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Aliases for SRD5A1 Gene

Aliases for SRD5A1 Gene

  • Steroid-5-Alpha-Reductase, Alpha Polypeptide 1 (3-Oxo-5 Alpha-Steroid Delta 4-Dehydrogenase Alpha 1) 2 3
  • Steroid 5-Alpha-Reductase 1 4
  • EC 1.3.1.22 4
  • SR Type 1 4
  • S5AR 1 4

External Ids for SRD5A1 Gene

Summaries for SRD5A1 Gene

Entrez Gene Summary for SRD5A1 Gene

  • Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306).[supplied by OMIM, Mar 2008]

GeneCards Summary for SRD5A1 Gene

SRD5A1 (Steroid-5-Alpha-Reductase, Alpha Polypeptide 1 (3-Oxo-5 Alpha-Steroid Delta 4-Dehydrogenase Alpha 1)) is a Protein Coding gene. Diseases associated with SRD5A1 include chronic laryngitis and 5-alpha reductase deficiency. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include electron carrier activity and cholestenone 5-alpha-reductase activity.

UniProtKB/Swiss-Prot for SRD5A1 Gene

  • Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology

Gene Wiki entry for SRD5A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRD5A1 Gene

Genomics for SRD5A1 Gene

Genomic Location for SRD5A1 Gene

Start:
6,633,343 bp from pter
End:
6,669,562 bp from pter
Size:
36,220 bases
Orientation:
Plus strand

Genomic View for SRD5A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SRD5A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRD5A1 Gene

Regulatory Elements for SRD5A1 Gene

Proteins for SRD5A1 Gene

  • Protein details for SRD5A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18405-S5A1_HUMAN
    Recommended name:
    3-oxo-5-alpha-steroid 4-dehydrogenase 1
    Protein Accession:
    P18405
    Secondary Accessions:
    • B2R7Q1
    • Q9UHY4
    • Q9UP36
    • Q9UP37

    Protein attributes for SRD5A1 Gene

    Size:
    259 amino acids
    Molecular mass:
    29459 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SRD5A1 Gene

Proteomics data for SRD5A1 Gene at MOPED

Post-translational modifications for SRD5A1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SRD5A1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SRD5A1 Gene

Domains for SRD5A1 Gene

Suggested Antigen Peptide Sequences for SRD5A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P18405

UniProtKB/Swiss-Prot:

S5A1_HUMAN
Family:
  • Belongs to the steroid 5-alpha reductase family.:
    • P18405
genes like me logo Genes that share domains with SRD5A1: view

No data available for Gene Families for SRD5A1 Gene

Function for SRD5A1 Gene

Molecular function for SRD5A1 Gene

GENATLAS Biochemistry: steroid 5 alpha-reductase (3-oxo-5 alpha-steroid delta 4-dehydrogenase) alpha polypeptide 1,catalyzing the conversion of testosterone to dihydrotestosterone
UniProtKB/Swiss-Prot BiophysicochemicalProperties: pH dependence: Optimally active at alkaline pHs.;
UniProtKB/Swiss-Prot CatalyticActivity: A 3-oxo-5-alpha-steroid + NADP(+) = a 3-oxo-Delta(4)-steroid + NADPH
UniProtKB/Swiss-Prot Function: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology
UniProtKB/Swiss-Prot Induction: Its expression is regulated by androgens such as testosterone

Enzyme Numbers (IUBMB) for SRD5A1 Gene

Gene Ontology (GO) - Molecular Function for SRD5A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003865 3-oxo-5-alpha-steroid 4-dehydrogenase activity IDA 17986282
GO:0009055 electron carrier activity TAS 1686016
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors --
GO:0047751 cholestenone 5-alpha-reductase activity IEA --
genes like me logo Genes that share ontologies with SRD5A1: view

Phenotypes for SRD5A1 Gene

genes like me logo Genes that share phenotypes with SRD5A1: view

Animal Models for SRD5A1 Gene

MGI Knock Outs for SRD5A1:

miRNA for SRD5A1 Gene

miRTarBase miRNAs that target SRD5A1

No data available for Transcription Factor Targeting and HOMER Transcription for SRD5A1 Gene

