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SRI Gene

protein-coding   GIFtS: 60
GCID: GC07M087834

Sorcin

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
sorcin1 2     V192 3
22 KDa Protein2 3     SCN2 5
CP-222 3     H_RG167B05.12
CP222 3     Calcium Binding Protein Amplified In Mutlidrug-Resistant Cells2

External Ids:    HGNC: 112921   Entrez Gene: 67172   Ensembl: ENSG000000751427   OMIM: 1825205   UniProtKB: P306263   

Export aliases for SRI gene to outside databases

Previous GC identifers: GC07M086370 GC07M087432 GC07M087447 GC07M087446 GC07M087479 GC07M087672 GC07M082444


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SRI Gene:
This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to
the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular
calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results
in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene. (provided
by RefSeq, Mar 2012)

GeneCards Summary for SRI Gene:
SRI (sorcin) is a protein-coding gene. GO annotations related to this gene include receptor binding and calcium ion binding. An important paralog of this gene is PEF1.

UniProtKB/Swiss-Prot: SORCN_HUMAN, P30626
Function: Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to
calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels

Gene Wiki entry for SRI Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SRI gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): SRI promoter sequence
   Search Chromatin IP Primers for SRI

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SRI


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.1   Ensembl cytogenetic band:  7q21.12   HGNC cytogenetic band: 7q21.1

SRI Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRI gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M087834:  view genomic region     (about GC identifiers)

Start:
87,834,432 bp from pter      End:
87,856,308 bp from pter
Size:
21,877 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 87,165,789-87,187,665     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SORCN_HUMAN, P30626 (See protein sequence)
Recommended Name: Sorcin  
Size: 198 amino acids; 21676 Da
Subunit: Homodimer. Interacts with GCA, RYR2 and ANXA7
Miscellaneous: This protein is encoded by an amplified gene in multidrug-resistant cells
Miscellaneous: This protein has been shown to bind calcium with high affinity
2 PDB 3D structures from and Proteopedia for SRI:
1JUO (3D)        2JC2 (3D)    
Secondary accessions: A8MTH6 D6W5Q0
Alternative splicing: 2 isoforms:  P30626-1   P30626-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SRI: NX_P30626

Explore proteomics data for SRI at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys127
  • Modification sites at PhosphoSitePlus

  • See SRI Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001243820.1  NP_001243821.1  NP_003121.1  NP_944490.1  

    ENSEMBL proteins: 
     ENSP00000265729   ENSP00000397609   ENSP00000418512   ENSP00000378137   ENSP00000391148  
     ENSP00000415271  

    SRI Human Recombinant Protein Products:

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    Novus Biologicals SRI Lysates
    Sino Biological Recombinant Protein for SRI
    Sino Biological Cell Lysate for SRI
    ProSpec Recombinant Protein for SRI
    Cloud-Clone Corp. Proteins for SRI

     
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    antibodies-online proteins for SRI (8 products) 

     
    antibodies-online peptides for SRI

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    antibodies-online kits for SRI (5 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing

    3 InterPro protein domains:
     IPR018247 EF_Hand_1_Ca_BS
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom

    Graphical View of Domain Structure for InterPro Entry P30626

    ProtoNet protein and cluster: P30626

    UniProtKB/Swiss-Prot: SORCN_HUMAN, P30626
    Similarity: Contains 4 EF-hand domains


    Find genes that share domains with SRI           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SORCN_HUMAN, P30626
    Function: Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to
    calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels

         Genatlas biochemistry entry for SRI:
    sorcin,calcium binding protein (22kDa),overexpressed in multidrug resistant lines

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IPI10748169
    GO:0004198calcium-dependent cysteine-type endopeptidase activity IBA--
    GO:0005102receptor binding TAS9668070
    GO:0005246calcium channel regulator activity TAS9668070
    GO:0005509calcium ion binding IDA17215369
         
    Find genes that share ontologies with SRI           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SRI:
     Synthetic lethal with imatinib 

    Animal Models:
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    miRTarBase miRNAs that target SRI:
    hsa-mir-1 (MIRT023807)

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    Selected qRT-PCR Assays for microRNAs that regulate SRI (see all 24):
    hsa-miR-549 hsa-miR-3910 hsa-miR-548j hsa-miR-548i hsa-miR-522 hsa-miR-421 hsa-miR-3658 hsa-miR-1323
    SwitchGear 3'UTR luciferase reporter plasmidSRI 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SRI

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SORCN_HUMAN, P30626: Cytoplasm. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
    Note=Relocates to the sarcoplasmic reticulum membrane in response to elevated calcium levels
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    cytosol4
    plasma membrane4
    extracellular2
    cytoskeleton1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm TAS16130169
    GO:0005789endoplasmic reticulum membrane IDA10672515
    GO:0005829cytosol IDA10748169
    GO:0005886plasma membrane ----

    Find genes that share ontologies with SRI           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SRI About    
    See pathways by source

