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SRL Gene

protein-coding   GIFtS: 47
GCID: GC16M004239

Sarcalumenin

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
sarcalumenin1 2

External Ids:    HGNC: 112951   Entrez Gene: 63452   Ensembl: ENSG000001857397   OMIM: 6049925   UniProtKB: Q86TD43   

Export aliases for SRL gene to outside databases

Previous GC identifers: GC16U990054 GC16M004242 GC16M004182


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SRL Gene:
SRL (sarcalumenin) is a protein-coding gene. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is REPS1.

UniProtKB/Swiss-Prot: SRCA_HUMAN, Q86TD4
Function: May be involved in the regulation of calcium transport




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010393.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the SRL gene promoter:
         AML1a   Tal-1   p53   MyoD   E47   YY1   PPAR-gamma1   c-Myb   PPAR-gamma2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SRL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SRL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

SRL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRL gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M004239:  view genomic region     (about GC identifiers)

Start:
4,239,375 bp from pter      End:
4,292,081 bp from pter
Size:
52,707 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SRCA_HUMAN, Q86TD4 (See protein sequence)
Recommended Name: Sarcalumenin precursor  
Size: 932 amino acids; 100788 Da
Sequence caution: Sequence=CAD89901.1; Type=Frameshift; Positions=927;
Alternative splicing: 2 isoforms:  Q86TD4-1   Q86TD4-2   

Explore the universe of human proteins at neXtProt for SRL: NX_Q86TD4

Explore proteomics data for SRL at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn99, Asn740, Asn848
  • Modification sites at PhosphoSitePlus

  • See SRL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001092284.1  
    ENSEMBL proteins: 
     ENSP00000461179   ENSP00000382518   ENSP00000440350  

    SRL Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for SRL

     
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    Search eBioscience for ELISAs for SRL 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001401 Dynamin_GTPase
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q86TD4

    ProtoNet protein and cluster: Q86TD4


    Find genes that share domains with SRL           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRCA_HUMAN, Q86TD4
    Function: May be involved in the regulation of calcium transport

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005525GTP binding IEA--
         
    Find genes that share ontologies with SRL           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Srl):
     cardiovascular system  muscle 

    Find genes that share phenotypes with SRL           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Srltm1Hta for SRL

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SRL
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SRL
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SRL

    miRNA
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    miRTarBase miRNAs that target SRL:
    hsa-mir-335-5p (MIRT017390), hsa-mir-18a-3p (MIRT040951)

    Block miRNA regulation of human, mouse, rat SRL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SRL (see all 42):
    hsa-miR-345 hsa-miR-1197 hsa-miR-513a-5p hsa-miR-128 hsa-miR-3921 hsa-miR-4330 hsa-miR-497* hsa-miR-186*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SRL

    Gene Editing
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SRCA_HUMAN, Q86TD4: Sarcoplasmic reticulum lumen (By similarity). Note=Associated through calcium with the
    membrane (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum2
    extracellular2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0033018sarcoplasmic reticulum lumen IEA--

    Find genes that share ontologies with SRL           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SRL
    Interactions:

        Search GeneGlobe Interaction Network for SRL

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for SRL (ENSP000003825184) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NUMBENSP000003471694STRING: ENSP00000347169
    NUMBLENSP000002528914STRING: ENSP00000252891
    RANBP3ENSP000003414834STRING: ENSP00000341483
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SRL (SRCA)

    1 HMDB Compound for SRL    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    4 Novoseek inferred chemical compound relationships for SRL gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ryanodine 56.1 2 10398759 (1), 12959958 (1)
    dihydropyridine 55.7 1 12959958 (1)
    calcium 41.1 11 14678011 (2), 15276652 (2), 12959958 (1), 16178054 (1) (see all 6)
    atp 11.2 2 8647283 (1)



    Find genes that share compounds with SRL           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SRL gene: 
    NM_001098814.1  

    Unigene Cluster for SRL:

    Sarcalumenin
    Hs.10041  [show with all ESTs]
    Unigene Representative Sequence: BX647476
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000572111(uc002cvy.4) ENST00000399609(uc002cvz.4) ENST00000537996

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SRL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SRL (see all 42):
    hsa-miR-345 hsa-miR-1197 hsa-miR-513a-5p hsa-miR-128 hsa-miR-3921 hsa-miR-4330 hsa-miR-497* hsa-miR-186*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SRL
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SRL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SRL
      QuantiTect SYBR Green Assays in human, mouse, rat SRL
      QuantiFast Probe-based Assays in human, mouse, rat SRL

    Additional mRNA sequence: 

    AK056588.1 AK302601.1 AL831973.2 AL832361.1 BX647476.1 

    5 DOTS entries:

    DT.209634  DT.40260918  DT.100748234  DT.120703974  DT.92416631 

    Selected AceView cDNA sequences (see all 40):

    BF055359 F30239 F29975 F31328 AI685625 F32555 BE219044 AA418481 
    AI217685 AI887906 AK056588 F20632 BX103206 AA346041 F20502 AW964205 
    AA993197 AL831973 BM675369 BM682126 AI341730 AA346042 BF842337 AL832361 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SRL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTCCTTTT
    SRL Expression
    About this image


