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Aliases for SRP68 Gene

Aliases for SRP68 Gene

  • Signal Recognition Particle 68 2 3
  • Signal Recognition Particle 68kDa 2 5
  • Signal Recognition Particle 68 KDa Protein 4
  • Signal Recognition Particle 68kD 2

External Ids for SRP68 Gene

Previous GeneCards Identifiers for SRP68 Gene

  • GC17P073853
  • GC17M077061
  • GC17M074499
  • GC17M074632
  • GC17M071546
  • GC17M074035
  • GC17M069460

Summaries for SRP68 Gene

Entrez Gene Summary for SRP68 Gene

  • This gene encodes a subunit of the signal recognition particle (SRP). The SRP is a ribonucleoprotein complex that transports secreted and membrane proteins to the endoplasmic reticulum for processing. The complex includes a 7S RNA and six protein subunits. The encoded protein is the 68kDa component of the SRP, and forms a heterodimer with the 72kDa subunit that is required for SRP function. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and three pseudogenes of this gene are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, May 2012]

GeneCards Summary for SRP68 Gene

SRP68 (Signal Recognition Particle 68) is a Protein Coding gene. Among its related pathways are Gene Expression and Transport to the Golgi and subsequent modification. GO annotations related to this gene include poly(A) RNA binding and signal recognition particle binding.

UniProtKB/Swiss-Prot for SRP68 Gene

  • Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRP68 Gene

Genomics for SRP68 Gene

Regulatory Elements for SRP68 Gene

Promoters for SRP68 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SRP68 on UCSC Golden Path with GeneCards custom track

Genomic Location for SRP68 Gene

Chromosome:
17
Start:
76,038,775 bp from pter
End:
76,072,653 bp from pter
Size:
33,879 bases
Orientation:
Minus strand

Genomic View for SRP68 Gene

Genes around SRP68 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRP68 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRP68 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRP68 Gene

Proteins for SRP68 Gene

  • Protein details for SRP68 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHB9-SRP68_HUMAN
    Recommended name:
    Signal recognition particle subunit SRP68
    Protein Accession:
    Q9UHB9
    Secondary Accessions:
    • B3KUU5
    • B3KWY7
    • G3V1U4
    • Q8NCJ4
    • Q8WUK2

    Protein attributes for SRP68 Gene

    Size:
    627 amino acids
    Molecular mass:
    70730 Da
    Quaternary structure:
    • Signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.

    Three dimensional structures from OCA and Proteopedia for SRP68 Gene

    Alternative splice isoforms for SRP68 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRP68 Gene

Proteomics data for SRP68 Gene at MOPED

Post-translational modifications for SRP68 Gene

  • Ubiquitination at Lys 142, Lys 205, Lys 220, Lys 277, and Lys 504
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SRP68 Gene

Domains & Families for SRP68 Gene

Protein Domains for SRP68 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9UHB9

UniProtKB/Swiss-Prot:

SRP68_HUMAN :
  • The RNA-binding domain is located near the N-terminus.
  • Belongs to the SRP68 family.
Domain:
  • The RNA-binding domain is located near the N-terminus.
Family:
  • Belongs to the SRP68 family.
genes like me logo Genes that share domains with SRP68: view

No data available for Gene Families for SRP68 Gene

Function for SRP68 Gene

Molecular function for SRP68 Gene

UniProtKB/Swiss-Prot Function:
Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function.

Gene Ontology (GO) - Molecular Function for SRP68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008312 7S RNA binding IEA --
genes like me logo Genes that share ontologies with SRP68: view
genes like me logo Genes that share phenotypes with SRP68: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SRP68

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SRP68 Gene

Localization for SRP68 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRP68 Gene

Cytoplasm. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRP68 Gene COMPARTMENTS Subcellular localization image for SRP68 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
nucleus 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SRP68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005925 focal adhesion IDA --
genes like me logo Genes that share ontologies with SRP68: view

Pathways & Interactions for SRP68 Gene

genes like me logo Genes that share pathways with SRP68: view

Pathways by source for SRP68 Gene

Gene Ontology (GO) - Biological Process for SRP68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with SRP68: view

No data available for SIGNOR curated interactions for SRP68 Gene

Drugs & Compounds for SRP68 Gene

No Compound Related Data Available

Transcripts for SRP68 Gene

Unigene Clusters for SRP68 Gene

Signal recognition particle 68kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SRP68 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP4: - -
SP5: -
SP6: - - - -
SP7:
SP8:

Relevant External Links for SRP68 Gene

GeneLoc Exon Structure for
SRP68
ECgene alternative splicing isoforms for
SRP68

Expression for SRP68 Gene

mRNA expression in normal human tissues for SRP68 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SRP68 Gene