    SuperPathContained pathways About
    1Presenilin-Mediated Signaling
    Presenilin-Mediated Signaling

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SRI
        Presenilin-Mediated Signaling



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SRI
    Interactions:

        GeneGlobe Interaction Network for SRI

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for SRI (P306261, 2, 3 ENSP000002657294) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSEN2P498102, 3, ENSP000003557474MINT-17115 MINT-17116 I2D: score=4 STRING: ENSP00000355747
    SMAD2Q157962, 3MINT-61596 I2D: score=3 
    CALCOCO2Q131372, 3, ENSP000002589474MINT-67794 I2D: score=5 STRING: ENSP00000258947
    CACNA1CQ139363, ENSP000002663764I2D: score=3 STRING: ENSP00000266376
    CACNA1SQ136983, ENSP000003551924I2D: score=2 STRING: ENSP00000355192
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001508action potential TAS9668070
    GO:0006508proteolysis IBA--
    GO:0006810transport TAS9668070
    GO:0006816calcium ion transport IEA--
    GO:0006880intracellular sequestering of iron ion TAS9668070

    Find genes that share ontologies with SRI           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SRI (SORCN)

    1 HMDB Compound for SRI    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    5 Novoseek inferred chemical compound relationships for SRI gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ryanodine 70.3 9 10748169 (2), 9312152 (2), 12711611 (1), 12805242 (1) (see all 7)
    vincristine 56.6 10 18423116 (3), 8561500 (3), 16859119 (1), 18253933 (1) (see all 5)
    calcium 50.9 65 12824171 (5), 17579123 (4), 7873602 (3), 12711611 (3) (see all 23)
    doxorubicin 6.19 1 16213583 (1)
    lipid 0 3 11895795 (1), 17208471 (1), 12824171 (1)



    Find genes that share compounds with SRI           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SRI gene (4 alternative transcripts): 
    NM_001256891.1  NM_001256892.1  NM_003130.3  NM_198901.1  

    Unigene Cluster for SRI:

    Sorcin
    Hs.489040  [show with all ESTs]
    Unigene Representative Sequence: NM_003130
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265729(uc003ujq.1 uc011khg.1 uc003ujr.1) ENST00000419179
    ENST00000472930 ENST00000490437 ENST00000394641 ENST00000431660(uc011khh.1)
    ENST00000457606 ENST00000486860(uc010lej.1) ENST00000488015 ENST00000489079

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    Selected qRT-PCR Assays for microRNAs that regulate SRI (see all 24):
    hsa-miR-549 hsa-miR-3910 hsa-miR-548j hsa-miR-548i hsa-miR-522 hsa-miR-421 hsa-miR-3658 hsa-miR-1323
    SwitchGear 3'UTR luciferase reporter plasmidSRI 3' UTR sequence
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    Additional mRNA sequence: 

    AK129770.1 AK295225.1 AK296601.1 AK310366.1 AL117616.1 BC011025.1 L12387.1 M32886.1 

    15 DOTS entries:

    DT.317123  DT.100783754  DT.102829292  DT.121079224  DT.95174229  DT.97805280  DT.100783750  DT.100059371 
    DT.121079215  DT.121079243  DT.75161166  DT.92444381  DT.92444383  DT.95174235  DT.97855285 

    Selected AceView cDNA sequences (see all 386):

    CD678955 CD678920 AU123248 BM694346 BM782706 CR625185 AA455983 AI924107 
    BM702828 BM838473 CA431211 BM782710 AI368096 BQ575723 BE264327 CR610114 
    BQ774513 F08833 AW150391 AI418170 BU682085 CA418813 BQ711141 AW297715 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SRI (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b
    SP1:                                -     -     -                       -               
    SP2:                                -     -     -                                       
    SP3:                          -     -     -     -     -                 -               
    SP4:                                                                    -               
    SP5:        -                                                                           


    ECgene alternative splicing isoforms for SRI

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SRI expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGTAATCA
    SRI Expression
    About this image


    SRI expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neurons
             Mature Horizontal Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             Mature Horizontal Cells Inner Nuclear Layer
     
     Brain (Nervous System)
             Adult Dopaminergic Neurons Substantia Nigra pars Compacta
    SRI Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SRI Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.489040

    UniProtKB/Swiss-Prot: SORCN_HUMAN, P30626
    Tissue specificity: Detected in cardiac myocytes

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRI

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SRI gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sri1 , 5 sorcin1, 5 87.54(n)1
    95.96(a)1
      5 (3.38 cM)5
    1095521  NM_001080974.21  NP_001074443.11 
     80460785 
    chicken
    (Gallus gallus)
    Aves SRI1 sorcin 78.62(n)
    83.84(a)
      420538  NM_001080865.1  NP_001074334.1 
    lizard
    (Anolis carolinensis)
    Reptilia SRI6
    sorcin
    73(a)
    1 ↔ 1
    4(120008298-120022138)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.258242 Xenopus laevis transcribed sequence with moderate similarity more 78.79(n)    CA974605.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc640702 hypothetical protein MGC64070 73.81(n)   393344  BC053237.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG177656
    --
    33(a)
    1 → many
    2R(6367665-6369391)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PEF16
    Penta-EF-hand protein required for polar bud growt...
    13(a)
    1 → many
    VII(606136-607143) YGR058W


