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Aliases for SRP9 Gene

Aliases for SRP9 Gene

  • Signal Recognition Particle 9 2 3 5
  • Signal Recognition Particle 9kDa 2 3
  • Signal Recognition Particle 9 KDa Protein 3
  • Signal Recognition Particle 9kD 3
  • ALURBP 3

External Ids for SRP9 Gene

Previous GeneCards Identifiers for SRP9 Gene

  • GC01P224447
  • GC01P221782
  • GC01P222372
  • GC01P222940
  • GC01P222272
  • GC01P224034
  • GC01P225965
  • GC01P196483

Summaries for SRP9 Gene

GeneCards Summary for SRP9 Gene

SRP9 (Signal Recognition Particle 9) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Protein export. GO annotations related to this gene include RNA binding and signal recognition particle binding.

UniProtKB/Swiss-Prot for SRP9 Gene

  • Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.

Additional gene information for SRP9 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRP9 Gene

Genomics for SRP9 Gene

Regulatory Elements for SRP9 Gene

Enhancers for SRP9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H225822 1.8 FANTOM5 Ensembl ENCODE dbSUPER 5.7 +47.6 47560 5 FOXA2 MLX ARID4B YY1 TCF12 ZNF121 GLIS2 GATA2 SP5 MXD4 EPHX1 TMEM63A LEFTY1 ENSG00000255835 PYCR2 ENSG00000248322 LEFTY2 LEFTY3 SRP9 GC01P225813
GH01H225809 1.6 Ensembl ENCODE dbSUPER 5.4 +34.5 34527 5 HDGF FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ENSG00000255835 PYCR2 LEFTY2 ENSG00000248322 LEFTY3 EPHX1 SRP9 ITPKB GC01P225813 ENSG00000242861
GH01H226247 0.4 FANTOM5 2.9 +469.7 469718 0 LIN9 PARP1 PYCR2 SRP9 H3F3A GC01P226243 GC01P226285
GH01H225770 1.6 Ensembl ENCODE dbSUPER 0.7 -5.0 -4958 4 HDGF FOXA2 ARID4B SIN3A ZNF2 YY1 CBX5 ZNF416 ZNF143 DEK ACBD3 LEFTY1 ACBD3-AS1 ENAH SRP9 RNU6-1304P
GH01H225776 1.2 ENCODE 0.7 +0.4 436 4 DMAP1 YY1 ZNF416 ZNF143 SP3 NFYC ZNF610 GLIS1 NBN KDM1A ACBD3 ACBD3-AS1 LINC01703 LEFTY1 LEFTY3 EPHX1 SRP9
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SRP9 on UCSC Golden Path with GeneCards custom track

Promoters for SRP9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000021017 387 2401 ZFP64 DMAP1 YY1 ZNF416 ZNF143 SP3 NFYC ZNF610 GLIS1 NBN

Genomic Location for SRP9 Gene

Chromosome:
1
Start:
225,777,813 bp from pter
End:
225,790,466 bp from pter
Size:
12,654 bases
Orientation:
Plus strand

Genomic View for SRP9 Gene

Genes around SRP9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRP9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRP9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRP9 Gene

Proteins for SRP9 Gene

  • Protein details for SRP9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49458-SRP09_HUMAN
    Recommended name:
    Signal recognition particle 9 kDa protein
    Protein Accession:
    P49458
    Secondary Accessions:
    • A8K0N0
    • Q6NVX0
    • Q8WTW0

    Protein attributes for SRP9 Gene

    Size:
    86 amino acids
    Molecular mass:
    10112 Da
    Quaternary structure:
    • Signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.

    Three dimensional structures from OCA and Proteopedia for SRP9 Gene

    Alternative splice isoforms for SRP9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRP9 Gene

Post-translational modifications for SRP9 Gene

  • Ubiquitination at Lys16, posLast=6464, and Lys76
  • Modification sites at PhosphoSitePlus

Other Protein References for SRP9 Gene

No data available for DME Specific Peptides for SRP9 Gene

Domains & Families for SRP9 Gene

Gene Families for SRP9 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Suggested Antigen Peptide Sequences for SRP9 Gene

Graphical View of Domain Structure for InterPro Entry

P49458

UniProtKB/Swiss-Prot:

SRP09_HUMAN :
  • Belongs to the SRP9 family.
Family:
  • Belongs to the SRP9 family.
genes like me logo Genes that share domains with SRP9: view

Function for SRP9 Gene

Molecular function for SRP9 Gene

UniProtKB/Swiss-Prot Function:
Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.

Phenotypes From GWAS Catalog for SRP9 Gene

Gene Ontology (GO) - Molecular Function for SRP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 7730321
GO:0005047 signal recognition particle binding TAS 7730321
GO:0005515 protein binding IPI 24965446
GO:0008312 7S RNA binding IEA --
genes like me logo Genes that share ontologies with SRP9: view
genes like me logo Genes that share phenotypes with SRP9: view

Animal Models for SRP9 Gene

MGI Knock Outs for SRP9:
  • Srp9 tm1.1(KOMP)Vlcg

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SRP9
  • Applied Biological Materials Clones for SRP9
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SRP9 Gene

Localization for SRP9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRP9 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRP9 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
cytosol 5
nucleus 1

