SRM Gene
protein-coding GIFtS: 59
GCID: GC01M011114
|
|
spermidine synthase
(Previous symbol: SRML1)
| |
Aliases
for SRM gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Spermidine Synthase1 2 | | EC 2.5.1.163 8 | | SPS11 2 3 5 | | PAPT2 | | SRML11 2 3 | | Spermidine Synthase-12 | | Putrescine Aminopropyltransferase2 3 | | EC 2.5.18 | | SPDSY2 3 | | |
Export aliases for SRM gene to outside databasesPrevious GC identifers: GC01M011075 GC01M010958 GC01M010719 GC01M010824 GC01M011048 GC01M011037 GC01M010266 |
Summaries
for SRM gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SRM:
The polyamines putrescine, spermine, and spermidine are ubiquitous polycationic mediators of cell growth anddifferentiation. Spermidine synthase is one of four enzymes in the polyamine-biosynthetic pathway and carries out thefinal step of spermidine biosynthesis. This enzyme catalyzes the conversion of putrescine to spermidine usingdecarboxylated S-adenosylmethionine as the cofactor. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: SPEE_HUMAN, P19623Function: Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has astrong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely lowactivity towards spermidine
|
Genomic Views
for SRM gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_021937.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SRM gene promoter:
Max1 Max NRSF form 1 NRSF form 2 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for SRM
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRM |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36-p22 Ensembl cytogenetic band: 1p36.22 HGNC cytogenetic band: 1p36-p22SRM Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M011114: view genomic region
(about GC identifiers)
Start:
|
11,114,641 bp from pter |
End:
|
11,120,091 bp from pter |
Size:
|
5,451 bases |
Orientation:
|
minus strand |
|
Proteins
for SRM gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPEE_HUMAN, P19623 (See
protein sequence)Recommended Name: Spermidine synthase Size: 302 amino acids; 33825 Da
Subunit: Homodimer or homotetramer
5 PDB 3D structures from  and Proteopedia  for SRM:2O05 (3D)
2O06 (3D)
2O07 (3D)
2O0L (3D)
3RW9 (3D)
Secondary accessions: B1AKP9 Q15511Explore the universe of human proteins at neXtProt for SRM: NX_P19623
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P19623
4/5 DME Specific Peptides for SRM (P19623) (see all 5)
SRM Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003123.2
ENSEMBL proteins: ENSP00000366156 ENSP00000465966 ENSP00000467669 ENSP00000465687 ENSP00000468760 Reactome Protein details: P19623
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005829 | cytosol |
TAS | -- |
SRM for ontologies About GeneDecksing
SRM Antibody Products:
Assay Products for SRM: |
Protein
Domains /
Families
for SRM gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SRM for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P19623ProtoNet protein and cluster: P19623 1 Blocks protein family: IPB001045 Spermine synthase
UniProtKB/Swiss-Prot: SPEE_HUMAN, P19623Similarity: Belongs to the spermidine/spermine synthase family |
Function
for SRM gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SPEE_HUMAN, P19623Function: Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has astrong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely lowactivity towards spermidineCatalytic activity: S-adenosylmethioninamine + putrescine = 5'-S-methyl-5'-thioadenosine + spermidineEnzyme regulation: The activity is thought to be regulated mainly by the availability of decarboxylatedS-adenosylmethionineBiophysicochemical properties: Kinetic parameters: KM=20 uM for putrescine; KM=0.9 uM for S-adenosylmethioninamine; Genatlas biochemistry entry for SRM:spermidine synthetase,polyamine biosynthesis
Enzyme Numbers (IUBMB): EC 2.5.1.161 2 EC 2.5.12
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRM (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRM
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SRM (NM_003132) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SRM | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRM |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRM |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
SRM for ontologies About GeneDecksing
|
Pathways & Interactions
for SRM gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Metabolism | | | 2 | Arginine and proline metabolism | | | 3 | Metabolism of amino acids and derivatives | | | 4 | Nucleotide Metabolism | | | 5 | beta-Alanine metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3  BioSystems Pathways for SRM
3 
Reactome Pathways for SRM
5 
Kegg Pathways (Kegg details for SRM):
UniProtKB/Swiss-Prot: SPEE_HUMAN, P19623Pathway: Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1
SRM for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SRM
