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Aliases for SRP54 Gene

Aliases for SRP54 Gene

  • Signal Recognition Particle 54kDa 2 3
  • Signal Recognition Particle 54kD 2

External Ids for SRP54 Gene

Summaries for SRP54 Gene

GeneCards Summary for SRP54 Gene

SRP54 (Signal Recognition Particle 54kDa) is a Protein Coding gene. Diseases associated with SRP54 include polyclonal hypergammaglobulinemia. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Gene Expression. GO annotations related to this gene include GTP binding and drug binding.

UniProtKB/Swiss-Prot for SRP54 Gene

  • Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein)

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRP54 Gene

Genomics for SRP54 Gene

Genomic Location for SRP54 Gene

34,981,957 bp from pter
35,029,567 bp from pter
47,611 bases
Plus strand

Genomic View for SRP54 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SRP54 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRP54 Gene

Regulatory Elements for SRP54 Gene

Proteins for SRP54 Gene

  • Protein details for SRP54 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Signal recognition particle 54 kDa protein
    Protein Accession:
    Secondary Accessions:
    • B2R759
    • B4DUW6
    • P13624

    Protein attributes for SRP54 Gene

    504 amino acids
    Molecular mass:
    55705 Da
    Quaternary structure:
    • Signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. Interacts with RNPS1.

    Three dimensional structures from OCA and Proteopedia for SRP54 Gene

    Alternative splice isoforms for SRP54 Gene


neXtProt entry for SRP54 Gene

Proteomics data for SRP54 Gene at MOPED

Post-translational modifications for SRP54 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys50, Lys311, Lys321, Lys426, Lys448, Lys457, and Lys464

Other Protein References for SRP54 Gene

No data available for DME Specific Peptides for SRP54 Gene

Domains for SRP54 Gene

Suggested Antigen Peptide Sequences for SRP54 Gene

Graphical View of Domain Structure for InterPro Entry



  • Has a two domain structure: the G-domain binds GTP; the M-domain binds the 7S RNA in presence of SRP19 and also binds the signal sequence:
    • P61011
  • Belongs to the GTP-binding SRP family. SRP54 subfamily.:
    • P61011
genes like me logo Genes that share domains with SRP54: view

No data available for Gene Families for SRP54 Gene

Function for SRP54 Gene

Molecular function for SRP54 Gene

UniProtKB/Swiss-Prot Function: Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein)

Gene Ontology (GO) - Molecular Function for SRP54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 contributes_to GTPase activity IDA 8247130
GO:0005525 GTP binding IDA 8622769
GO:0008144 drug binding IDA 18089836
GO:0008312 7S RNA binding IDA 18089836
GO:0019003 GDP binding IDA 8622769
genes like me logo Genes that share ontologies with SRP54: view

Phenotypes for SRP54 Gene

GenomeRNAi human phenotypes for SRP54:
genes like me logo Genes that share phenotypes with SRP54: view

miRNA for SRP54 Gene

miRTarBase miRNAs that target SRP54

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SRP54 Gene

Localization for SRP54 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRP54 Gene

Nucleus speckle. Cytoplasm.

Subcellular locations from

Jensen Localization Image for SRP54 Gene COMPARTMENTS Subcellular localization image for SRP54 gene
Compartment Confidence
nucleus 5
cytosol 4
chloroplast 2
endoplasmic reticulum 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SRP54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 18089836
GO:0005730 NOT nucleolus IDA 10618370
GO:0005737 cytoplasm IDA --
GO:0005786 signal recognition particle, endoplasmic reticulum targeting IDA 18089836
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SRP54: view

Pathways for SRP54 Gene

genes like me logo Genes that share pathways with SRP54: view

Pathways by source for SRP54 Gene

1 KEGG pathway for SRP54 Gene

Gene Ontology (GO) - Biological Process for SRP54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006412 translation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation ISS --
GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition ISS --
genes like me logo Genes that share ontologies with SRP54: view

Compounds for SRP54 Gene

(1) HMDB Compounds for SRP54 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP

(3) Novoseek inferred chemical compound relationships for SRP54 Gene

Compound -log(P) Hits PubMed IDs
preprolactin 86.2 1
gdp 45.2 1
gtp 40.4 6
genes like me logo Genes that share compounds with SRP54: view

Transcripts for SRP54 Gene

Unigene Clusters for SRP54 Gene

Signal recognition particle 54kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SRP54 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^
SP1: - - -
SP3: -
SP4: - - -
SP5: - -
SP6: - - -

ExUns: 19 ^ 20

Relevant External Links for SRP54 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SRP54 Gene

mRNA expression in normal human tissues for SRP54 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SRP54 Gene

SOURCE GeneReport for Unigene cluster for SRP54 Gene Hs.167535

genes like me logo Genes that share expressions with SRP54: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SRP54 Gene

