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Aliases for SRI Gene

Aliases for SRI Gene

  • Sorcin 2 3 3 5
  • 22 KDa Protein 3 4
  • CP-22 3 4
  • CP22 3 4
  • V19 3 4
  • Calcium Binding Protein Amplified In Mutlidrug-Resistant Cells 3
  • H_RG167B05.1 3
  • SCN 3

External Ids for SRI Gene

Previous GeneCards Identifiers for SRI Gene

  • GC07M086370
  • GC07M087432
  • GC07M087447
  • GC07M087446
  • GC07M087479
  • GC07M087672
  • GC07M087834
  • GC07M082444

Summaries for SRI Gene

Entrez Gene Summary for SRI Gene

  • This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene. [provided by RefSeq, Mar 2012]

GeneCards Summary for SRI Gene

SRI (Sorcin) is a Protein Coding gene. Diseases associated with SRI include Apical Myocardial Infarction and Interstitial Myocarditis. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Ion channel transport. GO annotations related to this gene include calcium ion binding and receptor binding. An important paralog of this gene is GCA.

UniProtKB/Swiss-Prot for SRI Gene

  • Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels.

Gene Wiki entry for SRI Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRI Gene

Genomics for SRI Gene

Regulatory Elements for SRI Gene

Enhancers for SRI Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G088224 1.2 Ensembl ENCODE 13 +0.7 659 3.5 HNRNPUL1 FOXA2 YY1 FOS DEK ZHX2 ZNF579 MBD2 MAFF STAT3 SRI ENSG00000228113
GH07G088217 1.1 ENCODE 12.7 +7.4 7441 4.1 HDGF PKNOX1 CREB3L1 WRNIP1 SIN3A ZBTB7B YY1 ZNF766 CBX5 ZNF143 SRI ENSG00000228113
GH07G088228 0.5 ENCODE 12.9 -2.5 -2549 2.1 TRIM24 ATF2 TRIM28 SRI ENSG00000228113 GC07M088230
GH07G088200 0.5 ENCODE 11.7 +26.0 26013 0.2 POLR2A SMARCA4 MAX ZIC2 SRI GC07P088199 PIR58316 GC07M088203
GH07G088357 0.9 Ensembl ENCODE 4.9 -131.1 -131144 0.9 CTCF HLF TRIM22 BRCA1 RAD21 NR2F2 RFX5 JUND ATF3 HNF4G SRI PIR57969 STEAP4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SRI on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the SRI gene promoter:

Genomic Location for SRI Gene

88,205,115 bp from pter
88,226,993 bp from pter
21,879 bases
Minus strand

Genomic View for SRI Gene

Genes around SRI on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRI Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRI Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRI Gene

Proteins for SRI Gene

  • Protein details for SRI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8MTH6
    • B4DKK2
    • D6W5Q0

    Protein attributes for SRI Gene

    198 amino acids
    Molecular mass:
    21676 Da
    Quaternary structure:
    • Homodimer. Interacts with GCA, RYR2 and ANXA7.
    • This protein has been shown to bind calcium with high affinity.
    • This protein is encoded by an amplified gene in multidrug-resistant cells.

    Three dimensional structures from OCA and Proteopedia for SRI Gene

    Alternative splice isoforms for SRI Gene


neXtProt entry for SRI Gene

Post-translational modifications for SRI Gene

  • Ubiquitination at posLast=127127
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SRI

No data available for DME Specific Peptides for SRI Gene

Domains & Families for SRI Gene

Gene Families for SRI Gene

Protein Domains for SRI Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SRI: view

No data available for UniProtKB/Swiss-Prot for SRI Gene

Function for SRI Gene

Molecular function for SRI Gene

GENATLAS Biochemistry:
sorcin,calcium binding protein (22kDa),overexpressed in multidrug resistant lines
UniProtKB/Swiss-Prot Function:
Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels.

Gene Ontology (GO) - Molecular Function for SRI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 10748169
GO:0004198 calcium-dependent cysteine-type endopeptidase activity IBA --
GO:0005102 receptor binding TAS 9668070
GO:0005246 calcium channel regulator activity TAS 9668070
GO:0005509 calcium ion binding IDA 17215369
genes like me logo Genes that share ontologies with SRI: view
genes like me logo Genes that share phenotypes with SRI: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SRI Gene

Localization for SRI Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRI Gene

Cytoplasm. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=Relocates to the sarcoplasmic reticulum membrane in response to elevated calcium levels.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRI gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
endoplasmic reticulum 5
cytosol 5
mitochondrion 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SRI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm TAS 16130169
GO:0005739 mitochondrion IEA --
GO:0005789 endoplasmic reticulum membrane IDA 10672515
genes like me logo Genes that share ontologies with SRI: view

Pathways & Interactions for SRI Gene

genes like me logo Genes that share pathways with SRI: view

Pathways by source for SRI Gene

SIGNOR curated interactions for SRI Gene

Other effect:

Gene Ontology (GO) - Biological Process for SRI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001508 action potential TAS 9668070
GO:0006508 proteolysis IBA --
GO:0006810 transport TAS 9668070
GO:0006816 calcium ion transport IEA --
GO:0006880 intracellular sequestering of iron ion TAS 9668070
genes like me logo Genes that share ontologies with SRI: view

