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SRP14 Gene

protein-coding   GIFtS: 59
GCID: GC15M040327

Signal Recognition Particle 14kDa (Homologous Alu RNA Binding...

(Previous name: signal recognition particle 14kD (homologous Alu RNA-binding...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Signal Recognition Particle 14kDa (Homologous Alu RNA Binding
Protein)1 2
18 KDa Alu RNA-Binding Protein2 3
Signal Recognition Particle 14kD (Homologous Alu RNA-Binding Protein)1
ALURBP2
Signal Recognition Particle 14 KDa Protein2

External Ids:    HGNC: 112991   Entrez Gene: 67272   Ensembl: ENSG000001403197   OMIM: 6007085   UniProtKB: P371083   

Export aliases for SRP14 gene to outside databases

Previous GC identifers: GC15M035695 GC15M033223 GC15M037907 GC15M038044 GC15M038115 GC15M017172


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SRP14 Gene:
SRP14 (signal recognition particle 14kDa (homologous Alu RNA binding protein)) is a protein-coding gene. GO annotations related to this gene include endoplasmic reticulum signal peptide binding and RNA binding.

UniProtKB/Swiss-Prot: SRP14_HUMAN, P37108
Function: Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough
endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the
elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the SRP14 gene promoter:
         C/EBPbeta   AML1a   Tal-1beta   HNF-1A   C/EBPalpha   AREB6   HNF-1   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSRP14 promoter sequence
   Search Chromatin IP Primers for SRP14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SRP14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22   Ensembl cytogenetic band:  15q15.1   HGNC cytogenetic band: 15q22

SRP14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRP14 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M040327:  view genomic region     (about GC identifiers)

Start:
40,327,891 bp from pter      End:
40,331,389 bp from pter
Size:
3,499 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SRP14_HUMAN, P37108 (See protein sequence)
Recommended Name: Signal recognition particle 14 kDa protein  
Size: 136 amino acids; 14570 Da
Subunit: Signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits:
SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9
3 PDB 3D structures from and Proteopedia for SRP14:
1E8O (3D)        1E8S (3D)        1RY1 (3D)    
Secondary accessions: B5BUF5 Q6B0K5 Q96Q14

Explore the universe of human proteins at neXtProt for SRP14: NX_P37108

Explore proteomics data for SRP14 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys43, Lys55, Lys74, Lys78
  • Modification sites at PhosphoSitePlus

  • See SRP14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003125.3  
    ENSEMBL proteins: 
     ENSP00000267884   ENSP00000453361   ENSP00000452756   ENSP00000453120  
    Reactome Protein details: P37108

    SRP14 Human Recombinant Protein Products:

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    Novus Biologicals SRP14 Proteins
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    ProSpec Recombinant Protein for SRP14
    Cloud-Clone Corp. Proteins for SRP14

     
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    antibodies-online proteins for SRP14 (13 products) 

     
    antibodies-online peptides for SRP14

    SRP14 Antibody Products:

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    SRP14 Assay Products:

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    Cloud-Clone Corp. ELISAs for SRP14
    Cloud-Clone Corp. CLIAs for SRP14
    Search eBioscience for ELISAs for SRP14 
    antibodies-online kits for SRP14 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR003210 Signal_recog_particle_SRP14
     IPR009018 Signal_recog_particle_SRP9/14

    Graphical View of Domain Structure for InterPro Entry P37108

    ProtoNet protein and cluster: P37108

    1 Blocks protein domain: IPB003210 Signal recognition particle

    UniProtKB/Swiss-Prot: SRP14_HUMAN, P37108
    Similarity: Belongs to the SRP14 family


    Find genes that share domains with SRP14           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRP14_HUMAN, P37108
    Function: Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough
    endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the
    elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding

         Genatlas biochemistry entry for SRP14:
    signal recognition particle (14kDa),binding the Alu homologous region of 7SL RNA,with five or more CAG repeats

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS2557625
    GO:00083127S RNA binding IEA--
    GO:0030942endoplasmic reticulum signal peptide binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with SRP14           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SRP14:
     Decreased viability of wild-ty  Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SRP14

    miRNA
    Products:
        
    miRTarBase miRNAs that target SRP14:
    hsa-mir-26b-5p (MIRT028782), hsa-mir-33b-5p (MIRT039579)

    Block miRNA regulation of human, mouse, rat SRP14 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate SRP14:
    hsa-miR-3926 hsa-miR-146a hsa-miR-3148 hsa-miR-146b-5p hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidSRP14 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SRP14
    Predesigned siRNA for gene silencing in human, mouse, rat SRP14

    Gene Editing
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    OriGene ORF clones in mouse, rat for SRP14
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    GenScript: all cDNA clones in your preferred vector: SRP14 (NM_003134)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRP14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRP14
    Addgene plasmids for SRP14 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SRP14 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRP14

