Aliases for SRPK1 Gene
Aliases for SRPK1 Gene
External Ids for SRPK1 Gene
- HGNC: 11305
- Entrez Gene: 6732
- Ensembl: ENSG00000096063
- OMIM: 601939
- UniProtKB: Q96SB4
Previous GeneCards Identifiers for SRPK1 Gene
- GC06M035802
- GC06M035847
- GC06M035908
- GC06M035518
- GC06M035801
- GC06M035898
- GC06M035968
- GC06M036111
- GC06M036306
- GC06M036674
- GC06M037026
- GC06M037376
- GC06M037732
Summaries for SRPK1 Gene
-
This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. Alternative splicing of this gene results in multiple transcript variants. Additional alternatively spliced transcript variants have been described for this gene, but their full length nature have not been determined.[provided by RefSeq, Jul 2010]
GeneCards Summary for SRPK1 Gene
SRPK1 (SRSF Protein Kinase 1) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Influenza A. Gene Ontology (GO) annotations related to this gene include protein kinase activity. An important paralog of this gene is SRPK2.
UniProtKB/Swiss-Prot for SRPK1 Gene
-
Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activities, such as chromatin reorganization in somatic and sperm cells and cell cycle progression. Isoform 2 phosphorylates SFRS2, ZRSR2, LBR and PRM1. Isoform 2 phosphorylates SRSF1 using a directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in which the kinase and substrate dissociate after each phosphorylation event). The RS domain of SRSF1 binds first to a docking groove in the large lobe of the kinase domain of SRPK1. This induces certain structural changes in SRPK1 and/or RRM2 domain of SRSF1, allowing RRM2 to bind the kinase and initiate phosphorylation. The cycles continue for several phosphorylation steps in a processive manner (steps 1-8) until the last few phosphorylation steps (approximately steps 9-12). During that time, a mechanical stress induces the unfolding of the beta-4 motif in RRM2, which then docks at the docking groove of SRPK1. This also signals RRM2 to begin to dissociate, which facilitates SRSF1 dissociation after phosphorylation is completed. Isoform 2 can mediate hepatitis B virus (HBV) core protein phosphorylation. It plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles. Isoform 1 and isoform 2 can induce splicing of exon 10 in MAPT/TAU. The ratio of isoform 1/isoform 2 plays a decisive role in determining cell fate in K-562 leukaemic cell line: isoform 2 favors proliferation where as isoform 1 favors differentiation.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRPK1 Gene
Genomics for SRPK1 Gene
GeneHancer (GH) Regulatory Elements for SRPK1 Gene
Regulatory Element Products
Genomic Locations for SRPK1 Gene
- chr6:35,832,966-35,921,342
- (GRCh38/hg38)
- Size:
- 88,377 bases
- Orientation:
- Minus strand
- chr6:35,800,743-35,889,119
- (GRCh37/hg19)
Genomic View for SRPK1 Gene
- Cytogenetic band:
-
- 6p21.31 by Ensembl
- 6p21.31 by Entrez Gene
- 6p21.31 by HGNC


RefSeq DNA sequence for SRPK1 Gene
Proteins for SRPK1 Gene
-
Protein details for SRPK1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96SB4-SRPK1_HUMAN
- Recommended name:
- SRSF protein kinase 1
- Protein Accession:
- Q96SB4
- B4DS61
- Q12890
- Q5R364
- Q5R365
- Q8IY12
Protein attributes for SRPK1 Gene
- Size:
- 655 amino acids
- Molecular mass:
- 74325 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Monomer. Isoform 2 is found in a multisubunit complex containing seven proteins, named toposome, which separates entangled circular chromatin DNA during chromosome segregation. Isoform 2 interacts with HHV-1 ICP27 protein. Isoform 2 interacts with DNAJC8 and AHSA1/AHA1 and this mediates formation of a complex with the Hsp70 /Hsp90 machinery. Isoform 1 is found in a complex with: DHX9, MOV10, MATR3, HNRNPU, NCL, DDX21, HSD17B4, PABPC1, HNRNPM, IGF2BP1, SYNCRIP, RPL3, VIM, YBX1, NPM1, HNRNPA2B1, HNRNPC, RPLP0, RPL7A and RALY. Isoform 2 binds to IGF2BP1, SYNCRIP, HNRNPA2B1 and HNRNPC. Isoform 1 and isoform 2 interact with SAFB which inhibits its activity. Isoform 2 interacts with SAFB2 which inhibits its activity.
