Aliases for SRD5A3 Gene
External Ids for SRD5A3 Gene
Previous GeneCards Identifiers for SRD5A3 Gene
The protein encoded by this gene belongs to the steroid 5-alpha reductase family, and polyprenol reductase subfamily. It is involved in the production of androgen 5-alpha-dihydrotestosterone (DHT) from testosterone, and maintenance of the androgen-androgen receptor activation pathway. This protein is also necessary for the conversion of polyprenol into dolichol, which is required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-linked glycosylation of proteins. Mutations in this gene are associated with congenital disorder of glycosylation type Iq. [provided by RefSeq, Mar 2011]
GeneCards Summary for SRD5A3 Gene
SRD5A3 (Steroid 5 Alpha-Reductase 3) is a Protein Coding gene. Diseases associated with SRD5A3 include kahrizi syndrome and congenital disorder of glycosylation, type iq. Among its related pathways are Metabolism and Transport to the Golgi and subsequent modification. GO annotations related to this gene include oxidoreductase activity, acting on the CH-CH group of donors and 3-oxo-5-alpha-steroid 4-dehydrogenase activity.
UniProtKB/Swiss-Prot for SRD5A3 Gene
Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).