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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SRP54 Gene

protein-coding   GIFtS: 62
GCID: GC14P035452

Signal Recognition Particle 54kDa

(Previous name: signal recognition particle 54kD)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Signal Recognition Particle 54kDa1 2
Signal Recognition Particle 54kD1
Signal Recognition Particle 54 KDa Protein2

External Ids:    HGNC: 113011   Entrez Gene: 67292   Ensembl: ENSG000001008837   OMIM: 6048575   UniProtKB: P610113   

Export aliases for SRP54 gene to outside databases

Previous GC identifers: GC14P032830 GC14P029239 GC14P033442 GC14P034521 GC14P015564


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SRP54 Gene: 
SRP54 (signal recognition particle 54kDa) is a protein-coding gene. Diseases associated with SRP54 include polyclonal hypergammaglobulinemia, and pneumonia, and among its related super-pathways are Viral mRNA Translation and Generic Transcription Pathway. GO annotations related to this gene include drug binding and GTP binding.

UniProtKB/Swiss-Prot: SRP54_HUMAN, P61011
Function: Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers
them to TRAM (translocating chain-associating membrane protein)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SRP54 gene promoter:
         HOXA9   HOXA9B   LHX3b/Lhx3b   p53   Meis-1b   RORalpha1   LHX3a/Lhx3a   c-Jun   Msx-1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSRP54 promoter sequence
   Search SABiosciences Chromatin IP Primers for SRP54

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRP54


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q13.2   Ensembl cytogenetic band:  14q13.2   HGNC cytogenetic band: 14q13.2

SRP54 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRP54 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P035452:  view genomic region     (about GC identifiers)

Start:
35,451,163 bp from pter      End:
35,498,773 bp from pter
Size:
47,611 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SRP54_HUMAN, P61011 (See protein sequence)
Recommended Name: Signal recognition particle 54 kDa protein  
Size: 504 amino acids; 55705 Da
Subunit: Signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits:
SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. Interacts with RNPS1
Subcellular location: Nucleus speckle. Cytoplasm
2 PDB 3D structures from and Proteopedia for SRP54:
1MFQ (3D)        1QB2 (3D)    
Secondary accessions: B2R759 B4DUW6 P13624
Alternative splicing: 2 isoforms:  P61011-1   P61011-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SRP54: NX_P61011

Explore proteomics data for SRP54 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P61011

  • SRP54 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SRP54 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001139754.1  NP_003127.1  

    ENSEMBL proteins: 
     ENSP00000451818   ENSP00000451037   ENSP00000451647   ENSP00000451775   ENSP00000451313  
     ENSP00000216774   ENSP00000440629  
    Reactome Protein details: P61011
    Human Recombinant Protein Products for SRP54: 
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    Novus Biologicals SRP54 Proteins
    Novus Biologicals SRP54 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for SRP54
    Cloud-Clone Corp. Proteins for SRP54 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA18089836
    GO:0005730NOT nucleolus IDA10618370
    GO:0005737cytoplasm IDA--
    GO:0005786signal recognition particle, endoplasmic reticulum targeting IDA18089836
    GO:0005829cytosol TAS--

    SRP54 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/7 InterPro protein domains (see all 7):
     IPR013822 Signal_recog_particl_SRP54_hlx
     IPR004125 Signal_recog_particle_SRP54_M
     IPR027417 P-loop_NTPase
     IPR006325 SRP54_euk
     IPR003593 AAA+_ATPase

    Graphical View of Domain Structure for InterPro Entry P61011

    ProtoNet protein and cluster: P61011

    1 Blocks protein domain: IPB000897 GTP-binding signal recognition particle (SRP54) G-domain

    UniProtKB/Swiss-Prot: SRP54_HUMAN, P61011
    Domain: Has a two domain structure: the G-domain binds GTP; the M-domain binds the 7S RNA in presence of SRP19 and
    also binds the signal sequence
    Similarity: Belongs to the GTP-binding SRP family. SRP54 subfamily


    SRP54 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRP54_HUMAN, P61011
    Function: Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers
    them to TRAM (translocating chain-associating membrane protein)

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0003924contributes to GTPase activity IDA8247130
    GO:0005525GTP binding IDA8622769
    GO:0008144drug binding IDA18089836
    GO:00083127S RNA binding IDA18089836
         
    SRP54 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SRP54:
     Decreased influenza A virus in  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SRP54 
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    SwitchGear 3'UTR luciferase reporter plasmidSRP54 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SRP54 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Viral mRNA Translation
    Translation0.78
    SRP-dependent cotranslational protein targeting to membrane0.77
    2Generic Transcription Pathway
    Gene Expression0.47
    3mRNA Splicing - Major Pathway
    mRNA processing0.46
    4Asparagine N-linked glycosylation
    Metabolism of proteins0.35
    5Protein export
    Protein export