    ENSEMBL Gene Tree for SRI (if available)
    TreeFam Gene Tree for SRI (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SRI gene
    PEF12  PDCD62  GCA2  
    11 SIMAP similar genes for SRI using alignment to 6 protein entries:     SORCN_HUMAN (see all proteins):
    GCA    CAPN3    PDCD6    CAPN2    CAPNS2    CAPN1
    CAPNS1    CAPN8    CAPN11    CAPN9    PEF1

    Find genes that share paralogs with SRI           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for SRI
    PGOHUM00000245920 PGOHUM00000241436 PGOHUM00000233679


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SRI (see all 418)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1433206941,2
    C--87168180(+) GTTTT-/TTTG  
            
    TTTGT
    2 -- int10--------
    rs2007033611,2
    C--87168191(-) AAAAAA/CAAACA 2 -- int10--------
    rs1417184901,2
    --91141410(+) CCACAA/GCTGAT 2 -- ds5001 int10--------
    rs1471148311,2
    --91141447(+) TATGGC/TCCATA 2 -- ds5001 int10--------
    rs1876039881,2
    --91141460(+) CTTCAC/GCAAGG 2 -- ds5001 int10--------
    rs1477347801,2
    C--91141541(+) TGGTGA/GGTTGA 2 -- ds5001 int10--------
    rs1928547201,2
    --91141865(+) ATTAGC/TTGACA 2 -- ut310--------
    rs1848342831,2
    --91141960(+) TTTCAG/TTTTTT 2 -- ut310--------
    rs733976261,2
    C,F--91142093(+) CATATT/CATCTC 2 -- ut313Minor allele frequency- C:0.17WA CSA 122
    rs1883925201,2
    --91142213(+) CTTAAA/GATTTT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for SRI (87834432 - 87856308 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SRI: --
    Human Gene Mutation Database (HGMD): SRI
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SRI
    DNA2.0 Custom Variant and Variant Library Synthesis for SRI

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 182520    OMIM disorders: --


    Find genes that share disorders with SRI           About GenesLikeMe

    4 Novoseek inferred disease relationships for SRI gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 0 7 16213583 (4), 16934756 (3)
    tumors 0 5 11931848 (1), 12905789 (1), 20416286 (1), 16320026 (1)
    lymphoma 0 3 8561500 (2), 7873602 (1)
    heart failure 0 1 16118855 (1)

    Genetic Association Database (GAD): SRI
    Human Genome Epidemiology (HuGE) Navigator: SRI (46 documents)

    Export disorders for SRI gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SRI gene, integrated from 10 sources (see all 110):
    (articles sorted by number of sources associating them with SRI)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Purification, cDNA cloning, and expression of human sorcin in vincristine-resistant HOB1 lymphoma cell lines. (PubMed id 8561500)1, 2, 9 Lee W.P. (Arch. Biochem. Biophys. 1996)
    2. Isolation and molecular cloning of human sorcin a calcium-binding protein in vincristine-resistant HOB1 lymphoma cells. (PubMed id 7873602)1, 2, 9 Wang S.L.... Kao M.C. (Biochim. Biophys. Acta 1995)
    3. Crystal structure of calcium-free human sorcin: a member of the penta-EF-hand protein family. (PubMed id 11714909)1, 2, 9 Xie X.... Botfield M.C. (Protein Sci. 2001)
    4. The PEF family proteins sorcin and grancalcin interact in vivo and in vitro. (PubMed id 12804766)1, 2, 9 Hansen C.... Berchtold M.W. (FEBS Lett. 2003)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Molecular basis for the impaired function of the natural F112L sorcin mutant: X-ray crystal structure, calcium affinity, and interaction with annexin VII and the ryanodine receptor. (PubMed id 17699613)1, 2 Franceschini S.... Colotti G. (FASEB J. 2008)
    7. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1, 2 Oh J.H.... Kim N.S. (Mamm. Genome 2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. (PubMed id 1286667)1, 2 Rasmussen H.H....Vandekerckhove J. (Electrophoresis 1992)
    10. Genes amplified and overexpressed in human multidrug-resistant cell lines. (PubMed id 2901906)1, 3 Van der Bliek A.M....Borst P. (Cancer Res. 1988)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6717 HGNC: 11292 AceView: SRI Ensembl:ENSG00000075142 euGenes: HUgn6717
    ECgene: SRI H-InvDB: SRI

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SRI Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SRI gene:
    Search GeneIP for patents involving SRI

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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