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Aliases for SRP9 Gene

Aliases for SRP9 Gene

  • Signal Recognition Particle 9kDa 2 3 5
  • Signal Recognition Particle 9kD 2 3
  • ALURBP 3

External Ids for SRP9 Gene

Previous GeneCards Identifiers for SRP9 Gene

  • GC01P224447
  • GC01P221782
  • GC01P222372
  • GC01P222940
  • GC01P222272
  • GC01P224034
  • GC01P225965
  • GC01P196483

Summaries for SRP9 Gene

GeneCards Summary for SRP9 Gene

SRP9 (Signal Recognition Particle 9kDa) is a Protein Coding gene. Among its related pathways are Gene Expression and Transport to the Golgi and subsequent modification. GO annotations related to this gene include RNA binding and signal recognition particle binding.

UniProtKB/Swiss-Prot for SRP9 Gene

  • Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRP9 Gene

Genomics for SRP9 Gene

Regulatory Elements for SRP9 Gene

Promoters for SRP9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SRP9 on UCSC Golden Path with GeneCards custom track

Genomic Location for SRP9 Gene

Chromosome:
1
Start:
225,777,813 bp from pter
End:
225,790,466 bp from pter
Size:
12,654 bases
Orientation:
Plus strand

Genomic View for SRP9 Gene

Genes around SRP9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRP9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRP9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRP9 Gene

Proteins for SRP9 Gene

  • Protein details for SRP9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49458-SRP09_HUMAN
    Recommended name:
    Signal recognition particle 9 kDa protein
    Protein Accession:
    P49458
    Secondary Accessions:
    • A8K0N0
    • Q6NVX0
    • Q8WTW0

    Protein attributes for SRP9 Gene

    Size:
    86 amino acids
    Molecular mass:
    10112 Da
    Quaternary structure:
    • Signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.

    Three dimensional structures from OCA and Proteopedia for SRP9 Gene

    Alternative splice isoforms for SRP9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRP9 Gene

Proteomics data for SRP9 Gene at MOPED

Post-translational modifications for SRP9 Gene

  • Ubiquitination at Lys 16, Lys 64, and Lys 76
  • Modification sites at PhosphoSitePlus

Other Protein References for SRP9 Gene

No data available for DME Specific Peptides for SRP9 Gene

Domains & Families for SRP9 Gene

Protein Domains for SRP9 Gene

Suggested Antigen Peptide Sequences for SRP9 Gene

Graphical View of Domain Structure for InterPro Entry

P49458

UniProtKB/Swiss-Prot:

SRP09_HUMAN :
  • Belongs to the SRP9 family.
Family:
  • Belongs to the SRP9 family.
genes like me logo Genes that share domains with SRP9: view

No data available for Gene Families for SRP9 Gene

Function for SRP9 Gene

Molecular function for SRP9 Gene

UniProtKB/Swiss-Prot Function:
Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.

Gene Ontology (GO) - Molecular Function for SRP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008312 7S RNA binding IEA --
genes like me logo Genes that share ontologies with SRP9: view
genes like me logo Genes that share phenotypes with SRP9: view

Animal Models for SRP9 Gene

MGI Knock Outs for SRP9:
  • Srp9 tm1.1(KOMP)Vlcg

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SRP9 Gene

Localization for SRP9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRP9 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRP9 Gene COMPARTMENTS Subcellular localization image for SRP9 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
extracellular 5
nucleus 1

Gene Ontology (GO) - Cellular Components for SRP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005785 signal recognition particle receptor complex TAS 7730321
genes like me logo Genes that share ontologies with SRP9: view

Pathways & Interactions for SRP9 Gene

genes like me logo Genes that share pathways with SRP9: view

Pathways by source for SRP9 Gene

Gene Ontology (GO) - Biological Process for SRP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with SRP9: view

No data available for SIGNOR curated interactions for SRP9 Gene

Drugs & Compounds for SRP9 Gene

No Compound Related Data Available

Transcripts for SRP9 Gene

Unigene Clusters for SRP9 Gene

Signal recognition particle 9kDa:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRP9 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: -
SP2: - - -
SP3: -

Relevant External Links for SRP9 Gene

GeneLoc Exon Structure for
SRP9
ECgene alternative splicing isoforms for
SRP9

Expression for SRP9 Gene

mRNA expression in normal human tissues for SRP9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SRP9 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SRP9 Gene



SOURCE GeneReport for Unigene cluster for SRP9 Gene Hs.511425

genes like me logo Genes that share expression patterns with SRP9: view

Protein tissue co-expression partners for SRP9 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SRP9 Gene

Orthologs for SRP9 Gene

This gene was present in the common ancestor of animals.

