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SRCIN1 Gene

protein-coding   GIFtS: 51
GCID: GC17M036686

SRC Kinase Signaling Inhibitor 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SRC Kinase Signaling Inhibitor 11 2     P1402 3
SNAP-25-Interacting Protein1 2 3     p140Cap2 3
P130Cas-Associated Protein1 2 3     KIAA16843 5
SNIP2 3 5     SNAP25-Interacting Protein2

External Ids:    HGNC: 295061   Entrez Gene: 807252   Ensembl: ENSG000000173737   OMIM: 6107865   UniProtKB: Q9C0H93   

Export aliases for SRCIN1 gene to outside databases

Previous GC identifers: GC17M033943 GC17M032482


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SRCIN1 Gene:
SRCIN1 (SRC kinase signaling inhibitor 1) is a protein-coding gene. Diseases associated with SRCIN1 include paraphimosis, and punctate epithelial keratoconjunctivitis. GO annotations related to this gene include protein kinase binding and protein domain specific binding. An important paralog of this gene is KIAA1217.

UniProtKB/Swiss-Prot: SRCN1_HUMAN, Q9C0H9
Function: Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream
signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in
calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NT_187614.1  NC_018928.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SRCIN1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): SRCIN1 promoter sequence
   Search Chromatin IP Primers for SRCIN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SRCIN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q12

SRCIN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRCIN1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M036686:  view genomic region     (about GC identifiers)

Start:
36,686,251 bp from pter      End:
36,762,183 bp from pter
Size:
75,933 bases      Orientation:
minus strand

1 alternative location:
Chr17-,NW_003315948 313,644-336,476     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SRCN1_HUMAN, Q9C0H9 (See protein sequence)
Recommended Name: SRC kinase signaling inhibitor 1  
Size: 1055 amino acids; 112453 Da
Subunit: Interacts with the N-terminal coiled-coil region of SNAP25 (By similarity). Interacts with BCAR1/p130Cas
and SRC through its C-terminal domain. Interacts with CSK, CTTN, SORBS3/vinexin, SYP and MAPRE3/EB3
Secondary accessions: Q75T46 Q8N4W8
Alternative splicing: 4 isoforms:  Q9C0H9-1   Q9C0H9-2   Q9C0H9-4   Q9C0H9-5   (Ref.1 (BAD03968) sequence is in conflict in position: 177:L->P)

Explore the universe of human proteins at neXtProt for SRCIN1: NX_Q9C0H9

Explore proteomics data for SRCIN1 at MOPED

Post-translational modifications: 

  • Tyrosine-phosphorylated in response to EGF and to cell adhesion to integrin ligands1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SRCIN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079524.2  
    ENSEMBL proteins: 
     ENSP00000264659   ENSP00000462070   ENSP00000445368   ENSP00000462788  

    SRCIN1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for SRCIN1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026727 Srcin1

    Graphical View of Domain Structure for InterPro Entry Q9C0H9

    ProtoNet protein and cluster: Q9C0H9

    UniProtKB/Swiss-Prot: SRCN1_HUMAN, Q9C0H9
    Similarity: Belongs to the SRCIN1 family


    SRCIN1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRCN1_HUMAN, Q9C0H9
    Function: Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream
    signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in
    calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI14657239
    GO:0019901protein kinase binding IDA17525734
    GO:0019904protein domain specific binding IEA--
         
    SRCIN1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SRCIN1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SRCIN1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SRCIN1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SRCIN1

    miRNA
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    Block miRNA regulation of human, mouse, rat SRCIN1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SRCIN1 (see all 120):
    hsa-miR-411* hsa-miR-548j hsa-miR-132* hsa-miR-607 hsa-miR-640 hsa-miR-520e hsa-miR-4272 hsa-miR-106a
    SwitchGear 3'UTR luciferase reporter plasmidSRCIN1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SRCIN1
    Predesigned siRNA for gene silencing in human, mouse, rat SRCIN1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for SRCIN1

    Clone
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    OriGene clones in human, mouse for SRCIN1 (see all 5)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SRCIN1 (NM_025248)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRCIN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRCIN1

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    Browse ESI BIO Cell Lines and PureStem Progenitors for SRCIN1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRCIN1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SRCN1_HUMAN, Q9C0H9: Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, axon (By similarity). Cell projection,
    dendrite (By similarity). Cell junction, synapse (By similarity). Cell junction, synapse, postsynaptic cell
    membrane, postsynaptic density (By similarity). Note=Localized to the perinuclear region, lamellopodia, cortical
    actin and actin stress fibers but not to focal adhesions. Strongly expressed in axons and dendrites of the CA1
    and CA3 hippocampal regions and of the dentate gyrus. Detected in both presynapses and postsynapses and in
    postsynaptic density fractions
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus3
    plasma membrane3
    cytosol2

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA19146815
    GO:0005925NOT focal adhesion IDA14657239
    GO:0014069postsynaptic density ISS--
    GO:0015629actin cytoskeleton IDA14657239
    GO:0030027lamellipodium IEA--

    SRCIN1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SRCIN1 About    
    See pathways by source

