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SRP54 Gene

protein-coding   GIFtS: 63
GCID: GC14P035452

Signal Recognition Particle 54kDa

(Previous name: signal recognition particle 54kD)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Signal Recognition Particle 54kDa1 2
Signal Recognition Particle 54kD1
Signal Recognition Particle 54 KDa Protein2

External Ids:    HGNC: 113011   Entrez Gene: 67292   Ensembl: ENSG000001008837   OMIM: 6048575   UniProtKB: P610113   

Export aliases for SRP54 gene to outside databases

Previous GC identifers: GC14P032830 GC14P029239 GC14P033442 GC14P034521 GC14P015564


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SRP54 Gene:
SRP54 (signal recognition particle 54kDa) is a protein-coding gene. Diseases associated with SRP54 include polyclonal hypergammaglobulinemia, and brain cancer. GO annotations related to this gene include drug binding and GTP binding.

UniProtKB/Swiss-Prot: SRP54_HUMAN, P61011
Function: Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers
them to TRAM (translocating chain-associating membrane protein)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SRP54 gene promoter:
         HOXA9   HOXA9B   LHX3b/Lhx3b   p53   Meis-1b   RORalpha1   LHX3a/Lhx3a   c-Jun   Msx-1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSRP54 promoter sequence
   Search Chromatin IP Primers for SRP54

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SRP54


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q13.2   Ensembl cytogenetic band:  14q13.2   HGNC cytogenetic band: 14q13.2

SRP54 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRP54 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P035452:  view genomic region     (about GC identifiers)

Start:
35,451,163 bp from pter      End:
35,498,773 bp from pter
Size:
47,611 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SRP54_HUMAN, P61011 (See protein sequence)
Recommended Name: Signal recognition particle 54 kDa protein  
Size: 504 amino acids; 55705 Da
Subunit: Signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits:
SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. Interacts with RNPS1
2 PDB 3D structures from and Proteopedia for SRP54:
1MFQ (3D)        1QB2 (3D)    
Secondary accessions: B2R759 B4DUW6 P13624
Alternative splicing: 2 isoforms:  P61011-1   P61011-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SRP54: NX_P61011

Explore proteomics data for SRP54 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys50, Lys311, Lys321, Lys426, Lys448, Lys457, Lys464
  • Modification sites at PhosphoSitePlus

  • See SRP54 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001139754.1  NP_003127.1  

    ENSEMBL proteins: 
     ENSP00000451818   ENSP00000451037   ENSP00000451647   ENSP00000451775   ENSP00000451313  
     ENSP00000216774   ENSP00000440629  
    Reactome Protein details: P61011

    SRP54 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for SRP54


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR013822 Signal_recog_particl_SRP54_hlx
     IPR004125 Signal_recog_particle_SRP54_M
     IPR027417 P-loop_NTPase
     IPR006325 SRP54_euk
     IPR003593 AAA+_ATPase

    Graphical View of Domain Structure for InterPro Entry P61011

    ProtoNet protein and cluster: P61011

    1 Blocks protein domain: IPB000897 GTP-binding signal recognition particle (SRP54) G-domain

    UniProtKB/Swiss-Prot: SRP54_HUMAN, P61011
    Domain: Has a two domain structure: the G-domain binds GTP; the M-domain binds the 7S RNA in presence of SRP19 and
    also binds the signal sequence
    Similarity: Belongs to the GTP-binding SRP family. SRP54 subfamily


    SRP54 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRP54_HUMAN, P61011
    Function: Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers
    them to TRAM (translocating chain-associating membrane protein)

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0003924contributes to GTPase activity IDA8247130
    GO:0005525GTP binding IDA8622769
    GO:0008144drug binding IDA18089836
    GO:00083127S RNA binding IDA18089836
         
    SRP54 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SRP54:
     Decreased influenza A virus in  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SRP54
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    miRNA
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    hsa-mir-423-5p (MIRT038146)

    Block miRNA regulation of human, mouse, rat SRP54 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate SRP54:
    hsa-miR-3910 hsa-miR-545 hsa-miR-4282
    SwitchGear 3'UTR luciferase reporter plasmidSRP54 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SRP54 (NM_003136)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRP54
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRP54

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRP54


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SRP54_HUMAN, P61011: Nucleus speckle. Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    chloroplast2
    endoplasmic reticulum2
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA18089836
    GO:0005730NOT nucleolus IDA10618370
    GO:0005737cytoplasm IDA--
    GO:0005786signal recognition particle, endoplasmic reticulum targeting IDA18089836
    GO:0005829cytosol TAS--

    SRP54 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SRP54 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Influenza Viral RNA Transcription and Replication
    SRP-dependent cotranslational protein targeting to membrane0.83
    Translation0.82
    2mRNA Splicing - Major Pathway
    mRNA processing0.44
    3Gene Expression
    Gene Expression0.40
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    5Protein export
    Protein export

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SRP54
        mRNA processing

