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SRMS Gene

protein-coding   GIFtS: 55
GCID: GC20M062172

Src-Related Kinase Lacking C-Terminal Regulatory Tyrosine...

(Previous name: chromosome 20 open reading frame 148)
(Previous symbol: C20orf148)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Src-Related Kinase Lacking C-Terminal Regulatory Tyrosine And
N-Terminal Myristylation Sites1 2
     SRM2
C20orf1481 2 3     dJ697K14.12
EC 2.7.10.23 8     Tyrosine-Protein Kinase Srms2
Chromosome 20 Open Reading Frame 1481     EC 2.7.108

External Ids:    HGNC: 112981   Entrez Gene: 67252   Ensembl: ENSG000001255087   UniProtKB: Q9H3Y63   

Export aliases for SRMS gene to outside databases

Previous GC identifers: GC00U990353 GC20M062009 GC20M062851 GC20M062899 GC20M062900 GC20M061642 GC20M058902


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SRMS Gene:
SRMS (src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites) is a protein-coding gene. Diseases associated with SRMS include xanthogranulomatous pyelonephritis, and metanephric adenoma. GO annotations related to this gene include non-membrane spanning protein tyrosine kinase activity and protein tyrosine kinase activity. An important paralog of this gene is FRK.

UniProtKB/Swiss-Prot: SRMS_HUMAN, Q9H3Y6
Function: Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues. May be involved in
proliferation or differentiation of keratinocytes in the skin




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the SRMS gene promoter:
         Egr-3   NF-1   p53   AP-1   HTF   ATF-2   AREB6   S8   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSRMS promoter sequence
   Search Chromatin IP Primers for SRMS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SRMS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.33

SRMS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRMS gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M062172:  view genomic region     (about GC identifiers)

Start:
62,172,163 bp from pter      End:
62,178,857 bp from pter
Size:
6,695 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SRMS_HUMAN, Q9H3Y6 (See protein sequence)
Recommended Name: Tyrosine-protein kinase Srms  
Size: 488 amino acids; 54507 Da
Subunit: Interacts (via the SH2 and SH3 domains) with DOK1

Explore the universe of human proteins at neXtProt for SRMS: NX_Q9H3Y6

Explore proteomics data for SRMS at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for SRMS (Q9H3Y6)
     KWTAPEA  RDLAARN  AARNVLV  KSDVWSFG 


    See SRMS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_543013.1  
    ENSEMBL proteins: 
     ENSP00000217188  
    Reactome Protein details: Q9H3Y6

    SRMS Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for SRMS
    OriGene Custom MassSpec
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    GenScript Custom Purified and Recombinant Proteins Services for SRMS
    Novus Biologicals SRMS Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SRMS

    SRMS Antibody Products:

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    Novus Biologicals SRMS Antibody
    Abcam antibodies for SRMS
    Cloud-Clone Corp. Antibodies for SRMS
    ThermoFisher Antibodies for SRMS
    LSBio Antibodies in human, mouse, rat for SRMS

    SRMS Assay Products:

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    GenScript Custom Assay Services for SRMS
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SRMS
    Cloud-Clone Corp. CLIAs for SRMS


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SH2D: SH2 domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites
    Src family

    Selected InterPro protein domains (see all 8):
     IPR017441 Protein_kinase_ATP_BS
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR011009 Kinase-like_dom
     IPR000980 SH2
     IPR001452 SH3_domain

    Graphical View of Domain Structure for InterPro Entry Q9H3Y6

    ProtoNet protein and cluster: Q9H3Y6

    2 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: SRMS_HUMAN, Q9H3Y6
    Domain: The N-terminal region regulates its kinase activity (PubMed:23822091)
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SH3 domain


    SRMS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRMS_HUMAN, Q9H3Y6
    Function: Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues. May be involved in
    proliferation or differentiation of keratinocytes in the skin
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity IDA--
    GO:0004715non-membrane spanning protein tyrosine kinase activity IEA--
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
         
    SRMS for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for SRMS:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Gemcitabine induced cell-death  Increased S DNA content, incre 
     Increased mitotic index  Synthetic lethal with Ras 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Srms):
     normal 

    SRMS for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Srmstm1Sia for SRMS

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SRMS
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SRMS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SRMS
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SRMS

    miRNA
    Products:
        
    miRTarBase miRNAs that target SRMS:
    hsa-mir-423-5p (MIRT038148), hsa-mir-320a (MIRT044635), hsa-mir-744-5p (MIRT037588), hsa-mir-455-3p (MIRT037815), hsa-mir-7-5p (MIRT025815)

