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Aliases for SREK1 Gene

Aliases for SREK1 Gene

  • Splicing Regulatory Glutamine/Lysine-Rich Protein 1 2 3
  • Splicing Factor, Arginine/Serine-Rich 12 2 3 4
  • SRrp508 3 4 6
  • SFRS12 3 4 6
  • Serine-Arginine-Rich Splicing Regulatory Protein 508 2 3
  • Serine/Arginine-Rich-Splicing Regulatory Protein 86 3 4
  • Splicing Regulatory Protein 508 3 4
  • SRrp86 3 4

External Ids for SREK1 Gene

Previous Symbols for SREK1 Gene

  • SFRS12

Summaries for SREK1 Gene

Entrez Gene Summary for SREK1 Gene

  • This gene encodes a member of a family of serine/arginine-rich (SR) splicing proteins containing RNA recognition motif (RRM) domains. The encoded protein interacts with other SR proteins to modulate splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for SREK1 Gene

SREK1 (Splicing Regulatory Glutamine/Lysine-Rich Protein 1) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway. GO annotations related to this gene include nucleotide binding and nucleic acid binding. An important paralog of this gene is SRSF11.

UniProtKB/Swiss-Prot for SREK1 Gene

  • Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 (By similarity).

Gene Wiki entry for SREK1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SREK1 Gene

Genomics for SREK1 Gene

Genomic Location for SREK1 Gene

Start:
66,139,971 bp from pter
End:
66,183,616 bp from pter
Size:
43,646 bases
Orientation:
Plus strand

Genomic View for SREK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SREK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SREK1 Gene

No data available for Regulatory Elements for SREK1 Gene

Proteins for SREK1 Gene

  • Protein details for SREK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXA9-SREK1_HUMAN
    Recommended name:
    Splicing regulatory glutamine/lysine-rich protein 1
    Protein Accession:
    Q8WXA9
    Secondary Accessions:
    • A4FTW3
    • Q2M1J0
    • Q86X37

    Protein attributes for SREK1 Gene

    Size:
    508 amino acids
    Molecular mass:
    59380 Da
    Quaternary structure:
    • Homodimer. Binds SFRS1, SFRS2, SFRS3 and SFRS6. Interacts with the spliceosome (By similarity). Interacts with SREK1IP1.
    SequenceCaution:
    • Sequence=AAH47322.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for SREK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SREK1 Gene

Proteomics data for SREK1 Gene at MOPED

Post-translational modifications for SREK1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SREK1 Gene

Domains for SREK1 Gene

Gene Families for SREK1 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for SREK1 Gene

UniProtKB/Swiss-Prot:

SREK1_HUMAN
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.:
    • Q8WXA9
Family:
  • Belongs to the splicing factor SR family.:
    • Q8WXA9
genes like me logo Genes that share domains with SREK1: view

Function for SREK1 Gene

Molecular function for SREK1 Gene

UniProtKB/Swiss-Prot Function: Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 (By similarity).

Gene Ontology (GO) - Molecular Function for SREK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0005515 protein binding IPI 25416956
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with SREK1: view

miRNA for SREK1 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SREK1 Gene

Localization for SREK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SREK1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SREK1 Gene COMPARTMENTS Subcellular localization image for SREK1 gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytosol 2

Gene Ontology (GO) - Cellular Components for SREK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005681 spliceosomal complex IEA --
GO:0005739 mitochondrion --
GO:0043231 intracellular membrane-bounded organelle --
genes like me logo Genes that share ontologies with SREK1: view

Pathways for SREK1 Gene

SuperPathways for SREK1 Gene

Superpath Contained pathways
1 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with SREK1: view

Pathways by source for SREK1 Gene

1 BioSystems pathway for SREK1 Gene

Gene Ontology (GO) - Biological Process for SREK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with SREK1: view

Transcripts for SREK1 Gene

Unigene Clusters for SREK1 Gene

Splicing regulatory glutamine/lysine-rich protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SREK1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ·
SP1: - - - - -
SP2:
SP3: -
SP4: - - - -
SP5: - -
SP6: - -
SP7: - - -
SP8: -
SP9: -
SP10:
SP11:

