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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SREK1IP1 Gene

protein-coding   GIFtS: 41
GCID: GC05M064013

SREK1-interacting protein 1

(Previous name: SFRS12-interacting protein 1 )
(Previous symbol: SFRS12IP1)
 Explore 2 diseases affiliated with
SREK1IP1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SREK1IP1    

Aliases
for SREK1IP1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
SREK1-Interacting Protein 11 2 3     FLJ367541
P18SRP1 2 3     P18 Splicing Regulatory Protein2
SFRS12IP11 2 3     Protein SFRS12IP12
SFRS12-Interacting Protein 11 2 3     Protein SREK1IP12
Splicing Regulatory Protein Of 18 KDa2 3     P18SRP1 2 3

External Ids:    HGNC: 267161   Entrez Gene: 2856722   Ensembl: ENSG000001530067   UniProtKB: Q8N9Q23   

Export aliases for SREK1IP1 gene to outside databases


Summaries
for SREK1IP1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: SR1IP_HUMAN, Q8N9Q2
Function: Possible splicing regulator involved in the control of cellular survival




Genomic Views
for SREK1IP1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006713.15  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SREK1IP1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SREK1IP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SREK1IP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SREK1IP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q12.3   Ensembl cytogenetic band:  5q12.3   HGNC cytogenetic band: 5q12.3

SREK1IP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SREK1IP1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M064013:  view genomic region     (about GC identifiers)

Start:
 64,013,975 bp from pter      End:
 64,064,512 bp from pter
Size:
 50,538 bases      Orientation:
 minus strand

Proteins
for SREK1IP1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SR1IP_HUMAN, Q8N9Q2 (See protein sequence)
Recommended Name: Protein SREK1IP1  
Size: 155 amino acids; 18177 Da
Subunit: Interacts with SREK1/SFRS12
Sequence caution: Sequence=AAI08717.1; Type=Frameshift; Positions=79;
Secondary accessions: Q32NC8

Explore the universe of human proteins at neXtProt for SREK1IP1: NX_Q8N9Q2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8N9Q2

    • SREK1IP1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_776190.1  
    ENSEMBL proteins: 
     ENSP00000427401  

    Human Recombinant Protein Products: 
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    Novus Biologicals SREK1IP1 Lysates
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    Uscn Proteins for SREK1IP1


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    Uscn ELISAs and CLIAs for SREK1IP1

    Protein Domains /
    Families
    for SREK1IP1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SREK1IP1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001878 Znf_CCHC

    Graphical View of Domain Structure for InterPro Entry Q8N9Q2

    ProtoNet protein and cluster: Q8N9Q2

    1 Blocks protein family: IPB001878 C2HC-type zinc-finger signature

    UniProtKB/Swiss-Prot: SR1IP_HUMAN, Q8N9Q2
    Similarity: Contains 1 CCHC-type zinc finger


    Function
    for SREK1IP1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SR1IP_HUMAN, Q8N9Q2
    Function: Possible splicing regulator involved in the control of cellular survival
    Induction: Down-regulated in the brains of Alzheimer disease patients

    miRNA
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    hsa-miR-548j hsa-miR-376b hsa-miR-3138 hsa-miR-550a* hsa-miR-1304 hsa-miR-149 hsa-miR-1243 hsa-miR-29a*
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    Inhib. RNA
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    OriGene shRNA RFP: SREK1IP1
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SREK1IP1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SREK1IP1

    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for SREK1IP1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SREK1IP1

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0008270zinc ion binding IEA--


    SREK1IP1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SREK1IP1:
     Increased gamma-H2AX phosphory 


    Pathways & Interactions
    for SREK1IP1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SREK1IP1

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0008380RNA splicing IEA--


    SREK1IP1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SREK1IP1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SREK1IP1
    Search CenterWatch for drugs/clinical trials and news about SREK1IP1 / SR1IP 

    Transcripts
    for SREK1IP1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SREK1IP1 gene: 
    NM_173829.3  

    Unigene Cluster for SREK1IP1:

    SREK1-interacting protein 1
    Hs.69504  [show with all ESTs]
    Unigene Representative Sequence: NM_173829
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000513458(uc003jtk.3) ENST00000495198 ENST00000510616 ENST00000506252(uc021xzh.1)


    miRNA
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    8/93 QIAGEN miScript miRNA Assays for microRNAs that regulate SREK1IP1 (see all 93):
    hsa-miR-548j hsa-miR-376b hsa-miR-3138 hsa-miR-550a* hsa-miR-1304 hsa-miR-149 hsa-miR-1243 hsa-miR-29a*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SREK1IP1 (see all 4)
    OriGene shRNA RFP: SREK1IP1
    OriGene siRNA: SREK1IP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SREK1IP1
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SREK1IP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SREK1IP1

    Additional cDNA sequence: 

    AK094073.1 AL832348.1 BC047006.1 BC108716.1 BC127085.1 BC127086.1 HM370403.1 

    9 DOTS entries:

    DT.108558  DT.441409  DT.312024  DT.100705543  DT.91872451  DT.87015671  DT.95156605  DT.97795106 
    DT.100850039 

    24/158 AceView cDNA sequences (see all 158):

