Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SRP14 Gene

Aliases for SRP14 Gene

  • Signal Recognition Particle 14 2 3 5
  • Homologous Alu RNA Binding Protein 2 3
  • 18 KDa Alu RNA-Binding Protein 3 4
  • Signal Recognition Particle 14kD (Homologous Alu RNA-Binding Protein) 2
  • Signal Recognition Particle 14 KDa Protein 3
  • ALURBP 3

External Ids for SRP14 Gene

Previous GeneCards Identifiers for SRP14 Gene

  • GC15M035695
  • GC15M033223
  • GC15M037907
  • GC15M038044
  • GC15M038115
  • GC15M040327
  • GC15M017172

Summaries for SRP14 Gene

GeneCards Summary for SRP14 Gene

SRP14 (Signal Recognition Particle 14) is a Protein Coding gene. Among its related pathways are Immune System and Viral mRNA Translation. GO annotations related to this gene include poly(A) RNA binding and 7S RNA binding.

UniProtKB/Swiss-Prot for SRP14 Gene

  • Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRP14 Gene

Genomics for SRP14 Gene

Regulatory Elements for SRP14 Gene

Enhancers for SRP14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F040090 2.2 VISTA FANTOM5 ENCODE 21.9 -61.2 -61171 18.8 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ENSG00000259211 DNAJC17 BMF CHST14 RPLP0P10 BAHD1 SRP14 EIF2AK4 SRP14-AS1 ENSG00000259432
GH15F040080 1.7 FANTOM5 Ensembl ENCODE 24.3 -43.1 -43084 3.9 PKNOX1 ATF1 MLX ARID4B DMAP1 ZNF48 GATA2 SP5 NFYC MXD4 SRP14 SRP14-AS1 BMF EIF2AK4 ANKRD63 BUB1B PAK6 C15orf56 PLCB2 RPLP0P10
GH15F040068 1.3 Ensembl ENCODE 25.6 -30.1 -30121 2.6 HDGF PKNOX1 FEZF1 GLI4 ZNF48 BRCA1 ZNF2 YY1 GLIS2 ZNF207 SRP14 SRP14-AS1 EIF2AK4 BMF PAK6 C15orf56 PLCB2 RPLP0P10 LOC102724328 GC15M040064
GH15F040074 1.3 Ensembl ENCODE 25 -36.2 -36212 1.2 CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 KLF13 ZNF263 NFYC SRP14 SRP14-AS1 ENSG00000259211 BAHD1 BUB1B BMF DNAJC17 RAD51-AS1 PAK6 C15orf56
GH15F040062 1.2 Ensembl ENCODE 26.3 -25.2 -25171 3.0 HDGF ARID4B ZNF48 FOS NFYC MXD4 JUNB REST MIER2 TBX21 SRP14 EIF2AK4 SRP14-AS1 BMF BUB1B RPLP0P10 PLCB2 PAK6 C15orf56 GC15M040064
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SRP14 on UCSC Golden Path with GeneCards custom track

Promoters for SRP14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000406536 188 2801 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 CBX5

Genomic Location for SRP14 Gene

Chromosome:
15
Start:
40,035,690 bp from pter
End:
40,039,188 bp from pter
Size:
3,499 bases
Orientation:
Minus strand

Genomic View for SRP14 Gene

Genes around SRP14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRP14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRP14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRP14 Gene

Proteins for SRP14 Gene

  • Protein details for SRP14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P37108-SRP14_HUMAN
    Recommended name:
    Signal recognition particle 14 kDa protein
    Protein Accession:
    P37108
    Secondary Accessions:
    • B5BUF5
    • Q6B0K5
    • Q96Q14

    Protein attributes for SRP14 Gene

    Size:
    136 amino acids
    Molecular mass:
    14570 Da
    Quaternary structure:
    • Signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.

    Three dimensional structures from OCA and Proteopedia for SRP14 Gene

neXtProt entry for SRP14 Gene

Post-translational modifications for SRP14 Gene

  • Ubiquitination at Lys 43, Lys 55, Lys 74, and Lys 78
  • Modification sites at PhosphoSitePlus

Other Protein References for SRP14 Gene

No data available for DME Specific Peptides for SRP14 Gene

Domains & Families for SRP14 Gene

Suggested Antigen Peptide Sequences for SRP14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P37108

UniProtKB/Swiss-Prot:

SRP14_HUMAN :
  • Belongs to the SRP14 family.
Family:
  • Belongs to the SRP14 family.
genes like me logo Genes that share domains with SRP14: view

No data available for Gene Families for SRP14 Gene

Function for SRP14 Gene

Molecular function for SRP14 Gene

GENATLAS Biochemistry:
signal recognition particle (14kDa),binding the Alu homologous region of 7SL RNA,with five or more CAG repeats
UniProtKB/Swiss-Prot Function:
Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.

Gene Ontology (GO) - Molecular Function for SRP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 2557625
GO:0005515 protein binding IPI 22720776
GO:0008312 7S RNA binding IEA --
GO:0030942 endoplasmic reticulum signal peptide binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SRP14: view
genes like me logo Genes that share phenotypes with SRP14: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SRP14

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SRP14 Gene

Localization for SRP14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRP14 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRP14 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
endoplasmic reticulum 2

Gene Ontology (GO) - Cellular Components for SRP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22720776
GO:0005737 cytoplasm TAS 8196634
GO:0005786 signal recognition particle, endoplasmic reticulum targeting IEA,IDA 18089836
GO:0005829 cytosol TAS --
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with SRP14: view

Pathways & Interactions for SRP14 Gene

genes like me logo Genes that share pathways with SRP14: view

Pathways by source for SRP14 Gene

Gene Ontology (GO) - Biological Process for SRP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006613 cotranslational protein targeting to membrane TAS 2557625
GO:0006614 SRP-dependent cotranslational protein targeting to membrane IEA,TAS --
GO:0042493 response to drug IDA 18089836
GO:0045047 protein targeting to ER IMP 18089836
genes like me logo Genes that share ontologies with SRP14: view

No data available for SIGNOR curated interactions for SRP14 Gene

Transcripts for SRP14 Gene

Unigene Clusters for SRP14 Gene

Signal recognition particle 14kDa (homologous Alu RNA binding protein):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SRP14

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRP14 Gene

No ASD Table

Relevant External Links for SRP14 Gene

GeneLoc Exon Structure for
SRP14
ECgene alternative splicing isoforms for
SRP14

Expression for SRP14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SRP14 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SRP14 Gene



Protein tissue co-expression partners for SRP14 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SRP14 Gene:

SRP14

SOURCE GeneReport for Unigene cluster for SRP14 Gene:

Hs.533732
genes like me logo Genes that share expression patterns with SRP14: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SRP14 Gene

Orthologs for SRP14 Gene

This gene was present in the common ancestor of animals.

Orthologs for SRP14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRP14 34 35
  • 99.51 (n)
cow
(Bos Taurus)
Mammalia SRP14 34 35
  • 90.43 (n)
oppossum
(Monodelphis domestica)
Mammalia SRP14 35
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRP14 34 35
  • 89.72 (n)
-- 35
  • 89 (a)
OneToMany
-- 35
  • 86 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Srp14 34
  • 87.79 (n)
mouse
(Mus musculus)
Mammalia Srp14 34 16 35
  • 87.46 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SRP14 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves SRP14 34 35
  • 81.19 (n)
lizard
(Anolis carolinensis)
Reptilia SRP14 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia srp14 34
  • 74.59 (n)
Str.6625 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.33043 34
zebrafish
(Danio rerio)
Actinopterygii srp14 34 35
  • 72.28 (n)
fruit fly
(Drosophila melanogaster)
Insecta Srp14 35
  • 38 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F25G6.8 35
  • 41 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1955 34
Species where no ortholog for SRP14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRP14 Gene

ENSEMBL:
Gene Tree for SRP14 (if available)
TreeFam:
Gene Tree for SRP14 (if available)

Paralogs for SRP14 Gene

genes like me logo Genes that share paralogs with SRP14: view

No data available for Paralogs for SRP14 Gene

Variants for SRP14 Gene

Sequence variations from dbSNP and Humsavar for SRP14 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1047574 -- 40,035,489(+) AAAAA(A/T)TTTTT downstream-variant-500B, utr-variant-3-prime
rs1059395 -- 40,038,317(-) TGTTA(A/C)GAGCT upstream-variant-2KB, reference, synonymous-codon, utr-variant-5-prime
rs1059613 -- 40,036,246(-) CCCCC(A/C)CAGTA utr-variant-3-prime
rs111344789 -- 40,037,616(+) TTGTC(C/G)TTAGG intron-variant, upstream-variant-2KB
rs112168341 -- 40,038,728(+) TCCCT(A/G)CTATT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SRP14 Gene

Variant ID Type Subtype PubMed ID
dgv1193n106 CNV deletion 24896259
esv2749592 CNV deletion 23290073
esv2749593 CNV deletion 23290073
esv2749594 CNV deletion 23290073
esv2749595 CNV deletion 23290073
nsv958007 CNV deletion 24416366
nsv974561 CNV duplication 23825009

Variation tolerance for SRP14 Gene

Residual Variation Intolerance Score: 52.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.49; 10.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRP14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRP14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRP14 Gene

Disorders for SRP14 Gene

Relevant External Links for SRP14

Genetic Association Database (GAD)
SRP14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRP14

No disorders were found for SRP14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRP14 Gene

Publications for SRP14 Gene

  1. Structure and assembly of the Alu domain of the mammalian signal recognition particle. (PMID: 11089964) Weichenrieder O. … Cusack S. (Nature 2000) 3 4 22 64
  2. A human Alu RNA-binding protein whose expression is associated with accumulation of small cytoplasmic Alu RNA. (PMID: 8196634) Chang D.-Y. … Maraia R.J. (Mol. Cell. Biol. 1994) 2 3 4 64
  3. Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma. (PMID: 22327514) Postel-Vinay S. … Delattre O. (Nat. Genet. 2012) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The SRP9/14 subunit of the signal recognition particle (SRP) is present in more than 20-fold excess over SRP in primate cells and exists primarily free but also in complex with small cytoplasmic Alu RNAs. (PMID: 7542942) Bovia F. … Strub K. (Mol. Biol. Cell 1995) 3 4 64

Products for SRP14 Gene

Sources for SRP14 Gene

Content
Loading form....