Localization for SRD5A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRD5A1 Gene

Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRD5A1 Gene COMPARTMENTS Subcellular localization image for SRD5A1 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
cytosol 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SRD5A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SRD5A1: view

Pathways for SRD5A1 Gene

genes like me logo Genes that share pathways with SRD5A1: view

Interacting Proteins for SRD5A1 Gene

Gene Ontology (GO) - Biological Process for SRD5A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process --
GO:0006702 androgen biosynthetic process TAS --
GO:0007530 sex determination NAS 1686016
GO:0007548 sex differentiation IEA --
GO:0008202 steroid metabolic process TAS --
genes like me logo Genes that share ontologies with SRD5A1: view

Compounds for SRD5A1 Gene

(3) Tocris Compounds for SRD5A1 Gene

Compound Action Cas Number
Auranofin Thioredoxin reductase inhibitor; induces MPT [34031-32-8]
ES 936 Mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase (NQO1) [192820-78-3]
Finasteride Type II 5alpha-reductase inhibitor [98319-26-7]

(9) HMDB Compounds for SRD5A1 Gene

Compound Synonyms Cas Number PubMed IDs
7a,12a-Dihydroxy-5a-cholestan-3-one
  • 7a,12a-Dihydroxy-5a-cholestan-3-one
Not Available
7a,12a-Dihydroxy-cholestene-3-one
  • 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one
Not Available
Androst-5-ene-3b,17b-diol
  • 3beta,17beta-Dihydroxy-5-androstene
521-17-5
Androstanedione
  • 5a-Androsta-3,17-dione
846-46-8
Androstenedione
  • (4)-Androsten-3,17-dione
63-05-8

(3) Drugbank Compounds for SRD5A1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Dutasteride
164656-23-9 target inhibitor
Finasteride
  • Finasterida [INN-Spanish]
98319-26-7 target inhibitor
Levonorgestrel
  • 18-Methylnorethisterone
797-63-7 target inhibitor

(102) Novoseek inferred chemical compound relationships for SRD5A1 Gene

Compound -log(P) Hits PubMed IDs
finasteride 97.7 151
dutasteride 96.4 69
dihydrotestosterone 96 127
testosterone 91 169
mk 386 90.2 1
genes like me logo Genes that share compounds with SRD5A1: view

Transcripts for SRD5A1 Gene

Unigene Clusters for SRD5A1 Gene

Steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SRD5A1 Gene

No ASD Table

Relevant External Links for SRD5A1 Gene

GeneLoc Exon Structure for
SRD5A1
ECgene alternative splicing isoforms for
SRD5A1

Expression for SRD5A1 Gene

mRNA expression in normal human tissues for SRD5A1 Gene

mRNA differential expression in normal tissues according to GTEx for SRD5A1 Gene

This gene is overexpressed in Esophagus - Mucosa (4.8) and Liver (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SRD5A1 Gene

SOURCE GeneReport for Unigene cluster for SRD5A1 Gene Hs.552

mRNA Expression by UniProt/SwissProt for SRD5A1 Gene

P18405-S5A1_HUMAN
Tissue specificity: Liver and prostate (at a low level)
genes like me logo Genes that share expressions with SRD5A1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SRD5A1 Gene

Orthologs for SRD5A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SRD5A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRD5A1 35
  • 99.61 (n)
  • 100 (a)
SRD5A1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SRD5A1 35
  • 76.46 (n)
  • 69.44 (a)
SRD5A1 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRD5A1 35
  • 79.1 (n)
  • 73.02 (a)
SRD5A1 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srd5a1 35
  • 72.13 (n)
  • 63.2 (a)
Srd5a1 16
Srd5a1 36
  • 62 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SRD5A1 36
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRD5A1 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Srd5a1 35
  • 71.66 (n)
  • 62.35 (a)
chicken
(Gallus gallus)
Aves SRD5A1 35
  • 65.22 (n)
  • 54.15 (a)
SRD5A1 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRD5A1 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia srd5a1 35
  • 57.66 (n)
  • 52.42 (a)
zebrafish
(Danio rerio)
Actinopterygii srd5a1 35
  • 56.59 (n)
  • 53.88 (a)
srd5a1 36
  • 51 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F19H6.4 36
  • 38 (a)
OneToMany
F42F12.3 36
  • 41 (a)
OneToMany
ZK1251.3 36
  • 31 (a)
OneToMany
ZK1251.3 37
  • 33 (a)
F42F12.3 37
  • 43 (a)
F19H6.4 37
  • 40 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons DET2 35
  • 51.25 (n)
  • 45.79 (a)
rice
(Oryza sativa)
Liliopsida Os01g0851600 35
  • 48.23 (n)
  • 39.38 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC9.08c 35
  • 47.6 (n)
  • 39.3 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8786 36
  • 40 (a)
OneToOne
Species with no ortholog for SRD5A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRD5A1 Gene

