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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SRGAP2 Gene

protein-coding   GIFtS: 59
GCID: GC01P206516

SLIT-ROBO Rho GTPase activating protein 2

(Previous name: formin binding protein 2 )
(Previous symbol: FNBP2)
 Explore 7 diseases affiliated with
SRGAP2 via
MalaCards
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 Human Malady Compendium 
Biological research products
for SRGAP2    

Aliases
for SRGAP2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
SLIT-ROBO Rho GTPase Activating Protein 21 2     Formin-Binding Protein 22 3
ARHGAP341 2 3     Rho GTPase-Activating Protein 342 3
FNBP21 2 3     SRGAP32
SRGAP2A1 2 3     SLIT-ROBO Rho GTPase-Activating Protein 22
KIAA04561 3 5     SrGAP21
Formin Binding Protein 21 2     

External Ids:    HGNC: 197511   Entrez Gene: 233802   Ensembl: ENSG000001634867   OMIM: 6065245   UniProtKB: O750443   

Export aliases for SRGAP2 gene to outside databases

Previous GC identifers: GC01P205217 GC03M008962 GC03M008997 GC01P202944 GC01P204583 GC01P177269


Summaries
for SRGAP2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SRGAP2:
This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates
GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogous loci on
human chromosome 1, resulting from segmental duplication. While this locus itself is conserved among various species,
the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced
transcript variants have been described for this locus. (provided by RefSeq, Dec 2012)

UniProtKB/Swiss-Prot: SRGP2_HUMAN, O75044
Function: RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to
regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis
and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is
required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the
branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its
interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and
density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In
non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and
filopodia




Genomic Views
for SRGAP2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SRGAP2 gene promoter:
         AhR   GR   GR-beta   FOXD3   Tal-1beta   Arnt   E47   PPAR-alpha   AREB6   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SRGAP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SRGAP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRGAP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.1

SRGAP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRGAP2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P206516:  view genomic region     (about GC identifiers)

Start:
 206,516,196 bp from pter      End:
 206,637,783 bp from pter
Size:
 121,588 bases      Orientation:
 plus strand

Proteins
for SRGAP2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SRGP2_HUMAN, O75044 (See protein sequence)
Recommended Name: SLIT-ROBO Rho GTPase-activating protein 2  
Size: 1071 amino acids; 120881 Da
Subunit: Homodimer (Probable). Forms a heterooligomer with SRGAP1 and SRGAP3 through its F-BAR domain. Interacts (via
SH3 domain) with GPHN (By similarity). Interacts with SRGAP2C; formation of the heterodimer alters SRGAP2 function.
Interacts (via SH3 domain) with FMNL1 (activated by RAC1); regulates the actin filament severing activity of FMNL1 and
actin dynamics. Interacts (via SH3 domain) with FMNL3. Interacts with RAC1; specifically stimulates RAC1 GTPase
activity. Probably interacts with ROBO1 and ROBO2. Interacts with FASLG. Interacts with PRMT5
Subcellular location: Cell membrane. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic cell
membrane, postsynaptic density (By similarity). Cell junction, synapse, postsynaptic cell membrane (By similarity).
Cell projection, lamellipodium. Cytoplasmic vesicle, phagosome (By similarity). Nucleus (By similarity). Cytoplasm (By
similarity). Note=Recruited to actin-rich phagosomes during phagocytosis (By similarity). Translocates from nucleus to
cytoplasm during development (By similarity)
Miscellaneous: There are 3 duplications of SRGAP2 in the human genome as a result of segmental gene duplications.
SRGAP2C is the only one to be fixed at a diploid state in the human genome. Moreover, SRGAP2C is functional, interacts
with and inhibits SRGAP2 and is human-specific. The appearance of SRGAP2C in the human genome is estimated to 2,4
million years ago, which corresponds to the beginning of neocortex expansion in human evolution and it may have played
an important role in this process through its interaction with SRGAP2 function
Sequence caution: Sequence=BAA32301.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for SRGAP2:
2DL8 (3D)    

