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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SRGAP3 Gene

protein-coding   GIFtS: 64
GCID: GC03M008998

SLIT-ROBO Rho GTPase Activating Protein 3

(Previous name: SLIT-ROBO Rho GTPase activating protein 2)
(Previous symbol: SRGAP2)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SLIT-ROBO Rho GTPase Activating Protein 31 2     WRP2 3
SRGAP21 2 3     KIAA04113 5
MEGAP2 3 5     SLIT-ROBO Rho GTPase-Activating Protein 32
SLIT-ROBO Rho GTPase Activating Protein 21 2     WAVE-Associated Rac GTPase Activating Protein2
Mental Disorder-Associated GAP2 3     KIAA11563
Rho GTPase-Activating Protein 142 3     srGAP33
ARHGAP142 3     WAVE-Associated Rac GTPase-Activating Protein3

External Ids:    HGNC: 197441   Entrez Gene: 99012   Ensembl: ENSG000001962207   OMIM: 6065255   UniProtKB: O432953   

Export aliases for SRGAP3 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SRGAP3 Gene: 
SRGAP3 (SLIT-ROBO Rho GTPase activating protein 3) is a protein-coding gene. Diseases associated with SRGAP3 include mental disorders, and atrioventricular septal defect, and among its related super-pathways are Inactivation of Cdc42 and Rac and Axon guidance. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP17.

UniProtKB/Swiss-Prot: SRGP3_HUMAN, O43295
Function: GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1
signaling in neurons

Gene Wiki entry for SRGAP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SRGAP3 gene promoter:
         HEN1   TBP   S8   p53   SEF-1 (1)   ITF-2   Tal-1beta   E47   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSRGAP3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SRGAP3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRGAP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.3   Ensembl cytogenetic band:  3p25.3   HGNC cytogenetic band: 3p25.3

SRGAP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRGAP3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M008998:  view genomic region     (about GC identifiers)

Start:
9,022,275 bp from pter      End:
9,404,737 bp from pter
Size:
382,463 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SRGP3_HUMAN, O43295 (See protein sequence)
Recommended Name: SLIT-ROBO Rho GTPase-activating protein 3  
Size: 1099 amino acids; 124504 Da
Subunit: Homodimer (Probable). Forms a heterooligomer with SRGAP1 and SRGAP2 through its F-BAR domain. Interacts
with WASF1. Probably interacts with ROBO1. Interacts with FASLG
Secondary accessions: Q8IX13 Q8IZV8
Alternative splicing: 3 isoforms:  O43295-1   O43295-2   O43295-3   

Explore the universe of human proteins at neXtProt for SRGAP3: NX_O43295

Explore proteomics data for SRGAP3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43295

  • SRGAP3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SRGAP3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001028289.1  NP_055665.1  

    ENSEMBL proteins: 
     ENSP00000373347   ENSP00000353587  
    Reactome Protein details: O43295
    Human Recombinant Protein Products for SRGAP3: 
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    Cloud-Clone Corp. Proteins for SRGAP3 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--

    SRGAP3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ARHGAP: Rho GTPase activating proteins

    4 InterPro protein domains:
     IPR001060 FCH_dom
     IPR008936 Rho_GTPase_activation_prot
     IPR001452 SH3_domain
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry O43295

    ProtoNet protein and cluster: O43295

    4 Blocks protein domains:
    IPB000198 RhoGAP domain
    IPB001060 Cdc15/Fes/CIP4
    IPB001452 SH3 domain signature
    IPB002017 Spectrin repeat


    UniProtKB/Swiss-Prot: SRGP3_HUMAN, O43295
    Domain: The F-BAR domain mediates oligomerization, binds membranes, and induces plasma membrane protrusions
    Similarity: Contains 1 FCH domain
    Similarity: Contains 1 Rho-GAP domain
    Similarity: Contains 1 SH3 domain


    SRGAP3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRGP3_HUMAN, O43295
    Function: GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1
    signaling in neurons

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IEA--
    GO:0005515protein binding ----
         
    SRGAP3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SRGAP3:
     Increased G1 DNA content 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Srgap3):
     behavior/neurological  homeostasis/metabolism  mortality/aging  nervous system 

    SRGAP3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SRGAP3: Srgap3tm1.1Zi Srgap3tm1.1Ssod

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SRGAP3 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SRGAP3 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Developmental Biology
    Developmental Biology0.56
    Axon guidance0.56
    Signaling by Robo receptor0.56
    Inactivation of Cdc42 and Rac0.56
    Inactivation of Cdc42 and Rac0.56
    2Axon guidance
    Axon guidance0.69
    Developmental Biology0.69
    3Rho GTPase cycle
    Signaling by Rho GTPases1.00
    Rho GTPase cycle1.00
    4G-protein signaling Regulation of RAC1 activity
    G-protein signaling Regulation of RAC1 activity0.88
    5Signaling by GPCR
    Signal Transduction0.55

