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Aliases for SRP9 Gene

Aliases for SRP9 Gene

  • Signal Recognition Particle 9kDa 2 3
  • Signal Recognition Particle 9kD 2 3
  • Signal Recognition Particle 9 KDa Protein 3
  • ALURBP 3

External Ids for SRP9 Gene

Summaries for SRP9 Gene

GeneCards Summary for SRP9 Gene

SRP9 (Signal Recognition Particle 9kDa) is a Protein Coding gene. Diseases associated with SRP9 include sost-related sclerosing bone dysplasia. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Gene Expression. GO annotations related to this gene include RNA binding and signal recognition particle binding.

UniProtKB/Swiss-Prot for SRP9 Gene

  • Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRP9 Gene

Genomics for SRP9 Gene

Genomic Location for SRP9 Gene

Start:
225,777,813 bp from pter
End:
225,790,466 bp from pter
Size:
12,654 bases
Orientation:
Plus strand

Genomic View for SRP9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SRP9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRP9 Gene

Regulatory Elements for SRP9 Gene

Proteins for SRP9 Gene

  • Protein details for SRP9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49458-SRP09_HUMAN
    Recommended name:
    Signal recognition particle 9 kDa protein
    Protein Accession:
    P49458
    Secondary Accessions:
    • A8K0N0
    • Q6NVX0
    • Q8WTW0

    Protein attributes for SRP9 Gene

    Size:
    86 amino acids
    Molecular mass:
    10112 Da
    Quaternary structure:
    • Signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.

    Three dimensional structures from OCA and Proteopedia for SRP9 Gene

    Alternative splice isoforms for SRP9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRP9 Gene

Proteomics data for SRP9 Gene at MOPED

Post-translational modifications for SRP9 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys16, Lys24, Lys52, Lys61, Lys64, and Lys76

Other Protein References for SRP9 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SRP9 Gene

Domains for SRP9 Gene

Protein Domains for SRP9 Gene

UniProtKB/Swiss-Prot:

SRP09_HUMAN
Family:
  • Belongs to the SRP9 family.:
    • P49458
genes like me logo Genes that share domains with SRP9: view

No data available for Gene Families for SRP9 Gene

Function for SRP9 Gene

Molecular function for SRP9 Gene

UniProtKB/Swiss-Prot Function: Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding

Gene Ontology (GO) - Molecular Function for SRP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 7730321
GO:0005047 signal recognition particle binding TAS 7730321
GO:0008312 7S RNA binding IEA --
genes like me logo Genes that share ontologies with SRP9: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SRP9 Gene

Localization for SRP9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRP9 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRP9 Gene COMPARTMENTS Subcellular localization image for SRP9 gene
Compartment Confidence
cytosol 4
endoplasmic reticulum 4
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for SRP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005785 signal recognition particle receptor complex TAS 7730321
GO:0005786 signal recognition particle, endoplasmic reticulum targeting NAS 17154533
GO:0005829 cytosol TAS --
GO:0048500 signal recognition particle --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SRP9: view

Pathways for SRP9 Gene

genes like me logo Genes that share pathways with SRP9: view

Pathways by source for SRP9 Gene

Gene Ontology (GO) - Biological Process for SRP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
GO:0010467 gene expression TAS --
GO:0044267 cellular protein metabolic process TAS --
GO:0045900 negative regulation of translational elongation IEA --
genes like me logo Genes that share ontologies with SRP9: view

Transcripts for SRP9 Gene

Unigene Clusters for SRP9 Gene

Signal recognition particle 9kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SRP9 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: -
SP2: - - -
SP3: -

Relevant External Links for SRP9 Gene

GeneLoc Exon Structure for
SRP9
ECgene alternative splicing isoforms for
SRP9

Expression for SRP9 Gene

mRNA expression in normal human tissues for SRP9 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SRP9 Gene

SOURCE GeneReport for Unigene cluster for SRP9 Gene Hs.511425

genes like me logo Genes that share expressions with SRP9: view

Orthologs for SRP9 Gene

This gene was present in the common ancestor of animals.

Orthologs for SRP9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRP9 36
  • 100 (n)
  • 100 (a)
SRP9 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SRP9 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRP9 36
  • 94.19 (n)
  • 91.86 (a)
SRP9 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srp9 36
  • 88.37 (n)
  • 93.02 (a)
Srp9 16
Srp9 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SRP9 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRP9 37
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Srp9 36
  • 86.82 (n)
  • 90.7 (a)
chicken
(Gallus gallus)
Aves SRP9 36
  • 83.72 (n)
  • 82.56 (a)
SRP9 37
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRP9 37
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5226 36
tropical clawed frog
(Silurana tropicalis)
Amphibia srp9 36
  • 81.4 (n)
  • 81.4 (a)
Str.17011 36
zebrafish
(Danio rerio)
Actinopterygii srp9 36
  • 71.32 (n)
  • 77.91 (a)
srp9 37
  • 78 (a)
OneToOne
zgc56668 36
fruit fly
(Drosophila melanogaster)
Insecta Srp9 37
  • 40 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ZK512.4 37
  • 51 (a)
OneToOne
Species with no ortholog for SRP9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRP9 Gene

ENSEMBL:
Gene Tree for SRP9 (if available)
TreeFam:
Gene Tree for SRP9 (if available)

Paralogs for SRP9 Gene

Selected SIMAP similar genes for SRP9 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SRP9: view

No data available for Paralogs for SRP9 Gene

Variants for SRP9 Gene

Sequence variations from dbSNP and Humsavar for SRP9 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs14113 -- 225,790,305(+) TAAAT(C/G)TAATG utr-variant-3-prime
rs1050033 -- 225,790,266(+) AAGTA(C/T)GATAT utr-variant-3-prime
rs1130900 -- 225,786,879(+) GCTCT(A/G)TTGCT reference, synonymous-codon, intron-variant
rs1130901 -- 225,786,912(+) ATCAT(A/G)GCTCA reference, missense, intron-variant
rs1461957 -- 225,778,130(-) AGGGT(A/C)CATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRP9 Gene

Variant ID Type Subtype PubMed ID
nsv832736 CNV Loss 17160897
nsv524126 CNV Gain 19592680

Relevant External Links for SRP9 Gene

HapMap Linkage Disequilibrium report
SRP9

Disorders for SRP9 Gene

(1) University of Copenhagen DISEASES for SRP9 Gene

genes like me logo Genes that share disorders with SRP9: view

No data available for UniProtKB/Swiss-Prot for SRP9 Gene

Publications for SRP9 Gene

  1. Structure and assembly of the Alu domain of the mammalian signal recognition particle. (PMID: 11089964) Weichenrieder O. … Cusack S. (Nature 2000) 3 4 23
  2. Human signal recognition particle (SRP) Alu-associated protein also binds Alu interspersed repeat sequence RNAs. Characterization of human SRP9. (PMID: 7730321) Hsu K. … Maraia R.J. (J. Biol. Chem. 1995) 2 3 4
  3. Proteomic expression analysis of surgical human colorectal cancer tissues: up-regulation of PSB7, PRDX1, and SRP9 and hypoxic adaptation in cancer. (PMID: 18549262) Rho J.H. … Roehrl M.H. (J. Proteome Res. 2008) 3 23
  4. Assembly of the Alu domain of the signal recognition particle (SRP): dimerization of the two protein components is required for efficient binding to SRP RNA. (PMID: 2153922) Strub K. … Walter P. (Mol. Cell. Biol. 1990) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SRP9 Gene

Sources for SRP9 Gene

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