Explore the universe of human proteins at neXtProt for SRGAP2: NX_O75044

Post-translational modifications:

  • Methylation at Arg-927 is required for the stimulation of cell migration, dimerization and localization at the plasma
    • membrane protrusions1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75044

    • SRGAP2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001164108.1  NP_056141.2  NP_001036223.1  

    ENSEMBL proteins: 
     ENSP00000295713   ENSP00000403036   ENSP00000397004   ENSP00000408089   ENSP00000390898  
     ENSP00000397990  
    Reactome Protein details: O75044
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    Uscn Proteins for SRGAP2

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0005743mitochondrial inner membrane ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IDA--


    SRGAP2 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for SRGAP2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SRGAP2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001060 FCH
     IPR008936 Rho_GTPase_activation_prot
     IPR001452 SH3_domain
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry O75044

    ProtoNet protein and cluster: O75044

    5 Blocks protein families:
    IPB000198 RhoGAP domain
    IPB001060 Cdc15/Fes/CIP4
    IPB001452 SH3 domain signature
    IPB002017 Spectrin repeat
    IPB006121 Heavy metal transport/detoxification protein


    UniProtKB/Swiss-Prot: SRGP2_HUMAN, O75044
    Domain: The F-BAR domain mediates oligomerization, binds membranes, and induces plasma membrane protrusions
    Similarity: Contains 1 FCH domain
    Similarity: Contains 1 Rho-GAP domain
    Similarity: Contains 1 SH3 domain


    Function
    for SRGAP2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SRGP2_HUMAN, O75044
    Function: RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to
    regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis
    and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is
    required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the
    branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its
    interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and
    density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In
    non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and
    filopodia

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    hsa-miR-300 hsa-miR-128 hsa-miR-3122 hsa-miR-1298 hsa-miR-1231 hsa-miR-27a hsa-miR-1267 hsa-miR-1
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    Gene Editing
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    Clone
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0030675Rac GTPase activator activity IMP--
    GO:0042803protein homodimerization activity IDA--
    GO:0048365Rac GTPase binding IDA--


    SRGAP2 for ontologies           About GeneDecksing


    Animal Models:
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Srgap2):
     mortality/aging  nervous system 

    SRGAP2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SRGAP2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Axon guidance
    		Inactivation of Cdc42 and Rac1.00
    		Inactivation of Cdc42 and Rac0.56
    		Axon guidance1.00
    2Axon guidance
    		Axon guidance1.00
    		Developmental Biology0.69
    3Cell death signalling via NRAGE, NRIF and NADE
    		Rho GTPase cycle0.25
    		Signaling by Rho GTPases0.25
    4Signaling by Slit
    		Signaling by Slit1.00
    5Guidance Cues and Growth Cone Motility
    		Guidance Cues and Growth Cone Motility1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SRGAP2
        Guidance Cues and Growth Cone Motility
    Signaling by Slit

    5/9        Reactome Pathways for SRGAP2 (see all 9)
        Signaling by Rho GTPases
    Developmental Biology
    Signaling by Robo receptor
    Rho GTPase cycle
    Inactivation of Cdc42 and Rac


    1         Kegg Pathway  (Kegg details for SRGAP2):
        Axon guidance


    SRGAP2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SRGAP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    5/26 Interacting proteins for SRGAP2 (O750441, 2, 3 ENSP000004080894) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FASLGP480232, 3, ENSP000003566944MINT-7137103 I2D: score=2 STRING: ENSP00000356694
    YWHAGP619812, 3, ENSP000003063304MINT-50874 I2D: score=4 STRING: ENSP00000306330
    YWHAZP631042, 3, ENSP000003095034MINT-3307383 I2D: score=1 STRING: ENSP00000309503
    DISC1Q9NRI53, ENSP000003555964I2D: score=2 STRING: ENSP00000355596
    MYO1GB0I1T23, ENSP000002587874STRING: ENSP00000258787 I2D: score=1 
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003363lamellipodium assembly involved in ameboidal cell migration IMP--
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0007411axon guidance TAS--
    GO:0008283NOT cell proliferation IMP--


