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Aliases for SRI Gene

Aliases for SRI Gene

  • Sorcin 2 3 5
  • 22 KDa Protein 3 4
  • CP-22 3 4
  • CP22 3 4
  • V19 3 4
  • Calcium Binding Protein Amplified In Mutlidrug-Resistant Cells 3
  • H_RG167B05.1 3
  • SCN 3

External Ids for SRI Gene

Previous GeneCards Identifiers for SRI Gene

  • GC07M086370
  • GC07M087432
  • GC07M087447
  • GC07M087446
  • GC07M087479
  • GC07M087672
  • GC07M087834
  • GC07M082444

Summaries for SRI Gene

Entrez Gene Summary for SRI Gene

  • This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene. [provided by RefSeq, Mar 2012]

GeneCards Summary for SRI Gene

SRI (Sorcin) is a Protein Coding gene. Diseases associated with SRI include Interstitial Myocarditis and Apical Myocardial Infarction. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Ion channel transport. GO annotations related to this gene include calcium ion binding and receptor binding. An important paralog of this gene is CAPNS2.

UniProtKB/Swiss-Prot for SRI Gene

  • Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels.

Gene Wiki entry for SRI Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRI Gene

Genomics for SRI Gene

Regulatory Elements for SRI Gene

Enhancers for SRI Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SRI on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the SRI gene promoter:

Genomic Location for SRI Gene

88,205,115 bp from pter
88,226,993 bp from pter
21,879 bases
Minus strand

Genomic View for SRI Gene

Genes around SRI on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRI Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRI Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRI Gene

Proteins for SRI Gene

  • Protein details for SRI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8MTH6
    • B4DKK2
    • D6W5Q0

    Protein attributes for SRI Gene

    198 amino acids
    Molecular mass:
    21676 Da
    Quaternary structure:
    • Homodimer. Interacts with GCA, RYR2 and ANXA7.
    • This protein has been shown to bind calcium with high affinity.
    • This protein is encoded by an amplified gene in multidrug-resistant cells.

    Three dimensional structures from OCA and Proteopedia for SRI Gene

    Alternative splice isoforms for SRI Gene


neXtProt entry for SRI Gene

Proteomics data for SRI Gene at MOPED

Post-translational modifications for SRI Gene

  • Ubiquitination at Lys 127
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for SRI Gene

Domains & Families for SRI Gene

Gene Families for SRI Gene

Protein Domains for SRI Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 EF-hand domains.
  • Contains 4 EF-hand domains.
genes like me logo Genes that share domains with SRI: view

Function for SRI Gene

Molecular function for SRI Gene

GENATLAS Biochemistry:
sorcin,calcium binding protein (22kDa),overexpressed in multidrug resistant lines
UniProtKB/Swiss-Prot Function:
Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels.
genes like me logo Genes that share phenotypes with SRI: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SRI Gene

Localization for SRI Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRI Gene

Cytoplasm. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=Relocates to the sarcoplasmic reticulum membrane in response to elevated calcium levels.

Subcellular locations from

Jensen Localization Image for SRI Gene COMPARTMENTS Subcellular localization image for SRI gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
extracellular 5
nucleus 5
plasma membrane 5
mitochondrion 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SRI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 16130169
GO:0005739 mitochondrion IEA --
GO:0030315 T-tubule TAS 17699613
GO:0031982 vesicle IEA --
GO:0042584 colocalizes_with chromaffin granule membrane IDA 9268363
genes like me logo Genes that share ontologies with SRI: view

Pathways & Interactions for SRI Gene

genes like me logo Genes that share pathways with SRI: view

Pathways by source for SRI Gene

SIGNOR curated interactions for SRI Gene

Other effect:

Gene Ontology (GO) - Biological Process for SRI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006816 calcium ion transport IEA --
GO:0006942 regulation of striated muscle contraction TAS 9668070
GO:0008016 regulation of heart contraction TAS 9668070
GO:0010649 regulation of cell communication by electrical coupling TAS 17699613
GO:0042994 cytoplasmic sequestering of transcription factor IEA --
genes like me logo Genes that share ontologies with SRI: view

Drugs & Compounds for SRI Gene

(9) Drugs for SRI Gene - From: ClinicalTrials, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
belimumab Approved Pharma Therapeutic Antibodies 45
calcium Nutra 0
Antibodies Pharma 5531
Immunoglobulins Pharma 5531
Immunologic Factors Pharma 23243

(1) Additional Compounds for SRI Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SRI: view

Transcripts for SRI Gene

Unigene Clusters for SRI Gene

Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SRI Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b
SP1: - - - -
SP2: - - -
SP3: - - - - - -
SP4: -
SP5: -