    Block miRNA regulation of human, mouse, rat SRMS using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SRMS
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SRMS
    Predesigned siRNA for gene silencing in human, mouse, rat SRMS

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SRMS

    Clone
    Products:
         
    OriGene clones in human, mouse for SRMS (see all 5)
    OriGene ORF clones in mouse, rat for SRMS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SRMS (NM_080823)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRMS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRMS

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for SRMS
    Browse ESI BIO Cell Lines and PureStem Progenitors for SRMS 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRMS


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SRMS_HUMAN, Q9H3Y6: Cytoplasm. Note=Localizes to punctate cytoplasmic structures
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion3
    peroxisome2
    cytoskeleton1
    cytosol1
    extracellular1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--

    SRMS for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SRMS About    
    See pathways by source

    SuperPathContained pathways About
    1Downstream Signaling Events Of B Cell Receptor (BCR)
    Signaling by the B Cell Receptor (BCR)0.79
    2Focal adhesion
    Focal Adhesion0.65
    3Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
    Antigen Activates B Cell Receptor Leading to Generation of Second Messengers0.47
    4Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SRMS
        Focal Adhesion

    1 Reactome Pathway for SRMS
        Antigen activates B Cell Receptor (BCR) leading to generation of second messengers



    SRMS for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SRMS
    Interactions:

        Search GeneGlobe Interaction Network for SRMS

    1 Interacting protein for SRMS (Q9H3Y61, 2) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DOK1Q997041, 2EBI-8541270,EBI-1384360 MINT-8433750 MINT-8433736 MINT-8433703 MINT-8433805 MINT-8433772 MINT-8433717 MINT-8433788
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0038083peptidyl-tyrosine autophosphorylation IDA--

    SRMS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SRMS

    2 HMDB Compounds for SRMS    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SRMS gene: 
    NM_080823.3  

    Unigene Cluster for SRMS:

    Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites
    Hs.411061  [show with all ESTs]
    Unigene Representative Sequence: NM_080823
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000217188(uc002yfi.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SRMS using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SRMS
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SRMS
    Predesigned siRNA for gene silencing in human, mouse, rat SRMS
    Clone
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    OriGene clones in human, mouse for SRMS (see all 5)
    OriGene ORF clones in mouse, rat for SRMS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SRMS (NM_080823)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRMS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRMS
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SRMS
    OriGene qSTAR qPCR primer pairs in human, mouse for SRMS
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SRMS
      QuantiTect SYBR Green Assays in human, mouse, rat SRMS
      QuantiFast Probe-based Assays in human, mouse, rat SRMS

    5 DOTS entries:

    DT.95341160  DT.120833226  DT.99947617  DT.92044841  DT.99981520 

    10 AceView cDNA sequences:

    NM_080823 BF762532 BF330815 BI835187 BM784153 BE066428 BE075993 BM742718 
    BF330886 BE075953 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SRMS    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4
    SP1:              -                       -         
    SP2:                                                
    SP3:              -                                 


    ECgene alternative splicing isoforms for SRMS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SRMS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGAGTGCT
    SRMS Expression
    About this image

    SRMS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SRMS Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.411061

    UniProtKB/Swiss-Prot: SRMS_HUMAN, Q9H3Y6
    Tissue specificity: Highly expressed in most breast cancers (at protein level)

        Custom PCR Arrays for SRMS
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    QuantiFast Probe-based Assays in human, mouse, rat SRMS
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRMS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SRMS gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srms1 , 5 src-related kinase lacking C-terminal regulatory tyrosine more1, 5 80.51(n)1
    79.34(a)1
      2 (103.62 cM)5
    208111  NM_011481.31  NP_035611.31 
     1812055625 
    chicken
    (Gallus gallus)
    Aves SRMS1 src-related kinase lacking C-terminal regulatory tyrosine more 69.31(n)
    63.75(a)
      419246  XM_417420.3  XP_417420.2 
    lizard
    (Anolis carolinensis)
    Reptilia SRMS6
    src-related kinase lacking C-terminal regulatory t...
    59(a)
    1 ↔ 1
    4(154347520-154393042)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004913031 tyrosine-protein kinase Srms-like 57.25(n)
    53.29(a)
      100491303  XM_002942385.2  XP_002942431.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1942821 zgc:194282 54.17(n)
    45.63(a)
      100192213  NM_001136250.2  NP_001129722.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Src64B6
    Src oncogene at 64B
    34(a)
    many ↔ many
    3L(4592447-4626196)
    worm
    (Caenorhabditis elegans)
    Secernentea src-16
    Protein SRC-1 (src-1) mRNA, complete cds
    34(a)
    many ↔ many
    I(1566931-1580196) WBGene00005077