ExUns: 17c · 17d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for SREK1 Gene

GeneLoc Exon Structure for
SREK1
ECgene alternative splicing isoforms for
SREK1

Expression for SREK1 Gene

mRNA expression in normal human tissues for SREK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SREK1 Gene

SOURCE GeneReport for Unigene cluster for SREK1 Gene Hs.49367

genes like me logo Genes that share expressions with SREK1: view

Orthologs for SREK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SREK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SREK1 36
  • 99.41 (n)
  • 99.41 (a)
SREK1 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SREK1 36
  • 92.56 (n)
  • 94.75 (a)
SREK1 37
  • 30 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SREK1 36
  • 93.26 (n)
  • 94.74 (a)
SREK1 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srek1 36
  • 88.37 (n)
  • 90 (a)
Srek1 16
Srek1 37
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SREK1 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SREK1 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Srek1 36
  • 87.21 (n)
  • 89.18 (a)
chicken
(Gallus gallus)
Aves SREK1 36
  • 76.05 (n)
  • 74.67 (a)
SREK1 37
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15747 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17421 36
zebrafish
(Danio rerio)
Actinopterygii srek1 37
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Srp54 37
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rsp-7 37
  • 31 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2526 36
Species with no ortholog for SREK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SREK1 Gene

ENSEMBL:
Gene Tree for SREK1 (if available)
TreeFam:
Gene Tree for SREK1 (if available)

Paralogs for SREK1 Gene

Paralogs for SREK1 Gene

Selected SIMAP similar genes for SREK1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for SREK1 Gene

genes like me logo Genes that share paralogs with SREK1: view

Variants for SREK1 Gene

Sequence variations from dbSNP and Humsavar for SREK1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs26994 -- 66,144,726(+) TGGGG(G/T)GTTAA intron-variant, upstream-variant-2KB
rs27046 -- 66,144,136(+) CCCCA(C/G)GGACC upstream-variant-2KB
rs27076 -- 66,154,368(-) AATTA(C/T)ACACC intron-variant
rs27077 -- 66,149,514(+) GTTGC(A/G)TTACA intron-variant
rs27078 -- 66,149,503(+) CTTCA(C/G)ATGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SREK1 Gene

Variant ID Type Subtype PubMed ID
nsv830328 CNV Gain 17160897
esv2661452 CNV Deletion 23128226
esv33447 CNV Loss 17666407

Relevant External Links for SREK1 Gene

HapMap Linkage Disequilibrium report
SREK1
Human Gene Mutation Database (HGMD)
SREK1

Disorders for SREK1 Gene

No disorders were found for SREK1 Gene.

No data available for UniProtKB/Swiss-Prot for SREK1 Gene

Publications for SREK1 Gene

  1. Molecular cloning, characterization, chromosomal assignment, genomic organization and verification of SFRS12(SRrp508), a novel member of human SR protein superfamily and a human homolog of rat SRrp86. (PMID: 12043562) Zhang D.L. … Ma D.L. (Yi Chuan Xue Bao 2002) 2 3 4
  2. Large-scale proteomic analysis of the human spliceosome. (PMID: 12176931) Rappsilber J. … Mann M. (Genome Res. 2002) 3 4
  3. Identification and characterization of a novel serine-arginine-rich splicing regulatory protein. (PMID: 10757789) Barnard D.C. … Patton J.G. (Mol. Cell. Biol. 2000) 3 23
  4. A unique glutamic acid-lysine (EK) domain acts as a splicing inhibitor. (PMID: 12183448) Li J. … Patton J.G. (J. Biol. Chem. 2002) 3 23
  5. The splicing regulatory protein p18SRP is down-regulated in Alzheimer's disease brain. (PMID: 15456940) Heese K. … Sawada T. (J. Mol. Neurosci. 2004) 3 4

Products for SREK1 Gene

  • Addgene plasmids for SREK1

Sources for SREK1 Gene

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