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Aliases for SRP54 Gene

Aliases for SRP54 Gene

  • Signal Recognition Particle 54kDa 2 3 5
  • Signal Recognition Particle 54kD 2

External Ids for SRP54 Gene

Previous GeneCards Identifiers for SRP54 Gene

  • GC14P032830
  • GC14P029239
  • GC14P033442
  • GC14P034521
  • GC14P035452
  • GC14P015564

Summaries for SRP54 Gene

GeneCards Summary for SRP54 Gene

SRP54 (Signal Recognition Particle 54kDa) is a Protein Coding gene. Among its related pathways are Protein export and Gene Expression. GO annotations related to this gene include poly(A) RNA binding and GTPase activity.

UniProtKB/Swiss-Prot for SRP54 Gene

  • Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRP54 Gene

Genomics for SRP54 Gene

Regulatory Elements for SRP54 Gene

Enhancers for SRP54 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SRP54 on UCSC Golden Path with GeneCards custom track

Promoters for SRP54 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SRP54 on UCSC Golden Path with GeneCards custom track

Genomic Location for SRP54 Gene

Chromosome:
14
Start:
34,981,957 bp from pter
End:
35,029,567 bp from pter
Size:
47,611 bases
Orientation:
Plus strand

Genomic View for SRP54 Gene

Genes around SRP54 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRP54 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRP54 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRP54 Gene

Proteins for SRP54 Gene

  • Protein details for SRP54 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61011-SRP54_HUMAN
    Recommended name:
    Signal recognition particle 54 kDa protein
    Protein Accession:
    P61011
    Secondary Accessions:
    • B2R759
    • B4DUW6
    • P13624

    Protein attributes for SRP54 Gene

    Size:
    504 amino acids
    Molecular mass:
    55705 Da
    Quaternary structure:
    • Signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. Interacts with RNPS1.

    Three dimensional structures from OCA and Proteopedia for SRP54 Gene

    Alternative splice isoforms for SRP54 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRP54 Gene

Proteomics data for SRP54 Gene at MOPED

Post-translational modifications for SRP54 Gene

  • Ubiquitination at Lys 311, Lys 321, Lys 426, Lys 448, Lys 457, and Lys 464
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for SRP54 Gene

Domains & Families for SRP54 Gene

Suggested Antigen Peptide Sequences for SRP54 Gene

Graphical View of Domain Structure for InterPro Entry

P61011

UniProtKB/Swiss-Prot:

SRP54_HUMAN :
  • Has a two domain structure: the G-domain binds GTP; the M-domain binds the 7S RNA in presence of SRP19 and also binds the signal sequence.
  • Belongs to the GTP-binding SRP family. SRP54 subfamily.
Domain:
  • Has a two domain structure: the G-domain binds GTP; the M-domain binds the 7S RNA in presence of SRP19 and also binds the signal sequence.
Family:
  • Belongs to the GTP-binding SRP family. SRP54 subfamily.
genes like me logo Genes that share domains with SRP54: view

No data available for Gene Families for SRP54 Gene

Function for SRP54 Gene

Molecular function for SRP54 Gene

UniProtKB/Swiss-Prot Function:
Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein).

Gene Ontology (GO) - Molecular Function for SRP54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008144 drug binding IDA 18089836
genes like me logo Genes that share ontologies with SRP54: view
genes like me logo Genes that share phenotypes with SRP54: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SRP54 Gene

Localization for SRP54 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRP54 Gene

Nucleus speckle. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRP54 Gene COMPARTMENTS Subcellular localization image for SRP54 gene
Compartment Confidence
cytosol 5
nucleus 5
chloroplast 2
endoplasmic reticulum 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SRP54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with SRP54: view

Pathways & Interactions for SRP54 Gene

genes like me logo Genes that share pathways with SRP54: view

Pathways by source for SRP54 Gene

1 KEGG pathway for SRP54 Gene

Gene Ontology (GO) - Biological Process for SRP54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with SRP54: view

No data available for SIGNOR curated interactions for SRP54 Gene

Drugs & Compounds for SRP54 Gene

(1) Drugs for SRP54 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(3) Additional Compounds for SRP54 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SRP54: view

Transcripts for SRP54 Gene

Unigene Clusters for SRP54 Gene

Signal recognition particle 54kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SRP54 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^
SP1: - - -
SP2:
SP3: -
SP4: - - -
SP5: - -
SP6: - - -
SP7:

ExUns: 19 ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for SRP54 Gene

GeneLoc Exon Structure for
SRP54
ECgene alternative splicing isoforms for
SRP54

Expression for SRP54 Gene

mRNA expression in normal human tissues for SRP54 Gene

Protein differential expression in normal tissues from HIPED for SRP54 Gene

This gene is overexpressed in Pancreas (12.2) and Lymph node (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SRP54 Gene



SOURCE GeneReport for Unigene cluster for SRP54 Gene Hs.167535

genes like me logo Genes that share expression patterns with SRP54: view

Protein tissue co-expression partners for SRP54 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SRP54 Gene

