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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SRF Gene

protein-coding   GIFtS: 61
GCID: GC06P043138

Serum Response Factor (C-Fos Serum Response Element-Binding...

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Serum Response Factor (C-Fos Serum Response Element-Binding
Transcription Factor)1 2
MCM12
Serum Response Factor2

External Ids:    HGNC: 112911   Entrez Gene: 67222   Ensembl: ENSG000001126587   OMIM: 6005895   UniProtKB: P118313   

Export aliases for SRF gene to outside databases

Previous GC identifers: GC06P043141 GC06P043185 GC06P043247 GC06P042855


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SRF Gene:
This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is
a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein
binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the
activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation,
apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for
example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors
(TCFs). (provided by RefSeq, Jul 2008)

GeneCards Summary for SRF Gene: 
SRF (serum response factor (c-fos serum response element-binding transcription factor)) is a protein-coding gene. Diseases associated with SRF include rheumatoid nodulosis, and miller fisher syndrome, and among its related super-pathways are MAPK signaling pathway and NGF Pathway. GO annotations related to this gene include transcription factor binding and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: SRF_HUMAN, P11831
Function: SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad
symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Required
for cardiac differentiation and maturation

Gene Wiki entry for SRF (Serum response factor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SRF gene promoter:
         SRF   SRF (504 AA)   MyoD   Nkx2-5   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSRF promoter sequence
   Search SABiosciences Chromatin IP Primers for SRF

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p

SRF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRF gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P043138:  view genomic region     (about GC identifiers)

Start:
43,138,920 bp from pter      End:
43,149,244 bp from pter
Size:
10,325 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SRF_HUMAN, P11831 (See protein sequence)
Recommended Name: Serum response factor  
Size: 508 amino acids; 51593 Da
Subunit: Binds DNA as a multimer, probably a dimer. Interacts with MLLT7/FOXO4, NKX3A and SSRP1. Interacts with
ARID2 and SRFBP1 (By similarity). Forms complexes with ARID2, MYOCD, NKX2-5 and SRFBP1 (By similarity). Forms a
nuclear ternary complex with MKL1 and SCAI. Interacts with LPXN
Subcellular location: Nucleus
3 PDB 3D structures from and Proteopedia for SRF:
1HBX (3D)        1K6O (3D)        1SRS (3D)    
Secondary accessions: Q5T648

Explore the universe of human proteins at neXtProt for SRF: NX_P11831

Explore proteomics data for SRF at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by PRKDC
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P11831

  • SRF Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SRF Protein Expression
    REFSEQ proteins: NP_003122.1  
    ENSEMBL proteins: 
     ENSP00000265354   ENSP00000401320  

    Human Recombinant Protein Products for SRF: 
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    OriGene Protein Over-expression Lysate for SRF
    OriGene MassSpec for SRF 
    OriGene Custom Protein Services for SRF
    GenScript Custom Purified and Recombinant Proteins Services for SRF
    Novus Biologicals SRF Protein
    Novus Biologicals SRF Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SRF 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin IEA--
    GO:0005634nucleus IDA2108863
    GO:0005737cytoplasm TAS15180964

    SRF for ontologies           About GeneDecksing



    SRF Antibody Products: 
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    Abcam antibodies for SRF
    Cloud-Clone Corp. Antibodies for SRF 
    ThermoFisher Antibodies for SRF
    LSBio Antibodies in human, mouse, rat for SRF 

    Assay Products for SRF: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SRF 
    Cloud-Clone Corp. CLIAs for SRF


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR002100 TF_MADSbox

    Graphical View of Domain Structure for InterPro Entry P11831

    ProtoNet protein and cluster: P11831

    1 Blocks protein domain: IPB002100 Transcription factor

    UniProtKB/Swiss-Prot: SRF_HUMAN, P11831
    Similarity: Contains 1 MADS-box domain


    SRF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRF_HUMAN, P11831
    Function: SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad
    symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Required
    for cardiac differentiation and maturation

         Gene Ontology (GO): 5/15 molecular function terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding ISS--
    GO:0000983contributes to RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity IMP18296735
    GO:0001076RNA polymerase II transcription factor binding transcription factor activity IEA--
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA--
    GO:0001228RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription ISS--
         
    SRF for ontologies           About GeneDecksing


    Phenotypes:
         14 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Srf):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  muscle 
     no phenotypic analysis  normal  respiratory system  skeleton 

    SRF for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SRF: Srftm1Nor Srftm2.2Nor Srftm2.3Nor

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SRF 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SRF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SRF 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SRF 

