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Aliases for SRI Gene

Aliases for SRI Gene

  • Sorcin 2 3
  • 22 KDa Protein 3 4
  • CP-22 3 4
  • CP22 3 4
  • SCN 3 6
  • V19 3 4
  • Calcium Binding Protein Amplified In Mutlidrug-Resistant Cells 3
  • H_RG167B05.1 3

External Ids for SRI Gene

Previous GeneCards Identifiers for SRI Gene

  • GC07M086370
  • GC07M087432
  • GC07M087447
  • GC07M087446
  • GC07M087479
  • GC07M087672
  • GC07M087834
  • GC07M082444

Summaries for SRI Gene

Entrez Gene Summary for SRI Gene

  • This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene. [provided by RefSeq, Mar 2012]

GeneCards Summary for SRI Gene

SRI (Sorcin) is a Protein Coding gene. Diseases associated with SRI include hereditary spherocytosis. Among its related pathways are Presenilin-Mediated Signaling. GO annotations related to this gene include calcium ion binding and receptor binding. An important paralog of this gene is PDCD6.

UniProtKB/Swiss-Prot for SRI Gene

  • Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels.

Gene Wiki entry for SRI Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRI Gene

Genomics for SRI Gene

Regulatory Elements for SRI Gene

Transcription factor binding sites by QIAGEN in the SRI gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SRI Gene

88,205,115 bp from pter
88,226,993 bp from pter
21,879 bases
Minus strand

Genomic View for SRI Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SRI Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRI Gene

Proteins for SRI Gene

  • Protein details for SRI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8MTH6
    • B4DKK2
    • D6W5Q0

    Protein attributes for SRI Gene

    198 amino acids
    Molecular mass:
    21676 Da
    Quaternary structure:
    • Homodimer. Interacts with GCA, RYR2 and ANXA7.
    • This protein has been shown to bind calcium with high affinity
    • This protein is encoded by an amplified gene in multidrug-resistant cells

    Three dimensional structures from OCA and Proteopedia for SRI Gene

    Alternative splice isoforms for SRI Gene


neXtProt entry for SRI Gene

Proteomics data for SRI Gene at MOPED

Post-translational modifications for SRI Gene

  • Ubiquitination at Lys127
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SRI Gene

Domains for SRI Gene

Gene Families for SRI Gene

  • EFHAND :EF-hand domain containing

Protein Domains for SRI Gene

Graphical View of Domain Structure for InterPro Entry



  • P30626
  • Contains 4 EF-hand domains.
genes like me logo Genes that share domains with SRI: view

Function for SRI Gene

Molecular function for SRI Gene

GENATLAS Biochemistry: sorcin,calcium binding protein (22kDa),overexpressed in multidrug resistant lines
UniProtKB/Swiss-Prot Function: Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels.

Gene Ontology (GO) - Molecular Function for SRI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 10748169
GO:0004198 calcium-dependent cysteine-type endopeptidase activity IBA --
GO:0005102 receptor binding TAS 9668070
GO:0005246 calcium channel regulator activity TAS 9668070
GO:0005509 calcium ion binding IDA 17215369
genes like me logo Genes that share ontologies with SRI: view

Phenotypes for SRI Gene

GenomeRNAi human phenotypes for SRI:
genes like me logo Genes that share phenotypes with SRI: view

Animal Model Products

miRNA for SRI Gene

miRTarBase miRNAs that target SRI

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SRI Gene

Localization for SRI Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRI Gene

Cytoplasm. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=Relocates to the sarcoplasmic reticulum membrane in response to elevated calcium levels.

Subcellular locations from

Jensen Localization Image for SRI Gene COMPARTMENTS Subcellular localization image for SRI gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 4
plasma membrane 4
extracellular 2
cytoskeleton 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SRI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm TAS 16130169
GO:0005739 mitochondrion IEA --
GO:0005789 endoplasmic reticulum membrane IDA 10672515
genes like me logo Genes that share ontologies with SRI: view

Pathways for SRI Gene

SuperPathways for SRI Gene

genes like me logo Genes that share pathways with SRI: view

Pathways by source for SRI Gene

1 Qiagen pathway for SRI Gene

Gene Ontology (GO) - Biological Process for SRI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001508 action potential TAS 9668070
GO:0006508 proteolysis IBA --
GO:0006810 transport TAS 9668070
GO:0006816 calcium ion transport IEA --
GO:0006880 intracellular sequestering of iron ion TAS 9668070
genes like me logo Genes that share ontologies with SRI: view

Compounds for SRI Gene

(1) HMDB Compounds for SRI Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca

(5) Novoseek inferred chemical compound relationships for SRI Gene

Compound -log(P) Hits PubMed IDs
ryanodine 70.3 9
vincristine 56.6 9
calcium 50.9 46
doxorubicin 6.19 1
lipid 0 3
genes like me logo Genes that share compounds with SRI: view