This gene is overexpressed in Brain (19.7) and Lymph node (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SRP68 Gene



SOURCE GeneReport for Unigene cluster for SRP68 Gene Hs.514495

genes like me logo Genes that share expression patterns with SRP68: view

Protein tissue co-expression partners for SRP68 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SRP68 Gene

Orthologs for SRP68 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SRP68 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRP68 35
  • 99.03 (n)
  • 98.97 (a)
SRP68 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SRP68 35
  • 89.03 (n)
  • 95.99 (a)
SRP68 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRP68 35
  • 91.77 (n)
  • 97.08 (a)
SRP68 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srp68 16
Srp68 35
  • 87.52 (n)
  • 94.88 (a)
Srp68 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SRP68 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRP68 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Srp68 35
  • 87.68 (n)
  • 94.24 (a)
chicken
(Gallus gallus)
Aves SRP68 36
  • 89 (a)
OneToOne
SRP68 35
  • 79.29 (n)
  • 89.81 (a)
lizard
(Anolis carolinensis)
Reptilia SRP68 36
  • 70 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1915 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6140 35
srp68 35
  • 75.19 (n)
  • 83.13 (a)
zebrafish
(Danio rerio)
Actinopterygii srp68 36
  • 71 (a)
OneToOne
srp68 35
  • 71.56 (n)
  • 75.82 (a)
Dr.29692 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002183 35
  • 50.79 (n)
  • 45.55 (a)
fruit fly
(Drosophila melanogaster)
Insecta Srp68 36
  • 42 (a)
OneToOne
Srp68 35
  • 51.92 (n)
  • 44.42 (a)
CG5064 37
  • 42 (a)
worm
(Caenorhabditis elegans)
Secernentea srpa-68 36
  • 30 (a)
OneToOne
F55C5.8 37
  • 31 (a)
CELE_F55C5.8 35
  • 46.16 (n)
  • 36.19 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SRP68 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G61970 35
  • 47.26 (n)
  • 36.04 (a)
rice
(Oryza sativa)
Liliopsida Os08g0323000 35
  • 45.79 (n)
  • 29.12 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1809 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToOne
Species with no ortholog for SRP68:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRP68 Gene

ENSEMBL:
Gene Tree for SRP68 (if available)
TreeFam:
Gene Tree for SRP68 (if available)

Paralogs for SRP68 Gene

Pseudogenes.org Pseudogenes for SRP68 Gene

genes like me logo Genes that share paralogs with SRP68: view

No data available for Paralogs for SRP68 Gene

Variants for SRP68 Gene

Sequence variations from dbSNP and Humsavar for SRP68 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs7409 -- 76,039,462(-) GGGAA(A/G)GGGGC nc-transcript-variant, utr-variant-3-prime
rs1058617 -- 76,046,128(-) CTGCA(C/G)AGGGC nc-transcript-variant, reference, missense
rs2598445 -- 76,041,127(+) ACAAA(A/G)CAAAA intron-variant
rs2260516 -- 76,040,492(+) CAGGG(A/T)TTCAG intron-variant
rs2665979 -- 76,046,590(+) cagcc(C/T)gagta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRP68 Gene

Variant ID Type Subtype PubMed ID
nsv908824 CNV Loss 21882294
nsv908825 CNV Loss 21882294
nsv908826 CNV Loss 21882294
nsv833546 CNV Loss 17160897
dgv3270n71 CNV Loss 21882294
esv2588678 CNV Insertion 19546169
esv270157 CNV Insertion 20981092
esv273820 CNV Insertion 20981092
nsv509674 CNV Insertion 20534489
nsv2142 CNV Insertion 18451855

Variation tolerance for SRP68 Gene

Residual Variation Intolerance Score: 38.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.60; 45.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRP68 Gene

HapMap Linkage Disequilibrium report
SRP68

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRP68 Gene

Disorders for SRP68 Gene

Relevant External Links for SRP68

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRP68

No disorders were found for SRP68 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRP68 Gene

Publications for SRP68 Gene

  1. Signal recognition particle components in the nucleolus. (PMID: 10618370) Politz J.C. … Pederson T. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 3 4 67
  2. Anti-cooperative assembly of the SRP19 and SRP68/72 components of the signal recognition particle. (PMID: 18564060) Maity T.S. … Weeks K.M. (Biochem. J. 2008) 3 23
  3. Protein SRP68 of human signal recognition particle: identification of the RNA and SRP72 binding domains. (PMID: 16672232) Iakhiaeva E. … Zwieb C. (Protein Sci. 2006) 3 23
  4. The Signal Recognition Particle Database (SRPDB). (PMID: 9399828) Larsen N. … Zwieb C. (Nucleic Acids Res. 1998) 3 23
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for SRP68 Gene

Sources for SRP68 Gene

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