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SRF Gene

protein-coding   GIFtS: 62
GCID: GC06P043138

Serum Response Factor (C-Fos Serum Response Element-Binding...

  See SRF-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serum Response Factor (C-Fos Serum Response Element-Binding
Transcription Factor)1 2
MCM12
Serum Response Factor2

External Ids:    HGNC: 112911   Entrez Gene: 67222   Ensembl: ENSG000001126587   OMIM: 6005895   UniProtKB: P118313   

Export aliases for SRF gene to outside databases

Previous GC identifers: GC06P043141 GC06P043185 GC06P043247 GC06P042855


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SRF Gene:
This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is
a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein
binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the
activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation,
apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for
example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors
(TCFs). (provided by RefSeq, Jul 2008)

GeneCards Summary for SRF Gene:
SRF (serum response factor (c-fos serum response element-binding transcription factor)) is a protein-coding gene. Diseases associated with SRF include rheumatoid nodulosis, and miller fisher syndrome. GO annotations related to this gene include transcription factor binding and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: SRF_HUMAN, P11831
Function: SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad
symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Required
for cardiac differentiation and maturation

Gene Wiki entry for SRF (Serum response factor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the SRF gene promoter:
         SRF   SRF (504 AA)   MyoD   Nkx2-5   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSRF promoter sequence
   Search Chromatin IP Primers for SRF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SRF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p

SRF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRF gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P043138:  view genomic region     (about GC identifiers)

Start:
43,138,920 bp from pter      End:
43,149,244 bp from pter
Size:
10,325 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SRF_HUMAN, P11831 (See protein sequence)
Recommended Name: Serum response factor  
Size: 508 amino acids; 51593 Da
Subunit: Binds DNA as a multimer, probably a dimer. Interacts with MLLT7/FOXO4, NKX3A and SSRP1. Interacts with
ARID2 and SRFBP1 (By similarity). Forms complexes with ARID2, MYOCD, NKX2-5 and SRFBP1 (By similarity). Forms a
nuclear ternary complex with MKL1 and SCAI. Interacts with LPXN
3 PDB 3D structures from and Proteopedia for SRF:
1HBX (3D)        1K6O (3D)        1SRS (3D)    
Secondary accessions: Q5T648

Explore the universe of human proteins at neXtProt for SRF: NX_P11831

Explore proteomics data for SRF at MOPED

Post-translational modifications: 

  • Phosphorylated by PRKDC1
  • Glycosylation2 at Ser277, Ser307, Ser309, Ser316, Ser383
  • Modification sites at PhosphoSitePlus

  • See SRF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003122.1  
    ENSEMBL proteins: 
     ENSP00000265354   ENSP00000401320  

    SRF Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SRF
    OriGene Protein Over-expression Lysate for SRF
    OriGene MassSpec for SRF
    OriGene Custom Protein Services for SRF
    GenScript Custom Purified and Recombinant Proteins Services for SRF
    Novus Biologicals SRF Protein
    Novus Biologicals SRF Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SRF

     
    Search eBioscience for Proteins for SRF 

     
    antibodies-online proteins for SRF (6 products) 

     
    antibodies-online peptides for SRF

    SRF Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SRF
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    Cell Signaling Technology (CST) Antibodies for SRF 
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    Novus Biologicals SRF Antibodies
    Abcam antibodies for SRF
    Cloud-Clone Corp. Antibodies for SRF
    ThermoFisher Antibodies for SRF
    antibodies-online antibodies for SRF (114 products) 

    SRF Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SRF
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SRF
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SRF
    Cloud-Clone Corp. CLIAs for SRF
    Search eBioscience for ELISAs for SRF 
    antibodies-online kits for SRF (9 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR002100 TF_MADSbox

    Graphical View of Domain Structure for InterPro Entry P11831

    ProtoNet protein and cluster: P11831

    1 Blocks protein domain: IPB002100 Transcription factor

    UniProtKB/Swiss-Prot: SRF_HUMAN, P11831
    Similarity: Contains 1 MADS-box domain


    Find genes that share domains with SRF           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRF_HUMAN, P11831
    Function: SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad
    symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Required
    for cardiac differentiation and maturation

         Gene Ontology (GO): Selected molecular function terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding ISS--
    GO:0000983contributes to RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity IMP18296735
    GO:0001076RNA polymerase II transcription factor binding transcription factor activity IEA--
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA--
    GO:0001228RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription ISS--
         
    Find genes that share ontologies with SRF           About GenesLikeMe


    Phenotypes:
         14 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Srf):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  muscle 
     no phenotypic analysis  normal  respiratory system  skeleton 

    Find genes that share phenotypes with SRF           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for SRF: Srftm1Nor Srftm2.2Nor Srftm2.3Nor

       genOway: Develop your customized and physiologically relevant rodent model for SRF

