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Aliases for SRP54 Gene

Aliases for SRP54 Gene

  • Signal Recognition Particle 54 2 3 5
  • Signal Recognition Particle 54kDa 2

External Ids for SRP54 Gene

Previous GeneCards Identifiers for SRP54 Gene

  • GC14P032830
  • GC14P029239
  • GC14P033442
  • GC14P034521
  • GC14P035452
  • GC14P015564

Summaries for SRP54 Gene

GeneCards Summary for SRP54 Gene

SRP54 (Signal Recognition Particle 54) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include poly(A) RNA binding and GTPase activity.

UniProtKB/Swiss-Prot for SRP54 Gene

  • Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRP54 Gene

Genomics for SRP54 Gene

Regulatory Elements for SRP54 Gene

Enhancers for SRP54 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G034980 1.2 ENCODE 26.3 +0.4 400 3.9 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 SRP54 EAPP FAM177A1 PSMA6 PPP2R3C RPS19P3 BAZ1A NFKBIA SRP54-AS1
GH14G035330 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +355.0 354984 12.3 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 PSMA6 NFKBIA EAPP RPS19P3 PPP2R3C BAZ1A FAM177A1 SRP54 QRSL1P3 LOC644584
GH14G034017 1.4 Ensembl ENCODE dbSUPER 10.7 -963.0 -963011 2.2 TBP ZNF354C ZNF143 ZNF207 KLF7 ZNF202 ZNF680 SP3 ZBTB11 ZNF426 EAPP RPS19P3 SRP54 EGLN3-AS1 LOC105370446
GH14G035284 1.8 FANTOM5 Ensembl ENCODE dbSUPER 5.7 +304.8 304814 5.1 PKNOX1 TBL1XR1 BMI1 RAD21 YY1 RARA EGR1 FOS RELB ETV6 NFKBIA BAZ1A PSMA6 FAM177A1 PPP2R3C SRP54 GC14P035292 GC14P035293
GH14G034872 1.4 ENCODE dbSUPER 6.5 -107.6 -107564 4.2 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC ENSG00000258738 PPP2R3C FAM177A1 SRP54 IGBP1P1 KIAA0391 BAZ1A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SRP54 on UCSC Golden Path with GeneCards custom track

Promoters for SRP54 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000067616 543 3001 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3

Genomic Location for SRP54 Gene

Chromosome:
14
Start:
34,981,957 bp from pter
End:
35,029,567 bp from pter
Size:
47,611 bases
Orientation:
Plus strand

Genomic View for SRP54 Gene

Genes around SRP54 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRP54 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRP54 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRP54 Gene

Proteins for SRP54 Gene

  • Protein details for SRP54 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61011-SRP54_HUMAN
    Recommended name:
    Signal recognition particle 54 kDa protein
    Protein Accession:
    P61011
    Secondary Accessions:
    • B2R759
    • B4DUW6
    • P13624

    Protein attributes for SRP54 Gene

    Size:
    504 amino acids
    Molecular mass:
    55705 Da
    Quaternary structure:
    • Signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. Interacts with RNPS1.

    Three dimensional structures from OCA and Proteopedia for SRP54 Gene

    Alternative splice isoforms for SRP54 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRP54 Gene

Post-translational modifications for SRP54 Gene

  • Ubiquitination at posLast=311311, posLast=321321, posLast=426426, isoforms=2448, Lys457, and isoforms=2464
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SRP54 Gene

Domains & Families for SRP54 Gene

Suggested Antigen Peptide Sequences for SRP54 Gene

Graphical View of Domain Structure for InterPro Entry

P61011

UniProtKB/Swiss-Prot:

SRP54_HUMAN :
  • Has a two domain structure: the G-domain binds GTP; the M-domain binds the 7S RNA in presence of SRP19 and also binds the signal sequence.
  • Belongs to the GTP-binding SRP family. SRP54 subfamily.
Domain:
  • Has a two domain structure: the G-domain binds GTP; the M-domain binds the 7S RNA in presence of SRP19 and also binds the signal sequence.
Family:
  • Belongs to the GTP-binding SRP family. SRP54 subfamily.
genes like me logo Genes that share domains with SRP54: view

No data available for Gene Families for SRP54 Gene

Function for SRP54 Gene

Molecular function for SRP54 Gene

UniProtKB/Swiss-Prot Function:
Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein).

Gene Ontology (GO) - Molecular Function for SRP54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA,IEA 22658674
GO:0003924 contributes_to GTPase activity IDA,IEA 8247130
GO:0005515 protein binding IPI 24965446
GO:0005525 GTP binding IEA,IDA 8622769
GO:0008144 drug binding IDA 18089836
genes like me logo Genes that share ontologies with SRP54: view
genes like me logo Genes that share phenotypes with SRP54: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SRP54 Gene

Localization for SRP54 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRP54 Gene

Nucleus speckle. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRP54 gene
Compartment Confidence
nucleus 5
cytosol 5
endoplasmic reticulum 2
plasma membrane 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SRP54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 18089836
GO:0005730 NOT nucleolus IDA 10618370
GO:0005737 cytoplasm IDA 10618370
GO:0005786 signal recognition particle, endoplasmic reticulum targeting IEA,IDA 18089836
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SRP54: view

Pathways & Interactions for SRP54 Gene

genes like me logo Genes that share pathways with SRP54: view

Pathways by source for SRP54 Gene

1 KEGG pathway for SRP54 Gene

Gene Ontology (GO) - Biological Process for SRP54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS,IEA --
GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation ISS --
GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition ISS --
GO:0042493 response to drug IDA 18089836
GO:0045047 protein targeting to ER IMP 18089836
genes like me logo Genes that share ontologies with SRP54: view