- SequenceCaution:
-
- Sequence=CAI20544.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI20545.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for SRPK1 Gene
Protein Expression for SRPK1 Gene
Selected DME Specific Peptides for SRPK1 Gene
- Q96SB4:
-
- VKSAEHYTE
- DIQTRQYR
- AAEATEWQ
- HITKLKPW
- SKNKKKKLKKKQKRQAELLEKR
- DDFKISG
- FVAMKVVKSA
- KLGWGHFSTVWL
- DLGNACW
- SGSAVSTAP
- ACMAFELATGD
- EEEILGSDD
- KKDKAQR
- RDEDHIA
- CMVFEVLGHHLLKWIIKSNYQGLP
- DYCKGGY
- PKPADKM
- FNGRYHV
Post-translational modifications for SRPK1 Gene
- Ubiquitination at posLast=215215
Other Protein References for SRPK1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for SRPK1
- Novus Biologicals Antibodies for SRPK1
-
Abcam antibodies for SRPK1
- Invitrogen Antibodies for SRPK1
- antibodies-online: Search results for 121 available SRPK1 Antibodies ranked by validation data
- Compare Top SRPK1 Antibodies
-
Recommended
- 19 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 99 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 1 IHC Antibody (anti-human)
- 18 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- Search GeneTex for Antibodies for SRPK1
-
Custom Antibody ServicesProSci Antibodies for SRPK1
-
Santa Cruz Biotechnology (SCBT) Antibodies for SRPK1
- Sino Biological Antibodies for SRPK1
Protein Products
-
OriGene Purified Proteins for SRPK1
- Search Origene for MassSpec and Protein Over-expression Lysates for SRPK1
- Origene Custom Protein Services for SRPK1
- Sino Biological Recombinant Proteins for SRPK1
- Sino Biological Cell Lysates for SRPK1
- Search GeneTex for Proteins for SRPK1
-
Abcam proteins for SRPK1
Assay Products
Domains & Families for SRPK1 Gene
Gene Families for SRPK1 Gene
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for SRPK1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for SRPK1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96SB4UniProtKB/Swiss-Prot:
SRPK1_HUMAN :- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.
- Family:
-
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.
Function for SRPK1 Gene
Molecular function for SRPK1 Gene
- GENATLAS Biochemistry:
- splicing factor,RS domain protein kinase 1,highly specific for the serine/arginine repeats,modulating the affinity between RS domain containing proteins and regulating the cellular distribution of their substrates
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by phosphorylation on Ser-51 and Ser-555.
- UniProtKB/Swiss-Prot Function:
- Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activities, such as chromatin reorganization in somatic and sperm cells and cell cycle progression. Isoform 2 phosphorylates SFRS2, ZRSR2, LBR and PRM1. Isoform 2 phosphorylates SRSF1 using a directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in which the kinase and substrate dissociate after each phosphorylation event). The RS domain of SRSF1 binds first to a docking groove in the large lobe of the kinase domain of SRPK1. This induces certain structural changes in SRPK1 and/or RRM2 domain of SRSF1, allowing RRM2 to bind the kinase and initiate phosphorylation. The cycles continue for several phosphorylation steps in a processive manner (steps 1-8) until the last few phosphorylation steps (approximately steps 9-12). During that time, a mechanical stress induces the unfolding of the beta-4 motif in RRM2, which then docks at the docking groove of SRPK1. This also signals RRM2 to begin to dissociate, which facilitates SRSF1 dissociation after phosphorylation is completed. Isoform 2 can mediate hepatitis B virus (HBV) core protein phosphorylation. It plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles. Isoform 1 and isoform 2 can induce splicing of exon 10 in MAPT/TAU. The ratio of isoform 1/isoform 2 plays a decisive role in determining cell fate in K-562 leukaemic cell line: isoform 2 favors proliferation where as isoform 1 favors differentiation.
