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Aliases for SRF Gene

Aliases for SRF Gene

  • Serum Response Factor 2 3 5
  • C-Fos Serum Response Element-Binding Transcription Factor 2 3
  • Serum Response Factor (C-Fos Serum Response Element-Binding Transcription Factor) 3
  • Minichromosome Maintenance 1 Homolog (S. Cerevisiae) 2
  • Minichromosome Maintenance 1 Homolog 3
  • MCM1 3

External Ids for SRF Gene

Previous GeneCards Identifiers for SRF Gene

  • GC06P043141
  • GC06P043185
  • GC06P043247
  • GC06P042855

Summaries for SRF Gene

Entrez Gene Summary for SRF Gene

  • This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

GeneCards Summary for SRF Gene

SRF (Serum Response Factor) is a Protein Coding gene. Diseases associated with SRF include fumarate hydratase deficiency. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding.

UniProtKB/Swiss-Prot for SRF Gene

  • SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5 of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation.

Gene Wiki entry for SRF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRF Gene

Genomics for SRF Gene

Regulatory Elements for SRF Gene

Promoters for SRF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SRF on UCSC Golden Path with GeneCards custom track

Genomic Location for SRF Gene

Chromosome:
6
Start:
43,171,295 bp from pter
End:
43,181,507 bp from pter
Size:
10,213 bases
Orientation:
Plus strand

Genomic View for SRF Gene

Genes around SRF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRF Gene

Proteins for SRF Gene

  • Protein details for SRF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11831-SRF_HUMAN
    Recommended name:
    Serum response factor
    Protein Accession:
    P11831
    Secondary Accessions:
    • Q5T648

    Protein attributes for SRF Gene

    Size:
    508 amino acids
    Molecular mass:
    51593 Da
    Quaternary structure:
    • Binds DNA as a multimer, probably a dimer. Interacts with MLLT7/FOXO4, NKX3A and SSRP1. Interacts with ARID2 and SRFBP1 (By similarity). Forms complexes with ARID2, MYOCD, NKX2-5 and SRFBP1 (By similarity). Forms a nuclear ternary complex with MKL1 and SCAI (PubMed:19350017). Interacts with LPXN (PubMed:18497331). Interacts with OLFM2; the interaction promotes dissociation of SRF from the transcriptional repressor HEY2, facilitates binding of SRF to target genes and promotes smooth muscle differentiation (PubMed:25298399).

    Three dimensional structures from OCA and Proteopedia for SRF Gene

neXtProt entry for SRF Gene

Proteomics data for SRF Gene at MOPED

Post-translational modifications for SRF Gene

  • Phosphorylated by PRKDC.
  • Glycosylation at Ser 277, Ser 307, Ser 309, Ser 316, and Ser 383
  • Modification sites at PhosphoSitePlus

Other Protein References for SRF Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SRF (SRF)

No data available for DME Specific Peptides for SRF Gene

Domains & Families for SRF Gene

Gene Families for SRF Gene

Protein Domains for SRF Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SRF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P11831

UniProtKB/Swiss-Prot:

SRF_HUMAN :
  • Contains 1 MADS-box domain.
Domain:
  • Contains 1 MADS-box domain.
genes like me logo Genes that share domains with SRF: view

Function for SRF Gene

Molecular function for SRF Gene

UniProtKB/Swiss-Prot Function:
SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5 of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation.

Gene Ontology (GO) - Molecular Function for SRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA,IDA 20808827
GO:0005515 protein binding IEA,IPI 8887666
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with SRF: view
genes like me logo Genes that share phenotypes with SRF: view

Animal Models for SRF Gene

MGI Knock Outs for SRF:

Animal Model Products

  • Taconic Biosciences Mouse Models for SRF

Transcription Factor Targets for SRF Gene

Selected GeneGlobe predicted Target genes for SRF
Targeted motifs for SRF Gene
HOMER Transcription Factor Regulatory Elements motif SRF
  • Consensus sequence: CCATATATGGNA Submotif: canonical Cell Type: PUER

No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for SRF Gene

Localization for SRF Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRF Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRF Gene COMPARTMENTS Subcellular localization image for SRF gene
Compartment Confidence
nucleus 5
cytoskeleton 2
plasma membrane 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for SRF Gene

Pathways & Interactions for SRF Gene

genes like me logo Genes that share pathways with SRF: view

SIGNOR curated interactions for SRF Gene

Activates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for SRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEP 19098903
GO:0001701 in utero embryonic development IEA --
GO:0001707 mesoderm formation IEA --
GO:0001764 neuron migration IEA --
GO:0001829 trophectodermal cell differentiation IDA 17576768
genes like me logo Genes that share ontologies with SRF: view

Drugs & Compounds for SRF Gene

(49) Drugs for SRF Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(46) Additional Compounds for SRF Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SRF: view