    SuperPathContained pathways About
    1Neuroscience
    Neuroscience
    2Cytoskeletal Signaling
    Cytoskeletal Signaling
    3Adhesion
    Adhesion

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Cell Signaling Technology (CST) Pathways for SRCIN1
        Neuroscience
    Cytoskeletal Signaling
    Adhesion



    SRCIN1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SRCIN1
    Interactions:

        Search GeneGlobe Interaction Network for SRCIN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for SRCIN1 (Q9C0H91, 2, 3 ENSP000002646594) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSKP412402, 3, ENSP000002200034MINT-4980194 MINT-4980220 I2D: score=1 STRING: ENSP00000220003
    BCAR1P569451, 3, ENSP000001623304EBI-1393949,EBI-702093 I2D: score=4 STRING: ENSP00000162330
    ACTBP607092, 3, ENSP000003499604MINT-4980243 I2D: score=1 STRING: ENSP00000349960
    SRCP129311, 2, 3, ENSP000003509414EBI-1393949,EBI-621482 MINT-4980194 MINT-5210599 MINT-4980086 MINT-4980101 MINT-4980220 I2D: score=3 STRING: ENSP00000350941
    CRKP461083, ENSP000003005744I2D: score=1 STRING: ENSP00000300574
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006887exocytosis IEA--
    GO:0007162negative regulation of cell adhesion IEA--
    GO:0030334regulation of cell migration IMP17525734
    GO:0034446substrate adhesion-dependent cell spreading IMP17525734
    GO:0050709negative regulation of protein secretion IEA--

    SRCIN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SRCIN1 (SRCN1)

    1 HMDB Compound for SRCIN1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SRCIN1 gene: 
    NM_025248.2  

    Unigene Cluster for SRCIN1:

    SRC kinase signaling inhibitor 1
    Hs.448872  [show with all ESTs]
    Unigene Representative Sequence: NM_025248
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264659(uc002hqd.3) ENST00000578925(uc002hqh.1) ENST00000542707
    ENST00000577193(uc002hqf.1) ENST00000398579(uc002hqe.2) ENST00000584491
    ENST00000581656 ENST00000578160(uc002hqg.3) ENST00000584266
    miRNA
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    Block miRNA regulation of human, mouse, rat SRCIN1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SRCIN1 (see all 120):
    hsa-miR-411* hsa-miR-548j hsa-miR-132* hsa-miR-607 hsa-miR-640 hsa-miR-520e hsa-miR-4272 hsa-miR-106a
    SwitchGear 3'UTR luciferase reporter plasmidSRCIN1 3' UTR sequence
    Inhib. RNA
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SRCIN1 (NM_025248)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRCIN1
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat SRCIN1
      QuantiFast Probe-based Assays in human, mouse, rat SRCIN1

    Additional mRNA sequence: 

    AB051471.1 AB127405.1 AK096097.1 AK126665.1 AK126676.1 AK295027.1 BC019717.1 BC029278.1 
    BC033233.1 BX648057.1 

    8 DOTS entries:

    DT.102943  DT.91646819  DT.101969257  DT.101982112  DT.99935931  DT.75125868  DT.120957368  DT.100677328 

    Selected AceView cDNA sequences (see all 72):

    BC029278 AI275996 AW204846 AB051471 BC033233 AK126665 AK096097 AB127405 
    NM_025248 AK126676 R87915 AW003655 AA324345 R14657 BC019717 AW846954 
    BI912800 BX459918 AI362790 BX281020 BG910822 CB156230 BX119760 BX442635 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SRCIN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SRCIN1 Expression
    About this image


    SRCIN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Eye (Sensory Organs)
             Retina
     
     Brain (Nervous System)
             Cerebral Cortex
    SRCIN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SRCIN1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.448872

    UniProtKB/Swiss-Prot: SRCN1_HUMAN, Q9C0H9
    Tissue specificity: Expressed in some primary breast carcinomas where its presence is significantly associated
    with increased tumor size. Not detected in normal breast tissue

        Custom PCR Arrays for SRCIN1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRCIN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SRCIN1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srcin11 , 5 SRC kinase signaling inhibitor 11, 5 89.03(n)1
    95.6(a)1
      11 (61.00 cM)5
    560131  NM_018873.21  NP_061361.21 
     975093405 
    chicken
    (Gallus gallus)
    Aves SRCIN11 SRC kinase signaling inhibitor 1 76.72(n)
    79.89(a)
      426281  XM_003643769.2  XP_003643817.2 
    lizard
    (Anolis carolinensis)
    Reptilia SRCIN16
    SRC kinase signaling inhibitor 1
    71(a)
    1 ↔ 1
    6(73272088-73699150)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia srcin11 SRC kinase signaling inhibitor 1 69.05(n)
    73.56(a)
      100158628  NM_001128039.1  NP_001121511.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5658631 novel protein similar to vertebrate SNAP25-interacting more 67.63(n)
    68.83(a)
      565863  XM_005164148.1  XP_005164205.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG328096
    --
    20(a)
    1 → many
    X(1567143-1586580)
    worm
    (Caenorhabditis elegans)
    Secernentea Y71H2AM.156
    Protein Y71H2AM.15, isoform b
    19(a)
    1 → many
    III(2747124-2756360) WBGene00022180


