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SRGN Gene

protein-coding   GIFtS: 56
GCID: GC10P070847

Serglycin

(Previous names: proteoglycan 1, secretory granule)
(Previous symbols: PRG, PRG1)
  See SRGN-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
serglycin1 2     PPG2
PRG1 2 3 5     Hematopoetic Proteoglycan Core Peptide2
PRG11 2 3 5     Hematopoetic Proteoglycan Core Protein2
Proteoglycan 1, Secretory Granule1 2     p.PG2
Serglycin Proteoglycan1 2     Proteoglycan Protein Core For Mast Cell Secretory Granule2
Hematopoietic Proteoglycan Core Protein2 3     Secretory Granule Proteoglycan Core Peptide2
Platelet Proteoglycan Core Protein2 3     P.PG3
Secretory Granule Proteoglycan Core Protein2 3     

External Ids:    HGNC: 93611   Entrez Gene: 55522   Ensembl: ENSG000001228627   OMIM: 1770405   UniProtKB: P101243   
ORGUL members:         

Export aliases for SRGN gene to outside databases

Previous GC identifers: GC10P070518 GC10P064847


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SRGN Gene:
This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the
secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be
important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the
macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis.
Two transcript variants, only one of them protein-coding, have been found for this gene. (provided by RefSeq, Jul
2010)

GeneCards Summary for SRGN Gene:
SRGN (serglycin) is a protein-coding gene. Diseases associated with SRGN include diffuse cutaneous mastocytosis, and cutaneous mastocytosis. GO annotations related to this gene include collagen binding.

UniProtKB/Swiss-Prot: SRGN_HUMAN, P10124
Function: Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in
secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and
for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules
of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming
a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of
TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization

Gene Wiki entry for SRGN Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the SRGN gene promoter:
         TBP   STAT1   HNF-3beta   c-Ets-1   FAC1   E2F-1   CP2   E2F   TFIID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): SRGN promoter sequence
   Search Chromatin IP Primers for SRGN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SRGN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22.1   Ensembl cytogenetic band:  10q22.1   HGNC cytogenetic band: 10q22.1

SRGN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRGN gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P070847:  view genomic region     (about GC identifiers)

Start:
70,847,828 bp from pter      End:
70,864,567 bp from pter
Size:
16,740 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SRGN_HUMAN, P10124 (See protein sequence)
Recommended Name: Serglycin precursor  
Size: 158 amino acids; 17652 Da
Subunit: Binds to activated CD44 and to GZMB
Secondary accessions: B2R4L7 Q5VW06

Explore the universe of human proteins at neXtProt for SRGN: NX_P10124

Explore proteomics data for SRGN at MOPED

Post-translational modifications: 

  • O-glycosylated; contains chondroitin sulfate and heparan sulfate (By similarity)1
  • Glycosylation2 at Ser94, Ser96, Ser100, Ser102, Ser104, Ser106, Ser108, Ser110

  • See SRGN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002718.2  
    ENSEMBL proteins: 
     ENSP00000242465  
    Reactome Protein details: P10124

    SRGN Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for SRGN

     
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    antibodies-online proteins for SRGN (13 products) 

     
    antibodies-online peptides for SRGN

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    antibodies-online antibodies for SRGN (30 products) 

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    antibodies-online kits for SRGN (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ECMPG: Proteoglycans / Extracellular Matrix : Other

    1 InterPro protein domain:
     IPR007455 Serglycin

    Graphical View of Domain Structure for InterPro Entry P10124

    ProtoNet protein and cluster: P10124

    1 Blocks protein domain: IPB007455 Serglycin

    UniProtKB/Swiss-Prot: SRGN_HUMAN, P10124
    Similarity: Belongs to the serglycin family


    Find genes that share domains with SRGN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRGN_HUMAN, P10124
    Function: Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in
    secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and
    for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules
    of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming
    a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of
    TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization
    Induction: By Epstein-Barr virus (EBV)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11911826
    GO:0005518collagen binding IEA--
         
    Find genes that share ontologies with SRGN           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Srgn):
     hematopoietic system  immune system 

    Find genes that share phenotypes with SRGN           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Srgntm1Mabr for SRGN

       genOway: Develop your customized and physiologically relevant rodent model for SRGN

    miRNA
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    miRTarBase miRNAs that target SRGN:
    hsa-mir-26b-5p (MIRT028982)

    Block miRNA regulation of human, mouse, rat SRGN using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate SRGN:
    hsa-miR-3671 hsa-miR-9 hsa-miR-3143
    SwitchGear 3'UTR luciferase reporter plasmidSRGN 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SRGN

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    GenScript: all cDNA clones in your preferred vector: SRGN (NM_002727)
    Sino Biological Human cDNA Clone for SRGN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRGN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRGN

    Cell Line
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SRGN_HUMAN, P10124: Cytoplasmic granule (By similarity). Secreted, extracellular space. Golgi apparatus.
    Note=Found in mast cell granules and in cytoplasmic granules of cytolytic T lymphocytes from where it is secreted
    upon cell activation. Secreted constitutively by endothelial cells and macrophages. Located to Golgi apparatus
    during neutrophil differentiation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    golgi apparatus5
    lysosome4
    vacuole4
    plasma membrane2
    cytosol1
    endoplasmic reticulum1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA11154222
    GO:0005794Golgi apparatus IDA15136585
    GO:0031093platelet alpha granule lumen TAS--
    GO:0042588zymogen granule IEA--

    Find genes that share ontologies with SRGN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SRGN About    
    See pathways by source

    SuperPathContained pathways About
    1Response to elevated platelet cytosolic Ca2+
    Response to elevated platelet cytosolic Ca2+0.94
    Platelet degranulation0.94
    2Hemostasis
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43


    Find genes that share SuperPaths with SRGN           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for SRGN
        Platelet degranulation


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SRGN
    Interactions:

        GeneGlobe Interaction Network for SRGN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SRGN (P101241, 2, 3 ENSP000002424654) via UniProtKB, MINT, STRING, and/or I2D (see all 54)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSRC1Q6PGN92, 3, ENSP000003589254MINT-8272186 I2D: score=2 STRING: ENSP00000358925
    UBR4Q5T4S72, 3, ENSP000003644034MINT-8272197 I2D: score=2 STRING: ENSP00000364403
    CEP70Q8NHQ12, 3MINT-8272175 I2D: score=2 
    CRELD2Q6UXH12, 3MINT-8272164 I2D: score=1 
    BAG6P463793I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002576platelet degranulation TAS--
    GO:0007596blood coagulation TAS--
    GO:0008626granzyme-mediated apoptotic signaling pathway IDA11911826
    GO:0016485protein processing ISS--
    GO:0030168platelet activation TAS--

    Find genes that share ontologies with SRGN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SRGN

    8 Novoseek inferred chemical compound relationships for SRGN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chondroitin sulfate 75.4 8 12960244 (2), 9231152 (1), 19915053 (1), 16107729 (1) (see all 6)
    glycosaminoglycan 72 3 7559813 (1), 9334256 (1), 16870619 (1)
    heparan sulfate 58.1 3 9231152 (1), 9334256 (1), 8613703 (1)
    mannose 6-phosphate 43.8 1 17210618 (1)
    tunicamycin 42 2 17210618 (1)
    heparin 36.4 3 9334256 (1), 19915053 (1), 8613703 (1)
    dmso 27.9 1 7559813 (1)
    sulfate 14.5 1 8613703 (1)



    Find genes that share compounds with SRGN           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SRGN gene: 
    NM_002727.2  

    Unigene Cluster for SRGN:

    Serglycin
    Hs.1908  [show with all ESTs]
    Unigene Representative Sequence: CD359027
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000462445 ENST00000242465(uc001joz.3 uc021prx.1)
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidSRGN 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SRGN
      QuantiTect SYBR Green Assays in human, mouse, rat SRGN
      QuantiFast Probe-based Assays in human, mouse, rat SRGN

    Additional mRNA sequence: 

    AK311873.1 BC015516.1 J03223.1 NR_036430.1 X12765.1 X17042.1 

    15 DOTS entries:

    DT.318163  DT.100876610  DT.100876613  DT.100876611  DT.100876605  DT.91775980  DT.100876609  DT.40275425 
    DT.95158633  DT.121226519  DT.100876603  DT.91775979  DT.91885366  DT.95158638  DT.121226510 

    Selected AceView cDNA sequences (see all 628):

    AW075770 AI167743 NM_002727 CR609954 CR616782 BI966851 BF899566 CR603277 
    BF222267 CR612769 CR626092 BG057351 T28022 AA357921 CR610350 AW613439 
    CR626802 CD368339 AI383440 BP337908 AA321395 AI472710 AI093438 AA278759 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SRGN    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
    SP1:              -           -                     
    SP2:                          -                     
    SP3:              -     -     -                     
    SP4:                                                
    SP5:              -                                 


    ECgene alternative splicing isoforms for SRGN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SRGN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCATAAAAT
    SRGN Expression
    About this image


    SRGN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 26) fully expand
     
     Fibroblasts
             Cardiac Fibroblasts Myocardium
             Detroit 551
     
     Epithelial Cells
             Fetal Matrix Cells Hair Follicle
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
     
