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SRMS Gene(Protein Coding)

Src-Related Kinase Lacking C-Terminal Regulatory Tyrosine And N-Terminal Myristylation Sites

GCID:
GC20M063539
GIFtS:
45

Aliases for SRMS Gene

Aliases for SRMS Gene

  • Src-Related Kinase Lacking C-Terminal Regulatory Tyrosine And N-Terminal Myristylation Sites 2 3 5
  • EC 2.7.10.2 4 58
  • C20orf148 3 4
  • Chromosome 20 Open Reading Frame 148 2
  • Tyrosine-Protein Kinase Srms 3
  • DJ697K14.1 3
  • EC 2.7.10 58
  • PTK70 3
  • SRM 3

External Ids for SRMS Gene

Previous HGNC Symbols for SRMS Gene

  • C20orf148

Previous GeneCards Identifiers for SRMS Gene

  • GC00U990353
  • GC20M062009
  • GC20M062851
  • GC20M062899
  • GC20M062900
  • GC20M061642
  • GC20M062172
  • GC20M058902

Summaries for SRMS Gene

GeneCards Summary for SRMS Gene

SRMS (Src-Related Kinase Lacking C-Terminal Regulatory Tyrosine And N-Terminal Myristylation Sites) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Focal Adhesion. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is FGR.

UniProtKB/Swiss-Prot for SRMS Gene

  • Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues. May be involved in proliferation or differentiation of keratinocytes in the skin.

Additional gene information for SRMS Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRMS Gene

Genomics for SRMS Gene

Regulatory Elements for SRMS Gene

Enhancers for SRMS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20H063541 1.1 ENCODE dbSUPER 24.6 +4.9 4898 1 ATF1 BACH1 MAX EBF1 BATF ZIC2 GATA3 ATF7 ZSCAN29 RUNX3 SRMS PTK6 ENSG00000275812
GH20H063544 1.1 ENCODE dbSUPER 20.9 +2.1 2080 2 PKNOX1 ARID4B SIN3A KLF17 RAD21 GLIS2 RCOR1 THAP11 ZHX2 MXD4 PPDPF SRMS ENSG00000275812
GH20H063893 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -349.2 -349188 5 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 SLC30A9 ZNF766 ZNF143 DIDO1 UCKL1 MIR647 GMEB2 PRPF6 RGS19 RTEL1 OPRL1 ZBTB46 C20orf181
GH20H063680 1.5 Ensembl ENCODE dbSUPER 11.5 -139.8 -139799 13 HDGF PKNOX1 ZFP64 SIN3A ZBTB7B GLIS2 ELK1 FOS ZNF548 DEK LIME1 RTEL1 DIDO1 MIR647 UCKL1 ENSG00000237371 ZGPAT SLC2A4RG ENSG00000229299 FNDC11
GH20H063611 1.3 FANTOM5 Ensembl ENCODE dbSUPER 12 -65.2 -65221 1 CTCF POLR2A MAX FNDC11 SRMS PTK6 STMN3 RGS19 LIME1 OPRL1 GMEB2 HELZ2 TPD52L2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SRMS on UCSC Golden Path with GeneCards custom track

Genomic Location for SRMS Gene

Chromosome:
20
Start:
63,539,924 bp from pter
End:
63,547,504 bp from pter
Size:
7,581 bases
Orientation:
Minus strand

Genomic View for SRMS Gene

Genes around SRMS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRMS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRMS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRMS Gene

Proteins for SRMS Gene

  • Protein details for SRMS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H3Y6-SRMS_HUMAN
    Recommended name:
    Tyrosine-protein kinase Srms
    Protein Accession:
    Q9H3Y6

    Protein attributes for SRMS Gene

    Size:
    488 amino acids
    Molecular mass:
    54507 Da
    Quaternary structure:
    • Interacts (via the SH2 and SH3 domains) with DOK1.

neXtProt entry for SRMS Gene

Selected DME Specific Peptides for SRMS Gene

Q9H3Y6:
  • RDLAARN
  • KWTAPEA
  • AARNVLV
  • KSDVWSFG

Post-translational modifications for SRMS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SRMS Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for SRMS Gene

Suggested Antigen Peptide Sequences for SRMS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H3Y6

UniProtKB/Swiss-Prot:

SRMS_HUMAN :
  • The N-terminal region regulates its kinase activity.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Domain:
  • The N-terminal region regulates its kinase activity.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
genes like me logo Genes that share domains with SRMS: view

Function for SRMS Gene

Molecular function for SRMS Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function:
Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues. May be involved in proliferation or differentiation of keratinocytes in the skin.

Enzyme Numbers (IUBMB) for SRMS Gene

Phenotypes From GWAS Catalog for SRMS Gene

Gene Ontology (GO) - Molecular Function for SRMS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IDA,EXP 23822091
GO:0004715 non-membrane spanning protein tyrosine kinase activity IBA --
GO:0005102 receptor binding IBA --
GO:0005515 protein binding IPI 23822091
genes like me logo Genes that share ontologies with SRMS: view
genes like me logo Genes that share phenotypes with SRMS: view

Animal Models for SRMS Gene

MGI Knock Outs for SRMS:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SRMS
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SRMS Gene

Localization for SRMS Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRMS Gene

Cytoplasm. Note=Localizes to punctate cytoplasmic structures.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRMS gene
Compartment Confidence
cytosol 5
plasma membrane 3
mitochondrion 3
peroxisome 2
extracellular 1
cytoskeleton 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Cytosol (2)
  • Intermediate filaments (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SRMS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 23822091
GO:0005829 cytosol TAS --
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA --
genes like me logo Genes that share ontologies with SRMS: view

Pathways & Interactions for SRMS Gene

genes like me logo Genes that share pathways with SRMS: view

Gene Ontology (GO) - Biological Process for SRMS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA --
GO:0009968 negative regulation of signal transduction TAS --
GO:0016310 phosphorylation IEA --
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with SRMS: view

No data available for SIGNOR curated interactions for SRMS Gene

Drugs & Compounds for SRMS Gene

(1) Drugs for SRMS Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Nutra Agonist 0

(1) Additional Compounds for SRMS Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with SRMS: view

Transcripts for SRMS Gene

mRNA/cDNA for SRMS Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SRMS Gene

Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SRMS
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SRMS Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4
SP1: - -
SP2:
SP3: -

Relevant External Links for SRMS Gene

GeneLoc Exon Structure for
SRMS
ECgene alternative splicing isoforms for
SRMS

Expression for SRMS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SRMS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SRMS Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x4.2).

Protein differential expression in normal tissues from HIPED for SRMS Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SRMS Gene



Protein tissue co-expression partners for SRMS Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SRMS Gene:

SRMS

SOURCE GeneReport for Unigene cluster for SRMS Gene:

Hs.411061

mRNA Expression by UniProt/SwissProt for SRMS Gene:

Q9H3Y6-SRMS_HUMAN
Tissue specificity: Highly expressed in most breast cancers (at protein level).

Evidence on tissue expression from TISSUES for SRMS Gene

  • Bone marrow(2.3)
  • Gall bladder(2.3)
  • Intestine(2.3)
  • Lung(2.3)
  • Spleen(2.3)
  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with SRMS: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SRMS Gene

Orthologs for SRMS Gene

This gene was present in the common ancestor of animals.

Orthologs for SRMS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRMS 34 33
  • 99.18 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SRMS 33 34
  • 83.7 (n)
cow
(Bos Taurus)
Mammalia SRMS 33 34
  • 82.33 (n)
rat
(Rattus norvegicus)
Mammalia Srms 33
  • 80.58 (n)
mouse
(Mus musculus)
Mammalia Srms 33 16 34
  • 80.51 (n)
oppossum
(Monodelphis domestica)
Mammalia SRMS 34
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRMS 34
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves SRMS 33 34
  • 69.31 (n)
lizard
(Anolis carolinensis)
Reptilia SRMS 34
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491303 33
  • 57.25 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:194282 33
  • 54.17 (n)
SRMS 34
  • 44 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Src64B 34
  • 34 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea src-1 34
  • 34 (a)
ManyToMany
Species where no ortholog for SRMS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRMS Gene

ENSEMBL:
Gene Tree for SRMS (if available)
TreeFam:
Gene Tree for SRMS (if available)

Paralogs for SRMS Gene

Variants for SRMS Gene

Sequence variations from dbSNP and Humsavar for SRMS Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000288768 -- 63,541,688(+) ACCCA(C/T)GTCAC intron-variant
rs1000411296 -- 63,545,749(+) ACGCT(C/T)TGTCC intron-variant
rs1000484792 -- 63,546,045(+) TAGTC(-/T)TTTAA intron-variant
rs1000749498 -- 63,544,745(+) AAGCA(C/G)TGCTG intron-variant
rs1000841736 -- 63,549,236(+) GCCCC(-/CGA)CGCCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SRMS Gene

Variant ID Type Subtype PubMed ID
dgv35n64 CNV loss 17921354
dgv521n27 CNV loss 19166990
dgv522n27 CNV loss 19166990
dgv7667n54 CNV loss 21841781
dgv7668n54 CNV loss 21841781
esv2758806 CNV gain+loss 17122850
nsv1136564 CNV deletion 24896259
nsv180256 CNV insertion 16902084
nsv470563 CNV loss 18288195
nsv517702 CNV loss 19592680
nsv521734 CNV loss 19592680
nsv586569 CNV loss 21841781
nsv586571 CNV loss 21841781
nsv586573 CNV loss 21841781
nsv586574 CNV loss 21841781
nsv834033 CNV gain 17160897
nsv834034 CNV loss 17160897
nsv953306 CNV deletion 24416366
nsv9825 CNV gain 18304495

Variation tolerance for SRMS Gene

Residual Variation Intolerance Score: 98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.55; 94.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRMS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRMS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRMS Gene

Disorders for SRMS Gene

Relevant External Links for SRMS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRMS

No disorders were found for SRMS Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRMS Gene

Publications for SRMS Gene

  1. The unique N-terminal region of SRMS regulates enzymatic activity and phosphorylation of its novel substrate docking protein 1. (PMID: 23822091) Goel RK … Lukong KE (The FEBS journal 2013) 2 3 4 60
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 60
  3. A novel nonreceptor tyrosine kinase, Srm: cloning and targeted disruption. (PMID: 7935409) Kohmura N … Aizawa S (Molecular and cellular biology 1994) 2 3 60
  4. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J … Colwill K (Science signaling 2015) 3 60
  5. Protein-tyrosine Phosphatase and Kinase Specificity in Regulation of SRC and Breast Tumor Kinase. (PMID: 25897081) Fan G … Tonks NK (The Journal of biological chemistry 2015) 3 60

Products for SRMS Gene

Sources for SRMS Gene

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