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12213) for SRP14 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SRP14_HUMAN, P37108: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    endoplasmic reticulum2
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005786signal recognition particle, endoplasmic reticulum targeting IDA18089836
    GO:0005829cytosol TAS--
    GO:0045171intercellular bridge IDA--

    Find genes that share ontologies with SRP14           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SRP14 About    
    See pathways by source

    SuperPathContained pathways About
    1Influenza Viral RNA Transcription and Replication
    SRP-dependent cotranslational protein targeting to membrane0.83
    Translation0.82
    2Gene Expression
    Gene Expression0.40
    3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    4Protein export
    Protein export


    Find genes that share SuperPaths with SRP14           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SRP14
        SRP-dependent cotranslational protein targeting to membrane


    1 Kegg Pathway  (Kegg details for SRP14):
        Protein export

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SRP14
    Interactions:

        GeneGlobe Interaction Network for SRP14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SRP14 (P371082, 3 ENSP000002678844) via UniProtKB, MINT, STRING, and/or I2D (see all 118)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583I2D: score=1 
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    NSFL1CQ9UNZ23, ENSP000002168794I2D: score=3 STRING: ENSP00000216879
    SRP9P494583, ENSP000003052304I2D: score=3 STRING: ENSP00000305230
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation TAS--
    GO:0006613cotranslational protein targeting to membrane TAS2557625
    GO:0006614SRP-dependent cotranslational protein targeting to membrane TAS--
    GO:0010467gene expression TAS--
    GO:0042493response to drug IDA18089836

    Find genes that share ontologies with SRP14           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SRP14



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SRP14 gene: 
    NM_003134.4  

    Unigene Cluster for SRP14:

    Signal recognition particle 14kDa (homologous Alu RNA binding protein)
    Hs.533732  [show with all ESTs]
    Unigene Representative Sequence: BM805684
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000267884(uc001zkq.2 uc001zkr.2) ENST00000558527 ENST00000558720
    ENST00000560773 ENST00000559439 ENST00000559475 ENST00000559081 ENST00000558243

    miRNA
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    Block miRNA regulation of human, mouse, rat SRP14 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate SRP14:
    hsa-miR-3926 hsa-miR-146a hsa-miR-3148 hsa-miR-146b-5p hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidSRP14 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SRP14
    Predesigned siRNA for gene silencing in human, mouse, rat SRP14
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SRP14 (NM_003134)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRP14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRP14
    Addgene plasmids for SRP14 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SRP14
    OriGene qSTAR qPCR primer pairs in human, mouse for SRP14
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SRP14
      QuantiTect SYBR Green Assays in human, mouse, rat SRP14
      QuantiFast Probe-based Assays in human, mouse, rat SRP14
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12213) for SRP14 

    Additional mRNA sequence: 

    AB061546.1 AB451391.1 BC035495.2 BC051006.1 BC071716.1 BC100031.1 U07857.1 U92988.1 
    X73459.1 

    Selected DOTS entries (see all 33):

    DT.100851985  DT.450284  DT.91836194  DT.97848108  DT.95369701  DT.100672301  DT.95369711  DT.95369700 
    DT.91782842  DT.91782858  DT.100672305  DT.120713908  DT.95369712  DT.97848091  DT.40106177  DT.95369704 
    DT.120713912  DT.100059661  DT.95202093  DT.95369708  DT.95369710  DT.100672298  DT.121073714  DT.95369703 

    Selected AceView cDNA sequences (see all 788):

    BX437455 AI468088 CA946542 BP342589 BQ070502 AV652005 AV651568 AA151580 
    AW062960 AV651950 BC035495 AI363142 CR610559 N69859 AI193745 AV651585 
    CR610388 BM761915 AI174841 CR614758 N27151 BU616352 AA191611 BP341450 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SRP14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGTTTATC
    SRP14 Expression
    About this image

    SRP14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SRP14 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.533732
        Custom PCR Arrays for SRP14
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRP14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SRP14 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srp141 , 5 signal recognition particle 141, 5 87.46(n)1
    92.08(a)1
      2 (59.40 cM)5
    208131  NM_009273.41  NP_033299.11 
     1184758505 
    chicken
    (Gallus gallus)
    Aves SRP141 signal recognition particle 14kDa (homologous Alu RNA binding protein) less 81.19(n)
    93.07(a)
      423284  NM_001006478.2  NP_001006478.1 
    lizard
    (Anolis carolinensis)
    Reptilia SRP146
    signal recognition particle 14kDa (homologous Alu ...
    90(a)
    1 ↔ 1
    GL343264.1(1711729-1718960)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.330432 Xenopus laevis transcribed sequence with moderate similarity to protein pirA56062 (H.sapiens) A56062 Alu RNA-binding protein - human less 77.01(n)    CA973145.1 
    zebrafish
    (Danio rerio)
    Actinopterygii srp141 signal recognition particle 14 72.28(n)
    83.17(a)
      619260  NM_001033741.1  NP_001028913.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Srp146
    Signal recognition particle protein 14
    38(a)
    1 ↔ 1
    3R(16405846-16406486)
    worm
    (Caenorhabditis elegans)
    Secernentea F25G6.86
    Protein F25G6.8 (F25G6.8) mRNA, complete cds
    41(a)
    1 ↔ 1
    V(8564303-8565175) WBGene00017799