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SRP54
        mRNA processing

    4        Reactome Pathways for SRP54
        Translation
    SRP-dependent cotranslational protein targeting to membrane
    Metabolism of proteins
    Gene Expression


    1         Kegg Pathway  (Kegg details for SRP54):
        Protein export


    SRP54 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SRP54

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/901 Interacting proteins for SRP54 (P610112, 3 ENSP000002167744) via UniProtKB, MINT, STRING, and/or I2D (see all 901)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSMC2P359982, 3MINT-7945693 MINT-7947479 I2D: score=2 
    SRP19P091322, 3, ENSP000002829994MINT-7945693 I2D: score=2 STRING: ENSP00000282999
    CCT2P783712, 3MINT-7945693 MINT-7947479 I2D: score=1 
    CCT3P493682, 3MINT-7945693 MINT-7947479 I2D: score=1 
    CCT5P486432, 3MINT-7945693 MINT-7947479 I2D: score=1 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process IDA8247130
    GO:0006412translation TAS--
    GO:0006614SRP-dependent cotranslational protein targeting to membrane TAS--
    GO:0006616SRP-dependent cotranslational protein targeting to membrane, translocation ISS--
    GO:0006617SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition ISS--

    SRP54 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SRP54 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SRP54

    1 HMDB Compound for SRP54    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    3 Novoseek inferred chemical compound relationships for SRP54 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    preprolactin 86.2 2 1314169 (1)
    gdp 45.2 1 11566135 (1)
    gtp 40.4 7 7803856 (4), 9182758 (2)

    Search CenterWatch for drugs/clinical trials and news about SRP54

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SRP54 gene (2 alternative transcripts): 
    NM_001146282.1  NM_003136.3  

    Unigene Cluster for SRP54:

    Signal recognition particle 54kDa
    Hs.167535  [show with all ESTs]
    Unigene Representative Sequence: NM_003136
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000556994(uc001wso.3 uc010tpp.2 uc010tpq.2) ENST00000554803
    ENST00000555746 ENST00000553544 ENST00000555317 ENST00000555557 ENST00000556380
    ENST00000555535 ENST00000553923 ENST00000556445 ENST00000556992 ENST00000216774
    ENST00000546080
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Inhib. RNA
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    Additional mRNA sequence: 

    AK293319.1 AK300824.1 AK312853.1 BC000652.2 BC003389.1 U51920.1 

    17 DOTS entries:

    DT.100760554  DT.114758  DT.120752967  DT.91983420  DT.100707312  DT.40239500  DT.100837892  DT.114756 
    DT.100770224  DT.100837891  DT.91801229  DT.99927758  DT.100808302  DT.100837895  DT.95089736  DT.95238783 
    DT.99982255 

    24/216 AceView cDNA sequences (see all 216):

    CB139197 BC003389 CN478830 AI022848 BX460685 CA432262 BM833274 CR622716 
    AI921094 BM684754 BF514603 NM_003136 AA079666 BI966684 CD557634 BM971271 
    AA827709 BQ064739 CB153419 BM461572 AI351325 CA417580 BM467807 BG529997 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SRP54 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^
    SP1:                                      -                                   -                                                                       -         
    SP2:                                                                                                                                                            
    SP3:                                                                          -                                                                                 
    SP4:        -     -                       -                                                                                                                     
    SP5:                          -           -                                                                                                                     

    ExUns: 19 ^ 20
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for SRP54

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SRP54 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGTAAAATT
    SRP54 Expression
    About this image


    See SRP54 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SRP54

    SOURCE GeneReport for Unigene cluster: Hs.167535
        SABiosciences Custom PCR Arrays for SRP54
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SRP54 gene from 10/27 species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srp54a5
    Srp54b1
    signal recognition particle 54A5
    signal recognition particle 54B1
    92.2(n)1
    99.8(a)1
      12 (23.86 cM)5
    6651551  NM_001100109.11  NP_001093579.11 
     550892025 
    chicken
    (Gallus gallus)
    Aves SRP541 signal recognition particle 54kDa 86.97(n)
    98.81(a)
      423322  XM_421238.3  XP_421238.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    99(a)
    96(a)
    (see all 3)
    many → 1
    many → 1
    (see all 3)
    2(54574067-54588250)
    AAWZ02039108(1603-9454)
    African clawed frog
    (Xenopus laevis)
    Amphibia srp54-prov2 signal recognition particle 54 kDa 82.44(n)    BC044991.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc558422 similar to signal recognition particle 54 kDa 80.18(n)   393963  BC045474.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Srp54k1 , 3 SRP-dependent, co-translational
    membrane targeting more3
    Signal recognition particle protein 54k1
    77(a)3
    66.93(n)1
    77.11(a)1
      64C93
    385931  NM_079207.31  NP_523931.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F21D5.71 Protein F21D5.7 68.15(n)
    72.41(a)
      259584  NM_069106.3  NP_501507.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SRP54(YPR088C)4
    SRP541
    Signal recognition particle (SRP) subunit (homolog more4
    Srp54p1
    57.4(n)1
    51.12(a)1
      16(713028-711403)4
    8562031, 4  NP_015413.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G489001 signal recognition particle subunit SRP54 61.77(n)
    58.57(a)
      841312  NM_103783.1  NP_564535.1 
    rice
    (Oryza sativa)
    Liliopsida AB114831.12   -- 77.41(n)    AB114831.1 