    10/912 SABiosciences Target genes for SRF (see all 912):
    A2ML1 AATK ABCA13 ABCC5 ABCD1 ABCG5 ABCG8 ABHD12 ABLIM1 ABRA

    miRNA
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    miRTarBase miRNAs that target SRF:
    hsa-mir-122 (MIRT000365)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SRF
    8/81 QIAGEN miScript miRNA Assays for microRNAs that regulate SRF (see all 81):
    hsa-miR-642a hsa-miR-371-5p hsa-miR-550a* hsa-miR-877* hsa-miR-149 hsa-miR-376c hsa-miR-200b hsa-miR-564
    SwitchGear 3'UTR luciferase reporter plasmidSRF 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SRF
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRF

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of SRF

    Clone
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    GenScript: all cDNA clones in your preferred vector: SRF (NM_003131)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRF
    Sirion Biotech Customized lentivirus for stable overexpression of SRF 
                         Customized lentivirus expression plasmids for stable overexpression of SRF 

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    Search LifeMap BioReagents cell lines for SRF
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRF


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SRF About   (see all 32)                                                                                              See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2TRKA Signaling
    TRKA Signaling0.75
    NGF Pathway0.75
    3PKC-Theta Pathway
    TCR Signaling0.68
    PDGF Pathway0.39
    4ErbB4 Pathway
    Growth Hormone Signaling0.49
    LPS Stimulated MAPK Signaling0.47
    5PEDF Induced Signaling
    PEDF Induced Signaling0.73

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for SRF
        Development PDGF signaling via MAPK cascades
    Immune response IL-6 signaling pathway

    5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SRF (see all 15)
        Chemokine Signaling
    TRKA Signaling
    Cellular Transformation by HTLV1
    PDGF Pathway
    Signaling Involved in Cardiac Hypertrophy

    2 Cell Signaling Technology (CST) Pathways for SRF
        MAP Kinase Signaling
    Cytoskeletal Signaling

    2 GeneGo (Thomson Reuters) Pathways for SRF
        Immune response IL-6 signaling pathway
    Development PDGF signaling via MAPK cascades

    5/14 BioSystems Pathways for SRF (see all 14)
        MAPK signaling pathway
    Heart Development
    Insulin Signaling
    Serotonin Receptor 4/6/7 and NR3C Signaling
    Serotonin Receptor 2 and ELK-SRF/GATA4 signaling


    3         Kegg Pathways  (Kegg details for SRF):
        MAPK signaling pathway
    HTLV-I infection
    Viral carcinogenesis


    SRF for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SRF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/101 Interacting proteins for SRF (P118311, 2, 3 ENSP000002653544) via UniProtKB, MINT, STRING, and/or I2D (see all 101)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYOD1P151722, 3, ENSP000002500034MINT-15522 MINT-15523 I2D: score=2 STRING: ENSP00000250003
    MKL1Q969V61, 3, ENSP000003478474EBI-493034,EBI-493122 I2D: score=4 STRING: ENSP00000347847
    MKL2Q9ULH71, 3, ENSP000003390864EBI-493034,EBI-493007 I2D: score=3 STRING: ENSP00000339086
    MYOGP151732, 3, ENSP000002416514MINT-16345 MINT-16346 I2D: score=4 STRING: ENSP00000241651
    MYOCDQ8IZQ81, 3, ENSP000003418354EBI-493034,EBI-493384 I2D: score=4 STRING: ENSP00000341835
    About this table

    Gene Ontology (GO): 5/64 biological process terms (GO ID links to tree view) (see all 64):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001569patterning of blood vessels IEA--
    GO:0001666response to hypoxia IEP19098903
    GO:0001701in utero embryonic development ----
    GO:0001707mesoderm formation IEA--
    GO:0001764neuron migration IEA--

    SRF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SRF for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SRF

    10/95 Novoseek inferred chemical compound relationships for SRF gene (see all 95)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mdi-a 60.5 6 11509578 (1), 20071339 (1), 12429848 (1)
    jasplakinolide 51.2 6 17332502 (1), 11502570 (1), 19874818 (1), 15240009 (1)
    ganglioside gq1b 47.4 1 9753137 (1)
    phosphatidylinositol 28.6 3 1939110 (1), 11342553 (1), 11859076 (1)
    cyclic amp 26.2 10 7507831 (1), 9658126 (1), 10342376 (1), 10961986 (1) (see all 8)
    il-12 22 1 9462175 (1)
    mannose 21.1 2 1846001 (1), 9815228 (1)
    thymidine 21 2 8535215 (1), 12704643 (1)
    12-o-tetradecanoylphorbol 13-acetate 14.7 6 1656100 (1), 11980664 (1), 9880563 (1)
    polysulfone 14.5 2 8675359 (1)