Transcripts for SRI Gene

Unigene Clusters for SRI Gene

Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SRI

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRI Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b
SP1: - - - -
SP2: - - -
SP3: - - - - - -
SP4: -
SP5: -

Relevant External Links for SRI Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SRI Gene

mRNA expression in normal human tissues for SRI Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SRI Gene

SOURCE GeneReport for Unigene cluster for SRI Gene Hs.489040

mRNA Expression by UniProt/SwissProt for SRI Gene

Tissue specificity: Detected in cardiac myocytes
genes like me logo Genes that share expressions with SRI: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SRI Gene

Orthologs for SRI Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SRI Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SRI 35
  • 99.83 (n)
  • 100 (a)
SRI 36
  • 100 (a)
(Bos Taurus)
Mammalia SRI 35
  • 94.84 (n)
  • 99.45 (a)
SRI 36
  • 98 (a)
(Canis familiaris)
Mammalia SRI 35
  • 93.6 (n)
  • 98.99 (a)
SRI 36
  • 85 (a)
(Mus musculus)
Mammalia Sri 35
  • 87.54 (n)
  • 95.96 (a)
Sri 16
Sri 36
  • 96 (a)
(Monodelphis domestica)
Mammalia SRI 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia SRI 36
  • 82 (a)
(Rattus norvegicus)
Mammalia Sri 35
  • 85.35 (n)
  • 91.92 (a)
(Gallus gallus)
Aves SRI 35
  • 78.62 (n)
  • 83.84 (a)
SRI 36
  • 83 (a)
(Anolis carolinensis)
Reptilia SRI 36
  • 73 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25824 35
tropical clawed frog
(Silurana tropicalis)
Amphibia sri 35
  • 73.73 (n)
  • 78.24 (a)
Str.6127 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9248 35
(Danio rerio)
Actinopterygii sri 35
  • 69.98 (n)
  • 77.48 (a)
sri 36
  • 73 (a)
zgc64070 35
fruit fly
(Drosophila melanogaster)
Insecta CG17765 36
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PEF1 36
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
Species with no ortholog for SRI:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SRI Gene

Gene Tree for SRI (if available)
Gene Tree for SRI (if available)

Paralogs for SRI Gene

Paralogs for SRI Gene

Selected SIMAP similar genes for SRI Gene using alignment to 6 proteins: Pseudogenes for SRI Gene

genes like me logo Genes that share paralogs with SRI: view

Variants for SRI Gene

Sequence variations from dbSNP and Humsavar for SRI Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs12074 -- 88,206,370(-) TCTCT(C/T)AACAG utr-variant-3-prime
rs13788 -- 88,210,046(-) TCAGT(C/T)TTGAC missense, reference
rs173850 -- 88,213,812(+) TTTCT(A/G)ATCTT intron-variant
rs734909 -- 88,206,798(+) ATATC(A/C)AAGAC intron-variant
rs1046192 -- 88,205,691(-) TGATA(C/T)ATCCA utr-variant-3-prime

Relevant External Links for SRI Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SRI Gene

Disorders for SRI Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SRI Gene including...

Search for SRI Gene in MalaCards »

(4) Novoseek inferred disease relationships for SRI Gene

Disease -log(P) Hits PubMed IDs
leukemia 0 7
tumors 0 4
lymphoma 0 3
heart failure 0 1

Relevant External Links for SRI

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SRI: view

No data available for UniProtKB/Swiss-Prot for SRI Gene

Publications for SRI Gene

  1. Isolation and molecular cloning of human sorcin a calcium-binding protein in vincristine-resistant HOB1 lymphoma cells. (PMID: 7873602) Wang S.L. … Kao M.C. (Biochim. Biophys. Acta 1995) 3 4 23
  2. Purification, cDNA cloning, and expression of human sorcin in vincristine-resistant HOB1 lymphoma cell lines. (PMID: 8561500) Lee W.P. (Arch. Biochem. Biophys. 1996) 3 4 23
  3. Crystal structure of calcium-free human sorcin: a member of the penta-EF-hand protein family. (PMID: 11714909) Xie X. … Botfield M.C. (Protein Sci. 2001) 3 4 23
  4. The PEF family proteins sorcin and grancalcin interact in vivo and in vitro. (PMID: 12804766) Hansen C. … Berchtold M.W. (FEBS Lett. 2003) 3 4 23
  5. Expression and clinical implication of soluble resistance-associated calcium-binding protein gene and multi-drug resistance gene in leukemia. (PMID: 12408767) Li G. … Zhao C. (Zhonghua Zhong Liu Za Zhi 2002) 3 23

Products for SRI Gene

Sources for SRI Gene

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