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Aliases for SRFBP1 Gene

Aliases for SRFBP1 Gene

  • Serum Response Factor Binding Protein 1 2 3 5
  • SRF-Dependent Transcription Regulation-Associated Protein 3 4
  • P49/STRAP 3 4
  • Serum Response Factor-Binding Protein 1 3
  • BUD22 Homolog (S. Cerevisiae) 2
  • BUD22 Homolog 3
  • BUD22 3
  • STRAP 3
  • Rlb1 3
  • P49 3

External Ids for SRFBP1 Gene

Previous GeneCards Identifiers for SRFBP1 Gene

  • GC05P121327
  • GC05P116489

Summaries for SRFBP1 Gene

GeneCards Summary for SRFBP1 Gene

SRFBP1 (Serum Response Factor Binding Protein 1) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for SRFBP1 Gene

  • May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRFBP1 Gene

Genomics for SRFBP1 Gene

Regulatory Elements for SRFBP1 Gene

Enhancers for SRFBP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G122696 1.4 Ensembl ENCODE dbSUPER 22.4 +735.1 735101 1.0 ZNF493 ZFP64 ZNF121 ZNF138 ZNF354C KLF7 ZNF202 ZNF654 SP3 ZNF680 SNX2 ENSG00000260686 SRFBP1 ZNF474 LOX KRT8P33 PRDM6 ARGFXP1 GC05M122721
GH05G122180 1.6 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +220.3 220332 4.4 KLF1 JUN MAX FEZF1 ZFHX2 ZNF316 GATA2 SCRT2 FOS PRDM10 LOX ENSG00000247311 ENSG00000249610 ENSG00000250803 SRFBP1 PIR45845
GH05G122773 1.4 ENCODE dbSUPER 11.1 +813.8 813791 4.0 HDGF FOXA2 PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SNX2 LOX SRFBP1 ENSG00000260686 PRDM6 PPIC RN7SL689P
GH05G122089 1.4 FANTOM5 ENCODE dbSUPER 10.8 +127.9 127878 1.5 CBX3 ATF1 CREB3L1 ARNT CHAMP1 TCF12 CBX5 GATA2 SCRT2 FOS SRFBP1 ENSG00000250803 ENSG00000247311 ENSG00000249610 LOX ZNF474
GH05G122098 1.3 Ensembl ENCODE dbSUPER 11.3 +137.2 137188 1.1 JUN FOSL1 ZNF316 GATA2 EGR1 NR2F6 NFE2 FOS CREM MAFK SRFBP1 LOX ZNF474
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SRFBP1 on UCSC Golden Path with GeneCards custom track

Promoters for SRFBP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000185903 239 2001 MLX DMAP1 YY1 ZNF143 SP3 TBX21 ZNF610 NBN NR2C1 KDM1A

Genomic Location for SRFBP1 Gene

Chromosome:
5
Start:
121,961,961 bp from pter
End:
122,075,570 bp from pter
Size:
113,610 bases
Orientation:
Plus strand

Genomic View for SRFBP1 Gene

Genes around SRFBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRFBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRFBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRFBP1 Gene

Proteins for SRFBP1 Gene

  • Protein details for SRFBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEF9-SRFB1_HUMAN
    Recommended name:
    Serum response factor-binding protein 1
    Protein Accession:
    Q8NEF9
    Secondary Accessions:
    • Q5QFI2
    • Q96AH4
    • Q96DK2

    Protein attributes for SRFBP1 Gene

    Size:
    429 amino acids
    Molecular mass:
    48634 Da
    Quaternary structure:
    • Interacts with SRF. Forms complexes with SRF and SRF cofactors ARID2, MYOCD and NKX2-5. Interacts with the N-terminus of SLC2A4 (By similarity).
    SequenceCaution:
    • Sequence=BAB71631.1; Type=Frameshift; Positions=425; Evidence={ECO:0000305};

neXtProt entry for SRFBP1 Gene

Post-translational modifications for SRFBP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SRFBP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SRFBP1 Gene

Domains & Families for SRFBP1 Gene

Protein Domains for SRFBP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SRFBP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SRFBP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SRFBP1 Gene

Function for SRFBP1 Gene

Molecular function for SRFBP1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity).