    SRL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Adipose (Muscoskeletal System)
             Interscapular Brown Adipose Depot
     
     Heart (Cardiovascular System)
     
     Skeletal Muscle (Muscoskeletal System)
    SRL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SRL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.10041
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SRL gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srl1 , 5 sarcalumenin1, 5 88.64(n)1
    96.48(a)1
      16 (2.44 cM)5
    1063931  NM_175347.41  NP_780556.21 
     44802165 
    chicken
    (Gallus gallus)
    Aves SRL1 sarcalumenin 83(n)
    89.62(a)
      396269  NM_205329.1  NP_990660.1 
    lizard
    (Anolis carolinensis)
    Reptilia SRL6
    sarcalumenin
    76(a)
    1 ↔ 1
    GL343856.1(69861-83042)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.331382 Xenopus laevis transcribed sequence with weak similarity more 78.27(n)    CF289376.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb80c092 wufb80c09 78.79(n)   323056  57043408 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG92976
    --
    21(a)
    1 ↔ 1
    3R(9597217-9605039)
    worm
    (Caenorhabditis elegans)
    Secernentea rme-16
    Protein RME-1, isoform b
    16(a)
    1 ↔ 1
    V(6208840-6217641) WBGene00004373


    ENSEMBL Gene Tree for SRL (if available)
    TreeFam Gene Tree for SRL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SRL gene
    REPS12  EPS15L12  EHD32  REPS22  EHD22  EHD12  EHD42  ITSN12  
    EPS152  ITSN22  
    4 SIMAP similar genes for SRL using alignment to 4 protein entries:     SRCA_HUMAN (see all proteins):
    EHD3    EHD1    EHD4    EHD2

    Find genes that share paralogs with SRL           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SRL (see all 1659)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1826465121,2
    --4238878(+) AACGAC/TCTCTG 1 -- int10--------
    rs1174103771,2
    C,F--4238939(+) AGTCAA/GGGACG 1 -- int11Minor allele frequency- G:0.01NA 120
    rs1872046131,2
    --4238976(+) CAAGCA/GGGAGG 1 -- int10--------
    rs1912424661,2
    --4239176(+) AGGACA/GCCACG 1 -- int10--------
    rs800986751,2
    F--4239334(+) GATGAA/TGAGAG 1 -- int11Minor allele frequency- T:0.02WA 118
    rs1468589021,2
    C--4239368(+) AAGCAC/TGCGGT 1 -- int10--------
    rs1405929251,2
    --4239397(+) CTTTAC/TTGAGA 1 -- ut310--------
    rs1838776941,2
    --4239440(+) AGGTTC/GTGCCA 1 -- ut310--------
    rs1456768821,2
    --4239675(+) ATGACG/TGAAAG 1 -- ut310--------
    rs1886448941,2
    --4239817(+) ACACAG/TTTGTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SRL (4239375 - 4292081 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for SRL:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2750428CNV Deletion23290073
    esv2671113CNV Deletion23128226
    esv2671997CNV Deletion23128226
    esv2750427CNV Deletion23290073
    nsv527866CNV Loss19592680
    nsv524305CNV Loss19592680
    esv2751608CNV Gain17911159
    esv21490CNV Gain+Loss19812545
    dgv794e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604992    OMIM disorders: --


    Find genes that share disorders with SRL           About GenesLikeMe

    1 Novoseek inferred disease relationship for SRL gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    muscular dystrophies 50.8 1 14678011 (1)

    Genetic Association Database (GAD): SRL

    Export disorders for SRL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SRL gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with SRL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of cDNA encoding a lumenal calcium binding glycoprotein from sarcoplasmic reticulum. (PubMed id 2762314)1, 3 Leberer E....MacLennan D.H. (Proc. Natl. Acad. Sci. U.S.A. 1989)
    2. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    3. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Identification of 4370 expressed sequence tags from a 3'-end-specific cDNA library of human skeletal muscle by DNA sequencing and filter hybridization. (PubMed id 8681137)1 Lanfranchi G....Valle G. (Genome Res. 1996)
    7. Drastic reduction of sarcalumenin in Dp427 (dystrophin of 427 kDa)-deficient fibres indicates that abnormal calcium handling plays a key role in muscular dystrophy. (PubMed id 14678011)9 Dowling P....Ohlendieck K. (Biochem. J. 2004)
    8. Drastic reduction in the luminal Ca2+ -binding proteins calsequestrin and sarcalumenin in dystrophin-deficient cardiac muscle. (PubMed id 15276652)9 Lohan J. and Ohlendieck K. (Biochim. Biophys. Acta 2004)
    9. Role of the eye muscles in thyroid eye disease: identification of the principal autoantigens. (PubMed id 9669297)9 Gunji K....Wall J.R. (Thyroid 1998)
    10. The identification of the phosphorylated 150/160-kDa proteins of sarcoplasmic reticulum, their kinase and their association with the ryanodine receptor. (PubMed id 8765099)9 Shoshan-Barmatz V....Heilmeyer L.M. (Biochim. Biophys. Acta 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6345 HGNC: 11295 AceView: SRL Ensembl:ENSG00000185739 euGenes: HUgn6345
    ECgene: SRL H-InvDB: SRL

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SRL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SRL gene:
    Search GeneIP for patents involving SRL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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