     NULL (Uncategorized)
             CD31, CD144 positive cells
    SRGN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SRGN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.1908
        Custom PCR Arrays for SRGN
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRGN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SRGN gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srgn5 serglycin   --   10 (32.42 cM) 62493833 
    chicken
    (Gallus gallus)
    Aves SRGN6
    serglycin
    31(a)
    1 ↔ 1
    6(10403302-10408400)


    ENSEMBL Gene Tree for SRGN (if available)
    TreeFam Gene Tree for SRGN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SRGN gene

    Find genes that share paralogs with SRGN           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SRGN
    PGOHUM00000248638


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SRGN (see all 430)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs741377791,2
    C--70845933(+) GCTTGG/AAGACG 2 -- us2k12Minor allele frequency- A:0.04WA 120
    rs347901951,2
    C,F--70845938(+) GAGACG/ACCCCT 2 -- us2k16Minor allele frequency- A:0.11NA WA EA 364
    rs1167001411,2
    F--70846045(+) AGACTC/TTGTCC 2 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1439303481,2
    C--70846187(+) GGAGCA/GGTAGG 2 -- us2k10--------
    rs341795821,2
    C,F--70846258(+) GCCACA/GAGGGC 2 -- us2k15Minor allele frequency- G:0.29NA 128
    rs1458524651,2
    --70846276(+) TATGAC/TAGGCT 2 -- us2k10--------
    rs1813769841,2
    --70846303(+) CTTTAC/TTTTAT 2 -- us2k10--------
    rs352957351,2
    C,F--70846378(+) TGGCAC/TGATCT 2 -- us2k13Minor allele frequency- T:0.50NA 6
    rs28550231,2
    C,F--70846441(+) CTCCCG/AAGTAG 2 -- us2k12Minor allele frequency- A:0.50WA CSA 4
    rs1855825351,2
    --70846774(+) ATTTCC/TGGCTT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SRGN (70847828 - 70864567 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SRGN:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7010CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SRGN
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 177040    OMIM disorders: --

    2 diseases for SRGN:    
    About MalaCards
    diffuse cutaneous mastocytosis    cutaneous mastocytosis

    1 disease from the University of Copenhagen DISEASES database for SRGN:
    Cholera

    Find genes that share disorders with SRGN           About GenesLikeMe

    1 Novoseek inferred disease relationship for SRGN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 2 9334256 (1), 18066495 (1)


    Export disorders for SRGN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SRGN gene, integrated from 10 sources (see all 86):
    (articles sorted by number of sources associating them with SRGN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Localization of serglycin in human neutrophil granulocytes and their precursors. (PubMed id 15136585)1, 2, 9 Niemann C.U....Borregaard N. (J. Leukoc. Biol. 2004)
    2. Serglycin constitutively secreted by myeloma plasma cells is a potent inhibitor of bone mineralization in vitro. (PubMed id 16870619)1, 2, 9 Theocharis A.D....Hjerpe A. (J. Biol. Chem. 2006)
    3. Synthesis, secretion, and subcellular localization of serglycin proteoglycan in human endothelial cells. (PubMed id 11154222)1, 2, 9 Schick B.P.... San Antonio J.D. (Blood 2001)
    4. Cytotoxic cell granule-mediated apoptosis. Characterization of the macromolecular complex of granzyme B with serglycin. (PubMed id 12388539)1, 2, 9 Raja S.M.... Froelich C.J. (J. Biol. Chem. 2002)
    5. The human serglycin gene. Nucleotide sequence and methylation pattern in human promyelocytic leukemia HL-60 cells and T-lymphoblast Molt-4 cells. (PubMed id 1377686)1, 2, 9 Humphries D.E.... Stevens R.L. (J. Biol. Chem. 1992)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation. (PubMed id 11911826)1, 2 Metkar S.S.... Froelich C.J. (Immunity 2002)
    8. Characterization of the human gene that encodes the peptide core of secretory granule proteoglycans in promyelocytic leukemia HL-60 cells and analysis of the translated product. (PubMed id 2180935)1, 2 Nicodemus C.F....Stevens R.L. (J. Biol. Chem. 1990)
    9. Nucleotide sequence of a cDNA encoding a hemopoietic proteoglycan core protein. (PubMed id 2798108)1, 2 Stellrecht C.M. and Saunders G.F. (Nucleic Acids Res. 1989)
    10. Complete amino acid sequence of a human platelet proteoglycan. (PubMed id 3402609)1, 2 Alliel P.M....Jolles P. (FEBS Lett. 1988)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5552 HGNC: 9361 AceView: PRG1 Ensembl:ENSG00000122862 euGenes: HUgn5552
    ECgene: SRGN H-InvDB: SRGN

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SRGN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SRGN gene:
    Search GeneIP for patents involving SRGN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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