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SRD5A2 Gene

protein-coding GIFtS: 66

GC02M031661

steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 1.3.99.5 ^³
MGC138457 ^²

Descriptions
3-oxo-5 alpha-steroid 4-dehydrogenase 2 ^²
5 alpha-SR2 ^³
SR type 2 ^³
Steroid 5-alpha-reductase 2 ^², ³
Type II 5-alpha reductase ^³
steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) ^²

External Ids
HGNC: 11285¹
Entrez Gene: 6716²
UniProtKB: P31213³
Ensembl: ENSG00000049319⁷

Search outside databases for aliases for SRD5A2 gene

Previous GC identifers: GC02M031693 GC02M031876 GC02M031724

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for SRD5A2:

This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such

as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid

inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism,

specifically pseudovaginal perineoscrotal hypospadias (PPSH). [provided by RefSeq]

UniProtKB/Swiss-Prot: S5A2_HUMAN, P31213

Function: Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or

corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual

differentiation and androgen physiology

Gene Wiki entry for SRD5A2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the SRD5A2 gene

Entrez Gene cytogenetic band: 2p23 Ensembl cytogenetic band: 2p23.1 HGNC cytogenetic band: 2p23.1

SRD5A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M031661: (about GC identifiers)

Start:	31,601,054 bp from pter
End:	31,659,640 bp from pter
Size:	58,587 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000002.10 NT_022184.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: S5A2_HUMAN, P31213 (See protein sequence)

Recommended Name: 3-oxo-5-alpha-steroid 4-dehydrogenase 2

Size: 254 amino acids; 28393 Da

Subcellular location: Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum

membrane; Multi-pass membrane protein (Potential)

Secondary accessions: Q2M1R4 Q9BYE6

REFSEQ proteins: NP_000339.2

ENSEMBL proteins:

ENSP00000233139 ENSP00000384846

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (SRD5A2)
	Human Recombinant Proteins from Abnova (SRD5A2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005783	endoplasmic reticulum	IEA	--
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0005792	microsome	IEA	--
GO:0016020	membrane	IEA	--

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Antibodies for SRD5A2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for SRD5A2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (SRD5A2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (SRD5A2)
	Novus Biologicals Antibodies for SRD5A2

Assays for SRD5A2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P31213

ProtoNet protein and cluster: P31213

2 Blocks protein families:

IPB001104 3-oxo-5-alpha-steroid 4-dehydrogenase

IPB001497 Methylated-DNA-[protein]-cysteine S-methyltransferase

UniProtKB/Swiss-Prot: S5A2_HUMAN, P31213

Similarity: Belongs to the steroid 5-alpha reductase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SRD5A2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SRD5A2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000348

Applied Biosystems Silencer® siRNAs for SRD5A2

Sigma-Aldrich siRNA and siRNA Panels for SRD5A2

Sigma-Aldrich shRNA for SRD5A2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000348
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000348
untagged cDNA clone in CMV expression vector: NM_000348

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000348

UniProtKB/Swiss-Prot: S5A2_HUMAN, P31213

Function: Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or

corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual

differentiation and androgen physiology

Catalytic activity: A 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-Delta(4)-steroid + reduced

acceptor

Biophysicochemical properties: pH dependence: Optimally active at acidic pHs;

Enzyme Number (IUBMB): EC 1.3.99.5

Genatlas biochemistry entry for SRD5A2:

steroid 5 alpha-reductase (3-oxo-5 alpha-steroid delta 4-dehydrogenase) alpha polypeptide 2,genital

tissue,mutated in the prostate cancer in progression

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Srd5a2):

endocrine/exocrine gland

reproductive system

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003865	3-oxo-5-alpha-steroid 4-dehydrogenase activity	IEA	--
GO:0009917	sterol 5-alpha reductase activity	IDA	1944596

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for SRD5A2 (Your Favorite Gene powered by Ingenuity)

Bile Acid Biosynthesis
Androgen and Estrogen Metabolism

GeneDecks SRD5A2 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for SRD5A2

5/29 Interacting proteins for SRD5A2 (ENSP00000233139³) via UniProtKB, MINT, and/or STRING (see all 29 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CYP19A1	ENSP00000260433³	STRING (score=.98)
HSD3B2	ENSP00000358424³	STRING (score=.972)
HSD17B3	ENSP00000364412³	STRING (score=.967)
HSD3B1	ENSP00000358421³	STRING (score=.964)
UGT2B17	ENSP00000320401³	STRING (score=.94)

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5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006629	lipid metabolic process	IEA	--
GO:0007267	cell-cell signaling	TAS	1944596
GO:0007530	sex determination	IEA	--
GO:0008209	androgen metabolic process	IDA	1944596
GO:0008584	male gonad development	IMP	1944596

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for SRD5A2:

Inhibitor

Compounds for SRD5A2 available from Tocris Bioscience

Compound	Action	CAS number
Finasteride	Type II 5alpha-reductase inhibitor	[98319-26-7]

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10/13 Novoseek chemical compound relationships for SRD5A2 gene (see all 13 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
steroid	65.65	38	10469617 (2), 10718838 (2), 15477877 (2), 11340572 (2) (see all 27)
5alpha-dihydroprogesterone	57.96	1	7593415 (1)
17beta-hydroxysteroid	57.63	4	11534997 (1), 16174723 (1), 18410552 (1)
leucine	54.18	16	11164181 (2), 11259089 (1), 10469617 (1), 10606227 (1) (see all 10)
3beta-hydroxysteroid	53.93	5	17823934 (1), 8737913 (1), 10688862 (1), 10905384 (1) (see all 5)
rsai	42.05	1	8751382 (1)
threonine	34.38	5	12815006 (1), 16018939 (1), 11588134 (1), 12712437 (1) (see all 5)
deoxyribonucleic acid	29.21	2	16500352 (1), 10368476 (1)
nadph	25.73	1	10898110 (1)
p005	15.96	1	16039774 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SRD5A2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SRD5A2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000348

Sigma-Aldrich siRNA and siRNA Panels for SRD5A2

Sigma-Aldrich shRNA for SRD5A2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000348

REFSEQ mRNAs for SRD5A2 gene:

NM_000348.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000348

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000348
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000348
                                 untagged cDNA clone in CMV expression vector: NM_000348

Additional cDNA sequence:

AK307235.1 AK316597.1 BC112252.1 BC113641.1 EF560740.1 M74047.1

3 DOTS entries:

DT.306183 DT.120992969 DT.120992970

24/43 AceView cDNA sequences (see all 43 ):

BM699748 AL043257 BM681045 AL565638 BF726287 BM727083 AI791965 BM670868

AA688297 CB163994 BG287020 BE646207 NM_000348 BM693728 BX104882 AA588861

BF437415 AI684088 BX411244 AI924631 BM727607 BU689755 BU736986 M74047

highest scoring ESTs for SRD5A2:

M74047 AA905010 AA912115 AI420552 AI432604 AI476589 AI620211 AI924631 AI969930 AL534740

Unigene Cluster for SRD5A2:

Steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)

Hs.458345 [show with all ESTs]

Unigene Representative Sequence: NM_000348

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for SRD5A2

ExUns:	1	^	2	^	3	^	4	^	5	^	6a	·	6b
SP1:			-
SP2:							-		-

About this scheme

ECgene alternative splicing isoforms for SRD5A2

2 Ensembl transcripts including schematic representations:

ENST00000233139 ENST00000405650

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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SRD5A2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for SRD5A2

¹ / ² / ³

6 probe-sets matching SRD5A2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
565_at²^{, 3}	U95-A	1	1.00	1.00	0.98	0.65	M74047	1.00	1.00	1.00	1
74502_at²	U95-E	1	0.94	1.00	0.94	1.55	--	--	--	--	--
206938_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000348	0.60	1.00	0.82	1
235945_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
206938_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
235945_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks SRD5A2 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.458345
Expression variation in blood from EXPOLDB for SRD5A2
UniProtKB/Swiss-Prot: S5A2_HUMAN, P31213
Tissue specificity: Expressed in high levels in the prostate and many other androgen-sensitive
tissues

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for SRD5A2 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	SRD5A2¹	--	steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 more	88.32(n) 84.25(a)	403715 XM_532922.2 XP_532922.2
cow (Bos taurus)	SRD5A2¹	--	steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 more	89.63(n) 85.83(a)	527024 XM_605410.3 XP_605410.2
rat (Rattus norvegicus)	Srd5a2¹	--	steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 more	80.58(n) 77.56(a)	64677 NM_022711.3 NP_073202.1
mouse (Mus musculus)	Srd5a2^{1, 5}	17⁵	steroid 5 alpha-reductase 2^{1, 5}	81.1(n)¹ 75.2(a)¹	94224¹ NM_053188.2¹ NP_444418.1¹ AB049455⁵ AB049456⁵ (see all 7)
chicken (Gallus gallus)	SRD5A2¹	--	steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 more	68.78(n) 65.87(a)	772291 XM_001235446.1 XP_001235447.1

About this table Species with no ortholog for SRD5A2

ENSEMBL Gene Tree for SRD5A2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for SRD5A2 gene

SRD5A1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: S5A2_HUMAN, P31213

Polymorphism: Individuals with Thr-49 have an increased risk of prostate cancer. The enzyme with

