SRFBP1 Gene
protein-coding GIFtS: 47
GCID: GC05P121327
|
|
Serum Response Factor Binding Protein 1
| |
Aliases
for SRFBP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
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| Aliases |
|---|
| Serum Response Factor Binding Protein 11 2 | | Rlb12 | | p49/STRAP2 3 | | STRAP2 | | SRF-Dependent Transcription Regulation-Associated Protein2 3 | | BUD22 Homolog2 | | P492 5 | | Serum Response Factor-Binding Protein 12 | | BUD22 Homolog (S. Cerevisiae)1 | | SRF-Dependent Transcription Regulation Associated Protein2 | | BUD222 | | |
Export aliases for SRFBP1 gene to outside databasesPrevious GC identifer: GC05P116489 |
Summaries
for SRFBP1 gene(According to Entrez Gene,
GeneCards,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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GeneCards Summary for SRFBP1 Gene:
SRFBP1 (serum response factor binding protein 1) is a protein-coding gene.
UniProtKB/Swiss-Prot: SRFB1_HUMAN, Q8NEF9Function: May be involved in regulating transcriptional activation of cardiac genes during the aging process. May
play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity)
|
Genomic Views
for SRFBP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 75),
Regulatory elements and Epigenetics data according to
QIAGEN, and/or
SwitchGear Genomics)
About This Section
TryGeneCards Plus | RefSeq DNA sequence:- NC_000005.10 NC_018916.2 NT_034772.7
Regulatory elements:
 Regulatory transcription factor binding sites in the SRFBP1 gene promoter:
USF1 RFX1 USF-1 FOXD3 Nkx2-5 MRF-2 Hlf
Other transcription factors
Search Chromatin IP Primers for SRFBP1
Epigenetics:
| | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SRFBP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q23.1 Ensembl cytogenetic band: 5q23.1 HGNC cytogenetic band: 5q23.1SRFBP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P121327: view genomic region
(about GC identifiers)
Start:
|
121,297,656 bp from pter |
End:
|
121,411,265 bp from pter |
Size:
|
113,610 bases |
Orientation:
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plus strand |
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Proteins
for SRFBP1 gene
(According to
1UniProtKB,
HORDE,
2neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Antibodies by
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SRFB1_HUMAN, Q8NEF9 (See
protein sequence)Recommended Name: Serum response factor-binding protein 1 Size: 429 amino acids; 48634 Da
Subunit: Interacts with SRF. Forms complexes with SRF and SRF cofactors ARID2, MYOCD and NKX2-5. Interacts with
the N-terminus of SLC2A4 (By similarity)
Developmental stage: Up-regulated in adult heart (at protein level)
Sequence caution: Sequence=BAB71631.1; Type=Frameshift; Positions=425;
Secondary accessions: Q5QFI2 Q96AH4 Q96DK2Explore the universe of human proteins at neXtProt for SRFBP1: NX_Q8NEF9
Explore proteomics data for SRFBP1 at MOPED
Post-translational modifications:  Modification sites at neXtProt Modification sites at PhosphoSitePlus
See SRFBP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB
REFSEQ proteins: NP_689759.2
ENSEMBL proteins: ENSP00000341324
SRFBP1 Human Recombinant
Protein Products:SRFBP1 Antibody
Products:SRFBP1 Assay Products: |
Domains /
Families
for SRFBP1 gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
TryGeneCards Plus | 1 InterPro protein domain:Graphical View of Domain Structure for InterPro Entry Q8NEF9 ProtoNet protein and cluster: Q8NEF9
SRFBP1 for domains About GeneDecksing
|
Function
for SRFBP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
transcription factor targeting from QIAGEN
and/or HOMER,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
SwitchGear Genomics,
Gene Editing from DNA2.0,
Clones from OriGene,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
ESI BIO,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Molecular Function:
UniProtKB/Swiss-Prot Summary: SRFB1_HUMAN, Q8NEF9Function: May be involved in regulating transcriptional activation of cardiac genes during the aging process. May
play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity) Gene Ontology (GO): 2 molecular function terms: About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
-- | -- | | GO:0044822 | poly(A) RNA binding |
IDA | -- |
SRFBP1 for ontologies About GeneDecksing
Animal Models:
Inhib. RNA
Products: |  | OriGene RNAi products in human, mouse, rat for SRFBP1
| | | Predesigned siRNA for gene silencing in human, mouse, rat SRFBP1 |
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for SRFBP1 | |  | Browse ESI BIO Cell Lines and PureStem Progenitors for SRFBP1  | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRFBP1 |
Localization
for SRFBP1 gene
(According to UniProtKB, COMPARTMENTS Subcellular localization database,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot SRFB1_HUMAN, Q8NEF9: Cytoplasm, perinuclear region (By similarity)Subcellular locations from COMPARTMENTS:
| Compartment | Confidence |
|---|
|
| nucleus | 3 | | cytosol | 2 |
Gene Ontology (GO): 2 cellular component terms: About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- | | GO:0048471 | perinuclear region of cytoplasm |
IEA | -- |
SRFBP1 for ontologies About GeneDecksing
|
Pathways & Interactions
for SRFBP1 gene
(SuperPaths according to PathCards,
Pathways according to
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
QIAGEN,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene).
