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Aliases for SRM Gene

Aliases for SRM Gene

  • Spermidine Synthase 2 3
  • SPS1 3 4 6
  • Putrescine Aminopropyltransferase 3 4
  • EC 2.5.1.16 4 64
  • SRML1 3 4
  • SPDSY 3 4
  • Spermidine Synthase-1 3
  • EC 2.5.1 64
  • PAPT 3

External Ids for SRM Gene

Previous Symbols for SRM Gene

  • SRML1

Summaries for SRM Gene

Entrez Gene Summary for SRM Gene

  • The polyamines putrescine, spermine, and spermidine are ubiquitous polycationic mediators of cell growth and differentiation. Spermidine synthase is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. This enzyme catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor. [provided by RefSeq, Jul 2008]

GeneCards Summary for SRM Gene

SRM (Spermidine Synthase) is a Protein Coding gene. Diseases associated with SRM include malaria and sleeping sickness. Among its related pathways are Metabolism and Arginine and proline metabolism. GO annotations related to this gene include protein homodimerization activity and spermidine synthase activity.

UniProtKB/Swiss-Prot for SRM Gene

  • Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRM Gene

Genomics for SRM Gene

Genomic Location for SRM Gene

Start:
11,054,584 bp from pter
End:
11,060,034 bp from pter
Size:
5,451 bases
Orientation:
Minus strand

Genomic View for SRM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SRM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRM Gene

Regulatory Elements for SRM Gene

Proteins for SRM Gene

  • Protein details for SRM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19623-SPEE_HUMAN
    Recommended name:
    Spermidine synthase
    Protein Accession:
    P19623
    Secondary Accessions:
    • B1AKP9
    • Q15511

    Protein attributes for SRM Gene

    Size:
    302 amino acids
    Molecular mass:
    33825 Da
    Quaternary structure:
    • Homodimer or homotetramer.

    Three dimensional structures from OCA and Proteopedia for SRM Gene

neXtProt entry for SRM Gene

Proteomics data for SRM Gene at MOPED

Selected DME Specific Peptides for SRM Gene

Post-translational modifications for SRM Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys96, Lys135, and Lys277

Other Protein References for SRM Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for SRM Gene

Protein Domains for SRM Gene

UniProtKB/Swiss-Prot:

SPEE_HUMAN
Domain:
  • Contains 1 PABS (polyamine biosynthesis) domain.:
    • P19623
Family:
  • Belongs to the spermidine/spermine synthase family.:
    • P19623
genes like me logo Genes that share domains with SRM: view

No data available for Gene Families for SRM Gene

Function for SRM Gene

Molecular function for SRM Gene

GENATLAS Biochemistry: spermidine synthetase,polyamine biosynthesis
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=20 uM for putrescine {ECO:0000269 PubMed:17585781}; KM=0.9 uM for S-adenosylmethioninamine {ECO:0000269 PubMed:17585781};
UniProtKB/Swiss-Prot CatalyticActivity: S-adenosyl 3-(methylthio)propylamine + putrescine = 5-S-methyl-5-thioadenosine + spermidine.
UniProtKB/Swiss-Prot EnzymeRegulation: The activity is thought to be regulated mainly by the availability of decarboxylated S-adenosylmethionine
UniProtKB/Swiss-Prot Function: Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine.

Enzyme Numbers (IUBMB) for SRM Gene

Gene Ontology (GO) - Molecular Function for SRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004766 spermidine synthase activity IDA 17585781
GO:0016740 transferase activity --
GO:0042803 protein homodimerization activity IDA 17585781
genes like me logo Genes that share ontologies with SRM: view

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SRM Gene

Localization for SRM Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRM Gene COMPARTMENTS Subcellular localization image for SRM gene
Compartment Confidence
cytosol 4
nucleus 2
chloroplast 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SRM: view

Pathways for SRM Gene

genes like me logo Genes that share pathways with SRM: view

UniProtKB/Swiss-Prot P19623-SPEE_HUMAN

  • Pathway: Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1

Gene Ontology (GO) - Biological Process for SRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006595 polyamine metabolic process TAS --
GO:0008152 metabolic process --
GO:0008295 spermidine biosynthetic process IEA --
GO:0034641 cellular nitrogen compound metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with SRM: view

Compounds for SRM Gene

(6) HMDB Compounds for SRM Gene

Compound Synonyms Cas Number PubMed IDs
5'-Methylthioadenosine
  • 1-(6-amino-9H-purin-9-yl)-1-deoxy-5-S-methyl-5-thio-beta-D-Ribofuranose
2457-80-9
Cadaverine
  • 1,5-Diaminopentane
462-94-2
Putrescine
  • 1,4-Butanediamine
110-60-1
S-Adenosylmethioninamine
  • (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt
22365-13-5
Spermidine
  • 1,5,10-Triazadecane
124-20-9

(1) Drugbank Compounds for SRM Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
S-Adenosylmethionine
  • Acylcarnitine
29908-03-0 enzyme substrate

(13) Novoseek inferred chemical compound relationships for SRM Gene

Compound -log(P) Hits PubMed IDs
adodato 93.7 1
spermidine 93.3 92
1-aminooxy-3-aminopropane 89.7 1
s-adenosylmethionine 85.5 13
putrescine 84.9 5
genes like me logo Genes that share compounds with SRM: view

Transcripts for SRM Gene

mRNA/cDNA for SRM Gene

Unigene Clusters for SRM Gene

Spermidine synthase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SRM Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d
SP1: - - - -
SP2: - -
SP3: - - - -
SP4: -
SP5:
SP6:

Relevant External Links for SRM Gene

GeneLoc Exon Structure for
SRM
ECgene alternative splicing isoforms for
SRM

Expression for SRM Gene

mRNA expression in normal human tissues for SRM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SRM Gene

SOURCE GeneReport for Unigene cluster for SRM Gene Hs.76244

genes like me logo Genes that share expressions with SRM: view

Orthologs for SRM Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SRM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRM 36
  • 99.23 (n)
  • 99.67 (a)
SRM 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SRM 36
  • 90.73 (n)
  • 94.37 (a)
SRM 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRM 36
  • 90.55 (n)
  • 93.93 (a)
SRM 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srm 36
  • 88.85 (n)
  • 94.7 (a)
Srm 16
Srm 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SRM 37
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRM 37
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100912604 36
  • 89.18 (n)
  • 95.36 (a)
chicken
(Gallus gallus)
Aves SRM 36
  • 80.95 (n)
  • 89.05 (a)
SRM 37
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRM 37
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25559 36
tropical clawed frog
(Silurana tropicalis)
Amphibia srm 36
  • 74.86 (n)
  • 83.62 (a)
zebrafish
(Danio rerio)
Actinopterygii srm 36
  • 72.16 (n)
  • 80 (a)
srm 37
  • 79 (a)
OneToOne
zgc63600 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011126 36
  • 62.49 (n)
  • 57.84 (a)
fruit fly
(Drosophila melanogaster)
Insecta SpdS 36
  • 62.86 (n)
  • 56.07 (a)
SpdS 37
  • 55 (a)
OneToOne
CG8327 38
  • 55 (a)
worm
(Caenorhabditis elegans)
Secernentea spds-1 36
  • 58.7 (n)
  • 57.68 (a)
spds-1 37
  • 47 (a)
OneToOne
Y46G5A.19 38
  • 48 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL340W 36
  • 62.44 (n)
  • 55.28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPE3 36
  • 57.28 (n)
  • 58.1 (a)
SPE3 37
  • 56 (a)
OneToOne
SPE3 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B09372g 36
  • 58.57 (n)
  • 58.1 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2088 36
soybean
(Glycine max)
eudicotyledons Gma.2891 36
thale cress
(Arabidopsis thaliana)
eudicotyledons SPDS1 36
  • 55.48 (n)
  • 52.86 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.6371 36
corn
(Zea mays)
Liliopsida Zm.16536 36
rice
(Oryza sativa)
Liliopsida Os.4599 36
Os07g0408700 36
  • 54.44 (n)
  • 50.52 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.24743 36
bread mold
(Neurospora crassa)
Ascomycetes NCU06727 36
  • 66.55 (n)
  • 60.07 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC12C2.07c 36
  • 57.93 (n)
  • 56.29 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2167 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 58 (a)
OneToOne
Species with no ortholog for SRM:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for SRM Gene

ENSEMBL:
Gene Tree for SRM (if available)
TreeFam:
Gene Tree for SRM (if available)

Paralogs for SRM Gene

Pseudogenes.org Pseudogenes for SRM Gene

genes like me logo Genes that share paralogs with SRM: view

No data available for Paralogs for SRM Gene

Variants for SRM Gene

Sequence variations from dbSNP and Humsavar for SRM Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs13616 -- 11,054,883(-) CAGGC(A/C)CTGAA synonymous-codon, reference
rs743576 -- 11,059,120(+) GGCCT(C/T)GCTAG intron-variant
rs743577 -- 11,059,078(+) GCCGC(A/G)TCAGT intron-variant
rs1049932 - 11,056,694(-) CGAAG(C/G)TGACC reference, missense
rs1076859 -- 11,059,536(-) GAGCC(A/C)GAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRM Gene

Variant ID Type Subtype PubMed ID
nsv832425 CNV Loss 17160897
dgv137n71 CNV Loss 21882294
nsv871818 CNV Loss 21882294
nsv870986 CNV Loss 21882294

Relevant External Links for SRM Gene

HapMap Linkage Disequilibrium report
SRM

Disorders for SRM Gene

(1) University of Copenhagen DISEASES for SRM Gene

(7) Novoseek inferred disease relationships for SRM Gene

Disease -log(P) Hits PubMed IDs
trypanosomiasis african 67.4 1
leishmaniasis 32.4 1
chagas disease 30.2 1
malaria 23.4 3
lymphoma b-cell 20 2
genes like me logo Genes that share disorders with SRM: view

No data available for UniProtKB/Swiss-Prot for SRM Gene

Publications for SRM Gene

  1. Human spermidine synthase: cloning and primary structure. (PMID: 2344393) Wahlfors J. … Eloranta T. (DNA Cell Biol. 1990) 2 3 4 23
  2. Human spermidine synthase gene: structure and chromosomal localization. (PMID: 2069720) Myoehaenen S. … Jaenne J. (DNA Cell Biol. 1991) 3 4 23
  3. Structure and mechanism of spermidine synthases. (PMID: 17585781) Wu H. … Plotnikov A.N. (Biochemistry 2007) 3 4 23
  4. Inhibition of spermidine synthase gene expression by transforming growth factor-beta 1 in hepatoma cells. (PMID: 9020892) Nishikawa Y. … Carr B.I. (Biochem. J. 1997) 3 23
  5. Regulation of the human spermidine synthase mRNA translation by its 5'-untranslated region. (PMID: 7774716) Kauppinen L. (FEBS Lett. 1995) 3 23

Products for SRM Gene

  • Addgene plasmids for SRM

Sources for SRM Gene

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