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Aliases for SRD5A1 Gene

Aliases for SRD5A1 Gene

  • Steroid 5 Alpha-Reductase 1 2 3
  • Steroid-5-Alpha-Reductase, Alpha Polypeptide 1 (3-Oxo-5 Alpha-Steroid Delta 4-Dehydrogenase Alpha 1) 2 5
  • 3-Oxo-5-Alpha-Steroid 4-Dehydrogenase 1 2
  • Steroid 5-Alpha-Reductase 1 4
  • EC 1.3.1.22 4
  • SR Type 1 4
  • S5AR 1 4

External Ids for SRD5A1 Gene

Previous GeneCards Identifiers for SRD5A1 Gene

  • GC05P006782
  • GC05P006666
  • GC05P006686

Summaries for SRD5A1 Gene

Entrez Gene Summary for SRD5A1 Gene

  • Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306).[supplied by OMIM, Mar 2008]

GeneCards Summary for SRD5A1 Gene

SRD5A1 (Steroid 5 Alpha-Reductase 1) is a Protein Coding gene. Diseases associated with SRD5A1 include Prostatic Adenoma and Prostate Disease. Among its related pathways are Transcription Androgen Receptor nuclear signaling and Metabolism of steroid hormones. GO annotations related to this gene include electron carrier activity and 3-oxo-5-alpha-steroid 4-dehydrogenase activity. An important paralog of this gene is SRD5A2.

UniProtKB/Swiss-Prot for SRD5A1 Gene

  • Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.

Tocris Summary for SRD5A1 Gene

Gene Wiki entry for SRD5A1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRD5A1 Gene

Genomics for SRD5A1 Gene

Regulatory Elements for SRD5A1 Gene

Enhancers for SRD5A1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SRD5A1 on UCSC Golden Path with GeneCards custom track

Promoters for SRD5A1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SRD5A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SRD5A1 Gene

Chromosome:
5
Start:
6,633,343 bp from pter
End:
6,674,386 bp from pter
Size:
41,044 bases
Orientation:
Plus strand

Genomic View for SRD5A1 Gene

Genes around SRD5A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRD5A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRD5A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRD5A1 Gene

Proteins for SRD5A1 Gene

  • Protein details for SRD5A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18405-S5A1_HUMAN
    Recommended name:
    3-oxo-5-alpha-steroid 4-dehydrogenase 1
    Protein Accession:
    P18405
    Secondary Accessions:
    • B2R7Q1
    • Q9UHY4
    • Q9UP36
    • Q9UP37

    Protein attributes for SRD5A1 Gene

    Size:
    259 amino acids
    Molecular mass:
    29459 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SRD5A1 Gene

Proteomics data for SRD5A1 Gene at MOPED

Post-translational modifications for SRD5A1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SRD5A1 Gene

No data available for DME Specific Peptides for SRD5A1 Gene

Domains & Families for SRD5A1 Gene

Suggested Antigen Peptide Sequences for SRD5A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P18405

UniProtKB/Swiss-Prot:

S5A1_HUMAN :
  • Belongs to the steroid 5-alpha reductase family.
Family:
  • Belongs to the steroid 5-alpha reductase family.
genes like me logo Genes that share domains with SRD5A1: view

No data available for Gene Families for SRD5A1 Gene

Function for SRD5A1 Gene

Molecular function for SRD5A1 Gene

GENATLAS Biochemistry:
steroid 5 alpha-reductase (3-oxo-5 alpha-steroid delta 4-dehydrogenase) alpha polypeptide 1,catalyzing the conversion of testosterone to dihydrotestosterone
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimally active at alkaline pHs.;
UniProtKB/Swiss-Prot CatalyticActivity:
A 3-oxo-5-alpha-steroid + NADP(+) = a 3-oxo-Delta(4)-steroid + NADPH.
UniProtKB/Swiss-Prot Function:
Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
UniProtKB/Swiss-Prot Induction:
Its expression is regulated by androgens such as testosterone.