Enzyme Numbers (IUBMB) for SRPK1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000287 | magnesium ion binding | IDA | 11509566 |
GO:0003723 | RNA binding | IDA,HDA | 22681889 |
GO:0004672 | protein kinase activity | TAS,IEA | 8208298 |
GO:0004674 | protein serine/threonine kinase activity | IDA,IEA | 9237760 |
GO:0005515 | protein binding | IPI | 9237760 |
Phenotypes for SRPK1 Gene
- GenomeRNAi human phenotypes for SRPK1:
-
- Increased vaccinia virus (VACV) infection
- Decreased viability in esophageal squamous lineage
- Decreased ionizing radiation sensitivity
- Dynamic nuclei (hole, folded or small irregular)
- Increased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased homologous recombination repair frequency
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Decreased Hepatitis C virus replication
- Increased cell viability after pRB stimulation
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for SRPK1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for SRPK1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SRPK1 gene
- Search ViGene Biosciences for SRPK1
CRISPR Products
-
OriGene CRISPR knockouts for SRPK1
- genomics-online: gRNA clones - Search results for available SRPK1 gene related products
- Applied Biological Materials CRISPR for SRPK1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SRPK1
- GenScript: Design CRISPR guide RNA sequences for SRPK1
miRNA for SRPK1 Gene
- miRTarBase miRNAs that target SRPK1
-
- hsa-mir-93-5p (MIRT028016)
- hsa-mir-16-5p (MIRT031711)
- hsa-mir-652-3p (MIRT039559)
- hsa-mir-186-5p (MIRT045199)
- hsa-mir-99a-5p (MIRT048634)
- hsa-mir-95-5p (MIRT100521)
- hsa-mir-3926 (MIRT441787)
- hsa-mir-3922-5p (MIRT441788)
- hsa-mir-4753-5p (MIRT441789)
- hsa-mir-7158-5p (MIRT505508)
- hsa-mir-6881-5p (MIRT505509)
- hsa-mir-6890-5p (MIRT505510)
- hsa-mir-7851-3p (MIRT505511)
- hsa-mir-619-3p (MIRT505512)
- hsa-mir-4802-3p (MIRT505513)
- hsa-mir-942-3p (MIRT505514)
- hsa-mir-6796-3p (MIRT505515)
- hsa-mir-99b-3p (MIRT505516)
- hsa-mir-99a-3p (MIRT505517)
- hsa-mir-548m (MIRT505518)
- hsa-mir-376a-5p (MIRT534069)
- hsa-mir-376a-2-5p (MIRT534070)
- hsa-mir-1976 (MIRT534071)
- hsa-mir-3653-5p (MIRT534072)
- hsa-mir-3973 (MIRT534073)
- hsa-mir-1252-3p (MIRT534074)
- hsa-mir-6077 (MIRT572702)
- hsa-mir-7-5p (MIRT572703)
- hsa-mir-6882-3p (MIRT572704)
- hsa-mir-139-5p (MIRT572705)
- hsa-mir-22-3p (MIRT572706)
- hsa-mir-3156-5p (MIRT572707)
- hsa-mir-195-5p (MIRT726453)
- hsa-mir-15b-5p (MIRT726454)
- hsa-mir-15a-5p (MIRT726455)
miRNA Products
- Search ViGene Biosciences for SRPK1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SRPK1
- Browse OriGene Inhibitory RNA Products For SRPK1
- genomics-online: shRNA clones - Search results for available SRPK1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SRPK1 gene
Clone Products
- Sino Biological Human cDNA Clone for SRPK1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SRPK1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SRPK1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for SRPK1
- genomics-online: cdna clones - Search results for available SRPK1 gene related products
- orf clones - Search results for available SRPK1 gene related products
- Applied Biological Materials Clones for SRPK1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for SRPK1
-
ViGene Biosciences adenoviral particle packaged cDNA for SRPK1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SRPK1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SRPK1 gene
No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SRPK1 Gene
Localization for SRPK1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SRPK1 Gene
- Isoform 2: Cytoplasm. Nucleus. Nucleus matrix. Microsome. Note=Shuttles between the nucleus and the cytoplasm. Inhibition of the Hsp90 ATPase activity, osmotic stress and interaction with HHV-1 ICP27 protein can induce its translocation to the nucleus. KAT5/TIP60 inhibits its nuclear translocation.
- Isoform 1: Cytoplasm. Nucleus matrix. Microsome. Note=Mainly localized in the microsomal fraction and the cytoplasm, and to a lesser extent in the nuclear matrix.
- Cytosol (3)
- Nucleus (3)
- Plasma membrane (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | TAS,IDA | 11509566 |
GO:0005737 | cytoplasm | IEA,IDA | 11509566 |
GO:0005783 | endoplasmic reticulum | IEA | -- |
GO:0005829 | cytosol | IDA | -- |
GO:0005886 | plasma membrane | IDA | -- |
Pathways & Interactions for SRPK1 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Influenza A | ||
2 | mRNA Splicing - Major Pathway |
.41
|
Pathways by source for SRPK1 Gene
1 BioSystems pathway for SRPK1 Gene
1 KEGG pathway for SRPK1 Gene
Interacting Proteins for SRPK1 Gene
SIGNOR curated interactions for SRPK1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000245 | spliceosomal complex assembly | IBA | -- |
GO:0006397 | mRNA processing | IEA | -- |
GO:0006468 | protein phosphorylation | IEA,IDA | 9237760 |
GO:0007059 | chromosome segregation | IEA,IDA | 15034300 |
GO:0008380 | RNA splicing | TAS | 8208298 |
Drugs & Compounds for SRPK1 Gene
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Full agonist, Agonist | 58-64-0 |
|
(1) ApexBio Compounds for SRPK1 Gene
Compound | Action | Cas Number |
---|---|---|
SRPIN340 | Selective SRPK1 inhibitor | 218156-96-8 |
Transcripts for SRPK1 Gene
mRNA/cDNA for SRPK1 Gene
- (1) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (276) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SRPK1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SRPK1
- genomics-online: gRNA clones - Search results for available SRPK1 gene related products
- Applied Biological Materials CRISPR for SRPK1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SRPK1
- GenScript: Design CRISPR guide RNA sequences for SRPK1
miRNA Products
- Search ViGene Biosciences for SRPK1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SRPK1
- Browse OriGene Inhibitory RNA Products For SRPK1
- genomics-online: shRNA clones - Search results for available SRPK1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SRPK1 gene
Clone Products
- Sino Biological Human cDNA Clone for SRPK1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SRPK1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SRPK1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for SRPK1
- genomics-online: cdna clones - Search results for available SRPK1 gene related products
- orf clones - Search results for available SRPK1 gene related products
- Applied Biological Materials Clones for SRPK1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 |
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SP1: | - | - | |||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||||||||||||||||
SP6: |
Expression for SRPK1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
- Kidney (Urinary System)
- Thymus (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for SRPK1 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SRPK1 Gene
NURSA nuclear receptor signaling pathways regulating expression of SRPK1 Gene:
SRPK1SOURCE GeneReport for Unigene cluster for SRPK1 Gene:
Hs.443861mRNA Expression by UniProt/SwissProt for SRPK1 Gene:
Q96SB4-SRPK1_HUMANEvidence on tissue expression from TISSUES for SRPK1 Gene
- Nervous system(4.8)
- Liver(4.3)
- Intestine(2)
Primer Products
-
OriGene qPCR primer pairs for SRPK1
-
OriGene qPCR primer pairs and template standards for SRPK1
- genomics-online: primer clones - Search results for available SRPK1 gene related products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SRPK1 Gene
Orthologs for SRPK1 Gene
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | SRPK1 34 33 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | SRPK1 34 33 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | SRPK1 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Srpk1 16 34 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-7265 34 |
|
OneToOne | |
rat (Rattus norvegicus) |
Mammalia | Srpk1 33 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
-- 34 |
|
OneToMany | |||
chicken (Gallus gallus) |
Aves | SRPK1 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | SRPK1 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | srpk1 33 |
|
||
