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SRGAP3 Gene

protein-coding   GIFtS: 63
GCID: GC03M008998

SLIT-ROBO Rho GTPase Activating Protein 3

(Previous name: SLIT-ROBO Rho GTPase activating protein 2)
(Previous symbol: SRGAP2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SLIT-ROBO Rho GTPase Activating Protein 31 2     WRP2 3
SRGAP21 2 3     KIAA04113 5
MEGAP2 3 5     SLIT-ROBO Rho GTPase-Activating Protein 32
SLIT-ROBO Rho GTPase Activating Protein 21 2     WAVE-Associated Rac GTPase Activating Protein2
Mental Disorder-Associated GAP2 3     KIAA11563
Rho GTPase-Activating Protein 142 3     srGAP33
ARHGAP142 3     WAVE-Associated Rac GTPase-Activating Protein3

External Ids:    HGNC: 197441   Entrez Gene: 99012   Ensembl: ENSG000001962207   OMIM: 6065255   UniProtKB: O432953   

Export aliases for SRGAP3 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SRGAP3 Gene:
SRGAP3 (SLIT-ROBO Rho GTPase activating protein 3) is a protein-coding gene. Diseases associated with SRGAP3 include pilocytic astrocytoma, and atrioventricular septal defect. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP5.

UniProtKB/Swiss-Prot: SRGP3_HUMAN, O43295
Function: GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1
signaling in neurons

Gene Wiki entry for SRGAP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SRGAP3 gene promoter:
         HEN1   TBP   S8   p53   SEF-1 (1)   ITF-2   Tal-1beta   E47   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSRGAP3 promoter sequence
   Search Chromatin IP Primers for SRGAP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SRGAP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.3   Ensembl cytogenetic band:  3p25.3   HGNC cytogenetic band: 3p25.3

SRGAP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRGAP3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M008998:  view genomic region     (about GC identifiers)

Start:
9,022,275 bp from pter      End:
9,404,737 bp from pter
Size:
382,463 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SRGP3_HUMAN, O43295 (See protein sequence)
Recommended Name: SLIT-ROBO Rho GTPase-activating protein 3  
Size: 1099 amino acids; 124504 Da
Subunit: Homodimer (Probable). Forms a heterooligomer with SRGAP1 and SRGAP2 through its F-BAR domain. Interacts
with WASF1. Probably interacts with ROBO1. Interacts with FASLG
Secondary accessions: Q8IX13 Q8IZV8
Alternative splicing: 3 isoforms:  O43295-1   O43295-2   O43295-3   

Explore the universe of human proteins at neXtProt for SRGAP3: NX_O43295

Explore proteomics data for SRGAP3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SRGAP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001028289.1  NP_055665.1  

    ENSEMBL proteins: 
     ENSP00000373347   ENSP00000353587  
    Reactome Protein details: O43295

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARHGAP: Rho GTPase activating proteins

    4 InterPro protein domains:
     IPR001060 FCH_dom
     IPR008936 Rho_GTPase_activation_prot
     IPR001452 SH3_domain
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry O43295

    ProtoNet protein and cluster: O43295

    4 Blocks protein domains:
    IPB000198 RhoGAP domain
    IPB001060 Cdc15/Fes/CIP4
    IPB001452 SH3 domain signature
    IPB002017 Spectrin repeat


    UniProtKB/Swiss-Prot: SRGP3_HUMAN, O43295
    Domain: The F-BAR domain mediates oligomerization, binds membranes, and induces plasma membrane protrusions
    Similarity: Contains 1 FCH domain
    Similarity: Contains 1 Rho-GAP domain
    Similarity: Contains 1 SH3 domain


    SRGAP3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRGP3_HUMAN, O43295
    Function: GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1
    signaling in neurons

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IEA--
    GO:0005515protein binding IPI17500595
         
    SRGAP3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SRGAP3:
     Increased G1 DNA content 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Srgap3):
     behavior/neurological  homeostasis/metabolism  mortality/aging  nervous system 

    SRGAP3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SRGAP3: Srgap3tm1.1Zi Srgap3tm1.1Ssod

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SRGAP3
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    miRNA
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    miRTarBase miRNAs that target SRGAP3:
    hsa-mir-98-5p (MIRT027717), hsa-mir-186-5p (MIRT045164), hsa-mir-125a-5p (MIRT045756), hsa-mir-214-3p (MIRT024967), hsa-mir-191-5p (MIRT045795), hsa-mir-7-5p (MIRT025878)

    Block miRNA regulation of human, mouse, rat SRGAP3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SRGAP3 (see all 131):
    hsa-miR-376b hsa-miR-106a hsa-miR-1224-3p hsa-miR-1260b hsa-miR-519a hsa-miR-3916 hsa-miR-761 hsa-miR-525-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SRGAP3

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRGAP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRGAP3

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRGAP3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton4
    cytosol4
    nucleus2
    golgi apparatus1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--