Transcripts for SRF Gene

mRNA/cDNA for SRF Gene

Unigene Clusters for SRF Gene

Serum response factor (c-fos serum response element-binding transcription factor):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SRF Gene

No ASD Table

Relevant External Links for SRF Gene

GeneLoc Exon Structure for
SRF
ECgene alternative splicing isoforms for
SRF

Expression for SRF Gene

mRNA expression in normal human tissues for SRF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SRF Gene

This gene is overexpressed in Adipocyte (18.2), Fetal gut (15.8), CD8 Tcells (15.8), Fetal heart (10.0), and Prostate (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SRF Gene



SOURCE GeneReport for Unigene cluster for SRF Gene Hs.520140

genes like me logo Genes that share expression patterns with SRF: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SRF Gene

Orthologs for SRF Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SRF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRF 35
  • 98.47 (n)
  • 98.11 (a)
SRF 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SRF 36
  • 98 (a)
OneToOne
SRF 35
  • 93.96 (n)
  • 96.65 (a)
dog
(Canis familiaris)
Mammalia SRF 35
  • 94.52 (n)
  • 96.63 (a)
SRF 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srf 36
  • 97 (a)
OneToOne
Srf 16
Srf 35
  • 94.91 (n)
  • 96.43 (a)
oppossum
(Monodelphis domestica)
Mammalia SRF 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Srf 35
  • 94.58 (n)
  • 96.63 (a)
chicken
(Gallus gallus)
Aves SRF 36
  • 78 (a)
OneToOne
SRF 35
  • 82.11 (n)
  • 86.41 (a)
lizard
(Anolis carolinensis)
Reptilia SRF 36
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia srf-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia srf 35
  • 68.2 (n)
  • 70.55 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13739 35
zebrafish
(Danio rerio)
Actinopterygii SRF (1 of 2) 36
  • 55 (a)
OneToMany
srfa 36
  • 55 (a)
OneToMany
srf 35
srfa 35
  • 67.85 (n)
  • 70.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta bs 36
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea unc-120 36
  • 35 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARG80 36
  • 32 (a)
OneToMany
MCM1 36
  • 33 (a)
OneToMany
ARG80 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3406 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10664 36
  • 42 (a)
OneToOne
Species with no ortholog for SRF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRF Gene

ENSEMBL:
Gene Tree for SRF (if available)
TreeFam:
Gene Tree for SRF (if available)

Paralogs for SRF Gene

No data available for Paralogs for SRF Gene

Variants for SRF Gene

Sequence variations from dbSNP and Humsavar for SRF Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs3730363 -- 43,176,316(+) CAACT(A/G)AAGAA intron-variant
rs4711741 -- 43,176,880(+) AAATT(A/G)GGGAC intron-variant
rs6902679 -- 43,174,535(+) GGGAC(A/T)ACCTT intron-variant
rs9381235 -- 43,170,154(+) ggcca(A/G)agtgg upstream-variant-2KB
rs12202651 -- 43,170,228(+) aggca(A/G)aggtt upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SRF Gene

Variant ID Type Subtype PubMed ID
nsv521730 CNV Loss 19592680
nsv819840 CNV Gain 19587683

Variation tolerance for SRF Gene

Residual Variation Intolerance Score: 20.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRF Gene

HapMap Linkage Disequilibrium report
SRF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRF Gene

Disorders for SRF Gene

MalaCards: The human disease database

(1) MalaCards diseases for SRF Gene - From: GeneCards

Disorder Aliases PubMed IDs
fumarate hydratase deficiency
  • fumarase deficiency
- elite association - COSMIC cancer census association via MalaCards
Search SRF in MalaCards View complete list of genes associated with diseases

Relevant External Links for SRF

Genetic Association Database (GAD)
SRF
Human Genome Epidemiology (HuGE) Navigator
SRF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRF
genes like me logo Genes that share disorders with SRF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SRF Gene

Publications for SRF Gene

  1. Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element. (PMID: 3203386) Norman C. … Treisman R. (Cell 1988) 2 3 4 67
  2. Proliferation of human primary vascular smooth muscle cells depends on serum response factor. (PMID: 20096952) Werth D. … Heidenreich O. (Eur. J. Cell Biol. 2010) 3 23
  3. Serum response factor depletion affects the proliferation of the hepatocellular carcinoma cells HepG2 and JHH6. (PMID: 20144681) Farra R. … Grassi G. (Biochimie 2010) 3 23
  4. The expression and role of serum response factor in papillary carcinoma of the thyroid. (PMID: 19513551) Kim H.J. … Moon W.S. (Int. J. Oncol. 2009) 3 23
  5. Critical role of serum response factor in pulmonary myofibroblast differentiation induced by TGF-beta. (PMID: 19151320) Sandbo N. … Dulin N.O. (Am. J. Respir. Cell Mol. Biol. 2009) 3 23

Products for SRF Gene

Sources for SRF Gene

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