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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SRD5A3 Gene

protein-coding   GIFtS: 55
GCID: GC04P056212

steroid 5 alpha-reductase 3
 Explore 11 diseases affiliated with
SRD5A3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SRD5A3    

Aliases
for SRD5A3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Steroid 5 Alpha-Reductase 31 2     CDG1P2
SRD5A2L1 2 3 5     KRIZI2
SRD5A2L11 2     Polyprenol Reductase2
3-Oxo-5-Alpha-Steroid 4-Dehydrogenase 32 3     Probable Polyprenol Reductase2
S5AR 32 3     EC 1.3.1.223
SR Type 32 3     EC 1.3.1.943
CDG1Q2 5     Steroid 5-Alpha-Reductase 2-Like3
FLJ133521     Steroid 5-Alpha-Reductase 33

External Ids:    HGNC: 258121   Entrez Gene: 796442   Ensembl: ENSG000001280397   OMIM: 6117155   UniProtKB: Q9H8P03   

Export aliases for SRD5A3 gene to outside databases

Previous GC identifers: GC04P055908 GC04P052161


Summaries
for SRD5A3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SRD5A3:
The protein encoded by this gene belongs to the steroid 5-alpha reductase family, and polyprenol reductase subfamily.
It is involved in the production of androgen 5-alpha-dihydrotestosterone (DHT) from testosterone, and maintenance of
the androgen-androgen receptor activation pathway. This protein is also necessary for the conversion of polyprenol
into dolichol, which is required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide
precursor used for N-linked glycosylation of proteins. Mutations in this gene are associated with congenital disorder
of glycosylation type Iq. (provided by RefSeq, Mar 2011)

UniProtKB/Swiss-Prot: PORED_HUMAN, Q9H8P0
Function: Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of
polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the
oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the
alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T)
into 5-alpha-dihydrotestosterone (DHT)

Gene Wiki entry for SRD5A3


Genomic Views
for SRD5A3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_022853.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SRD5A3 gene promoter:
         RP58   Pax-5   AML1a   ATF-2   NCX/Ncx   FOXD1   HNF-3beta   CREB   CRE-BP1   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SRD5A3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SRD5A3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRD5A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q12   Ensembl cytogenetic band:  4q12   HGNC cytogenetic band: 4q12

SRD5A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRD5A3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P056212:  view genomic region     (about GC identifiers)

Start:
 56,212,276 bp from pter      End:
 56,239,263 bp from pter
Size:
 26,988 bases      Orientation:
 plus strand

Proteins
for SRD5A3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PORED_HUMAN, Q9H8P0 (See protein sequence)
Recommended Name: Polyprenol reductase  
Size: 318 amino acids; 36521 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (Probable)
Secondary accessions: Q4W5Q6

Explore the universe of human proteins at neXtProt for SRD5A3: NX_Q9H8P0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H8P0

    • SRD5A3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_078868.1  
    ENSEMBL proteins: 
     ENSP00000264228   ENSP00000424714  
    Reactome Protein details: Q9H8P0
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    Browse Proteins at Uscn

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005783endoplasmic reticulum IDA--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral to membrane IEA--


    SRD5A3 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for SRD5A3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SRD5A3 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001104 3-oxo-5_a-steroid_4-DH_C

    Graphical View of Domain Structure for InterPro Entry Q9H8P0

    ProtoNet protein and cluster: Q9H8P0

    1 Blocks protein family: IPB001104 3-oxo-5-alpha-steroid 4-dehydrogenase

    UniProtKB/Swiss-Prot: PORED_HUMAN, Q9H8P0
    Similarity: Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily


    Function
    for SRD5A3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PORED_HUMAN, Q9H8P0
    Function: Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of
    polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the
    oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the
    alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T)
    into 5-alpha-dihydrotestosterone (DHT)
    Catalytic activity: Ditrans,polycis-dolichol + NADP(+) = ditrans,polycis-polyprenol + NADPH
    Catalytic activity: A 3-oxo-5-alpha-steroid + NADP(+) = a 3-oxo-Delta(4)-steroid + NADPH

    Enzyme Numbers (IUBMB): EC 1.3.1.941 EC 1.3.1.221

    miRNA
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    hsa-let-7d hsa-miR-3942-5p hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-1255a hsa-miR-4326 hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SRD5A3 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00038653-oxo-5-alpha-steroid 4-dehydrogenase activity IDA17986282
    GO:0016627oxidoreductase activity, acting on the CH-CH group of donors ----
    GO:0016628oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor IDA--
    GO:0047751cholestenone 5-alpha-reductase activity IEA--
    GO:0050213progesterone 5-alpha-reductase activity ----