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Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SRFBP1
Interactions:
Search GeneGlobe Interaction Network for SRFBP1
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
Selected Interacting proteins for SRFBP1 (Q8NEF93 ENSP000003413244) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
Gene Ontology (GO): 2 biological process terms: About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-templated |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-templated |
IEA | -- |
SRFBP1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SRFBP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience,
ApexBio,
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB)
About This Section
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 Browse compounds at ApexBio
 Browse Tocris compounds for SRFBP1 (SRFB1)
|
Transcripts
for SRFBP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
SwitchGear Genomics,
Tagged/untagged cDNA clones from
OriGene,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene, and/or
QIAGEN
)
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REFSEQ mRNAs for SRFBP1 gene: NM_152546.2 Unigene Cluster for SRFBP1: Serum response factor binding protein 1 Hs.107622 [show with all ESTs]Unigene Representative Sequence: NM_1525462 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000339397(uc003kst.1) ENST00000504881
Inhib. RNA
Products: | | OriGene RNAi products in human, mouse, rat for SRFBP1
| |
| | Predesigned siRNA for gene silencing in human, mouse, rat SRFBP1 |
Primer
Products: | | OriGene qPCR primer pairs and template standards for SRFBP1
OriGene qSTAR qPCR primer pairs in human, mouse for SRFBP1
| | | Pre-validated RT2 qPCR Primer Assay in human, mouse / rat SRFBP1 | | | QuantiTect SYBR Green Assays in human, mouse, rat SRFBP1 | | | QuantiFast Probe-based Assays in human, mouse, rat SRFBP1 |
Additional mRNA sequence: AK058015.1 AY611630.2 BC017102.1 BC031222.1 4 DOTS entries: DT.408792 DT.40231999 DT.92022780 DT.92420159 Selected AceView cDNA sequences (see all 52): AI932947 BQ650816 BP343187 BU631303 BQ233077 H25304 AI391443 BC017102 BX102622 AL698020 BG679126 C04913 AL710701 W21298 AK058015 AW044451 CB960501 BG661272 CD518580 NM_152546 AL709382 BQ082032 BG943734 BC031222
GeneLoc Exon Structure
|
Expression
for SRFBP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MaxQB,
plus additional links to
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
QIAGEN,
Primers from
OriGene, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SRFBP1 expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TACTTTTTGA
About this image SRFBP1 Protein expression data from MOPED1, PaxDb2 and
MaxQB3: About this image
SOURCE GeneReport for Unigene cluster: Hs.107622
UniProtKB/Swiss-Prot: SRFB1_HUMAN, Q8NEF9Tissue specificity: Abundantly expressed in heart and skeletal muscle, and at much lower levels in brain and lung
Custom PCR Arrays for SRFBP1
Primer
Products: | | OriGene qPCR primer pairs and template standards for SRFBP1
OriGene qSTAR qPCR primer pairs in human, mouse for SRFBP1
| | | Pre-validated RT2 qPCR Primer Assay in human, mouse / rat SRFBP1 | | | QuantiTect SYBR Green Assays in human, mouse, rat SRFBP1 | | | QuantiFast Probe-based Assays in human, mouse, rat SRFBP1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRFBP1 |
Orthologs
for SRFBP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
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This gene was present in the common ancestor of chordates.
