Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SRCIN1 Gene

protein-coding   GIFtS: 50
GCID: GC17M036686

SRC kinase signaling inhibitor 1

 Explore 21 diseases affiliated with
SRCIN1 via our new
 Human Malady Compendium 
Biological research products
for SRCIN1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
SRC Kinase Signaling Inhibitor 11 2     P130Cas-Associated Protein2 3
SNIP1 2 3 5     P1402 3
P140Cap1     SNAP-25-Interacting Protein2 3
KIAA16841 3 5     SNAP25-Interacting Protein2

External Ids:    HGNC: 295061   Entrez Gene: 807252   Ensembl: ENSG000000173737   OMIM: 6107865   UniProtKB: Q9C0H93   

Export aliases for SRCIN1 gene to outside databases

Previous GC identifers: GC17M033943 GC17M032482


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SRCN1_HUMAN, Q9C0H9
Function: Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling,
leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent
exocytosis. May play a role in neurotransmitter release or synapse maintenance




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SRCIN1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): SRCIN1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SRCIN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRCIN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q12

SRCIN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRCIN1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M036686:  view genomic region     (about GC identifiers)

Start:
36,686,251 bp from pter      End:
36,762,183 bp from pter
Size:
75,933 bases      Orientation:
minus strand

1 alternative location:
Chr17-,PATCHES 36,686,259-36,709,091     

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SRCN1_HUMAN, Q9C0H9 (See protein sequence)
Recommended Name: SRC kinase signaling inhibitor 1  
Size: 1055 amino acids; 112453 Da
Subunit: Interacts with the N-terminal coiled-coil region of SNAP25 (By similarity). Interacts with BCAR1/p130Cas and
SRC through its C-terminal domain. Interacts with CSK, CTTN, SORBS3/vinexin, SYP and MAPRE3/EB3
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, axon (By similarity). Cell projection,
dendrite (By similarity). Cell junction, synapse (By similarity). Cell junction, synapse, postsynaptic cell membrane,
postsynaptic density (By similarity). Note=Localized to the perinuclear region, lamellopodia, cortical actin and actin
stress fibers but not to focal adhesions. Strongly expressed in axons and dendrites of the CA1 and CA3 hippocampal
regions and of the dentate gyrus. Detected in both presynapses and postsynapses and in postsynaptic density fractions
Secondary accessions: Q75T46 Q8N4W8
Alternative splicing: 4 isoforms:  Q9C0H9-1   Q9C0H9-2   Q9C0H9-4   Q9C0H9-5   (Ref.1 (BAD03968) sequence is in conflict in position: 177:L->P)

Explore the universe of human proteins at neXtProt for SRCIN1: NX_Q9C0H9

Post-translational modifications:

  • Tyrosine-phosphorylated in response to EGF and to cell adhesion to integrin ligands1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9C0H9

  • SRCIN1 Protein expression data from MOPED and PaxDb:    About this image 
    SRCIN1 Protein Expression
    REFSEQ proteins: NP_079524.2  
    ENSEMBL proteins: 
     ENSP00000264659   ENSP00000462070   ENSP00000445368   ENSP00000462788  

    Human Recombinant Protein Products for SRCIN1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for SRCIN1 
    GenScript Custom Purified and Recombinant Proteins Services for SRCIN1
    Novus Biologicals SRCIN1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SRCIN1

    Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA19146815
    GO:0005886plasma membrane IEA--
    GO:0005925NOT focal adhesion IDA14657239
    GO:0014069postsynaptic density ISS--
    GO:0015629actin cytoskeleton IDA14657239

    SRCIN1 for ontologies           About GeneDecksing



    SRCIN1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for SRCIN1  (SNIP)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SRCIN1 
    GenScript Custom Superior Antibodies Services for SRCIN1
    Novus Biologicals SRCIN1 Antibodies
    Abcam antibodies for SRCIN1 
    Uscn Antibodies for SRCIN1
    ThermoFisher Antibodies for SRCIN1

    Assay Products for SRCIN1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SRCIN1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SRCIN1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SRCIN1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR026727 Srcin1

    Graphical View of Domain Structure for InterPro Entry Q9C0H9

    ProtoNet protein and cluster: Q9C0H9

    UniProtKB/Swiss-Prot: SRCN1_HUMAN, Q9C0H9
    Similarity: Belongs to the SRCIN1 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRCN1_HUMAN, Q9C0H9
    Function: Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling,
    leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent
    exocytosis. May play a role in neurotransmitter release or synapse maintenance