    ENSEMBL Gene Tree for SRP14 (if available)
    TreeFam Gene Tree for SRP14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SRP14 gene

    Find genes that share paralogs with SRP14           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for SRP14 (see all 6)
    PGOHUM00000242861 PGOHUM00000239631 PGOHUM00000250840 PGOHUM00000244331 PGOHUM00000237844


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SRP14 (see all 53)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs559893171,2
    C--40327796(+) CTGCT-/GCTTTTTA 1 -- ds50011Minor allele frequency- GCT:0.00NA 2
    rs1509643191,2
    --40328413(+) TTCCAA/CAAGGA 1 -- ut310--------
    rs1130516371,2
    C,F--40328451(+) GTGGGG/CGAACC 1 -- ut311Minor allele frequency- C:0.50WA 2
    rs2004151101,2
    C--40328501(+) TCAGTC/GGTTAA 1 -- ut310--------
    rs1497321771,2
    C--40328517(+) GAAAGC/TAGGAA 1 -- ut310--------
    rs86831,2
    H--40328551(-) cagcaG/Acaaca 2 /T /A mis1 ese34Minor allele frequency- A:0.00NS EA 404
    rs48141,2,,4
    C,F,H--40328557(-) CAACAG/ACAGCA 2 /T /A mis1 ese35Minor allele frequency- A:0.44MN NS NA 500
    rs169245191,2
    C--40328560(+) TGTTGC/TTGCTG 2 T A mis10--------
    rs75351,2,,4
    C,F,A,H--40328575(-) CAGCAG/CCAACA 2 /P /A mis121Minor allele frequency- C:0.26MN EA NS NA WA CSA 2579
    rs1998515891,2
    --40328590(+) TGCTGC/TGGCAG 2 T A mis10--------

    HapMap Linkage Disequilibrium report for SRP14 (40327891 - 40331389 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SRP14:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749592CNV Deletion23290073
    esv2749594CNV Deletion23290073
    esv2749593CNV Deletion23290073
    esv2749595CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SRP14
    DNA2.0 Custom Variant and Variant Library Synthesis for SRP14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600708    OMIM disorders: --


    Find genes that share disorders with SRP14           About GenesLikeMe

    Genetic Association Database (GAD): SRP14

    Export disorders for SRP14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SRP14 gene, integrated from 10 sources (see all 56):
    (articles sorted by number of sources associating them with SRP14)
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    1. A human Alu RNA-binding protein whose expression is associated with accumulation of small cytoplasmic Alu RNA. (PubMed id 8196634)1, 2, 3 Chang D.-Y....Maraia R.J. (Mol. Cell. Biol. 1994)
    2. Structure and assembly of the Alu domain of the mammalian signal recognition particle. (PubMed id 11089964)1, 2, 9 Weichenrieder O.... Cusack S. (Nature 2000)
    3. Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma. (PubMed id 22327514)1, 4 Postel-Vinay S....Delattre O. (Nat. Genet. 2012)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The SRP9/14 subunit of the signal recognition particle (SRP) is present in more than 20-fold excess over SRP in primate cells and exists primarily free but also in complex with small cytoplasmic Alu RNAs. (PubMed id 7542942)1, 2 Bovia F.... Strub K. (Mol. Biol. Cell 1995)
    6. Assembly of the Alu domain of the signal recognition particle (SRP): dimerization of the two protein components is required for efficient binding to SRP RNA. (PubMed id 2153922)1, 9 Strub K. and Walter P. (Mol. Cell. Biol. 1990)
    7. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)
    8. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    9. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1 Cloutier P.... Coulombe B. (PLoS Genet. 2013)
    10. Cleavage and polyadenylation specificity factor 1 (CPSF1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6. (PubMed id 23151878)1 Evsyukova I....Garcia-Blanco M.A. (RNA 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6727 HGNC: 11299 AceView: SRP14 Ensembl:ENSG00000140319 euGenes: HUgn6727
    ECgene: SRP14 Kegg: 6727 H-InvDB: SRP14

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SRP14 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Signal_recognition_particle

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SRP14 gene:
    Search GeneIP for patents involving SRP14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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