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Aliases for SRGAP2B Gene

Aliases for SRGAP2B Gene

  • SLIT-ROBO Rho GTPase Activating Protein 2B 2 3
  • SLIT-ROBO Rho GTPase Activating Protein 2 Pseudogene 2 2 3 4
  • SLIT-ROBO Rho GTPase Activating Protein 2B (Pseudogene) 2 3
  • SRGAP2P2 3 4
  • SLIT-ROBO Rho GTPase-Activating Protein 2B 3
  • SRGAP2L 3

External Ids for SRGAP2B Gene

Previous HGNC Symbols for SRGAP2B Gene

  • SRGAP2P2

Previous GeneCards Identifiers for SRGAP2B Gene

  • GC01P143915

Summaries for SRGAP2B Gene

Entrez Gene Summary for SRGAP2B Gene

  • This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. This human-specific locus resulted from incomplete segmental duplication of the SLIT-ROBO Rho GTPase activating protein 2 locus. The encoded protein lacks the GTPase activating protein domain compared to proteins encoded by SLIT-ROBO Rho GTPase activating protein 2. The functionality of the protein encoded by this locus has been questioned, as several normal individuals with homozygous deletions for this locus have been identified, and the expression of this locus appears to be much lower than the similar SLIT-ROBO Rho GTPase activating protein 2C (SRGAP2C) locus. The SRGAP2C locus has been shown to encode a protein that functions antagonistically to SLIT-ROBO Rho GTPase activating protein 2 in cortical neuron development. [provided by RefSeq, Dec 2012]

GeneCards Summary for SRGAP2B Gene

SRGAP2B (SLIT-ROBO Rho GTPase Activating Protein 2B) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SRGAP2B Gene

  • May regulate cell migration and differentiation through interaction with and inhibition of SRGAP2.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRGAP2B Gene

Genomics for SRGAP2B Gene

Genomic Location for SRGAP2B Gene

Start:
144,887,265 bp from pter
End:
145,095,528 bp from pter
Size:
208,264 bases
Orientation:
Minus strand

Genomic View for SRGAP2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SRGAP2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRGAP2B Gene

No data available for Regulatory Elements for SRGAP2B Gene

Proteins for SRGAP2B Gene

  • Protein details for SRGAP2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DMP2-SRG2B_HUMAN
    Recommended name:
    SLIT-ROBO Rho GTPase-activating protein 2B
    Protein Accession:
    P0DMP2
    Secondary Accessions:

    Protein attributes for SRGAP2B Gene

    Size:
    458 amino acids
    Molecular mass:
    53406 Da
    Quaternary structure:
    • Homodimer. Interacts with SRGAP2; formation of the heterodimer alters SRGAP2 function (By similarity).
    Miscellaneous:
    • This is one of the 3 duplications of the ancestral gene SRGAP2 which has undergone human-specific segmental gene duplications. The appearance of SRGAP2B in the human genome is estimated to 3,4 million years. Two larger duplications later copied SRGAP2B to chromosome 1p12 (SRGAP2C) and to proximal 1q21.1 (SRGAP2D). SRGAP2B was identified in some individuals but it is not clear if it produces a functional protein (PubMed:22559944).

neXtProt entry for SRGAP2B Gene

Proteomics data for SRGAP2B Gene at MOPED

Post-translational modifications for SRGAP2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SRGAP2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SRGAP2B Gene

Domains for SRGAP2B Gene

Protein Domains for SRGAP2B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P0DMP2

UniProtKB/Swiss-Prot:

SRG2B_HUMAN :
  • P0DMP2
Domain:
  • Contains 1 F-BAR domain.
genes like me logo Genes that share domains with SRGAP2B: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for SRGAP2B Gene

Function for SRGAP2B Gene

Molecular function for SRGAP2B Gene

UniProtKB/Swiss-Prot Function:
May regulate cell migration and differentiation through interaction with and inhibition of SRGAP2.

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SRGAP2B Gene

Localization for SRGAP2B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for SRGAP2B Gene

Pathways for SRGAP2B Gene

SuperPathways for SRGAP2B Gene

No Data Available

Interacting Proteins for SRGAP2B Gene

Gene Ontology (GO) - Biological Process for SRGAP2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development IEA --
genes like me logo Genes that share ontologies with SRGAP2B: view

No data available for Pathways by source for SRGAP2B Gene

Transcripts for SRGAP2B Gene

mRNA/cDNA for SRGAP2B Gene

(6) REFSEQ mRNAs :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for SRGAP2B Gene

No ASD Table

Relevant External Links for SRGAP2B Gene

GeneLoc Exon Structure for
SRGAP2B
ECgene alternative splicing isoforms for
SRGAP2B

Expression for SRGAP2B Gene

mRNA expression in normal human tissues for SRGAP2B Gene

mRNA differential expression in normal tissues according to GTEx for SRGAP2B Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (6.4) and Brain - Cerebellum (4.9).

Protein differential expression in normal tissues for SRGAP2B Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SRGAP2B Gene

genes like me logo Genes that share expressions with SRGAP2B: view

Expression partners for SRGAP2B Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SRGAP2B Gene

Orthologs for SRGAP2B Gene

Evolution for SRGAP2B Gene

ENSEMBL:
Gene Tree for SRGAP2B (if available)
TreeFam:
Gene Tree for SRGAP2B (if available)

No data available for Orthologs for SRGAP2B Gene

Paralogs for SRGAP2B Gene

No data available for Paralogs for SRGAP2B Gene

Variants for SRGAP2B Gene

Sequence variations from dbSNP and Humsavar for SRGAP2B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs472468 -- 145,080,703(+) gcgcc(C/T)gccac intron-variant
rs473338 -- 145,080,797(-) caggc(A/G)gatca intron-variant
rs474870 -- 145,064,230(+) CATGT(C/G)ACAGT intron-variant
rs476561 -- 144,957,188(+) TACAA(A/G)GAAAG intron-variant
rs476742 -- 144,957,109(-) aatga(C/G)agtac intron-variant

Relevant External Links for SRGAP2B Gene

HapMap Linkage Disequilibrium report
SRGAP2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SRGAP2B Gene

Disorders for SRGAP2B Gene

No disorders were found for SRGAP2B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for SRGAP2B Gene

Publications for SRGAP2B Gene

  1. Evolution of human-specific neural SRGAP2 genes by incomplete segmental duplication. (PMID: 22559943) Dennis M.Y. … Eichler E.E. (Cell 2012) 2 3 4
  2. Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny during spine maturation. (PMID: 22559944) Charrier C. … Polleux F. (Cell 2012) 2 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SRGAP2B Gene

Sources for SRGAP2B Gene

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