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17525734
    GO:0019901protein kinase binding IDA17525734
    GO:0019904protein domain specific binding IEA--
         
    SRCIN1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SRCIN1 

    miRNA
    Products:
        
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SRCIN1
    8/120 QIAGEN miScript miRNA Assays for microRNAs that regulate SRCIN1 (see all 120):
    hsa-miR-411* hsa-miR-548j hsa-miR-132* hsa-miR-607 hsa-miR-640 hsa-miR-520e hsa-miR-4272 hsa-miR-106a
    SwitchGear 3'UTR luciferase reporter plasmidSRCIN1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SRCIN1 (see all 6)
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRCIN1
    Sirion Biotech Custom design and validation of potent shRNA sequences against SRCIN1 

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SRCIN1
    Sirion Biotech Customized adenovirus for overexpression of SRCIN1 
    Sirion Biotech Customized adenovirus for potent knockdown of SRCIN1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRCIN1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRCIN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SRCIN1 (NM_025248)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRCIN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRCIN1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SRCIN1
    Search LifeMap BioReagents cell lines for SRCIN1
    Sirion Biotech Customized stable knockdown cell line services for SRCIN1 
    Sirion Biotech Customized inducible knockdown cell line services for SRCIN1
    Sirion Biotech Customized stable overexpressing cell line services for SRCIN1
    Sirion Biotech Customized inducible overexpressing cell line services for SRCIN1

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRCIN1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cytoskeletal Signaling
    Cytoskeletal Signaling1.00
    2Adhesion
    Adhesion1.00
    3Neuroscience
    Neuroscience1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3 Cell Signaling Technology (CST) Pathways for SRCIN1
        Neuroscience
    Cytoskeletal Signaling
    Adhesion



    SRCIN1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SRCIN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/18 Interacting proteins for SRCIN1 (Q9C0H91, 2, 3 ENSP000002646594) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSKP412402, 3, ENSP000002200034MINT-4980194 MINT-4980220 I2D: score=1 STRING: ENSP00000220003
    BCAR1P569451, 3, ENSP000001623304EBI-1393949,EBI-702093 I2D: score=4 STRING: ENSP00000162330
    ACTBP607092, 3, ENSP000003499604MINT-4980243 I2D: score=1 STRING: ENSP00000349960
    SRCP129311, 2, 3, ENSP000003509414EBI-1393949,EBI-1383910 MINT-4980194 MINT-5210599 MINT-4980086 MINT-4980101 MINT-4980220 I2D: score=3 STRING: ENSP00000350941
    CRKP461083, ENSP000003005744I2D: score=1 STRING: ENSP00000300574
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006887exocytosis IEA--
    GO:0007162negative regulation of cell adhesion IEA--
    GO:0030334regulation of cell migration IMP17525734
    GO:0034446substrate adhesion-dependent cell spreading IMP17525734
    GO:0050709negative regulation of protein secretion IEA--

    SRCIN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SRCIN1

    1 HMDB Compound for SRCIN1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Search CenterWatch for drugs/clinical trials and news about SRCIN1 / SRCN1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SRCIN1 gene: 
    NM_025248.2  

    Unigene Cluster for SRCIN1:

    SRC kinase signaling inhibitor 1
    Hs.448872  [show with all ESTs]
    Unigene Representative Sequence: NM_025248
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264659(uc002hqd.3) ENST00000578925(uc002hqh.1) ENST00000542707
    ENST00000577193(uc002hqf.1) ENST00000398579(uc002hqe.2) ENST00000584491
    ENST00000581656 ENST00000578160(uc002hqg.3) ENST00000584266

    miRNA
    Products:
         
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SRCIN1
    8/120 QIAGEN miScript miRNA Assays for microRNAs that regulate SRCIN1 (see all 120):
    hsa-miR-411* hsa-miR-548j hsa-miR-132* hsa-miR-607 hsa-miR-640 hsa-miR-520e hsa-miR-4272 hsa-miR-106a
    SwitchGear 3'UTR luciferase reporter plasmidSRCIN1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SRCIN1 (see all 6)
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRCIN1
    Sirion Biotech Custom design and validation of potent shRNA sequences against SRCIN1 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRCIN1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRCIN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SRCIN1 (NM_025248)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRCIN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRCIN1 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SRCIN1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SRCIN1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRCIN1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRCIN1