Drugs & Compounds for SRI Gene

(8) Drugs for SRI Gene - From: ClinicalTrials, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
belimumab Approved Pharma Therapeutic Antibodies 48
calcium Nutra 0
Antibodies Pharma 6394
Immunoglobulins Pharma 6394
Immunosuppressive Agents Pharma 13086

(1) Additional Compounds for SRI Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SRI: view

Transcripts for SRI Gene

Unigene Clusters for SRI Gene

Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRI Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b
SP1: - - - -
SP2: - - -
SP3: - - - - - -
SP4: -
SP5: -

Relevant External Links for SRI Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SRI Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SRI Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SRI Gene

This gene is overexpressed in Bone (16.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SRI Gene

Protein tissue co-expression partners for SRI Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SRI Gene:


SOURCE GeneReport for Unigene cluster for SRI Gene:


mRNA Expression by UniProt/SwissProt for SRI Gene:

Tissue specificity: Detected in cardiac myocytes.

Evidence on tissue expression from TISSUES for SRI Gene

  • Nervous system(5)
  • Intestine(4.7)
  • Liver(4.4)
  • Skin(4.3)
  • Muscle(2.8)
  • Heart(2.7)
  • Kidney(2.4)
  • Blood(2.3)
  • Lung(2.3)
  • Bone marrow(2.1)
genes like me logo Genes that share expression patterns with SRI: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRI Gene

Orthologs for SRI Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SRI Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SRI 34 35
  • 99.83 (n)
(Bos Taurus)
Mammalia SRI 34 35
  • 94.84 (n)
(Canis familiaris)
Mammalia SRI 34 35
  • 93.6 (n)
(Mus musculus)
Mammalia Sri 34 16 35
  • 87.54 (n)
(Rattus norvegicus)
Mammalia Sri 34
  • 85.35 (n)
(Ornithorhynchus anatinus)
Mammalia SRI 35
  • 82 (a)
(Monodelphis domestica)
Mammalia SRI 35
  • 81 (a)
(Gallus gallus)
Aves SRI 34 35
  • 78.62 (n)
(Anolis carolinensis)
Reptilia SRI 35
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sri 34
  • 73.73 (n)
Str.6127 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.25824 34
(Danio rerio)
Actinopterygii sri 34 35
  • 69.98 (n)
zgc64070 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9248 34
fruit fly
(Drosophila melanogaster)
Insecta CG17765 35
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PEF1 35
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 39 (a)
Species where no ortholog for SRI was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SRI Gene

Gene Tree for SRI (if available)
Gene Tree for SRI (if available)

Paralogs for SRI Gene

Paralogs for SRI Gene

(11) SIMAP similar genes for SRI Gene using alignment to 6 proteins: Pseudogenes for SRI Gene

genes like me logo Genes that share paralogs with SRI: view

Variants for SRI Gene

Sequence variations from dbSNP and Humsavar for SRI Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs869312940 Pathogenic 88,210,926(-) TAACA(A/G)CTTTT splice-acceptor-variant
rs1000317431 -- 88,221,600(+) ACTGC(A/C)GAATT intron-variant, upstream-variant-2KB
rs1000369871 -- 88,221,128(+) ACATT(G/T)AAAGG intron-variant, upstream-variant-2KB
rs1000410837 -- 88,224,814(+) ATCAA(C/T)CACAG intron-variant
rs1000477239 -- 88,227,323(+) AGCCT(A/T)TTTTC intron-variant, upstream-variant-2KB

Variation tolerance for SRI Gene

Residual Variation Intolerance Score: 58.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRI Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SRI Gene

Disorders for SRI Gene

MalaCards: The human disease database

(5) MalaCards diseases for SRI Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
apical myocardial infarction
interstitial myocarditis
charcot-marie-tooth disease, axonal, type 2l
  • charcot-marie-tooth disease axonal type 2l
hereditary spherocytosis
  • spherocytosis, type 1
neuropathy, congenital hypomyelinating
  • dejerine-sottas disease
- elite association - COSMIC cancer census association via MalaCards
Search SRI in MalaCards View complete list of genes associated with diseases

Relevant External Links for SRI

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SRI: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SRI Gene

Publications for SRI Gene

  1. The PEF family proteins sorcin and grancalcin interact in vivo and in vitro. (PMID: 12804766) Hansen C. … Berchtold M.W. (FEBS Lett. 2003) 3 4 22 64
  2. Crystal structure of calcium-free human sorcin: a member of the penta-EF-hand protein family. (PMID: 11714909) Xie X. … Botfield M.C. (Protein Sci. 2001) 3 4 22 64
  3. Purification, cDNA cloning, and expression of human sorcin in vincristine-resistant HOB1 lymphoma cell lines. (PMID: 8561500) Lee W.P. (Arch. Biochem. Biophys. 1996) 3 4 22 64
  4. Isolation and molecular cloning of human sorcin a calcium-binding protein in vincristine-resistant HOB1 lymphoma cells. (PMID: 7873602) Wang S.L. … Kao M.C. (Biochim. Biophys. Acta 1995) 3 4 22 64
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64

Products for SRI Gene

Sources for SRI Gene

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