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Aliases for SRGAP2C Gene

Aliases for SRGAP2C Gene

  • SLIT-ROBO Rho GTPase Activating Protein 2C 2 3
  • SLIT-ROBO Rho GTPase Activating Protein 2 Pseudogene 1 2 3 4
  • SRGAP2P1 3 4
  • SLIT-ROBO Rho GTPase-Activating Protein 2C 3

External Ids for SRGAP2C Gene

Previous Symbols for SRGAP2C Gene

  • SRGAP2P1

Summaries for SRGAP2C Gene

Entrez Gene Summary for SRGAP2C Gene

  • This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. This human-specific locus resulted from segmental duplication of the SLIT-ROBO Rho GTPase activating protein 2B locus. The encoded protein lacks the GTPase activating protein domain compared to proteins encoded by SLIT-ROBO Rho GTPase activating protein 2, and acts antagonistically to these proteins in cortical neuron development. [provided by RefSeq, Dec 2012]

GeneCards Summary for SRGAP2C Gene

SRGAP2C (SLIT-ROBO Rho GTPase Activating Protein 2C) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and protein heterodimerization activity.

UniProtKB/Swiss-Prot for SRGAP2C Gene

  • Involved in dendritic spine maturation through interaction with and inhibition of SRGAP2. Reduces the rate of spine maturation and indirectly increases neuronal migration. Changes dendritic spine morphology and density and may have implications for cognition, learning and memory.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRGAP2C Gene

Genomics for SRGAP2C Gene

Genomic Location for SRGAP2C Gene

Start:
121,184,810 bp from pter
End:
121,392,822 bp from pter
Size:
208,013 bases
Orientation:
Plus strand

Genomic View for SRGAP2C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SRGAP2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRGAP2C Gene

No data available for Regulatory Elements for SRGAP2C Gene

Proteins for SRGAP2C Gene

  • Protein details for SRGAP2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DJJ0-SRG2C_HUMAN
    Recommended name:
    SLIT-ROBO Rho GTPase-activating protein 2C
    Protein Accession:
    P0DJJ0
    Secondary Accessions:

    Protein attributes for SRGAP2C Gene

    Size:
    459 amino acids
    Molecular mass:
    53484 Da
    Quaternary structure:
    • Homodimer. Interacts with SRGAP2; formation of the heterodimer alters SRGAP2 function.
    Miscellaneous:
    • This is one of the 3 duplications of the ancestral gene SRGAP2 which has undergone human-specific segmental gene duplications. The appearance of SRGAP2C in the human genome is estimated to 2,4 million years and corresponds to the beginning of neocortex expansion in human evolution. SRGAP2C may have, therefore, played an important role in this process. 2 other copies of SRGAP2, SRGAP2B and SRGAP2D, were identified in some individuals but it is not clear if they produce a functional protein (PubMed:22559944). SRGAP2C is the only copy to be fixed at a diploid state in the genome and to exhibit strong mRNA expression. A cDNA specific for that gene was used in the functional study (PubMed:22559944).

neXtProt entry for SRGAP2C Gene

Proteomics data for SRGAP2C Gene at MOPED

Post-translational modifications for SRGAP2C Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys33

Other Protein References for SRGAP2C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SRGAP2C Gene

Domains for SRGAP2C Gene

Protein Domains for SRGAP2C Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

SRG2C_HUMAN
Domain:
  • Contains 1 F-BAR domain.:
    • P0DJJ0
genes like me logo Genes that share domains with SRGAP2C: view

No data available for Gene Families for SRGAP2C Gene

Function for SRGAP2C Gene

Molecular function for SRGAP2C Gene

UniProtKB/Swiss-Prot Function: Involved in dendritic spine maturation through interaction with and inhibition of SRGAP2. Reduces the rate of spine maturation and indirectly increases neuronal migration. Changes dendritic spine morphology and density and may have implications for cognition, learning and memory.

