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SRP68 Gene

protein-coding   GIFtS: 55
GCID: GC17M074035

Signal Recognition Particle 68kDa

(Previous name: signal recognition particle 68kD)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Signal Recognition Particle 68kDa1 2
Signal Recognition Particle 68 KDa Protein2 3
Signal Recognition Particle 68kD1
Signal Recognition Particle Subunit SRP682

External Ids:    HGNC: 113021   Entrez Gene: 67302   Ensembl: ENSG000001678817   OMIM: 6048585   UniProtKB: Q9UHB93   

Export aliases for SRP68 gene to outside databases

Previous GC identifers: GC17P073853 GC17M077061 GC17M074499 GC17M074632 GC17M071546 GC17M069460


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SRP68 Gene:
This gene encodes a subunit of the signal recognition particle (SRP). The SRP is a ribonucleoprotein complex that
transports secreted and membrane proteins to the endoplasmic reticulum for processing. The complex includes a 7S
RNA and six protein subunits. The encoded protein is the 68kDa component of the SRP, and forms a heterodimer with
the 72kDa subunit that is required for SRP function. Alternatively spliced transcript variants encoding multiple
isoforms have been observed for this gene, and three pseudogenes of this gene are located within the
Smith-Magenis syndrome region on chromosome 17. (provided by RefSeq, May 2012)

GeneCards Summary for SRP68 Gene:
SRP68 (signal recognition particle 68kDa) is a protein-coding gene. GO annotations related to this gene include endoplasmic reticulum signal peptide binding and 7S RNA binding.

UniProtKB/Swiss-Prot: SRP68_HUMAN, Q9UHB9
Function: Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough
endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This
ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly
participate in the elongation arrest function




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the SRP68 gene promoter:
         USF1   FAC1   RREB-1   USF-1   MyoD   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSRP68 promoter sequence
   Search Chromatin IP Primers for SRP68

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SRP68


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25.1

SRP68 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRP68 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M074035:  view genomic region     (about GC identifiers)

Start:
74,035,184 bp from pter      End:
74,068,734 bp from pter
Size:
33,551 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SRP68_HUMAN, Q9UHB9 (See protein sequence)
Recommended Name: Signal recognition particle subunit SRP68  
Size: 627 amino acids; 70730 Da
Subunit: Signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits:
SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9
Secondary accessions: B3KUU5 B3KWY7 G3V1U4 Q8NCJ4 Q8WUK2
Alternative splicing: 4 isoforms:  Q9UHB9-1   Q9UHB9-2   Q9UHB9-3   Q9UHB9-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SRP68: NX_Q9UHB9

Explore proteomics data for SRP68 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys142, Lys205, Lys220, Lys277, Lys504
  • Modification sites at PhosphoSitePlus

  • See SRP68 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001247431.1  NP_001247432.1  NP_055045.2  

    ENSEMBL proteins: 
     ENSP00000312066   ENSP00000446136   ENSP00000466791   ENSP00000467765   ENSP00000347233  
     ENSP00000473613  
    Reactome Protein details: Q9UHB9

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026258 SRP68

    Graphical View of Domain Structure for InterPro Entry Q9UHB9

    ProtoNet protein and cluster: Q9UHB9

    UniProtKB/Swiss-Prot: SRP68_HUMAN, Q9UHB9
    Domain: The RNA-binding domain is located near the N-terminus
    Similarity: Belongs to the SRP68 family


    Find genes that share domains with SRP68           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRP68_HUMAN, Q9UHB9
    Function: Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough
    endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This
    ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly
    participate in the elongation arrest function

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005047signal recognition particle binding IPI17254600
    GO:00083127S RNA binding IEA--
    GO:0030942endoplasmic reticulum signal peptide binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with SRP68           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SRP68:
     Increased gamma-H2AX phosphory  Metaphase cells 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SRP68

    miRNA
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    miRTarBase miRNAs that target SRP68:
    hsa-mir-92b-3p (MIRT040611), hsa-mir-221-3p (MIRT046920), hsa-mir-365a-3p (MIRT044023), hsa-mir-320b (MIRT036207), hsa-mir-16-5p (MIRT031372), hsa-mir-320a (MIRT044563)

    Block miRNA regulation of human, mouse, rat SRP68 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate SRP68:
    hsa-miR-607 hsa-miR-889 hsa-miR-3121-3p hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidSRP68 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SRP68_HUMAN, Q9UHB9: Cytoplasm. Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    endoplasmic reticulum4
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm ----
    GO:0005783endoplasmic reticulum TAS10618370
    GO:0005786signal recognition particle, endoplasmic reticulum targeting IDA18089836
    GO:0005829cytosol TAS--

    Find genes that share ontologies with SRP68           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SRP68 About    
    See pathways by source