    Additional cDNA sequence: 

    AB051471.1 AB127405.1 AK096097.1 AK126665.1 AK126676.1 AK295027.1 BC019717.1 BC029278.1 
    BC033233.1 BX648057.1 

    8 DOTS entries:

    DT.102943  DT.91646819  DT.101969257  DT.101982112  DT.99935931  DT.75125868  DT.120957368  DT.100677328 

    24/72 AceView cDNA sequences (see all 72):

    R14657 AK096097 AK126665 BI912800 AI275996 AW003655 AA324345 BC019717 
    AW204846 AB051471 BC029278 BC033233 AW846954 R87915 AK126676 NM_025248 
    AB127405 CB156230 BG910822 BF062187 BX459918 BM701294 AI362790 BX648057 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SRCIN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    SRCIN1 Expression
    About this image
    See SRCIN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SRCIN1

    SOURCE GeneReport for Unigene cluster: Hs.448872

    UniProtKB/Swiss-Prot: SRCN1_HUMAN, Q9C0H9
    Tissue specificity: Expressed in some primary breast carcinomas where its presence is significantly associated with
    increased tumor size. Not detected in normal breast tissue

        SABiosciences Custom PCR Arrays for SRCIN1
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SRCIN1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SRCIN1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRCIN1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRCIN1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRCIN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SRCIN1 gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SRCIN11 SRC kinase signaling inhibitor 1 77.1(n)
    80.42(a)
      426281  XM_003643769.1  XP_003643817.1 
    lizard
    (Anolis carolinensis)
    Reptilia SRCIN16
    --
    74(a)
    1 ↔ 1
    6(73633789-73699150)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5658631 novel protein similar to vertebrate SNAP25-interacting more 65.81(n)
    66.7(a)
      565863  XM_689126.4  XP_694218.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG328096
    --
    17(a)
    1 → many
    X(1567143-1586580)
    worm
    (Caenorhabditis elegans)
    Secernentea Y71H2AM.156
    Protein Y71H2AM.15, isoform b
    20(a)
    1 → many
    III(2747116-2756352)


    ENSEMBL Gene Tree for SRCIN1 (if available)
    TreeFam Gene Tree for SRCIN1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SRCIN1 gene
    KIAA12172  
    1 SIMAP similar gene for SRCIN1 using alignment to 4 protein entries:     SRCN1_HUMAN (see all proteins):
    KIAA1217

    SRCIN1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1114 NCBI SNPs in SRCIN1 are shown (see all 1114    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1156243881,2
    F--36685803(+) ACTCTG/TGGTAA 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1892925651,2
    --36685840(+) ACTTGC/TCTGAG 1 -- ds50010--------
    rs1463342381,2
    --36685856(+) AGTGCC/TGGTAG 1 -- ds50010--------
    rs1811684921,2
    --36685872(+) TCACCA/GATGGT 1 -- ds50010--------
    rs2002257481,2
    --36685924(+) GAACT-/GGTTTT 1 -- ds50010--------
    rs2012678951,2
    --36685924(+) AACTG-/TGTTTT 1 -- ds50010--------
    rs39900461,2
    C,F,H--36685925(-) aaaaaC/ACAGTT 1 -- ds50018Minor allele frequency- A:0.06NS EA NA 556
    rs1167819601,2
    F--36686077(+) TACTGG/ATGTAC 1 -- ds50011Minor allele frequency- A:0.04WA 118
    rs1382828561,2
    --36686091(+) ACCCCA/GCCTGG 1 -- ds50010--------
    rs1148207131,2
    --36686126(+) CCTCCC/TCCTCA 1 -- ds50011Minor allele frequency- T:0.01WA 118

    HapMap Linkage Disequilibrium report for SRCIN1 (36686251 - 36762183 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for SRCIN1
         4 CNVs: 67187 4034 30828 2224

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SRCIN1
    DNA2.0 Custom Variant and Variant Library Synthesis for SRCIN1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SRCIN1 for disorders           About GeneDecksing