    SRGAP3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SRGAP3 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    2Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    3Signaling by Robo receptor
    Inactivation of Cdc42 and Rac0.00
    Signaling by Robo receptor
    4Signaling by GPCR
    Signal Transduction0.58
    5Signaling by Slit
    Signaling by Slit

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SRGAP3
        Guidance Cues and Growth Cone Motility
    Signaling by Slit

    1 GeneGo (Thomson Reuters) Pathway for SRGAP3
        G-protein signaling Regulation of RAC1 activity

    2 Reactome Pathways for SRGAP3
        Inactivation of Cdc42 and Rac
    Rho GTPase cycle


    1 Kegg Pathway  (Kegg details for SRGAP3):
        Axon guidance


    SRGAP3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SRGAP3
    Interactions:

        GeneGlobe Interaction Network for SRGAP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for SRGAP3 (O432952, 3 ENSP000003733474) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMARCA4P515323, ENSP000003507204I2D: score=2 STRING: ENSP00000350720
    DTNBP1Q96EV83, ENSP000003416804I2D: score=1 STRING: ENSP00000341680
    WASF1Q925583, ENSP000003524254I2D: score=3 STRING: ENSP00000352425
    SMARCC2Q8TAQ23, ENSP000002670644I2D: score=2 STRING: ENSP00000267064
    TNIKQ9UKE53, ENSP000003995114I2D: score=2 STRING: ENSP00000399511
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0051056regulation of small GTPase mediated signal transduction TAS--

    SRGAP3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SRGAP3 (SRGP3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SRGAP3 gene (3 alternative transcripts): 
    NM_001033116.1  NM_001033117.2  NM_014850.3  

    Unigene Cluster for SRGAP3:

    SLIT-ROBO Rho GTPase activating protein 3
    Hs.654743  [show with all ESTs]
    Unigene Representative Sequence: NM_014850
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000383836(uc003brf.1 uc003brg.1) ENST00000360413 ENST00000491467
    ENST00000520860 ENST00000518265 ENST00000475560 ENST00000433332(uc003bri.1)
    ENST00000485983(uc003brj.1) ENST00000470951(uc003brk.3) ENST00000480750
    ENST00000490889 ENST00000490348
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SRGAP3 (see all 131):
    hsa-miR-376b hsa-miR-106a hsa-miR-1224-3p hsa-miR-1260b hsa-miR-519a hsa-miR-3916 hsa-miR-761 hsa-miR-525-3p
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    Additional mRNA sequence: 

    AB007871.2 AB032982.1 AF427144.1 AF464189.1 AK054831.1 BC039300.1 BC140004.1 

    13 DOTS entries:

    DT.100022855  DT.115476  DT.102822507  DT.120868755  DT.92068010  DT.95074380  DT.120868655  DT.91978030 
    DT.97825129  DT.99996993  DT.120868735  DT.86850643  DT.99929793 

    Selected AceView cDNA sequences (see all 188):

    AK126331 AF427144 BX281377 AL390174 AA972797 AW274711 BM671019 AA337772 
    CR598315 T16436 AI075759 BM671507 AA729228 NM_014850 BM704301 AY004333 
    T17310 AA862796 CB129099 BM992683 BF108779 BQ878144 BX118224 CB146761 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SRGAP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTGGCAAT
    SRGAP3 Expression
    About this image


    SRGAP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Common Dendritic Cell Precursors Hematopoietic Bone Marrow
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Midbrain tegmentum
     
     NULL (Uncategorized)
             Neural rosettes
     
     Kidney (Urinary System)
             Metanephros
    SRGAP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SRGAP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654743

    UniProtKB/Swiss-Prot: SRGP3_HUMAN, O43295
    Tissue specificity: Highly expressed in adult and fetal brain. Expressed at low levels in kidney. Isoform 3 is
    expressed in the kidney but is absent in the brain

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRGAP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SRGAP3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srgap31 , 5 SLIT-ROBO Rho GTPase activating protein 31, 5 92.36(n)1
    98.64(a)1
      6 (52.54 cM)5
    2593021  NM_080448.41  NP_536696.41 
     1127179715 
    chicken
    (Gallus gallus)
    Aves SRGAP31 SLIT-ROBO Rho GTPase activating protein 3 85.62(n)
    95.66(a)
      416115  NM_001030604.2  NP_001025775.1 
    lizard
    (Anolis carolinensis)
    Reptilia SRGAP36
    SLIT-ROBO Rho GTPase activating protein 3
    96(a)
    1 ↔ 1
    GL343273.1(1063698-1291606)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia srgap31 SLIT-ROBO Rho GTPase activating protein 3 78.87(n)
    88.11(a)
      100494228  XM_002936253.2  XP_002936299.1 
    zebrafish
    (Danio rerio)
    Actinopterygii srgap31 SLIT-ROBO Rho GTPase activating protein 3 77.93(n)
    88(a)
      561567  XM_005166115.1  XP_005166172.1 