    SuperPathContained pathways About
    1Influenza Viral RNA Transcription and Replication
    SRP-dependent cotranslational protein targeting to membrane0.83
    Translation0.82
    2Gene Expression
    Gene Expression0.40
    3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    4Protein export
    Protein export


    Find genes that share SuperPaths with SRP68           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for SRP68
        SRP-dependent cotranslational protein targeting to membrane


    1 Kegg Pathway  (Kegg details for SRP68):
        Protein export

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SRP68
    Interactions:

        GeneGlobe Interaction Network for SRP68

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SRP68 (Q9UHB92, 3 ENSP000003120664) via UniProtKB, MINT, STRING, and/or I2D (see all 864)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EEF1A1P681042, 3MINT-7945693 MINT-7947479 I2D: score=4 
    TUBGCP2Q9BSJ22, 3MINT-7945693 MINT-7947479 I2D: score=2 
    PRPF3O433952, 3MINT-7947479 I2D: score=4 
    PRKAG1P546192, 3MINT-7945693 I2D: score=1 
    SRP72O760942, 3, ENSP000003421814MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000342181
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation TAS--
    GO:0006614SRP-dependent cotranslational protein targeting to membrane TAS--
    GO:0010467gene expression TAS--
    GO:0042493response to drug IDA18089836
    GO:0044267cellular protein metabolic process TAS--

    Find genes that share ontologies with SRP68           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for SRP68



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SRP68 gene (3 alternative transcripts): 
    NM_001260502.1  NM_001260503.1  NM_014230.3  

    Unigene Cluster for SRP68:

    Signal recognition particle 68kDa
    Hs.514495  [show with all ESTs]
    Unigene Representative Sequence: NM_014230
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000307877(uc010wsu.1 uc002jqk.1 uc002jql.1) ENST00000588643
    ENST00000542536(uc002jqj.1) ENST00000539137 ENST00000592704 ENST00000586859
    ENST00000588736 ENST00000590833 ENST00000587864 ENST00000585539 ENST00000591272
    ENST00000355113 ENST00000602720
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate SRP68:
    hsa-miR-607 hsa-miR-889 hsa-miR-3121-3p hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidSRP68 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SRP68
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    GenScript: all cDNA clones in your preferred vector: SRP68 (NM_014230)
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    OriGene qSTAR qPCR primer pairs in human, mouse for SRP68
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SRP68
      QuantiTect SYBR Green Assays in human, mouse, rat SRP68
      QuantiFast Probe-based Assays in human, mouse, rat SRP68

    Additional mRNA sequence: 

    AF195951.1 AK002002.1 AK027320.1 AK074698.1 AK092935.1 AK097962.1 AK098159.1 AK126258.1 
    AK301100.1 AL512708.1 BC000760.2 BC013308.2 BC020238.1 DQ786315.1 NR_048541.1 

    18 DOTS entries:

    DT.320000  DT.100819055  DT.92050847  DT.100819063  DT.100819068  DT.91788828  DT.100038515  DT.121642914 
    DT.95212681  DT.95337643  DT.95337661  DT.120960359  DT.120960389  DT.91757181  DT.91798255  DT.92059678 
    DT.95337662  DT.97800583 

    Selected AceView cDNA sequences (see all 391):

    BI222673 AA024576 BU528289 BU951873 BE898539 BU931113 AA088852 BU168538 
    CB143293 BU189310 BU952059 BU838809 AA741295 BM563633 CB151633 BU622605 
    F37312 CD243109 BQ645172 BE043299 BU156491 AA885681 AK097962 AW248056 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SRP68 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b
    SP1:                                                              -                                                     -     -                                 
    SP2:                    -                                         -                                                     -     -                                 
    SP3:                                            -     -           -                                                     -     -                                 
    SP4:                                                                                                                    -     -                                 
    SP5:        -                                                                                                                                                   


    ECgene alternative splicing isoforms for SRP68

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SRP68 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATTTGAAAT
    SRP68 Expression
    About this image


    SRP68 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Thyroid (Endocrine System)
    SRP68 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SRP68 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.514495
        Custom PCR Arrays for SRP68
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRP68

