Aliases for SRFBP1 Gene
Aliases for SRFBP1 Gene
External Ids for SRFBP1 Gene
- HGNC: 26333
- Entrez Gene: 153443
- Ensembl: ENSG00000151304
- OMIM: 610479
- UniProtKB: Q8NEF9
Previous GeneCards Identifiers for SRFBP1 Gene
- GC05P121327
- GC05P116489
Summaries for SRFBP1 Gene
GeneCards Summary for SRFBP1 Gene
SRFBP1 (Serum Response Factor Binding Protein 1) is a Protein Coding gene.
UniProtKB/Swiss-Prot for SRFBP1 Gene
-
May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity).
Additional gene information for SRFBP1 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRFBP1 Gene
Genomics for SRFBP1 Gene
GeneHancer (GH) Regulatory Elements for SRFBP1 Gene
Promoters and enhancers for SRFBP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around SRFBP1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for SRFBP1 Gene
Genomic Locations for SRFBP1 Gene
- chr5:121,961,961-122,075,570
- (GRCh38/hg38)
- Size:
- 113,610 bases
- Orientation:
- Plus strand
- chr5:121,297,656-121,411,265
- (GRCh37/hg19)
Genomic View for SRFBP1 Gene
Genes around SRFBP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q23.1 by Ensembl
- 5q23.1 by Entrez Gene
- 5q23.1 by HGNC
SRFBP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SRFBP1 Gene
Proteins for SRFBP1 Gene
-
Protein details for SRFBP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NEF9-SRFB1_HUMAN
- Recommended name:
- Serum response factor-binding protein 1
- Protein Accession:
- Q8NEF9
- Q5QFI2
- Q96AH4
- Q96DK2
Protein attributes for SRFBP1 Gene
- Size:
- 429 amino acids
- Molecular mass:
- 48634 Da
- Quaternary structure:
-
- Interacts with SRF. Forms complexes with SRF and SRF cofactors ARID2, MYOCD and NKX2-5. Interacts with the N-terminus of SLC2A4 (By similarity).
- SequenceCaution:
-
- Sequence=BAB71631.1; Type=Frameshift; Positions=425; Evidence={ECO:0000305};
Protein Expression for SRFBP1 Gene
Post-translational modifications for SRFBP1 Gene
No Post-translational modifications
Other Protein References for SRFBP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for SRFBP1
-
Abcam antibodies for SRFBP1
- Invitrogen Antibodies for SRFBP1
- Search GeneTex for Antibodies for SRFBP1
- Sino Biological Antibodies for SRFBP1
Protein Products
-
OriGene Purified Proteins for SRFBP1
- Search Origene for MassSpec and Protein Over-expression Lysates for SRFBP1
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- Sino Biological Cell Lysates for SRFBP1
- Sino Biological Recombinant Proteins for SRFBP1
- antibodies-online: Search results for 5 available SRFBP1 Proteins ranked by validation data
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-
Quality Products:
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-
Abcam proteins for SRFBP1
Assay Products
- antibodies-online: Search results for 4 available SRFBP1 Elisa Kits ranked by validation data
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-
Quality Products:
No data available for DME Specific Peptides for SRFBP1 Gene
Domains & Families for SRFBP1 Gene
Gene Families for SRFBP1 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for SRFBP1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for SRFBP1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for SRFBP1 Gene
Function for SRFBP1 Gene
Molecular function for SRFBP1 Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | HDA | 22658674 |
Phenotypes for SRFBP1 Gene
- GenomeRNAi human phenotypes for SRFBP1:
-
- Increased vaccinia virus (VACV) infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Decreased NF-kappaB reporter expression
- Weakly decreased NFAT1-GFP nuclear translocation
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for SRFBP1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SRFBP1 gene
- Search ViGene Biosciences for SRFBP1
CRISPR Products
-
OriGene CRISPR knockouts for SRFBP1
- genomics-online: gRNA clones - Search results for available SRFBP1 gene related products
- Applied Biological Materials CRISPR for SRFBP1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SRFBP1
- GenScript: Design CRISPR guide RNA sequences for SRFBP1
miRNA for SRFBP1 Gene
- miRTarBase miRNAs that target SRFBP1
-
- hsa-mir-2054 (MIRT560669)
