Aliases for SRD5A2 Gene
External Ids for SRD5A2 Gene
Previous GeneCards Identifiers for SRD5A2 Gene
This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH). [provided by RefSeq, Jul 2008]
GeneCards Summary for SRD5A2 Gene
SRD5A2 (Steroid 5 Alpha-Reductase 2) is a Protein Coding gene. Diseases associated with SRD5A2 include Pseudovaginal Perineoscrotal Hypospadias and Penis Agenesis. Among its related pathways are Transcription Androgen Receptor nuclear signaling and Metabolism. GO annotations related to this gene include oxidoreductase activity, acting on the CH-CH group of donors and cholestenone 5-alpha-reductase activity. An important paralog of this gene is SRD5A1.
UniProtKB/Swiss-Prot for SRD5A2 Gene
Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.