    SRD5A3 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for SRD5A3:
     Increased G2M DNA content  Increased number of mitotic ce  Synthetic lethal with Ras 

    Animal Models:
         5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Srd5a3):
     cardiovascular system  embryogenesis  growth/size  mortality/aging  nervous system 

    SRD5A3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SRD5A3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Metabolism
    		Metabolism1.00
    		Metabolism of lipids and lipoproteins0.34
    2Vitamin D (calciferol) metabolism
    		Steroid hormones0.27
    		Metabolism of steroid hormones and vitamin D0.27
    3Androgen biosynthesis
    		Androgen biosynthesis1.00
    4dolichol and dolichyl phosphate biosynthesis
    		dolichol and dolichyl phosphate biosynthesis1.00
    5Steroid hormone biosynthesis
    		Steroid hormone biosynthesis1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for SRD5A3 
        dolichol and dolichyl phosphate biosynthesis

    5        Reactome Pathways for SRD5A3
        Metabolism of steroid hormones and vitamin D
    Metabolism
    Steroid hormones
    Androgen biosynthesis
    Metabolism of lipids and lipoproteins


    1         Kegg Pathway  (Kegg details for SRD5A3):
        Steroid hormone biosynthesis

    UniProtKB/Swiss-Prot: PORED_HUMAN, Q9H8P0
    Pathway: Protein modification; protein glycosylation


    SRD5A3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SRD5A3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/35 Interacting proteins for SRD5A3 (Q9H8P03 ENSP000002642284) via UniProtKB, MINT, STRING, and/or I2D (see all 35)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    UNC119Q134323I2D: score=5 
    AKR1C3ENSP000003699274STRING: ENSP00000369927
    AKR1C4ENSP000002631264STRING: ENSP00000263126
    AKR1D1ENSP000002423754STRING: ENSP00000242375
    CGAENSP000003585954STRING: ENSP00000358595
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006486protein glycosylation IEA--
    GO:0006488dolichol-linked oligosaccharide biosynthetic process IMP--
    GO:0006629lipid metabolic process ----
    GO:0006702androgen biosynthetic process TAS--
    GO:0008202steroid metabolic process TAS--


    SRD5A3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SRD5A3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for SRD5A3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    FinasterideType II 5alpha-reductase inhibitor[98319-26-7]

    1 HMDB Compound for SRD5A3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Testosterone(+)-testosterone (see all 86)58-22-0--
    Search CenterWatch for drugs/clinical trials and news about SRD5A3 / PORED 

    Transcripts
    for SRD5A3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SRD5A3 gene: 
    NM_024592.4  

    Unigene Cluster for SRD5A3:

    Steroid 5 alpha-reductase 3
    Hs.39311  [show with all ESTs]
    Unigene Representative Sequence: NM_024592
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264228(uc003hau.3) ENST00000505210 ENST00000514398

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    hsa-let-7d hsa-miR-3942-5p hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-1255a hsa-miR-4326 hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SRD5A3 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AK023414.1 BC002480.2 CR457312.1 

    8 DOTS entries:

    DT.215821  DT.438383  DT.100776172  DT.40246531  DT.100023513  DT.100717619  DT.100683832  DT.215822 

    24/124 AceView cDNA sequences (see all 124):

    CK823753 BU174286 CR602749 BM976846 BG749408 AA252300 AA136831 BM510827 
    AA588683 CR457312 BQ892637 CF126903 CR594439 BU679863 BU634451 CB129001 
    CR622639 BI819702 AI580837 BC002480 CR613723 CB216689 BU196374 AI858981 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SRD5A3 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b
    SP1:                    -     -     -                 -                                 
    SP2:                                -                 -                                 
    SP3:                                                  -                                 
    SP4:                    -     -     -     -     -     -                                 
    SP5:                    -           -                                                   


    ECgene alternative splicing isoforms for SRD5A3

    Expression
    for SRD5A3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SRD5A3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCAGTGCCAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See SRD5A3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SRD5A3

    SOURCE GeneReport for Unigene cluster: Hs.39311

    UniProtKB/Swiss-Prot: PORED_HUMAN, Q9H8P0
    Tissue specificity: Overexpressed in hormone-refractory prostate cancers (HRPC). Almost no or little expression in
    normal adult organs