Orthologs for SRP54 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SRP54 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SRP54 35
  • 95.24 (n)
  • 100 (a)
SRP54 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRP54 35
  • 95.7 (n)
  • 100 (a)
SRP54 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srp54b 35
  • 92.2 (n)
  • 99.8 (a)
Srp54b 16
Srp54a 36
  • 100 (a)
OneToMany
Srp54b 36
  • 100 (a)
OneToMany
Srp54c 36
  • 99 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia SRP54 35
  • 100 (n)
  • 100 (a)
SRP54 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Srp54a 35
  • 91.67 (n)
  • 99.6 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 100 (a)
OneToMany
-- 36
  • 100 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SRP54 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves SRP54 35
  • 86.97 (n)
  • 98.81 (a)
SRP54 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 99 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
-- 36
  • 96 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75926 35
srp54 35
  • 82.41 (n)
  • 96.83 (a)
African clawed frog
(Xenopus laevis)
Amphibia srp54-prov 35
zebrafish
(Danio rerio)
Actinopterygii srp54 35
  • 79.83 (n)
  • 96.03 (a)
zgc55842 35
srp54 36
  • 96 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10862 35
fruit fly
(Drosophila melanogaster)
Insecta Srp54k 37
  • 77 (a)
Srp54k 35
  • 66.93 (n)
  • 77.11 (a)
Srp54k 36
  • 76 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004610 35
  • 68.86 (n)
  • 79.84 (a)
worm
(Caenorhabditis elegans)
Secernentea F21D5.7 35
  • 68.15 (n)
  • 72.41 (a)
F21D5.7 36
  • 72 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR041W 35
  • 52.92 (n)
  • 52.22 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D09020g 35
  • 56.88 (n)
  • 52.43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SRP54 35
  • 57.54 (n)
  • 51.12 (a)
SRP54 36
  • 47 (a)
OneToOne
SRP54 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G48900 35
  • 61.77 (n)
  • 58.57 (a)
soybean
(Glycine max)
eudicotyledons Gma.1605 35
barley
(Hordeum vulgare)
Liliopsida Hv.49 35
rice
(Oryza sativa)
Liliopsida Os01g0772800 35
  • 58.33 (n)
  • 59.15 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15538 35
bread mold
(Neurospora crassa)
Ascomycetes NCU09696 35
  • 57.26 (n)
  • 57.47 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes srp54 35
  • 59.27 (n)
  • 56.66 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 71 (a)
OneToOne
Species with no ortholog for SRP54:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRP54 Gene

ENSEMBL:
Gene Tree for SRP54 (if available)
TreeFam:
Gene Tree for SRP54 (if available)

Paralogs for SRP54 Gene

No data available for Paralogs for SRP54 Gene

Variants for SRP54 Gene

Sequence variations from dbSNP and Humsavar for SRP54 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs2747010 -- 35,009,354(+) CACAT(A/G)TTCTT intron-variant
rs7141292 -- 34,993,700(+) TAATT(A/T)ATTTA intron-variant
rs7141293 -- 34,993,704(+) TTATT(A/T)ATTTA intron-variant
rs7494619 -- 35,027,892(+) ATGGT(C/T)TTCAA intron-variant
rs8017225 -- 35,000,843(+) TGAAT(A/G)TTGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRP54 Gene

Variant ID Type Subtype PubMed ID
nsv483012 CNV Complex 15286789
nsv901602 CNV Loss 21882294
dgv1870n71 CNV Loss 21882294
nsv901606 CNV Loss 21882294
nsv901607 CNV Loss 21882294
dgv1871n71 CNV Loss 21882294
nsv901610 CNV Loss 21882294
nsv901611 CNV Gain 21882294
nsv901612 CNV Gain+Loss 21882294
esv993561 OTHER Inversion 20482838
esv1401960 CNV Insertion 17803354
nsv1239 CNV Loss 18451855
esv1009559 CNV Insertion 20482838
nsv901614 CNV Loss 21882294
nsv901615 CNV Loss 21882294

Variation tolerance for SRP54 Gene

Residual Variation Intolerance Score: 24.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRP54 Gene

HapMap Linkage Disequilibrium report
SRP54

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRP54 Gene

Disorders for SRP54 Gene

Relevant External Links for SRP54

Genetic Association Database (GAD)
SRP54
Human Genome Epidemiology (HuGE) Navigator
SRP54
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRP54

No disorders were found for SRP54 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRP54 Gene

Publications for SRP54 Gene

  1. Sequence of the highly conserved gene encoding the human 54kDa subunit of signal recognition particle. (PMID: 8722571) Patel S. … Austen B. (DNA Seq. 1996) 2 3 4 67
  2. Induced structural changes of 7SL RNA during the assembly of human signal recognition particle. (PMID: 12244299) Kuglstatter A. … Nagai K. (Nat. Struct. Biol. 2002) 3 23
  3. Assembly of the human signal recognition particle (SRP): overlap of regions required for binding of protein SRP54 and assembly control. (PMID: 11680843) Yin J. … Zwieb C. (RNA 2001) 3 23
  4. Crystal structure of the conserved subdomain of human protein SRP54M at 2.1 A resolution: evidence for the mechanism of signal peptide binding. (PMID: 10497032) Clemons W.M. Jr. … Ramakrishnan V. (J. Mol. Biol. 1999) 3 23
  5. Protein SRP54 of human signal recognition particle: cloning, expression, and comparative analysis of functional sites. (PMID: 9511762) Gowda K. … Zwieb C. (Gene 1998) 3 23

Products for SRP54 Gene

Sources for SRP54 Gene

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