- hsa-mir-8068 (MIRT560670)
- hsa-mir-92b-3p (MIRT560671)
- hsa-mir-92a-3p (MIRT560672)
- hsa-mir-367-3p (MIRT560673)
- hsa-mir-363-3p (MIRT560674)
- hsa-mir-32-5p (MIRT560675)
- hsa-mir-25-3p (MIRT560676)
- hsa-mir-302f (MIRT560677)
- hsa-mir-8066 (MIRT560678)
- hsa-mir-5692a (MIRT560679)
- hsa-mir-4668-5p (MIRT619737)
- hsa-mir-3613-3p (MIRT619738)
- hsa-mir-4735-5p (MIRT619739)
- hsa-mir-6877-3p (MIRT619740)
- hsa-mir-6819-3p (MIRT619741)
- hsa-mir-7109-3p (MIRT619742)
- hsa-mir-129-5p (MIRT626181)
- hsa-mir-8055 (MIRT626182)
- hsa-mir-6864-3p (MIRT626183)
- hsa-mir-3672 (MIRT626184)
- hsa-mir-4524a-3p (MIRT626185)
- hsa-mir-1-5p (MIRT626186)
- hsa-mir-3664-5p (MIRT626187)
- hsa-mir-514a-5p (MIRT626188)
- hsa-mir-4714-5p (MIRT626189)
miRNA Products
- Search ViGene Biosciences for SRFBP1
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SRFBP1
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-
ViGene Biosciences ready-to-package AAV shRNAs for SRFBP1 gene
Clone Products
- Sino Biological Human cDNA Clone for SRFBP1
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- VectorBuilder custom plasmid, inducible vectors for SRFBP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SRFBP1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available SRFBP1 gene related products
- orf clones - Search results for available SRFBP1 gene related products
- Applied Biological Materials Clones for SRFBP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for SRFBP1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SRFBP1 gene
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ViGene Biosciences ready-to-package AAV shRNAs for SRFBP1 gene
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SRFBP1 Gene
Localization for SRFBP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SRFBP1 Gene
- Cytoplasm, perinuclear region.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 2 |
| cytosol | 2 |
- Nucleoli fibrillar center (3)
- Nucleus (3)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IBA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0030686 | 90S preribosome | IBA | -- |
| GO:0048471 | perinuclear region of cytoplasm | IEA | -- |
Pathways & Interactions for SRFBP1 Gene
No Data Available
Interacting Proteins for SRFBP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0030490 | maturation of SSU-rRNA | IBA | -- |
No data available for Pathways by source and SIGNOR curated interactions for SRFBP1 Gene
Transcripts for SRFBP1 Gene
mRNA/cDNA for SRFBP1 Gene
- (2) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (52) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SRFBP1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SRFBP1
- genomics-online: gRNA clones - Search results for available SRFBP1 gene related products
- Applied Biological Materials CRISPR for SRFBP1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SRFBP1
- GenScript: Design CRISPR guide RNA sequences for SRFBP1
miRNA Products
- Search ViGene Biosciences for SRFBP1
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SRFBP1
- Browse OriGene Inhibitory RNA Products For SRFBP1
- genomics-online: shRNA clones - Search results for available SRFBP1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SRFBP1 gene
Clone Products
- Sino Biological Human cDNA Clone for SRFBP1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SRFBP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SRFBP1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available SRFBP1 gene related products
- orf clones - Search results for available SRFBP1 gene related products
- Applied Biological Materials Clones for SRFBP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for SRFBP1 Gene
This gene is overexpressed in Retina (24.3), Lung (20.6), Testis (9.2), and Pancreatic juice (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SRFBP1 Gene
NURSA nuclear receptor signaling pathways regulating expression of SRFBP1 Gene:
SRFBP1SOURCE GeneReport for Unigene cluster for SRFBP1 Gene:
Hs.107622mRNA Expression by UniProt/SwissProt for SRFBP1 Gene:
Q8NEF9-SRFB1_HUMAN
Tissue specificity:
Abundantly expressed in heart and skeletal muscle, and at much lower levels in brain and lung.