    ENSEMBL Gene Tree for SRGAP3 (if available)
    TreeFam Gene Tree for SRGAP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SRGAP3 gene
    ARHGAP52  ARHGAP172  SRGAP12  ARHGAP242  ARHGAP222  ARHGAP352  ARHGAP442  SH3BP12  
    ARHGAP252  SRGAP22  ARHGAP42  
    8 SIMAP similar genes for SRGAP3 using alignment to 2 protein entries:     SRGP3_HUMAN (see all proteins):
    KIAA1156    SRGAP1    SRGAP2C    SRGAP2    C1    ARHGAP4
    ARHGAP12    SRGAP3

    SRGAP3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SRGAP3 (see all 5610)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0355504
    A breast cancer sample4--see VAR_0355502 L I mis40--------
    rs1929248641,2
    --9021779(+) ATTAAA/GTGAGA 2 -- int10--------
    rs1380007971,2
    --9022094(+) CTCTAC/TAATGG 2 -- int10--------
    rs170499131,2
    C,F,H--9022114(+) TCCTTG/ATAACC 2 -- int117Minor allele frequency- A:0.12NA NS EA WA 2128
    rs1490568251,2
    --9022322(+) CGTCAA/GACCAG 2 -- ut310--------
    rs177364551,2
    C,F,H--9022346(+) AATACG/ACGACA 2 -- ut31 ese311Minor allele frequency- A:0.01NA NS EA 684
    rs1855090151,2
    --9022407(+) GAAACA/GATATC 2 -- ut310--------
    rs1894135791,2
    --9022641(+) CTTCCA/GTCTAA 2 -- ut310--------
    rs1430519021,2
    --9022714(+) AACTCA/CCACAG 2 -- ut310--------
    rs730240511,2
    --9023027(+) CCCGAC/TTCCCA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for SRGAP3 (9022275 - 9272275 bp, first 250kb of SRGAP3)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for SRGAP3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2122831CNV Deletion18987734
    nsv3690CNV Insertion18451855
    esv25936CNV Loss19812545
    dgv276n21CNV Loss19592680
    nsv3689CNV Loss18451855
    nsv518352CNV Loss19592680
    nsv521065CNV Loss19592680
    nsv876523CNV Gain21882294
    nsv876514CNV Gain21882294

    Human Gene Mutation Database (HGMD): SRGAP3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SRGAP3
    DNA2.0 Custom Variant and Variant Library Synthesis for SRGAP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606525    OMIM disorders: --

    UniProtKB/Swiss-Prot: SRGP3_HUMAN, O43295
  • Note=A chromosomal aberration involving SRGAP3 is found in a patient with severe idiopathic mental
    retardation. Translocation t(X;3)(p11.2;p25)

  • 16 diseases for SRGAP3:    
    About MalaCards
    pilocytic astrocytoma    atrioventricular septal defect    intellectual disability    astrocytoma
    labyrinthitis    mental retardation    breast and colorectal cancer    parkinson's disease
    schizophrenia    hepatitis b    hepatitis    colorectal cancer
    multiple myeloma    cerebritis    myeloma    neuronitis

    1 disease from the University of Copenhagen DISEASES database for SRGAP3:
    Intellectual disability

    SRGAP3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SRGAP3
    Human Genome Epidemiology (HuGE) Navigator: SRGAP3 (7 documents)

    Export disorders for SRGAP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SRGAP3 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with SRGAP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The novel Rho-GTPase activating gene MEGAP/ srGAP3 has a putative role in severe mental retardation. (PubMed id 12195014)1, 2, 3, 9 Endris V.... Rappold G.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924)1, 2 Voss M.... Janssen O. (BMC Immunol. 2009)
    4. Single-cell expression profiling of dopaminergic neurons combined with association analysis identifies pyridoxal kinase as Parkinson's disease gene. (PubMed id 20035503)1, 4 Elstner M....Turnbull D.M. (Ann. Neurol. 2009)
    5. The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling. (PubMed id 12447388)1, 2 Soderling S.H.... Scott J.D. (Nat. Cell Biol. 2002)
    6. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    7. Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway. (PubMed id 11672528)1, 2 Wong K.... Rao Y. (Cell 2001)
    8. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2 Ishikawa K.... Ohara O. (DNA Res. 1997)
    9. MEGAP impedes cell migration via regulating actin and microtubule dynamics and focal complex formation. (PubMed id 16730001)1, 9 Yang Y....Rappold G. (Exp. Cell Res. 2006)
    10. A tumor suppressor role for srGAP3 in mammary epithelial cells. (PubMed id 23108406)1 Lahoz A. and Hall A. (Oncogene 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9901 HGNC: 19744 AceView: SRGAP2andRAD18 Ensembl:ENSG00000196220 euGenes: HUgn9901
    ECgene: SRGAP3 Kegg: 9901 H-InvDB: SRGAP3

    (According to HUGE)
    About This Section

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    HUGE: KIAA0411 KIAA1156

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SRGAP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SRGAP3 gene:
    Search GeneIP for patents involving SRGAP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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