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Aliases for SRP14 Gene

Aliases for SRP14 Gene

  • Signal Recognition Particle 14kDa (Homologous Alu RNA Binding Protein) 2 3
  • 18 KDa Alu RNA-Binding Protein 3 4
  • Signal Recognition Particle 14kD (Homologous Alu RNA-Binding Protein) 2
  • Signal Recognition Particle 14 KDa Protein 3
  • ALURBP 3

External Ids for SRP14 Gene

Previous GeneCards Identifiers for SRP14 Gene

  • GC15M035695
  • GC15M033223
  • GC15M037907
  • GC15M038044
  • GC15M038115
  • GC15M040327
  • GC15M017172

Summaries for SRP14 Gene

GeneCards Summary for SRP14 Gene

SRP14 (Signal Recognition Particle 14kDa (Homologous Alu RNA Binding Protein)) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Gene Expression. GO annotations related to this gene include RNA binding and endoplasmic reticulum signal peptide binding.

UniProtKB/Swiss-Prot for SRP14 Gene

  • Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRP14 Gene

Genomics for SRP14 Gene

Regulatory Elements for SRP14 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SRP14 Gene

Start:
40,035,690 bp from pter
End:
40,039,188 bp from pter
Size:
3,499 bases
Orientation:
Minus strand

Genomic View for SRP14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SRP14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRP14 Gene

Proteins for SRP14 Gene

  • Protein details for SRP14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P37108-SRP14_HUMAN
    Recommended name:
    Signal recognition particle 14 kDa protein
    Protein Accession:
    P37108
    Secondary Accessions:
    • B5BUF5
    • Q6B0K5
    • Q96Q14

    Protein attributes for SRP14 Gene

    Size:
    136 amino acids
    Molecular mass:
    14570 Da
    Quaternary structure:
    • Signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.

    Three dimensional structures from OCA and Proteopedia for SRP14 Gene

neXtProt entry for SRP14 Gene

Proteomics data for SRP14 Gene at MOPED

Post-translational modifications for SRP14 Gene

  • Ubiquitination at Lys43, Lys55, Lys74, and Lys78
  • Modification sites at PhosphoSitePlus

Other Protein References for SRP14 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SRP14 Gene

Domains for SRP14 Gene

Suggested Antigen Peptide Sequences for SRP14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P37108

UniProtKB/Swiss-Prot:

SRP14_HUMAN :
  • P37108
Family:
  • Belongs to the SRP14 family.
genes like me logo Genes that share domains with SRP14: view

No data available for Gene Families for SRP14 Gene

Function for SRP14 Gene

Molecular function for SRP14 Gene

GENATLAS Biochemistry: signal recognition particle (14kDa),binding the Alu homologous region of 7SL RNA,with five or more CAG repeats
UniProtKB/Swiss-Prot Function: Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding

Gene Ontology (GO) - Molecular Function for SRP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 2557625
GO:0005515 protein binding IPI 22720776
GO:0008312 7S RNA binding IEA --
GO:0030942 endoplasmic reticulum signal peptide binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SRP14: view

Phenotypes for SRP14 Gene

genes like me logo Genes that share phenotypes with SRP14: view

Animal Model Products

CRISPR Products

miRNA for SRP14 Gene

miRTarBase miRNAs that target SRP14

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SRP14

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SRP14 Gene

Localization for SRP14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRP14 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRP14 Gene COMPARTMENTS Subcellular localization image for SRP14 gene
Compartment Confidence
cytosol 4
endoplasmic reticulum 2
nucleus 2

Gene Ontology (GO) - Cellular Components for SRP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22720776
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005786 signal recognition particle, endoplasmic reticulum targeting IDA 18089836
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SRP14: view

Pathways for SRP14 Gene

genes like me logo Genes that share pathways with SRP14: view

Pathways by source for SRP14 Gene

Gene Ontology (GO) - Biological Process for SRP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation TAS --
GO:0006613 cotranslational protein targeting to membrane TAS 2557625
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
GO:0010467 gene expression TAS --
GO:0042493 response to drug IDA 18089836
genes like me logo Genes that share ontologies with SRP14: view

Transcripts for SRP14 Gene

Unigene Clusters for SRP14 Gene

Signal recognition particle 14kDa (homologous Alu RNA binding protein):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SRP14

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRP14 Gene

No ASD Table

Relevant External Links for SRP14 Gene

GeneLoc Exon Structure for
SRP14
ECgene alternative splicing isoforms for
SRP14

Expression for SRP14 Gene

mRNA expression in normal human tissues for SRP14 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SRP14 Gene

SOURCE GeneReport for Unigene cluster for SRP14 Gene Hs.533732

genes like me logo Genes that share expressions with SRP14: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SRP14 Gene

Orthologs for SRP14 Gene

This gene was present in the common ancestor of animals.

