Aliases for SRI Gene
External Ids for SRI Gene
Previous GeneCards Identifiers for SRI Gene
This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene. [provided by RefSeq, Mar 2012]
GeneCards Summary for SRI Gene
SRI (Sorcin) is a Protein Coding gene. Diseases associated with SRI include Apical Myocardial Infarction and Interstitial Myocarditis. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Ion channel transport. GO annotations related to this gene include calcium ion binding and receptor binding. An important paralog of this gene is GCA.
UniProtKB/Swiss-Prot for SRI Gene
Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels.