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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SREK1 Gene

protein-coding   GIFtS: 51
GCID: GC05P065435

splicing regulatory glutamine/lysine-rich protein 1

(Previous names: splicing factor, arginine/serine-rich 12 )
(Previous symbol: SFRS12)
 Explore 4 diseases affiliated with
SREK1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SREK1    

Aliases
for SREK1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Splicing Regulatory Glutamine/Lysine-Rich Protein 11 2     Splicing Regulatory Protein 5082 3
SFRS121 2 3 5     DKFZp564B1761
Splicing Factor, Arginine/Serine-Rich 121 2 3     Serine-Arginine-Rich Splicing Regulatory Protein 5082
SRrp5081 2 3     SRRP863
SRrp861 2 3     SRRp5085
Serine/Arginine-Rich-Splicing Regulatory Protein 862 3     

External Ids:    HGNC: 178821   Entrez Gene: 1408902   Ensembl: ENSG000001539147   OMIM: 6092685   UniProtKB: Q8WXA93   

Export aliases for SREK1 gene to outside databases

Previous GC identifer: GC05P062397


Summaries
for SREK1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SREK1:
This gene encodes a member of a family of serine/arginine-rich (SR) splicing proteins containing RNA recognition motif
(RRM) domains. The encoded protein interacts with other SR proteins to modulate splice site selection. Alternatively
spliced transcript variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Jul
2012)

UniProtKB/Swiss-Prot: SREK1_HUMAN, Q8WXA9
Function: Participates in the regulation of alternative splicing by modulating the activity of other splice facors.
Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 (By similarity)

Gene Wiki entry for SREK1 (SFRS12)


Genomic Views
for SREK1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006713.15  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SREK1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SREK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SREK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SREK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q12.3   Ensembl cytogenetic band:  5q12.3   HGNC cytogenetic band: 5q11.2-q12.1

SREK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SREK1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P065435:  view genomic region     (about GC identifiers)

Start:
 65,435,799 bp from pter      End:
 65,479,443 bp from pter
Size:
 43,645 bases      Orientation:
 plus strand

Proteins
for SREK1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SREK1_HUMAN, Q8WXA9 (See protein sequence)
Recommended Name: Splicing regulatory glutamine/lysine-rich protein 1  
Size: 508 amino acids; 59380 Da
Subunit: Homodimer. Binds SFRS1, SFRS2, SFRS3 and SFRS6. Interacts with the spliceosome (By similarity). Interacts with
SREK1IP1
Subcellular location: Nucleus
Sequence caution: Sequence=AAH47322.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A
sequence;
Secondary accessions: A4FTW3 Q2M1J0 Q86X37
Alternative splicing: 2 isoforms:  Q8WXA9-1   Q8WXA9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SREK1: NX_Q8WXA9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8WXA9

    • SREK1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001070667.1  NP_001257421.1  NP_001257422.1  NP_631907.1  

    ENSEMBL proteins: 
     ENSP00000428272   ENSP00000334538   ENSP00000427935   ENSP00000428970   ENSP00000370305  
     ENSP00000430894  

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    Browse Proteins at Uscn

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005681spliceosomal complex IEA--
    GO:0005730NOT nucleolus IDA--
    GO:0005739mitochondrion IDA--
    GO:0043231intracellular membrane-bounded organelle IDA--


    SREK1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for SREK1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SREK1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q8WXA9

    ProtoNet protein and cluster: Q8WXA9

    1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: SREK1_HUMAN, Q8WXA9
    Similarity: Belongs to the splicing factor SR family
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    Function
    for SREK1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SREK1_HUMAN, Q8WXA9
    Function: Participates in the regulation of alternative splicing by modulating the activity of other splice facors.
    Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 (By similarity)

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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding IEA--


    SREK1 for ontologies           About GeneDecksing



    Pathways & Interactions
    for SREK1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1mRNA Splicing - Major Pathway
    		mRNA processing0.48


