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Aliases for SRGN Gene

Aliases for SRGN Gene

  • Serglycin 2 3
  • PRG1 3 4 6
  • PRG 3 4 6
  • Secretory Granule Proteoglycan Core Protein 3 4
  • Hematopoietic Proteoglycan Core Protein 3 4
  • Platelet Proteoglycan Core Protein 3 4
  • Proteoglycan 1, Secretory Granule 2 3
  • Serglycin Proteoglycan 2 3
  • P.PG 3 4
  • Proteoglycan Protein Core For Mast Cell Secretory Granule 3
  • Secretory Granule Proteoglycan Core Peptide 3
  • Hematopoetic Proteoglycan Core Peptide 3
  • Hematopoetic Proteoglycan Core Protein 3
  • PPG 3

External Ids for SRGN Gene

Previous Symbols for SRGN Gene

  • PRG
  • PRG1

Summaries for SRGN Gene

Entrez Gene Summary for SRGN Gene

  • This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for SRGN Gene

SRGN (Serglycin) is a Protein Coding gene. Diseases associated with SRGN include diffuse cutaneous mastocytosis and cutaneous mastocytosis. Among its related pathways are Hemostasis and Hemostasis. GO annotations related to this gene include collagen binding.

UniProtKB/Swiss-Prot for SRGN Gene

  • Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization.

Gene Wiki entry for SRGN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRGN Gene

Genomics for SRGN Gene

Genomic Location for SRGN Gene

Start:
69,088,072 bp from pter
End:
69,104,811 bp from pter
Size:
16,740 bases
Orientation:
Plus strand

Genomic View for SRGN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SRGN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRGN Gene

Regulatory Elements for SRGN Gene

Proteins for SRGN Gene

  • Protein details for SRGN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10124-SRGN_HUMAN
    Recommended name:
    Serglycin
    Protein Accession:
    P10124
    Secondary Accessions:
    • B2R4L7
    • Q5VW06

    Protein attributes for SRGN Gene

    Size:
    158 amino acids
    Molecular mass:
    17652 Da
    Quaternary structure:
    • Binds to activated CD44 and to GZMB

neXtProt entry for SRGN Gene

Proteomics data for SRGN Gene at MOPED

Post-translational modifications for SRGN Gene

  • O-glycosylated; contains chondroitin sulfate and heparan sulfate.
  • Glycosylation at Ser94, Ser96, Ser100, Ser102, Ser104, Ser106, Ser108, and Ser110

Other Protein References for SRGN Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SRGN Gene

Domains for SRGN Gene

Gene Families for SRGN Gene

HGNC:
  • ECMPG :Proteoglycans / Extracellular Matrix : Other

Protein Domains for SRGN Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

SRGN_HUMAN
Family:
  • Belongs to the serglycin family.:
    • P10124
genes like me logo Genes that share domains with SRGN: view

Function for SRGN Gene

Molecular function for SRGN Gene

UniProtKB/Swiss-Prot Function: Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization.
UniProtKB/Swiss-Prot Induction: By Epstein-Barr virus (EBV)

Gene Ontology (GO) - Molecular Function for SRGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11911826
GO:0005518 collagen binding IEA --
genes like me logo Genes that share ontologies with SRGN: view

Phenotypes for SRGN Gene

genes like me logo Genes that share phenotypes with SRGN: view

Animal Models for SRGN Gene

MGI Knock Outs for SRGN:

miRNA for SRGN Gene

miRTarBase miRNAs that target SRGN

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SRGN Gene

Localization for SRGN Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRGN Gene

Cytoplasmic granule. Secreted, extracellular space. Golgi apparatus. Note=Found in mast cell granules and in cytoplasmic granules of cytolytic T lymphocytes from where it is secreted upon cell activation. Secreted constitutively by endothelial cells and macrophages. Located to Golgi apparatus during neutrophil differentiation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRGN Gene COMPARTMENTS Subcellular localization image for SRGN gene
Compartment Confidence
extracellular 5
golgi apparatus 5
lysosome 4
vacuole 4
plasma membrane 2
cytosol 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SRGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 11154222
GO:0005794 Golgi apparatus IDA 15136585
GO:0031093 platelet alpha granule lumen TAS --
genes like me logo Genes that share ontologies with SRGN: view

Pathways for SRGN Gene

genes like me logo Genes that share pathways with SRGN: view

Gene Ontology (GO) - Biological Process for SRGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0007596 blood coagulation TAS --
GO:0008626 granzyme-mediated apoptotic signaling pathway IDA 11911826
GO:0016485 protein processing ISS --
GO:0030168 platelet activation TAS --
genes like me logo Genes that share ontologies with SRGN: view