    OMIM gene information: 610786    OMIM disorders: --

    20/21 diseases for SRCIN1 (see all 21):    About MalaCards
    punctate epithelial keratoconjunctivitis    intestinal volvulus    paraphimosis    inverted papilloma
    cystoisosporiasis    balanoposthitis    loiasis    sclerosing keratitis
    entropion    elephantiasis    keratoconjunctivitis    keratitis
    onchocerciasis    fascioliasis    schistosomiasis    papilloma
    blindness    breast carcinoma    breast cancer    cerebritis

    11 diseases from the University of Copenhagen DISEASES database for SRCIN1:
    Onchocerciasis     Sclerosing keratitis     Punctate epithelial keratoconjunctivitis     Schistosomiasis
    Intestinal volvulus     Inverted papilloma     Elephantiasis     Loiasis
    Cystoisosporiasis     Fascioliasis     Blindness

    Export disorders for SRCIN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SRCIN1 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with SRCIN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (2000)
    2. p130Cas-associated protein (p140Cap) as a new tyrosine-phosphorylated protein involved in cell spreading. (PubMed id 14657239)1, 2, 9 Di Stefano P.... Defilippi P. (2004)
    3. Dynamic microtubules regulate dendritic spine morphol ogy and synaptic plasticity. (PubMed id 19146815)1, 2 Jaworski J....Hoogenraad C.C. (2009)
    4. SNIP/p140Cap mRNA expression is an unfavourable prognostic factor in breast cancer and is not expressed in normal breast tissue. (PubMed id 18475297)1, 2 Kennedy S....O'Driscoll L. (2008)
    5. p140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity. (PubMed id 17525734)1, 2 Di Stefano P....Defilippi P. (2007)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. SNIP, a novel SNAP-25-interacting protein implicated in regulated exocytosis. (PubMed id 10625663)1, 9 Chin L.S....Li L. (2000)
    9. p140Cap dual regulation of E-cadherin/EGFR cross-talk and Ras signalling in tumour cell scatter and proliferation. (PubMed id 20453886)1 Damiano L....Defilippi P. (2010)
    10. Characterization of a multidomain adaptor protein, p1 40Cap, as part of a pre-synaptic complex. (PubMed id 18662323)2 Ito H....Nagata K. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80725 HGNC: 29506 AceView: SNIP Ensembl:ENSG00000017373 euGenes: HUgn80725
    ECgene: SRCIN1 H-InvDB: SRCIN1

    (According to HUGE)
    About This Section
    HUGE: KIAA1684

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SRCIN1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SRCIN1 gene:
    Search GeneIP for patents involving SRCIN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   Browse OriGene shRNA RFPs  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SRCIN1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SRCIN1  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     Browse OriGene siRNAs   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRCIN1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRCIN1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SRCIN1   OriGene Custom Protein Services for SRCIN1  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SRCIN1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SRCIN1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRCIN1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRCIN1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRCIN1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRCIN1
     GenScript Custom Purified and Recombinant Proteins Services for SRCIN1 GenScript cDNA clones with any tag delivered in your preferred vector for SRCIN1
     GenScript Custom Assay Services for SRCIN1 GenScript Custom Superior Antibodies Services for SRCIN1
     GenScript Custom overexpressing Cell Line Services for SRCIN1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for SRCIN1  (SNIP)

     Search Regulatory tfbs for SRCIN1
     Search Chromatin IP Primers for SRCIN1
     RT2 qPCR Primer Assay in human, mouse, rat SRCIN1
     Search GNC Networks for SRCIN1
     SABiosciences Custom PCR Arrays for SRCIN1
     Search Tocris compounds for SRCIN1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SRCIN1 antibodies
     SRCIN1 proteins
     Antibodies for SRCIN1
     See all of Abcam's Antibodies, Kits and Proteins for SRCIN1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     SRCIN1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for SRCIN1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRCIN1
     SwitchGear 3'UTR luciferase reporter plasmids for SRCIN1
     SwitchGear Promoter luciferase reporter plasmids for SRCIN1
     ThermoFisher Antibodies for SRCIN1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRCIN1
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SRCIN1
    Sirion Biotech Customized:
     stable knockdown cell line services for SRCIN1
     inducible knockdown cell line services for SRCIN1
     design and validation of potent shRNA sequences against SRCIN1
     adenovirus for potent knockdown of SRCIN1
     adenovirus for overexpression of SRCIN1
     stable overexpressing cell line services for SRCIN1
     inducible overexpressing cell line services for SRCIN1
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SRCIN1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4