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SRFBP1 Gene

protein-coding   GIFtS: 47
GCID: GC05P121327

Serum Response Factor Binding Protein 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serum Response Factor Binding Protein 11 2     Rlb12
p49/STRAP2 3     STRAP2
SRF-Dependent Transcription Regulation-Associated Protein2 3     BUD22 Homolog2
P492 5     Serum Response Factor-Binding Protein 12
BUD22 Homolog (S. Cerevisiae)1     SRF-Dependent Transcription Regulation Associated Protein2
BUD222     

External Ids:    HGNC: 263331   Entrez Gene: 1534432   Ensembl: ENSG000001513047   OMIM: 6104795   UniProtKB: Q8NEF93   

Export aliases for SRFBP1 gene to outside databases

Previous GC identifer: GC05P116489


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SRFBP1 Gene:
SRFBP1 (serum response factor binding protein 1) is a protein-coding gene.

UniProtKB/Swiss-Prot: SRFB1_HUMAN, Q8NEF9
Function: May be involved in regulating transcriptional activation of cardiac genes during the aging process. May
play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the SRFBP1 gene promoter:
         USF1   RFX1   USF-1   FOXD3   Nkx2-5   MRF-2   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSRFBP1 promoter sequence
   Search Chromatin IP Primers for SRFBP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SRFBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23.1   Ensembl cytogenetic band:  5q23.1   HGNC cytogenetic band: 5q23.1

SRFBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRFBP1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P121327:  view genomic region     (about GC identifiers)

Start:
121,297,656 bp from pter      End:
121,411,265 bp from pter
Size:
113,610 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SRFB1_HUMAN, Q8NEF9 (See protein sequence)
Recommended Name: Serum response factor-binding protein 1  
Size: 429 amino acids; 48634 Da
Subunit: Interacts with SRF. Forms complexes with SRF and SRF cofactors ARID2, MYOCD and NKX2-5. Interacts with
the N-terminus of SLC2A4 (By similarity)
Developmental stage: Up-regulated in adult heart (at protein level)
Sequence caution: Sequence=BAB71631.1; Type=Frameshift; Positions=425;
Secondary accessions: Q5QFI2 Q96AH4 Q96DK2

Explore the universe of human proteins at neXtProt for SRFBP1: NX_Q8NEF9

Explore proteomics data for SRFBP1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SRFBP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689759.2  
    ENSEMBL proteins: 
     ENSP00000341324  

    SRFBP1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR015158 Bud-site_select_BUD22

    Graphical View of Domain Structure for InterPro Entry Q8NEF9

    ProtoNet protein and cluster: Q8NEF9


    Find genes that share domains with SRFBP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRFB1_HUMAN, Q8NEF9
    Function: May be involved in regulating transcriptional activation of cardiac genes during the aging process. May
    play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with SRFBP1           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SRFBP1
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    miRNA
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    miRTarBase miRNAs that target SRFBP1:
    hsa-mir-374b-5p (MIRT036801), hsa-mir-16-5p (MIRT031678), hsa-mir-34a-5p (MIRT025462)

    Block miRNA regulation of human, mouse, rat SRFBP1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate SRFBP1:
    hsa-miR-433 hsa-miR-3161 hsa-miR-494 hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidSRFBP1 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SRFB1_HUMAN, Q8NEF9: Cytoplasm, perinuclear region (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0048471perinuclear region of cytoplasm IEA--

    Find genes that share ontologies with SRFBP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SRFBP1
    Interactions:

        Search GeneGlobe Interaction Network for SRFBP1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    Selected Interacting proteins for SRFBP1 (Q8NEF93 ENSP000003413244) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC2A4P146723, ENSP000003209354I2D: score=1 STRING: ENSP00000320935
    SRFP118313, ENSP000002653544I2D: score=1 STRING: ENSP00000265354
    CDC42P609533I2D: score=2 
    MAPK9P459843I2D: score=2 
    MEF2CQ064133I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with SRFBP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SRFBP1 (SRFB1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SRFBP1 gene: 
    NM_152546.2  

    Unigene Cluster for SRFBP1:

    Serum response factor binding protein 1
    Hs.107622  [show with all ESTs]
    Unigene Representative Sequence: NM_152546
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000339397(uc003kst.1) ENST00000504881
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate SRFBP1:
    hsa-miR-433 hsa-miR-3161 hsa-miR-494 hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidSRFBP1 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat SRFBP1
      QuantiFast Probe-based Assays in human, mouse, rat SRFBP1