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    In Situ
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    Orthologs
    for SRD5A3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SRD5A3 gene from 9/27 species (see all 27)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Srd5a31 , 5 steroid 5 alpha-reductase 31, 5 80.71(n)1
    80.82(a)1    		   5 (40.50 cM)5
    573571  NM_020611.41  NP_065636.21 
     761402715 
    chicken
    (Gallus gallus)    		 Aves SRD5A31 steroid 5 alpha-reductase 3 65.88(n)
    59.73(a)    		   422750  XM_420703.3  XP_420703.2 
    lizard
    (Anolis carolinensis)    		 Reptilia SRD5A36
    		 --
    		 54(a)
    		 1 ↔ 1
    		 5(104729310-104738011)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC539832 hypothetical protein MGC53983 74.91(n)    BC042255.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii srd5a31 steroid 5 alpha-reductase 3 53.36(n)
    46.64(a)    		   560717  NM_001044939.1  NP_001038404.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG78401 CG7840 45.05(n)
    31.14(a)    		   34136  NM_135359.2  NP_609203.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea B0024.131 Protein B0024.13 42.84(n)
    28.52(a)    		   179438  NM_001026170.1  NP_001021341.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT2G165306
    AT1G725906
    		 3-oxo-5-alpha-steroid 4-dehydrogenase 3
    		 26(a)
    25(a)
    		 many → 1
    many → 1
    		 2(7162976-7165323)
    1(27335601-27337072)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 3-oxo-5-alpha-steroid 4-dehydrogenase, putative, e...
    3-oxo-5-alpha-steroid 4-dehydrogenase, putative, e...
    		 26(a)
    25(a)
    		 many → 1
    many → 1
    		 4(28886677-28891132)
    7(18426892-18430437)


    ENSEMBL Gene Tree for SRD5A3 (if available)
    TreeFam Gene Tree for SRD5A3 (if available) 

    Paralogs
    for SRD5A3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SRD5A3 gene

    SRD5A3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SRD5A3
    PGOHUM00000258593


    Genomic Variants
    for SRD5A3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Human Gene Mutation Database (HGMD): SRD5A3
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SRD5A3
    DNA2.0 Custom Variant and Variant Library Synthesis for SRD5A3

    Disorders / Diseases
    for SRD5A3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SRD5A3 for disorders           About GeneDecksing

    OMIM gene information: 611715   
    OMIM disorders: 612379  
    UniProtKB/Swiss-Prot: PORED_HUMAN, Q9H8P0
  • Defects in SRD5A3 are the cause of congenital disorder of glycosylation type 1Q (CDG1Q) [MIM:612379]. It is a
    • multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum
    glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in
    the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and
    immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic
    development, differentiation, and maintenance of cell functions
  • Defects in SRD5A3 are the cause of Kahrizi syndrome (KHRZ) [MIM:612713]. An autosomal recessive
    • neurodevelopmental disorder characterized by mental retardation, cataracts, coloboma, kyphosis, and coarse facial
    features

    11 diseases for SRD5A3:    About MalaCards
    congenital disorder of glycosylation    morbid obesity    transsexualism    coloboma
    hypotonia    obesity    prostate cancer    cholesterol
    prostatitis    hepatitis    malaria

    2 diseases from the University of Copenhagen DISEASES database for SRD5A3:
    Transsexualism     Coloboma

    Export disorders for SRD5A3 gene to outside databases

    Publications
    for SRD5A3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SRD5A3 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with SRD5A3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer. (PubMed id 17986282)1, 2, 3 Uemura M....Nakagawa H. (2008)
    2. Next generation sequencing in a family with autosomal recessive Kahrizi syndrome (OMIM 612713) reveals a homozygous frameshift mutat ion in SRD5A3. (PubMed id 20700148)1, 2 Kahrizi K....Tzschach A. (2011)
    3. SRD5A3 is required for converting polyprenol to dolic hol and is mutated in a congenital glycosylation disorder. (PubMed id 20637498)1, 2 Cantagrel V....Gleeson J.G. (2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. SRD5A3-CDG: A patient with a novel mutation. (PubMed id 22240719)2 Kasapkara C.S.... Jaeken J. (2012)
    6. Overexpression of hepatic 5I+-reductase and 11I^-hydrox ysteroid dehydrogenase type 1 in visceral adipose tissue is associated with hyp erinsulinemia in morbidly obese patients. (PubMed id 21704348)1 Baudrand R....Fardella C.E. (2011)
    7. A novel cerebello-ocular syndrome with abnormal glyco sylation due to abnormalities in dolichol metabolism. (PubMed id 20852264)1 Morava E....Lefeber D.J. (2010)
    8. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    9. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    External Searches for SRD5A3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
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    Genome Databases showing SRD5A3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79644 HGNC: 25812 AceView: FLJ13352 Ensembl:ENSG00000128039 euGenes: HUgn79644
    ECgene: SRD5A3 Kegg: 79644 H-InvDB: SRD5A3

    Other Databases showing SRD5A3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SRD5A3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SRD5A3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SRD5A3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SRD5A3 gene:
    Search GeneIP for patents involving SRD5A3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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