Orthologs for SRP14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRP14 35
  • 99.51 (n)
  • 99.26 (a)
SRP14 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SRP14 35
  • 90.43 (n)
  • 94.68 (a)
SRP14 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 89 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
SRP14 35
  • 89.72 (n)
  • 94.68 (a)
SRP14 36
  • 92 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Srp14 35
  • 87.46 (n)
  • 92.08 (a)
Srp14 16
Srp14 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SRP14 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRP14 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Srp14 35
  • 87.79 (n)
  • 92.08 (a)
chicken
(Gallus gallus)
Aves SRP14 35
  • 81.19 (n)
  • 93.07 (a)
SRP14 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRP14 36
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.33043 35
tropical clawed frog
(Silurana tropicalis)
Amphibia srp14 35
  • 74.59 (n)
  • 90.1 (a)
Str.6625 35
zebrafish
(Danio rerio)
Actinopterygii srp14 35
  • 72.28 (n)
  • 83.17 (a)
srp14 36
  • 82 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Srp14 36
  • 38 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F25G6.8 36
  • 41 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1955 35
Species with no ortholog for SRP14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRP14 Gene

ENSEMBL:
Gene Tree for SRP14 (if available)
TreeFam:
Gene Tree for SRP14 (if available)

Paralogs for SRP14 Gene

genes like me logo Genes that share paralogs with SRP14: view

No data available for Paralogs for SRP14 Gene

Variants for SRP14 Gene

Sequence variations from dbSNP and Humsavar for SRP14 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs4814 - 40,036,356(-) CAACA(A/G)CAGCA reference, missense, nc-transcript-variant
rs7535 - 40,036,374(-) CAGCA(C/G)CAACA reference, missense, nc-transcript-variant
rs8208 -- 40,036,464(-) ATGGG(C/T)TGAAG reference, synonymous-codon, nc-transcript-variant
rs8683 -- 40,036,350(-) cagca(A/G)caaca missense, reference, nc-transcript-variant
rs8874 -- 40,036,370(-) CAGCA(A/G)CAACA reference, frameshift-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for SRP14 Gene

Variant ID Type Subtype PubMed ID
esv2749592 CNV Deletion 23290073
esv2749593 CNV Deletion 23290073
esv2749594 CNV Deletion 23290073
esv2749595 CNV Deletion 23290073

Relevant External Links for SRP14 Gene

HapMap Linkage Disequilibrium report
SRP14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRP14 Gene

Disorders for SRP14 Gene

Relevant External Links for SRP14

Genetic Association Database (GAD)
SRP14
genes like me logo Genes that share disorders with SRP14: view

No data available for UniProtKB/Swiss-Prot for SRP14 Gene

Publications for SRP14 Gene

  1. Structure and assembly of the Alu domain of the mammalian signal recognition particle. (PMID: 11089964) Weichenrieder O. … Cusack S. (Nature 2000) 3 4 23
  2. A human Alu RNA-binding protein whose expression is associated with accumulation of small cytoplasmic Alu RNA. (PMID: 8196634) Chang D.-Y. … Maraia R.J. (Mol. Cell. Biol. 1994) 2 3 4
  3. Assembly of the Alu domain of the signal recognition particle (SRP): dimerization of the two protein components is required for efficient binding to SRP RNA. (PMID: 2153922) Strub K. … Walter P. (Mol. Cell. Biol. 1990) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma. (PMID: 22327514) Postel-Vinay S. … Delattre O. (Nat. Genet. 2012) 3 48

Products for SRP14 Gene

  • Addgene plasmids for SRP14

Sources for SRP14 Gene

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