    AW269138 AW196758 AI392984 AL697878 BX507007 BI962553 AI680602 BF223067 
    BG054486 AA490478 CR619130 BM264362 AA251885 BM976742 AA648477 AW183589 
    BU729898 BE645776 CA396343 AA993673 AW673847 BM264057 CB105121 BX499826 

    GeneLoc Exon Structure


    Expression
    for SREK1IP1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SREK1IP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCAGTCCCAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SREK1IP1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SREK1IP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SREK1IP1

    SOURCE GeneReport for Unigene cluster: Hs.69504
        SABiosciences Custom PCR Arrays for SREK1IP1
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SREK1IP1

    Orthologs
    for SREK1IP1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SREK1IP1 gene from 9/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Srek1ip11 , 5 splicing regulatory glutamine/lysine-rich protein 1interacting more1, 5 86.93(n)1
    90.85(a)1    		   13 (56.84 cM)5
    672881  NM_026075.21  NP_080351.21 
     1047924845 
    chicken
    (Gallus gallus)    		 Aves SREK1IP11 SREK1-interacting protein 1 73.51(n)
    77.48(a)    		   427158  XM_424747.3  XP_424747.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SREK1IP16
    		 --
    		 71(a)
    		 1 ↔ 1
    		 1(226435833-226441583)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.77762 Xenopus laevis, clone IMAGE4889220, mRNA 79.78(n)    BC044965.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii srek1ip11 SREK1-interacting protein 1 63.13(n)
    59.6(a)    		   553315  NM_001037672.1  NP_001032761.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG39181 CG3918 50(n)
    44.52(a)    		   31585  NM_132095.3  NP_572323.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea C13F10.76
    		 Protein C13F10.7
    		 24(a)
    		 1 ↔ 1
    		 V(7222031-7223261)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons CXIP46
    		 CAX-interacting protein 4
    		 11(a)
    		 1 ↔ 1
    		 2(12415780-12417385)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 CAX-interacting protein 4, putative, expressed
    		 14(a)
    12(a)
    		 many → 1
    many → 1
    		 5(13203917-13204810)
    9(455236-456840)


    ENSEMBL Gene Tree for SREK1IP1 (if available)
    TreeFam Gene Tree for SREK1IP1 (if available) 

    Paralogs
    for SREK1IP1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SREK1IP1 gene

    SREK1IP1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for SREK1IP1
    PGOHUM00000259672 PGOHUM00000260178


    Genomic Variants
    for SREK1IP1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/802 NCBI SNPs in SREK1IP1 are shown (see all 802)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1895915231,2
    		--64014134(+) CAGTCC/GTATCT 2 -- ut31 ds50010--------
    rs1822052071,2
    		--64014153(+) AACAGG/TGAGAA 2 -- ut31 ds50010--------
    rs1861796481,2
    		--64014192(+) ACTTTC/TTGATA 2 -- ds5001 ut310--------
    rs1395802441,2
    		--64014360(+) ATCACA/GATGTA 2 -- ds5001 ut310--------
    rs1915752381,2
    		--64014487(+) CCCACA/CTAATG 2 -- ut31 ds50010--------
    rs1493141881,2
    		--64014499(+) TATCAC/TATTAA 2 -- ut31 ds50010--------
    rs1126249031,2
    		C,--64014536(+) CTAATT/ATCTGC 1 -- ut311Minor allele frequency- A:0.50WA 2
    rs1834157251,2
    		--64014607(+) GTTTTA/GTAACA 1 -- ut310--------
    rs798764871,2
    		--64014697(+) CAGAAA/GCTAGC 1 -- ut310--------
    rs1435890261,2
    		--64014836(+) CAAAGA/CTCAGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SREK1IP1 (64013975 - 64064512 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SREK1IP1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SREK1IP1
    DNA2.0 Custom Variant and Variant Library Synthesis for SREK1IP1

    Disorders / Diseases
    for SREK1IP1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SREK1IP1 for disorders           About GeneDecksing

    2 diseases for SREK1IP1:    About MalaCards
    alzheimer's disease    malaria


    Export disorders for SREK1IP1 gene to outside databases

    Publications
    for SREK1IP1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SREK1IP1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SREK1IP1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The splicing regulatory protein p18SRP is down-regulated in Alzheimer's disease brain. (PubMed id 15456940)1, 2, 3 Heese K....Sawada T. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    5. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for SREK1IP1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SREK1IP1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 285672 HGNC: 26716 AceView: FLJ36754 Ensembl:ENSG00000153006 euGenes: HUgn285672
    ECgene: SREK1IP1 H-InvDB: SREK1IP1

    Other Databases showing SREK1IP1 gene

    (According to HUGE)
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    		   --

    Specialized Databases showing SREK1IP1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SREK1IP1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SREK1IP1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SREK1IP1 gene:
    Search GeneIP for patents involving SREK1IP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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