Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SRP14 Gene

protein-coding   GIFtS: 58
GCID: GC15M040327

Signal Recognition Particle 14kDa (Homologous Alu RNA Binding...

(Previous name: signal recognition particle 14kD (homologous Alu RNA-binding...)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Signal Recognition Particle 14kDa (Homologous Alu RNA Binding
Protein)1 2
18 KDa Alu RNA-Binding Protein2 3
Signal Recognition Particle 14kD (Homologous Alu RNA-Binding Protein)1
ALURBP2
Signal Recognition Particle 14 KDa Protein2

External Ids:    HGNC: 112991   Entrez Gene: 67272   Ensembl: ENSG000001403197   OMIM: 6007085   UniProtKB: P371083   

Export aliases for SRP14 gene to outside databases

Previous GC identifers: GC15M035695 GC15M033223 GC15M037907 GC15M038044 GC15M038115 GC15M017172


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SRP14 Gene: 
SRP14 (signal recognition particle 14kDa (homologous Alu RNA binding protein)) is a protein-coding gene. Diseases associated with SRP14 include sarcoma, and among its related super-pathways are Viral mRNA Translation and Generic Transcription Pathway. GO annotations related to this gene include endoplasmic reticulum signal peptide binding and RNA binding.

UniProtKB/Swiss-Prot: SRP14_HUMAN, P37108
Function: Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough
endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the
elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.2  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SRP14 gene promoter:
         C/EBPbeta   AML1a   Tal-1beta   HNF-1A   C/EBPalpha   AREB6   HNF-1   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSRP14 promoter sequence
   Search SABiosciences Chromatin IP Primers for SRP14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRP14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22   Ensembl cytogenetic band:  15q15.1   HGNC cytogenetic band: 15q22

SRP14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRP14 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M040327:  view genomic region     (about GC identifiers)

Start:
40,327,891 bp from pter      End:
40,331,389 bp from pter
Size:
3,499 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SRP14_HUMAN, P37108 (See protein sequence)
Recommended Name: Signal recognition particle 14 kDa protein  
Size: 136 amino acids; 14570 Da
Subunit: Signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits:
SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9
Subcellular location: Cytoplasm
3 PDB 3D structures from and Proteopedia for SRP14:
1E8O (3D)        1E8S (3D)        1RY1 (3D)    
Secondary accessions: B5BUF5 Q6B0K5 Q96Q14

Explore the universe of human proteins at neXtProt for SRP14: NX_P37108

Explore proteomics data for SRP14 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P37108

  • SRP14 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SRP14 Protein Expression
    REFSEQ proteins: NP_003125.3  
    ENSEMBL proteins: 
     ENSP00000267884   ENSP00000453361   ENSP00000452756   ENSP00000453120  
    Reactome Protein details: P37108
    Human Recombinant Protein Products for SRP14: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SRP14
    OriGene Protein Over-expression Lysate for SRP14
    OriGene MassSpec for SRP14 
    OriGene Custom Protein Services for SRP14
    GenScript Custom Purified and Recombinant Proteins Services for SRP14
    Novus Biologicals SRP14 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for SRP14
    Cloud-Clone Corp. Proteins for SRP14 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS8196634
    GO:0005786signal recognition particle, endoplasmic reticulum targeting IDA18089836
    GO:0005829cytosol TAS--
    GO:0048500signal recognition particle ----

    SRP14 for ontologies           About GeneDecksing



    SRP14 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SRP14
    GenScript Custom Superior Antibodies Services for SRP14
    Novus Biologicals SRP14 Antibodies
    Abcam antibodies for SRP14
    Cloud-Clone Corp. Antibodies for SRP14 
    ThermoFisher Antibodies for SRP14
    LSBio Antibodies in human, mouse, rat for SRP14 

    Assay Products for SRP14: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SRP14
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SRP14
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SRP14 
    Cloud-Clone Corp. CLIAs for SRP14


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR003210 Signal_recog_particle_SRP14
     IPR009018 Signal_recog_particle_SRP9/14

