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SRP19 Gene

protein-coding   GIFtS: 59
GCID: GC05P112196

Signal Recognition Particle 19kDa

(Previous name: signal recognition particle 19kD)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Signal Recognition Particle 19kDa1 2
Signal Recognition Particle 19kD1
Signal Recognition Particle 19 KDa Protein2

External Ids:    HGNC: 113001   Entrez Gene: 67282   Ensembl: ENSG000001530377   OMIM: 1821755   UniProtKB: P091323   
ORGUL members:         

Export aliases for SRP19 gene to outside databases

Previous GC identifers: GC05P111793 GC05P112644 GC05P112227 GC05P112273 GC05P112224 GC05P107376


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SRP19 Gene:
SRP19 (signal recognition particle 19kDa) is a protein-coding gene. GO annotations related to this gene include 7S RNA binding. An important paralog of this gene is ENSG00000272869.

UniProtKB/Swiss-Prot: SRP19_HUMAN, P09132
Function: Signal-recognition-particle assembly, binds directly to 7S RNA and mediates binding of the 54 kDa
subunit of the SRP




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the SRP19 gene promoter:
         SREBP-1c   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   POU2F1   HSF2   POU2F1a   FOXJ2 (long isoform)   SEF-1 (1)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSRP19 promoter sequence
   Search Chromatin IP Primers for SRP19

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SRP19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q21-q22   Ensembl cytogenetic band:  5q22.2   HGNC cytogenetic band: 5q21-q22

SRP19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRP19 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P112196:  view genomic region     (about GC identifiers)

Start:
112,196,885 bp from pter      End:
112,228,776 bp from pter
Size:
31,892 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SRP19_HUMAN, P09132 (See protein sequence)
Recommended Name: Signal recognition particle 19 kDa protein  
Size: 144 amino acids; 16156 Da
Subunit: Signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits:
SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9
5 PDB 3D structures from and Proteopedia for SRP19:
1JID (3D)        1MFQ (3D)        1RY1 (3D)        2J37 (3D)        3KTV (3D)    
Secondary accessions: B2R4E9 D6RCQ5 Q05D77 Q96FG6
Alternative splicing: 3 isoforms:  P09132-1   P09132-2   P09132-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SRP19: NX_P09132

Explore proteomics data for SRP19 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SRP19 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001191122.1  NP_001191123.1  NP_001191125.1  NP_001191128.1  NP_003126.1  

    ENSEMBL proteins: 
     ENSP00000424870   ENSP00000282999   ENSP00000425562  
    Reactome Protein details: P09132

    SRP19 Human Recombinant Protein Products:

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    Novus Biologicals SRP19 Lysates
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    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for SRP19
    Cloud-Clone Corp. Proteins for SRP19

     
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    antibodies-online proteins for SRP19 (12 products) 

     
    antibodies-online peptides for SRP19

    SRP19 Antibody Products:

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    antibodies-online antibodies for SRP19 (15 products) 

    SRP19 Assay Products:

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    Cloud-Clone Corp. CLIAs for SRP19
    Search eBioscience for ELISAs for SRP19 
    antibodies-online kits for SRP19 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR002778 Signal_recog_particle_SRP19

    Graphical View of Domain Structure for InterPro Entry P09132

    ProtoNet protein and cluster: P09132

    1 Blocks protein domain: IPB002778 Ribonucleoprotein complex SRP

    UniProtKB/Swiss-Prot: SRP19_HUMAN, P09132
    Similarity: Belongs to the SRP19 family


    Find genes that share domains with SRP19           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRP19_HUMAN, P09132
    Function: Signal-recognition-particle assembly, binds directly to 7S RNA and mediates binding of the 54 kDa
    subunit of the SRP

         Genatlas biochemistry entry for SRP19:
    signal recognition particle,ribosomal (19kDa)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00083127S RNA binding IDA17434535
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with SRP19           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SRP19

    miRNA
    Products:
        
    miRTarBase miRNAs that target SRP19:
    hsa-mir-16-5p (MIRT031967)

    Block miRNA regulation of human, mouse, rat SRP19 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SRP19 (see all 17):
    hsa-miR-498 hsa-miR-607 hsa-miR-513a-5p hsa-miR-1297 hsa-miR-223 hsa-miR-508-5p hsa-miR-2276 hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidSRP19 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SRP19
    Predesigned siRNA for gene silencing in human, mouse, rat SRP19

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for SRP19

    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 5): SRP19 (NM_003135)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRP19
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRP19

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRP19

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12212) for SRP19 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SRP19_HUMAN, P09132: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    mitochondrion4
    endoplasmic reticulum2
    extracellular2
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA10618370
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA--
    GO:0005786signal recognition particle, endoplasmic reticulum targeting IDA18089836

    Find genes that share ontologies with SRP19           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SRP19 About    
    See pathways by source

