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SRP9 Gene

protein-coding   GIFtS: 55
GCID: GC01P225965

Signal Recognition Particle 9kDa

(Previous name: signal recognition particle 9kD)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Signal Recognition Particle 9kDa1 2
Signal Recognition Particle 9kD1
ALURBP2
Signal Recognition Particle 9 KDa Protein2

External Ids:    HGNC: 113041   Entrez Gene: 67262   Ensembl: ENSG000001437427   OMIM: 6007075   UniProtKB: P494583   
ORGUL members:         

Export aliases for SRP9 gene to outside databases

Previous GC identifers: GC01P224447 GC01P221782 GC01P222372 GC01P222940 GC01P222272 GC01P224034 GC01P196483


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SRP9 Gene:
SRP9 (signal recognition particle 9kDa) is a protein-coding gene. Diseases associated with SRP9 include sost-related sclerosing bone dysplasia, and colorectal cancer. GO annotations related to this gene include RNA binding and signal recognition particle binding.

UniProtKB/Swiss-Prot: SRP09_HUMAN, P49458
Function: Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough
endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the
elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_167186.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SRP9 gene promoter:
         Spz1   STAT1   NF-1   AML1a   STAT1beta   LCR-F1   STAT1alpha   AREB6   STAT3   Chx10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSRP9 promoter sequence
   Search Chromatin IP Primers for SRP9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SRP9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.12   Ensembl cytogenetic band:  1q42.12   HGNC cytogenetic band: 1q42.12

SRP9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRP9 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P225965:  view genomic region     (about GC identifiers)

Start:
225,965,515 bp from pter      End:
225,978,168 bp from pter
Size:
12,654 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SRP09_HUMAN, P49458 (See protein sequence)
Recommended Name: Signal recognition particle 9 kDa protein  
Size: 86 amino acids; 10112 Da
Subunit: Signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits:
SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9
3 PDB 3D structures from and Proteopedia for SRP9:
1E8O (3D)        1E8S (3D)        1RY1 (3D)    
Secondary accessions: A8K0N0 Q6NVX0 Q8WTW0
Alternative splicing: 2 isoforms:  P49458-1   P49458-2   (Ref.5 (AAH21995) sequence is in conflict in position: 64:I->M)

Explore the universe of human proteins at neXtProt for SRP9: NX_P49458

Explore proteomics data for SRP9 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys16, Lys24, Lys52, Lys61, Lys64, Lys76
  • Modification sites at PhosphoSitePlus

  • See SRP9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001123912.1  NP_003124.1  

    ENSEMBL proteins: 
     ENSP00000305230   ENSP00000355804   ENSP00000355803  
    Reactome Protein details: P49458

    SRP9 Human Recombinant Protein Products:

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    Novus Biologicals SRP9 Lysate
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    Cloud-Clone Corp. Proteins for SRP9

    SRP9 Antibody Products:

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    SRP9 Assay Products:

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    Cloud-Clone Corp. ELISAs for SRP9
    Cloud-Clone Corp. CLIAs for SRP9


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR008832 Signal_recog_particle_SRP9
     IPR009018 Signal_recog_particle_SRP9/14

    Graphical View of Domain Structure for InterPro Entry P49458

    ProtoNet protein and cluster: P49458

    1 Blocks protein domain: IPB008832 Signal recognition particle 9 kDa

    UniProtKB/Swiss-Prot: SRP09_HUMAN, P49458
    Similarity: Belongs to the SRP9 family


    SRP9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRP09_HUMAN, P49458
    Function: Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough
    endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the
    elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS7730321
    GO:0005047signal recognition particle binding TAS7730321
    GO:00083127S RNA binding IEA--
         
    SRP9 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SRP9
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SRP9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SRP9
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SRP9

    miRNA
    Products:
        
    miRTarBase miRNAs that target SRP9:
    hsa-mir-421 (MIRT039405), hsa-mir-196a-5p (MIRT048202), hsa-mir-877-3p (MIRT036946), hsa-mir-26b-5p (MIRT029418), hsa-mir-18a-3p (MIRT040748)

    Block miRNA regulation of human, mouse, rat SRP9 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SRP9 (see all 9):
    hsa-miR-607 hsa-miR-1237 hsa-miR-4251 hsa-miR-578 hsa-miR-146a* hsa-miR-494 hsa-miR-129-3p hsa-miR-3145-3p
    SwitchGear 3'UTR luciferase reporter plasmidSRP9 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SRP9
    Predesigned siRNA for gene silencing in human, mouse, rat SRP9

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): SRP9 (NM_001130440)
    Sino Biological Human cDNA Clone for SRP9
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRP9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRP9

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SRP9 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRP9