    Graphical View of Domain Structure for InterPro Entry P37108

    ProtoNet protein and cluster: P37108

    1 Blocks protein domain: IPB003210 Signal recognition particle

    UniProtKB/Swiss-Prot: SRP14_HUMAN, P37108
    Similarity: Belongs to the SRP14 family


    SRP14 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRP14_HUMAN, P37108
    Function: Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough
    endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the
    elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding

         Genatlas biochemistry entry for SRP14:
    signal recognition particle (14kDa),binding the Alu homologous region of 7SL RNA,with five or more CAG repeats

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS2557625
    GO:00083127S RNA binding IEA--
    GO:0030942endoplasmic reticulum signal peptide binding IEA--
         
    SRP14 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SRP14:
     Decreased viability of wild-ty  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SRP14 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SRP14

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SRP14 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SRP14 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SRP14
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate SRP14:
    hsa-miR-3926 hsa-miR-146a hsa-miR-3148 hsa-miR-146b-5p hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidSRP14 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SRP14
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRP14

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SRP14
    Sirion Biotech Customized adenovirus for overexpression of SRP14

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SRP14 (see all 7)
    OriGene ORF clones in mouse, rat for SRP14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SRP14 (NM_003134)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRP14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRP14
    Sirion Biotech Customized lentivirus for stable overexpression of SRP14 
                         Customized lentivirus expression plasmids for stable overexpression of SRP14 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SRP14
    Search LifeMap BioReagents cell lines for SRP14
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRP14


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SRP14 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Viral mRNA Translation
    Translation0.78
    SRP-dependent cotranslational protein targeting to membrane0.77
    2Generic Transcription Pathway
    Gene Expression0.47
    3Asparagine N-linked glycosylation
    Metabolism of proteins0.35
    4Protein export
    Protein export

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for SRP14
        Translation
    SRP-dependent cotranslational protein targeting to membrane
    Metabolism of proteins
    Gene Expression


    1         Kegg Pathway  (Kegg details for SRP14):
        Protein export


    SRP14 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SRP14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/111 Interacting proteins for SRP14 (P371082, 3 ENSP000002678844) via UniProtKB, MINT, STRING, and/or I2D (see all 111)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583I2D: score=1 
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    NSFL1CQ9UNZ23, ENSP000002168794I2D: score=3 STRING: ENSP00000216879
    SRP9P494583, ENSP000003052304I2D: score=3 STRING: ENSP00000305230
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation TAS--
    GO:0006613cotranslational protein targeting to membrane TAS2557625
    GO:0006614SRP-dependent cotranslational protein targeting to membrane TAS--
    GO:0010467gene expression TAS--
    GO:0042493response to drug IDA18089836

    SRP14 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SRP14

    Search CenterWatch for drugs/clinical trials and news about SRP14

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SRP14 gene: 
    NM_003134.4  

    Unigene Cluster for SRP14:

    Signal recognition particle 14kDa (homologous Alu RNA binding protein)
    Hs.533732  [show with all ESTs]
    Unigene Representative Sequence: BM805684
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000267884(uc001zkq.2 uc001zkr.2) ENST00000558527 ENST00000558720
    ENST00000560773 ENST00000559439 ENST00000559475 ENST00000559081 ENST00000558243

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SRP14
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate SRP14:
    hsa-miR-3926 hsa-miR-146a hsa-miR-3148 hsa-miR-146b-5p hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidSRP14 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SRP14
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRP14
    Clone
    Products:
         
    OriGene clones in human, mouse for SRP14 (see all 7)
    OriGene ORF clones in mouse, rat for SRP14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SRP14 (NM_003134)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRP14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRP14
    Sirion Biotech Customized lentivirus for stable overexpression of SRP14 
                         Customized lentivirus expression plasmids for stable overexpression of SRP14 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SRP14
    OriGene qSTAR qPCR primer pairs in human, mouse for SRP14
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SRP14
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRP14
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRP14

    Additional mRNA sequence: 

    AB061546.1 AB451391.1 BC035495.2 BC051006.1 BC071716.1 BC100031.1 U07857.1 U92988.1 
    X73459.1 

    24/33 DOTS entries (see all 33):

