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Aliases for SRGN Gene

Aliases for SRGN Gene

  • Serglycin 2 3 5
  • Secretory Granule Proteoglycan Core Protein 3 4
  • Hematopoietic Proteoglycan Core Protein 3 4
  • Platelet Proteoglycan Core Protein 3 4
  • Proteoglycan 1, Secretory Granule 2 3
  • Serglycin Proteoglycan 2 3
  • PRG1 3 4
  • P.PG 3 4
  • PRG 3 4
  • Proteoglycan Protein Core For Mast Cell Secretory Granule 3
  • Secretory Granule Proteoglycan Core Peptide 3
  • Hematopoetic Proteoglycan Core Peptide 3
  • Hematopoetic Proteoglycan Core Protein 3
  • PPG 3

External Ids for SRGN Gene

Previous HGNC Symbols for SRGN Gene

  • PRG
  • PRG1

Previous GeneCards Identifiers for SRGN Gene

  • GC10P070518
  • GC10P070847
  • GC10P064847

Summaries for SRGN Gene

Entrez Gene Summary for SRGN Gene

  • This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for SRGN Gene

SRGN (Serglycin) is a Protein Coding gene. Diseases associated with SRGN include diffuse cutaneous mastocytosis and megakaryocytic tumor. Among its related pathways are Platelet activation, signaling and aggregation. GO annotations related to this gene include collagen binding.

UniProtKB/Swiss-Prot for SRGN Gene

  • Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization.

Gene Wiki entry for SRGN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRGN Gene

Genomics for SRGN Gene

Regulatory Elements for SRGN Gene

Promoters for SRGN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SRGN on UCSC Golden Path with GeneCards custom track

Genomic Location for SRGN Gene

Chromosome:
10
Start:
69,088,072 bp from pter
End:
69,104,811 bp from pter
Size:
16,740 bases
Orientation:
Plus strand

Genomic View for SRGN Gene

Genes around SRGN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRGN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRGN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRGN Gene

Proteins for SRGN Gene

  • Protein details for SRGN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10124-SRGN_HUMAN
    Recommended name:
    Serglycin
    Protein Accession:
    P10124
    Secondary Accessions:
    • B2R4L7
    • Q5VW06

    Protein attributes for SRGN Gene

    Size:
    158 amino acids
    Molecular mass:
    17652 Da
    Quaternary structure:
    • Binds to activated CD44 and to GZMB.

neXtProt entry for SRGN Gene

Proteomics data for SRGN Gene at MOPED

Post-translational modifications for SRGN Gene

  • O-glycosylated; contains chondroitin sulfate and heparan sulfate.
  • Glycosylation at Ser 94, Ser 96, Ser 100, Ser 102, Ser 104, Ser 106, Ser 108, and Ser 110

Other Protein References for SRGN Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SRGN Gene

Domains & Families for SRGN Gene

Gene Families for SRGN Gene

Protein Domains for SRGN Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SRGN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P10124

UniProtKB/Swiss-Prot:

SRGN_HUMAN :
  • Belongs to the serglycin family.
Family:
  • Belongs to the serglycin family.
genes like me logo Genes that share domains with SRGN: view

Function for SRGN Gene

Molecular function for SRGN Gene

UniProtKB/Swiss-Prot Function:
Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization.
UniProtKB/Swiss-Prot Induction:
By Epstein-Barr virus (EBV).
genes like me logo Genes that share phenotypes with SRGN: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SRGN Gene

Localization for SRGN Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRGN Gene

Cytoplasmic granule. Secreted, extracellular space. Golgi apparatus. Note=Found in mast cell granules and in cytoplasmic granules of cytolytic T lymphocytes from where it is secreted upon cell activation (By similarity). Secreted constitutively by endothelial cells and macrophages (PubMed:11154222). Located to Golgi apparatus during neutrophil differentiation (PubMed:15136585). {ECO:0000250 UniProtKB:P13609, ECO:0000269 PubMed:11154222, ECO:0000269 PubMed:15136585}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRGN Gene COMPARTMENTS Subcellular localization image for SRGN gene
Compartment Confidence
extracellular 5
golgi apparatus 5
lysosome 5
vacuole 5
plasma membrane 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SRGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005615 extracellular space IDA 11154222
genes like me logo Genes that share ontologies with SRGN: view

Pathways & Interactions for SRGN Gene

genes like me logo Genes that share pathways with SRGN: view

Gene Ontology (GO) - Biological Process for SRGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008626 granzyme-mediated apoptotic signaling pathway IDA 11911826
GO:0016485 protein processing IEA,ISS --
GO:0030168 platelet activation TAS --
GO:0031214 biomineral tissue development IEA --
GO:0033368 protease localization to mast cell secretory granule IBA --
genes like me logo Genes that share ontologies with SRGN: view

No data available for SIGNOR curated interactions for SRGN Gene

Drugs & Compounds for SRGN Gene

(1) Drugs for SRGN Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(7) Additional Compounds for SRGN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SRGN: view

Transcripts for SRGN Gene

mRNA/cDNA for SRGN Gene

Unigene Clusters for SRGN Gene

Serglycin:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRGN Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
SP1: - -
SP2: -
SP3: - - -
SP4:
SP5: -

Relevant External Links for SRGN Gene

GeneLoc Exon Structure for
SRGN
ECgene alternative splicing isoforms for
SRGN

Expression for SRGN Gene

mRNA expression in normal human tissues for SRGN Gene

mRNA differential expression in normal tissues according to GTEx for SRGN Gene

This gene is overexpressed in Whole Blood (x25.9).

Protein differential expression in normal tissues from HIPED for SRGN Gene

This gene is overexpressed in Serum (41.3), Peripheral blood mononuclear cells (13.8), and Platelet (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SRGN Gene



SOURCE GeneReport for Unigene cluster for SRGN Gene Hs.1908

genes like me logo Genes that share expression patterns with SRGN: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SRGN Gene

Orthologs for SRGN Gene

This gene was present in the common ancestor of chordates.

Orthologs for SRGN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SRGN 35
  • 76.22 (n)
  • 62 (a)
SRGN 36
  • 61 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRGN 35
  • 78.34 (n)
  • 70.7 (a)
SRGN 36
  • 68 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SRGN 35
  • 96.41 (n)
  • 96.84 (a)
SRGN 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srgn 36
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRGN 36
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves SRGN 36
  • 31 (a)
OneToOne
Species with no ortholog for SRGN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SRGN Gene

ENSEMBL:
Gene Tree for SRGN (if available)
TreeFam:
Gene Tree for SRGN (if available)

Paralogs for SRGN Gene

Pseudogenes.org Pseudogenes for SRGN Gene

genes like me logo Genes that share paralogs with SRGN: view

No data available for Paralogs for SRGN Gene

Variants for SRGN Gene

Sequence variations from dbSNP and Humsavar for SRGN Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_032761 -
rs4892 -- 69,103,943(+) GGCTC(C/G/T)GGCTC nc-transcript-variant, reference, synonymous-codon
rs7377 -- 69,104,641(+) TAGTG(G/T)ATGTG nc-transcript-variant, utr-variant-3-prime
rs11182 -- 69,104,661(-) CAATC(A/T)TACTT nc-transcript-variant, utr-variant-3-prime
rs12301 -- 69,104,479(+) AGACT(C/T)TGACT nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SRGN Gene

Variant ID Type Subtype PubMed ID
nsv7010 CNV Loss 18451855

Variation tolerance for SRGN Gene

Residual Variation Intolerance Score: 61.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.80; 33.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRGN Gene

HapMap Linkage Disequilibrium report
SRGN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRGN Gene

Disorders for SRGN Gene

MalaCards: The human disease database

(7) MalaCards diseases for SRGN Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
diffuse cutaneous mastocytosis
  • dcm
megakaryocytic tumor
  • megakaryocytic neoplasm
mucinoses
glossopharyngeal neuralgia
  • glossovasopharyngeal neuralgia
glossopharyngeal nerve disease
  • glossopharyngeal nerve diseases
- elite association - COSMIC cancer census association via MalaCards
Search SRGN in MalaCards View complete list of genes associated with diseases

Relevant External Links for SRGN

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRGN
genes like me logo Genes that share disorders with SRGN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SRGN Gene

Publications for SRGN Gene

  1. Localization of serglycin in human neutrophil granulocytes and their precursors. (PMID: 15136585) Niemann C.U. … Borregaard N. (J. Leukoc. Biol. 2004) 3 4 23 67
  2. Serglycin and secretion in human monocytes. (PMID: 17909965) Kolset S.O. … Zernichow L. (Glycoconj. J. 2008) 3 23
  3. Serglycin constitutively secreted by myeloma plasma cells is a potent inhibitor of bone mineralization in vitro. (PMID: 16870619) Theocharis A.D. … Hjerpe A. (J. Biol. Chem. 2006) 3 23
  4. A novel mechanism for protein delivery: granzyme B undergoes electrostatic exchange from serglycin to target cells. (PMID: 15788411) Raja S.M. … Froelich C.J. (J. Biol. Chem. 2005) 3 23
  5. DNase I hypersensitivity patterns of the serglycin proteoglycan gene in resting and phorbol 12-myristate 13-acetate-stimulated human erythroleukemia (HEL), CHRF 288-11, and HL-60 cells compared with neutrophils and human umbilical vein endothelial cells. (PMID: 14506241) Castronuevo P. … Schick B.P. (J. Biol. Chem. 2003) 3 23

Products for SRGN Gene

Sources for SRGN Gene

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