Aliases for SRD5A2 Gene
External Ids for SRD5A2 Gene
Previous GeneCards Identifiers for SRD5A2 Gene
This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH). [provided by RefSeq, Jul 2008]
GeneCards Summary for SRD5A2 Gene
SRD5A2 (Steroid 5 Alpha-Reductase 2) is a Protein Coding gene. Diseases associated with SRD5A2 include Pseudovaginal Perineoscrotal Hypospadias and Steroid 5-Alpha-Reductase Deficiency. Among its related pathways are Transcription Androgen Receptor nuclear signaling and Metabolism of steroid hormones. GO annotations related to this gene include oxidoreductase activity, acting on the CH-CH group of donors and cholestenone 5-alpha-reductase activity. An important paralog of this gene is SRD5A1.
UniProtKB/Swiss-Prot for SRD5A2 Gene
Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.