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/71 Interacting proteins for SRM (P196233 ENSP000003661564) via UniProtKB, MINT, STRING, and/or I2D (see all 71)
About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006595 | polyamine metabolic process |
TAS | -- | | GO:0008295 | spermidine biosynthetic process |
IEA | -- | | GO:0034641 | cellular nitrogen compound metabolic process |
TAS | -- | | GO:0044281 | small molecule metabolic process |
TAS | -- |
SRM for ontologies About GeneDecksing
|
Drugs & Compounds
for SRM gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SRM for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for SRM |
 Browse Tocris compounds for SRM
6 HMDB Compounds for SRM About this table
1 DrugBank Compound for SRM About this table
10/13 Novoseek chemical compound relationships for SRM gene (see all 13) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| adodato |
93.7 |
1 |
16428313 (1) |
| spermidine |
93.3 |
125 |
11870804 (8), 15913804 (8), 17585781 (4), 16428313 (3) (see all 50) |
| 1-aminooxy-3-aminopropane |
89.7 |
1 |
7896733 (1) |
| s-adenosylmethionine |
85.5 |
16 |
8787035 (1), 12843627 (1), 1930914 (1), 9020892 (1) (see all 13) |
| putrescine |
84.9 |
8 |
8343131 (1), 1525834 (1), 16472757 (1), 17585781 (1) (see all 5) |
| spermine |
84.3 |
14 |
7546290 (2), 8343131 (1), 14705926 (1), 1525834 (1) (see all 13) |
| ornithine |
80.8 |
14 |
20103728 (1), 8787035 (1), 17897063 (1), 1930914 (1) (see all 14) |
| 5-methylthioadenosine |
78 |
5 |
14705926 (1), 2292587 (1), 16472757 (1) |
| trypanothione |
75.9 |
18 |
17897063 (1), 17610127 (1), 18221178 (1) |
| propylamine |
71 |
1 |
16472757 (1) |
Search CenterWatch for drugs/clinical trials and news about SRM / SPEE
|
Transcripts
for SRM gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SRM gene: NM_003132.2 Unigene Cluster for SRM: Spermidine synthase Hs.76244 [show with all ESTs]Unigene Representative Sequence: BF6805446 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000475189 ENST00000376957(uc001arz.1) ENST00000490101 ENST00000465788
ENST00000459997 ENST00000487300
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRM (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRM
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SRM (NM_003132) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SRM | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRM |
Additional cDNA sequence: BC000309.2 BC033106.1 M34338.1 11 DOTS entries: DT.448003 DT.92341873 DT.99934540 DT.91771516 DT.100711264 DT.100817228 DT.100817236 DT.95302103 DT.95302109 DT.95302114 DT.97855068 24/483 AceView cDNA sequences (see all 483): BM701926 M78926 BQ014388 BU173278 AI626123 BM917512 BF434187 AU151507 BU189832 AI609154 AI299564 AA365918 BG327081 BQ053557 BU538810 CR605847 BE257169 BE280292 CA425146 CB159153 BM711303 BM553157 BC033106 BQ056697
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SRM (see all 6) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | · | 8d |
|---|
|
| SP1: | | | - | | | | | | | | | | - | | | | | | - | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | | | - | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SRM
|
Expression
for SRM gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SRM expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGTGCAGCA
About this image
See SRM Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SRM
SOURCE GeneReport for Unigene cluster: Hs.76244
SABiosciences Expression via Pathway-Focused PCR Array including SRM:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SRM
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SRM | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRM | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRM | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRM |
Orthologs
for SRM gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for SRM gene from 10/41 species (see all 41) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SRM1 |
spermidine synthase |
80.95(n)
89.05(a) |
|
771447 XM_001234727.2 XP_001234728.2 |
lizard
(Anolis carolinensis) |
Reptilia |
SRM6 |
-- |
86(a) |
1 ↔ 1 |
GL343615.1(89104-96146) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.255592 |
Xenopus laevis transcribed sequence with moderate similarity more |
76.77(n) |
|
BX855115.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc636002 |
similar to spermidine synthase |
73.44(n) |
|
394009 BC055159.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG83273
SpdS1 |
spermidine synthase3
Spermidine Synthase1 |
55(a)3
62.86(n)1
56.07(a)1 |
|
411671 NM_169298.21 NP_731384.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
Y46G5A.193
spds-11 |
spermidine synthesis3
Protein SPDS-11 |
48(a)3
58.7(n)1
57.68(a)1 |
|
II(12806802-12810690)3
1749141 NM_001136357.11 NP_001129829.11 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