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for SRF (see all 896):
    A2ML1,  AATK,  ABCA13,  ABCC5,  ABCD1,  ABCG5,  ABCG8,  ABHD12,  ABLIM1,  ABRA

    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  CCATATATGGNA 

    miRNA
    Products:
        
    miRTarBase miRNAs that target SRF:
    hsa-mir-92a-3p (MIRT049829), hsa-mir-26b-5p (MIRT028897), hsa-mir-331-3p (MIRT043424), hsa-mir-1 (MIRT023547), hsa-mir-122-5p (MIRT000365), hsa-mir-484 (MIRT041943), hsa-mir-18a-3p (MIRT040918), hsa-mir-324-3p (MIRT042926), hsa-mir-320a (MIRT044832)

    Block miRNA regulation of human, mouse, rat SRF using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SRF (see all 81):
    hsa-miR-642a hsa-miR-371-5p hsa-miR-550a* hsa-miR-877* hsa-miR-149 hsa-miR-376c hsa-miR-200b hsa-miR-564
    SwitchGear 3'UTR luciferase reporter plasmidSRF 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SRF
    Predesigned siRNA for gene silencing in human, mouse, rat SRF

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SRF

    Clone
    Products:
         
    OriGene clones in human, mouse for SRF (see all 6)
    OriGene ORF clones in mouse, rat for SRF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SRF (NM_003131)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRF
    Addgene plasmids for SRF 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for SRF
    Browse ESI BIO Cell Lines and PureStem Progenitors for SRF 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRF


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SRF_HUMAN, P11831: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton3
    extracellular2
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin IEA--
    GO:0005634nucleus IDA2108863
    GO:0005737cytoplasm TAS15180964

    Find genes that share ontologies with SRF           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SRF About   (see all 32)  
    See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2NGF Pathway
    TRKA Signaling0.75
    NGF Pathway0.75
    3TCR Signaling (Qiagen)
    TCR Signaling0.68
    PDGF Pathway0.39
    4ErbB4 Pathway
    Growth Hormone Signaling0.49
    LPS Stimulated MAPK Signaling0.47
    5PEDF Induced Signaling
    PEDF Induced Signaling0.73


    Find genes that share SuperPaths with SRF           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SRF (see all 15)
        Chemokine Signaling
    TRKA Signaling
    Cellular Transformation by HTLV1
    PDGF Pathway
    Signaling Involved in Cardiac Hypertrophy

    2 Cell Signaling Technology (CST) Pathways for SRF
        MAP Kinase Signaling
    Cytoskeletal Signaling

    2 GeneGo (Thomson Reuters) Pathways for SRF
        Immune response IL-6 signaling pathway
    Development PDGF signaling via MAPK cascades

    Selected BioSystems Pathways for SRF (see all 14)
        MAPK signaling pathway
    Heart Development
    Insulin Signaling
    Serotonin Receptor 4/6/7 and NR3C Signaling
    Serotonin Receptor 2 and ELK-SRF/GATA4 signaling


    3 Kegg Pathways  (Kegg details for SRF):
        MAPK signaling pathway
    HTLV-I infection
    Viral carcinogenesis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SRF: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              Synaptic Plasticity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SRF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SRF (P118311, 2, 3 ENSP000002653544) via UniProtKB, MINT, STRING, and/or I2D (see all 274)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYOD1P151722, 3, ENSP000002500034MINT-15522 MINT-15523 I2D: score=2 STRING: ENSP00000250003
    MKL2Q9ULH71, 3, ENSP000003390864EBI-493034,EBI-493007 I2D: score=3 STRING: ENSP00000339086
    MYOGP151732, 3, ENSP000002416514MINT-16345 MINT-16346 I2D: score=4 STRING: ENSP00000241651
    MYOCDQ8IZQ81, 3, ENSP000003418354EBI-493034,EBI-493384 I2D: score=4 STRING: ENSP00000341835
    MKL1Q969V61, 3, ENSP000003478474EBI-493034,EBI-493122 I2D: score=4 STRING: ENSP00000347847
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 69):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001569patterning of blood vessels IEA--
    GO:0001666response to hypoxia IEP19098903
    GO:0001701in utero embryonic development ----
    GO:0001707mesoderm formation IEA--
    GO:0001764neuron migration IEA--

    Find genes that share ontologies with SRF           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SRF