Orthologs for SRP9 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia SRP9 35
  • 94.19 (n)
  • 91.86 (a)
SRP9 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srp9 35
  • 88.37 (n)
  • 93.02 (a)
Srp9 16
Srp9 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SRP9 35
  • 100 (n)
  • 100 (a)
SRP9 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Srp9 35
  • 86.82 (n)
  • 90.7 (a)
cow
(Bos Taurus)
Mammalia SRP9 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SRP9 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRP9 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves SRP9 35
  • 83.72 (n)
  • 82.56 (a)
SRP9 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRP9 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia srp9 35
  • 81.4 (n)
  • 81.4 (a)
Str.17011 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.5226 35
zebrafish
(Danio rerio)
Actinopterygii srp9 35
  • 71.32 (n)
  • 77.91 (a)
zgc56668 35
srp9 36
  • 78 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Srp9 36
  • 40 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ZK512.4 36
  • 51 (a)
OneToOne
Species with no ortholog for SRP9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRP9 Gene

ENSEMBL:
Gene Tree for SRP9 (if available)
TreeFam:
Gene Tree for SRP9 (if available)

Paralogs for SRP9 Gene

(1) SIMAP similar genes for SRP9 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SRP9: view

No data available for Paralogs for SRP9 Gene

Variants for SRP9 Gene

Sequence variations from dbSNP and Humsavar for SRP9 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs14113 -- 225,790,305(+) TAAAT(C/G)TAATG utr-variant-3-prime
rs1130900 -- 225,786,879(+) GCTCT(A/G)TTGCT intron-variant, reference, synonymous-codon
rs1130901 -- 225,786,912(+) ATCAT(A/G)GCTCA intron-variant, reference, missense
rs1050033 -- 225,790,266(+) AAGTA(C/T)GATAT utr-variant-3-prime
rs1461957 -- 225,778,130(-) AGGGT(A/C)CATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRP9 Gene

Variant ID Type Subtype PubMed ID
nsv832736 CNV Loss 17160897
nsv524126 CNV Gain 19592680

Variation tolerance for SRP9 Gene

Residual Variation Intolerance Score: 55.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.14; 3.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRP9 Gene

HapMap Linkage Disequilibrium report
SRP9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRP9 Gene

Disorders for SRP9 Gene

Relevant External Links for SRP9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRP9

No disorders were found for SRP9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRP9 Gene

Publications for SRP9 Gene

  1. Human signal recognition particle (SRP) Alu-associated protein also binds Alu interspersed repeat sequence RNAs. Characterization of human SRP9. (PMID: 7730321) Hsu K. … Maraia R.J. (J. Biol. Chem. 1995) 2 3 4 67
  2. Proteomic expression analysis of surgical human colorectal cancer tissues: up-regulation of PSB7, PRDX1, and SRP9 and hypoxic adaptation in cancer. (PMID: 18549262) Rho J.H. … Roehrl M.H. (J. Proteome Res. 2008) 3 23
  3. Structure and assembly of the Alu domain of the mammalian signal recognition particle. (PMID: 11089964) Weichenrieder O. … Cusack S. (Nature 2000) 3 23
  4. Assembly of the Alu domain of the signal recognition particle (SRP): dimerization of the two protein components is required for efficient binding to SRP RNA. (PMID: 2153922) Strub K. … Walter P. (Mol. Cell. Biol. 1990) 3 23
  5. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3

Products for SRP9 Gene

Sources for SRP9 Gene

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