SPE3(YPR069C)4
SPE31 |
Spermidine synthase, involved in biosynthesis of spermidine more4
Spe3p1 |
57.36(n)1
58.3(a)1 |
|
16(685437-684556)4
8561821, 4 NP_015394.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
SPDS11 |
spermidine synthase 1 |
55.48(n)
52.86(a) |
|
838993 NM_102230.4 NP_173794.2 |
rice
(Oryza sativa) |
Liliopsida |
Os.45992 |
Oryza sativa mRNA for spermidine synthase 1 (spdSyn1 more |
72.21(n) |
|
AK099606.1 |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
speE6 |
spermidine synthase (putrescine aminopropyltransfe... |
34(a) |
possible ortholog |
Chromosome(135598-136464) |
ENSEMBL Gene Tree for SRM (if available)
TreeFam Gene Tree for SRM (if available) |
Paralogs
for SRM gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SRM gene
SRM for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for SRM
PGOHUM00000247820 PGOHUM00000247667 PGOHUM00000240286
|
Genomic Variants
for SRM gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SRM (11114641 - 11120091 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SRM: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SRM |
|
Disorders
/ Diseases
for SRM gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SRM for disorders About GeneDecksing
OMIM gene information: 182891
OMIM disorders: --
14  diseases for SRM: About MalaCardssleeping sickness b-cell lymphomas chagas disease trypanosomiasis
leishmaniasis cholestasis myeloma cholera
pneumonia malaria hepatitis leukemia
prostatitis lymphoid leukemia
7 Novoseek disease relationships for SRM gene About this table
Export disorders for SRM gene to outside databases
|
Publications
for SRM gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SRM gene, integrated from 9 sources (see all 67):
(articles sorted by number of sources associating them with SRM) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human spermidine synthase: cloning and primary structure. (PubMed id 2344393)1, 2, 3, 9 Wahlfors J....Eloranta T. (1990)
- Structure and mechanism of spermidine synthases. (PubMed id 17585781)1, 2, 9 Wu H....Plotnikov A.N. (2007)
- Human spermidine synthase gene: structure and chromosomal localization. (PubMed id 2069720)1, 2, 9 Myoehaenen S.... Jaenne J. (1991)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Androgen regulation of spermidine synthase expression in the rat prostate. (PubMed id 11870804)7, 9 Cyriac J....Wang Z. (2002)
- Synthetic decarboxylated S-adenosyl-L-methionine as a substrate for aminopropyl transferases. (PubMed id 12843627)7, 9 Dejima H....Samejima K. (2003)
- Inhibition of spermidine synthase gene expression by transforming growth factor-beta 1 in hepatoma cells. (PubMed id 9020892)1, 9 Nishikawa Y....Carr B.I. (1997)
- Regulation of the human spermidine synthase mRNA translation by its 5'-untranslated region. (PubMed id 7774716)1, 9 Kauppinen L. (1995)
- Transgenic mice over-expressing the human spermidine synthase gene. (PubMed id 8343131)1, 9 Kauppinen L....Janne J. (1993)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
|
External Searches for SRM gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SRM gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SRM gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SRM gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SRM | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SRM gene:
Search GeneIP for patents involving SRM
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SRM gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SRM | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SRM | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SRM | | | OriGene Protein Over-expression Lysate for SRM | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SRM | | OriGene 3'-UTR Clone for SRM | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRM | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRM | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SRM | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SRM | | OriGene Custom Protein Services for SRM | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SRM | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SRM | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRM | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRM | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRM | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRM |
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| | | | Search Tocris compounds for SRM |
| |  |  |  |  | | | | | | Recombinant Protein for SRM |
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 | | | SRM Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRM |
|  |  |  | | | | Search ThermoFisher Antibodies for SRM |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRM |
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