    Search CenterWatch for drugs/clinical trials and news about SRF

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SRF gene: 
    NM_003131.2  

    Unigene Cluster for SRF:

    Serum response factor (c-fos serum response element-binding transcription factor)
    Hs.520140  [show with all ESTs]
    Unigene Representative Sequence: AB209128
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265354(uc003oui.3 uc011dvf.2) ENST00000457278
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/81 QIAGEN miScript miRNA Assays for microRNAs that regulate SRF (see all 81):
    hsa-miR-642a hsa-miR-371-5p hsa-miR-550a* hsa-miR-877* hsa-miR-149 hsa-miR-376c hsa-miR-200b hsa-miR-564
    SwitchGear 3'UTR luciferase reporter plasmidSRF 3' UTR sequence
    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector: SRF (NM_003131)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRF
    Sirion Biotech Customized lentivirus for stable overexpression of SRF 
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    Primer
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    Additional mRNA sequence: 

    AB209128.1 AK300467.1 BC048211.1 BC052572.1 J03161.1 

    5 DOTS entries:

    DT.451694  DT.100029210  DT.95131188  DT.100787005  DT.100706306 

    24/255 AceView cDNA sequences (see all 255):

    BG231953 BQ065950 BQ012660 BM970621 BE044291 AA962564 BQ072087 BM972180 
    BM469317 BM698716 BF057535 CA424569 BU616078 CA427771 BQ001805 BU730682 
    BM091479 NM_003131 BM856035 BM992115 BM466600 BF881885 CA442495 CR595609 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SRF expression in normal human tissues (normalized intensities)      SRF embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCACAGTCC
    SRF Expression
    About this image


    SRF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/34 selected tissues (see all 34) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 9 entries
             Vascular Smooth Muscle Cells Coronary Capillary Plexus
             Cardiac progenitor cells
             heart muscle ; myocytes   
     
     Smooth Muscle (Muscoskeletal System)    fully expand to see all 6 entries
             Vascular Smooth Muscle Cells Coronary Capillary Plexus
             smooth muscle ; smooth muscle cells   
     
     Epithelium
             oral mucosa ; squamous epithelial cells   
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             ovary ; follicle cells   
             oocyte   
     
     Epidermis (Integumentary System)    fully expand to see all 3 entries
             Spinous Keratinocytes Stratified Epidermis
             vulva/anal skin ; epidermal cells   

    See SRF Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SRF

    SOURCE GeneReport for Unigene cluster: Hs.520140
        SABiosciences Expression via Pathway-Focused PCR Arrays including SRF: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              Synaptic Plasticity in human mouse rat

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    OriGene qSTAR qPCR primer pairs in human, mouse for SRF
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRF
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SRF gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srf1 , 5 serum response factor1, 5 95.17(n)1
    97.22(a)1
      17 (22.90 cM)5
    208071  NM_020493.21  NP_065239.11 
     465468395 
    chicken
    (Gallus gallus)
    Aves SRF1 serum response factor (c-fos serum response element-binding more 81.18(n)
    84.79(a)
      396103  NM_001252141.1  NP_001239070.1 
    lizard
    (Anolis carolinensis)
    Reptilia SRF6
    Uncharacterized protein
    80(a)
    1 ↔ 1
    2(143872482-143955138)
    African clawed frog
    (Xenopus laevis)
    Amphibia srf-A2 serum response factor 78.45(n)    X56451.1 
    zebrafish
    (Danio rerio)
    Actinopterygii srf2 serum response factor 72.28(n)   30431  BC050480.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta bs1 blistered 53.77(n)
    50.87(a)
      37890  NM_166667.1  NP_726438.1 
    worm
    (Caenorhabditis elegans)
    Secernentea unc-1206
    Protein UNC-120
    34(a)
    1 ↔ 1
    I(8460225-8463014)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ARG80(YMR042W)4 Transcription factor involved in regulation of arginine-responsive more   --   13(352603-353136) 855059  NP_013756.1 


    ENSEMBL Gene Tree for SRF (if available)
    TreeFam Gene Tree for SRF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/202 SNPs in SRF are shown (see all 202)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1426737351,2
    --43136923(+) GTGATA/TCCCAT 1 -- us2k10--------
    rs1473525001,2
    --43137305(+) CATGGC/TGAAAC 1 -- us2k10--------
    rs582309671,2
    C--43137508(+) AAAAA-/A/AA  
            