Evidence on tissue expression from TISSUES for SRFBP1 Gene
- Liver(4.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for SRFBP1
-
OriGene qPCR primer pairs for SRFBP1
- genomics-online: primer clones - Search results for available SRFBP1 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRFBP1 Gene
Orthologs for SRFBP1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SRFBP1 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | SRFBP1 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | SRFBP1 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Srfbp1 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Srfbp1 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | SRFBP1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | SRFBP1 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | SRFBP1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | srfbp1 33 |
|
||
| Str.7448 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | flj25286-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | srfbp1 33 34 |
|
||
| wufc54c06 33 |
|
||||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.6565 34 |
|
OneToOne |
- Species where no ortholog for SRFBP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for SRFBP1 Gene
Pseudogenes.org Pseudogenes for SRFBP1 Gene
No data available for Paralogs for SRFBP1 Gene
Variants for SRFBP1 Gene
| SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs876657852 | uncertain-significance, pathogenic, not specified, Aortic aneurysm, familial thoracic 10 | 122,074,155(+) | A/C | genic_downstream_transcript_variant, intron_variant | |
| rs886040965 | pathogenic, Aortic aneurysm, familial thoracic 10 | 122,075,443(+) | C/A | 3_prime_UTR_variant, genic_downstream_transcript_variant | |
| rs886040967 | pathogenic, Aortic aneurysm, familial thoracic 10 | 122,075,482(+) | T/G | 3_prime_UTR_variant, genic_downstream_transcript_variant | |
| rs1064796814 | likely-pathogenic, not provided | 122,070,488(+) | CTTTACCTTTA/CTTTA | genic_downstream_transcript_variant, intron_variant | |
| rs1000006036 | -- | 122,013,043(+) | T/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2672222 | CNV | deletion | 23128226 |
| esv3606583 | CNV | loss | 21293372 |
| nsv1110448 | CNV | duplication | 24896259 |
| nsv433233 | CNV | loss | 18776910 |
| nsv599647 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
90% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.22;
62.12% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SRFBP1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SRFBP1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRFBP1 Gene
Disorders for SRFBP1 Gene
Additional Disease Information for SRFBP1
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for SRFBP1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRFBP1 Gene
Publications for SRFBP1 Gene
- Identification of a novel serum response factor cofactor in cardiac gene regulation. (PMID: 15492011) Zhang X … Wei JY (The Journal of biological chemistry 2004) 2 3 4 22 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
- Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. (PMID: 27880917) St-Denis N … Gingras AC (Cell reports 2016) 3 58
- Does p49/STRAP, a SRF-binding protein (SRFBP1), modulate cardiac mitochondrial function in aging? (PMID: 27337995) Zhang X … Wei JY (Experimental gerontology 2016) 3 58
Products for SRFBP1 Gene
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- Invitrogen Antibodies for SRFBP1
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- VectorBuilder custom plasmid, inducible vectors for SRFBP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SRFBP1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 34 available SRFBP1 Antibodies ranked by validation data
- Compare Top SRFBP1 Antibodies
- antibodies-online: Search results for 4 available SRFBP1 Elisa Kits ranked by validation data
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- Quality Products:
- antibodies-online: Search results for 5 available SRFBP1 Proteins ranked by validation data
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- Quality Products:
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- ViGene Biosciences adenoviral particle packaged cDNA for SRFBP1 gene
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- genomics-online: cdna clones - Search results for available SRFBP1 gene related products
- orf clones - Search results for available SRFBP1 gene related products
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Sources for SRFBP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
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