    1 BioSystems Pathway for SREK1 
        mRNA processing


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SREK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/569 Interacting proteins for SREK1 (Q8WXA92, 3 ENSP000003345384) via UniProtKB, MINT, STRING, and/or I2D (see all 569)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SRSF7Q166292, 3, ENSP000003259054MINT-7947479 I2D: score=3 STRING: ENSP00000325905
    DDX17Q928412, 3, ENSP000003800334MINT-7947479 I2D: score=2 STRING: ENSP00000380033
    HNRNPH1P319432, 3, ENSP000003491684MINT-7947479 I2D: score=2 STRING: ENSP00000349168
    NPM1P067482, 3, ENSP000002969304MINT-7947479 I2D: score=2 STRING: ENSP00000296930
    PARP1P098742, 3, ENSP000003557594MINT-7947479 I2D: score=2 STRING: ENSP00000355759
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0008380RNA splicing IEA--


    SREK1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SREK1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for SREK1
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    Transcripts
    for SREK1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SREK1 gene (4 alternative transcripts): 
    NM_001077199.2  NM_001270492.1  NM_001270493.1  NM_139168.3  

    Unigene Cluster for SREK1:

    Splicing regulatory glutamine/lysine-rich protein 1
    Hs.49367  [show with all ESTs]
    Unigene Representative Sequence: NM_139168
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000521691 ENST00000334121(uc003jun.3 uc010iwy.3 uc003juo.3)
    ENST00000523851 ENST00000520058 ENST00000522912 ENST00000520953 ENST00000524111(uc003jum.3)
    ENST00000380918 ENST00000284041 ENST00000518110 ENST00000520580 ENST00000519259
    ENST00000523655 ENST00000522214 ENST00000519205

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    hsa-miR-548j hsa-miR-361-5p hsa-let-7d hsa-miR-4272 hsa-miR-219-5p hsa-miR-218 hsa-miR-507 hsa-miR-508-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SREK1 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AK091758.1 AK125893.1 AK308287.1 AL049309.1 BC017000.1 BC047322.1 BC067770.1 BC112343.1 

    23 DOTS entries:

    DT.100036511  DT.121644533  DT.95368229  DT.100679550  DT.203982  DT.92058765  DT.106453  DT.100036510 
    DT.100776701  DT.100681090  DT.306912  DT.438233  DT.95136293  DT.95366075  DT.101969373  DT.86821271 
    DT.91766436  DT.100794810  DT.120835812  DT.92048993  DT.95256050  DT.99995759  DT.95121101 

    24/241 AceView cDNA sequences (see all 241):

    NM_139168 F11425 BM013999 AI299893 BQ005434 BG547111 BF221753 AI911738 
    BX483972 BE302388 AW082409 BM709746 AI590596 AA576855 F09090 BC047322 
    AI434010 BU675768 AI886030 AW303506 AA938392 AA620761 AX747166 N72758 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for SREK1 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ·
    SP1:                    -           -     -     -     -                                                                                                         
    SP2:                                                                                                                                                            
    SP3:                                            -                                                                                                               
    SP4:                    -           -     -     -                                                                                                               
    SP5:                                                                                                                          -           -                     

    ExUns: 17c · 17d
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for SREK1

    Expression
    for SREK1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SREK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCTTTAATAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See SREK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SREK1

    SOURCE GeneReport for Unigene cluster: Hs.49367
        SABiosciences Custom PCR Arrays for SREK1
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    In Situ
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    Orthologs
    for SREK1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SREK1 gene from 7/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Srek11 , 5 splicing regulatory glutamine/lysine-rich protein 11, 5 88.37(n)1
    90.2(a)1    		   13 (56.16 cM)5
    2185431  NM_172592.21  NP_766180.11 
     1037416155 
    chicken
    (Gallus gallus)    		 Aves SREK11 splicing regulatory glutamine/lysine-rich protein 1 78.44(n)
    78.55(a)    		   427168  XM_424756.3  XP_424756.3 
    lizard
    (Anolis carolinensis)    		 Reptilia SREK16
    		 --
    		 75(a)
    		 1 ↔ 1
    		 2(11008270-11042265)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.157472 Xenopus laevis transcribed sequence with weak similarity more 77.86(n)    BJ069201.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii srek11 splicing regulatory glutamine/lysine-rich protein 1 61.86(n)
    65.57(a)    		   445219  NM_001003613.1  NP_001003613.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Srp541 CG4602-PA 41.68(n)
    39.63(a)    		   34312  NM_057999.4  NP_477347.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea rsp-71 Protein RSP-7 44.85(n)
    39.71(a)    		   174646  NM_171033.3  NP_741039.1 


