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Aliases for SRMS Gene

Aliases for SRMS Gene

  • Src-Related Kinase Lacking C-Terminal Regulatory Tyrosine And N-Terminal Myristylation Sites 2 3
  • EC 2.7.10.2 4 63
  • C20orf148 3 4
  • Chromosome 20 Open Reading Frame 148 2
  • Tyrosine-Protein Kinase Srms 3
  • DJ697K14.1 3
  • EC 2.7.10 63
  • SRM 3

External Ids for SRMS Gene

Previous HGNC Symbols for SRMS Gene

  • C20orf148

Previous GeneCards Identifiers for SRMS Gene

  • GC00U990353
  • GC20M062009
  • GC20M062851
  • GC20M062899
  • GC20M062900
  • GC20M061642
  • GC20M062172
  • GC20M058902

Summaries for SRMS Gene

GeneCards Summary for SRMS Gene

SRMS (Src-Related Kinase Lacking C-Terminal Regulatory Tyrosine And N-Terminal Myristylation Sites) is a Protein Coding gene. Diseases associated with SRMS include metanephric adenoma. Among its related pathways are Downstream Signaling Events Of B Cell Receptor (BCR) and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include protein tyrosine kinase activity and non-membrane spanning protein tyrosine kinase activity. An important paralog of this gene is ABL2.

UniProtKB/Swiss-Prot for SRMS Gene

  • Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues. May be involved in proliferation or differentiation of keratinocytes in the skin.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRMS Gene

Genomics for SRMS Gene

Regulatory Elements for SRMS Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SRMS Gene

Start:
63,539,924 bp from pter
End:
63,547,504 bp from pter
Size:
7,581 bases
Orientation:
Minus strand

Genomic View for SRMS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SRMS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRMS Gene

Proteins for SRMS Gene

  • Protein details for SRMS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H3Y6-SRMS_HUMAN
    Recommended name:
    Tyrosine-protein kinase Srms
    Protein Accession:
    Q9H3Y6
    Secondary Accessions:

    Protein attributes for SRMS Gene

    Size:
    488 amino acids
    Molecular mass:
    54507 Da
    Quaternary structure:
    • Interacts (via the SH2 and SH3 domains) with DOK1.

neXtProt entry for SRMS Gene

Proteomics data for SRMS Gene at MOPED

Selected DME Specific Peptides for SRMS Gene

Post-translational modifications for SRMS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SRMS Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for SRMS Gene

Suggested Antigen Peptide Sequences for SRMS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H3Y6

UniProtKB/Swiss-Prot:

SRMS_HUMAN :
  • Q9H3Y6
Domain:
  • The N-terminal region regulates its kinase activity.
  • Contains 1 protein kinase domain.
  • Contains 1 SH2 domain.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
genes like me logo Genes that share domains with SRMS: view

Function for SRMS Gene

Molecular function for SRMS Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function: Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues. May be involved in proliferation or differentiation of keratinocytes in the skin.

Enzyme Numbers (IUBMB) for SRMS Gene

Gene Ontology (GO) - Molecular Function for SRMS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity IDA 23822091
GO:0004715 non-membrane spanning protein tyrosine kinase activity IBA --
GO:0005102 receptor binding IBA --
GO:0005515 protein binding IPI 23822091
genes like me logo Genes that share ontologies with SRMS: view
genes like me logo Genes that share phenotypes with SRMS: view

Animal Models for SRMS Gene

MGI Knock Outs for SRMS:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SRMS

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for SRMS Gene

Localization for SRMS Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRMS Gene

Cytoplasm. Note=Localizes to punctate cytoplasmic structures.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRMS Gene COMPARTMENTS Subcellular localization image for SRMS gene
Compartment Confidence
mitochondrion 3
peroxisome 2
cytoskeleton 1
cytosol 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SRMS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 23822091
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA --
genes like me logo Genes that share ontologies with SRMS: view

Pathways for SRMS Gene

genes like me logo Genes that share pathways with SRMS: view

Gene Ontology (GO) - Biological Process for SRMS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA --
GO:0016477 cell migration IBA --
GO:0030036 actin cytoskeleton organization IBA --
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with SRMS: view

Compounds for SRMS Gene

(2) HMDB Compounds for SRMS Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
genes like me logo Genes that share compounds with SRMS: view

Transcripts for SRMS Gene

mRNA/cDNA for SRMS Gene

(10) Selected AceView cDNA sequences:
(0) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SRMS Gene

Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SRMS

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRMS Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4
SP1: - -
SP2:
SP3: -

Relevant External Links for SRMS Gene

GeneLoc Exon Structure for
SRMS
ECgene alternative splicing isoforms for
SRMS

Expression for SRMS Gene

mRNA expression in normal human tissues for SRMS Gene

mRNA differential expression in normal tissues according to GTEx for SRMS Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SRMS Gene

SOURCE GeneReport for Unigene cluster for SRMS Gene Hs.411061

mRNA Expression by UniProt/SwissProt for SRMS Gene

Q9H3Y6-SRMS_HUMAN
Tissue specificity: Highly expressed in most breast cancers (at protein level)
genes like me logo Genes that share expressions with SRMS: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SRMS Gene

Orthologs for SRMS Gene

This gene was present in the common ancestor of animals.