    Additional mRNA sequence: 

    AK058015.1 AY611630.2 BC017102.1 BC031222.1 

    4 DOTS entries:

    DT.408792  DT.40231999  DT.92022780  DT.92420159 

    Selected AceView cDNA sequences (see all 52):

    AI932947 BQ650816 BP343187 BU631303 BQ233077 H25304 AI391443 BC017102 
    BX102622 AL698020 BG679126 C04913 AL710701 W21298 AK058015 AW044451 
    CB960501 BG661272 CD518580 NM_152546 AL709382 BQ082032 BG943734 BC031222 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SRFBP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACTTTTTGA
    SRFBP1 Expression
    About this image

    SRFBP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SRFBP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.107622

    UniProtKB/Swiss-Prot: SRFB1_HUMAN, Q8NEF9
    Tissue specificity: Abundantly expressed in heart and skeletal muscle, and at much lower levels in brain and lung

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SRFBP1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srfbp11 , 5 serum response factor binding protein 11, 5 73.04(n)1
    67.13(a)1
      18 (28.21 cM)5
    672221  NM_026040.31  NP_080316.31 
     524656935 
    chicken
    (Gallus gallus)
    Aves SRFBP11 serum response factor binding protein 1 59.24(n)
    50.5(a)
      426795  XM_424408.4  XP_424408.2 
    lizard
    (Anolis carolinensis)
    Reptilia SRFBP16
    serum response factor binding protein 1
    43(a)
    1 ↔ 1
    GL343193.1(11672801-11725911)
    African clawed frog
    (Xenopus laevis)
    Amphibia flj25286-prov2 hypothetical protein MGC68879 75.9(n)    BC055988.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc54c062 Danio rerio mRNA similar to hypothetical protein FLJ25286 more 81.96(n)    BC050494.1 


    ENSEMBL Gene Tree for SRFBP1 (if available)
    TreeFam Gene Tree for SRFBP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SRFBP1 gene

    Find genes that share paralogs with SRFBP1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SRFBP1
    PGOHUM00000235740


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SRFBP1 (see all 1497)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1826277141,2
    --121295656(+) ATTACA/TATTCA 1 -- us2k10--------
    rs1380581301,2
    --121295696(+) TTCATA/GTAACA 1 -- us2k10--------
    rs117464871,2
    C,F,H--121295837(+) GGGTTC/TTGGAC 1 -- us2k18Minor allele frequency- T:0.01NS EA NA 846
    rs1435807151,2
    C--121295960(+) GTCTAA/GTGGGA 1 -- us2k10--------
    rs1472216821,2
    --121296045(+) TCTCTA/GGTTTC 1 -- us2k10--------
    rs1912263391,2
    --121296146(+) TTTGAA/GGGTCT 1 -- us2k10--------
    rs1388954991,2
    --121296172(+) TGTCTC/GTGTGC 1 -- us2k10--------
    rs1427105301,2
    C--121296321(+) ACCTCC/TGCCTC 1 -- us2k10--------
    rs1444573961,2
    C--121296322(+) CCTCCA/GCCTCC 1 -- us2k10--------
    rs1828199151,2
    --121296392(+) CACCAC/TGGTCG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SRFBP1 (121297656 - 121411265 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SRFBP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2672222CNV Deletion23128226
    nsv882814CNV Loss21882294
    nsv433233CNV Loss18776910

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610479    OMIM disorders: --


    Find genes that share disorders with SRFBP1           About GenesLikeMe

    Genetic Association Database (GAD): SRFBP1

    Export disorders for SRFBP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SRFBP1 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with SRFBP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel serum response factor cofactor in cardiac gene regulation. (PubMed id 15492011)1, 2, 3, 9 Zhang X.... Wei J.Y. (J. Biol. Chem. 2004)
    2. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    3. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    4. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    6. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    7. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    8. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    9. Interaction of Hsp70 with p49/STRAP, a serum response factor binding protein. (PubMed id 19751705)1 Lin J.L....Wang C. (Biochem. Biophys. Res. Commun. 2009)
    10. Identification of a subunit of NADH-dehydrogenase as a p49/STRAP-binding protein. (PubMed id 18230186)1 Zhang X....Wei J.Y. (BMC Cell Biol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 153443 HGNC: 26333 AceView: FLJ25286 Ensembl:ENSG00000151304 euGenes: HUgn153443
    ECgene: SRFBP1 H-InvDB: SRFBP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SRFBP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SRFBP1 gene:
    Search GeneIP for patents involving SRFBP1

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    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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