SRMS Gene
protein-coding GIFtS: 52
GCID: GC20M062172
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src-related kinase lacking C-terminal regulatory tyrosine...(Previous name: chromosome 20 open reading frame 148 )
(Previous symbol: C20orf148)
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Aliases
for SRMS gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Src-Related Kinase Lacking C-Terminal Regulatory Tyrosine And N-TerminalMyristylation Sites1 2 | | EC 2.7.10.23 8 | | C20orf1481 2 3 | | Chromosome 20 Open Reading Frame 1481 | | SRM1 2 | | Tyrosine-Protein Kinase Srms2 | | DJ697K14.11 | | EC 2.7.108 |
Export aliases for SRMS gene to outside databasesPrevious GC identifers: GC00U990353 GC20M062009 GC20M062851 GC20M062899 GC20M062900 GC20M061642 GC20M058902 |
Summaries
for SRMS gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SRMS_HUMAN, Q9H3Y6Function: May be involved in proliferation or differentiation of keratinocytes in the skin (By similarity)
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Genomic Views
for SRMS gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011333.6
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SRMS gene promoter:
Egr-3 NF-1 p53 AP-1 HTF ATF-2 AREB6 S8 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for SRMS
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRMS |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Ensembl cytogenetic band: 20q13.33 HGNC cytogenetic band: 20q13.33SRMS Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M062172: view genomic region
(about GC identifiers)
Start:
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62,172,163 bp from pter |
End:
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62,178,857 bp from pter |
Size:
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6,695 bases |
Orientation:
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minus strand |
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Proteins
for SRMS gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SRMS_HUMAN, Q9H3Y6 (See
protein sequence)Recommended Name: Tyrosine-protein kinase Srms Size: 488 amino acids; 54507 DaExplore the universe of human proteins at neXtProt for SRMS: NX_Q9H3Y6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H3Y6
4 DME Specific Peptides for SRMS (Q9H3Y6)
SRMS Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_543013.1
ENSEMBL proteins: ENSP00000217188
Human Recombinant Protein Products:
SRMS Antibody Products:
Assay Products for SRMS: |
Protein
Domains /
Families
for SRMS gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SRMS for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q9H3Y6ProtoNet protein and cluster: Q9H3Y6 2 Blocks protein families: IPB000980 SH2 domain signature IPB008266 Tyrosine protein kinase
UniProtKB/Swiss-Prot: SRMS_HUMAN, Q9H3Y6Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamilySimilarity: Contains 1 protein kinase domainSimilarity: Contains 1 SH2 domainSimilarity: Contains 1 SH3 domain |
Function
for SRMS gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SRMS_HUMAN, Q9H3Y6Function: May be involved in proliferation or differentiation of keratinocytes in the skin (By similarity)Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphateEnzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRMS (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRMS
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SRMS (NM_080823) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SRMS | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRMS |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRMS |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
IEA | -- | | GO:0005524 | ATP binding |
IEA | -- |
SRMS for ontologies About GeneDecksing
6 GenomeRNAi human phenotypes for SRMS:
Animal Models:
Mouse knock-out Srmstm1Sia for SRMS
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Srms):
SRMS for phenotypes About GeneDecksing
|
Pathways & Interactions
for SRMS gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Focal Adhesion | |
1  BioSystems Pathway for SRMS
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SRMS
|
Drugs & Compounds
for SRMS gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SRMS
2 HMDB Compounds for SRMS About this table
Search CenterWatch for drugs/clinical trials and news about SRMS
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Transcripts
for SRMS gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SRMS gene: NM_080823.2 Unigene Cluster for SRMS: Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites Hs.411061 [show with all ESTs]Unigene Representative Sequence: NM_0808231 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000217188(uc002yfi.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRMS (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRMS
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SRMS (NM_080823) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SRMS | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRMS |
5 DOTS entries: DT.95341160 DT.120833226 DT.99947617 DT.92044841 DT.99981520 10 AceView cDNA sequences: NM_080823 BF762532 BM784153 BI835187 BF330815 BE066428 BE075993 BM742718 BF330886 BE075953
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for SRMS About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 |
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| SP1: | | | | | - | | | | | | | | - | | | | |
| SP2: | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for SRMS
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Expression
for SRMS gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SRMS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGGAGTGCT
About this image
See SRMS Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SRMS
SOURCE GeneReport for Unigene cluster: Hs.411061
SABiosciences Custom PCR Arrays for SRMS
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SRMS
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SRMS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRMS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRMS | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRMS |
Orthologs
for SRMS gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SRMS gene from 4/14 species (see all 14) About this table
ENSEMBL Gene Tree for SRMS (if available)
TreeFam Gene Tree for SRMS (if available) |
Paralogs
for SRMS gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SRMS gene
- FRK2 LCK2 BLK2 ITK2 LYN2 YES12 TXK2 HCK2
- ABL12 BMX2 ABL22 TEC2 FGR2 PTK62 SRC2 FYN2
- BTK2
18/36 SIMAP similar genes for SRMS using alignment to 1 protein entry: SRMS_HUMAN(see all similar genes):EPHA2 FGR EPHA5 EPHA6 FYN BLK
PTK6 SRC FGFR4 FRK HCK EPHA3
BMX FGFR2 LYN LCK ABL2 BCR/ABL fusion
SRMS for paralogs About GeneDecksing
|
Genomic Variants
for SRMS gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SRMS (62172163 - 62178857 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 13 variations for SRMS
13 CNVs: 30136 31044 50713 30137 50714 5149 5150 53244 4107 53251 50712 10590 30135 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SRMS |
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Disorders
/ Diseases
for SRMS gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SRMS for disorders About GeneDecksing
4  diseases for SRMS: About MalaCardsxanthogranulomatous pyelonephritis angiomyolipoma pyelonephritis osteoarthritis
3 diseases from the University of Copenhagen DISEASES database for SRMS:Renal cell carcinoma Angiomyolipoma Osteoarthritis Export disorders for SRMS gene to outside databases
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Publications
for SRMS gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SRMS gene integrated from 9 sources:
(articles sorted by number of sources associating them with SRMS) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- A novel nonreceptor tyrosine kinase, Srm: cloning and targeted disruption. (PubMed id 7935409)1, 3 Kohmura N....Aizawa S. (1994)
- Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)1 Persaud A....Rotin D. (2009)
- Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)
- RAKing in AKT: a tumor suppressor function for the in tracellular tyrosine kinase FRK. (PubMed id 19652529)9 Brauer P.M. and Tyner A.L. (2009)
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External Searches for SRMS gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing SRMS gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SRMS gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SRMS gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SRMS | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SRMS gene:
Search GeneIP for patents involving SRMS
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SRMS gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SRMS | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SRMS | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SRMS | | | OriGene Protein Over-expression Lysate for SRMS | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SRMS | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRMS | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRMS | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SRMS | | OriGene Custom Protein Services for SRMS | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SRMS | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SRMS | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRMS | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRMS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRMS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRMS |
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 |  |  |  | |
| | | | Search Tocris compounds for SRMS |
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 | | | SRMS Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRMS |
|  |  |  | | | | ThermoFisher Antibodies for SRMS |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRMS |
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