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Aliases for SRGAP2B Gene

Aliases for SRGAP2B Gene

  • SLIT-ROBO Rho GTPase Activating Protein 2B 2 3 5
  • SLIT-ROBO Rho GTPase Activating Protein 2 Pseudogene 2 2 3 4
  • SLIT-ROBO Rho GTPase Activating Protein 2B (Pseudogene) 2 3
  • SRGAP2P2 3 4
  • SLIT-ROBO Rho GTPase-Activating Protein 2B 3
  • SRGAP2L 3

External Ids for SRGAP2B Gene

Previous HGNC Symbols for SRGAP2B Gene

  • SRGAP2P2

Previous GeneCards Identifiers for SRGAP2B Gene

  • GC01P143915

Summaries for SRGAP2B Gene

Entrez Gene Summary for SRGAP2B Gene

  • This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. This human-specific locus resulted from incomplete segmental duplication of the SLIT-ROBO Rho GTPase activating protein 2 locus. The encoded protein lacks the GTPase activating protein domain compared to proteins encoded by SLIT-ROBO Rho GTPase activating protein 2. The functionality of the protein encoded by this locus has been questioned, as several normal individuals with homozygous deletions for this locus have been identified, and the expression of this locus appears to be much lower than the similar SLIT-ROBO Rho GTPase activating protein 2C (SRGAP2C) locus. The SRGAP2C locus has been shown to encode a protein that functions antagonistically to SLIT-ROBO Rho GTPase activating protein 2 in cortical neuron development. [provided by RefSeq, Dec 2012]

GeneCards Summary for SRGAP2B Gene

SRGAP2B (SLIT-ROBO Rho GTPase Activating Protein 2B) is a Protein Coding gene. An important paralog of this gene is SRGAP2.

UniProtKB/Swiss-Prot for SRGAP2B Gene

  • May regulate cell migration and differentiation through interaction with and inhibition of SRGAP2.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRGAP2B Gene

Genomics for SRGAP2B Gene

Regulatory Elements for SRGAP2B Gene

Enhancers for SRGAP2B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SRGAP2B on UCSC Golden Path with GeneCards custom track

Promoters for SRGAP2B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SRGAP2B Gene

Chromosome:
1
Start:
144,887,191 bp from pter
End:
145,095,528 bp from pter
Size:
208,338 bases
Orientation:
Minus strand

Genomic View for SRGAP2B Gene

Genes around SRGAP2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRGAP2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRGAP2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRGAP2B Gene

Proteins for SRGAP2B Gene

  • Protein details for SRGAP2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DMP2-SRG2B_HUMAN
    Recommended name:
    SLIT-ROBO Rho GTPase-activating protein 2B
    Protein Accession:
    P0DMP2

    Protein attributes for SRGAP2B Gene

    Size:
    458 amino acids
    Molecular mass:
    53406 Da
    Quaternary structure:
    • Homodimer. Interacts with SRGAP2; formation of the heterodimer alters SRGAP2 function (By similarity).
    Miscellaneous:
    • This is one of the 3 duplications of the ancestral gene SRGAP2 which has undergone human-specific segmental gene duplications. The appearance of SRGAP2B in the human genome is estimated to 3,4 million years. Two larger duplications later copied SRGAP2B to chromosome 1p12 (SRGAP2C) and to proximal 1q21.1 (SRGAP2D). SRGAP2B was identified in some individuals but it is not clear if it produces a functional protein (PubMed:22559944).

neXtProt entry for SRGAP2B Gene

Post-translational modifications for SRGAP2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SRGAP2B Gene

No data available for DME Specific Peptides for SRGAP2B Gene

Domains & Families for SRGAP2B Gene

Gene Families for SRGAP2B Gene

Protein Domains for SRGAP2B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P0DMP2

UniProtKB/Swiss-Prot:

SRG2B_HUMAN :
  • Contains 1 F-BAR domain.
Domain:
  • Contains 1 F-BAR domain.
genes like me logo Genes that share domains with SRGAP2B: view

No data available for Suggested Antigen Peptide Sequences for SRGAP2B Gene

Function for SRGAP2B Gene

Molecular function for SRGAP2B Gene

UniProtKB/Swiss-Prot Function:
May regulate cell migration and differentiation through interaction with and inhibition of SRGAP2.

