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Aliases for SRGAP1 Gene

Aliases for SRGAP1 Gene

  • SLIT-ROBO Rho GTPase Activating Protein 1 2 3
  • Rho GTPase-Activating Protein 13 3 4
  • ARHGAP13 3 4
  • KIAA1304 4 6
  • SLIT-ROBO Rho GTPase-Activating Protein 1 3
  • SrGAP1 4

External Ids for SRGAP1 Gene

Previous GeneCards Identifiers for SRGAP1 Gene

  • GC12P064016
  • GC12P064330
  • GC12P062524
  • GC12P061290
  • GC12P064238

Summaries for SRGAP1 Gene

GeneCards Summary for SRGAP1 Gene

SRGAP1 (SLIT-ROBO Rho GTPase Activating Protein 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and L1CAM interactions. GO annotations related to this gene include Rho GTPase binding. An important paralog of this gene is SRGAP3.

UniProtKB/Swiss-Prot for SRGAP1 Gene

  • GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.

Gene Wiki entry for SRGAP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRGAP1 Gene

Genomics for SRGAP1 Gene

Regulatory Elements for SRGAP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SRGAP1 Gene

Start:
63,844,293 bp from pter
End:
64,162,221 bp from pter
Size:
317,929 bases
Orientation:
Plus strand

Genomic View for SRGAP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SRGAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRGAP1 Gene

Proteins for SRGAP1 Gene

  • Protein details for SRGAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z6B7-SRGP1_HUMAN
    Recommended name:
    SLIT-ROBO Rho GTPase-activating protein 1
    Protein Accession:
    Q7Z6B7
    Secondary Accessions:
    • Q9H8A3
    • Q9P2P2

    Protein attributes for SRGAP1 Gene

    Size:
    1085 amino acids
    Molecular mass:
    124264 Da
    Quaternary structure:
    • Homodimer (Probable). Forms a heterooligomer with SRGAP2 and SRGAP3 through its F-BAR domain. Interacts with ROBO1, CDC42 and RHOA. Interacts with FASLG.
    SequenceCaution:
    • Sequence=BAA92542.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA92542.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for SRGAP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRGAP1 Gene

Proteomics data for SRGAP1 Gene at MOPED

Post-translational modifications for SRGAP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SRGAP1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SRGAP1 Gene

Domains for SRGAP1 Gene

Gene Families for SRGAP1 Gene

HGNC:
  • ARHGAP :Rho GTPase activating proteins

Suggested Antigen Peptide Sequences for SRGAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z6B7

UniProtKB/Swiss-Prot:

SRGP1_HUMAN :
  • Q7Z6B7
Domain:
  • The F-BAR domain mediates oligomerization, binds membranes, and constrains plasma membrane protrusions.
  • Contains 1 F-BAR domain.
  • Contains 1 Rho-GAP domain.
  • Contains 1 SH3 domain.
genes like me logo Genes that share domains with SRGAP1: view

Function for SRGAP1 Gene

Molecular function for SRGAP1 Gene

UniProtKB/Swiss-Prot Function: GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.

Gene Ontology (GO) - Molecular Function for SRGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 17500595
GO:0017048 Rho GTPase binding --
GO:0048365 Rac GTPase binding IBA --
genes like me logo Genes that share ontologies with SRGAP1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SRGAP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SRGAP1 Gene

Localization for SRGAP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRGAP1 Gene COMPARTMENTS Subcellular localization image for SRGAP1 gene
Compartment Confidence
cytosol 4
nucleus 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SRGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SRGAP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SRGAP1 Gene

Pathways for SRGAP1 Gene

genes like me logo Genes that share pathways with SRGAP1: view

Pathways by source for SRGAP1 Gene

1 KEGG pathway for SRGAP1 Gene
1 GeneGo (Thomson Reuters) pathway for SRGAP1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat

Gene Ontology (GO) - Biological Process for SRGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007266 Rho protein signal transduction IEA --
GO:0007411 axon guidance TAS --
GO:0016477 cell migration IEA --
genes like me logo Genes that share ontologies with SRGAP1: view

Transcripts for SRGAP1 Gene

Unigene Clusters for SRGAP1 Gene

SLIT-ROBO Rho GTPase activating protein 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SRGAP1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SRGAP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRGAP1 Gene

No ASD Table

Relevant External Links for SRGAP1 Gene

GeneLoc Exon Structure for
SRGAP1
ECgene alternative splicing isoforms for
SRGAP1