    SuperPathContained pathways About
    1Influenza Viral RNA Transcription and Replication
    SRP-dependent cotranslational protein targeting to membrane0.83
    Translation0.82
    2Gene Expression
    Gene Expression0.40
    3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    4Protein export
    Protein export


    Find genes that share SuperPaths with SRP19           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SRP19
        SRP-dependent cotranslational protein targeting to membrane


    1 Kegg Pathway  (Kegg details for SRP19):
        Protein export

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SRP19
    Interactions:

        GeneGlobe Interaction Network for SRP19

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SRP19 (P091322, 3 ENSP000002829994) via UniProtKB, MINT, STRING, and/or I2D (see all 668)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SRP54P610112, 3, ENSP000002167744MINT-7945693 I2D: score=2 STRING: ENSP00000216774
    IPO5O004102, 3, ENSP000002615744MINT-7945693 I2D: score=1 STRING: ENSP00000261574
    KPNA1P522942, 3, ENSP000003437014MINT-7945693 I2D: score=1 STRING: ENSP00000343701
    TNPO1Q929733, ENSP000003367124I2D: score=2 STRING: ENSP00000336712
    RPL12P300502, ENSP000003547394MINT-7945693 STRING: ENSP00000354739
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation TAS--
    GO:0006613cotranslational protein targeting to membrane TAS1678319
    GO:0006614SRP-dependent cotranslational protein targeting to membrane TAS--
    GO:0010467gene expression TAS--
    GO:0042493response to drug IDA18089836

    Find genes that share ontologies with SRP19           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SRP19

    4 PharmGKB related drug/compound annotations for SRP19 gene    About this table
    Drug/compound PharmGKB Annotation
    citalopramCA  
    fluoxetineCA  
    paroxetineCA  
    sertralineCA  



    Find genes that share compounds with SRP19           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SRP19 gene (5 alternative transcripts): 
    NM_001204193.1  NM_001204194.1  NM_001204196.1  NM_001204199.1  NM_003135.2  

    Unigene Cluster for SRP19:

    Signal recognition particle 19kDa
    Hs.637001  [show with all ESTs]
    Unigene Representative Sequence: NM_001204199
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000505459(uc003kqc.3 uc021yck.1 uc003kqb.2 uc021ycl.1)
    ENST00000282999 ENST00000515463 ENST00000515755 ENST00000445150 ENST00000506987
    ENST00000504696
    miRNA
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    Block miRNA regulation of human, mouse, rat SRP19 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SRP19 (see all 17):
    hsa-miR-498 hsa-miR-607 hsa-miR-513a-5p hsa-miR-1297 hsa-miR-223 hsa-miR-508-5p hsa-miR-2276 hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidSRP19 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 5): SRP19 (NM_003135)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRP19
    Primer
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    OriGene qPCR primer pairs and template standards for SRP19
    OriGene qSTAR qPCR primer pairs in human, mouse for SRP19
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SRP19
      QuantiTect SYBR Green Assays in human, mouse, rat SRP19
      QuantiFast Probe-based Assays in human, mouse, rat SRP19
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12212) for SRP19 

    Additional mRNA sequence: 

    AK311803.1 BC000186.1 BC010947.1 BC017830.1 BC018669.1 BC104811.1 BC113599.1 D49676.1 
    X12791.1 

    21 DOTS entries:

    DT.91950191  DT.100820426  DT.315795  DT.95274501  DT.75137653  DT.97805081  DT.120809660  DT.99948273 
    DT.97763272  DT.99997971  DT.120809774  DT.75113252  DT.95262946  DT.445527  DT.95274503  DT.120809720 
    DT.100820425  DT.91757898  DT.92018552  DT.120809591  DT.75168549 

    Selected AceView cDNA sequences (see all 445):

    D49676 F05691 F01948 BG108327 AA151217 BM977243 F09958 F12582 
    F06453 BG142221 BQ423807 BF590515 F13412 CA312933 BQ431154 AI831854 
    BM987992 M74088 BU629028 BP360258 BC000186 CB158849 BE256854 CR592658 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SRP19 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b
    SP1:                    -                       -     -     -         
    SP2:                    -                       -     -               
    SP3:                    -                                             
    SP4:                    -     -                 -     -     -         
    SP5:                                            -     -     -         


    ECgene alternative splicing isoforms for SRP19

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SRP19 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGGAGACT
    SRP19 Expression
    About this image

    SRP19 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SRP19 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.637001
        Custom PCR Arrays for SRP19
    Primer
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    OriGene qPCR primer pairs and template standards for SRP19
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    QuantiFast Probe-based Assays in human, mouse, rat SRP19
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRP19