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SRP68 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srp681 , 5 signal recognition particle 681, 5 87.52(n)1
    94.88(a)1
      11 (81.06 cM)5
    2173371  NM_146032.31  NP_666144.31 
     1162451665 
    chicken
    (Gallus gallus)
    Aves SRP681 signal recognition particle 68kDa 79.29(n)
    89.81(a)
      417363  NM_001006204.1  NP_001006204.1 
    lizard
    (Anolis carolinensis)
    Reptilia SRP686
    signal recognition particle 68kDa
    70(a)
    1 ↔ 1
    2(113189612-113216929)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.19152 Xenopus laevis transcribed sequence with moderate similarity more 78.52(n)    BQ387256.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.296922 Transcribed sequence with moderate similarity to protein more 78.35(n)    57066918 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG50643
    Srp681
    SRP-dependent, co-translational
    membrane targeting more3
    Signal recognition particle protein 681
    42(a)3
    51.92(n)1
    44.42(a)1
      390281  NM_140016.31  NP_648273.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F55C5.83
    CELE_F55C5.81
    signal recognition particle 68 KD
    protein3
    CELE_F55C5.81
    31(a)3
    46.16(n)1
    36.19(a)1
      V(12291912-12294250)3
    1796861  NM_073682.41  NP_506083.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G619701 AT5G61970 47.26(n)
    36.04(a)
      836318  NM_125590.2  NP_568947.1 
    rice
    (Oryza sativa)
    Liliopsida Os08g03230001 Os08g0323000 45.79(n)
    29.12(a)
      4345269  NM_001068075.1  NP_001061540.1 


    ENSEMBL Gene Tree for SRP68 (if available)
    TreeFam Gene Tree for SRP68 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SRP68 gene

    Find genes that share paralogs with SRP68           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for SRP68
    PGOHUM00000259153 PGOHUM00000236960 PGOHUM00000237259


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SRP68 (see all 734)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs680776651,2
    C--69492692(-) AAATT-/TGTGTGT 3 -- int12Minor allele frequency- TG:0.25NA 4
    rs775709721,2
    F--74034366(+) TCATCT/GGGTCT 4 -- ds50011Minor allele frequency- G:0.01WA 118
    rs1830058041,2
    --74034376(+) TTGTAA/GCCCCC 4 -- ds50010--------
    rs1997307691,2
    --74034446(+) CTCCC-/TATGACT 4 -- ds50010--------
    rs1406956021,2
    --74034476(+) ACTTCA/GTCTCC 4 -- ds50010--------
    rs1445095241,2
    --74034565(+) TCAGGA/GAGACC 4 -- ds50010--------
    rs766747891,2
    C,F--74034572(+) GACCAA/GTGTGA 4 -- ds50011Minor allele frequency- G:0.06WA 118
    rs620900831,2
    C,F--74034631(+) CTCTAT/CTGCAA 4 -- ds50012Minor allele frequency- C:0.02NA 122
    rs1859368321,2
    --74034672(+) GCAGCA/GGGCAA 4 -- ds50010--------
    rs1903529291,2
    --74034686(+) CCCTCA/GGGGGG 4 -- ds50010--------

    HapMap Linkage Disequilibrium report for SRP68 (74035184 - 74068734 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for SRP68:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509674CNV Insertion20534489
    nsv2142CNV Insertion18451855
    esv273820CNV Insertion20981092
    esv270157CNV Insertion20981092
    esv2588678CNV Insertion19546169
    nsv833546CNV Loss17160897
    nsv908826CNV Loss21882294
    nsv908825CNV Loss21882294
    nsv908824CNV Loss21882294
    dgv3270n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SRP68
    DNA2.0 Custom Variant and Variant Library Synthesis for SRP68

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604858    OMIM disorders: --


    Find genes that share disorders with SRP68           About GenesLikeMe


    Export disorders for SRP68 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SRP68 gene, integrated from 10 sources (see all 51):
    (articles sorted by number of sources associating them with SRP68)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Signal recognition particle components in the nucleolus. (PubMed id 10618370)1, 2, 3 Politz J.C.... Pederson T. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Protein SRP68 of human signal recognition particle: identification of the RNA and SRP72 binding domains. (PubMed id 16672232)1, 9 Iakhiaeva E....Zwieb C. (Protein Sci. 2006)
    5. Anti-cooperative assembly of the SRP19 and SRP68/72 components of the signal recognition particle. (PubMed id 18564060)1, 9 Maity T.S....Weeks K.M. (Biochem. J. 2008)
    6. The Signal Recognition Particle Database (SRPDB). (PubMed id 9399828)1, 9 Larsen N....Zwieb C. (Nucleic Acids Res. 1998)
    7. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1 Cloutier P.... Coulombe B. (PLoS Genet. 2013)
    8. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    9. Implication of the SMN complex in the biogenesis and steady state level of the signal recognition particle. (PubMed id 23221635)1 Piazzon N....Massenet S. (Nucleic Acids Res. 2013)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6730 HGNC: 11302 AceView: SRP68 Ensembl:ENSG00000167881 euGenes: HUgn6730
    ECgene: SRP68 Kegg: 6730 H-InvDB: SRP68

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SRP68 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Signal-recognition_particle

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SRP68 gene:
    Search GeneIP for patents involving SRP68

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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