Expression for SRGAP1 Gene

mRNA expression in normal human tissues for SRGAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SRGAP1 Gene

SOURCE GeneReport for Unigene cluster for SRGAP1 Gene Hs.210751

mRNA Expression by UniProt/SwissProt for SRGAP1 Gene

Q7Z6B7-SRGP1_HUMAN
Tissue specificity: Expressed in brain, lung, kidney, and testis.
genes like me logo Genes that share expressions with SRGAP1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SRGAP1 Gene

Orthologs for SRGAP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SRGAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRGAP1 35
  • 99.6 (n)
  • 99.82 (a)
SRGAP1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SRGAP1 35
  • 92.63 (n)
  • 98.16 (a)
SRGAP1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRGAP1 35
  • 93.12 (n)
  • 98.99 (a)
SRGAP1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srgap1 35
  • 88.73 (n)
  • 97.97 (a)
Srgap1 16
Srgap1 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SRGAP1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRGAP1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Srgap1 35
  • 88.73 (n)
  • 97.6 (a)
chicken
(Gallus gallus)
Aves SRGAP1 35
  • 83.52 (n)
  • 95.57 (a)
SRGAP1 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRGAP1 36
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9111 35
tropical clawed frog
(Silurana tropicalis)
Amphibia srgap1 35
  • 79.17 (n)
  • 90.69 (a)
zebrafish
(Danio rerio)
Actinopterygii srgap1 35
  • 73.56 (n)
  • 84.93 (a)
srgap1 36
  • 84 (a)
OneToMany
srgap2b 36
  • 70 (a)
OneToMany
zgc63672 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004772 35
  • 50.58 (n)
  • 43.48 (a)
worm
(Caenorhabditis elegans)
Secernentea F12F6.5 37
  • 32 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4983 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToMany
Species with no ortholog for SRGAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRGAP1 Gene

ENSEMBL:
Gene Tree for SRGAP1 (if available)
TreeFam:
Gene Tree for SRGAP1 (if available)

Paralogs for SRGAP1 Gene

Selected SIMAP similar genes for SRGAP1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SRGAP1: view

Variants for SRGAP1 Gene

Sequence variations from dbSNP and Humsavar for SRGAP1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs699627 -- 64,105,372(-) GTACA(C/G)CAGTT intron-variant
rs699628 -- 64,105,599(-) gccac(A/G)ttgtc intron-variant
rs699629 -- 64,127,361(-) AAATA(A/G)TCACC intron-variant
rs699630 -- 64,135,570(-) aggag(G/T)ttagt intron-variant
rs699631 -- 64,135,762(-) aggga(C/T)agaat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRGAP1 Gene

Variant ID Type Subtype PubMed ID
dgv517e1 CNV Complex 17122850
esv2751110 CNV Gain 17911159
nsv832441 CNV Loss 17160897
nsv832442 CNV Gain 17160897
esv2674940 CNV Deletion 23128226
nsv507648 CNV Insertion 20534489
nsv519341 CNV Loss 19592680
esv2745984 CNV Deletion 23290073
esv2577852 CNV Deletion 19546169
nsv747 CNV Loss 18451855
nsv437756 CNV Loss 16327808
esv2656891 CNV Deletion 23128226
nsv498794 CNV Loss 21111241
esv25312 CNV Loss 19812545
nsv515618 CNV Loss 19592680
nsv442274 CNV CNV 18776908
nsv438217 CNV Loss 16468122
esv2673319 CNV Deletion 23128226
esv33314 CNV Loss 17666407

Relevant External Links for SRGAP1 Gene

HapMap Linkage Disequilibrium report
SRGAP1
Human Gene Mutation Database (HGMD)
SRGAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRGAP1 Gene

Disorders for SRGAP1 Gene

Relevant External Links for SRGAP1

Genetic Association Database (GAD)
SRGAP1
Human Genome Epidemiology (HuGE) Navigator
SRGAP1
genes like me logo Genes that share disorders with SRGAP1: view

No data available for UniProtKB/Swiss-Prot for SRGAP1 Gene

Publications for SRGAP1 Gene

  1. Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway. (PMID: 11672528) Wong K. … Rao Y. (Cell 2001) 2 3 4
  2. FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains. (PMID: 12736724) Katoh M. … Katoh M. (Int. J. Mol. Med. 2003) 3 23
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  4. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PMID: 19807924) Voss M. … Janssen O. (BMC Immunol. 2009) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SRGAP1 Gene

Sources for SRGAP1 Gene

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