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for SRGAP3
        G-protein signaling Regulation of RAC1 activity

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SRGAP3
        Guidance Cues and Growth Cone Motility
    Signaling by Slit

    1 GeneGo (Thomson Reuters) Pathway for SRGAP3
        G-protein signaling Regulation of RAC1 activity

    5/11        Reactome Pathways for SRGAP3 (see all 11)
        Signaling by Rho GTPases
    Developmental Biology
    Developmental Biology
    Signaling by Robo receptor
    Signaling by Robo receptor


    1         Kegg Pathway  (Kegg details for SRGAP3):
        Axon guidance


    SRGAP3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SRGAP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/16 Interacting proteins for SRGAP3 (O432952, 3 ENSP000003733474) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMARCA4P515323, ENSP000003507204I2D: score=2 STRING: ENSP00000350720
    DTNBP1Q96EV83, ENSP000003416804I2D: score=1 STRING: ENSP00000341680
    WASF1Q925583, ENSP000003524254I2D: score=3 STRING: ENSP00000352425
    SMARCC2Q8TAQ23, ENSP000002670644I2D: score=2 STRING: ENSP00000267064
    TNIKQ9UKE53, ENSP000003995114I2D: score=2 STRING: ENSP00000399511
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0051056regulation of small GTPase mediated signal transduction TAS--

    SRGAP3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for SRGAP3 (SRGP3)

    Search CenterWatch for drugs/clinical trials and news about SRGAP3 / SRGP3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SRGAP3 gene (3 alternative transcripts): 
    NM_001033116.1  NM_001033117.2  NM_014850.3  

    Unigene Cluster for SRGAP3:

    SLIT-ROBO Rho GTPase activating protein 3
    Hs.654743  [show with all ESTs]
    Unigene Representative Sequence: NM_014850
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000383836(uc003brf.1 uc003brg.1) ENST00000360413 ENST00000491467
    ENST00000520860 ENST00000518265 ENST00000475560 ENST00000433332(uc003bri.1)
    ENST00000485983(uc003brj.1) ENST00000470951(uc003brk.3) ENST00000480750
    ENST00000490889 ENST00000490348

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    8/131 QIAGEN miScript miRNA Assays for microRNAs that regulate SRGAP3 (see all 131):
    hsa-miR-376b hsa-miR-106a hsa-miR-1224-3p hsa-miR-1260b hsa-miR-519a hsa-miR-3916 hsa-miR-761 hsa-miR-525-3p
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    Additional mRNA sequence: 

    AB007871.2 AB032982.1 AF427144.1 AF464189.1 AK054831.1 BC039300.1 BC140004.1 

    13 DOTS entries:

    DT.100022855  DT.115476  DT.102822507  DT.120868755  DT.92068010  DT.95074380  DT.120868655  DT.91978030 
    DT.97825129  DT.99996993  DT.120868735  DT.86850643  DT.99929793 

    24/188 AceView cDNA sequences (see all 188):

    AA862796 CR626625 BM671019 T17310 BM992683 BX951675 AA729228 AY004333 
    BM671507 AW274711 BM976179 T16436 CB129099 AL562493 AB007871 AL390174 
    BU683286 BQ921719 BP374268 AI075759 AA337772 AF464189 BF108779 H22584 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SRGAP3 expression in normal human tissues (normalized intensities)      SRGAP3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTGGCAAT
    SRGAP3 Expression
    About this image


    SRGAP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/20 selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 27 entries
             Globus Pallidus
             cerebellum   
     
     Neural Tube (Nervous System)    fully expand to see all 6 entries
             Telencephalon
     
     Spinal Cord (Nervous System)    fully expand to see all 3 entries
             Dorsal Horn   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 2 entries
             colon ; peripheral nerve/ganglion   
             spinal/ganglion/dorsal root ganglion   
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Retina
             corneal epithelial basal cells   

    See SRGAP3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SRGAP3

    SOURCE GeneReport for Unigene cluster: Hs.654743

    UniProtKB/Swiss-Prot: SRGP3_HUMAN, O43295
    Tissue specificity: Highly expressed in adult and fetal brain. Expressed at low levels in kidney. Isoform 3 is
    expressed in the kidney but is absent in the brain

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SRGAP3 gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srgap31 , 5 SLIT-ROBO Rho GTPase activating protein 31, 5 92.36(n)1
    98.64(a)1
      6 (52.54 cM)5
    2593021  NM_080448.41  NP_536696.41 
     1127179715 
    chicken
    (Gallus gallus)
    Aves SRGAP31 SLIT-ROBO Rho GTPase activating protein 3 85.62(n)
    95.66(a)
      416115  NM_001030604.1  NP_001025775.1 
    lizard
    (Anolis carolinensis)
    Reptilia SRGAP36
    SLIT-ROBO Rho GTPase activating protein 3
    96(a)
    1 ↔ 1
    GL343273.1(1063698-1291606)
    zebrafish
    (Danio rerio)
    Actinopterygii srgap31 SLIT-ROBO Rho GTPase activating protein 3 77.51(n)
    87.88(a)
      561567  XM_684980.5  XP_690072.4 