    1 Reactome Pathway for SRP54
        SRP-dependent cotranslational protein targeting to membrane


    1 Kegg Pathway  (Kegg details for SRP54):
        Protein export


    SRP54 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SRP54
    Interactions:

        GeneGlobe Interaction Network for SRP54

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SRP54 (P610112, 3 ENSP000002167744) via UniProtKB, MINT, STRING, and/or I2D (see all 954)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SRP19P091322, 3, ENSP000002829994MINT-7945693 I2D: score=2 STRING: ENSP00000282999
    CCT2P783712, 3MINT-7945693 MINT-7947479 I2D: score=1 
    CCT3P493682, 3MINT-7945693 MINT-7947479 I2D: score=1 
    CCT5P486432, 3MINT-7945693 MINT-7947479 I2D: score=1 
    CCT6AP402272, 3MINT-7945693 MINT-7947479 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process IDA8247130
    GO:0006412translation TAS--
    GO:0006614SRP-dependent cotranslational protein targeting to membrane TAS--
    GO:0006616SRP-dependent cotranslational protein targeting to membrane, translocation ISS--
    GO:0006617SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition ISS--

    SRP54 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SRP54

    1 HMDB Compound for SRP54    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    3 Novoseek inferred chemical compound relationships for SRP54 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    preprolactin 86.2 2 1314169 (1)
    gdp 45.2 1 11566135 (1)
    gtp 40.4 7 7803856 (4), 9182758 (2)



    SRP54 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SRP54 gene (2 alternative transcripts): 
    NM_001146282.1  NM_003136.3  

    Unigene Cluster for SRP54:

    Signal recognition particle 54kDa
    Hs.167535  [show with all ESTs]
    Unigene Representative Sequence: NM_003136
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000556994(uc001wso.3 uc010tpp.2 uc010tpq.2) ENST00000554803
    ENST00000555746 ENST00000553544 ENST00000555317 ENST00000555557 ENST00000556380
    ENST00000555535 ENST00000553923 ENST00000556445 ENST00000556992 ENST00000216774
    ENST00000546080
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate SRP54:
    hsa-miR-3910 hsa-miR-545 hsa-miR-4282
    SwitchGear 3'UTR luciferase reporter plasmidSRP54 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): SRP54 (NM_003136)
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      QuantiTect SYBR Green Assays in human, mouse, rat SRP54
      QuantiFast Probe-based Assays in human, mouse, rat SRP54

    Additional mRNA sequence: 

    AK293319.1 AK300824.1 AK312853.1 BC000652.2 BC003389.1 U51920.1 

    17 DOTS entries:

    DT.100760554  DT.114758  DT.120752967  DT.91983420  DT.100707312  DT.40239500  DT.100837892  DT.114756 
    DT.100770224  DT.100837891  DT.91801229  DT.99927758  DT.100808302  DT.100837895  DT.95089736  DT.95238783 
    DT.99982255 

    Selected AceView cDNA sequences (see all 216):

    BG529997 BX408887 BC000652 BQ961567 BM461572 CD557634 AI921094 BM728649 
    BU069207 CA432262 CN478830 BQ269901 CB153419 CA417580 BX460685 BM312827 
    BP340982 NM_003136 AI364453 AA079666 AA827709 BI966684 BM930127 BQ064739 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SRP54 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^
    SP1:                                      -                                   -                                                                       -         
    SP2:                                                                                                                                                            
    SP3:                                                                          -                                                                                 
    SP4:        -     -                       -                                                                                                                     
    SP5:                          -           -                                                                                                                     

    ExUns: 19 ^ 20
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for SRP54

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SRP54 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGTAAAATT
    SRP54 Expression
    About this image

    SRP54 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SRP54 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.167535
        Custom PCR Arrays for SRP54
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRP54

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SRP54 gene from Selected species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srp54a5
    Srp54b1
    signal recognition particle 54A5
    signal recognition particle 54B1
    92.2(n)1
    99.8(a)1
      12 (23.86 cM)5
    6651551  NM_001100109.11  NP_001093579.11 
     550892025 
    chicken
    (Gallus gallus)
    Aves SRP541 signal recognition particle 54kDa 86.97(n)
    98.81(a)
      423322  XM_421238.4  XP_421238.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    99(a)
    96(a)
    (see all 3)
    many → 1
    many → 1
    (see all 3)
    2(54574067-54588250)
    AAWZ02039108(1603-9454)
    African clawed frog
    (Xenopus laevis)
    Amphibia srp54-prov2 signal recognition particle 54 kDa 82.44(n)    BC044991.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc558422 similar to signal recognition particle 54 kDa 80.18(n)   393963  BC045474.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Srp54k1 , 3 SRP-dependent, co-translational
    membrane targeting more3
    Signal recognition particle protein 54k1
    77(a)3
    66.93(n)1
    77.11(a)1
      64C93
    385931  NM_079207.41  NP_523931.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F21D5.71 F21D5.7 68.15(n)
    72.41(a)
      259584  NM_069106.4  NP_501507.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SRP54(YPR088C)4
    SRP541
    Signal recognition particle (SRP) subunit (homolog more4
    SRP541
    57.54(n)1
    51.12(a)1
      16(713028-711403)4
    8562031, 4  NP_015413.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G489001 AT1G48900 61.77(n)
    58.57(a)
      841312  NM_103783.1  NP_564535.1 
    rice
    (Oryza sativa)
    Liliopsida AB114831.12   -- 77.41(n)    AB114831.1 


