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Aliases for SRF Gene

Aliases for SRF Gene

  • Serum Response Factor 2 3 5
  • C-Fos Serum Response Element-Binding Transcription Factor 2 3
  • Minichromosome Maintenance 1 Homolog (S. Cerevisiae) 2
  • Minichromosome Maintenance 1 Homolog 3
  • MCM1 3

External Ids for SRF Gene

Previous GeneCards Identifiers for SRF Gene

  • GC06P043141
  • GC06P043185
  • GC06P043247
  • GC06P042855

Summaries for SRF Gene

Entrez Gene Summary for SRF Gene

  • This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

GeneCards Summary for SRF Gene

SRF (Serum Response Factor) is a Protein Coding gene. Diseases associated with SRF include Lymphangioleiomyomatosis and Fumarate Hydratase Deficiency. Among its related pathways are IL-2 Pathway and HTLV-I infection. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding.

UniProtKB/Swiss-Prot for SRF Gene

  • SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5 of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation.

Gene Wiki entry for SRF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRF Gene

Genomics for SRF Gene

Regulatory Elements for SRF Gene

Enhancers for SRF Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F043263 1 Ensembl ENCODE 20.5 +92.3 92306 0.4 HDGF MLX ARID4B DMAP1 ZNF48 ZNF143 ZNF263 MIER2 REST KAT8 SRF DNPH1 TTBK1 LOC105375064
GH06F043700 0.9 Ensembl ENCODE 20.4 +534.4 534419 9.8 HDGF PKNOX1 ARNT MLX ARID4B FEZF1 ZNF2 SLC30A9 FOS ZNF263 GLTSCR1L SRF ENSG00000271970 CUL7 VEGFA RSPH9 GTPBP2 MAD2L1BP RPL24P4 RPS2P29
GH06F043735 0.6 Ensembl ENCODE 20.4 +565.7 565659 2.9 PKNOX1 ARNT ARID4B DMAP1 SLC30A9 ZNF121 GLIS2 ZNF263 SP5 MXD4 SRF LOC105375066 KLHDC3 LOC100132242
GH06F043925 1 FANTOM5 Ensembl ENCODE 20.4 +755.8 755828 3.2 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B FEZF1 ZNF2 SLC30A9 ZNF302 SRF POLH RPS2P29 AARS2 MAD2L1BP NFKBIE TJAP1 GTPBP2 LOC105375067 GC06M043993
GH06F043624 0.7 ENCODE 20.4 +456.7 456744 7.4 CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC MEF2D POLH RRP36 RPS2P29 LOC101929726 CUL7 SRF ENSG00000223469 RPS2P28 RPL29P16 CUL9
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SRF on UCSC Golden Path with GeneCards custom track

Promoters for SRF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001217014 406 3400 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for SRF Gene

Chromosome:
6
Start:
43,171,295 bp from pter
End:
43,181,507 bp from pter
Size:
10,213 bases
Orientation:
Plus strand

Genomic View for SRF Gene

Genes around SRF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRF Gene

Proteins for SRF Gene

  • Protein details for SRF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11831-SRF_HUMAN
    Recommended name:
    Serum response factor
    Protein Accession:
    P11831
    Secondary Accessions:
    • Q5T648

    Protein attributes for SRF Gene

    Size:
    508 amino acids
    Molecular mass:
    51593 Da
    Quaternary structure:
    • Binds DNA as a multimer, probably a dimer. Interacts with MLLT7/FOXO4, NKX3A and SSRP1. Interacts with ARID2 and SRFBP1 (By similarity). Forms complexes with ARID2, MYOCD, NKX2-5 and SRFBP1 (By similarity). Forms a nuclear ternary complex with MKL1 and SCAI (PubMed:19350017). Interacts with LPXN (PubMed:18497331). Interacts with OLFM2; the interaction promotes dissociation of SRF from the transcriptional repressor HEY2, facilitates binding of SRF to target genes and promotes smooth muscle differentiation (PubMed:25298399).

    Three dimensional structures from OCA and Proteopedia for SRF Gene

neXtProt entry for SRF Gene

Post-translational modifications for SRF Gene

  • Phosphorylated by PRKDC.
  • Glycosylation at Ser 277, Ser 307, Ser 309, Ser 316, and Ser 383
  • Modification sites at PhosphoSitePlus

Other Protein References for SRF Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SRF Gene

Domains & Families for SRF Gene

Gene Families for SRF Gene

Protein Domains for SRF Gene

Suggested Antigen Peptide Sequences for SRF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P11831

UniProtKB/Swiss-Prot:

SRF_HUMAN :
  • Contains 1 MADS-box domain.
Domain:
  • Contains 1 MADS-box domain.
genes like me logo Genes that share domains with SRF: view

Function for SRF Gene

Molecular function for SRF Gene

UniProtKB/Swiss-Prot Function:
SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5 of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation.

Gene Ontology (GO) - Molecular Function for SRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA,ISS --
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0000983 contributes_to transcription factor activity, RNA polymerase II core promoter sequence-specific IMP 18296735
GO:0000987 core promoter proximal region sequence-specific DNA binding IEA --
GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding IEA --
genes like me logo Genes that share ontologies with SRF: view
genes like me logo Genes that share phenotypes with SRF: view

Animal Models for SRF Gene

MGI Knock Outs for SRF:

Animal Model Products

Transcription Factor Targets for SRF Gene

Selected GeneGlobe predicted Target genes for SRF
Targeted motifs for SRF Gene
HOMER Transcription Factor Regulatory Elements motif SRF
  • Consensus sequence: CCATATATGGNA Submotif: canonical Cell Type: PUER