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SRP19 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srp191 , 5 signal recognition particle 191, 5 89.38(n)1
    96.3(a)1
      18 (18.57 cM)5
    663841  NM_025527.31  NP_079803.21 
     343308475 
    chicken
    (Gallus gallus)
    Aves SRP191 signal recognition particle 19kDa 76.54(n)
    85.19(a)
      770061  XM_001233374.3  XP_001233375.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    80(a)
    1 → many
    GL343193.1(7004196-7010117)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.23672 Xenopus laevis transcribed sequence with moderate similarity more 72.25(n)    BJ067378.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj65h052 Danio rerio cDNA clone MGC63961 IMAGE6791908, complete more 68.58(n)    BC053168.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Srp191 Signal recognition particle protein 19 53.87(n)
    53.57(a)
      38815  NM_057787.5  NP_477135.2 
    worm
    (Caenorhabditis elegans)
    Secernentea F37F2.21 F37F2.2 52.99(n)
    50.43(a)
      171711  NM_058454.2  NP_490855.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G481601 AT1G48160 51.28(n)
    48.08(a)
      841235  NM_103712.2  NP_175250.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g03421001 Os06g0342100 47.12(n)
    46.15(a)
      4340957  NM_001064105.1  NP_001057570.1 


    ENSEMBL Gene Tree for SRP19 (if available)
    TreeFam Gene Tree for SRP19 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SRP19 gene
    ENSG000002728692  

    Find genes that share paralogs with SRP19           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SRP19
    PGOHUM00000242110


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SRP19 (see all 454)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs754570891,2
    C,F--112194919(+) ACTAGC/TTAATC 5 -- us2k11Minor allele frequency- T:0.07EA 120
    rs1494984391,2
    --112194989(+) TCAGCA/GCTTGC 5 -- us2k10--------
    rs1874049581,2
    --112195039(+) GGATTA/CTTTCT 5 -- us2k10--------
    rs742944281,2
    C,F--112195140(+) TTGCTC/TGGATT 5 -- us2k12Minor allele frequency- T:0.11WA EA 238
    rs1441561111,2
    --112195188(+) CTTCTA/TTCCAA 5 -- us2k10--------
    rs1918655661,2
    --112195309(+) TTACAA/GCTTGG 5 -- us2k10--------
    rs1837302901,2
    --112195332(+) AAGAGA/GCCTAG 5 -- us2k10--------
    rs773641211,2
    C--112195481(+) AACATC/TGTTGT 5 -- us2k10--------
    rs1486823731,2
    --112195543(+) TTGGTC/TGAACA 5 -- us2k10--------
    rs1866806671,2
    --112195722(+) AGATTC/TCCCTG 5 -- us2k10--------

    HapMap Linkage Disequilibrium report for SRP19 (112196885 - 112228776 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SRP19:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2730601CNV Deletion23290073
    esv2667456CNV Deletion23128226
    nsv4960CNV Loss18451855
    esv26872CNV Loss19812545

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 182175    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for SRP19:
    Familial adenomatous polyposis

    Find genes that share disorders with SRP19           About GenesLikeMe

    Genetic Association Database (GAD): SRP19

    Export disorders for SRP19 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SRP19 gene, integrated from 10 sources (see all 65):
    (articles sorted by number of sources associating them with SRP19)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of a cDNA clone encoding the 19 kDa protein of signal recognition particle (SRP): expression and binding to 7SL RNA. (PubMed id 2460823)1, 2, 3 Lingelbach K.... Dobberstein B. (Nucleic Acids Res. 1988)
    2. Structural insights into the assembly of the human and archaeal signal recognition particles. (PubMed id 20179341)1, 2, 9 Wild K.... Sinning I. (Acta Crystallogr. D 2010)
    3. Induced structural changes of 7SL RNA during the assembly of human signal recognition particle. (PubMed id 12244299)1, 2, 9 Kuglstatter A.... Nagai K. (Nat. Struct. Biol. 2002)
    4. Crystal structure of an early protein-RNA assembly complex of the signal recognition particle. (PubMed id 11641499)1, 2, 9 Wild K.... Cusack S. (Science 2001)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. A threefold RNA-protein interface in the signal recognition particle gates native complex assembly. (PubMed id 17434535)1, 9 Maity T.S. and Weeks K.M. (J. Mol. Biol. 2007)
    7. Binding site of the M-domain of human protein SRP54 determined by systematic site-directed mutagenesis of signal recognition particle RNA. (PubMed id 9016569)1, 9 Gowda K....Zwieb C. (Nucleic Acids Res. 1997)
    8. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    9. Implication of the SMN complex in the biogenesis and steady state level of the signal recognition particle. (PubMed id 23221635)1 Piazzon N....Massenet S. (Nucleic Acids Res. 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6728 HGNC: 11300 AceView: APCandSRP19andU2AF1L1 Ensembl:ENSG00000153037 euGenes: HUgn6728
    ECgene: SRP19 Kegg: 6728 H-InvDB: SRP19

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SRP19 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Signal-recognition_particle

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SRP19 gene:
    Search GeneIP for patents involving SRP19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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