Relevant External Links for SRI Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SRI Gene

mRNA expression in normal human tissues for SRI Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SRI Gene

This gene is overexpressed in Bone (16.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SRI Gene

SOURCE GeneReport for Unigene cluster for SRI Gene Hs.489040

mRNA Expression by UniProt/SwissProt for SRI Gene

Tissue specificity: Detected in cardiac myocytes.
genes like me logo Genes that share expression patterns with SRI: view

Protein tissue co-expression partners for SRI Gene

- Elite partner

No data available for mRNA differential expression in normal tissues for SRI Gene

Orthologs for SRI Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SRI Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SRI 35
  • 94.84 (n)
  • 99.45 (a)
SRI 36
  • 98 (a)
(Canis familiaris)
Mammalia SRI 35
  • 93.6 (n)
  • 98.99 (a)
SRI 36
  • 85 (a)
(Mus musculus)
Mammalia Sri 35
  • 87.54 (n)
  • 95.96 (a)
Sri 16
Sri 36
  • 96 (a)
(Pan troglodytes)
Mammalia SRI 35
  • 99.83 (n)
  • 100 (a)
SRI 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Sri 35
  • 85.35 (n)
  • 91.92 (a)
(Monodelphis domestica)
Mammalia SRI 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia SRI 36
  • 82 (a)
(Gallus gallus)
Aves SRI 35
  • 78.62 (n)
  • 83.84 (a)
SRI 36
  • 83 (a)
(Anolis carolinensis)
Reptilia SRI 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sri 35
  • 73.73 (n)
  • 78.24 (a)
Str.6127 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.25824 35
(Danio rerio)
Actinopterygii sri 35
  • 69.98 (n)
  • 77.48 (a)
zgc64070 35
sri 36
  • 73 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9248 35
fruit fly
(Drosophila melanogaster)
Insecta CG17765 36
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PEF1 36
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
Species with no ortholog for SRI:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SRI Gene

Gene Tree for SRI (if available)
Gene Tree for SRI (if available)

Paralogs for SRI Gene

Paralogs for SRI Gene

(11) SIMAP similar genes for SRI Gene using alignment to 6 proteins: Pseudogenes for SRI Gene

genes like me logo Genes that share paralogs with SRI: view

Variants for SRI Gene

Sequence variations from dbSNP and Humsavar for SRI Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1046192 -- 88,205,691(-) TGATA(C/T)ATCCA utr-variant-3-prime
rs1063964 -- 88,206,154(-) TGAGA(C/T)ACTAA utr-variant-3-prime
rs6961480 -- 88,207,304(+) CAAGG(A/G)GACTG intron-variant
rs6964163 -- 88,210,948(+) GTACA(C/T)ACATA intron-variant
rs1804476 -- 88,209,352(-) AAACT(G/T)AGGGC reference, synonymous-codon

Variation tolerance for SRI Gene

Residual Variation Intolerance Score: 58.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRI Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SRI Gene

Disorders for SRI Gene

MalaCards: The human disease database

(5) MalaCards diseases for SRI Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
interstitial myocarditis
apical myocardial infarction
  • acute sore throat
hereditary spherocytosis
  • spherocytosis, type 1
neuropathy, congenital hypomyelinating
  • dejerine-sottas disease
- elite association - COSMIC cancer census association via MalaCards
Search SRI in MalaCards View complete list of genes associated with diseases

Relevant External Links for SRI

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SRI: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SRI Gene

Publications for SRI Gene

  1. Purification, cDNA cloning, and expression of human sorcin in vincristine-resistant HOB1 lymphoma cell lines. (PMID: 8561500) Lee W.P. (Arch. Biochem. Biophys. 1996) 3 4 23 67
  2. [Influence of tetrandrine on SORCIN gene expression in K562/A02 cell line]. (PMID: 18315902) Li J. … Shen H.L. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2008) 3 23
  3. [Correlation of sorcin overexpression to multidrug resistance of human gastric cancer cell line SGC7901]. (PMID: 18423116) He Q.C. … Cao W.J. (Ai Zheng 2008) 3 23
  4. Expression of a sorcin missense mutation in the heart modulates excitation-contraction coupling. (PMID: 17130302) Collis L.P. … Fishman G.I. (FASEB J. 2007) 3 23
  5. Knock-down of sorcin induces up-regulation of MDR1 in HeLa cells. (PMID: 17541155) Kawakami M. … Sakaeda T. (Biol. Pharm. Bull. 2007) 3 23

Products for SRI Gene

Sources for SRI Gene