Gene Ontology (GO) - Molecular Function for SRGAP2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042803 protein homodimerization activity IPI 22559944
GO:0046872 metal ion binding --
GO:0046982 protein heterodimerization activity IPI 22559944
genes like me logo Genes that share ontologies with SRGAP2C: view

miRNA for SRGAP2C Gene

miRTarBase miRNAs that target SRGAP2C

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SRGAP2C Gene

Localization for SRGAP2C Gene

No data available for Gene Ontology (GO) - Cellular Components for SRGAP2C Gene

Pathways for SRGAP2C Gene

SuperPathways for SRGAP2C Gene

No Data Available

Interacting Proteins for SRGAP2C Gene

Gene Ontology (GO) - Biological Process for SRGAP2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0021816 extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration IDA 22559944
GO:0030001 metal ion transport --
GO:0051490 negative regulation of filopodium assembly IDA 22559944
GO:0061000 negative regulation of dendritic spine development IDA 22559944
GO:2001224 positive regulation of neuron migration IDA 22559944
genes like me logo Genes that share ontologies with SRGAP2C: view

No data available for Pathways by source for SRGAP2C Gene

Transcripts for SRGAP2C Gene

mRNA/cDNA for SRGAP2C Gene

(6) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SRGAP2C Gene

SLIT-ROBO Rho GTPase activating protein 2C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SRGAP2C Gene

No ASD Table

Relevant External Links for SRGAP2C Gene

GeneLoc Exon Structure for
SRGAP2C
ECgene alternative splicing isoforms for
SRGAP2C

Expression for SRGAP2C Gene

mRNA expression in normal human tissues for SRGAP2C Gene

mRNA differential expression in normal tissues according to GTEx for SRGAP2C Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (6.7) and Brain - Cerebellum (5.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SRGAP2C Gene

SOURCE GeneReport for Unigene cluster for SRGAP2C Gene Hs.523529

mRNA Expression by UniProt/SwissProt for SRGAP2C Gene

P0DJJ0-SRG2C_HUMAN
Tissue specificity: Ubiquitously expressed with higher expression in cerebellum. Probably expressed in fetal and adult neurons (at protein level).
genes like me logo Genes that share expressions with SRGAP2C: view

Orthologs for SRGAP2C Gene

Evolution for SRGAP2C Gene

ENSEMBL:
Gene Tree for SRGAP2C (if available)
TreeFam:
Gene Tree for SRGAP2C (if available)

No data available for Orthologs for SRGAP2C Gene

Paralogs for SRGAP2C Gene

Selected SIMAP similar genes for SRGAP2C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SRGAP2C: view

No data available for Paralogs for SRGAP2C Gene

Variants for SRGAP2C Gene

Sequence variations from dbSNP and Humsavar for SRGAP2C Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs506108 -- 121,199,663(-) caggc(A/G)cctgc intron-variant
rs559004 -- 121,200,822(+) TCTCA(A/G)CTTCT intron-variant
rs561290 -- 121,270,886(+) CTCCC(A/G)GGTTC intron-variant
rs563035 -- 121,271,039(+) TGGTC(C/T)GCCTG intron-variant
rs563063 -- 121,271,046(+) CCTGC(A/C)TTGGC intron-variant

Relevant External Links for SRGAP2C Gene

HapMap Linkage Disequilibrium report
SRGAP2C

No data available for Structural Variations from Database of Genomic Variants (DGV) for SRGAP2C Gene

Disorders for SRGAP2C Gene

No disorders were found for SRGAP2C Gene.

No data available for UniProtKB/Swiss-Prot for SRGAP2C Gene

Publications for SRGAP2C Gene

  1. Evolution of human-specific neural SRGAP2 genes by incomplete segmental duplication. (PMID: 22559943) Dennis M.Y. … Eichler E.E. (Cell 2012) 2 3 4
  2. Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny during spine maturation. (PMID: 22559944) Charrier C. … Polleux F. (Cell 2012) 2 3 4
  3. A COFRADIC protocol to study protein ubiquitination. (PMID: 24816145) Stes E. … Gevaert K. (J. Proteome Res. 2014) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4

Products for SRGAP2C Gene

Sources for SRGAP2C Gene

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