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SRP09_HUMAN, P49458: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    endoplasmic reticulum4
    extracellular2
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005785signal recognition particle receptor complex TAS7730321
    GO:0005786signal recognition particle, endoplasmic reticulum targeting NAS17154533
    GO:0005829cytosol TAS--
    GO:0048500signal recognition particle ----

    SRP9 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SRP9 About    
    See pathways by source

    SuperPathContained pathways About
    1Influenza Viral RNA Transcription and Replication
    SRP-dependent cotranslational protein targeting to membrane0.83
    Translation0.82
    2Gene Expression
    Gene Expression0.40
    3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    4Protein export
    Protein export

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for SRP9
        SRP-dependent cotranslational protein targeting to membrane


    1 Kegg Pathway  (Kegg details for SRP9):
        Protein export


    SRP9 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SRP9
    Interactions:

        GeneGlobe Interaction Network for SRP9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for SRP9 (P494582, 3 ENSP000003052304) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LIN54Q6MZP73, ENSP000003419474I2D: score=1 STRING: ENSP00000341947
    MAP1LC3AQ9H4923, ENSP000003639704I2D: score=1 STRING: ENSP00000363970
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    SRP14P371083, ENSP000002678844I2D: score=3 STRING: ENSP00000267884
    EPB41P111713, ENSP000002901004I2D: score=1 STRING: ENSP00000290100
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation TAS--
    GO:0006614SRP-dependent cotranslational protein targeting to membrane TAS--
    GO:0010467gene expression TAS--
    GO:0044267cellular protein metabolic process TAS--
    GO:0045900negative regulation of translational elongation IEA--

    SRP9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SRP9 (SRP09)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SRP9 gene (2 alternative transcripts): 
    NM_001130440.1  NM_003133.5  

    Unigene Cluster for SRP9:

    Signal recognition particle 9kDa
    Hs.511425  [show with all ESTs]
    Unigene Representative Sequence: BC064351
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000304786(uc001hpf.4 uc001hpg.3 uc001hpi.4) ENST00000366839(uc001hph.3)
    ENST00000366838
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SRP9 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SRP9 (see all 9):
    hsa-miR-607 hsa-miR-1237 hsa-miR-4251 hsa-miR-578 hsa-miR-146a* hsa-miR-494 hsa-miR-129-3p hsa-miR-3145-3p
    SwitchGear 3'UTR luciferase reporter plasmidSRP9 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SRP9
    Predesigned siRNA for gene silencing in human, mouse, rat SRP9
    Clone
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    OriGene clones in human, mouse for SRP9 (see all 13)
    OriGene ORF clones in mouse, rat for SRP9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SRP9 (NM_001130440)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRP9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRP9
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SRP9
    OriGene qSTAR qPCR primer pairs in human, mouse for SRP9
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat SRP9
      QuantiTect SYBR Green Assays in human, mouse, rat SRP9
      QuantiFast Probe-based Assays in human, mouse, rat SRP9

    Additional mRNA sequence: 

    AF070649.1 AK289595.1 AL050363.1 BC008443.1 BC015094.1 BC017414.1 BC022415.1 BC045603.1 
    BC064351.1 BC066957.1 BC106005.1 U20998.1 

    Selected DOTS entries (see all 54):

    DT.100809332  DT.92472791  DT.449332  DT.100888897  DT.92472828  DT.100888900  DT.100888882  DT.100033394 
    DT.100045223  DT.92472821  DT.95242459  DT.92472835  DT.100888844  DT.100888888  DT.100888845  DT.121247945 
    DT.100888881  DT.100888849  DT.121247944  DT.121385854  DT.100888878  DT.100034427  DT.95242347  DT.100888865 

    Selected AceView cDNA sequences (see all 2079):

    BG939980 AI127584 BP381045 BU170371 BI224367 BM565507 BF941313 BP338632 
    BM800692 AI889123 T35675 AA614798 BM674039 AA169489 BX364710 AA679839 
    BM314765 AV718048 AI753796 CB157982 BE465664 BM875472 AW673653 CR596336 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SRP9    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
    SP1:                          -                     
    SP2:                    -     -     -               
    SP3:                    -                           


    ECgene alternative splicing isoforms for SRP9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SRP9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCAGAGAG
    SRP9 Expression
    About this image