ENSEMBL:
Gene Tree for SRD5A1 (if available)
TreeFam:
Gene Tree for SRD5A1 (if available)

Paralogs for SRD5A1 Gene

Selected SIMAP similar genes for SRD5A1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for SRD5A1 Gene

genes like me logo Genes that share paralogs with SRD5A1: view

No data available for Paralogs for SRD5A1 Gene

Variants for SRD5A1 Gene

Sequence variations from dbSNP and Humsavar for SRD5A1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs3296 -- 6,668,736(+) GAGGC(C/T)GGGGG utr-variant-3-prime, nc-transcript-variant
rs3297 -- 6,668,729(-) CCTCT(A/G)TGGCC utr-variant-3-prime, nc-transcript-variant
rs13974 -- 6,668,887(+) AGCCC(A/G)GCCCA utr-variant-3-prime, nc-transcript-variant
rs39848 -- 6,669,649(-) ACAGA(A/G)GAAGT downstream-variant-500B
rs166050 -- 6,643,734(+) tcacc(A/G)ttgat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRD5A1 Gene

Variant ID Type Subtype PubMed ID
nsv880892 CNV Loss 21882294
nsv4696 CNV Insertion 18451855
esv275079 CNV Gain+Loss 21479260

Relevant External Links for SRD5A1 Gene

HapMap Linkage Disequilibrium report
SRD5A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRD5A1 Gene

Disorders for SRD5A1 Gene

(77) Novoseek inferred disease relationships for SRD5A1 Gene

Disease -log(P) Hits PubMed IDs
benign prostatic hyperplasia 94.4 119
pseudohermaphroditism male 85.6 16
alopecia androgenetic 82.8 15
prostate cancer 78.7 128
virilization 76.5 9

Relevant External Links for SRD5A1

Genetic Association Database (GAD)
SRD5A1
Human Genome Epidemiology (HuGE) Navigator
SRD5A1
genes like me logo Genes that share disorders with SRD5A1: view

No data available for UniProtKB/Swiss-Prot for SRD5A1 Gene

Publications for SRD5A1 Gene

  1. Analysis of genetic polymorphisms of steroid 5alpha-reductase type 1 and 2 genes in Korean men with androgenetic alopecia. (PMID: 12670724) Ha S.J. … Kim J.W. (J. Dermatol. Sci. 2003) 3 23 48
  2. Variants in the 5alpha-reductase type 1 and type 2 genes are associated with polycystic ovary syndrome and the severity of hirsutism in affected women. (PMID: 16849416) Goodarzi M.O. … Azziz R. (J. Clin. Endocrinol. Metab. 2006) 3 23 48
  3. Androgenic correlates of genetic variation in the gene encoding 5alpha-reductase type 1. (PMID: 16155734) Ellis J.A. … Harrap S.B. (J. Hum. Genet. 2005) 3 23 48
  4. New steroid 5alpha-reductase type I (SRD5A1) homologous sequences on human chromosomes 6 and 8. (PMID: 11678334) Eminovic I. … Komel R. (Pflugers Arch. 2001) 3 4 23
  5. Gene analysis of steroid 5 alpha-reductase 1 in hyperandrogenic women. (PMID: 16100771) EminoviA8 I. … HeljiA8 B. (Croat. Med. J. 2005) 3 23 48

Products for SRD5A1 Gene

Sources for SRD5A1 Gene

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