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Aliases for SREK1IP1 Gene

Aliases for SREK1IP1 Gene

  • SREK1 Interacting Protein 1 2 3 5
  • SFRS12-Interacting Protein 1 2 3 4
  • Splicing Regulatory Protein Of 18 KDa 3 4
  • P18 Splicing Regulatory Protein 2 3
  • SREK1-Interacting Protein 1 2 4
  • SFRS12IP1 3 4
  • P18SRP 3 4
  • Protein SFRS12IP1 3
  • Protein SREK1IP1 3

External Ids for SREK1IP1 Gene

Previous HGNC Symbols for SREK1IP1 Gene

  • SFRS12IP1

Previous GeneCards Identifiers for SREK1IP1 Gene

  • GC05M064013

Summaries for SREK1IP1 Gene

GeneCards Summary for SREK1IP1 Gene

SREK1IP1 (SREK1 Interacting Protein 1) is a Protein Coding gene. Diseases associated with SREK1IP1 include Alzheimer Disease. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for SREK1IP1 Gene

  • Possible splicing regulator involved in the control of cellular survival.

Additional gene information for SREK1IP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SREK1IP1 Gene

Genomics for SREK1IP1 Gene

GeneHancer (GH) Regulatory Elements for SREK1IP1 Gene

Promoters and enhancers for SREK1IP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I064765 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 561.8 +1.0 973 4.5 HDGF PKNOX1 CLOCK SMAD1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 SREK1IP1 CWC27 PPWD1 TRAPPC13 SHISAL2B
GH05I065031 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.4 -266.2 -266152 7 HDGF PKNOX1 SMAD1 SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B ZNF766 GC05M065036 PPWD1 SREK1IP1 ADAMTS6 ENSG00000272354
GH05I065478 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.2 -712.3 -712281 6 PKNOX1 FOXA2 SMAD1 SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF213 FOS ADAMTS6 PPWD1 SREK1 CENPK TRAPPC13 ENSG00000250081 SREK1IP1 RPS2P23
GH05I065121 Enhancer 1 ENCODE dbSUPER 11 -353.5 -353548 1.9 ATF1 ARNT ZBTB40 TCF12 ZNF766 EGR1 ATF7 CREM ZBTB11 CEBPB GC05P065124 ENSG00000207439 PPWD1 SREK1IP1 GC05M065036
GH05I064690 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 5.8 +77.9 77949 1.6 ZSCAN4 KLF17 ZNF76 ZNF2 ZNF335 GLIS2 ZNF366 SCRT2 KLF7 EGR2 SHISAL2B SREK1IP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SREK1IP1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SREK1IP1 Gene

Genomic Locations for SREK1IP1 Gene
chr5:64,718,144-64,768,731
(GRCh38/hg38)
Size:
50,588 bases
Orientation:
Minus strand
chr5:64,013,971-64,064,512
(GRCh37/hg19)

Genomic View for SREK1IP1 Gene

Genes around SREK1IP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SREK1IP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SREK1IP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SREK1IP1 Gene

Proteins for SREK1IP1 Gene

  • Protein details for SREK1IP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9Q2-SR1IP_HUMAN
    Recommended name:
    Protein SREK1IP1
    Protein Accession:
    Q8N9Q2
    Secondary Accessions:
    • Q32NC8

    Protein attributes for SREK1IP1 Gene

    Size:
    155 amino acids
    Molecular mass:
    18177 Da
    Quaternary structure:
    • Interacts with SREK1/SFRS12.
    SequenceCaution:
    • Sequence=AAI08717.1; Type=Frameshift; Positions=79; Evidence={ECO:0000305};

neXtProt entry for SREK1IP1 Gene

Post-translational modifications for SREK1IP1 Gene

No Post-translational modifications

Other Protein References for SREK1IP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SREK1IP1 Gene

Domains & Families for SREK1IP1 Gene

Gene Families for SREK1IP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SREK1IP1 Gene

Suggested Antigen Peptide Sequences for SREK1IP1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SREK1IP1: view

No data available for UniProtKB/Swiss-Prot for SREK1IP1 Gene

Function for SREK1IP1 Gene

Molecular function for SREK1IP1 Gene

UniProtKB/Swiss-Prot Function:
Possible splicing regulator involved in the control of cellular survival.
UniProtKB/Swiss-Prot Induction:
Down-regulated in the brains of Alzheimer disease patients.