Compounds for SRGN Gene

(8) Novoseek inferred chemical compound relationships for SRGN Gene

Compound -log(P) Hits PubMed IDs
chondroitin sulfate 75.4 7
glycosaminoglycan 72 3
heparan sulfate 58.1 3
mannose 6-phosphate 43.8 1
tunicamycin 42 1
genes like me logo Genes that share compounds with SRGN: view

Transcripts for SRGN Gene

mRNA/cDNA for SRGN Gene

Unigene Clusters for SRGN Gene

Serglycin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SRGN Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
SP1: - -
SP2: -
SP3: - - -
SP4:
SP5: -

Relevant External Links for SRGN Gene

GeneLoc Exon Structure for
SRGN
ECgene alternative splicing isoforms for
SRGN

Expression for SRGN Gene

mRNA expression in normal human tissues for SRGN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SRGN Gene

This gene is overexpressed in Whole Blood (25.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SRGN Gene

SOURCE GeneReport for Unigene cluster for SRGN Gene Hs.1908

genes like me logo Genes that share expressions with SRGN: view

Orthologs for SRGN Gene

This gene was present in the common ancestor of chordates.

Orthologs for SRGN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRGN 36
  • 96.41 (n)
  • 96.84 (a)
SRGN 37
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SRGN 36
  • 76.22 (n)
  • 62 (a)
SRGN 37
  • 61 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRGN 36
  • 78.34 (n)
  • 70.7 (a)
SRGN 37
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srgn 16
Srgn 37
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRGN 37
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves SRGN 37
  • 31 (a)
OneToOne
Species with no ortholog for SRGN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SRGN Gene

ENSEMBL:
Gene Tree for SRGN (if available)
TreeFam:
Gene Tree for SRGN (if available)

Paralogs for SRGN Gene

Pseudogenes.org Pseudogenes for SRGN Gene

genes like me logo Genes that share paralogs with SRGN: view

No data available for Paralogs for SRGN Gene

Variants for SRGN Gene

Sequence variations from dbSNP and Humsavar for SRGN Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs4892 -- 69,103,943(+) GGCTC(C/T)GGCTC reference, synonymous-codon, nc-transcript-variant
rs7377 -- 69,104,641(+) TAGTG(G/T)ATGTG utr-variant-3-prime, nc-transcript-variant
rs11182 -- 69,104,661(-) CAATC(A/T)TACTT utr-variant-3-prime, nc-transcript-variant
rs12301 -- 69,104,479(+) AGACT(C/T)TGACT utr-variant-3-prime, nc-transcript-variant
rs12437 -- 69,104,309(+) TCTAT(C/T)TTATT utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for SRGN Gene

Variant ID Type Subtype PubMed ID
nsv7010 CNV Loss 18451855

Relevant External Links for SRGN Gene

HapMap Linkage Disequilibrium report
SRGN

Disorders for SRGN Gene

(1) University of Copenhagen DISEASES for SRGN Gene

(1) Novoseek inferred disease relationships for SRGN Gene

Disease -log(P) Hits PubMed IDs
tumors 0 2
genes like me logo Genes that share disorders with SRGN: view

No data available for UniProtKB/Swiss-Prot for SRGN Gene

Publications for SRGN Gene

  1. The human serglycin gene. Nucleotide sequence and methylation pattern in human promyelocytic leukemia HL-60 cells and T-lymphoblast Molt-4 cells. (PMID: 1377686) Humphries D.E. … Stevens R.L. (J. Biol. Chem. 1992) 3 4 23
  2. Synthesis, secretion, and subcellular localization of serglycin proteoglycan in human endothelial cells. (PMID: 11154222) Schick B.P. … San Antonio J.D. (Blood 2001) 3 4 23
  3. Cytotoxic cell granule-mediated apoptosis. Characterization of the macromolecular complex of granzyme B with serglycin. (PMID: 12388539) Raja S.M. … Froelich C.J. (J. Biol. Chem. 2002) 3 4 23
  4. Localization of serglycin in human neutrophil granulocytes and their precursors. (PMID: 15136585) Niemann C.U. … Borregaard N. (J. Leukoc. Biol. 2004) 3 4 23
  5. Serglycin constitutively secreted by myeloma plasma cells is a potent inhibitor of bone mineralization in vitro. (PMID: 16870619) Theocharis A.D. … Hjerpe A. (J. Biol. Chem. 2006) 3 4 23

Products for SRGN Gene

Sources for SRGN Gene

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