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Aliases for SRFBP1 Gene

Aliases for SRFBP1 Gene

  • Serum Response Factor Binding Protein 1 2 3
  • SRF-Dependent Transcription Regulation-Associated Protein 3 4
  • P49/STRAP 3 4
  • P49 3 6
  • SRF-Dependent Transcription Regulation Associated Protein 3
  • Serum Response Factor-Binding Protein 1 3
  • BUD22 Homolog (S. Cerevisiae) 2
  • BUD22 Homolog 3
  • BUD22 3
  • STRAP 3
  • Rlb1 3

External Ids for SRFBP1 Gene

Summaries for SRFBP1 Gene

GeneCards Summary for SRFBP1 Gene

SRFBP1 (Serum Response Factor Binding Protein 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease.

UniProtKB/Swiss-Prot for SRFBP1 Gene

  • May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRFBP1 Gene

Genomics for SRFBP1 Gene

Genomic Location for SRFBP1 Gene

Start:
121,961,961 bp from pter
End:
122,075,570 bp from pter
Size:
113,610 bases
Orientation:
Plus strand

Genomic View for SRFBP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SRFBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRFBP1 Gene

Regulatory Elements for SRFBP1 Gene

Proteins for SRFBP1 Gene

  • Protein details for SRFBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEF9-SRFB1_HUMAN
    Recommended name:
    Serum response factor-binding protein 1
    Protein Accession:
    Q8NEF9
    Secondary Accessions:
    • Q5QFI2
    • Q96AH4
    • Q96DK2

    Protein attributes for SRFBP1 Gene

    Size:
    429 amino acids
    Molecular mass:
    48634 Da
    Quaternary structure:
    • Interacts with SRF. Forms complexes with SRF and SRF cofactors ARID2, MYOCD and NKX2-5. Interacts with the N-terminus of SLC2A4 (By similarity).
    SequenceCaution:
    • Sequence=BAB71631.1; Type=Frameshift; Positions=425; Evidence={ECO:0000305};

neXtProt entry for SRFBP1 Gene

Proteomics data for SRFBP1 Gene at MOPED

Post-translational modifications for SRFBP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SRFBP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SRFBP1 Gene

Domains for SRFBP1 Gene

Protein Domains for SRFBP1 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with SRFBP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SRFBP1 Gene

Function for SRFBP1 Gene

Molecular function for SRFBP1 Gene

UniProtKB/Swiss-Prot Function: May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity).

Gene Ontology (GO) - Molecular Function for SRFBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SRFBP1: view

miRNA for SRFBP1 Gene

miRTarBase miRNAs that target SRFBP1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SRFBP1 Gene

Localization for SRFBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRFBP1 Gene

Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRFBP1 Gene COMPARTMENTS Subcellular localization image for SRFBP1 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for SRFBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm --
GO:0030686 90S preribosome IBA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with SRFBP1: view

Pathways for SRFBP1 Gene

genes like me logo Genes that share pathways with SRFBP1: view

Pathways by source for SRFBP1 Gene

Interacting Proteins for SRFBP1 Gene

Gene Ontology (GO) - Biological Process for SRFBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0030490 maturation of SSU-rRNA IBA --
genes like me logo Genes that share ontologies with SRFBP1: view

Transcripts for SRFBP1 Gene

mRNA/cDNA for SRFBP1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(52) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SRFBP1 Gene

Serum response factor binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SRFBP1 Gene

No ASD Table

Relevant External Links for SRFBP1 Gene

GeneLoc Exon Structure for
SRFBP1
ECgene alternative splicing isoforms for
SRFBP1

Expression for SRFBP1 Gene

mRNA expression in normal human tissues for SRFBP1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SRFBP1 Gene

