Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SRL Gene

protein-coding   GIFtS: 44
GCID: GC16M004239

Sarcalumenin

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
sarcalumenin1 2

External Ids:    HGNC: 112951   Entrez Gene: 63452   Ensembl: ENSG000001857397   OMIM: 6049925   UniProtKB: Q86TD43   

Export aliases for SRL gene to outside databases

Previous GC identifers: GC16U990054 GC16M004242 GC16M004182


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SRL Gene: 
SRL (sarcalumenin) is a protein-coding gene. Diseases associated with SRL include frey syndrome, and malignant hyperthermia. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is REPS1.

UniProtKB/Swiss-Prot: SRCA_HUMAN, Q86TD4
Function: May be involved in the regulation of calcium transport




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SRL gene promoter:
         AML1a   Tal-1   p53   MyoD   E47   YY1   PPAR-gamma1   c-Myb   PPAR-gamma2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SRL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

SRL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRL gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M004239:  view genomic region     (about GC identifiers)

Start:
4,239,375 bp from pter      End:
4,292,081 bp from pter
Size:
52,707 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SRCA_HUMAN, Q86TD4 (See protein sequence)
Recommended Name: Sarcalumenin precursor  
Size: 932 amino acids; 100788 Da
Subcellular location: Sarcoplasmic reticulum lumen (By similarity). Note=Associated through calcium with the
membrane (By similarity)
Sequence caution: Sequence=CAD89901.1; Type=Frameshift; Positions=927;
Alternative splicing: 2 isoforms:  Q86TD4-1   Q86TD4-2   

Explore the universe of human proteins at neXtProt for SRL: NX_Q86TD4

Explore proteomics data for SRL at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86TD4

  • SRL Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SRL Protein Expression
    REFSEQ proteins: NP_001092284.1  
    ENSEMBL proteins: 
     ENSP00000461179   ENSP00000382518   ENSP00000440350  

    Human Recombinant Protein Products for SRL: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SRL
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SRL
    GenScript Custom Purified and Recombinant Proteins Services for SRL
    Novus Biologicals SRL Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SRL 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0033018sarcoplasmic reticulum lumen IEA--

    SRL for ontologies           About GeneDecksing



    SRL Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SRL
    GenScript Custom Superior Antibodies Services for SRL
    Novus Biologicals SRL Antibodies
    Abcam antibodies for SRL
    Cloud-Clone Corp. Antibodies for SRL 
    ThermoFisher Antibodies for SRL
    LSBio Antibodies in human, mouse, rat for SRL 

    Assay Products for SRL: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SRL
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SRL
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SRL 
    Cloud-Clone Corp. CLIAs for SRL


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR001401 Dynamin_GTPase
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q86TD4

    ProtoNet protein and cluster: Q86TD4


    SRL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRCA_HUMAN, Q86TD4
    Function: May be involved in the regulation of calcium transport

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005525GTP binding IEA--
         
    SRL for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Srl):
     cardiovascular system  muscle 

    SRL for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Srltm1Hta for SRL

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SRL 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SRL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SRL 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SRL 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SRL
    8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate SRL (see all 42):
    hsa-miR-345 hsa-miR-1197 hsa-miR-513a-5p hsa-miR-128 hsa-miR-3921 hsa-miR-4330 hsa-miR-497* hsa-miR-186*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SRL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRL

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SRL
    Sirion Biotech Customized adenovirus for overexpression of SRL

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SRL (see all 7)
    OriGene ORF clones in mouse, rat for SRL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for SRL
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRL
    Sirion Biotech Customized lentivirus for stable overexpression of SRL 
                         Customized lentivirus expression plasmids for stable overexpression of SRL 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SRL
    Search LifeMap BioReagents cell lines for SRL
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRL


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SRL

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SRL for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SRL (SRCA)

    1 HMDB Compound for SRL    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    4 Novoseek inferred chemical compound relationships for SRL gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ryanodine 56.1 2 10398759 (1), 12959958 (1)
    dihydropyridine 55.7 1 12959958 (1)
    calcium 41.1 11 14678011 (2), 15276652 (2), 12959958 (1), 16178054 (1) (see all 6)
    atp 11.2 2 8647283 (1)

    Search CenterWatch for drugs/clinical trials and news about SRL / SRCA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SRL gene: 
    NM_001098814.1  