Orthologs for SRMS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRMS 35
  • 99.18 (n)
  • 99.59 (a)
SRMS 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SRMS 35
  • 82.33 (n)
  • 79.5 (a)
SRMS 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRMS 35
  • 83.7 (n)
  • 80.49 (a)
SRMS 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srms 35
  • 80.51 (n)
  • 79.34 (a)
Srms 16
Srms 36
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SRMS 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRMS 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Srms 35
  • 80.58 (n)
  • 80.17 (a)
chicken
(Gallus gallus)
Aves SRMS 35
  • 69.31 (n)
  • 63.75 (a)
SRMS 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRMS 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491303 35
  • 57.25 (n)
  • 53.29 (a)
zebrafish
(Danio rerio)
Actinopterygii SRMS 36
  • 44 (a)
OneToOne
zgc:194282 35
  • 54.17 (n)
  • 45.63 (a)
fruit fly
(Drosophila melanogaster)
Insecta Src64B 36
  • 34 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea src-1 36
  • 34 (a)
ManyToMany
Species with no ortholog for SRMS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRMS Gene

ENSEMBL:
Gene Tree for SRMS (if available)
TreeFam:
Gene Tree for SRMS (if available)

Paralogs for SRMS Gene

Paralogs for SRMS Gene

genes like me logo Genes that share paralogs with SRMS: view

Variants for SRMS Gene

Sequence variations from dbSNP and Humsavar for SRMS Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs310650 -- 63,539,945(+) GAGAT(G/T)GAATC utr-variant-3-prime
rs310651 -- 63,539,992(+) CTGGG(C/G)ACCAT utr-variant-3-prime
rs310652 -- 63,540,068(-) GCGTA(C/G)GGGTC utr-variant-3-prime
rs310653 -- 63,540,203(-) GACAC(A/G)CTGGC utr-variant-3-prime
rs310654 - 63,540,916(+) GAGCA(A/C)GTAGA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SRMS Gene

Variant ID Type Subtype PubMed ID
nsv9825 CNV Gain 18304495
dgv4618n71 CNV Loss 21882294
dgv4631n71 CNV Loss 21882294
nsv913190 CNV Loss 21882294
dgv4633n71 CNV Loss 21882294
nsv834033 CNV Gain 17160897
dgv4634n71 CNV Loss 21882294
nsv913201 CNV Loss 21882294
dgv4635n71 CNV Gain+Loss 21882294
nsv834034 CNV Loss 17160897
nsv913207 CNV Loss 21882294
dgv1344e1 CNV Complex 17122850
dgv4637n71 CNV Loss 21882294
nsv913213 CNV Loss 21882294
nsv470563 CNV Loss 18288195
nsv913220 CNV Loss 21882294
dgv4640n71 CNV Loss 21882294
dgv4641n71 CNV Loss 21882294
dgv4642n71 CNV Loss 21882294
dgv521n27 CNV Loss 19166990
nsv521734 CNV Loss 19592680
dgv522n27 CNV Loss 19166990
dgv4643n71 CNV Loss 21882294
nsv913230 CNV Gain+Loss 21882294
dgv35n64 CNV Loss 17921354
nsv517702 CNV Loss 19592680
dgv4644n71 CNV Loss 21882294
nsv180256 CNV Insertion 16902084

Relevant External Links for SRMS Gene

HapMap Linkage Disequilibrium report
SRMS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRMS Gene

Disorders for SRMS Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SRMS Gene including...

Search for SRMS Gene in MalaCards »

(4) University of Copenhagen DISEASES for SRMS Gene

genes like me logo Genes that share disorders with SRMS: view

No data available for UniProtKB/Swiss-Prot for SRMS Gene

Publications for SRMS Gene

  1. A novel nonreceptor tyrosine kinase, Srm: cloning and targeted disruption. (PMID: 7935409) Kohmura N. … Aizawa S. (Mol. Cell. Biol. 1994) 2 3
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. The unique N-terminal region of SRMS regulates enzymatic activity and phosphorylation of its novel substrate docking protein 1. (PMID: 23822091) Goel R.K. … Lukong K.E. (FEBS J. 2013) 3 4
  4. Patterns of somatic mutation in human cancer genomes. (PMID: 17344846) Greenman C. … Stratton M.R. (Nature 2007) 4
  5. RAKing in AKT: a tumor suppressor function for the intracellular tyrosine kinase FRK. (PMID: 19652529) Brauer P.M. … Tyner A.L. (Cell Cycle 2009) 23

Products for SRMS Gene

Sources for SRMS Gene

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