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SRF

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for SRF Gene

Localization for SRF Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRF Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRF Gene COMPARTMENTS Subcellular localization image for SRF gene
Compartment Confidence
nucleus 5
cytoskeleton 2
plasma membrane 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IEA --
GO:0005634 nucleus IEA,IDA 2108863
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,TAS 15180964
genes like me logo Genes that share ontologies with SRF: view

Pathways & Interactions for SRF Gene

genes like me logo Genes that share pathways with SRF: view

SIGNOR curated interactions for SRF Gene

Activates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for SRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001569 branching involved in blood vessel morphogenesis IEA --
GO:0001666 response to hypoxia IEP 19098903
GO:0001701 in utero embryonic development IEA --
GO:0001707 mesoderm formation IEA --
GO:0001764 neuron migration IEA --
genes like me logo Genes that share ontologies with SRF: view

Drugs & Compounds for SRF Gene

(53) Drugs for SRF Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(42) Additional Compounds for SRF Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SRF: view

Transcripts for SRF Gene

mRNA/cDNA for SRF Gene

(255) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SRF Gene

Serum response factor (c-fos serum response element-binding transcription factor):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SRF

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRF Gene

No ASD Table

Relevant External Links for SRF Gene

GeneLoc Exon Structure for
SRF
ECgene alternative splicing isoforms for
SRF

Expression for SRF Gene

mRNA expression in normal human tissues for SRF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SRF Gene

This gene is overexpressed in Adipocyte (18.2), Fetal gut (15.8), CD8 Tcells (15.8), Fetal heart (10.0), and Prostate (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SRF Gene



NURSA nuclear receptor signaling pathways regulating expression of SRF Gene:

SRF

SOURCE GeneReport for Unigene cluster for SRF Gene:

Hs.520140
genes like me logo Genes that share expression patterns with SRF: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SRF Gene

Orthologs for SRF Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SRF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRF 34 35
  • 98.47 (n)
mouse
(Mus musculus)
Mammalia Srf 34 16 35
  • 94.91 (n)
rat
(Rattus norvegicus)
Mammalia Srf 34
  • 94.58 (n)
dog
(Canis familiaris)
Mammalia SRF 34 35
  • 94.52 (n)
cow
(Bos Taurus)
Mammalia SRF 34 35
  • 93.96 (n)
oppossum
(Monodelphis domestica)
Mammalia SRF 35
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves SRF 34 35
  • 82.11 (n)
lizard
(Anolis carolinensis)
Reptilia SRF 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia srf 34
  • 68.2 (n)
African clawed frog
(Xenopus laevis)
Amphibia srf-A 34
zebrafish
(Danio rerio)
Actinopterygii srfa 34 35
  • 67.85 (n)
SRF (1 of 2) 35
  • 55 (a)
OneToMany
srf 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13739 34
fruit fly
(Drosophila melanogaster)
Insecta bs 35
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea unc-120 35
  • 35 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MCM1 35
  • 33 (a)
OneToMany
ARG80 35 37
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10664 35
  • 42 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3406 34
Species where no ortholog for SRF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRF Gene

ENSEMBL:
Gene Tree for SRF (if available)
TreeFam:
Gene Tree for SRF (if available)

Paralogs for SRF Gene

No data available for Paralogs for SRF Gene

Variants for SRF Gene

Sequence variations from dbSNP and Humsavar for SRF Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10948066 -- 43,169,776(+) ACTCA(G/T)GGAAT upstream-variant-2KB
rs111773489 -- 43,177,850(+) GCGGA(G/T)CTTGC intron-variant
rs111903566 -- 43,173,299(+) CTTCC(A/G)TAACC intron-variant
rs112496612 -- 43,177,259(+) GTCTC(A/G)CTCTC intron-variant
rs112542835 -- 43,177,779(+) GCTTG(A/G)TGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRF Gene

Variant ID Type Subtype PubMed ID
esv3571027 CNV loss 25503493
nsv1017398 CNV gain 25217958
nsv521730 CNV loss 19592680
nsv819840 CNV gain 19587683

Variation tolerance for SRF Gene

Residual Variation Intolerance Score: 20.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRF Gene

Disorders for SRF Gene

MalaCards: The human disease database

(3) MalaCards diseases for SRF Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lymphangioleiomyomatosis
  • lymphangioleiomyomatosis, somatic
fumarate hydratase deficiency
  • fumarase deficiency
rheumatoid vasculitis
- elite association - COSMIC cancer census association via MalaCards
Search SRF in MalaCards View complete list of genes associated with diseases

Relevant External Links for SRF

Genetic Association Database (GAD)
SRF
Human Genome Epidemiology (HuGE) Navigator
SRF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRF
genes like me logo Genes that share disorders with SRF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SRF Gene

Publications for SRF Gene

  1. C-terminal phosphorylation of the serum-response factor. (PMID: 8375385) Janknecht R. … Nordheim A. (Eur. J. Biochem. 1993) 3 4 22 64
  2. The carboxyl-terminal transactivation domain of human serum response factor contains DNA-activated protein kinase phosphorylation sites. (PMID: 8407951) Liu S.-H. … Ng S.-Y. (J. Biol. Chem. 1993) 3 4 22 64
  3. Localization of O-GlcNAc modification on the serum response transcription factor. (PMID: 1512232) Reason A.J. … Dell A. (J. Biol. Chem. 1992) 3 4 22 64
  4. Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element. (PMID: 3203386) Norman C. … Treisman R. (Cell 1988) 2 3 4 64
  5. Olfactomedin 2, a novel regulator for transforming growth factor- beta-induced smooth muscle differentiation of human embryonic stem cell-derived mesenchymal cells. (PMID: 25298399) Shi N. … Chen S.Y. (Mol. Biol. Cell 2014) 3 4 64

Products for SRF Gene

Sources for SRF Gene

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