Aliases for SRD5A2 Gene
External Ids for SRD5A2 Gene
Previous GeneCards Identifiers for SRD5A2 Gene
This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH). [provided by RefSeq, Jul 2008]
GeneCards Summary for SRD5A2 Gene
SRD5A2 (Steroid-5-Alpha-Reductase, Alpha Polypeptide 2 (3-Oxo-5 Alpha-Steroid Delta 4-Dehydrogenase Alpha 2)) is a Protein Coding gene. Diseases associated with SRD5A2 include steroid 5-alpha-reductase deficiency and 46,xy disorder of sex development due to 5-alpha-reductase 2 deficiency. Among its related pathways are Glioma and Metabolism. GO annotations related to this gene include oxidoreductase activity, acting on the CH-CH group of donors and cholestenone 5-alpha-reductase activity.
UniProtKB/Swiss-Prot for SRD5A2 Gene
Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology