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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SRGN Gene

protein-coding   GIFtS: 53
GCID: GC10P070847

serglycin

(Previous names: proteoglycan 1, secretory granule )
(Previous symbols: PRG, PRG1)
 Explore 15 diseases affiliated with
SRGN via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SRGN    

Aliases
for SRGN gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Serglycin1     Hematopoetic Proteoglycan Core Peptide2
PRG1 2 3 5     Hematopoetic Proteoglycan Core Protein2
PRG11 2 3 5     P.PG3
PPG1 2     Proteoglycan Protein Core For Mast Cell Secretory Granule2
Proteoglycan 1, Secretory Granule1 2     Secretory Granule Proteoglycan Core Peptide2
Hematopoietic Proteoglycan Core Protein2 3     Serglycin Proteoglycan2
Platelet Proteoglycan Core Protein2 3     P.PG3
Secretory Granule Proteoglycan Core Protein2 3     

External Ids:    HGNC: 93611   Entrez Gene: 55522   Ensembl: ENSG000001228627   OMIM: 1770405   UniProtKB: P101243   
ORGUL members:         
NONCODE:n410003    

Export aliases for SRGN gene to outside databases

Previous GC identifers: GC10P070518 GC10P064847


Summaries
for SRGN gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SRGN:
This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the
secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important
for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex
of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only
one of them protein-coding, have been found for this gene. (provided by RefSeq, Jul 2010)

UniProtKB/Swiss-Prot: SRGN_HUMAN, P10124
Function: Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in
secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for
storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of
neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a
complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of
TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization

Gene Wiki entry for SRGN


Genomic Views
for SRGN gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SRGN gene promoter:
         TBP   STAT1   HNF-3beta   c-Ets-1   FAC1   E2F-1   CP2   E2F   TFIID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): SRGN promoter sequence
   Search SABiosciences Chromatin IP Primers for SRGN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRGN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22.1   Ensembl cytogenetic band:  10q22.1   HGNC cytogenetic band: 10q22.1

SRGN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRGN gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P070847:  view genomic region     (about GC identifiers)

Start:
 70,847,828 bp from pter      End:
 70,864,567 bp from pter
Size:
 16,740 bases      Orientation:
 plus strand

Proteins
for SRGN gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SRGN_HUMAN, P10124 (See protein sequence)
Recommended Name: Serglycin precursor  
Size: 158 amino acids; 17652 Da
Subunit: Binds to activated CD44 and to GZMB
Subcellular location: Cytoplasmic granule (By similarity). Secreted, extracellular space. Golgi apparatus. Note=Found
in mast cell granules and in cytoplasmic granules of cytolytic T lymphocytes from where it is secreted upon cell
activation. Secreted constitutively by endothelial cells and macrophages. Located to Golgi apparatus during neutrophil
differentiation
Secondary accessions: B2R4L7 Q5VW06

Explore the universe of human proteins at neXtProt for SRGN: NX_P10124

Post-translational modifications:

  • O-glycosylated; contains chondroitin sulfate and heparan sulfate (By similarity)1
  • View neXtProt modification sites for NX_P10124

    • SRGN Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002718.2  
    ENSEMBL proteins: 
     ENSP00000242465  
    Reactome Protein details: P10124
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: SRGN
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    Novus Biologicals SRGN Proteins
    Novus Biologicals SRGN Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for SRGN
    Uscn Proteins for SRGN

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane ----
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA11154222
    GO:0005794Golgi apparatus IDA15136585
    GO:0031093platelet alpha granule lumen TAS--


    SRGN for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for SRGN gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SRGN for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007455 Serglycin

    Graphical View of Domain Structure for InterPro Entry P10124

    ProtoNet protein and cluster: P10124

    1 Blocks protein family: IPB007455 Serglycin

    UniProtKB/Swiss-Prot: SRGN_HUMAN, P10124
    Similarity: Belongs to the serglycin family


    Function
    for SRGN gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SRGN_HUMAN, P10124
    Function: Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in
    secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for
    storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of
    neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a
    complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of
    TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization
    Induction: By Epstein-Barr virus (EBV)

    miRNA
    Products:            		 OriGene 3'-UTR Clone: SRGN
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SRGN
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate SRGN:
    hsa-miR-3671 hsa-miR-9 hsa-miR-3143
    SwitchGear 3'UTR luciferase reporter plasmid: SRGN 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SRGN (see all 7)
    OriGene shRNA RFP: SRGN
    OriGene siRNA: SRGN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRGN

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SRGN

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRGN (see all 3)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRGN 

    Cell Line
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    Search LifeMap BioReagents cell lines for SRGN

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11911826
    GO:0005518collagen binding IEA--


    SRGN for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Srgntm1Mabr for SRGN
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Srgn):
     hematopoietic system  immune system 

    SRGN for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SRGN gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Platelet degranulation
    		Platelet degranulation 1.00
    		Response to elevated platelet cytosolic Ca2+0.94
    2Platelet activation, signaling and aggregation
    		Platelet activation, signaling and aggregation1.00
    		Hemostasis0.43

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for SRGN
        Hemostasis
    Platelet degranulation
    Platelet activation, signaling and aggregation
    Response to elevated platelet cytosolic Ca2+



    SRGN for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SRGN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/44 Interacting proteins for SRGN (P101241, 2, 3 ENSP000002424654) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSRC1Q6PGN92, 3, ENSP000003589254MINT-8272186 I2D: score=2 STRING: ENSP00000358925
    UBR4Q5T4S72, 3, ENSP000003644034MINT-8272197 I2D: score=2 STRING: ENSP00000364403
    CEP70Q8NHQ12, 3MINT-8272175 I2D: score=2 
    CRELD2Q6UXH12, 3MINT-8272164 I2D: score=1 
    GZMBP101441, 3, ENSP000002163414EBI-744915,EBI-2505785 I2D: score=4 STRING: ENSP00000216341
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002576platelet degranulation TAS--
    GO:0006915apoptotic process IDA11911826
    GO:0007596blood coagulation TAS--
    GO:0016485protein processing ISS--
    GO:0030168platelet activation TAS--


    SRGN for ontologies           About GeneDecksing



    Drugs & Compounds
    for SRGN gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SRGN for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SRGN
    8 Novoseek chemical compound relationships for SRGN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chondroitin sulfate 75.4 8 12960244 (2), 9231152 (1), 19915053 (1), 16107729 (1) (see all 6)
    glycosaminoglycan 72 3 7559813 (1), 9334256 (1), 16870619 (1)
    heparan sulfate 58.1 3 9231152 (1), 9334256 (1), 8613703 (1)
    mannose 6-phosphate 43.8 1 17210618 (1)
    tunicamycin 42 2 17210618 (1)
    heparin 36.4 3 9334256 (1), 19915053 (1), 8613703 (1)
    dmso 27.9 1 7559813 (1)
    sulfate 14.5 1 8613703 (1)

    Search CenterWatch for drugs/clinical trials and news about SRGN 

    Transcripts
    for SRGN gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SRGN gene: 
    NM_002727.2  

    Unigene Cluster for SRGN:

    Serglycin
    Hs.1908  [show with all ESTs]
    Unigene Representative Sequence: CD359027
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000462445 ENST00000242465(uc001joz.3 uc021prx.1)

    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate SRGN:
    hsa-miR-3671 hsa-miR-9 hsa-miR-3143
    SwitchGear 3'UTR luciferase reporter plasmid: SRGN 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SRGN (see all 7)
    OriGene shRNA RFP: SRGN
    OriGene siRNA: SRGN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRGN
    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRGN

    Additional cDNA sequence: 

    AK311873.1 BC015516.1 J03223.1 NR_036430.1 X12765.1 X17042.1 

    17 DOTS entries:

    DT.318163  DT.100876610  DT.100876613  DT.100876611  DT.100876605  DT.91775980  DT.100876609  DT.40275425 
    DT.95158633  DT.121226519  DT.121226510  DT.100876603  DT.91775979  DT.91775983  DT.91885366  DT.95158632 
    DT.95158638 

    24/628 AceView cDNA sequences (see all 628):

    AI383440 CD368339 CR612769 AI167743 NM_002727 BI966851 AA278759 AA321395 
    BF899566 CR609954 CR626802 BG057351 AI472710 AA357921 BP337908 AI093438 
    BF222267 CR626092 AW613439 CR603277 T28022 CR610350 AW075770 CR616782 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SRGN    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
    SP1:              -           -                     
    SP2:                          -                     
    SP3:              -     -     -                     
    SP4:                                                
    SP5:              -                                 


    ECgene alternative splicing isoforms for SRGN

    Expression
    for SRGN gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SRGN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCCATAAAAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SRGN expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Extraembryonic MesodermExtraembryonic Capillary PlexusExtraembryonic AngioblastsEndothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 7 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
    PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)Lateral Plate Mesoderm, Neural Crest
    PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor EN27 (Embryonic Progenitor Cell)
    Adult human kidney epithelial cells (Primary Cell)Kidney
    Extraembryonic endoderm-like cells (Generation of extrae...)