Gene Ontology (GO) - Molecular Function for SRFBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SRFBP1: view
genes like me logo Genes that share phenotypes with SRFBP1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SRFBP1 Gene

Localization for SRFBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRFBP1 Gene

Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRFBP1 gene
Compartment Confidence
nucleus 5
plasma membrane 2
cytosol 2

Gene Ontology (GO) - Cellular Components for SRFBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
GO:0005737 cytoplasm IEA --
GO:0030686 90S preribosome IBA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with SRFBP1: view

Pathways & Interactions for SRFBP1 Gene

SuperPathways for SRFBP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SRFBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0030490 maturation of SSU-rRNA IBA --
genes like me logo Genes that share ontologies with SRFBP1: view

No data available for Pathways by source and SIGNOR curated interactions for SRFBP1 Gene

Transcripts for SRFBP1 Gene

mRNA/cDNA for SRFBP1 Gene

Unigene Clusters for SRFBP1 Gene

Serum response factor binding protein 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRFBP1 Gene

No ASD Table

Relevant External Links for SRFBP1 Gene

GeneLoc Exon Structure for
SRFBP1
ECgene alternative splicing isoforms for
SRFBP1

Expression for SRFBP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SRFBP1 Gene

Protein differential expression in normal tissues from HIPED for SRFBP1 Gene

This gene is overexpressed in Retina (24.3), Lung (20.6), Testis (9.2), and Pancreatic juice (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SRFBP1 Gene



Protein tissue co-expression partners for SRFBP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SRFBP1 Gene:

SRFBP1

SOURCE GeneReport for Unigene cluster for SRFBP1 Gene:

Hs.107622

mRNA Expression by UniProt/SwissProt for SRFBP1 Gene:

Q8NEF9-SRFB1_HUMAN
Tissue specificity: Abundantly expressed in heart and skeletal muscle, and at much lower levels in brain and lung.

Evidence on tissue expression from TISSUES for SRFBP1 Gene

  • Liver(4.2)
genes like me logo Genes that share expression patterns with SRFBP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRFBP1 Gene

Orthologs for SRFBP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SRFBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRFBP1 34 35
  • 98.91 (n)
dog
(Canis familiaris)
Mammalia SRFBP1 34 35
  • 85.25 (n)
cow
(Bos Taurus)
Mammalia SRFBP1 34 35
  • 85.05 (n)
rat
(Rattus norvegicus)
Mammalia Srfbp1 34
  • 74.44 (n)
mouse
(Mus musculus)
Mammalia Srfbp1 34 16 35
  • 73.04 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 59 (a)
OneToMany
-- 35
  • 47 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SRFBP1 35
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves SRFBP1 34 35
  • 59.24 (n)
lizard
(Anolis carolinensis)
Reptilia SRFBP1 35
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia srfbp1 34
  • 60.74 (n)
Str.7448 34
African clawed frog
(Xenopus laevis)
Amphibia flj25286-prov 34
zebrafish
(Danio rerio)
Actinopterygii srfbp1 34 35
  • 51.19 (n)
wufc54c06 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6565 35
  • 21 (a)
OneToOne
Species where no ortholog for SRFBP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SRFBP1 Gene

ENSEMBL:
Gene Tree for SRFBP1 (if available)
TreeFam:
Gene Tree for SRFBP1 (if available)

Paralogs for SRFBP1 Gene

Pseudogenes.org Pseudogenes for SRFBP1 Gene

genes like me logo Genes that share paralogs with SRFBP1: view

No data available for Paralogs for SRFBP1 Gene

Variants for SRFBP1 Gene

Sequence variations from dbSNP and Humsavar for SRFBP1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs876657852 Pathogenic 122,074,155(-) CAGTA(G/T)GGATG intron-variant, reference, missense
rs886040965 Pathogenic 122,075,443(-) ACCCA(G/T)CCGAC reference, missense, utr-variant-3-prime, utr-variant-5-prime
rs886040967 Pathogenic 122,075,482(-) TCCCC(A/C)AAGAG reference, missense, utr-variant-3-prime, utr-variant-5-prime
rs1000006036 -- 122,013,043(+) TGTAA(C/T)AAAGA intron-variant
rs1000011531 -- 122,049,480(+) AAAGT(C/T)AACAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRFBP1 Gene

Variant ID Type Subtype PubMed ID
esv2672222 CNV deletion 23128226
esv3606583 CNV loss 21293372
nsv1110448 CNV duplication 24896259
nsv433233 CNV loss 18776910
nsv599647 CNV gain 21841781

Variation tolerance for SRFBP1 Gene

Residual Variation Intolerance Score: 90% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.22; 62.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRFBP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRFBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRFBP1 Gene

Disorders for SRFBP1 Gene

Relevant External Links for SRFBP1

Genetic Association Database (GAD)
SRFBP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRFBP1

No disorders were found for SRFBP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRFBP1 Gene

Publications for SRFBP1 Gene

  1. Identification of a novel serum response factor cofactor in cardiac gene regulation. (PMID: 15492011) Zhang X. … Wei J.Y. (J. Biol. Chem. 2004) 2 3 4 22 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  4. Quantitative Proteomics Identifies Serum Response Factor Binding Protein 1 as a Host Factor for Hepatitis C Virus Entry. (PMID: 26212323) Gerold G. … Pietschmann T. (Cell Rep 2015) 3 64
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64

Products for SRFBP1 Gene

Sources for SRFBP1 Gene

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