    ENSEMBL Gene Tree for SRP54 (if available)
    TreeFam Gene Tree for SRP54 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SRP54 (see all 936)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1852257511,2
    --35453889(+) TTTTAA/GTAGAG 2 -- int10--------
    rs1901233521,2
    --35454006(+) CCCTGC/TCTAAA 2 -- int10--------
    rs1928542561,2
    --35454019(+) TTATTC/TTTTAG 2 -- int10--------
    rs1445985701,2
    --35454073(+) TTGCAA/GACTCA 2 -- int10--------
    rs347898361,2
    C--35454115(+) CTTCC-/TTTTTT 2 -- int13Minor allele frequency- T:0.17NA CSA 6
    rs1850117871,2
    --35454282(+) CTGTAA/GTCCCA 2 -- int10--------
    rs10284471,2
    C,F,A,H--35454396(+) TAGCCA/GGGCTT 2 -- int19Minor allele frequency- G:0.49NA WA CSA EA 370
    rs726806301,2
    C,F--35454408(+) GTGGCG/ACCGCC 2 -- int11Minor allele frequency- A:0.03NA 120
    rs1128886531,2
    F--35454411(+) GCGCCG/ACCTGT 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs1426050141,2
    --35454439(+) GGGATA/GATGAA 2 -- int10--------

    HapMap Linkage Disequilibrium report for SRP54 (35451163 - 35498773 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SRP54 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1009559CNV Insertion20482838
    esv1401960CNV Insertion17803354
    nsv901615CNV Loss21882294
    dgv1871n71CNV Loss21882294
    nsv1239CNV Loss18451855
    dgv1870n71CNV Loss21882294
    nsv901602CNV Loss21882294
    nsv901614CNV Loss21882294
    nsv901607CNV Loss21882294
    nsv901610CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SRP54
    DNA2.0 Custom Variant and Variant Library Synthesis for SRP54

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604857    OMIM disorders: --

    5 diseases for SRP54:    About MalaCards
    polyclonal hypergammaglobulinemia    brain cancer    pneumonia    hiv-1
    malaria

    1 disease from the University of Copenhagen DISEASES database for SRP54:
    Polyclonal hypergammaglobulinemia

    SRP54 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SRP54
    Human Genome Epidemiology (HuGE) Navigator: SRP54 (1 document)

    Export disorders for SRP54 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SRP54 gene, integrated from 10 sources (see all 65):
    (articles sorted by number of sources associating them with SRP54)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence of the highly conserved gene encoding the human 54kDa subunit of signal recognition particle. (PubMed id 8722571)1, 2, 3 Patel S. and Austen B. (DNA Seq. 1996)
    2. Protein SRP54 of human signal recognition particle: cloning, expression, and comparative analysis of functional sites. (PubMed id 9511762)1, 2, 9 Gowda K.... Zwieb C. (Gene 1998)
    3. Induced structural changes of 7SL RNA during the assembly of human signal recognition particle. (PubMed id 12244299)1, 2, 9 Kuglstatter A.... Nagai K. (Nat. Struct. Biol. 2002)
    4. Crystal structure of the conserved subdomain of human protein SRP54M at 2.1 A resolution: evidence for the mechanism of signal peptide binding. (PubMed id 10497032)1, 2, 9 Clemons W.M. Jr.... Ramakrishnan V. (J. Mol. Biol. 1999)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Human RNPS1 and its associated factors: a versatile alternative pre- mRNA splicing regulator in vivo. (PubMed id 14729963)1, 2 Sakashita E.... Mayeda A. (Mol. Cell. Biol. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Assembly of the human signal recognition particle (SRP): overlap of regions required for binding of protein SRP54 and assembly control. (PubMed id 11680843)1, 9 Yin J....Zwieb C. (RNA 2001)
    9. Binding site of the M-domain of human protein SRP54 determined by systematic site-directed mutagenesis of signal recognition particle RNA. (PubMed id 9016569)1, 9 Gowda K....Zwieb C. (Nucleic Acids Res. 1997)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6729 HGNC: 11301 AceView: SRP54 Ensembl:ENSG00000100883 euGenes: HUgn6729
    ECgene: SRP54 Kegg: 6729 H-InvDB: SRP54

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SRP54 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Signal_recognition_particle

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SRP54 gene:
    Search GeneIP for patents involving SRP54

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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