Enzyme Numbers (IUBMB) for SRD5A1 Gene

genes like me logo Genes that share phenotypes with SRD5A1: view

Animal Models for SRD5A1 Gene

MGI Knock Outs for SRD5A1:

Animal Model Products

miRNA for SRD5A1 Gene

miRTarBase miRNAs that target SRD5A1

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SRD5A1 Gene

Localization for SRD5A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRD5A1 Gene

Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRD5A1 Gene COMPARTMENTS Subcellular localization image for SRD5A1 gene
Compartment Confidence
endoplasmic reticulum 4
extracellular 2
cytosol 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for SRD5A1 Gene

Pathways & Interactions for SRD5A1 Gene

genes like me logo Genes that share pathways with SRD5A1: view

Interacting Proteins for SRD5A1 Gene

Gene Ontology (GO) - Biological Process for SRD5A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001655 urogenital system development IEA --
GO:0006629 lipid metabolic process IEA --
GO:0006694 steroid biosynthetic process IEA --
GO:0006702 androgen biosynthetic process IEA,TAS --
GO:0007530 sex determination NAS 1686016
genes like me logo Genes that share ontologies with SRD5A1: view

No data available for SIGNOR curated interactions for SRD5A1 Gene

Drugs & Compounds for SRD5A1 Gene

(54) Drugs for SRD5A1 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Finasteride Approved Pharma inhibitor, Target Inhibitor of Type II 5α-reductase, Type II 5alpha-reductase inhibitor 66
Dutasteride Approved, Investigational Pharma inhibitor, Target 5-alpha-reductase inhibitor 112
Levonorgestrel Approved, Investigational Pharma Agonist, binder, Target, inhibitor Synthetic progesterone analog 280
Spironolactone Approved Pharma Antagonist, Target, antagonist Mineralocorticoid receptor antagonist 213
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 519

(58) Additional Compounds for SRD5A1 Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
7a,12a-Dihydroxy-5a-cholestan-3-one
  • 7a,12a-Dihydroxy-5a-cholestan-3-one
7a,12a-Dihydroxy-cholestene-3-one
  • 7-a,12-a-Dihydroxy-4-cholesten-3-one
  • 7-a,12-a-Dihydroxycholest-4-en-3-one
  • 7-a,12-alpha-Dihydroxy-4-cholesten-3-one
  • 7-a,12-alpha-Dihydroxycholest-4-en-3-one
  • 7-alpha,12-alpha-Dihydroxy-4-cholesten-3-one
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
Testosterone sulfate
  • 17-O-Sulfotestosterone
  • 17beta-(Sulfooxy)androst-4-en-3-one
  • Testosterone 17-sulfate
  • Testosterone 17-sulphate
  • Testosterone 17b-sulfate
651-45-6

(5) Tocris Compounds for SRD5A1 Gene

Compound Action Cas Number
Auranofin Thioredoxin reductase inhibitor; induces MPT 34031-32-8
Cl-4AS-1 Steroidal androgen receptor agonist 188589-66-4
Finasteride Type II 5alpha-reductase inhibitor 98319-26-7
PX 12 Thioredoxin-1 inhibitor 141400-58-0
TFM-4AS-1 Selective androgen receptor modulator (SARM) 188589-61-9

(2) ApexBio Compounds for SRD5A1 Gene

Compound Action Cas Number
Dutasteride 5-alpha-reductase inhibitor 164656-23-9
Finasteride Inhibitor of Type II 5α-reductase 98319-26-7
genes like me logo Genes that share compounds with SRD5A1: view

Transcripts for SRD5A1 Gene

Unigene Clusters for SRD5A1 Gene

Steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SRD5A1 Gene

No ASD Table

Relevant External Links for SRD5A1 Gene

GeneLoc Exon Structure for
SRD5A1
ECgene alternative splicing isoforms for
SRD5A1

Expression for SRD5A1 Gene

mRNA expression in normal human tissues for SRD5A1 Gene

mRNA differential expression in normal tissues according to GTEx for SRD5A1 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.8) and Liver (x4.7).

Protein differential expression in normal tissues from HIPED for SRD5A1 Gene

This gene is overexpressed in NK cells (65.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SRD5A1 Gene



SOURCE GeneReport for Unigene cluster for SRD5A1 Gene Hs.552

mRNA Expression by UniProt/SwissProt for SRD5A1 Gene

P18405-S5A1_HUMAN
Tissue specificity: Liver and prostate (at a low level).
genes like me logo Genes that share expression patterns with SRD5A1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for SRD5A1 Gene

