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Aliases for SRGAP3 Gene

Aliases for SRGAP3 Gene

  • SLIT-ROBO Rho GTPase Activating Protein 3 2 3
  • MEGAP 3 4 6
  • SLIT-ROBO Rho GTPase Activating Protein 2 2 3
  • Rho GTPase-Activating Protein 14 3 4
  • Mental Disorder-Associated GAP 3 4
  • ARHGAP14 3 4
  • KIAA0411 4 6
  • SRGAP2 3 4
  • WRP 3 4
  • WAVE-Associated Rac GTPase Activating Protein 3
  • WAVE-Associated Rac GTPase-Activating Protein 4
  • SLIT-ROBO Rho GTPase-Activating Protein 3 3
  • KIAA1156 4
  • SrGAP3 4

External Ids for SRGAP3 Gene

Previous Symbols for SRGAP3 Gene

  • SRGAP2

Summaries for SRGAP3 Gene

GeneCards Summary for SRGAP3 Gene

SRGAP3 (SLIT-ROBO Rho GTPase Activating Protein 3) is a Protein Coding gene. Diseases associated with SRGAP3 include pilocytic astrocytoma and 3p- syndrome. Among its related pathways are Signaling by GPCR and L1CAM interactions. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP22.

UniProtKB/Swiss-Prot for SRGAP3 Gene

  • GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons.

Gene Wiki entry for SRGAP3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRGAP3 Gene

Genomics for SRGAP3 Gene

Genomic Location for SRGAP3 Gene

Start:
8,980,591 bp from pter
End:
9,363,053 bp from pter
Size:
382,463 bases
Orientation:
Minus strand

Genomic View for SRGAP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SRGAP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRGAP3 Gene

Regulatory Elements for SRGAP3 Gene

Proteins for SRGAP3 Gene

  • Protein details for SRGAP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43295-SRGP3_HUMAN
    Recommended name:
    SLIT-ROBO Rho GTPase-activating protein 3
    Protein Accession:
    O43295
    Secondary Accessions:
    • Q8IX13
    • Q8IZV8

    Protein attributes for SRGAP3 Gene

    Size:
    1099 amino acids
    Molecular mass:
    124504 Da
    Quaternary structure:
    • Homodimer (Probable). Forms a heterooligomer with SRGAP1 and SRGAP2 through its F-BAR domain. Interacts with WASF1. Probably interacts with ROBO1. Interacts with FASLG.

    Alternative splice isoforms for SRGAP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRGAP3 Gene

Proteomics data for SRGAP3 Gene at MOPED

Post-translational modifications for SRGAP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SRGAP3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SRGAP3 Gene

Domains for SRGAP3 Gene

Gene Families for SRGAP3 Gene

HGNC:
  • ARHGAP :Rho GTPase activating proteins

UniProtKB/Swiss-Prot:

SRGP3_HUMAN
Domain:
  • The F-BAR domain mediates oligomerization, binds membranes, and induces plasma membrane protrusions:
    • O43295
  • Contains 1 F-BAR domain.:
    • O43295
  • Contains 1 Rho-GAP domain.:
    • O43295
  • Contains 1 SH3 domain.:
    • O43295
genes like me logo Genes that share domains with SRGAP3: view

Function for SRGAP3 Gene

Molecular function for SRGAP3 Gene

UniProtKB/Swiss-Prot Function: GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons.

Gene Ontology (GO) - Molecular Function for SRGAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 17500595
GO:0048365 Rac GTPase binding IBA --
genes like me logo Genes that share ontologies with SRGAP3: view

Phenotypes for SRGAP3 Gene

genes like me logo Genes that share phenotypes with SRGAP3: view

Animal Models for SRGAP3 Gene

MGI Knock Outs for SRGAP3:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SRGAP3 Gene

Localization for SRGAP3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRGAP3 Gene COMPARTMENTS Subcellular localization image for SRGAP3 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 4
cytosol 4
nucleus 2
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SRGAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SRGAP3: view

Pathways for SRGAP3 Gene

genes like me logo Genes that share pathways with SRGAP3: view

Pathways by source for SRGAP3 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for SRGAP3 Gene
2 Qiagen pathways for SRGAP3 Gene
1 KEGG pathway for SRGAP3 Gene

Gene Ontology (GO) - Biological Process for SRGAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0030336 negative regulation of cell migration IBA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with SRGAP3: view

Transcripts for SRGAP3 Gene

Unigene Clusters for SRGAP3 Gene

SLIT-ROBO Rho GTPase activating protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SRGAP3 Gene