    DT.100851985  DT.450284  DT.91836194  DT.97848108  DT.95369701  DT.100672301  DT.95369711  DT.95369700 
    DT.91782842  DT.91782858  DT.100672305  DT.120713908  DT.95369712  DT.97848091  DT.40106177  DT.95369704 
    DT.120713912  DT.100059661  DT.95202093  DT.95369708  DT.95369710  DT.100672298  DT.121073714  DT.95369703 

    24/788 AceView cDNA sequences (see all 788):

    BC035495 BX437455 AV651950 BQ070502 AI110696 AA151580 AW062960 AV651608 
    BF823050 AI088575 CR610388 BM761915 AI174841 CR614758 N27151 CA946542 
    AI468088 AV652005 BM845137 AI061625 BF115384 BU727789 CR596116 CA428143 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SRP14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGTTTATC
    SRP14 Expression
    About this image


    See SRP14 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SRP14

    SOURCE GeneReport for Unigene cluster: Hs.533732
        SABiosciences Custom PCR Arrays for SRP14
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SRP14
    OriGene qSTAR qPCR primer pairs in human, mouse for SRP14
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SRP14
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRP14
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRP14
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRP14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SRP14 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srp141 , 5 signal recognition particle 141, 5 87.16(n)1
    89.91(a)1
      2 (59.40 cM)5
    208131  NM_009273.41  NP_033299.11 
     1184758505 
    chicken
    (Gallus gallus)
    Aves SRP141 signal recognition particle 14kDa (homologous Alu RNA more 81.17(n)
    91.67(a)
      423284  NM_001006478.1  NP_001006478.1 
    lizard
    (Anolis carolinensis)
    Reptilia SRP146
    Uncharacterized protein
    91(a)
    1 ↔ 1
    GL343264.1(1711729-1718960)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.330432 Xenopus laevis transcribed sequence with moderate similarity more 77.01(n)    CA973145.1 
    zebrafish
    (Danio rerio)
    Actinopterygii srp141 signal recognition particle 14 72.53(n)
    83.33(a)
      619260  NM_001033741.1  NP_001028913.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Srp146
    Signal recognition particle protein 14
    38(a)
    1 ↔ 1
    3R(16405846-16406486)
    worm
    (Caenorhabditis elegans)
    Secernentea F25G6.86
    Signal recognition particle 14 kDa protein
    41(a)
    1 ↔ 1
    V(8564303-8565177)


    ENSEMBL Gene Tree for SRP14 (if available)
    TreeFam Gene Tree for SRP14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SRP14 gene

    SRP14 for paralogs           About GeneDecksing


    5/6 Pseudogenes.org Pseudogenes for SRP14 (see all 6)
    PGOHUM00000242861 PGOHUM00000239631 PGOHUM00000250840 PGOHUM00000244331 PGOHUM00000237844


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/53 SNPs in SRP14 are shown (see all 53)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0280584
    ----see VAR_0280582 S I mis40--------
    VAR_0280574
    ----see VAR_0280572 P S mis40--------
    VAR_0280604
    ----see VAR_0280602 T A mis40--------
    rs559893171,2
    C--40327796(+) CTGCT-/GCTTTTTA 1 -- ds50011Minor allele frequency- GCT:0.00NA 2
    rs1509643191,2
    --40328413(+) TTCCAA/CAAGGA 1 -- ut310--------
    rs1130516371,2
    C,F--40328451(+) GTGGGG/CGAACC 1 -- ut311Minor allele frequency- C:0.50WA 2
    rs2004151101,2
    C--40328501(+) TCAGTC/GGTTAA 1 -- ut310--------
    rs1497321771,2
    C--40328517(+) GAAAGC/TAGGAA 1 -- ut310--------
    rs86831,2
    H--40328551(-) cagcaG/Acaaca 2 /T /A mis1 ese34Minor allele frequency- A:0.00NS EA 404
    rs48141,2,4
    C,F,H--40328557(-) CAACAG/ACAGCA 2 /T /A mis1 ese35Minor allele frequency- A:0.44MN NS NA 500

    HapMap Linkage Disequilibrium report for SRP14 (40327891 - 40331389 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SRP14:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2749592CNV Deletion23290073
    esv2749594CNV Deletion23290073
    esv2749593CNV Deletion23290073
    esv2749595CNV Deletion23290073