SOURCE GeneReport for Unigene cluster for SRFBP1 Gene Hs.107622

mRNA Expression by UniProt/SwissProt for SRFBP1 Gene

Q8NEF9-SRFB1_HUMAN
Tissue specificity: Abundantly expressed in heart and skeletal muscle, and at much lower levels in brain and lung.
genes like me logo Genes that share expressions with SRFBP1: view

Orthologs for SRFBP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SRFBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRFBP1 36
  • 98.91 (n)
  • 97.9 (a)
SRFBP1 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SRFBP1 36
  • 85.05 (n)
  • 76.64 (a)
SRFBP1 37
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRFBP1 36
  • 85.25 (n)
  • 78.92 (a)
SRFBP1 37
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srfbp1 36
  • 73.04 (n)
  • 67.13 (a)
Srfbp1 16
Srfbp1 37
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 47 (a)
OneToMany
-- 37
  • 59 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SRFBP1 37
  • 48 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Srfbp1 36
  • 74.44 (n)
  • 67.83 (a)
chicken
(Gallus gallus)
Aves SRFBP1 36
  • 59.24 (n)
  • 50.5 (a)
SRFBP1 37
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRFBP1 37
  • 43 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia flj25286-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia srfbp1 36
  • 60.74 (n)
  • 56.38 (a)
Str.7448 36
zebrafish
(Danio rerio)
Actinopterygii srfbp1 36
  • 51.19 (n)
  • 42.14 (a)
srfbp1 37
  • 23 (a)
OneToOne
wufc54c06 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6565 37
  • 21 (a)
OneToOne
Species with no ortholog for SRFBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SRFBP1 Gene

ENSEMBL:
Gene Tree for SRFBP1 (if available)
TreeFam:
Gene Tree for SRFBP1 (if available)

Paralogs for SRFBP1 Gene

Pseudogenes.org Pseudogenes for SRFBP1 Gene

genes like me logo Genes that share paralogs with SRFBP1: view

No data available for Paralogs for SRFBP1 Gene

Variants for SRFBP1 Gene

Sequence variations from dbSNP and Humsavar for SRFBP1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs840468 -- 122,015,931(-) AAGTA(C/T)ATGAG intron-variant
rs1142708 -- 122,027,262(+) ctcaa(G/T)tgatc utr-variant-3-prime
rs2042877 -- 121,987,371(-) TTTTT(C/T)CCAAA intron-variant
rs2042878 -- 121,986,779(-) aaata(C/T)cacta intron-variant
rs2399729 -- 121,966,786(-) aaaaa(A/T)aaaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRFBP1 Gene

Variant ID Type Subtype PubMed ID
nsv882814 CNV Loss 21882294
nsv433233 CNV Loss 18776910
esv2672222 CNV Deletion 23128226

Relevant External Links for SRFBP1 Gene

HapMap Linkage Disequilibrium report
SRFBP1

Disorders for SRFBP1 Gene

Relevant External Links for SRFBP1

Genetic Association Database (GAD)
SRFBP1
genes like me logo Genes that share disorders with SRFBP1: view

No data available for UniProtKB/Swiss-Prot for SRFBP1 Gene

Publications for SRFBP1 Gene

  1. Identification of a novel serum response factor cofactor in cardiac gene regulation. (PMID: 15492011) Zhang X. … Wei J.Y. (J. Biol. Chem. 2004) 2 3 4 23
  2. Heterogeneity of ternary complex factors in HeLa cell nuclear extracts. (PMID: 8083237) Pingoud V. … Nordheim A. (J. Biol. Chem. 1994) 3
  3. Creation of genome-wide protein expression libraries using random activation of gene expression. (PMID: 11329013) Harrington J.J. … Ducar M. (Nat. Biotechnol. 2001) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Identification and characterization of p49/STRAP as a novel GLUT4- binding protein. (PMID: 16647043) Lisinski I. … Al-Hasani H. (Biochem. Biophys. Res. Commun. 2006) 3

Products for SRFBP1 Gene

Sources for SRFBP1 Gene

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