Aliases for SRGAP2C Gene
External Ids for SRGAP2C Gene
Previous HGNC Symbols for SRGAP2C Gene
Previous GeneCards Identifiers for SRGAP2C Gene
This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. This human-specific locus resulted from segmental duplication of the SLIT-ROBO Rho GTPase activating protein 2B locus. The encoded protein lacks the GTPase activating protein domain compared to proteins encoded by SLIT-ROBO Rho GTPase activating protein 2, and acts antagonistically to these proteins in cortical neuron development. [provided by RefSeq, Dec 2012]
GeneCards Summary for SRGAP2C Gene
SRGAP2C (SLIT-ROBO Rho GTPase Activating Protein 2C) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is SRGAP2B.
UniProtKB/Swiss-Prot for SRGAP2C Gene
Involved in dendritic spine maturation through interaction with and inhibition of SRGAP2. Reduces the rate of spine maturation and indirectly increases neuronal migration. Changes dendritic spine morphology and density and may have implications for cognition, learning and memory.