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Aliases for SRP19 Gene

Aliases for SRP19 Gene

  • Signal Recognition Particle 19 2 3
  • Signal Recognition Particle 19kDa 2 5

External Ids for SRP19 Gene

Previous GeneCards Identifiers for SRP19 Gene

  • GC05P111793
  • GC05P112644
  • GC05P112227
  • GC05P112273
  • GC05P112224
  • GC05P112196
  • GC05P107376

Summaries for SRP19 Gene

GeneCards Summary for SRP19 Gene

SRP19 (Signal Recognition Particle 19) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Transport to the Golgi and subsequent modification. GO annotations related to this gene include poly(A) RNA binding and 7S RNA binding. An important paralog of this gene is ENSG00000272869.

UniProtKB/Swiss-Prot for SRP19 Gene

  • Signal-recognition-particle assembly, binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRP19 Gene

Genomics for SRP19 Gene

Regulatory Elements for SRP19 Gene

Enhancers for SRP19 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SRP19 on UCSC Golden Path with GeneCards custom track

Promoters for SRP19 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SRP19 Gene

Chromosome:
5
Start:
112,861,188 bp from pter
End:
112,893,079 bp from pter
Size:
31,892 bases
Orientation:
Plus strand

Genomic View for SRP19 Gene

Genes around SRP19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRP19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRP19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRP19 Gene

Proteins for SRP19 Gene

  • Protein details for SRP19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09132-SRP19_HUMAN
    Recommended name:
    Signal recognition particle 19 kDa protein
    Protein Accession:
    P09132
    Secondary Accessions:
    • B2R4E9
    • D6RCQ5
    • Q05D77
    • Q96FG6

    Protein attributes for SRP19 Gene

    Size:
    144 amino acids
    Molecular mass:
    16156 Da
    Quaternary structure:
    • Signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.

    Three dimensional structures from OCA and Proteopedia for SRP19 Gene

    Alternative splice isoforms for SRP19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRP19 Gene

Post-translational modifications for SRP19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SRP19 Gene

Domains & Families for SRP19 Gene

Protein Domains for SRP19 Gene

Suggested Antigen Peptide Sequences for SRP19 Gene

Graphical View of Domain Structure for InterPro Entry

P09132

UniProtKB/Swiss-Prot:

SRP19_HUMAN :
  • Belongs to the SRP19 family.
Family:
  • Belongs to the SRP19 family.
genes like me logo Genes that share domains with SRP19: view

No data available for Gene Families for SRP19 Gene

Function for SRP19 Gene

Molecular function for SRP19 Gene

GENATLAS Biochemistry:
signal recognition particle,ribosomal (19kDa)
UniProtKB/Swiss-Prot Function:
Signal-recognition-particle assembly, binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.

Gene Ontology (GO) - Molecular Function for SRP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008312 7S RNA binding IDA 17434535
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SRP19: view
genes like me logo Genes that share phenotypes with SRP19: view

Animal Model Products

CRISPR Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SRP19 Gene

Localization for SRP19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRP19 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRP19 Gene COMPARTMENTS Subcellular localization image for SRP19 gene
Compartment Confidence
cytosol 5
mitochondrion 5
nucleus 5
extracellular 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SRP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA 10618370
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0005786 signal recognition particle, endoplasmic reticulum targeting IDA 18089836
genes like me logo Genes that share ontologies with SRP19: view

Pathways & Interactions for SRP19 Gene

genes like me logo Genes that share pathways with SRP19: view

Pathways by source for SRP19 Gene

Gene Ontology (GO) - Biological Process for SRP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006613 cotranslational protein targeting to membrane TAS 1678319
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
GO:0042493 response to drug IDA 18089836
genes like me logo Genes that share ontologies with SRP19: view

No data available for SIGNOR curated interactions for SRP19 Gene

Drugs & Compounds for SRP19 Gene

(4) Drugs for SRP19 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Citalopram Approved Pharma 500
Fluoxetine Approved, Vet_approved Pharma Channel blocker 229
paroxetine Approved, Investigational Pharma Inhibition, Inhibitor 223
sertraline Approved Pharma Inhibition, Inhibitor 290
genes like me logo Genes that share compounds with SRP19: view

Transcripts for SRP19 Gene

Unigene Clusters for SRP19 Gene

Signal recognition particle 19kDa:
Representative Sequences:

CRISPR Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRP19 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b
SP1: - - - -
SP2: - - -
SP3: -
SP4: - - - - -
SP5: - - -
SP6: -

Relevant External Links for SRP19 Gene

GeneLoc Exon Structure for
SRP19
ECgene alternative splicing isoforms for
SRP19

Expression for SRP19 Gene

mRNA expression in normal human tissues for SRP19 Gene

Protein differential expression in normal tissues from HIPED for SRP19 Gene

This gene is overexpressed in Bone (11.8), Pancreas (6.9), Peripheral blood mononuclear cells (6.8), and Lung (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SRP19 Gene