    SRP9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SRP9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.511425
        Custom PCR Arrays for SRP9
    Primer
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    OriGene qPCR primer pairs and template standards for SRP9
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    QuantiFast Probe-based Assays in human, mouse, rat SRP9
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRP9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SRP9 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srp91 , 5 signal recognition particle 91, 5 88.37(n)1
    93.02(a)1
      1 (84.93 cM)5
    270581  NM_012058.31  NP_036188.11 
     1821247375 
    chicken
    (Gallus gallus)
    Aves SRP91 signal recognition particle 9kDa 83.72(n)
    82.56(a)
      770243  NM_001097536.1  NP_001091005.1 
    lizard
    (Anolis carolinensis)
    Reptilia SRP96
    signal recognition particle 9kDa
    84(a)
    1 ↔ 1
    1(251749426-251754861)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.52262 Xenopus laevis transcribed sequence with moderate similarity more 80.42(n)    BJ613515.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc566682 similar to signal recognition particle 9kDa 73.13(n)   394071  BC049522.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Srp96
    Signal recognition particle protein 9
    40(a)
    1 ↔ 1
    3L(7929473-7930358)
    worm
    (Caenorhabditis elegans)
    Secernentea ZK512.46
    Protein ZK512.4 (ZK512.4) mRNA, complete cds
    51(a)
    1 ↔ 1
    III(9145325-9145976) WBGene00013984


    ENSEMBL Gene Tree for SRP9 (if available)
    TreeFam Gene Tree for SRP9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SRP9 gene
    1 SIMAP similar gene for SRP9 using alignment to 3 protein entries:     SRP09_HUMAN (see all proteins):
    DKFZp564M2223

    SRP9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SRP9 (see all 353)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1824392301,2
    --225963522(+) GCCCTC/GTCTGC 2 -- us2k10--------
    rs1114529761,2
    C--225963559(+) CCTCAACAC/-  
            
    ACACA
    2 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs46536721,2
    A--225963578(+) acacaC/Gacaca 2 -- us2k10--------
    rs1998931121,2
    --225963578(+) CACAC-/AGACACA 2 -- us2k10--------
    rs38202271,2
    C,F--225963580(+) ACACAG/CACACA 2 -- us2k13Minor allele frequency- C:0.50WA NA CSA 6
    rs1469186941,2
    C--225963580(+) cacac-/AGacaca 2 -- us2k10--------
    rs339445131,2
    C--225963581(+) ACACA-/AGCACAC 2 -- us2k10--------
    rs38202281,2
    C--225963591(+) CACACG/ATGTCT 2 -- us2k11Minor allele frequency- A:0.00NA 2
    rs1396402551,2
    C--225963591(+) CACAC-/GTGTCTC 2 -- us2k10--------
    rs38202291,2
    C--225963592(+) ACACGT/CGTCTC 2 -- us2k11Minor allele frequency- C:0.00NA 2

    HapMap Linkage Disequilibrium report for SRP9 (225965515 - 225978168 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SRP9:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832736CNV Loss17160897
    nsv524126CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SRP9
    DNA2.0 Custom Variant and Variant Library Synthesis for SRP9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600707    OMIM disorders: --

    3 diseases for SRP9:    
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    sost-related sclerosing bone dysplasia    colorectal cancer    hiv-1

    1 disease from the University of Copenhagen DISEASES database for SRP9:
    SOST-related sclerosing bone dysplasia

    SRP9 for disorders           About GeneDecksing


    Export disorders for SRP9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SRP9 gene, integrated from 10 sources (see all 52):
    (articles sorted by number of sources associating them with SRP9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human signal recognition particle (SRP) Alu-associated protein also binds Alu interspersed repeat sequence RNAs. Characterization of human SRP9. (PubMed id 7730321)1, 2, 3 Hsu K.... Maraia R.J. (J. Biol. Chem. 1995)
    2. Structure and assembly of the Alu domain of the mammalian signal recognition particle. (PubMed id 11089964)1, 2, 9 Weichenrieder O.... Cusack S. (Nature 2000)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Proteomic expression analysis of surgical human colorectal cancer tissues: up-regulation of PSB7, PRDX1, and SRP9 and hypoxic adaptation in cancer. (PubMed id 18549262)1, 9 Rho J.H.... Roehrl M.H. (J. Proteome Res. 2008)
    5. Assembly of the Alu domain of the signal recognition particle (SRP): dimerization of the two protein components is required for efficient binding to SRP RNA. (PubMed id 2153922)1, 9 Strub K. and Walter P. (Mol. Cell. Biol. 1990)
    6. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    7. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1 Cloutier P.... Coulombe B. (PLoS Genet. 2013)
    8. Cleavage and polyadenylation specificity factor 1 (CPSF1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6. (PubMed id 23151878)1 Evsyukova I....Garcia-Blanco M.A. (RNA 2013)
    9. Implication of the SMN complex in the biogenesis and steady state level of the signal recognition particle. (PubMed id 23221635)1 Piazzon N....Massenet S. (Nucleic Acids Res. 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6726 HGNC: 11304 AceView: SRP9 Ensembl:ENSG00000143742 euGenes: HUgn6726
    ECgene: SRP9 Kegg: 6726 H-InvDB: SRP9

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SRP9 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Signal-recognition_particle

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SRP9 gene:
    Search GeneIP for patents involving SRP9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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