    ENSEMBL Gene Tree for SRCIN1 (if available)
    TreeFam Gene Tree for SRCIN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SRCIN1 gene
    KIAA12172  
    1 SIMAP similar gene for SRCIN1 using alignment to 4 protein entries:     SRCN1_HUMAN (see all proteins):
    KIAA1217

    SRCIN1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SRCIN1 (see all 4610)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs27029521,2
    H--34391073(+) aaatcT/Ctgaat 1 -- us2k14Minor allele frequency- C:0.00NS EA 418
    rs26875001,2
    H--34391205(-) gagaaA/Gtcttc 1 -- us2k14Minor allele frequency- G:0.00NS EA 420
    rs20142991,2
    H--34394852(+) gaccaG/Ccctgg 1 -- int14Minor allele frequency- C:0.00NS EA 418
    rs2012533521,2
    C--34493119(+) AGTTTA/GAAGTA 1 -- ut310--------
    rs1998131381,2
    C--34493176(+) GGGCTG/TGGGGT 1 -- ut310--------
    rs2022398971,2
    C--34497300(+) GAATGC/TATCCT 2 T A mis10--------
    rs2016338411,2
    C,F--34499240(+) AAGAAC/TATATG 2 I M mis11Minor allele frequency- T:0.07EU 967
    rs1999128581,2
    C,F--34499247(+) TATGCT/CTCCTT 2 /K /R mis11Minor allele frequency- C:0.12EU 1011
    rs1998787211,2
    F--34499285(+) CGCTGG/CATGTG 2 /I /M mis11Minor allele frequency- C:0.00EU 1061
    rs2018213371,2
    F--34499676(+) TTTCAA/TCTTCA 2 M L mis11Minor allele frequency- T:0.01EU 545

    HapMap Linkage Disequilibrium report for SRCIN1 (36686251 - 36762183 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SRCIN1 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv274624CNV Insertion20981092
    nsv2044CNV Insertion18451855
    nsv2042CNV Insertion18451855
    nsv908194CNV Loss21882294
    nsv908195CNV Loss21882294
    esv1006872CNV Loss20482838
    nsv833438CNV Loss17160897
    nsv833436CNV Loss17160897
    nsv469701CNV Loss16826518
    nsv908193CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610786    OMIM disorders: --

    Selected diseases for SRCIN1 (see all 24):    
    About MalaCards
    paraphimosis    punctate epithelial keratoconjunctivitis    cystoisosporiasis    sclerosing keratitis
    balanoposthitis    loiasis    entropion    elephantiasis
    intestinal volvulus    fascioliasis    onchocerciasis    inverted papilloma
    keratitis    keratoconjunctivitis    papilloma    schistosomiasis
    blindness    cerebritis    tonsillitis    retinitis

    10 diseases from the University of Copenhagen DISEASES database for SRCIN1:
    Onchocerciasis     Sclerosing keratitis     Punctate epithelial keratoconjunctivitis     Schistosomiasis
    Intestinal volvulus     Inverted papilloma     Elephantiasis     Cystoisosporiasis
    Blindness     Fascioliasis

    SRCIN1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SRCIN1

    Export disorders for SRCIN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SRCIN1 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with SRCIN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    2. p130Cas-associated protein (p140Cap) as a new tyrosine-phosphorylated protein involved in cell spreading. (PubMed id 14657239)1, 2, 9 Di Stefano P.... Defilippi P. (Mol. Biol. Cell 2004)
    3. Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity. (PubMed id 19146815)1, 2 Jaworski J.... Hoogenraad C.C. (Neuron 2009)
    4. Characterization of a multidomain adaptor protein, p140Cap, as part of a pre-synaptic complex. (PubMed id 18662323)1, 2 Ito H.... Nagata K. (J. Neurochem. 2008)
    5. SNIP/p140Cap mRNA expression is an unfavourable prognostic factor in breast cancer and is not expressed in normal breast tissue. (PubMed id 18475297)1, 2 Kennedy S....O'Driscoll L. (Br. J. Cancer 2008)
    6. p140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity. (PubMed id 17525734)1, 2 Di Stefano P.... Defilippi P. (EMBO J. 2007)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. SNIP, a novel SNAP-25-interacting protein implicated in regulated exocytosis. (PubMed id 10625663)1, 9 Chin L.S....Li L. (J. Biol. Chem. 2000)
    10. Mapping of p140Cap phosphorylation sites: the EPLYA and EGLYA motifs have a key role in tyrosine phosphorylation and Csk binding, and are substrates of the Abl kinase. (PubMed id 23383002)1 Repetto D....Defilippi P. (PLoS ONE 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80725 HGNC: 29506 AceView: SNIP Ensembl:ENSG00000017373 euGenes: HUgn80725
    ECgene: SRCIN1 H-InvDB: SRCIN1

    (According to HUGE)
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    HUGE: KIAA1684

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SRCIN1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SRCIN1 gene:
    Search GeneIP for patents involving SRCIN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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