Protein tissue co-expression partners for SRP19 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SRP19 Gene:

SRP19

SOURCE GeneReport for Unigene cluster for SRP19 Gene:

Hs.637001
genes like me logo Genes that share expression patterns with SRP19: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SRP19 Gene

Orthologs for SRP19 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SRP19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRP19 35
  • 100 (a)
OneToOne
SRP19 34
  • 99.77 (n)
  • 100 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 66 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Srp19 35
  • 97 (a)
OneToMany
Srp19 16
Srp19 34
  • 89.38 (n)
  • 96.3 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 91 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SRP19 35
  • 99 (a)
OneToMany
SRP19 34
  • 90.74 (n)
  • 98.61 (a)
cow
(Bos Taurus)
Mammalia SRP19 35
  • 98 (a)
OneToMany
SRP19 34
  • 94.81 (n)
  • 97.78 (a)
rat
(Rattus norvegicus)
Mammalia Srp19 34
  • 89.14 (n)
  • 96.3 (a)
chicken
(Gallus gallus)
Aves -- 35
  • 85 (a)
OneToMany
SRP19 34
  • 76.54 (n)
  • 85.19 (a)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 80 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.2367 34
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11353 34
srp19 34
  • 65.89 (n)
  • 70.31 (a)
zebrafish
(Danio rerio)
Actinopterygii srp19 35
  • 70 (a)
OneToMany
wufj65h05 34
srp19 34
  • 65.35 (n)
  • 72.44 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8854 34
fruit fly
(Drosophila melanogaster)
Insecta Srp19 35
  • 44 (a)
OneToMany
Srp19 34
  • 53.87 (n)
  • 53.57 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009948 34
  • 49.25 (n)
  • 46.85 (a)
worm
(Caenorhabditis elegans)
Secernentea F37F2.2 35
  • 46 (a)
OneToMany
F37F2.2 34
  • 52.99 (n)
  • 50.43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC65 37
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G48160 34
  • 51.28 (n)
  • 48.08 (a)
rice
(Oryza sativa)
Liliopsida Os06g0342100 34
  • 47.12 (n)
  • 46.15 (a)
Species where no ortholog for SRP19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRP19 Gene

ENSEMBL:
Gene Tree for SRP19 (if available)
TreeFam:
Gene Tree for SRP19 (if available)

Paralogs for SRP19 Gene

Paralogs for SRP19 Gene

Pseudogenes.org Pseudogenes for SRP19 Gene

genes like me logo Genes that share paralogs with SRP19: view

Variants for SRP19 Gene

Sequence variations from dbSNP and Humsavar for SRP19 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs17855423 - 112,861,386(+) CTTGC(A/G)CTGCC reference, missense
rs187073 -- 112,866,194(-) ggttg(C/T)ggtga intron-variant
rs187074 -- 112,866,178(-) gatca(C/T)gccat intron-variant
rs191598 -- 112,866,210(-) gaacc(C/T)gggag intron-variant
rs351767 -- 112,864,401(-) TGCCA(C/T)AGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRP19 Gene

Variant ID Type Subtype PubMed ID
esv2667456 CNV deletion 23128226
esv26872 CNV loss 19812545
esv2730601 CNV deletion 23290073
esv3566464 CNV deletion 23714750
esv3606302 CNV loss 21293372
nsv4960 CNV deletion 18451855
nsv599394 CNV gain 21841781
nsv968976 CNV duplication 23825009

Variation tolerance for SRP19 Gene

Residual Variation Intolerance Score: 38.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.22; 4.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRP19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRP19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRP19 Gene

Disorders for SRP19 Gene

Relevant External Links for SRP19

Genetic Association Database (GAD)
SRP19
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRP19

No disorders were found for SRP19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRP19 Gene

Publications for SRP19 Gene

  1. Structural insights into the assembly of the human and archaeal signal recognition particles. (PMID: 20179341) Wild K. … Sinning I. (Acta Crystallogr. D 2010) 3 4 22 65
  2. Induced structural changes of 7SL RNA during the assembly of human signal recognition particle. (PMID: 12244299) Kuglstatter A. … Nagai K. (Nat. Struct. Biol. 2002) 3 4 22 65
  3. Crystal structure of an early protein-RNA assembly complex of the signal recognition particle. (PMID: 11641499) Wild K. … Cusack S. (Science 2001) 3 4 22 65
  4. Isolation and characterization of a cDNA clone encoding the 19 kDa protein of signal recognition particle (SRP): expression and binding to 7SL RNA. (PMID: 2460823) Lingelbach K. … Dobberstein B. (Nucleic Acids Res. 1988) 2 3 4 65
  5. A threefold RNA-protein interface in the signal recognition particle gates native complex assembly. (PMID: 17434535) Maity T.S. … Weeks K.M. (J. Mol. Biol. 2007) 3 22 65

Products for SRP19 Gene

Sources for SRP19 Gene

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