Orthologs for SRP54 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SRP54 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SRP54 35
  • 100 (n)
  • 100 (a)
SRP54 36
  • 100 (a)
(Bos Taurus)
Mammalia SRP54 35
  • 95.24 (n)
  • 100 (a)
SRP54 36
  • 100 (a)
(Canis familiaris)
Mammalia SRP54 35
  • 95.7 (n)
  • 100 (a)
SRP54 36
  • 100 (a)
(Mus musculus)
Mammalia Srp54a 16
Srp54a 36
  • 100 (a)
Srp54b 35
  • 92.2 (n)
  • 99.8 (a)
Srp54b 36
  • 100 (a)
Srp54c 36
  • 99 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 100 (a)
-- 36
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia SRP54 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Srp54a 35
  • 91.67 (n)
  • 99.6 (a)
(Gallus gallus)
Aves SRP54 35
  • 86.97 (n)
  • 98.81 (a)
SRP54 36
  • 97 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 99 (a)
-- 36
  • 85 (a)
-- 36
  • 96 (a)
African clawed frog
(Xenopus laevis)
Amphibia srp54-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75926 35
srp54 35
  • 82.41 (n)
  • 96.83 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10862 35
(Danio rerio)
Actinopterygii srp54 35
  • 79.83 (n)
  • 96.03 (a)
srp54 36
  • 96 (a)
zgc55842 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004610 35
  • 68.86 (n)
  • 79.84 (a)
fruit fly
(Drosophila melanogaster)
Insecta Srp54k 35
  • 66.93 (n)
  • 77.11 (a)
Srp54k 36
  • 76 (a)
Srp54k 37
  • 77 (a)
(Caenorhabditis elegans)
Secernentea F21D5.7 35
  • 68.15 (n)
  • 72.41 (a)
F21D5.7 36
  • 72 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR041W 35
  • 52.92 (n)
  • 52.22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SRP54 35
  • 57.54 (n)
  • 51.12 (a)
SRP54 36
  • 47 (a)
SRP54 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D09020g 35
  • 56.88 (n)
  • 52.43 (a)
(Glycine max)
eudicotyledons Gma.1605 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G48900 35
  • 61.77 (n)
  • 58.57 (a)
(Hordeum vulgare)
Liliopsida Hv.49 35
(Oryza sativa)
Liliopsida Os01g0772800 35
  • 58.33 (n)
  • 59.15 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09696 35
  • 57.26 (n)
  • 57.47 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes srp54 35
  • 59.27 (n)
  • 56.66 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15538 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 71 (a)
Species with no ortholog for SRP54:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRP54 Gene

Gene Tree for SRP54 (if available)
Gene Tree for SRP54 (if available)

Paralogs for SRP54 Gene

No data available for Paralogs for SRP54 Gene

Variants for SRP54 Gene

Sequence variations from dbSNP and Humsavar for SRP54 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs799455 -- 35,020,163(-) ctgtc(A/G)cccag intron-variant
rs799456 -- 35,019,802(-) taaac(A/G)taact intron-variant
rs799457 -- 35,017,135(-) gctca(C/T)gcctg intron-variant
rs799458 -- 35,017,124(-) taatc(C/T)cagca intron-variant
rs799459 -- 35,016,542(-) aagtg(C/T)aagta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRP54 Gene

Variant ID Type Subtype PubMed ID
nsv483012 CNV Complex 15286789
nsv901602 CNV Loss 21882294
dgv1870n71 CNV Loss 21882294
nsv901606 CNV Loss 21882294
nsv901607 CNV Loss 21882294
dgv1871n71 CNV Loss 21882294
nsv901610 CNV Loss 21882294
nsv901611 CNV Gain 21882294
nsv901612 CNV Gain+Loss 21882294
esv993561 OTHER Inversion 20482838
esv1401960 CNV Insertion 17803354
nsv1239 CNV Loss 18451855
esv1009559 CNV Insertion 20482838
nsv901614 CNV Loss 21882294
nsv901615 CNV Loss 21882294

Relevant External Links for SRP54 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRP54 Gene

Disorders for SRP54 Gene

(1) University of Copenhagen DISEASES for SRP54 Gene

Relevant External Links for SRP54

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SRP54: view

No data available for UniProtKB/Swiss-Prot for SRP54 Gene

Publications for SRP54 Gene

  1. Crystal structure of the conserved subdomain of human protein SRP54M at 2.1 A resolution: evidence for the mechanism of signal peptide binding. (PMID: 10497032) Clemons W.M. Jr. … Ramakrishnan V. (J. Mol. Biol. 1999) 3 4 23
  2. Induced structural changes of 7SL RNA during the assembly of human signal recognition particle. (PMID: 12244299) Kuglstatter A. … Nagai K. (Nat. Struct. Biol. 2002) 3 4 23
  3. Protein SRP54 of human signal recognition particle: cloning, expression, and comparative analysis of functional sites. (PMID: 9511762) Gowda K. … Zwieb C. (Gene 1998) 3 4 23
  4. Sequence of the highly conserved gene encoding the human 54kDa subunit of signal recognition particle. (PMID: 8722571) Patel S. … Austen B. (DNA Seq. 1996) 2 3 4
  5. Assembly of the human signal recognition particle (SRP): overlap of regions required for binding of protein SRP54 and assembly control. (PMID: 11680843) Yin J. … Zwieb C. (RNA 2001) 3 23

Products for SRP54 Gene

Sources for SRP54 Gene

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