    SRGAP2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SRGAP2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Transcripts
    for SRGAP2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SRGAP2 gene (3 alternative transcripts): 
    NM_001170637.2  NM_015326.3  NM_001042758.1  

    Unigene Clusters for SRGAP2:

    SLIT-ROBO Rho GTPase activating protein 2
    Hs.497575  [show with all ESTs], Hs.729527  [show with all ESTs], Hs.744555  [show with all ESTs]
    Unigene Representative Sequences: NM_015326, AK124556, BC150646
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295713(uc001hdy.3 uc010pru.2) ENST00000483628 ENST00000467419(uc009xbt.3)
    ENST00000439126(uc001hdx.3) ENST00000471256 ENST00000426388 ENST00000488049
    ENST00000414359(uc010prt.1 uc010prv.1) ENST00000414007 ENST00000419187


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    hsa-miR-300 hsa-miR-128 hsa-miR-3122 hsa-miR-1298 hsa-miR-1231 hsa-miR-27a hsa-miR-1267 hsa-miR-1
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    Inhib. RNA
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    Additional cDNA sequence: BC150646.1 

    19 DOTS entries:

    DT.313337  DT.97799292  DT.99947749  DT.414555  DT.92037739  DT.121370749  DT.305991  DT.121370798 
    DT.100737737  DT.107435  DT.121435510  DT.412097  DT.100671693  DT.100733276  DT.121370678  DT.121450102 
    DT.92068097  DT.100701209  DT.121435408 

    24/272 AceView cDNA sequences (see all 272):

    AI637971 AA742261 AK000885 AA769137 AI268044 AA761793 AI358988 AA136659 
    F11248 Z41610 BQ774328 AA827731 AI090881 AA155797 BM839483 AI091943 
    BM472244 BQ011731 AI475116 BF059500 BM697885 AI696230 F01655 CA447513 

    GeneLoc Exon Structure


    Expression
    for SRGAP2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SRGAP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGAAGAGAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SRGAP2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Spinal CordSpinal Dorsal ColumnsDorsal Spinal Cord Progenitor CellsSpinal Cord
    BrainCerebral CortexBrain
    Neural TubeTelencephalonNeural Tube
    Spinal CordSpinal Dorsal ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SRGAP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SRGAP2

    SOURCE GeneReport for Unigene clusters: Hs.497575 Hs.729527 Hs.744555
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    In Situ
    Assay Products:     
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    Orthologs
    for SRGAP2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SRGAP2 gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SRGAP21 SLIT-ROBO Rho GTPase activating protein 2 81.61(n)
    94.21(a)    		   419843  XM_417972.3  XP_417972.3 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 73(a)
    		 1 ↔ 1
    		 GL343228.1(1259788-1340986)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.326172 Xenopus laevis transcribed sequence with weak similarity more 74.53(n)    BJ638233.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii srgap2a1 SLIT-ROBO Rho GTPase activating protein 2a 74.03(n)
    78.01(a)    		   556198  NM_001048235.1  NP_001041700.1 
    honey bee
    (Apis mellifera)    		 Insecta --
    --
    		 --
    		 37(a)
    28(a)
    		 many ↔ many
    many ↔ many
    		 GroupUn.6494(193-4365)
    GroupUn.138(27553-37557)
    worm
    (Caenorhabditis elegans)    		 Secernentea srgp-16
    		 Slit-Robo GAP homolog family member (srgp-1)
    		 19(a)
    		 1 → many
    		 IV(11570489-11578689)


    ENSEMBL Gene Tree for SRGAP2 (if available)
    TreeFam Gene Tree for SRGAP2 (if available) 