    ENSEMBL Gene Tree for SRMS (if available)
    TreeFam Gene Tree for SRMS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SRMS gene
    FRK2  LCK2  BLK2  LYN2  FGR2  PTK62  YES12  HCK2  
    ABL12  SRC2  FYN2  ABL22  
    Selected SIMAP similar genes for SRMS using alignment to 1 protein entry:     SRMS_HUMAN(see all similar genes):
    EPHA2    FGR    EPHA5    EPHA6    FYN    BLK
    PTK6    SRC    FRK    HCK    FGFR4    EPHA3
    BMX    FGFR2    LYN    LCK    ABL2    BCR/ABL fusion

    SRMS for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SRMS (see all 393)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs560072921,2
    C--62140575(+) GTGTGC/GCTACC 1 -- us2k10--------
    rs1863996421,2
    --62171777(+) GCCTCC/GGAGGC 1 -- ds50010--------
    rs1916666111,2
    --62171849(+) ACGGGA/GAACGT 1 -- ds50010--------
    rs1496403591,2
    C--62171984(+) TGCACA/GGGGGA 1 -- ds50010--------
    rs1433698391,2
    --62172031(+) TGCACA/GAACAT 1 -- ds50010--------
    rs1834387781,2
    C--62172125(+) GGAGGA/GGGGGC 1 -- ds50010--------
    rs1463732711,2
    C--62172179(+) GGGGTG/AGCATC 2 /H /Y mis11Minor allele frequency- A:0.00NA 4528
    rs1860385291,2
    C--62172195(+) ATGGCA/GTGCAG 2 H syn10--------
    rs2001837031,2
    C--62172209(+) CTCCCG/ACAGCG 2 /R /W mis11Minor allele frequency- A:0.00EU 1185
    rs61221301,2
    C,F,A,H--62172219(+) GTGGCG/AAAGGA 2 /F syn19Minor allele frequency- A:0.18NA EA EU 5995

    HapMap Linkage Disequilibrium report for SRMS (62172163 - 62178857 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SRMS (see all 28):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv180256CNV Insertion16902084
    nsv517702CNV Loss19592680
    dgv4644n71CNV Loss21882294
    dgv521n27CNV Loss19166990
    nsv913213CNV Loss21882294
    dgv4618n71CNV Loss21882294
    dgv35n64CNV Loss17921354
    dgv4643n71CNV Loss21882294
    nsv913207CNV Loss21882294
    nsv521734CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SRMS
    DNA2.0 Custom Variant and Variant Library Synthesis for SRMS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    7 diseases for SRMS:    
    About MalaCards
    xanthogranulomatous pyelonephritis    metanephric adenoma    pyelonephritis    angiomyolipoma
    osteoarthritis    renal cell carcinoma    adenoma

    4 diseases from the University of Copenhagen DISEASES database for SRMS:
    Renal cell carcinoma     Angiomyolipoma     Osteoarthritis     Metanephric adenoma

    SRMS for disorders           About GeneDecksing


    Export disorders for SRMS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SRMS gene integrated from 10 sources:
    (articles sorted by number of sources associating them with SRMS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The unique N-terminal region of SRMS regulates enzymatic activity and phosphorylation of its novel substrate docking protein 1. (PubMed id 23822091)1, 2 Goel R.K....Lukong K.E. (FEBS J. 2013)
    2. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    3. A novel nonreceptor tyrosine kinase, Srm: cloning and targeted disruption. (PubMed id 7935409)1, 3 Kohmura N....Aizawa S. (Mol. Cell. Biol. 1994)
    4. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PubMed id 23535732)1 Eeles R.A....Easton D.F. (Nat. Genet. 2013)
    5. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)1 Persaud A....Rotin D. (Mol. Syst. Biol. 2009)
    6. Genome-scale RNAi screen for host factors required for HIV replication. (PubMed id 18976975)1 Zhou H....Espeseth A.S. (amp 2008)
    7. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (Nature 2007)
    8. RAKing in AKT: a tumor suppressor function for the intracellular tyrosine kinase FRK. (PubMed id 19652529)9 Brauer P.M. and Tyner A.L. (Cell Cycle 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6725 HGNC: 11298 AceView: SRMS Ensembl:ENSG00000125508 euGenes: HUgn6725
    ECgene: SRMS H-InvDB: SRMS

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SRMS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SRMS gene:
    Search GeneIP for patents involving SRMS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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