No ASD Table

Relevant External Links for SRGAP3 Gene

GeneLoc Exon Structure for
SRGAP3
ECgene alternative splicing isoforms for
SRGAP3

Expression for SRGAP3 Gene

mRNA expression in normal human tissues for SRGAP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SRGAP3 Gene

This gene is overexpressed in Brain - Cerebellum (6.4) and Brain - Cerebellar Hemisphere (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SRGAP3 Gene

SOURCE GeneReport for Unigene cluster for SRGAP3 Gene Hs.654743

mRNA Expression by UniProt/SwissProt for SRGAP3 Gene

O43295-SRGP3_HUMAN
Tissue specificity: Highly expressed in adult and fetal brain. Expressed at low levels in kidney. Isoform 3 is expressed in the kidney but is absent in the brain.
genes like me logo Genes that share expressions with SRGAP3: view

Orthologs for SRGAP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SRGAP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRGAP3 36
  • 99.51 (n)
  • 99.9 (a)
SRGAP3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SRGAP3 36
  • 93.54 (n)
  • 99.27 (a)
SRGAP3 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRGAP3 36
  • 93.99 (n)
  • 99.36 (a)
SRGAP3 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srgap3 36
  • 92.36 (n)
  • 98.64 (a)
Srgap3 16
Srgap3 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SRGAP3 37
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRGAP3 37
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Srgap3 36
  • 92.36 (n)
  • 98.64 (a)
chicken
(Gallus gallus)
Aves SRGAP3 36
  • 85.62 (n)
  • 95.66 (a)
SRGAP3 37
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRGAP3 37
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia srgap3 36
  • 78.87 (n)
  • 88.11 (a)
zebrafish
(Danio rerio)
Actinopterygii srgap3 36
  • 77.93 (n)
  • 88 (a)
srgap3 37
  • 87 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F12F6.5 38
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 48 (a)
OneToMany
Species with no ortholog for SRGAP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRGAP3 Gene

ENSEMBL:
Gene Tree for SRGAP3 (if available)
TreeFam:
Gene Tree for SRGAP3 (if available)

Paralogs for SRGAP3 Gene

Selected SIMAP similar genes for SRGAP3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SRGAP3: view

Variants for SRGAP3 Gene

Sequence variations from dbSNP and Humsavar for SRGAP3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs2908 -- 9,009,592(+) CTATG(C/T)CTACT intron-variant
rs52451 -- 9,114,007(+) GGCCT(A/G)GCTCT intron-variant
rs124760 -- 9,115,935(+) CTGTT(C/G)TCTAT intron-variant
rs182912 -- 9,003,435(-) gtggc(A/G)caatc intron-variant
rs186889 -- 8,985,134(-) GTATA(C/T)GTATG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SRGAP3 Gene

Variant ID Type Subtype PubMed ID
nsv876514 CNV Gain 21882294
nsv518352 CNV Loss 19592680
nsv3689 CNV Loss 18451855
dgv276n21 CNV Loss 19592680
nsv521065 CNV Loss 19592680
nsv876523 CNV Gain 21882294
esv25936 CNV Loss 19812545
nsv3690 CNV Insertion 18451855
esv2122831 CNV Deletion 18987734

Relevant External Links for SRGAP3 Gene

HapMap Linkage Disequilibrium report
SRGAP3
Human Gene Mutation Database (HGMD)
SRGAP3

Disorders for SRGAP3 Gene

UniProtKB/Swiss-Prot

SRGP3_HUMAN
  • Note=A chromosomal aberration involving SRGAP3 is found in a patient with severe idiopathic mental retardation. Translocation t(X;3)(p11.2;p25).

(1) University of Copenhagen DISEASES for SRGAP3 Gene

Relevant External Links for SRGAP3

Genetic Association Database (GAD)
SRGAP3
Human Genome Epidemiology (HuGE) Navigator
SRGAP3
genes like me logo Genes that share disorders with SRGAP3: view

Publications for SRGAP3 Gene

  1. The novel Rho-GTPase activating gene MEGAP/ srGAP3 has a putative role in severe mental retardation. (PMID: 12195014) Endris V. … Rappold G.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 4 23
  2. MEGAP impedes cell migration via regulating actin and microtubule dynamics and focal complex formation. (PMID: 16730001) Yang Y. … Rappold G. (Exp. Cell Res. 2006) 3 23
  3. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K. … Ohara O. (DNA Res. 1997) 3 4
  4. Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway. (PMID: 11672528) Wong K. … Rao Y. (Cell 2001) 3 4
  5. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4

Products for SRGAP3 Gene

Sources for SRGAP3 Gene

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