Thr-49 has a higher in vitro V(max) than the Ala-49 enzyme

10/438 NCBI SNPs in SRD5A2 are shown (see all 438 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 168)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs523349^1,2	A,C,F,H	31659210(+)	`ATGTAC/GGCAGA`	1	L/V	mis¹ ese³		17	MN CSAM EA NA NS EU WA	1124
	rs806645^1,2	A,C,F,H	31661444(+)	`CATGAC/TACCAT`	1	--	ng3¹		10	MN EU EA WA	2506
--	rs1042578^1,2	A,C,F,H	31603218(-)	`AAAATG/ACAAAT`	1	--	ut3¹		12	NA NS EU EA WA	738
	rs632148^1,2	C,F,H	31659535(+)	`CAACCG/CCTTTA`	1	--	ut5¹		14	MN CSAM EA NS EU WA	946
	rs9332975^1,2	C,F,H	31603921(-)	`AAACTA/GGTGGC`	1	--	ut3¹ ese³		20	NA NS EU EA WA	1588
--	rs9332964^1,2	C,F	31607899(-)	`GCTGCG/AAGCTT`	1	Q/R	mis¹ ese³		6	EA MN CSAM	406
	rs9332963^1,2	F,H	31607908(-)	`TTTCCT/ATGGGC`	1	H/L	mis¹ ese³		5	EA EU WA	424
	rs9332961^1,2	F,H	31607972(-)	`GGATCG/AGCTAT`	1	S/G	mis¹		5	EA EU WA	430
--	rs10529926^1,2	C,F	31604678(+)	`TATAC-/ATATATAT ATATATATATGGGAC`	1	--	ut3¹		5	NS	188
--	rs9282858^1,2	C,F	31659330(-)	`TGCCAA/GCCCRC`	1	A/T	mis¹ ese³		10	MN CSAM EA NS	576

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HapMap Linkage Disequilibrium images for SRD5A2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 607306 disorders: 264600

UniProtKB/Swiss-Prot: S5A2_HUMAN, P31213

Defects in SRD5A2 are the cause of pseudovaginal perineoscrotal hypospadias (PPSH)

[MIM:264600]; also known as male pseudohermaphroditism due to 5-alpha-reductase deficiency or

5-ARD deficiency. PPSH is a rare form of male pseudohermaphroditism in which affected males

develop normal internal urogenital tracts but fail to develop external male structures.

Individuals with PPSH have testicles and tend to have a vagina and labia, but with a small penis

capable of ejaculation instead of a clitoris (this penis, however, appears to be a clitoris at

birth). These individuals are normally raised as girls. However at puberty their testes will

descend, their voice will deepen and they often will develop a male sexual identity. They develop

only limited facial hair and will not experience male-pattern baldness. Jeffrey Eugenides won a

Pulitzer prize for his 2003 novel 'Middlesex' which describes the life an individual with such a

deficiency

10/19 Novoseek disease relationships for SRD5A2 gene (see all 19 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
pseudohermaphroditism male	91.22	15	16098368 (2), 17551467 (2), 1944596 (1), 8751382 (1) (see all 10)
prostate cancer	77.55	98	11588134 (5), 12949937 (5), 12746845 (5), 16018939 (4) (see all 53)
pseudohermaphroditism	73.88	2	18097518 (1), 8723114 (1)
virilization	73.82	7	8723114 (2), 14739525 (1), 15813602 (1), 16181229 (1) (see all 6)
micropenis	73.16	11	15201804 (4), 12843198 (4), 15266301 (1)
benign prostatic hyperplasia	64.74	9	16018939 (2), 16039774 (1), 16029630 (1), 15136785 (1) (see all 8)
hypospadias	62.76	12	10514539 (3), 15266301 (2), 16736621 (2), 16174723 (1) (see all 5)
androgen insensitivity syndrome	58.70	1	10905384 (1)
somatic mutations	42.84	2	10081907 (2)
aggressiveness	41.34	3	14991867 (2), 17823934 (1)

About this table

Genatlas disease: SRD5A2

hypospadias,pseudovaginal,perineoscrotal;male pseudohermaphroditism

Human Gene Mutation Database: SRD5A2
Genetic Association Database: SRD5A2
Human Genome Epidemiology Navigator: SRD5A2 (83 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/191 PubMed articles for SRD5A2 gene (see all 191 ):