    Selected Novoseek inferred chemical compound relationships for SRF gene (see all 95)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mdi-a 60.5 6 11509578 (1), 20071339 (1), 12429848 (1)
    jasplakinolide 51.2 6 17332502 (1), 11502570 (1), 19874818 (1), 15240009 (1)
    ganglioside gq1b 47.4 1 9753137 (1)
    phosphatidylinositol 28.6 3 1939110 (1), 11342553 (1), 11859076 (1)
    cyclic amp 26.2 10 7507831 (1), 9658126 (1), 10342376 (1), 10961986 (1) (see all 8)
    il-12 22 1 9462175 (1)
    mannose 21.1 2 1846001 (1), 9815228 (1)
    thymidine 21 2 8535215 (1), 12704643 (1)
    12-o-tetradecanoylphorbol 13-acetate 14.7 6 1656100 (1), 11980664 (1), 9880563 (1)
    polysulfone 14.5 2 8675359 (1)



    Find genes that share compounds with SRF           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SRF gene: 
    NM_003131.2  

    Unigene Cluster for SRF:

    Serum response factor (c-fos serum response element-binding transcription factor)
    Hs.520140  [show with all ESTs]
    Unigene Representative Sequence: AB209128
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265354(uc003oui.3 uc011dvf.2) ENST00000457278
    miRNA
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    Block miRNA regulation of human, mouse, rat SRF using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SRF (see all 81):
    hsa-miR-642a hsa-miR-371-5p hsa-miR-550a* hsa-miR-877* hsa-miR-149 hsa-miR-376c hsa-miR-200b hsa-miR-564
    SwitchGear 3'UTR luciferase reporter plasmidSRF 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SRF
    Clone
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    GenScript: all cDNA clones in your preferred vector: SRF (NM_003131)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRF
    Addgene plasmids for SRF 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SRF
    OriGene qSTAR qPCR primer pairs in human, mouse for SRF
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SRF
      QuantiTect SYBR Green Assays in human, mouse, rat SRF
      QuantiFast Probe-based Assays in human, mouse, rat SRF

    Additional mRNA sequence: 

    AB209128.1 AK300467.1 BC048211.1 BC052572.1 J03161.1 

    5 DOTS entries:

    DT.451694  DT.100029210  DT.95131188  DT.100787005  DT.100706306 

    Selected AceView cDNA sequences (see all 255):

    CR594188 CF529507 BU616078 BM472069 AW137527 BQ065950 BU626374 CA440206 
    BF733797 BU616691 BM714062 BG232058 BQ059564 BM469317 BE044291 BQ071914 
    CA427771 BM994090 BM694060 N89658 BE621028 AI080234 BF881885 T64473 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SRF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCACAGTCC
    SRF Expression
    About this image


    SRF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Smooth Muscle (Muscoskeletal System)    fully expand to see all 3 entries
             Vascular Smooth Muscle Cells Coronary Capillary Plexus
             Contractile smooth muscle-like cells
     
     Heart (Cardiovascular System)    fully expand to see all 4 entries
             Vascular Smooth Muscle Cells Coronary Capillary Plexus
             Cardiac progenitor cells
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Epithelial Cells
             Spinous Keratinocytes Stratified Epidermis
    SRF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SRF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.520140
        Pathway & Disease-focused RT2 Profiler PCR Arrays including SRF: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              Synaptic Plasticity in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SRF
    OriGene qSTAR qPCR primer pairs in human, mouse for SRF
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SRF
    QuantiTect SYBR Green Assays in human, mouse, rat SRF
    QuantiFast Probe-based Assays in human, mouse, rat SRF
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SRF gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srf1 , 5 serum response factor1, 5 94.91(n)1
    96.43(a)1
      17 (22.90 cM)5
    208071  NM_020493.21  NP_065239.11 
     465468395 
    chicken
    (Gallus gallus)
    Aves SRF1 serum response factor (c-fos serum response element-binding more 82.11(n)
    86.41(a)
      396103  NM_001252141.1  NP_001239070.1 
    lizard
    (Anolis carolinensis)
    Reptilia SRF6
    serum response factor (c-fos serum response elemen...
    80(a)
    1 ↔ 1
    2(143872482-143955138)
    African clawed frog
    (Xenopus laevis)
    Amphibia srf-A2 serum response factor 78.45(n)    X56451.1 
    zebrafish
    (Danio rerio)
    Actinopterygii srf2 serum response factor 72.28(n)   30431  BC050480.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta bs6
    blistered
    36(a)
    1 ↔ 1
    2R(20230389-20263998)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-1206
    Protein UNC-120 (unc-120) mRNA, complete cds
    35(a)
    1 ↔ 1
    I(8460225-8463014) WBGene00006844
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ARG80(YMR042W)4 Transcription factor involved in regulation of arginine-responsive more   --   13(352603-353136) 855059  NP_013756.1 


    ENSEMBL Gene Tree for SRF (if available)
    TreeFam Gene Tree for SRF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SRF (see all 202)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1426737351,2
    --43136923(+) GTGATA/TCCCAT 1 -- us2k10--------
    rs1473525001,2
    --43137305(+) CATGGC/TGAAAC 1 -- us2k10--------
    rs582309671,2
    C--43137508(+) AAAAA-/A/AA  
            