    Paralogs
    for SRGAP2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SRGAP2 gene
    SRGAP12  ARHGAP52  ARHGAP172  ARHGAP242  ARHGAP222  ARHGAP352  SRGAP32  ARHGAP442  
    SH3BP12  ARHGAP42  ARHGAP252  
    9 SIMAP similar genes for SRGAP2 using alignment to 10 protein entries:     SRGP2_HUMAN (see all proteins):
    SRGAP2C    KIAA1156    SRGAP3    SRGAP1    C1    ARHGAP21
    ARHGAP4    CHN2    ARHGAP12

    SRGAP2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for SRGAP2
    PGOHUM00000244882 PGOHUM00000259585


    Genomic Variants
    for SRGAP2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for SRGAP2
         3 CNVs: 65729 84807 74868
    Human Gene Mutation Database (HGMD): SRGAP2
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SRGAP2
    DNA2.0 Custom Variant and Variant Library Synthesis for SRGAP2

    Disorders / Diseases
    for SRGAP2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SRGAP2 for disorders           About GeneDecksing

    OMIM gene information: 606524    OMIM disorders: --

    UniProtKB/Swiss-Prot: SRGP2_HUMAN, O75044
  • Note=A chromosomal aberration disrupting SRGAP2 has been found in a patient with early infantile epileptic
    • encephalopathy. Balanced translocation t(1;9)(q32;q13)

    7 diseases for SRGAP2:    About MalaCards
    atrioventricular septal defect    pilocytic astrocytoma    astrocytoma    schizophrenia
    neuronitis    infantile epileptic encephalopathy    cerebritis

    1 disease from the University of Copenhagen DISEASES database for SRGAP2:
    Atrioventricular septal defect

    3 Novoseek disease relationships for SRGAP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chondrosarcoma 69.8 1 12736724 (1)
    retinoblastoma 48.5 1 12736724 (1)
    breast cancer 12.3 1 12736724 (1)

    Human Genome Epidemiology (HuGE) Navigator: SRGAP2 (7 documents)

    Export disorders for SRGAP2 gene to outside databases

    Publications
    for SRGAP2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SRGAP2 gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with SRGAP2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway. (PubMed id 11672528)1, 2, 3 Wong K.... Rao Y. (2001)
    2. Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny during spine maturation. (PubMed id 22559944)1, 2 Charrier C....Polleux F. (2012)
    3. Bi-modal regulation of a formin by srGAP2. (PubMed id 21148482)1, 2 Mason F.M....Soderling S.H. (2011)
    4. srGAP2 arginine methylation regulates cell migration and cell spreading through promoting dimerization. (PubMed id 20810653)1, 2 Guo S. and Bao S. (2010)
    5. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924)1, 2 Voss M....Janssen O. (2009)
    6. Changes in mRNA of Slit-Robo GTPase-activating protein 2 following facial nerve transection. (PubMed id 15046868)1, 3 Madura T....Tohyama M. (2004)
    7. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)1, 2 Seki N.... Ohara O. (1997)
    8. FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains. (PubMed id 12736724)1, 9 Katoh M. and Katoh M. (2003)
    9. Evolution of human-specific neural SRGAP2 genes by incomplete segmental duplication. (PubMed id 22559943)1 Dennis M.Y....Eichler E.E. (2012)
    10. The F-BAR domains from srGAP1, srGAP2, and srGAP3 differentially regulate membrane deformation. (PubMed id 22467852)2 Coutinho-Budd J.... Polleux F. (2012)

    External Searches for SRGAP2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SRGAP2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23380 HGNC: 19751 AceView: FNBP2 Ensembl:ENSG00000163486 euGenes: HUgn23380
    ECgene: SRGAP2 Kegg: 23380 H-InvDB: SRGAP2

    Other Databases showing SRGAP2 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0456

    Specialized Databases showing SRGAP2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SRGAP2 Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/sptlt143.shtml

    Intellectual Property
    for SRGAP2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SRGAP2 gene:
    Search GeneIP for patents involving SRGAP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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