    ENSEMBL Gene Tree for SREK1 (if available)
    TreeFam Gene Tree for SREK1 (if available) 

    Paralogs
    for SREK1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SREK1 gene
    LUC7L2  SRSF112  RSRC22  LUC7L32  ZC3H132  LUC7L22  PNISR2  RBM252  
    PRPF38B2  TRAF3IP12  
    4 SIMAP similar genes for SREK1 using alignment to 5 protein entries:     SREK1_HUMAN (see all proteins):
    DKFZp667P103    SFRS11    SRSF11    DKFZp686P22142

    SREK1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SREK1
    PGOHUM00000256707


    Genomic Variants
    for SREK1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/693 NCBI SNPs in SREK1 are shown (see all 693)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs270811,2
    		C,F,A,H,--65438155(-) TTAACA/CTAATG 3 -- us2k1 tfbs316Minor allele frequency- C:0.16NS EA NA CSA WA 2148
    rs133554861,2
    		C,--65438225(+) tgataA/Caatat 3 -- us2k13Minor allele frequency- C:0.30WA 122
    rs780407571,2
    		F,--65438281(+) CAAACC/ATTTTT 3 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1163599941,2
    		--65438361(+) TTGTAG/AGTCCA 3 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1402953231,2
    		--65438393(+) TACATA/GGATAA 3 -- us2k10--------
    rs1492677381,2
    		--65438410(+) GTCAT-/GGGGGT 3 -- us2k10--------
    rs751185471,2
    		C--65438465(+) ATAGTT/AATCTT 3 -- us2k12Minor allele frequency- A:0.25NA 4
    rs1503614591,2
    		--65438509(+) TCAAGC/TAGACC 3 -- us2k10--------
    rs133604311,2
    		C,--65438563(+) gtattC/Tgatct 3 -- us2k12Minor allele frequency- T:0.21WA 120
    rs1831362771,2
    		--65438567(+) TCGATC/GTGTTG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for SREK1 (65435799 - 65479443 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SREK1: --
    Human Gene Mutation Database (HGMD): SREK1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SREK1
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    Disorders / Diseases
    for SREK1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SREK1 for disorders           About GeneDecksing

    OMIM gene information: 609268    OMIM disorders: --

    4 diseases for SREK1:    About MalaCards
    alzheimer's disease    malaria    mantle cell lymphoma    leukemia


    Export disorders for SREK1 gene to outside databases

    Publications
    for SREK1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SREK1 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with SREK1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, characterization, chromosomal assignment, genomic organization and verification of SFRS12(SRrp508), a novel member of human SR protein superfamily and a human homolog of rat SRrp86. (PubMed id 12043562)1, 2, 3 Zhang D.L.... Ma D.L. (2002)
    2. The splicing regulatory protein p18SRP is down-regulated in Alzheimer's disease brain. (PubMed id 15456940)1, 2 Heese K....Sawada T. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Large-scale proteomic analysis of the human spliceosome. (PubMed id 12176931)1, 2 Rappsilber J.... Mann M. (2002)
    5. A unique glutamic acid-lysine (EK) domain acts as a splicing inhibitor. (PubMed id 12183448)1, 9 Li J....Patton J.G. (2002)
    6. Identification and characterization of a novel serine-arginine-rich splicing regulatory protein. (PubMed id 10757789)1, 9 Barnard D.C. and Patton J.G. (2000)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Analysis of SRrp86-regulated alternative splicing: co ntrol of c-Jun and II_BI^ activity. (PubMed id 20400856)1 Solis A.S. and Patton J.G. (2010)
    9. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)

    External Searches for SREK1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    Genome Databases showing SREK1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 140890 HGNC: 17882 AceView: SFRS12 Ensembl:ENSG00000153914 euGenes: HUgn140890
    ECgene: SREK1 H-InvDB: SREK1

    Other Databases showing SREK1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SREK1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SREK1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SREK1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SREK1 gene:
    Search GeneIP for patents involving SREK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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