    CTCAG
    1 -- us2k11NA 2
    rs109480661,2
    C,F,A,H--43137514(+) ACTCAG/TGGAAT 1 -- us2k118Minor allele frequency- T:0.36NS EA WA NA CSA 2339
    rs789752471,2
    C,F--43137545(+) ATTGCG/ATCTGG 1 -- us2k11Minor allele frequency- A:0.10WA 118
    rs2012982731,2
    --43137723(+) TTTAA-/GGTTTT 1 -- us2k10--------
    rs355744241,2
    C,F--43137725(+) TTAAGG/TTTTTT 1 -- us2k12Minor allele frequency- T:0.50WA CSA 4
    rs358820211,2
    C--43137740(+) TTTTT-/T/TT/T
    TTTTTTTT
    TTTTT
    2 -- us2k1 cds11NA 2
    rs69159701,2
    C,A--43137763(+) cacggG/Tggttc 1 -- us2k10--------
    rs93812351,2
    A--43137892(+) ggccaA/Gagtgg 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SRF (43138920 - 43149244 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SRF:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv521730CNV Loss19592680
    nsv819840CNV Gain19587683

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SRF
    DNA2.0 Custom Variant and Variant Library Synthesis for SRF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600589    OMIM disorders: --

    9 diseases for SRF:    
    About MalaCards
    rheumatoid nodulosis    miller fisher syndrome    fetal alcohol spectrum disorder    fumarate hydratase deficiency
    eosinophilic gastroenteritis    rheumatoid vasculitis    syringomyelia    rosai-dorfman disease
    rheumatoid arthritis


    Find genes that share disorders with SRF           About GenesLikeMe

    Selected Novoseek inferred disease relationships for SRF gene (see all 91)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rheumatoid arthritis 52.4 13 8849349 (1), 15742441 (1), 1417131 (1), 10716453 (1) (see all 13)
    leukemia t-cell 52.3 14 7933111 (2), 15207639 (1), 17898074 (1), 8361755 (1) (see all 6)
    megakaryoblastic leukemia acute 51.8 1 19136660 (1)
    rheumatoid nodule 44.1 3 8257029 (1), 8833048 (1), 20084988 (1)
    rheumatoid vasculitis 28.9 1 8182655 (1)
    congenital heart block 28.6 2 10402042 (1), 8974073 (1)
    hypertrophy 25 14 10368339 (3), 15221330 (2), 18252708 (1), 16556869 (1) (see all 9)
    lupus erythematosus systemic 23.3 3 2002277 (1), 14872509 (1), 8383027 (1)
    arthritis 23.2 6 10366125 (1), 2066957 (1), 19921094 (1), 8039045 (1) (see all 6)
    autoimmune diseases 21.8 1 14872509 (1)

    Genetic Association Database (GAD): SRF
    Human Genome Epidemiology (HuGE) Navigator: SRF (9 documents)

    Export disorders for SRF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SRF gene, integrated from 10 sources (see all 737):
    (articles sorted by number of sources associating them with SRF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element. (PubMed id 3203386)1, 2, 3 Norman C.... Treisman R. (Cell 1988)
    2. The carboxyl-terminal transactivation domain of human serum response factor contains DNA-activated protein kinase phosphorylation sites. (PubMed id 8407951)1, 2, 9 Liu S.-H....Ng S.-Y. (J. Biol. Chem. 1993)
    3. C-terminal phosphorylation of the serum-response factor. (PubMed id 8375385)1, 2, 9 Janknecht R.... Nordheim A. (Eur. J. Biochem. 1993)
    4. Identification of multiple SRF N-terminal phosphorylation sites affecting DNA binding properties. (PubMed id 1547771)1, 2, 9 Janknecht R....Stunnenberg H.G. (EMBO J. 1992)
    5. Localization of O-GlcNAc modification on the serum response transcription factor. (PubMed id 1512232)1, 2, 9 Reason A.J.... Dell A. (J. Biol. Chem. 1992)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin. (PubMed id 19350017)1, 2 Brandt D.T.... Grosse R. (Nat. Cell Biol. 2009)
    9. The LIM protein leupaxin is enriched in smooth muscle and functions as an serum response factor cofactor to induce smooth muscle cell gene transcription. (PubMed id 18497331)1, 2 Sundberg-Smith L.J....Taylor J.M. (Circ. Res. 2008)
    10. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6722 HGNC: 11291 AceView: SRF Ensembl:ENSG00000112658 euGenes: HUgn6722
    ECgene: SRF Kegg: 6722 H-InvDB: SRF

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SRF Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SRF Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SRF gene:
    Search GeneIP for patents involving SRF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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