Aliases for SRGAP1 Gene
External Ids for SRGAP1 Gene
Previous GeneCards Identifiers for SRGAP1 Gene
GeneCards Summary for SRGAP1 Gene
SRGAP1 (SLIT-ROBO Rho GTPase Activating Protein 1) is a Protein Coding gene. Diseases associated with SRGAP1 include thyroid cancer, nonmedullary, 2. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include GTPase activator activity and Rac GTPase binding. An important paralog of this gene is SRGAP3.
UniProtKB/Swiss-Prot for SRGAP1 Gene
GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.