SRGAP1 Gene

Aliases
for SRGAP1 gene

Previous GC identifers: GC12P064016 GC12P064330 GC12P062524 GC12P061290

Summaries
for SRGAP1 gene

Genomic Views
for SRGAP1 gene

RefSeq DNA sequence:

NC_000012.11  NC_018923.1  NT_029419.12  

SwitchGear Promoter luciferase reporter plasmid: SRGAP1 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRGAP1

SRGAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P064238:  view genomic region     (about GC identifiers)

Proteins
for SRGAP1 gene

Explore the universe of human proteins at neXtProt for SRGAP1: NX_Q7Z6B7

Post-translational modifications:

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	OriGene Purified Protein: SRGAP1 OriGene Protein Over-expression Lysate: SRGAP1 OriGene Custom Protein Services for SRGAP1
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	Novus Biologicals SRGAP1 Protein Novus Biologicals SRGAP1 Lysates
	Browse Sino Biological Recombinant Proteins
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	Uscn Proteins for SRGAP1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

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	Uscn Antibodies for SRGAP1
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	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
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	GenScript Custom Assay Services for SRGAP1
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	Uscn ELISAs and CLIAs for SRGAP1

Protein Domains /
Families
for SRGAP1 gene

ProtoNet protein and cluster: Q7Z6B7

Function
for SRGAP1 gene

miRNA Products:		miRTarBase miRNAs that target SRGAP1: hsa-mir-214 (MIRT005811), hsa-mir-145 (MIRT005810)
		OriGene 3'-UTR Clone: SRGAP1 Browse MicroRNA Expression Plasmids
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		8/130 QIAGEN miScript miRNA Assays for microRNAs that regulate SRGAP1 (see all 130):
		hsa-miR-3938 hsa-miR-106a hsa-miR-519a hsa-miR-642b hsa-miR-200b hsa-miR-130a* hsa-miR-23c hsa-let-7e
		SwitchGear 3'UTR luciferase reporter plasmid: SRGAP1 3' UTR sequence

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		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SRGAP1 (see all 4) OriGene shRNA RFP: SRGAP1 Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRGAP1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for SRGAP1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRGAP1 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRGAP1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SRGAP1 (NM_020762)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SRGAP1
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRGAP1

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

Pathways & Interactions
for SRGAP1 gene

	Super-pathway	contained gene-specific pathways
1	Axon guidance	Inactivation of Cdc42 and Rac 1.00 Inactivation of Cdc42 and Rac 0.56 Axon guidance 1.00
2	Axon guidance	Axon guidance 1.00 Developmental Biology 0.69
3	Cytoskeleton remodeling Slit-Robo signaling	Cytoskeleton remodeling Slit-Robo signaling 1.00 Development_Slit-Robo signaling 0.92
4	Cell death signalling via NRAGE, NRIF and NADE	Rho GTPase cycle 0.25 Signaling by Rho GTPases 0.25
5	Signaling by Slit	Signaling by Slit 1.00

1 EMD Millipore Pathway for SRGAP1

Cytoskeleton remodeling Slit-Robo signaling

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SRGAP1

	Guidance Cues and Growth Cone Motility
	Signaling by Slit

1 GeneGo (Thomson Reuters) Pathway for SRGAP1

Development Slit-Robo signaling

1 BioSystems Pathway for SRGAP1

Regulation of RhoA activity

5/9        Reactome Pathways for SRGAP1

	Signaling by Rho GTPases
	Developmental Biology
	Signaling by Robo receptor
	Rho GTPase cycle
	Inactivation of Cdc42 and Rac

1         Kegg Pathway  (Kegg details for SRGAP1)

Axon guidance

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

Drugs & Compounds
for SRGAP1 gene

Transcripts
for SRGAP1 gene

Expression
for SRGAP1 gene

SRGAP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACCATTACA

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	KidneyPodocyte LayerPodocytes			Kidney
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SRGAP1 Browse OriGene validated miRNA SYBR primer pairs
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRGAP1

Orthologs
for SRGAP1 gene

Paralogs
for SRGAP1 gene

Paralogs for SRGAP1 gene

ARHGAP5²  ARHGAP17²  ARHGAP24²  ARHGAP22²  SRGAP3²  ARHGAP35²  ARHGAP44²  SH3BP1²  

ARHGAP4²  SRGAP2²  ARHGAP25²  

8 SIMAP similar genes for SRGAP1 using alignment to 3 protein entries:     SRGP1_HUMAN (see all proteins):

KIAA1156    SRGAP2C    SRGAP3    SRGAP2    C1    ARHGAP21

ARHGAP4    ARHGAP12

SRGAP1 for paralogs           About GeneDecksing

Genomic Variants
for SRGAP1 gene

10/4840 NCBI SNPs in SRGAP1 are shown (see all 4840)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1511366291,2	C,	unknown	64417880(+)	CAGAAC/TGGGCA	1	--	int1		0	--	--	--	--
rs356193161,2	C	--	61561741(+)	AAAAA-/AAAAAA	1	--	int1		1		NA	2
rs1177962311,2	F,	--	64236596(+)	ATAGAT/GCTTGT	1	--	us2k1		1		EA	120
rs79587911,2	A	--	64236680(+)	gtgagC/Tggatc	1	--	us2k1 tfbs3		0	--	--	--	--
rs1886593061,2		--	64236991(+)	TTGGAC/TCTTGG	1	--	us2k1		0	--	--	--	--
rs783192511,2	F,	--	64237340(+)	CAAAAG/ACCCCA	1	--	us2k1		3		WA NA EA	358
rs1147643411,2	F,	--	64237361(+)	CGCCAG/CAGCCA	1	--	us2k1		1		WA	118
rs733134791,2	C,	--	64237404(+)	CCTGCC/TGCCGG	1	--	us2k1		5		WA CSA NA EA	361
rs1117085191,2	C,	--	64237425(+)	TCGGCT/CAGCGG	1	--	us2k1		4		CSA WA NA EA	359
rs1813628811,2		--	64237483(+)	GGTGCC/TGGGGG	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for SRGAP1 (64238073 - 64488073 bp, first 250kb of SRGAP1)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 13 variations for SRGAP1
     11 CNVs: 49118 3893 38264 101542 8735 1917 35106 49119 1261 66250 86431
     2 Indels: 11070 60092

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SRGAP1

DNA2.0 Custom Variant and Variant Library Synthesis for SRGAP1

Disorders / Diseases
for SRGAP1 gene

Publications
for SRGAP1 gene

PubMed articles for SRGAP1 gene, integrated from 9 sources (see all 21): (articles sorted by number of sources associating them with SRGAP1)

Utopia: connect your pdf to the dynamic world of online information

1. Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway. (PubMed id 11672528)^{1, 2, 3} Wong K.... Rao Y. (2001)
2. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924)^{1, 2} Voss M....Janssen O. (2009)
3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
5. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)^{1, 2} Nagase T.... Ohara O. (2000)
6. FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains. (PubMed id 12736724)^{1, 9} Katoh M. and Katoh M. (2003)
7. The F-BAR domains from srGAP1, srGAP2, and srGAP3 differentially regulate membrane deformation. (PubMed id 22467852)² Coutinho-Budd J.... Polleux F. (2012)
8. Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
9. The corticofugal neuron-associated genes ROBO1, SRGAP 1, and CTIP2 exhibit an anterior to posterior gradient of expression in early f etal human neocortex development. (PubMed id 21060114)¹ Ip B.K....Clowry G.J. (2011)
10. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)¹ Davila S....Seielstad M. (2010)

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Products
for SRGAP1 gene