SRFBP1 Gene
protein-coding GIFtS: 43
GCID: GC05P121327
|
|
serum response factor binding protein 1
| |
Aliases
for SRFBP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Serum Response Factor Binding Protein 11 2 | | P492 5 | | BUD221 2 | | FLJ252861 | | Rlb11 2 | | P492 5 | | STRAP1 2 | | BUD22 Homolog2 | | P49/STRAP1 | | Serum Response Factor-Binding Protein 12 | | SRF-Dependent Transcription Regulation-Associated Protein2 3 | | SRF-Dependent Transcription Regulation Associated Protein2 |
Export aliases for SRFBP1 gene to outside databasesPrevious GC identifer: GC05P116489 |
Summaries
for SRFBP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SRFB1_HUMAN, Q8NEF9Function: May be involved in regulating transcriptional activation of cardiac genes during the aging process. May playa role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity)
|
Genomic Views
for SRFBP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_034772.6
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SRFBP1 gene promoter:
USF1 RFX1 USF-1 FOXD3 Nkx2-5 MRF-2 Hlf
Other transcription factors
Search SABiosciences Chromatin IP Primers for SRFBP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRFBP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q23.1 Ensembl cytogenetic band: 5q23.1 HGNC cytogenetic band: 5q23.1SRFBP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P121327: view genomic region
(about GC identifiers)
Start:
|
121,297,656 bp from pter |
End:
|
121,411,265 bp from pter |
Size:
|
113,610 bases |
Orientation:
|
plus strand |
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Proteins
for SRFBP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SRFB1_HUMAN, Q8NEF9 (See
protein sequence)Recommended Name: Serum response factor-binding protein 1 Size: 429 amino acids; 48634 Da
Subunit: Interacts with SRF. Forms complexes with SRF and SRF cofactors ARID2, MYOCD and NKX2-5. Interacts with theN-terminus of SLC2A4 (By similarity)
Subcellular location: Cytoplasm, perinuclear region (By similarity)
Developmental stage: Up-regulated in adult heart (at protein level)
Sequence caution: Sequence=BAB71631.1; Type=Frameshift; Positions=425;
Secondary accessions: Q5QFI2 Q96AH4 Q96DK2Explore the universe of human proteins at neXtProt for SRFBP1: NX_Q8NEF9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NEF9
SRFBP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689759.2
ENSEMBL proteins: ENSP00000341324
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- | | GO:0048471 | perinuclear region of cytoplasm |
IEA | -- |
SRFBP1 for ontologies About GeneDecksing
SRFBP1 Antibody Products:
Assay Products for SRFBP1: |
Protein
Domains /
Families
for SRFBP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SRFBP1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8NEF9ProtoNet protein and cluster: Q8NEF9 |
Function
for SRFBP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SRFB1_HUMAN, Q8NEF9Function: May be involved in regulating transcriptional activation of cardiac genes during the aging process. May playa role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRFBP1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRFBP1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRFBP1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
-- | -- |
SRFBP1 for ontologies About GeneDecksing
|
Pathways & Interactions
for SRFBP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SRFBP1
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
5/10 Interacting proteins for SRFBP1 (Q8NEF93 ENSP000003413244) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
SRFBP1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SRFBP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SRFBP1
Search CenterWatch for drugs/clinical trials and news about SRFBP1 / SRFB1
|
Transcripts
for SRFBP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SRFBP1 gene: NM_152546.2 Unigene Cluster for SRFBP1: Serum response factor binding protein 1 Hs.107622 [show with all ESTs]Unigene Representative Sequence: NM_1525462 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000339397(uc003kst.1) ENST00000504881
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRFBP1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRFBP1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SRFBP1 (NM_152546) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SRFBP1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRFBP1 |
Additional cDNA sequence: AK058015.1 AY611630.2 BC017102.1 BC031222.1 4 DOTS entries: DT.408792 DT.40231999 DT.92022780 DT.92420159 24/52 AceView cDNA sequences (see all 52): AI932947 BC017102 BP343187 BU631303 BQ650816 AI391443 BQ233077 H25304 BQ082032 CD518580 BG679126 C04913 BG193119 AL709382 BG943734 BC031222 C15253 BG681071 CD521931 AK058015 BX102622 AW044451 BU169530 CB960501
GeneLoc Exon Structure
|
Expression
for SRFBP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SRFBP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACTTTTTGA
About this image
See SRFBP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SRFBP1
SOURCE GeneReport for Unigene cluster: Hs.107622
UniProtKB/Swiss-Prot: SRFB1_HUMAN, Q8NEF9Tissue specificity: Abundantly expressed in heart and skeletal muscle, and at much lower levels in brain and lung
SABiosciences Custom PCR Arrays for SRFBP1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SRFBP1
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRFBP1 |
Orthologs
for SRFBP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SRFBP1 gene from 7/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Srfbp11 , 5 |
serum response factor binding protein 11, 5 |
73.04(n)1
67.13(a)1 |
|
18 (28.21 cM)5
672221 NM_026040.31 NP_080316.31
524656935 |
chicken
(Gallus gallus) |
Aves |
SRFBP11 |
serum response factor binding protein 1 |
58.37(n)
48.55(a) |
|
426795 XM_424408.3 XP_424408.2 |
lizard
(Anolis carolinensis) |
Reptilia |
SRFBP16 |
-- |
42(a) |
1 ↔ 1 |
GL343193.1(11697278-11725911) |
African clawed frog
(Xenopus laevis) |
Amphibia |
flj25286-prov2 |
hypothetical protein MGC68879 |
75.9(n) |
|
BC055988.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufc54c062 |
Danio rerio mRNA similar to hypothetical protein FLJ25286 more |
81.96(n) |
|
BC050494.1 |
honey bee
(Apis mellifera) |
Insecta |
-- |
-- |
23(a) |
1 ↔ 1 |
Group6.37(24564-25973) |
worm
(Caenorhabditis elegans) |
Secernentea |
F18C12.36 |
-- |
14(a) |
1 ↔ 1 |
I(8095735-8098437) |
ENSEMBL Gene Tree for SRFBP1 (if available)
TreeFam Gene Tree for SRFBP1 (if available) |
Paralogs
for SRFBP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SRFBP1 gene
SRFBP1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for SRFBP1
PGOHUM00000235740
|
Genomic Variants
for SRFBP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SRFBP1 (121297656 - 121411265 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SRFBP1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SRFBP1 |
|
Disorders
/ Diseases
for SRFBP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 SRFBP1 for disorders About MalaCards
SRFBP1 for disorders About GeneDecksing
OMIM gene information: 610479
OMIM disorders: --
Export disorders for SRFBP1 gene to outside databases
|
Publications
for SRFBP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SRFBP1 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with SRFBP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a novel serum response factor cofactor in cardiac gene regulation. (PubMed id 15492011)1, 2, 3, 9 Zhang X.... Wei J.Y. (2004)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Interaction of Hsp70 with p49/STRAP, a serum response factor binding protein. (PubMed id 19751705)1 Lin J.L....Wang C. (2009)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Identification of a subunit of NADH-dehydrogenase as a p49/STRAP-binding protein. (PubMed id 18230186)1 Zhang X....Wei J.Y. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)2 Olsen J.V....Mann M. (2006)
|
External Searches for SRFBP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SRFBP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SRFBP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SRFBP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SRFBP1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SRFBP1 gene:
Search GeneIP for patents involving SRFBP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SRFBP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SRFBP1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SRFBP1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRFBP1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRFBP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRFBP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRFBP1 |
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 | | | SRFBP1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRFBP1 |
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