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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SRF Gene

protein-coding GIFtS: 60
GCID: GC06P043138

serum response factor (c-fos serum response element-binding...

Explore 121 diseases affiliated with
SRF via

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Serum Response Factor (C-Fos Serum Response Element-Binding Transcription Factor)¹ ²
MCM1¹ ²
Serum Response Factor²

External Ids:	HGNC: 11291¹	Entrez Gene: 6722²	Ensembl: ENSG00000112658⁷	OMIM: 600589⁵	UniProtKB: P11831³

Export aliases for SRF gene to outside databases

Previous GC identifers: GC06P043141 GC06P043185 GC06P043247 GC06P042855

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SRF:

This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a

member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to

the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many

immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth,

and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated

protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SRF_HUMAN, P11831

Function: SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad

symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Required for

cardiac differentiation and maturation

Gene Wiki entry for SRF (Serum response factor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007592.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SRF gene promoter:
SRF SRF (504 AA) MyoD Nkx2-5 YY1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SRF promoter sequence

Search SABiosciences Chromatin IP Primers for SRF

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRF

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1 Ensembl cytogenetic band: 6p21.1 HGNC cytogenetic band: 6p

SRF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRF gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P043138: view genomic region (about GC identifiers)

Start:	43,138,920 bp from pter	End:	43,149,244 bp from pter
Size:	10,325 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SRF_HUMAN, P11831 (See protein sequence)

Recommended Name: Serum response factor

Size: 508 amino acids; 51593 Da

Subunit: Binds DNA as a multimer, probably a dimer. Interacts with MLLT7/FOXO4, NKX3A and SSRP1. Interacts with ARID2

and SRFBP1 (By similarity). Forms complexes with ARID2, MYOCD, NKX2-5 and SRFBP1 (By similarity). Forms a nuclear

ternary complex with MKL1 and SCAI. Interacts with LPXN

Subcellular location: Nucleus

3 PDB 3D structures from and Proteopedia for SRF:

1HBX (3D)

1K6O (3D)

1SRS (3D)

Secondary accessions: Q5T648

Explore the universe of human proteins at neXtProt for SRF: NX_P11831

Post-translational modifications:

Phosphorylated by PRKDC¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P11831

SRF Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003122.1

ENSEMBL proteins:

ENSP00000265354 ENSP00000401320

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	OriGene Purified Protein: SRF OriGene Protein Over-expression Lysate: SRF OriGene Custom Protein Services for SRF
	GenScript Custom Purified and Recombinant Proteins Services for SRF
	Novus Biologicals SRF Protein Novus Biologicals SRF Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SRF

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000790	nuclear chromatin	IEA	--
GO:0005634	nucleus	IDA	2108863
GO:0005737	cytoplasm	TAS	15180964
GO:0005783	endoplasmic reticulum	--	--

SRF for ontologies About GeneDecksing

SRF Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of SRF
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	Cell Signaling Technology (CST) Antibodies for SRF
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	GenScript Custom Superior Antibodies Services for SRF
	Novus Biologicals SRF Antibodies
	Search for Antibodies for SRF at Abcam
	Uscn Antibodies for SRF
	ThermoFisher Antibodies for SRF

Assay Products for SRF:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SRF
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SRF

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SRF for domains About GeneDecksing

1 InterPro domain/family:

IPR002100 TF_MADSbox

Graphical View of Domain Structure for InterPro Entry P11831

ProtoNet protein and cluster: P11831

1 Blocks protein family: IPB002100 Transcription factor

UniProtKB/Swiss-Prot: SRF_HUMAN, P11831

Similarity: Contains 1 MADS-box domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SRF_HUMAN, P11831

Function: SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad

symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Required for

cardiac differentiation and maturation

		10/926 SABiosciences Target genes for SRF (see all 926):
		A2ML1 AATK ABCA13 ABCC5 ABCD1 ABCG5 ABCG8 ABHD12 ABLIM1 ABRA

miRNA Products:		miRTarBase miRNAs that target SRF: hsa-mir-122 (MIRT000365)

		OriGene 3'-UTR Clone: SRF Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SRF
		8/81 QIAGEN miScript miRNA Assays for microRNAs that regulate SRF (see all 81):
		hsa-miR-642a hsa-miR-371-5p hsa-miR-550a* hsa-miR-877* hsa-miR-149 hsa-miR-376c hsa-miR-200b hsa-miR-564

		SwitchGear 3'UTR luciferase reporter plasmid: SRF 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SRF (see all 7) OriGene shRNA RFP: SRF OriGene siRNA: SRF
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRF

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SRF

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRF (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRF OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SRF (NM_003131)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRF
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRF

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SRF
		Search LifeMap BioReagents cell lines for SRF

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRF

Gene Ontology (GO): 5/15 molecular function terms (GO ID links to tree view) (see all 15): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	ISS	--
GO:0000983	contributes to RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity	IMP	18296735
GO:0001076	RNA polymerase II transcription factor binding transcription factor activity	IEA	--
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	IDA	--
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	ISS	--

SRF for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for SRF: Srf^tm1Nor Srf^tm2.2Nor Srf^tm2.3Nor
     14 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Srf):

behavior/neurological	cardiovascular system	cellular	embryogenesis	growth/size
hematopoietic system	homeostasis/metabolism	immune system	mortality/aging	muscle
no phenotypic analysis	normal	respiratory system	skeleton

SRF for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/30 super-pathways (see all 30) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

TRKA Signaling

TRKA Signaling

1.00

NGF Pathway

0.75

MAPK signaling pathway

MAPK signaling pathway

1.00

MAPK signaling pathway

0.50

PKC-Theta Pathway

TCR Signaling

0.68

PDGF Pathway

0.35

Development HGF signaling pathway

Development PDGF signaling via MAPK cascades

0.41

Development_PDGF signaling via MAPK cascades

0.41

ErbB4 Pathway

LPS Stimulated MAPK Signaling

0.36

Growth Hormone Signaling

0.32

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for SRF

	Development PDGF signaling via MAPK cascades
	Immune response IL-6 signaling pathway

5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SRF (see all 15)

	Chemokine Signaling
	TRKA Signaling
	Cellular Transformation by HTLV1
	PDGF Pathway
	Signaling Involved in Cardiac Hypertrophy

2 Cell Signaling Technology (CST) Pathways for SRF

	MAP Kinase Signaling
	Cytoskeletal Signaling

2 GeneGo (Thomson Reuters) Pathways for SRF

	Immune response IL-6 signaling pathway
	Development PDGF signaling via MAPK cascades

5/14 BioSystems Pathways for SRF (see all 14)

	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
	Heart Development
	SRF and miRs in Smooth Muscle Differentiation and Proliferation
	Serotonin Receptor 4/6/7 and NR3C Signaling
	MAPK signaling pathway

1 Kegg Pathway (Kegg details for SRF):

MAPK signaling pathway

SRF for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SRF

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/101 Interacting proteins for SRF (P11831^{1, 2, 3} ENSP00000265354⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 101)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MYOD1	P15172²^,³, ENSP00000250003⁴	MINT-15522 MINT-15523 I2D: score=2 STRING: ENSP00000250003
MKL1	Q969V6¹^,³, ENSP00000347847⁴	EBI-493034,EBI-493122 I2D: score=4 STRING: ENSP00000347847
MKL2	Q9ULH7¹^,³, ENSP00000339086⁴	EBI-493034,EBI-493007 I2D: score=3 STRING: ENSP00000339086
MYOG	P15173²^,³, ENSP00000241651⁴	MINT-16345 MINT-16346 I2D: score=4 STRING: ENSP00000241651
MYOCD	Q8IZQ8¹^,³, ENSP00000341835⁴	EBI-493034,EBI-493384 I2D: score=4 STRING: ENSP00000341835

About this table

Gene Ontology (GO): 5/67 biological process terms (GO ID links to tree view) (see all 67): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001569	patterning of blood vessels	IEA	--
GO:0001666	response to hypoxia	IEP	19098903
GO:0001701	in utero embryonic development	--	--
GO:0001707	mesoderm formation	IEA	--
GO:0001764	neuron migration	IEA	--

SRF for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SRF for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SRF
10/95 Novoseek chemical compound relationships for SRF gene (see all 95) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
mdi-a	60.5	6	11509578 (1), 20071339 (1), 12429848 (1)
jasplakinolide	51.2	6	17332502 (1), 11502570 (1), 19874818 (1), 15240009 (1)
ganglioside gq1b	47.4	1	9753137 (1)
phosphatidylinositol	28.6	3	1939110 (1), 11342553 (1), 11859076 (1)
cyclic amp	26.2	10	7507831 (1), 9658126 (1), 10342376 (1), 10961986 (1) (see all 8)
il-12	22	1	9462175 (1)
mannose	21.1	2	1846001 (1), 9815228 (1)
thymidine	21	2	8535215 (1), 12704643 (1)
12-o-tetradecanoylphorbol 13-acetate	14.7	6	1656100 (1), 11980664 (1), 9880563 (1)
polysulfone	14.5	2	8675359 (1)

Search CenterWatch for drugs/clinical trials and news about SRF

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SRF gene:

NM_003131.2

Unigene Cluster for SRF:

Serum response factor (c-fos serum response element-binding transcription factor)

Hs.520140 [show with all ESTs]

Unigene Representative Sequence: AB209128

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000265354(uc003oui.3 uc011dvf.2) ENST00000457278

miRNA Products:		OriGene 3'-UTR Clone: SRF Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SRF
		8/81 QIAGEN miScript miRNA Assays for microRNAs that regulate SRF (see all 81):
		hsa-miR-642a hsa-miR-371-5p hsa-miR-550a* hsa-miR-877* hsa-miR-149 hsa-miR-376c hsa-miR-200b hsa-miR-564

		SwitchGear 3'UTR luciferase reporter plasmid: SRF 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SRF (see all 7) OriGene shRNA RFP: SRF OriGene siRNA: SRF
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRF

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRF (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRF OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SRF (NM_003131)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRF
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRF

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRF
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRF

Additional cDNA sequence:

AB209128.1 AK300467.1 BC048211.1 BC052572.1 J03161.1

5 DOTS entries:

DT.451694 DT.100029210 DT.95131188 DT.100787005 DT.100706306

24/255 AceView cDNA sequences (see all 255):

CA442495 BQ072087 BQ056072 J03161 BQ001805 BM091479 BE856155 BI964212

BF881885 BM972180 BC052572 BU626374 CF529507 BM704607 CR594188 CA450413

BM472069 AL521878 BM466600 CD671136 BQ065950 CR595609 BQ012660 AI080234

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SRF expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTCACAGTCC

About this image

SRF expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Coronary Capillary Plexus

Vascular Smooth Muscle Cells

Selective marker (cell-identifying gene)

Epicardium, Smooth Muscle

Endothelium

Veins

Vascular Smooth Muscle Cells

Smooth Muscle

Heart

Aortic Arch Arteries

Vascular Smooth Muscle Cells

Myocardium, Neural Crest, Smooth Muscle

Heart

Endocardium

Vascular Smooth Muscle Cells

Smooth Muscle

Myocardium

Myocardium

Myocardium

Juxtaglomerular Cells

Kidney, Smooth Muscle

Lateral Plate Mesoderm

Cardiogenic Mesoderm

Pre-myocardial Cells

Myocardium

Mesoderm

Cardiac progenitor Cells

Endocardium, Myocardium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SRF Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SRF

SOURCE GeneReport for Unigene cluster: Hs.520140

SABiosciences Expression via Pathway-Focused PCR Arrays including SRF:

cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

PI3K-AKT Signaling Pathway in human mouse rat

Synaptic Plasticity in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SRF Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SRF
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRF
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRF

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRF

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SRF gene from 7/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Srf^{1 , 5}	serum response factor^{1, 5}	95.17(n)¹ 97.22(a)¹		17 (22.90 cM)⁵ 20807¹ NM_020493.2¹ NP_065239.1¹ 46546839⁵
chicken (Gallus gallus)	Aves	SRF¹	serum response factor (c-fos serum response element-binding more	81.18(n) 84.79(a)		396103 NM_001252141.1 NP_001239070.1
lizard (Anolis carolinensis)	Reptilia	SRF⁶	--	80(a)	1 ↔ 1	2(143872482-143955138)
African clawed frog (Xenopus laevis)	Amphibia	srf-A²	serum response factor	78.45(n)		X56451.1
zebrafish (Danio rerio)	Actinopterygii	srf²	serum response factor	72.28(n)		30431 BC050480.1
fruit fly (Drosophila melanogaster)	Insecta	bs¹	blistered	53.77(n) 50.87(a)		37890 NM_166667.1 NP_726438.1
worm (Caenorhabditis elegans)	Secernentea	unc-120⁶	UNCoordinated family member (unc-120)	34(a)	1 ↔ 1	I(8460219-8463008)