    ENSEMBL Gene Tree for SRP54 (if available)
    TreeFam Gene Tree for SRP54 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/936 SNPs in SRP54 are shown (see all 936)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1852257511,2
    --35453889(+) TTTTAA/GTAGAG 2 -- int10--------
    rs1901233521,2
    --35454006(+) CCCTGC/TCTAAA 2 -- int10--------
    rs1928542561,2
    --35454019(+) TTATTC/TTTTAG 2 -- int10--------
    rs1445985701,2
    --35454073(+) TTGCAA/GACTCA 2 -- int10--------
    rs347898361,2
    C--35454115(+) CTTCC-/TTTTTT 2 -- int13Minor allele frequency- T:0.17NA CSA 6
    rs1850117871,2
    --35454282(+) CTGTAA/GTCCCA 2 -- int10--------
    rs10284471,2
    C,F,A,H--35454396(+) TAGCCA/GGGCTT 2 -- int19Minor allele frequency- G:0.49NA WA CSA EA 370
    rs726806301,2
    C,F--35454408(+) GTGGCG/ACCGCC 2 -- int11Minor allele frequency- A:0.03NA 120
    rs1128886531,2
    F--35454411(+) GCGCCG/ACCTGT 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs1426050141,2
    --35454439(+) GGGATA/GATGAA 2 -- int10--------

    HapMap Linkage Disequilibrium report for SRP54 (35451163 - 35498773 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/15 variations for SRP54 (see all 15):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1009559CNV Insertion20482838
    esv1401960CNV Insertion17803354
    nsv901615CNV Loss21882294
    dgv1871n71CNV Loss21882294
    nsv1239CNV Loss18451855
    dgv1870n71CNV Loss21882294
    nsv901602CNV Loss21882294
    nsv901614CNV Loss21882294
    nsv901607CNV Loss21882294
    nsv901610CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604857    OMIM disorders: --

    2 diseases for SRP54:    About MalaCards
    polyclonal hypergammaglobulinemia    pneumonia

    1 disease from the University of Copenhagen DISEASES database for SRP54:
    Polyclonal hypergammaglobulinemia

    SRP54 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SRP54
    Human Genome Epidemiology (HuGE) Navigator: SRP54 (1 document)

    Export disorders for SRP54 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SRP54 gene, integrated from 9 sources (see all 63):
    (articles sorted by number of sources associating them with SRP54)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence of the highly conserved gene encoding the human 54kDa subunit of signal recognition particle. (PubMed id 8722571)1, 2, 3 Patel S. and Austen B. (1996)
    2. Protein SRP54 of human signal recognition particle: cloning, expression, and comparative analysis of functional sites. (PubMed id 9511762)1, 2, 9 Gowda K.... Zwieb C. (1998)
    3. Induced structural changes of 7SL RNA during the assembly of human signal recognition particle. (PubMed id 12244299)1, 2, 9 Kuglstatter A.... Nagai K. (2002)
    4. Crystal structure of the conserved subdomain of human protein SRP54M at 2.1 A resolution: evidence for the mechanism of signal peptide binding. (PubMed id 10497032)1, 2, 9 Clemons W.M. Jr.... Ramakrishnan V. (1999)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    6. Human RNPS1 and its associated factors: a versatile alternative pre- mRNA splicing regulator in vivo. (PubMed id 14729963)1, 2 Sakashita E.... Mayeda A. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Assembly of the human signal recognition particle (SRP): overlap of regions required for binding of protein SRP54 and assembly control. (PubMed id 11680843)1, 9 Yin J....Zwieb C. (2001)
    9. Binding site of the M-domain of human protein SRP54 determined by systematic site-directed mutagenesis of signal recognition particle RNA. (PubMed id 9016569)1, 9 Gowda K....Zwieb C. (1997)
    10. Implication of the SMN complex in the biogenesis and s teady state level of the signal recognition particle. (PubMed id 23221635)1 Piazzon N....Massenet S. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6729 HGNC: 11301 AceView: SRP54 Ensembl:ENSG00000100883 euGenes: HUgn6729
    ECgene: SRP54 Kegg: 6729 H-InvDB: SRP54

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SRP54 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Signal_recognition_particle

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SRP54 gene:
    Search GeneIP for patents involving SRP54

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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