    Unigene Cluster for SRL:

    Sarcalumenin
    Hs.10041  [show with all ESTs]
    Unigene Representative Sequence: BX647476
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000572111(uc002cvy.4) ENST00000399609(uc002cvz.4) ENST00000537996

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SRL
    8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate SRL (see all 42):
    hsa-miR-345 hsa-miR-1197 hsa-miR-513a-5p hsa-miR-128 hsa-miR-3921 hsa-miR-4330 hsa-miR-497* hsa-miR-186*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SRL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRL
    Clone
    Products:
         
    OriGene clones in human, mouse for SRL (see all 7)
    OriGene ORF clones in mouse, rat for SRL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for SRL
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRL
    Sirion Biotech Customized lentivirus for stable overexpression of SRL 
                         Customized lentivirus expression plasmids for stable overexpression of SRL 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SRL
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SRL
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRL
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRL

    Additional mRNA sequence: 

    AK056588.1 AK302601.1 AL831973.2 AL832361.1 BX647476.1 

    5 DOTS entries:

    DT.209634  DT.40260918  DT.100748234  DT.120703974  DT.92416631 

    24/40 AceView cDNA sequences (see all 40):

    AI217685 AA418481 AI887906 F31328 BE219044 F32555 AI685625 BF055359 
    F29975 F30239 F20632 AK056588 F26773 AI341730 F20502 BM675369 
    BX647476 BF842337 AL831973 AA993197 AL832361 BM682126 AA346041 AA346042 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SRL expression in normal human tissues (normalized intensities)      SRL embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTCCTTTT
    SRL Expression
    About this image


    SRL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             skeletal muscle ; myocytes   
             cavities and their linings/intraembryonic coelom/diaphragm   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Heart (Cardiovascular System)
             heart muscle ; myocytes   

    See SRL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SRL

    SOURCE GeneReport for Unigene cluster: Hs.10041
        SABiosciences Custom PCR Arrays for SRL
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SRL
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SRL
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRL
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRL
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SRL gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srl1 , 5 sarcalumenin1, 5 88.64(n)1
    96.48(a)1
      16 (2.44 cM)5
    1063931  NM_175347.41  NP_780556.21 
     44802165 
    chicken
    (Gallus gallus)
    Aves SRL1 sarcalumenin 82.48(n)
    88.3(a)
      396269  NM_205329.1  NP_990660.1 
    lizard
    (Anolis carolinensis)
    Reptilia SRL6
    sarcalumenin
    76(a)
    1 ↔ 1
    GL343856.1(69861-83042)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.331382 Xenopus laevis transcribed sequence with weak similarity more 78.27(n)    CF289376.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb80c092 wufb80c09 78.79(n)   323056  57043408 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG92971 CG9297 56.5(n)
    46.1(a)
      41688  NM_176497.1  NP_788674.1 


    ENSEMBL Gene Tree for SRL (if available)
    TreeFam Gene Tree for SRL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SRL gene
    REPS12  EPS15L12  EHD32  REPS22  EHD22  EHD12  EHD42  ITSN12  
    EPS152  ITSN22  
    4 SIMAP similar genes for SRL using alignment to 4 protein entries:     SRCA_HUMAN (see all proteins):
    EHD3    EHD1    EHD4    EHD2

    SRL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1659 SNPs in SRL are shown (see all 1659)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1826465121,2
    --4238878(+) AACGAC/TCTCTG 1 -- int10--------
    rs1174103771,2
    C,F--4238939(+) AGTCAA/GGGACG 1 -- int11Minor allele frequency- G:0.01NA 120
    rs1872046131,2
    --4238976(+) CAAGCA/GGGAGG 1 -- int10--------
    rs1912424661,2
    --4239176(+) AGGACA/GCCACG 1 -- int10--------
    rs800986751,2
    F--4239334(+) GATGAA/TGAGAG 1 -- int11Minor allele frequency- T:0.02WA 118
    rs1468589021,2
    C--4239368(+) AAGCAC/TGCGGT 1 -- int10--------
    rs1405929251,2
    --4239397(+) CTTTAC/TTGAGA 1 -- ut310--------
    rs1838776941,2
    --4239440(+) AGGTTC/GTGCCA 1 -- ut310--------
    rs1456768821,2
    --4239675(+) ATGACG/TGAAAG 1 -- ut310--------
    rs1886448941,2
    --4239817(+) ACACAG/TTTGTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SRL (4239375 - 4292081 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for SRL:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2750428CNV Deletion23290073
    esv2671113CNV Deletion23128226
    esv2671997CNV Deletion23128226
    esv2750427CNV Deletion23290073
    nsv527866CNV Loss19592680
    nsv524305CNV Loss19592680
    esv2751608CNV Gain17911159
    esv21490CNV Gain+Loss19812545
    dgv794e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SRL
    DNA2.0 Custom Variant and Variant Library Synthesis for SRL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604992    OMIM disorders: --