    See SRGN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SRGN

    SOURCE GeneReport for Unigene cluster: Hs.1908
        SABiosciences Custom PCR Arrays for SRGN
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRGN

    Orthologs
    for SRGN gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for SRGN gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Srgn1 , 5 serglycin1, 5 63.47(n)1
    52.05(a)1    		   10 (32.42 cM)5
    190731  NM_011157.21  NP_035287.11 
     624938335 
    chicken
    (Gallus gallus)    		 Aves SRGN6
    		 Uncharacterized protein
    		 31(a)
    		 1 ↔ 1
    		 6(11913107-11918221)


    ENSEMBL Gene Tree for SRGN (if available)
    TreeFam Gene Tree for SRGN (if available) 

    Paralogs
    for SRGN gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SRGN gene

    SRGN for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SRGN
    PGOHUM00000248638


    Genomic Variants
    for SRGN gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/358 NCBI SNPs in SRGN are shown (see all 358)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs741377791,2
    		C,--70845933(+) GCTTGG/AAGACG 2 -- us2k12Minor allele frequency- A:0.04WA 120
    rs347901951,2
    		C,F,--70845938(+) GAGACG/ACCCCT 2 -- us2k16Minor allele frequency- A:0.11NA WA EA 364
    rs1167001411,2
    		F,--70846045(+) AGACTC/TTGTCC 2 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1439303481,2
    		--70846187(+) GGAGCA/GGTAGG 2 -- us2k10--------
    rs341795821,2
    		C,F,--70846258(+) GCCACA/GAGGGC 2 -- us2k15Minor allele frequency- G:0.29NA 128
    rs1458524651,2
    		--70846276(+) TATGAC/TAGGCT 2 -- us2k10--------
    rs1813769841,2
    		--70846303(+) CTTTAC/TTTTAT 2 -- us2k10--------
    rs352957351,2
    		C,F,--70846378(+) TGGCAC/TGATCT 2 -- us2k13Minor allele frequency- T:0.50NA 6
    rs28550231,2
    		C,F,--70846441(+) CTCCCG/AAGTAG 2 -- us2k12Minor allele frequency- A:0.50WA CSA 4
    rs1855825351,2
    		--70846774(+) ATTTCC/TGGCTT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SRGN (70847828 - 70864567 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SRGN: --

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    Disorders / Diseases
    for SRGN gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SRGN for disorders           About GeneDecksing

    OMIM gene information: 177040    OMIM disorders: --

    15 diseases for SRGN:    About MalaCards
    hemophagocytic lymphohistiocytosis    cleft palate    megakaryocytic tumor    acute myeloid leukemia
    intrahepatic cholangiocarcinoma    myeloid leukemia    mastocytosis    cholangiocarcinoma
    cholera    pertussis    nasopharyngitis    leukemia
    myeloma    ataxia    prostatitis

    1 disease from the University of Copenhagen DISEASES database for SRGN:
    Cholera

    1 Novoseek disease relationship for SRGN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 2 9334256 (1), 18066495 (1)


    Export disorders for SRGN gene to outside databases

    Publications
    for SRGN gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SRGN gene, integrated from 9 sources (see all 82):
    (articles sorted by number of sources associating them with SRGN)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Localization of serglycin in human neutrophil granulocytes and their precursors. (PubMed id 15136585)1, 2, 9 Niemann C.U....Borregaard N. (2004)
    2. Serglycin constitutively secreted by myeloma plasma cells is a potent inhibitor of bone mineralization in vitro. (PubMed id 16870619)1, 2, 9 Theocharis A.D....Hjerpe A. (2006)
    3. Synthesis, secretion, and subcellular localization of serglycin proteoglycan in human endothelial cells. (PubMed id 11154222)1, 2, 9 Schick B.P.... San Antonio J.D. (2001)
    4. Cytotoxic cell granule-mediated apoptosis. Characterization of the macromolecular complex of granzyme B with serglycin. (PubMed id 12388539)1, 2, 9 Raja S.M.... Froelich C.J. (2002)
    5. The human serglycin gene. Nucleotide sequence and methylation pattern in human promyelocytic leukemia HL-60 cells and T-lymphoblast Molt-4 cells. (PubMed id 1377686)1, 2, 9 Humphries D.E.... Stevens R.L. (1992)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation. (PubMed id 11911826)1, 2 Metkar S.S.... Froelich C.J. (2002)
    8. Characterization of the human gene that encodes the peptide core of secretory granule proteoglycans in promyelocytic leukemia HL-60 cells and analysis of the translated product. (PubMed id 2180935)1, 2 Nicodemus C.F....Stevens R.L. (1990)
    9. Nucleotide sequence of a cDNA encoding a hemopoietic proteoglycan core protein. (PubMed id 2798108)1, 2 Stellrecht C.M. and Saunders G.F. (1989)
    10. Complete amino acid sequence of a human platelet proteoglycan. (PubMed id 3402609)1, 2 Alliel P.M....Jolles P. (1988)

    External Searches for SRGN gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SRGN gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5552 HGNC: 9361 AceView: PRG1 Ensembl:ENSG00000122862 euGenes: HUgn5552
    ECgene: SRGN H-InvDB: SRGN

    Other Databases showing SRGN gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SRGN gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SRGN Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SRGN gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SRGN gene:
    Search GeneIP for patents involving SRGN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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