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SRP14
    DNA2.0 Custom Variant and Variant Library Synthesis for SRP14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600708    OMIM disorders: --

    2 diseases for SRP14:    About MalaCards
    sarcoma    


    SRP14 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SRP14

    Export disorders for SRP14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SRP14 gene, integrated from 9 sources (see all 55):
    (articles sorted by number of sources associating them with SRP14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human Alu RNA-binding protein whose expression is associated with accumulation of small cytoplasmic Alu RNA. (PubMed id 8196634)1, 2, 3 Chang D.-Y....Maraia R.J. (1994)
    2. Structure and assembly of the Alu domain of the mammalian signal recognition particle. (PubMed id 11089964)1, 2, 9 Weichenrieder O....Cusack S. (2000)
    3. Common variants near TARDBP and EGR2 are associated wi th susceptibility to Ewing sarcoma. (PubMed id 22327514)1, 4 Postel-Vinay S....Delattre O. (2012)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The SRP9/14 subunit of the signal recognition particle (SRP) is present in more than 20-fold excess over SRP in primate cells and exists primarily free but also in complex with small cytoplasmic Alu RNAs. (PubMed id 7542942)1, 2 Bovia F.... Strub K. (1995)
    6. Assembly of the Alu domain of the signal recognition particle (SRP): dimerization of the two protein components is required for efficient binding to SRP RNA. (PubMed id 2153922)1, 9 Strub K. and Walter P. (1990)
    7. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....Yanez-Mo M. (2013)
    8. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    9. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1 Cloutier P.... Coulombe B. (2013)
    10. Cleavage and polyadenylation specificity factor 1 (CPS F1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6. (PubMed id 23151878)1 Evsyukova I....Garcia-Blanco M.A. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6727 HGNC: 11299 AceView: SRP14 Ensembl:ENSG00000140319 euGenes: HUgn6727
    ECgene: SRP14 Kegg: 6727 H-InvDB: SRP14

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SRP14 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Signal_recognition_particle

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SRP14 gene:
    Search GeneIP for patents involving SRP14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SRP14  
     OriGene qPCR primer pairs and template standards for SRP14   OriGene Protein Over-expression Lysate for SRP14  
     OriGene MassSpec something-or-other for SRP14   OriGene clones in human, mouse for SRP14  
     OriGene qSTAR qPCR primer pairs in human, mouse for SRP14   OriGene Purified Protein for SRP14  
     OriGene ORF clones in mouse, rat for SRP14   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SRP14   OriGene Custom Protein Services for SRP14  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SRP14
     QIAGEN SeqTarget long-range PCR primers for resequencing SRP14
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRP14
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRP14
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRP14
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRP14
     GenScript Custom Purified and Recombinant Proteins Services for SRP14 GenScript cDNA clones with any tag delivered in your preferred vector for SRP14
     GenScript Custom Assay Services for SRP14 GenScript Custom Superior Antibodies Services for SRP14
     GenScript Custom overexpressing Cell Line Services for SRP14 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SRP14 promoter
     Search Chromatin IP Primers for SRP14
     RT2 qPCR Primer Assay in human, mouse, rat SRP14
     GNC Network for SRP14
     SABiosciences Custom PCR Arrays for SRP14
     Search Tocris compounds for SRP14
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SRP14 antibodies
     SRP14 proteins
     Antibodies for SRP14
     See all of Abcam's Antibodies, Kits and Proteins for SRP14
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for SRP14




     Proteins for SRP14
     Antibodies for SRP14
     ELISAs for SRP14
     CLIAs for SRP14
     Search LifeMap BioReagents cell lines for SRP14
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRP14
     SwitchGear 3'UTR luciferase reporter plasmids for SRP14
     SwitchGear Promoter luciferase reporter plasmids for SRP14
     ThermoFisher Antibodies for SRP14
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRP14
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SRP14
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SRP14
    Customized:
     lentivirus for stable overexpression of SRP14
     lentivirus expression plasmids for stable overexpression of SRP14
     adenovirus for overexpression of SRP14
     LSBio Antibodies in human, mouse, rat for SRP14
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SRP14 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4