SRGAP2C Gene
protein-coding GIFtS: 26
GCID: GC01P121091
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SLIT-ROBO Rho GTPase activating protein 2C(Previous name: SLIT-ROBO Rho GTPase activating protein 2 pseudogene 1...)
(Previous symbol: SRGAP2P1)
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Aliases
for SRGAP2C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SLIT-ROBO Rho GTPase Activating Protein 2C1 2 | | SRGAP2P11 2 3 | | SLIT-ROBO Rho GTPase Activating Protein 2 Pseudogene 11 2 3 | | SLIT-ROBO Rho GTPase-Activating Protein 2C2 |
Export aliases for SRGAP2C gene to outside databases |
Summaries
for SRGAP2C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SRGAP2C:
This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. This human-specific locus resultedfrom segmental duplication of the SLIT-ROBO Rho GTPase activating protein 2B locus. The encoded protein lacks theGTPase activating protein domain compared to proteins encoded by SLIT-ROBO Rho GTPase activating protein 2, and actsantagonistically to these proteins in cortical neuron development. (provided by RefSeq, Dec 2012)
UniProtKB/Swiss-Prot: SRG2C_HUMAN, P0DJJ0Function: Involved in dendritic spine maturation through interaction with and inhibition of SRGAP2. Reduces the rate ofspine maturation and indirectly increases neuronal migration. Changes dendritic spine morphology and density and mayhave implications for cognition, learning and memory
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Genomic Views
for SRGAP2C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_077389.3
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for SRGAP2C
Other transcription factors
Search SABiosciences Chromatin IP Primers for SRGAP2C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRGAP2C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p11.2 Ensembl cytogenetic band: 1p11.2 HGNC cytogenetic band: 1p11.2SRGAP2C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P121091: view genomic region
(about GC identifiers)
Start:
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121,090,793 bp from pter |
End:
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121,134,742 bp from pter |
Size:
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43,950 bases |
Orientation:
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plus strand |
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Proteins
for SRGAP2C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: SRG2C_HUMAN, P0DJJ0 (See
protein sequence)Recommended Name: SLIT-ROBO Rho GTPase-activating protein 2C Size: 459 amino acids; 53484 Da
Subunit: Homodimer. Interacts with SRGAP2; formation of the heterodimer alters SRGAP2 function
Miscellaneous: This is one of the 3 duplications of the ancestral gene SRGAP2 which has undergone human-specificsegmental gene duplications. The appearance of SRGAP2C in the human genome is estimated to 2,4 million years ago,corresponding to the beginning of neocortex expansion in human evolution and it may have played an important role inthis process. There are 2 other incomplete copies of SRGAP2 depending on individuals but SRGAP2C is the only one to befixed at a diploid state in the genome and to exhibit strong mRNA expression. A cDNA specific for that gene was usedin the functional study (PubMed:22559944)
Caution: The retained sequence for SRGAP2C might not align to the reference genome due to assembly discrepanciesExplore the universe of human proteins at neXtProt for SRGAP2C: NX_P0DJJ0
SRGAP2C Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001258801.1
Human Recombinant Protein Products for SRGAP2C:
SRGAP2C Antibody Products:
Assay Products for SRGAP2C: |
Protein
Domains /
Families
for SRGAP2C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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SRGAP2C for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P0DJJ0ProtoNet protein and cluster: P0DJJ0 UniProtKB/Swiss-Prot: SRG2C_HUMAN, P0DJJ0Similarity: Contains 1 FCH domain |
Function
for SRGAP2C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Molecular Function:
UniProtKB/Swiss-Prot Summary: SRG2C_HUMAN, P0DJJ0Function: Involved in dendritic spine maturation through interaction with and inhibition of SRGAP2. Reduces the rate ofspine maturation and indirectly increases neuronal migration. Changes dendritic spine morphology and density and mayhave implications for cognition, learning and memory Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0042803 | protein homodimerization activity |
IPI | -- | | GO:0046982 | protein heterodimerization activity |
IPI | -- |
SRGAP2C for ontologies About GeneDecksing
Animal Models:
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Pathways & Interactions
for SRGAP2C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SRGAP2C
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0021816 | extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration |
IDA | -- | | GO:0051490 | negative regulation of filopodium assembly |
IDA | -- | | GO:0061000 | negative regulation of dendritic spine development |
IDA | -- | | GO:2001224 | positive regulation of neuron migration |
IDA | -- |
SRGAP2C for ontologies About GeneDecksing
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Drugs & Compounds
for SRGAP2C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SRGAP2C
Search CenterWatch for drugs/clinical trials and news about SRGAP2C / SRG2C 
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Transcripts
for SRGAP2C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for SRGAP2C gene: NM_001271872.1 Unigene Cluster for SRGAP2C: SLIT-ROBO Rho GTPase activating protein 2C Hs.523529 [show with all ESTs]Unigene Representative Sequence: BC0179722 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000304465 ENST00000367123(uc001eis.2)
Additional cDNA sequence: BC017972.1 DQ786199.1 10 DOTS entries: DT.412097 DT.121370749 DT.121370688 DT.121460324 DT.121426206 DT.434729 DT.92420779 DT.95254487 DT.120678401 DT.95254488
GeneLoc Exon Structure
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Expression
for SRGAP2C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
Genevestigator expression for SRGAP2C
SOURCE GeneReport for Unigene cluster: Hs.523529
UniProtKB/Swiss-Prot: SRG2C_HUMAN, P0DJJ0Tissue specificity: Ubiquitously expressed with higher expression in cerebellum. Probably expressed in fetal and adultneurons (at protein level)
SABiosciences Custom PCR Arrays for SRGAP2C
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat SRGAP2C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRGAP2C | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRGAP2C |
Orthologs
for SRGAP2C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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--
ENSEMBL Gene Tree for SRGAP2C (if available)
TreeFam Gene Tree for SRGAP2C (if available) |
Paralogs
for SRGAP2C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SRGAP2C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for SRGAP2C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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SRGAP2C for disorders About GeneDecksing
OMIM gene information: 614704
OMIM disorders: --
2  diseases for SRGAP2C: About MalaCardscerebritis neuronitis
Export disorders for SRGAP2C gene to outside databases
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Publications
for SRGAP2C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SRGAP2C gene integrated from 9 sources:
(articles sorted by number of sources associating them with SRGAP2C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Evolution of human-specific neural SRGAP2 genes by incomplete segmental duplication. (PubMed id 22559943)1, 2, 3 Dennis M.Y....Eichler E.E. (2012)
- Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny during spine maturation. (PubMed id 22559944)1, 2, 3 Charrier C....Polleux F. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PubMed id 17903296)1 Kiel D.P....Karasik D. (2007)
- Lineage-specific gene duplication and loss in human and great ape evolution. (PubMed id 15252450)1 Fortna A....Sikela J.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for SRGAP2C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing SRGAP2C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing SRGAP2C gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SRGAP2C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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About This Section
| Patent Information for SRGAP2C gene:
Search GeneIP for patents involving SRGAP2C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SRGAP2C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SRGAP2C | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SRGAP2C | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRGAP2C | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRGAP2C | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRGAP2C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRGAP2C |
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| | | | Search Tocris compounds for SRGAP2C |
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 | | | | |  |  |  |  | | | | Search ThermoFisher Antibodies for SRGAP2C |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SRGAP2C |
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