    7 diseases for SRL:    About MalaCards
    frey syndrome    malignant hyperthermia    malignant hyperthermia susceptibility    eye disease
    muscular dystrophy    myopathy    thyroiditis


    SRL for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for SRL gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    muscular dystrophies 50.8 1 14678011 (1)

    Genetic Association Database (GAD): SRL

    Export disorders for SRL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SRL gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with SRL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of cDNA encoding a lumenal calcium binding glycoprotein from sarcoplasmic reticulum. (PubMed id 2762314)1, 3 Leberer E....MacLennan D.H. (1989)
    2. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
    3. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    6. Identification of 4370 expressed sequence tags from a 3'-end-specific cDNA library of human skeletal muscle by DNA sequencing and filter hybridization. (PubMed id 8681137)1 Lanfranchi G....Valle G. (1996)
    7. Drastic reduction of sarcalumenin in Dp427 (dystrophin of 427 kDa)-deficient fibres indicates that abnormal calcium handling plays a key role in muscular dystrophy. (PubMed id 14678011)9 Dowling P....Ohlendieck K. (2004)
    8. Drastic reduction in the luminal Ca2+ -binding proteins calsequestrin and sarcalumenin in dystrophin-deficient cardiac muscle. (PubMed id 15276652)9 Lohan J. and Ohlendieck K. (2004)
    9. Role of the eye muscles in thyroid eye disease: identification of the principal autoantigens. (PubMed id 9669297)9 Gunji K....Wall J.R. (1998)
    10. The identification of the phosphorylated 150/160-kDa proteins of sarcoplasmic reticulum, their kinase and their association with the ryanodine receptor. (PubMed id 8765099)9 Shoshan-Barmatz V....Heilmeyer L.M. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6345 HGNC: 11295 AceView: SRL Ensembl:ENSG00000185739 euGenes: HUgn6345
    ECgene: SRL H-InvDB: SRL

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SRL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SRL gene:
    Search GeneIP for patents involving SRL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SRL  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for SRL  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SRL  
     OriGene qSTAR qPCR primer pairs in human, mouse for SRL   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SRL   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SRL   OriGene Custom Protein Services for SRL  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SRL
     QIAGEN SeqTarget long-range PCR primers for resequencing SRL
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRL
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRL
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRL
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRL
     GenScript Custom Purified and Recombinant Proteins Services for SRL GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for SRL
     GenScript Custom Assay Services for SRL GenScript Custom Superior Antibodies Services for SRL
     GenScript Custom overexpressing Cell Line Services for SRL CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SRL promoter
     Search Chromatin IP Primers for SRL
     RT2 qPCR Primer Assay in human, mouse, rat SRL
     Search GNC Networks for SRL
     SABiosciences Custom PCR Arrays for SRL
     Search Tocris compounds for SRL (SRCA)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SRL antibodies
     SRL lysates
     Antibodies for SRL
     See all of Abcam's Antibodies, Kits and Proteins for SRL
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for SRL
     Antibodies for SRL
     ELISAs for SRL
     CLIAs for SRL
     Search LifeMap BioReagents cell lines for SRL
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRL
     Browse SwitchGear 3'UTR luciferase reporter plasmids for SRL
     Browse SwitchGear Promoter luciferase reporter plasmids for SRL
     ThermoFisher Antibodies for SRL
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRL
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SRL
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SRL
    Customized:
     lentivirus for stable overexpression of SRL
     lentivirus expression plasmids for stable overexpression of SRL
     adenovirus for overexpression of SRL
     LSBio Antibodies in human, mouse, rat for SRL
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SRL gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4