Str.7492 33 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.24774 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | srpk1a 33 34 |
|
||
srpk1b 34 |
|
OneToMany | |||
wufc06h03 33 |
|
||||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005322 33 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | BEST:CK01209 35 |
|
|
|
SRPK 35 33 34 |
|
||||
CG8565 35 |
|
|
|||
worm (Caenorhabditis elegans) |
Secernentea | spk-1 34 |
|
OneToMany | |
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SKY1 34 |
|
OneToMany | |
thale cress (Arabidopsis thaliana) |
eudicotyledons | SRPK4 33 |
|
||
Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.7716 33 |
|
||
rice (Oryza sativa) |
Liliopsida | Os03g0748400 33 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for SRPK1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for SRPK1 Gene
(3) SIMAP similar genes for SRPK1 Gene using alignment to 9 proteins:
Pseudogenes.org Pseudogenes for SRPK1 Gene
Variants for SRPK1 Gene
SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000018594 | -- | 35,854,553(-) | C/T | intron_variant | |
rs1000067290 | -- | 35,867,085(-) | G/A | intron_variant | |
rs1000085400 | -- | 35,905,575(-) | A/G | intron_variant | |
rs1000155573 | -- | 35,850,058(-) | G/T | intron_variant | |
rs1000171513 | -- | 35,851,504(-) | A/G | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2676075 | CNV | deletion | 23128226 |
esv2731915 | CNV | deletion | 23290073 |
esv2759420 | CNV | gain | 17122850 |
esv3608689 | CNV | gain | 21293372 |
esv3608695 | CNV | loss | 21293372 |
esv3890842 | CNV | gain | 25118596 |
nsv1114795 | CNV | deletion | 24896259 |
nsv1117614 | CNV | deletion | 24896259 |
nsv428143 | CNV | gain | 18775914 |
nsv477287 | CNV | novel sequence insertion | 20440878 |
nsv821646 | CNV | loss | 15273396 |
nsv965720 | CNV | duplication | 23825009 |
Additional Variant Information for SRPK1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SRPK1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRPK1 Gene
Disorders for SRPK1 Gene
Additional Disease Information for SRPK1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for SRPK1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRPK1 Gene
Publications for SRPK1 Gene
- Regulation of SR protein phosphorylation and alternative splicing by modulating kinetic interactions of SRPK1 with molecular chaperones. (PMID: 19240134) Zhong XY … Fu XD (Genes & development 2009) 3 4 22 58
- Regiospecific phosphorylation control of the SR protein ASF/SF2 by SRPK1. (PMID: 19477182) Ma CT … Adams JA (Journal of molecular biology 2009) 3 4 22 58
- The enzymatic activity of SR protein kinases 1 and 1a is negatively affected by interaction with scaffold attachment factors B1 and 2. (PMID: 19674106) Tsianou D … Georgatsou E (The FEBS journal 2009) 3 4 22 58
- Ordered multi-site phosphorylation of the splicing factor ASF/SF2 by SRPK1. (PMID: 18155240) Ma CT … Adams JA (Journal of molecular biology 2008) 3 4 22 58
- A sliding docking interaction is essential for sequential and processive phosphorylation of an SR protein by SRPK1. (PMID: 18342604) Ngo JC … Ghosh G (Molecular cell 2008) 3 4 22 58
Products for SRPK1 Gene
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- Invitrogen Antibodies for SRPK1
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- Mammalian expression: PiggyBac
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- antibodies-online: Search results for 121 available SRPK1 Antibodies ranked by validation data
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Sources for SRPK1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
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- (7) GeneLoc
- (8) Gene Wiki
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- (36) SGD
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- (39) Pseudogene
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- (42) GenAtlas
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- (49) GenBank
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- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
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- (58) PubMed
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- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
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- (80) miRTarBase
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