Orthologs for SRFBP1 gene from Selected species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Srfbp11 , 5 |
serum response factor binding protein 11, 5 |
73.04(n)1
67.13(a)1 |
|
18 (28.21 cM)5
672221 NM_026040.31 NP_080316.31
524656935 |
chicken
(Gallus gallus) |
Aves |
SRFBP11 |
serum response factor binding protein 1 |
59.24(n)
50.5(a) |
|
426795 XM_424408.4 XP_424408.2 |
lizard
(Anolis carolinensis) |
Reptilia |
SRFBP16 |
serum response factor binding protein 1 |
43(a) |
1 ↔ 1 |
GL343193.1(11672801-11725911) |
African clawed frog
(Xenopus laevis) |
Amphibia |
flj25286-prov2 |
hypothetical protein MGC68879 |
75.9(n) |
|
BC055988.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufc54c062 |
Danio rerio mRNA similar to hypothetical protein FLJ25286 more |
81.96(n) |
|
BC050494.1 |
ENSEMBL Gene Tree for SRFBP1 (if available)
TreeFam Gene Tree for SRFBP1 (if available) |
Paralogs
for SRFBP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
TryGeneCards Plus | Paralogs for SRFBP1 gene
SRFBP1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for SRFBP1
PGOHUM00000235740
|
Genomic Variants
for SRFBP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD), the Human Cytochrome P450 Allele
Nomenclature Database, and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SRFBP1 (121297656 - 121411265 bp)
Structural Variations
Database of Genomic Variants (DGV) 3 variations for SRFBP1: About this table
| | Site Specific Mutation Identification with PCR Assays |
| | SeqTarget long-range PCR primers for resequencing SRFBP1 |
|
Disorders
/ Diseases
for SRFBP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
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OMIM gene information: 610479
OMIM disorders: --
SRFBP1 for disorders About GeneDecksing
Genetic Association Database (GAD): SRFBP1
Export disorders for SRFBP1 gene to outside databases
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Publications
for SRFBP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for SRFBP1 gene, integrated from 10 sources (see all 19):
(articles sorted by number of sources associating them with SRFBP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a novel serum response factor cofactor in cardiac gene regulation. (PubMed id 15492011)1, 2, 3, 9 Zhang X.... Wei J.Y. (J. Biol. Chem. 2004)
- Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
- Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
- N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
- A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
- Interaction of Hsp70 with p49/STRAP, a serum response factor binding protein. (PubMed id 19751705)1 Lin J.L....Wang C. (Biochem. Biophys. Res. Commun. 2009)
- Identification of a subunit of NADH-dehydrogenase as a p49/STRAP-binding protein. (PubMed id 18230186)1 Zhang X....Wei J.Y. (BMC Cell Biol. 2008)
|
External Searches for SRFBP1 gene (in PubMed,
OMIM, and NCBI Bookshelf)
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|
Genome Databases showing SRFBP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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|
Other Databases showing SRFBP1 gene
(According to HUGE)
About This Section
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Specialized Databases showing SRFBP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for SRFBP1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
TryGeneCards Plus | Patent Information for SRFBP1 gene:
Search GeneIP for patents involving SRFBP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SRFBP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or
ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
About This Section
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 | |
 |
| | | | |
 |
 |
|  | Block miRNA regulation of human, mouse, rat SRFBP1 using miScript Target Protectors | | SeqTarget long-range PCR primers for resequencing SRFBP1 | | | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SRFBP1 | | Predesigned siRNA for gene silencing in human, mouse, rat SRFBP1 | | | QuantiFast Probe-based Assays in human, mouse, rat SRFBP1 | | QuantiTect SYBR Green Assays in human, mouse, rat SRFBP1 | | | Custom PCR Arrays for SRFBP1 | | Search Chromatin IP Primers for SRFBP1 | | | Pre-validated RT2 qPCR Primer Assay in human, mouse / rat SRFBP1 | | Search GeneGlobe Interaction Network for SRFBP1 | | | Regulatory tfbs in SRFBP1 promoter |
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 |
 |
 |  | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRFBP1 |
| |  |  |  |  | | | ThermoFisher Antibodies for SRFBP1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRFBP1 |
| | | | LSBio Antibodies in human, mouse, rat for SRFBP1 |
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