No data available for SIGNOR curated interactions for SRP54 Gene

Drugs & Compounds for SRP54 Gene

(1) Drugs for SRP54 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(3) Additional Compounds for SRP54 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SRP54: view

Transcripts for SRP54 Gene

Unigene Clusters for SRP54 Gene

Signal recognition particle 54kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRP54 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^
SP1: - - -
SP2:
SP3: -
SP4: - - -
SP5: - -
SP6: - - -
SP7:

ExUns: 19 ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for SRP54 Gene

GeneLoc Exon Structure for
SRP54
ECgene alternative splicing isoforms for
SRP54

Expression for SRP54 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SRP54 Gene

Protein differential expression in normal tissues from HIPED for SRP54 Gene

This gene is overexpressed in Pancreas (12.2) and Lymph node (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SRP54 Gene



Protein tissue co-expression partners for SRP54 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SRP54 Gene:

SRP54

SOURCE GeneReport for Unigene cluster for SRP54 Gene:

Hs.167535

Evidence on tissue expression from TISSUES for SRP54 Gene

  • Liver(4.4)
  • Nervous system(4.3)
  • Eye(4.2)
  • Blood(2.5)
genes like me logo Genes that share expression patterns with SRP54: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRP54 Gene

Orthologs for SRP54 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SRP54 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRP54 34 35
  • 100 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 100 (a)
OneToMany
-- 35
  • 100 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Srp54a 35
  • 100 (a)
OneToMany
Srp54c 35
  • 99 (a)
OneToMany
Srp54b 34 16 35
  • 92.2 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SRP54 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRP54 34 35
  • 95.7 (n)
cow
(Bos Taurus)
Mammalia SRP54 34 35
  • 95.24 (n)
rat
(Rattus norvegicus)
Mammalia Srp54a 34
  • 91.67 (n)
chicken
(Gallus gallus)
Aves SRP54 34 35
  • 86.97 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 99 (a)
OneToMany
-- 35
  • 96 (a)
OneToMany
-- 35
  • 85 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia srp54 34
  • 82.41 (n)
MGC75926 34
African clawed frog
(Xenopus laevis)
Amphibia srp54-prov 34
zebrafish
(Danio rerio)
Actinopterygii srp54 34 35
  • 79.83 (n)
zgc55842 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10862 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004610 34
  • 68.86 (n)
fruit fly
(Drosophila melanogaster)
Insecta Srp54k 36 34 35
  • 66.93 (n)
worm
(Caenorhabditis elegans)
Secernentea F21D5.7 34 35
  • 68.15 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SRP54 34 35 37
  • 57.54 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D09020g 34
  • 56.88 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR041W 34
  • 52.92 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G48900 34
  • 61.77 (n)
soybean
(Glycine max)
eudicotyledons Gma.1605 34
rice
(Oryza sativa)
Liliopsida Os01g0772800 34
  • 58.33 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.49 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 71 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes srp54 34
  • 59.27 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU09696 34
  • 57.26 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15538 34
Species where no ortholog for SRP54 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRP54 Gene

ENSEMBL:
Gene Tree for SRP54 (if available)
TreeFam:
Gene Tree for SRP54 (if available)

Paralogs for SRP54 Gene

No data available for Paralogs for SRP54 Gene

Variants for SRP54 Gene

Sequence variations from dbSNP and Humsavar for SRP54 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000021037 -- 35,009,937(+) GAGGT(C/G)AGGAG intron-variant
rs1000021295 -- 35,001,271(+) CTCAG(C/T)CTCCC intron-variant
rs1000385601 -- 34,987,829(+) TTAGA(C/T)TGTGT intron-variant
rs1000461098 -- 34,983,563(+) TTTGT(A/C)GTGCT intron-variant, upstream-variant-2KB
rs1000513180 -- 34,999,945(+) AAGCC(C/T)TTTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRP54 Gene

Variant ID Type Subtype PubMed ID
dgv1867n100 CNV gain 25217958
esv1009559 CNV insertion 20482838
esv1401960 CNV insertion 17803354
esv3581114 CNV loss 25503493
esv3892499 CNV loss 25118596
esv993561 OTHER inversion 20482838
nsv1043801 CNV loss 25217958
nsv1239 CNV deletion 18451855
nsv483012 CNV gain+loss 15286789
nsv564200 CNV gain 21841781
nsv564263 CNV loss 21841781
nsv564264 CNV gain 21841781

Variation tolerance for SRP54 Gene

Residual Variation Intolerance Score: 24.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRP54 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRP54

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRP54 Gene

Disorders for SRP54 Gene

Relevant External Links for SRP54

Genetic Association Database (GAD)
SRP54
Human Genome Epidemiology (HuGE) Navigator
SRP54
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRP54

No disorders were found for SRP54 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRP54 Gene

Publications for SRP54 Gene

  1. Induced structural changes of 7SL RNA during the assembly of human signal recognition particle. (PMID: 12244299) Kuglstatter A. … Nagai K. (Nat. Struct. Biol. 2002) 3 4 22 64
  2. Crystal structure of the conserved subdomain of human protein SRP54M at 2.1 A resolution: evidence for the mechanism of signal peptide binding. (PMID: 10497032) Clemons W.M. Jr. … Ramakrishnan V. (J. Mol. Biol. 1999) 3 4 22 64
  3. Protein SRP54 of human signal recognition particle: cloning, expression, and comparative analysis of functional sites. (PMID: 9511762) Gowda K. … Zwieb C. (Gene 1998) 3 4 22 64
  4. Sequence of the highly conserved gene encoding the human 54kDa subunit of signal recognition particle. (PMID: 8722571) Patel S. … Austen B. (DNA Seq. 1996) 2 3 4 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64

Products for SRP54 Gene

Sources for SRP54 Gene

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