Aliases for SRGAP2B Gene
External Ids for SRGAP2B Gene
Previous HGNC Symbols for SRGAP2B Gene
Previous GeneCards Identifiers for SRGAP2B Gene
This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. This human-specific locus resulted from incomplete segmental duplication of the SLIT-ROBO Rho GTPase activating protein 2 locus. The encoded protein lacks the GTPase activating protein domain compared to proteins encoded by SLIT-ROBO Rho GTPase activating protein 2. The functionality of the protein encoded by this locus has been questioned, as several normal individuals with homozygous deletions for this locus have been identified, and the expression of this locus appears to be much lower than the similar SLIT-ROBO Rho GTPase activating protein 2C (SRGAP2C) locus. The SRGAP2C locus has been shown to encode a protein that functions antagonistically to SLIT-ROBO Rho GTPase activating protein 2 in cortical neuron development. [provided by RefSeq, Dec 2012]
GeneCards Summary for SRGAP2B Gene
SRGAP2B (SLIT-ROBO Rho GTPase Activating Protein 2B) is a Protein Coding gene. An important paralog of this gene is SRGAP3.
UniProtKB/Swiss-Prot for SRGAP2B Gene
May regulate cell migration and differentiation through interaction with and inhibition of SRGAP2.