    ENSEMBL Gene Tree for SRGAP3 (if available)
    TreeFam Gene Tree for SRGAP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SRGAP3 gene
    ARHGAP172  ARHGAP52  SRGAP12  ARHGAP242  ARHGAP222  ARHGAP352  ARHGAP82  ARHGAP442  
    ARHGAP12  PRR5-ARHGAP82  SH3BP12  ARHGAP252  SRGAP22  ARHGAP42  
    8 SIMAP similar genes for SRGAP3 using alignment to 2 protein entries:     SRGP3_HUMAN (see all proteins):
    KIAA1156    SRGAP1    SRGAP2C    SRGAP2    C1    ARHGAP4
    ARHGAP12    SRGAP3

    SRGAP3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5610 SNPs in SRGAP3 are shown (see all 5610)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0355504
    A breast cancer sample4--see VAR_0355502 L I mis40--------
    rs1929248641,2
    --9021779(+) ATTAAA/GTGAGA 2 -- int10--------
    rs1380007971,2
    --9022094(+) CTCTAC/TAATGG 2 -- int10--------
    rs170499131,2
    C,F,H--9022114(+) TCCTTG/ATAACC 2 -- int117Minor allele frequency- A:0.12NA NS EA WA 2128
    rs1490568251,2
    --9022322(+) CGTCAA/GACCAG 2 -- ut310--------
    rs177364551,2
    C,F,H--9022346(+) AATACG/ACGACA 2 -- ut31 ese311Minor allele frequency- A:0.01NA NS EA 684
    rs1855090151,2
    --9022407(+) GAAACA/GATATC 2 -- ut310--------
    rs1894135791,2
    --9022641(+) CTTCCA/GTCTAA 2 -- ut310--------
    rs1430519021,2
    --9022714(+) AACTCA/CCACAG 2 -- ut310--------
    rs730240511,2
    --9023027(+) CCCGAC/TTCCCA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for SRGAP3 (9022275 - 9272275 bp, first 250kb of SRGAP3)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for SRGAP3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2122831CNV Deletion18987734
    nsv3690CNV Insertion18451855
    esv25936CNV Loss19812545
    dgv276n21CNV Loss19592680
    nsv3689CNV Loss18451855
    nsv518352CNV Loss19592680
    nsv521065CNV Loss19592680
    nsv876523CNV Gain21882294
    nsv876514CNV Gain21882294


    Human Gene Mutation Database (HGMD): SRGAP3
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SRGAP3
    DNA2.0 Custom Variant and Variant Library Synthesis for SRGAP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606525    OMIM disorders: --

    UniProtKB/Swiss-Prot: SRGP3_HUMAN, O43295
  • Note=A chromosomal aberration involving SRGAP3 is found in a patient with severe idiopathic mental
    retardation. Translocation t(X;3)(p11.2;p25)

  • 10 diseases for SRGAP3:    About MalaCards
    mental disorders    atrioventricular septal defect    pilocytic astrocytoma    intellectual disability
    astrocytoma    mental retardation    schizophrenia    hepatitis b
    hepatitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for SRGAP3:
    Intellectual disability

    SRGAP3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): SRGAP3
    Human Genome Epidemiology (HuGE) Navigator: SRGAP3 (7 documents)

    Export disorders for SRGAP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SRGAP3 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with SRGAP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The novel Rho-GTPase activating gene MEGAP/ srGAP3 has a putative role in severe mental retardation. (PubMed id 12195014)1, 2, 3, 9 Endris V.... Rappold G.A. (2002)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924)1, 2 Voss M....Janssen O. (2009)
    4. Single-cell expression profiling of dopaminergic neur ons combined with association analysis identifies pyridoxal kinase as Parkinson 's disease gene. (PubMed id 20035503)1, 4 Elstner M....Turnbull D.M. (2009)
    5. The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling. (PubMed id 12447388)1, 2 Soderling S.H.... Scott J.D. (2002)
    6. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    7. Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway. (PubMed id 11672528)1, 2 Wong K.... Rao Y. (2001)
    8. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2 Ishikawa K....Ohara O. (1997)
    9. MEGAP impedes cell migration via regulating actin and microtubule dynamics and focal complex formation. (PubMed id 16730001)1, 9 Yang Y....Rappold G. (2006)
    10. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9901 HGNC: 19744 AceView: SRGAP2andRAD18 Ensembl:ENSG00000196220 euGenes: HUgn9901
    ECgene: SRGAP3 Kegg: 9901 H-InvDB: SRGAP3

    (According to HUGE)
    About This Section
    HUGE: KIAA0411 KIAA1156

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SRGAP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SRGAP3 gene:
    Search GeneIP for patents involving SRGAP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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