Gene Ontology (GO) - Cellular Components for SRP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005785 signal recognition particle receptor complex TAS 7730321
GO:0005786 signal recognition particle, endoplasmic reticulum targeting NAS 17154533
GO:0005829 cytosol TAS --
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with SRP9: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SRP9 Gene

Pathways & Interactions for SRP9 Gene

genes like me logo Genes that share pathways with SRP9: view

Pathways by source for SRP9 Gene

Gene Ontology (GO) - Biological Process for SRP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS,IEA --
GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation IBA --
GO:0045900 negative regulation of translational elongation IEA --
genes like me logo Genes that share ontologies with SRP9: view

No data available for SIGNOR curated interactions for SRP9 Gene

Drugs & Compounds for SRP9 Gene

No Compound Related Data Available

Transcripts for SRP9 Gene

Unigene Clusters for SRP9 Gene

Signal recognition particle 9kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SRP9
  • Applied Biological Materials Clones for SRP9
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SRP9 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: -
SP2: - - -
SP3: -

Relevant External Links for SRP9 Gene

GeneLoc Exon Structure for
SRP9
ECgene alternative splicing isoforms for
SRP9

Expression for SRP9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SRP9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SRP9 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SRP9 Gene



Protein tissue co-expression partners for SRP9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SRP9 Gene:

SRP9

SOURCE GeneReport for Unigene cluster for SRP9 Gene:

Hs.511425

Evidence on tissue expression from TISSUES for SRP9 Gene

  • Nervous system(5)
  • Liver(4.8)
  • Skin(4.8)
  • Kidney(4.3)
  • Bone marrow(4.2)
  • Lung(4.2)
  • Pancreas(3.9)
  • Blood(2.6)
  • Eye(2.6)
  • Intestine(2.5)
  • Muscle(2.5)
  • Heart(2.4)
  • Spleen(2.4)
  • Bone(2.1)
genes like me logo Genes that share expression patterns with SRP9: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRP9 Gene

Orthologs for SRP9 Gene

This gene was present in the common ancestor of animals.

Orthologs for SRP9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRP9 33 34
  • 100 (n)
dog
(Canis familiaris)
Mammalia SRP9 33 34
  • 94.19 (n)
oppossum
(Monodelphis domestica)
Mammalia SRP9 34
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SRP9 34
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRP9 34
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srp9 33 16 34
  • 88.37 (n)
rat
(Rattus norvegicus)
Mammalia Srp9 33
  • 86.82 (n)
chicken
(Gallus gallus)
Aves SRP9 33 34
  • 83.72 (n)
lizard
(Anolis carolinensis)
Reptilia SRP9 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia srp9 33
  • 81.4 (n)
Str.17011 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.5226 33
zebrafish
(Danio rerio)
Actinopterygii srp9 33 34
  • 71.32 (n)
zgc56668 33
fruit fly
(Drosophila melanogaster)
Insecta Srp9 34
  • 40 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ZK512.4 34
  • 51 (a)
OneToOne
Species where no ortholog for SRP9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRP9 Gene

ENSEMBL:
Gene Tree for SRP9 (if available)
TreeFam:
Gene Tree for SRP9 (if available)

Paralogs for SRP9 Gene

(1) SIMAP similar genes for SRP9 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SRP9: view

No data available for Paralogs for SRP9 Gene

Variants for SRP9 Gene

Sequence variations from dbSNP and Humsavar for SRP9 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000465567 -- 225,781,790(+) TTAGT(A/G)TATTT intron-variant
rs1000484206 -- 225,785,176(+) AGTGA(G/T)TCTCC intron-variant
rs1000793867 -- 225,781,498(+) GAGTT(A/C)AAGCG intron-variant
rs1000955648 -- 225,778,153(+) TTCTG(C/T)TCTCT intron-variant
rs1001085638 -- 225,783,585(+) TTTAA(C/T)AAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRP9 Gene

Variant ID Type Subtype PubMed ID
nsv1144438 CNV deletion 24896259
nsv524126 CNV gain 19592680
nsv832736 CNV loss 17160897
nsv945326 CNV duplication 23825009

Variation tolerance for SRP9 Gene

Residual Variation Intolerance Score: 55.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.14; 3.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRP9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRP9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRP9 Gene

Disorders for SRP9 Gene

Relevant External Links for SRP9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRP9

No disorders were found for SRP9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRP9 Gene

Publications for SRP9 Gene

  1. Structure and assembly of the Alu domain of the mammalian signal recognition particle. (PMID: 11089964) Weichenrieder O … Cusack S (Nature 2000) 3 4 22 60
  2. Human signal recognition particle (SRP) Alu-associated protein also binds Alu interspersed repeat sequence RNAs. Characterization of human SRP9. (PMID: 7730321) Hsu K … Maraia RJ (The Journal of biological chemistry 1995) 2 3 4 60
  3. Proteomic expression analysis of surgical human colorectal cancer tissues: up-regulation of PSB7, PRDX1, and SRP9 and hypoxic adaptation in cancer. (PMID: 18549262) Rho JH … Roehrl MH (Journal of proteome research 2008) 3 22 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Assembly of the Alu domain of the signal recognition particle (SRP): dimerization of the two protein components is required for efficient binding to SRP RNA. (PMID: 2153922) Strub K … Walter P (Molecular and cellular biology 1990) 3 22 60

Products for SRP9 Gene

Sources for SRP9 Gene

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