Micropenis and the 5alpha-reductase-2 (SRD5A2) gene: mutation and V89L polymorphism analysis in 81 Japanese patients. (PubMed id 12843198)^{1, 3, 4, 6} Sasaki G.... Matsuo N. (2003)
Association of mis-sense substitution in SRD5A2 gene with prostate cancer in African-American and Hispanic men in Los Angeles, USA. (PubMed id 10501358)^{1, 3, 4, 6} Makridakis N.M.... Reichardt J.K.V. (1999)
Molecular genetics of steroid 5 alpha-reductase 2 deficiency. (PubMed id 1522235)^{1, 2, 3, 4} Thigpen A.E....Russell D.W. (1992)
Evaluation of SRD5A2 sequence variants in susceptibility to hereditary and sporadic prostate cancer. (PubMed id 12746845)^{1, 3, 6} Chang B.L....Xu J. (2003)
Clinical, biochemical and morphologic diagnostic markers in an infant male pseudohermaphrodite patient with compound heterozygous mutations (G115D/R246W) in SRD5A2 gene. (PubMed id 15528927)^{1, 3, 4} Fernandez-Cancio M.... Audi L. (2004)
A common polymorphism within the steroid 5-alpha-reductase type 2 gene and timing of menopause in Caucasian women. (PubMed id 16325991)^{1, 3, 6} Huber A....Hefler L.A. (2006)
Testosterone enanthate therapy is effective and independent of SRD5A2 and AR gene polymorphisms in boys with micropenis. (PubMed id 15201804)^{1, 3, 6} Ishii T....Ogata T. (2004)
Ethnic differences in the frequency of prostate cancer susceptibility alleles at SRD5A2 and CYP3A4. (PubMed id 12446983)^{1, 3, 6} Zeigler-Johnson C.M....Rebbeck T.R. (2002)
Polymorphic markers in the SRD5A2 gene and prostate cancer risk: a population-based case-control study. (PubMed id 11588134)^{1, 3, 6} Hsing A.W....Reichardt J.K. (2001)
Associations between polymorphisms in the steroid 5-alpha reductase type II (SRD5A2) gene and benign prostatic hyperplasia and prostate cancer. (PubMed id 16018939)^{1, 3, 6} Salam M.T....Reichardt J.K. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6716	HGNC: 11285	AceView: SRD5A2	Ensembl:ENSG00000049319	euGenes: HUgn6716
ECgene: SRD5A2	H-InvDB: SRD5A2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for SRD5A2	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.genetests.org/query?gene=SRD5A2
NIEHS-SNPs	http://egp.gs.washington.edu/data/srd5a2/
Wikipedia	http://en.wikipedia.org/wiki/5_alpha_reductase

Licensable Technologies for SRD5A2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for SRD5A2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for SRD5A2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for SRD5A2		Antibodies for SRD5A2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for SRD5A2		Small molecules for SRD5A2
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (SRD5A2)
	Antibodies (SRD5A2)
	Chimera RNAi (SRD5A2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (SRD5A2)
	Antibodies (SRD5A2)

Search OriGene for SRD5A2

Tocris compounds for SRD5A2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for SRD5A2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
SRD5A2 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

SRD5A2 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for SRD5A2

Summaries
for SRD5A2

Genomic Location
for SRD5A2

Proteins
for SRD5A2

Protein Domains/
Families
for SRD5A2

Gene Function
for SRD5A2

Pathways & Interactions
for SRD5A2

Drugs & Compounds
for SRD5A2

Transcripts
for SRD5A2

Expression
for SRD5A2

Orthologs
for SRD5A2

Paralogs
for SRD5A2

SNPs/Variants
for SRD5A2

Disorders & Mutations
for SRD5A2

Medical News
for SRD5A2

Publications
for SRD5A2

Search for SRD5A2

Genome Databases showing SRD5A2

Other Databases showing SRD5A2

Specialized Databases showing SRD5A2

Licensable Technologies
for SRD5A2

Services
for SRD5A2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

SRD5A2 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor SRD5A2

Summariesfor SRD5A2

Genomic Locationfor SRD5A2

Proteinsfor SRD5A2

Protein Domains/Familiesfor SRD5A2

Gene Functionfor SRD5A2

Pathways & Interactionsfor SRD5A2

Drugs & Compoundsfor SRD5A2

Transcriptsfor SRD5A2

Expression for SRD5A2

Orthologsfor SRD5A2

Paralogsfor SRD5A2

SNPs/Variantsfor SRD5A2

Disorders & Mutationsfor SRD5A2

Medical Newsfor SRD5A2

Publicationsfor SRD5A2

Search for SRD5A2

Genome Databases showing SRD5A2

Other Databases showing SRD5A2

Specialized Databases showing SRD5A2

Licensable Technologiesfor SRD5A2

Servicesfor SRD5A2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for SRD5A2

Summaries
for SRD5A2

Genomic Location
for SRD5A2

Proteins
for SRD5A2

Protein Domains/
Families
for SRD5A2

Gene Function
for SRD5A2

Pathways & Interactions
for SRD5A2

Drugs & Compounds
for SRD5A2

Transcripts
for SRD5A2

Expression
for SRD5A2

Orthologs
for SRD5A2

Paralogs
for SRD5A2

SNPs/Variants
for SRD5A2

Disorders & Mutations
for SRD5A2

Medical News
for SRD5A2

Publications
for SRD5A2

Licensable Technologies
for SRD5A2

Services
for SRD5A2