    CTCAG
    1 -- us2k11NA 2
    rs109480661,2
    C,F,A,H--43137514(+) ACTCAG/TGGAAT 1 -- us2k118Minor allele frequency- T:0.36NS EA WA NA CSA 2339
    rs789752471,2
    C,F--43137545(+) ATTGCG/ATCTGG 1 -- us2k11Minor allele frequency- A:0.10WA 118
    rs2012982731,2
    --43137723(+) TTTAA-/GGTTTT 1 -- us2k10--------
    rs355744241,2
    C,F--43137725(+) TTAAGG/TTTTTT 1 -- us2k12Minor allele frequency- T:0.50WA CSA 4
    rs358820211,2
    C--43137740(+) TTTTT-/T/TT/T
    TTTTTTTT
    TTTTT
    2 -- us2k1 cds11NA 2
    rs69159701,2
    C,A--43137763(+) cacggG/Tggttc 1 -- us2k10--------
    rs93812351,2
    A--43137892(+) ggccaA/Gagtgg 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SRF (43138920 - 43149244 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SRF:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv521730CNV Loss19592680
    nsv819840CNV Gain19587683

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600589    OMIM disorders: --

    20/104 diseases for SRF (see all 104):    About MalaCards
    rheumatoid nodulosis    miller fisher syndrome    fetal alcohol spectrum disorder    rheumatoid vasculitis
    x-linked hyper igm syndrome    eosinophilic gastroenteritis    syringomyelia    lymphangioleiomyomatosis
    rosai-dorfman disease    congenital heart block    guillain-barre syndrome    gastroenteritis
    vasculitis    arthropathy    gastric ulcer    jaundice
    retinal detachment    obstructive jaundice    spondylitis    human t-cell leukemia virus type 1


    SRF for disorders           About GeneDecksing

    10/91 Novoseek inferred disease relationships for SRF gene (see all 91)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rheumatoid arthritis 52.4 13 8849349 (1), 15742441 (1), 1417131 (1), 10716453 (1) (see all 13)
    leukemia t-cell 52.3 14 7933111 (2), 15207639 (1), 17898074 (1), 8361755 (1) (see all 6)
    megakaryoblastic leukemia acute 51.8 1 19136660 (1)
    rheumatoid nodule 44.1 3 8257029 (1), 8833048 (1), 20084988 (1)
    rheumatoid vasculitis 28.9 1 8182655 (1)
    congenital heart block 28.6 2 10402042 (1), 8974073 (1)
    hypertrophy 25 14 10368339 (3), 15221330 (2), 18252708 (1), 16556869 (1) (see all 9)
    lupus erythematosus systemic 23.3 3 2002277 (1), 14872509 (1), 8383027 (1)
    arthritis 23.2 6 10366125 (1), 2066957 (1), 19921094 (1), 8039045 (1) (see all 6)
    autoimmune diseases 21.8 1 14872509 (1)

    Genetic Association Database (GAD): SRF
    Human Genome Epidemiology (HuGE) Navigator: SRF (9 documents)

    Export disorders for SRF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SRF gene, integrated from 9 sources (see all 732):
    (articles sorted by number of sources associating them with SRF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element. (PubMed id 3203386)1, 2, 3 Norman C.... Treisman R. (1988)
    2. The carboxyl-terminal transactivation domain of human serum response factor contains DNA-activated protein kinase phosphorylation sites. (PubMed id 8407951)1, 2, 9 Liu S.-H....Ng S.-Y. (1993)
    3. C-terminal phosphorylation of the serum-response factor. (PubMed id 8375385)1, 2, 9 Janknecht R.... Nordheim A. (1993)
    4. Identification of multiple SRF N-terminal phosphorylation sites affecting DNA binding properties. (PubMed id 1547771)1, 2, 9 Janknecht R....Stunnenberg H.G. (1992)
    5. Localization of O-GlcNAc modification on the serum response transcription factor. (PubMed id 1512232)1, 2, 9 Reason A.J.... Dell A. (1992)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    8. SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin. (PubMed id 19350017)1, 2 Brandt D.T.... Grosse R. (2009)
    9. The LIM protein leupaxin is enriched in smooth muscle and functions as an serum response factor cofactor to induce smooth muscle cell gene transcription. (PubMed id 18497331)1, 2 Sundberg-Smith L.J....Taylor J.M. (2008)
    10. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6722 HGNC: 11291 AceView: SRF Ensembl:ENSG00000112658 euGenes: HUgn6722
    ECgene: SRF Kegg: 6722 H-InvDB: SRF

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SRF Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SRF Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SRF gene:
    Search GeneIP for patents involving SRF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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