Orthologs for SRD5A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SRD5A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SRD5A1 35
  • 76.46 (n)
  • 69.44 (a)
SRD5A1 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRD5A1 35
  • 79.1 (n)
  • 73.02 (a)
SRD5A1 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srd5a1 35
  • 72.13 (n)
  • 63.2 (a)
Srd5a1 16
Srd5a1 36
  • 62 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SRD5A1 35
  • 99.61 (n)
  • 100 (a)
SRD5A1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Srd5a1 35
  • 71.66 (n)
  • 62.35 (a)
oppossum
(Monodelphis domestica)
Mammalia SRD5A1 36
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRD5A1 36
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves SRD5A1 35
  • 65.22 (n)
  • 54.15 (a)
SRD5A1 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRD5A1 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia srd5a1 35
  • 57.66 (n)
  • 52.42 (a)
zebrafish
(Danio rerio)
Actinopterygii srd5a1 35
  • 56.59 (n)
  • 53.88 (a)
srd5a1 36
  • 51 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F19H6.4 37
  • 40 (a)
F42F12.3 37
  • 43 (a)
ZK1251.3 37
  • 33 (a)
F19H6.4 36
  • 38 (a)
OneToMany
F42F12.3 36
  • 41 (a)
OneToMany
ZK1251.3 36
  • 31 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons DET2 35
  • 51.25 (n)
  • 45.79 (a)
rice
(Oryza sativa)
Liliopsida Os01g0851600 35
  • 48.23 (n)
  • 39.38 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC9.08c 35
  • 47.6 (n)
  • 39.3 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8786 36
  • 40 (a)
OneToOne
Species with no ortholog for SRD5A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRD5A1 Gene

ENSEMBL:
Gene Tree for SRD5A1 (if available)
TreeFam:
Gene Tree for SRD5A1 (if available)

Paralogs for SRD5A1 Gene

Paralogs for SRD5A1 Gene

(1) SIMAP similar genes for SRD5A1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for SRD5A1 Gene

genes like me logo Genes that share paralogs with SRD5A1: view

Variants for SRD5A1 Gene

Sequence variations from dbSNP and Humsavar for SRD5A1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs3296 -- 6,668,736(+) GAGGC(C/T)GGGGG utr-variant-3-prime
rs3297 -- 6,668,729(-) CCTCT(A/G)TGGCC utr-variant-3-prime
rs13974 -- 6,668,887(+) AGCCC(A/G)GCCCA utr-variant-3-prime
rs824809 -- 6,667,974(-) TTCAC(C/T)TTTCT intron-variant
rs824810 -- 6,666,187(-) CTGGG(C/T)GACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRD5A1 Gene

Variant ID Type Subtype PubMed ID
nsv880892 CNV Loss 21882294
nsv4696 CNV Insertion 18451855
esv275079 CNV Gain+Loss 21479260

Variation tolerance for SRD5A1 Gene

Residual Variation Intolerance Score: 20% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.99; 20.34% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SRD5A1 Gene

Disorders for SRD5A1 Gene

MalaCards: The human disease database

(10) MalaCards diseases for SRD5A1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
prostatic adenoma
  • adenoma - prostate
prostate disease
  • prostatic diseases
polycystic ovary syndrome
  • multicystic ovaries
5-alpha reductase deficiency
  • pseudovaginal perineoscrotal hypospadias
hypospadias
  • familial hypospadias
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SRD5A1

Genetic Association Database (GAD)
SRD5A1
Human Genome Epidemiology (HuGE) Navigator
SRD5A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRD5A1
genes like me logo Genes that share disorders with SRD5A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SRD5A1 Gene

Publications for SRD5A1 Gene

  1. Pharmacologic basis for the enhanced efficacy of dutasteride against prostatic cancers. (PMID: 16818707) Xu Y. … Isaacs J.T. (Clin. Cancer Res. 2006) 3 23 25 26
  2. Characterization and chromosomal mapping of a human steroid 5 alpha- reductase gene and pseudogene and mapping of the mouse homologue. (PMID: 1686016) Jenkins E.P. … Russell D.W. (Genomics 1991) 2 3 4 67
  3. An overview on 5alpha-reductase inhibitors. (PMID: 19879888) Aggarwal S. … Kumar M. (Steroids 2010) 23 25 26
  4. Finasteride in the treatment of patients with benign prostatic hyperplasia: a review. (PMID: 19707263) Smith A.B. … Carson C.C. (Ther Clin Risk Manag 2009) 23 25 26
  5. Inhibition of skin 5 alpha-reductase by oral contraceptive progestins in vitro. (PMID: 11075290) Rabe T. … Rehberger-Schneider S. (Gynecol. Endocrinol. 2000) 23 25 26

Products for SRD5A1 Gene

Sources for SRD5A1 Gene

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