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Aliases for SRP19 Gene

Aliases for SRP19 Gene

  • Signal Recognition Particle 19kDa 2 3
  • Signal Recognition Particle 19kD 2

External Ids for SRP19 Gene

Previous GeneCards Identifiers for SRP19 Gene

  • GC05P111793
  • GC05P112644
  • GC05P112227
  • GC05P112273
  • GC05P112224
  • GC05P112196
  • GC05P107376

Summaries for SRP19 Gene

GeneCards Summary for SRP19 Gene

SRP19 (Signal Recognition Particle 19kDa) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Gene Expression. GO annotations related to this gene include 7S RNA binding. An important paralog of this gene is ENSG00000272869.

UniProtKB/Swiss-Prot for SRP19 Gene

  • Signal-recognition-particle assembly, binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRP19 Gene

Genomics for SRP19 Gene

Genomic Location for SRP19 Gene

Start:
112,861,188 bp from pter
End:
112,893,079 bp from pter
Size:
31,892 bases
Orientation:
Plus strand

Genomic View for SRP19 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SRP19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRP19 Gene

Proteins for SRP19 Gene

  • Protein details for SRP19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09132-SRP19_HUMAN
    Recommended name:
    Signal recognition particle 19 kDa protein
    Protein Accession:
    P09132
    Secondary Accessions:
    • B2R4E9
    • D6RCQ5
    • Q05D77
    • Q96FG6

    Protein attributes for SRP19 Gene

    Size:
    144 amino acids
    Molecular mass:
    16156 Da
    Quaternary structure:
    • Signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.

    Three dimensional structures from OCA and Proteopedia for SRP19 Gene

    Alternative splice isoforms for SRP19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRP19 Gene

Proteomics data for SRP19 Gene at MOPED

Post-translational modifications for SRP19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SRP19 Gene

No data available for DME Specific Peptides for SRP19 Gene

Domains for SRP19 Gene

Protein Domains for SRP19 Gene

Suggested Antigen Peptide Sequences for SRP19 Gene

Graphical View of Domain Structure for InterPro Entry

P09132

UniProtKB/Swiss-Prot:

SRP19_HUMAN :
  • P09132
Family:
  • Belongs to the SRP19 family.
genes like me logo Genes that share domains with SRP19: view

No data available for Gene Families for SRP19 Gene

Function for SRP19 Gene

Molecular function for SRP19 Gene

GENATLAS Biochemistry: signal recognition particle,ribosomal (19kDa)
UniProtKB/Swiss-Prot Function: Signal-recognition-particle assembly, binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP

Gene Ontology (GO) - Molecular Function for SRP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008312 7S RNA binding IDA 17434535
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SRP19: view

Animal Model Products

CRISPR Products

miRNA for SRP19 Gene

miRTarBase miRNAs that target SRP19

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SRP19 Gene

Localization for SRP19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRP19 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRP19 Gene COMPARTMENTS Subcellular localization image for SRP19 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 4
endoplasmic reticulum 2
extracellular 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SRP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA 10618370
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with SRP19: view

Pathways for SRP19 Gene

genes like me logo Genes that share pathways with SRP19: view

Pathways by source for SRP19 Gene

Gene Ontology (GO) - Biological Process for SRP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation TAS --
GO:0006613 cotranslational protein targeting to membrane TAS 1678319
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
GO:0010467 gene expression TAS --
GO:0042493 response to drug IDA 18089836
genes like me logo Genes that share ontologies with SRP19: view

Compounds for SRP19 Gene

(4) PharmGKB related drug/compound annotations for SRP19 Gene

Drug/compound Annotation
citalopram CA
fluoxetine CA
paroxetine CA
sertraline CA
genes like me logo Genes that share compounds with SRP19: view

Transcripts for SRP19 Gene

Unigene Clusters for SRP19 Gene

Signal recognition particle 19kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SRP19

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRP19 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b
SP1: - - - -
SP2: - - -
SP3: -
SP4: - - - - -
SP5: - - -
SP6: -

Relevant External Links for SRP19 Gene

GeneLoc Exon Structure for
SRP19
ECgene alternative splicing isoforms for
SRP19

Expression for SRP19 Gene

mRNA expression in normal human tissues for SRP19 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SRP19 Gene

SOURCE GeneReport for Unigene cluster for SRP19 Gene Hs.637001

genes like me logo Genes that share expressions with SRP19: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SRP19 Gene

Orthologs for SRP19 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SRP19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRP19 35
  • 99.77 (n)
  • 100 (a)
SRP19 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SRP19 35
  • 94.81 (n)
  • 97.78 (a)
SRP19 36
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SRP19 35
  • 90.74 (n)
  • 98.61 (a)
SRP19 36
  • 99 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Srp19 35
  • 89.38 (n)
  • 96.3 (a)
Srp19 16
Srp19 36
  • 97 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 91 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Srp19 35
  • 89.14 (n)
  • 96.3 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 85 (a)
OneToMany
SRP19 35
  • 76.54 (n)
  • 85.19 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 80 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.2367 35
tropical clawed frog
(Silurana tropicalis)
Amphibia srp19 35
  • 65.89 (n)
  • 70.31 (a)
Str.11353 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8854 35
zebrafish
(Danio rerio)
Actinopterygii srp19 35
  • 65.35 (n)
  • 72.44 (a)
srp19 36
  • 70 (a)
OneToMany
wufj65h05 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009948 35
  • 49.25 (n)
  • 46.85 (a)
fruit fly
(Drosophila melanogaster)
Insecta Srp19 35
  • 53.87 (n)
  • 53.57 (a)
Srp19 36
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F37F2.2 35
  • 52.99 (n)
  • 50.43 (a)
F37F2.2 36
  • 46 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC65 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G48160 35
  • 51.28 (n)
  • 48.08 (a)
rice
(Oryza sativa)
Liliopsida Os06g0342100 35
  • 47.12 (n)
  • 46.15 (a)
Species with no ortholog for SRP19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRP19 Gene

ENSEMBL:
Gene Tree for SRP19 (if available)
TreeFam:
Gene Tree for SRP19 (if available)

Paralogs for SRP19 Gene

Paralogs for SRP19 Gene

Pseudogenes.org Pseudogenes for SRP19 Gene

genes like me logo Genes that share paralogs with SRP19: view

Variants for SRP19 Gene

Sequence variations from dbSNP and Humsavar for SRP19 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs7213 -- 112,867,867(+) ACATT(A/T)TGTCC utr-variant-3-prime, intron-variant
rs187073 -- 112,866,194(-) ggttg(C/T)ggtga intron-variant
rs187074 -- 112,866,178(-) gatca(C/T)gccat intron-variant
rs191598 -- 112,866,210(-) gaacc(C/T)gggag intron-variant
rs351767 -- 112,864,401(-) TGCCA(C/T)AGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRP19 Gene

Variant ID Type Subtype PubMed ID
nsv4960 CNV Loss 18451855
esv26872 CNV Loss 19812545
esv2730601 CNV Deletion 23290073
esv2667456 CNV Deletion 23128226

Relevant External Links for SRP19 Gene

HapMap Linkage Disequilibrium report
SRP19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRP19 Gene

Disorders for SRP19 Gene

(1) University of Copenhagen DISEASES for SRP19 Gene

Relevant External Links for SRP19

Genetic Association Database (GAD)
SRP19
genes like me logo Genes that share disorders with SRP19: view

No data available for UniProtKB/Swiss-Prot for SRP19 Gene

Publications for SRP19 Gene

  1. Induced structural changes of 7SL RNA during the assembly of human signal recognition particle. (PMID: 12244299) Kuglstatter A. … Nagai K. (Nat. Struct. Biol. 2002) 3 4 23
  2. Crystal structure of an early protein-RNA assembly complex of the signal recognition particle. (PMID: 11641499) Wild K. … Cusack S. (Science 2001) 3 4 23
  3. Isolation and characterization of a cDNA clone encoding the 19 kDa protein of signal recognition particle (SRP): expression and binding to 7SL RNA. (PMID: 2460823) Lingelbach K. … Dobberstein B. (Nucleic Acids Res. 1988) 2 3 4
  4. Structural insights into the assembly of the human and archaeal signal recognition particles. (PMID: 20179341) Wild K. … Sinning I. (Acta Crystallogr. D 2010) 3 4 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SRP19 Gene

Sources for SRP19 Gene

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