ENSEMBL Gene Tree for SRF (if available)
TreeFam Gene Tree for SRF (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs142673735^1,2		--	43136923(+)	`GTGATA/TCCCAT`	1	--	us2k¹		0	--	--	--	--
rs147352500^1,2		--	43137305(+)	`CATGGC/TGAAAC`	1	--	us2k¹		0	--	--	--	--
rs10948066^1,2	C,F,A,H,	--	43137514(+)	`ACTCAG/TGGAAT`	1	--	us2k¹		18		NS EA WA NA CSA	2339
rs78975247^1,2	C,F,	--	43137545(+)	`ATTGCG/ATCTGG`	1	--	us2k¹		1		WA	118
rs201298273^1,2		--	43137723(+)	`TTTAA-/GGTTTT`	1	--	us2k¹		0	--	--	--	--
rs35574424^1,2	C,F,	--	43137725(+)	`TTAAGG/TTTTTT`	1	--	us2k¹		2		WA CSA	4
rs6915970^1,2	C,A	--	43137763(+)	`cacggG/Tggttc`	1	--	us2k¹		0	--	--	--	--
rs9381235^1,2	A	--	43137892(+)	`ggccaA/Gagtgg`	1	--	us2k¹		0	--	--	--	--
rs6941383^1,2	C,A	--	43137984(+)	`gctcaA/Gatccc`	1	--	us2k¹		0	--	--	--	--
rs9472020^1,2	C,A	--	43138068(+)	`CCAGAA/GAAGTG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SRF (43138920 - 43149244 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SRF
1 CNV: 59342

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SRF for disorders           About GeneDecksing

OMIM gene information: 600589    OMIM disorders: --

20/121 diseases for SRF (see all 121):    About MalaCards

miller fisher syndrome guillain-barre syndrome spondyloepiphyseal dysplasia tarda spondyloepiphyseal dysplasia tarda with progressive arthropathy

rosai-dorfman disease spinal cord injury spondyloepiphyseal dysplasia human t-cell leukemia virus type 1

congenital heart block retinol binding protein fetal alcohol spectrum disorder heart block

pre-eclampsia rheumatoid nodulosis acute myocardial infarction retinal detachment

non-hodgkin lymphoma eosinophilic gastroenteritis coronary heart disease myocardial infarction

10/91 Novoseek disease relationships for SRF gene (see all 91) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
rheumatoid arthritis	52.4	13	8849349 (1), 15742441 (1), 1417131 (1), 10716453 (1) (see all 13)
leukemia t-cell	52.3	14	7933111 (2), 15207639 (1), 17898074 (1), 8361755 (1) (see all 6)
megakaryoblastic leukemia acute	51.8	1	19136660 (1)
rheumatoid nodule	44.1	3	8257029 (1), 8833048 (1), 20084988 (1)
rheumatoid vasculitis	28.9	1	8182655 (1)
congenital heart block	28.6	2	10402042 (1), 8974073 (1)
hypertrophy	25	14	10368339 (3), 15221330 (2), 18252708 (1), 16556869 (1) (see all 9)
lupus erythematosus systemic	23.3	3	2002277 (1), 14872509 (1), 8383027 (1)
arthritis	23.2	6	10366125 (1), 2066957 (1), 19921094 (1), 8039045 (1) (see all 6)
autoimmune diseases	21.8	1	14872509 (1)

Human Genome Epidemiology (HuGE) Navigator: SRF (9 documents)

Export disorders for SRF gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SRF gene, integrated from 9 sources (see all 727):
(articles sorted by number of sources associating them with SRF)

Utopia: connect your pdf to the dynamic
world of online information

Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element. (PubMed id 3203386)^{1, 2, 3} Norman C.... Treisman R. (1988)
The carboxyl-terminal transactivation domain of human serum response factor contains DNA-activated protein kinase phosphorylation sites. (PubMed id 8407951)^{1, 2, 9} Liu S.-H....Ng S.-Y. (1993)
C-terminal phosphorylation of the serum-response factor. (PubMed id 8375385)^{1, 2, 9} Janknecht R.... Nordheim A. (1993)
Identification of multiple SRF N-terminal phosphorylation sites affecting DNA binding properties. (PubMed id 1547771)^{1, 2, 9} Janknecht R....Stunnenberg H.G. (1992)
Localization of O-GlcNAc modification on the serum response transcription factor. (PubMed id 1512232)^{1, 2, 9} Reason A.J.... Dell A. (1992)
SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin. (PubMed id 19350017)^{1, 2} Brandt D.T.... Grosse R. (2009)
The LIM protein leupaxin is enriched in smooth muscle and functions as an serum response factor cofactor to induce smooth muscle cell gene transcription. (PubMed id 18497331)^{1, 2} Sundberg-Smith L.J....Taylor J.M. (2008)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Phenotypic modulation of smooth muscle cells through interaction of Foxo4 and myocardin. (PubMed id 16054032)^{1, 2} Liu Z.-P.... Olson E.N. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6722	HGNC: 11291	AceView: SRF	Ensembl:ENSG00000112658	euGenes: HUgn6722
ECgene: SRF	Kegg: 6722	H-InvDB: SRF

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SRF	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SRF	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for SRF gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SRF gene:
Search GeneIP for patents involving SRF

GeneCards and IP:
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