Phenotypes From GWAS Catalog for SREK1IP1 Gene

Gene Ontology (GO) - Molecular Function for SREK1IP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SREK1IP1: view
genes like me logo Genes that share phenotypes with SREK1IP1: view

miRNA for SREK1IP1 Gene

miRTarBase miRNAs that target SREK1IP1

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SREK1IP1 Gene

Localization for SREK1IP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SREK1IP1 gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SREK1IP1 Gene

Pathways & Interactions for SREK1IP1 Gene

SuperPathways for SREK1IP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SREK1IP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with SREK1IP1: view

No data available for Pathways by source and SIGNOR curated interactions for SREK1IP1 Gene

Drugs & Compounds for SREK1IP1 Gene

No Compound Related Data Available

Transcripts for SREK1IP1 Gene

Unigene Clusters for SREK1IP1 Gene

SREK1-interacting protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SREK1IP1 Gene

No ASD Table

Relevant External Links for SREK1IP1 Gene

GeneLoc Exon Structure for
SREK1IP1
ECgene alternative splicing isoforms for
SREK1IP1

Expression for SREK1IP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SREK1IP1 Gene

Protein differential expression in normal tissues from HIPED for SREK1IP1 Gene

This gene is overexpressed in Platelet (26.8), Fetal heart (16.1), Fetal testis (11.9), and CD8 Tcells (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SREK1IP1 Gene



Protein tissue co-expression partners for SREK1IP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SREK1IP1 Gene:

SREK1IP1

SOURCE GeneReport for Unigene cluster for SREK1IP1 Gene:

Hs.69504

Evidence on tissue expression from TISSUES for SREK1IP1 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with SREK1IP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SREK1IP1 Gene

Orthologs for SREK1IP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SREK1IP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SREK1IP1 33 34
  • 99.57 (n)
dog
(Canis familiaris)
Mammalia SREK1IP1 34
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SREK1IP1 34
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srek1ip1 34
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 85 (a)
OneToMany
-- 34
  • 84 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SREK1IP1 34
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves SREK1IP1 34
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SREK1IP1 34
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17599 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.7776 33
zebrafish
(Danio rerio)
Actinopterygii srek1ip1 34
  • 56 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2618 33
fruit fly
(Drosophila melanogaster)
Insecta CG3918 34
  • 18 (a)
OneToOne
Species where no ortholog for SREK1IP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SREK1IP1 Gene

ENSEMBL:
Gene Tree for SREK1IP1 (if available)
TreeFam:
Gene Tree for SREK1IP1 (if available)

Paralogs for SREK1IP1 Gene

Pseudogenes.org Pseudogenes for SREK1IP1 Gene

genes like me logo Genes that share paralogs with SREK1IP1: view

No data available for Paralogs for SREK1IP1 Gene

Variants for SREK1IP1 Gene

Sequence variations from dbSNP and Humsavar for SREK1IP1 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000024919 -- 64,763,641(-) G/A intron_variant
rs1000025952 -- 64,734,511(-) G/A intron_variant
rs1000073770 -- 64,719,610(-) T/C 3_prime_UTR_variant
rs1000121820 -- 64,770,438(-) A/G upstream_transcript_variant
rs1000140548 -- 64,720,894(-) T/C/G 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for SREK1IP1 Gene

Variant ID Type Subtype PubMed ID
dgv5692n100 CNV gain 25217958
esv2752074 CNV gain 17911159
esv3405338 CNV insertion 20981092
nsv1031566 CNV gain 25217958
nsv598390 CNV gain 21841781

Variation tolerance for SREK1IP1 Gene

Residual Variation Intolerance Score: 69.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.49; 43.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SREK1IP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SREK1IP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SREK1IP1 Gene

Disorders for SREK1IP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SREK1IP1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
alzheimer disease
  • ad
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SREK1IP1

genes like me logo Genes that share disorders with SREK1IP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SREK1IP1 Gene

Publications for SREK1IP1 Gene

  1. The splicing regulatory protein p18SRP is down-regulated in Alzheimer's disease brain. (PMID: 15456940) Heese K … Sawada T (Journal of molecular neuroscience : MN 2004) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131. (PMID: 26841866) Varier RA … Vermeulen M (The Journal of biological chemistry 2016) 3 58
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58

Products for SREK1IP1 Gene

Sources for SREK1IP1 Gene

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