Animal Model Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SRGAP2B Gene

Localization for SRGAP2B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for SRGAP2B Gene

Pathways & Interactions for SRGAP2B Gene

SuperPathways for SRGAP2B Gene

No Data Available

Interacting Proteins for SRGAP2B Gene

Gene Ontology (GO) - Biological Process for SRGAP2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development IEA --
genes like me logo Genes that share ontologies with SRGAP2B: view

No data available for Pathways by source and SIGNOR curated interactions for SRGAP2B Gene

Drugs & Compounds for SRGAP2B Gene

No Compound Related Data Available

Transcripts for SRGAP2B Gene

mRNA/cDNA for SRGAP2B Gene

(12) REFSEQ mRNAs :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRGAP2B Gene

No ASD Table

Relevant External Links for SRGAP2B Gene

GeneLoc Exon Structure for
SRGAP2B
ECgene alternative splicing isoforms for
SRGAP2B

Expression for SRGAP2B Gene

mRNA expression in normal human tissues for SRGAP2B Gene

mRNA differential expression in normal tissues according to GTEx for SRGAP2B Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.4) and Brain - Cerebellum (x4.9).

Protein differential expression in normal tissues from HIPED for SRGAP2B Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SRGAP2B Gene



Protein tissue co-expression partners for SRGAP2B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SRGAP2B Gene:

SRGAP2B
genes like me logo Genes that share expression patterns with SRGAP2B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SRGAP2B Gene

Orthologs for SRGAP2B Gene

Evolution for SRGAP2B Gene

ENSEMBL:
Gene Tree for SRGAP2B (if available)
TreeFam:
Gene Tree for SRGAP2B (if available)

No data available for Orthologs for SRGAP2B Gene

Paralogs for SRGAP2B Gene

genes like me logo Genes that share paralogs with SRGAP2B: view

Variants for SRGAP2B Gene

Sequence variations from dbSNP and Humsavar for SRGAP2B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs492524 -- 144,951,563(-) ttacc(A/C/G)taatt intron-variant
rs493744 -- 145,067,329(-) AGAGA(A/C/G/T)GCCAA intron-variant
rs494511 -- 145,067,281(+) gacag(A/T)gtctt intron-variant
rs494570 -- 145,067,266(-) TGTTG(C/T)CCAGG intron-variant
rs495281 -- 145,006,251(+) ACTGA(A/C/T)GAATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRGAP2B Gene

Variant ID Type Subtype PubMed ID
dgv312n100 CNV gain 25217958
dgv40e214 CNV gain 21293372
esv2516798 CNV gain 19546169
esv2761652 CNV gain 21179565
esv2762186 CNV loss 21179565
esv2830457 CNV duplication 24192839
esv3280050 CNV duplication 24192839
esv3291161 CNV duplication 24192839
esv8055 CNV gain 19470904
nsv1002247 CNV gain+loss 25217958
nsv1003232 CNV gain+loss 25217958
nsv1003402 CNV loss 25217958
nsv1004786 CNV loss 25217958
nsv1010171 CNV gain 25217958
nsv1010181 CNV gain+loss 25217958
nsv1015024 CNV gain 25217958
nsv1075381 CNV duplication 25765185
nsv1118446 CNV duplication 24896259
nsv1118447 CNV duplication 24896259
nsv1128611 CNV duplication 24896259
nsv1136032 CNV deletion 24896259
nsv1139496 CNV duplication 24896259
nsv547651 CNV loss 21841781
nsv7936 CNV loss 18304495
nsv7947 CNV loss 18304495
nsv946222 CNV duplication 23825009
nsv950869 CNV duplication 24416366
nsv954172 CNV deletion 24416366

Relevant External Links for SRGAP2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRGAP2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SRGAP2B Gene

Disorders for SRGAP2B Gene

Relevant External Links for SRGAP2B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRGAP2B

No disorders were found for SRGAP2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRGAP2B Gene

Publications for SRGAP2B Gene

  1. Evolution of human-specific neural SRGAP2 genes by incomplete segmental duplication. (PMID: 22559943) Dennis M.Y. … Eichler E.E. (Cell 2012) 2 3 4 65
  2. Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny during spine maturation. (PMID: 22559944) Charrier C. … Polleux F. (Cell 2012) 2 3 4 65
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 65
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 65

Products for SRGAP2B Gene

Sources for SRGAP2B Gene

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