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SREK1IP1 Gene

protein-coding   GIFtS: 42
GCID: GC05M064013

SREK1-Interacting Protein 1

(Previous name: SFRS12-interacting protein 1)
(Previous symbol: SFRS12IP1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SREK1-Interacting Protein 11 2 3     P18SRP2 3
SFRS12IP11 2 3     Protein SFRS12IP12
SFRS12-Interacting Protein 11 2 3     Protein SREK1IP12
P18 Splicing Regulatory Protein1 2     p18SRP3
Splicing Regulatory Protein Of 18 KDa2 3     

External Ids:    HGNC: 267161   Entrez Gene: 2856722   Ensembl: ENSG000001530067   UniProtKB: Q8N9Q23   

Export aliases for SREK1IP1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SREK1IP1 Gene:
SREK1IP1 (SREK1-interacting protein 1) is a protein-coding gene. GO annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot: SR1IP_HUMAN, Q8N9Q2
Function: Possible splicing regulator involved in the control of cellular survival




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_034772.7  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SREK1IP1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSREK1IP1 promoter sequence
   Search Chromatin IP Primers for SREK1IP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SREK1IP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q12.3   Ensembl cytogenetic band:  5q12.3   HGNC cytogenetic band: 5q12.3

SREK1IP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SREK1IP1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M064013:  view genomic region     (about GC identifiers)

Start:
64,013,971 bp from pter      End:
64,064,512 bp from pter
Size:
50,542 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SR1IP_HUMAN, Q8N9Q2 (See protein sequence)
Recommended Name: Protein SREK1IP1  
Size: 155 amino acids; 18177 Da
Subunit: Interacts with SREK1/SFRS12
Sequence caution: Sequence=AAI08717.1; Type=Frameshift; Positions=79;
Secondary accessions: Q32NC8

Explore the universe of human proteins at neXtProt for SREK1IP1: NX_Q8N9Q2

Explore proteomics data for SREK1IP1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SREK1IP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_776190.1  
    ENSEMBL proteins: 
     ENSP00000427401  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR001878 Znf_CCHC

    Graphical View of Domain Structure for InterPro Entry Q8N9Q2

    ProtoNet protein and cluster: Q8N9Q2

    1 Blocks protein domain: IPB001878 C2HC-type zinc-finger signature

    UniProtKB/Swiss-Prot: SR1IP_HUMAN, Q8N9Q2
    Similarity: Contains 1 CCHC-type zinc finger


    Find genes that share domains with SREK1IP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SR1IP_HUMAN, Q8N9Q2
    Function: Possible splicing regulator involved in the control of cellular survival
    Induction: Down-regulated in the brains of Alzheimer disease patients

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with SREK1IP1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SREK1IP1:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SREK1IP1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SREK1IP1
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    miRNA
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    miRTarBase miRNAs that target SREK1IP1:
    hsa-mir-935 (MIRT036681), hsa-mir-92a-3p (MIRT049843), hsa-mir-100-5p (MIRT048385), hsa-mir-101-3p (MIRT027283), hsa-let-7d-5p (MIRT032136), hsa-mir-421 (MIRT016115), hsa-mir-26b-5p (MIRT029124)

    Block miRNA regulation of human, mouse, rat SREK1IP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SREK1IP1 (see all 93):
    hsa-miR-548j hsa-miR-376b hsa-miR-3138 hsa-miR-550a* hsa-miR-1304 hsa-miR-149 hsa-miR-1243 hsa-miR-29a*
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SREK1IP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SREK1IP1
    Interactions:

        Search GeneGlobe Interaction Network for SREK1IP1

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0008380RNA splicing IEA--

    Find genes that share ontologies with SREK1IP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SREK1IP1 (SR1IP)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SREK1IP1 gene: 
    NM_173829.3  

    Unigene Cluster for SREK1IP1:

    SREK1-interacting protein 1
    Hs.69504  [show with all ESTs]
    Unigene Representative Sequence: NM_173829
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000513458(uc003jtk.3) ENST00000495198 ENST00000510616 ENST00000506252(uc021xzh.1)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SREK1IP1 (see all 93):
    hsa-miR-548j hsa-miR-376b hsa-miR-3138 hsa-miR-550a* hsa-miR-1304 hsa-miR-149 hsa-miR-1243 hsa-miR-29a*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat SREK1IP1
      QuantiFast Probe-based Assays in human, mouse, rat SREK1IP1

    Additional mRNA sequence: 

    AK094073.1 AL832348.1 BC047006.1 BC108716.1 BC127085.1 BC127086.1 HM370403.1 

    9 DOTS entries:

    DT.108558  DT.441409  DT.312024  DT.100705543  DT.91872451  DT.87015671  DT.95156605  DT.97795106 
    DT.100850039 

    Selected AceView cDNA sequences (see all 158):

    BM976742 AW341526 BG054486 AA251885 BE645776 BM264362 BF223067 AW196758 
    BG221538 AI680602 AI628589 AA321262 CR619130 CA396343 BX499826 BX507007 
    AI392984 AA490478 AW269138 BI962553 AA648477 AA993673 AW183589 AL697878 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SREK1IP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGTCCCAG
    SREK1IP1 Expression
    About this image

    SREK1IP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SREK1IP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.69504
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SREK1IP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SREK1IP1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srek1ip15 splicing regulatory glutamine/lysine-rich protein 1interacting more   --   13 (56.84 cM) 104792484 
    chicken
    (Gallus gallus)
    Aves SREK1IP16
    SREK1-interacting protein 1
    74(a)
    1 ↔ 1
    Z(20059916-20070517)
    lizard
    (Anolis carolinensis)
    Reptilia SREK1IP16
    SREK1-interacting protein 1
    70(a)
    1 ↔ 1
    1(226435334-226451391)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.77762 Xenopus laevis, clone IMAGE4889220, mRNA 79.78(n)    BC044965.1 
    zebrafish
    (Danio rerio)
    Actinopterygii srek1ip16
    SREK1-interacting protein 1
    56(a)
    1 ↔ 1
    10(11360424-11363486) ENSDARG00000043728
    fruit fly
    (Drosophila melanogaster)
    Insecta CG39186
    --
    18(a)
    1 ↔ 1
    X(6418497-6420375)


    ENSEMBL Gene Tree for SREK1IP1 (if available)
    TreeFam Gene Tree for SREK1IP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SREK1IP1 gene

    Find genes that share paralogs with SREK1IP1           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for SREK1IP1
    PGOHUM00000259672 PGOHUM00000260178


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SREK1IP1 (see all 917)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1126249031,2
    C,F--64014536(+) CTAATT/ATCTGC 1 -- ut311Minor allele frequency- A:0.50WA 2
    rs1834157251,2
    --64014607(+) GTTTTA/GTAACA 1 -- ut310--------
    rs798764871,2
    F--64014697(+) CAGAAA/GCTAGC 1 -- ut310--------
    rs1435890261,2
    --64014836(+) CAAAGA/CTCAGG 1 -- ut310--------
    rs1468001951,2
    --64014856(+) TTTTCA/GTCATT 1 -- ut310--------
    rs8982101,2
    C,F,H--64014991(+) gctacT/Cgaaca 1 -- ut319Minor allele frequency- C:0.08MN NS EA NA CSA WA 842
    rs1395808371,2
    C--64015067(+) CCTATA/GTGGCT 1 -- ut310--------
    rs758661411,2
    F--64015177(+) ATTGCT/GTAAAG 1 -- ut311Minor allele frequency- G:0.10WA 118
    rs1428731771,2
    C--64015237(+) TTACAC/TGGCCA 1 -- ut310--------
    rs1510826921,2
    C--64015273(+) TTTTGC/TGAAAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SREK1IP1 (64013971 - 64064512 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SREK1IP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2752074CNV Gain17911159
    dgv6083n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SREK1IP1
    DNA2.0 Custom Variant and Variant Library Synthesis for SREK1IP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SREK1IP1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with SREK1IP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The splicing regulatory protein p18SRP is down-regulated in Alzheimer's disease brain. (PubMed id 15456940)1, 2, 3 Heese K....Sawada T. (J. Mol. Neurosci. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 285672 HGNC: 26716 AceView: FLJ36754 Ensembl:ENSG00000153006 euGenes: HUgn285672
    ECgene: SREK1IP1 H-InvDB: SREK1IP1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SREK1IP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SREK1IP1 gene:
    Search GeneIP for patents involving SREK1IP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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      eBioscience FlowRNA Probe Sets
           
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