPK1 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRPK1 |
|  |  |  |  | | | | ThermoFisher Antibodies for SRPK1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRPK1 |
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