Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SRCIN1 Gene

Aliases for SRCIN1 Gene

  • SRC Kinase Signaling Inhibitor 1 2 3 5
  • SNAP-25-Interacting Protein 2 3 4
  • P130Cas-Associated Protein 2 3 4
  • P140Cap 3 4
  • P140 3 4
  • SNIP 3 4
  • SNAP25-Interacting Protein 3
  • KIAA1684 4

External Ids for SRCIN1 Gene

Previous GeneCards Identifiers for SRCIN1 Gene

  • GC17M033943
  • GC17M036686
  • GC17M032482

Summaries for SRCIN1 Gene

GeneCards Summary for SRCIN1 Gene

SRCIN1 (SRC Kinase Signaling Inhibitor 1) is a Protein Coding gene. Diseases associated with SRCIN1 include sclerosing keratitis and loiasis. GO annotations related to this gene include protein kinase binding and protein domain specific binding. An important paralog of this gene is KIAA1217.

UniProtKB/Swiss-Prot for SRCIN1 Gene

  • Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRCIN1 Gene

Genomics for SRCIN1 Gene

Regulatory Elements for SRCIN1 Gene

Promoters for SRCIN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SRCIN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SRCIN1 Gene

Chromosome:
17
Start:
38,530,016 bp from pter
End:
38,605,930 bp from pter
Size:
75,915 bases
Orientation:
Minus strand

Genomic View for SRCIN1 Gene

Genes around SRCIN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRCIN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRCIN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRCIN1 Gene

Proteins for SRCIN1 Gene

  • Protein details for SRCIN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0H9-SRCN1_HUMAN
    Recommended name:
    SRC kinase signaling inhibitor 1
    Protein Accession:
    Q9C0H9
    Secondary Accessions:
    • Q75T46
    • Q8N4W8

    Protein attributes for SRCIN1 Gene

    Size:
    1055 amino acids
    Molecular mass:
    112453 Da
    Quaternary structure:
    • Interacts with the N-terminal coiled-coil region of SNAP25 (By similarity). Interacts with BCAR1/p130Cas and SRC through its C-terminal domain. Interacts with CSK, CTTN, SORBS3/vinexin, SYP and MAPRE3/EB3.

    Alternative splice isoforms for SRCIN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRCIN1 Gene

Proteomics data for SRCIN1 Gene at MOPED

Post-translational modifications for SRCIN1 Gene

  • Tyrosine-phosphorylated in response to EGF and to cell adhesion to integrin ligands.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SRCIN1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SRCIN1 (SNIP)

No data available for DME Specific Peptides for SRCIN1 Gene

Domains & Families for SRCIN1 Gene

Protein Domains for SRCIN1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SRCIN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9C0H9

UniProtKB/Swiss-Prot:

SRCN1_HUMAN :
  • Belongs to the SRCIN1 family.
Family:
  • Belongs to the SRCIN1 family.
genes like me logo Genes that share domains with SRCIN1: view

No data available for Gene Families for SRCIN1 Gene

Function for SRCIN1 Gene

Molecular function for SRCIN1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance.

Phenotypes for SRCIN1 Gene

genes like me logo Genes that share phenotypes with SRCIN1: view

Animal Models for SRCIN1 Gene

MGI Knock Outs for SRCIN1:

Animal Model Products

miRNA for SRCIN1 Gene

miRTarBase miRNAs that target SRCIN1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SRCIN1 Gene

Localization for SRCIN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRCIN1 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, axon. Cell projection, dendrite. Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Localized to the perinuclear region, lamellopodia, cortical actin and actin stress fibers but not to focal adhesions. Strongly expressed in axons and dendrites of the CA1 and CA3 hippocampal regions and of the dentate gyrus. Detected in both presynapses and postsynapses and in postsynaptic density fractions.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRCIN1 Gene COMPARTMENTS Subcellular localization image for SRCIN1 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SRCIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005925 NOT focal adhesion IDA 14657239
GO:0014069 postsynaptic density IEA,ISS --
GO:0030027 lamellipodium IEA --
GO:0030425 dendrite IEA,ISS --
GO:0043005 neuron projection IEA --
genes like me logo Genes that share ontologies with SRCIN1: view

Pathways & Interactions for SRCIN1 Gene

SuperPathways for SRCIN1 Gene

No Data Available

SIGNOR curated interactions for SRCIN1 Gene

Other effect:

Gene Ontology (GO) - Biological Process for SRCIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0061098 positive regulation of protein tyrosine kinase activity IDA 17525734
genes like me logo Genes that share ontologies with SRCIN1: view

No data available for Pathways by source for SRCIN1 Gene

Drugs & Compounds for SRCIN1 Gene

(1) Drugs for SRCIN1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with SRCIN1: view

Transcripts for SRCIN1 Gene

Unigene Clusters for SRCIN1 Gene

SRC kinase signaling inhibitor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SRCIN1 Gene

No ASD Table

Relevant External Links for SRCIN1 Gene

GeneLoc Exon Structure for
SRCIN1
ECgene alternative splicing isoforms for
SRCIN1

Expression for SRCIN1 Gene

mRNA expression in normal human tissues for SRCIN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SRCIN1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.2), Brain - Cerebellar Hemisphere (x5.6), Brain - Cerebellum (x5.5), and Brain - Substantia nigra (x4.4).

Protein differential expression in normal tissues from HIPED for SRCIN1 Gene

This gene is overexpressed in Frontal cortex (25.5), Brain (23.6), and Fetal Brain (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for SRCIN1 Gene



SOURCE GeneReport for Unigene cluster for SRCIN1 Gene Hs.448872

mRNA Expression by UniProt/SwissProt for SRCIN1 Gene

Q9C0H9-SRCN1_HUMAN
Tissue specificity: Expressed in some primary breast carcinomas where its presence is significantly associated with increased tumor size. Not detected in normal breast tissue.
genes like me logo Genes that share expression patterns with SRCIN1: view

Protein tissue co-expression partners for SRCIN1 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for SRCIN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SRCIN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRCIN1 35
  • 99.01 (n)
  • 98.91 (a)
cow
(Bos Taurus)
Mammalia SRCIN1 35
  • 92.41 (n)
  • 96.93 (a)
dog
(Canis familiaris)
Mammalia SRCIN1 35
  • 91.82 (n)
  • 95.83 (a)
mouse
(Mus musculus)
Mammalia Srcin1 35
  • 89.03 (n)
  • 95.6 (a)
Srcin1 16
rat
(Rattus norvegicus)
Mammalia Srcin1 35
  • 88.48 (n)
  • 95.58 (a)
chicken
(Gallus gallus)
Aves SRCIN1 35
  • 76.72 (n)
  • 79.89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia srcin1 35
  • 69.05 (n)
  • 73.56 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC565863 35
  • 67.63 (n)
  • 68.83 (a)
Species with no ortholog for SRCIN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SRCIN1 Gene

ENSEMBL:
Gene Tree for SRCIN1 (if available)
TreeFam:
Gene Tree for SRCIN1 (if available)

Paralogs for SRCIN1 Gene

Paralogs for SRCIN1 Gene

(1) SIMAP similar genes for SRCIN1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SRCIN1: view

Variants for SRCIN1 Gene

Sequence variations from dbSNP and Humsavar for SRCIN1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2471628 -- 38,588,420(+) GCTCC(A/G)CTGCT intron-variant
rs2471629 -- 38,589,668(+) GCTCA(A/G)CGCCT intron-variant
rs2471630 -- 38,589,824(+) CCGAA(C/T)CTGCA intron-variant
rs2471631 -- 38,590,667(+) ACTGA(A/G)GCTCA intron-variant
rs2471632 -- 38,595,287(+) ATCTC(A/G)GCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRCIN1 Gene

Variant ID Type Subtype PubMed ID
dgv957e1 CNV Complex 17122850
nsv469701 CNV Loss 16826518
dgv959e1 CNV Complex 17122850
nsv908193 CNV Loss 21882294
nsv833436 CNV Loss 17160897
esv27695 CNV Gain 19812545
nsv9549 CNV Gain 18304495
nsv908194 CNV Loss 21882294
nsv2042 CNV Insertion 18451855
nsv908195 CNV Loss 21882294
nsv827980 CNV Gain 20364138
esv1006872 CNV Loss 20482838
nsv2044 CNV Insertion 18451855
nsv833438 CNV Loss 17160897
esv274624 CNV Insertion 20981092
nsv827981 CNV Gain 20364138

Variation tolerance for SRCIN1 Gene

Residual Variation Intolerance Score: 51.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.09; 60.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRCIN1 Gene

HapMap Linkage Disequilibrium report
SRCIN1
Human Gene Mutation Database (HGMD)
SRCIN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRCIN1 Gene

Disorders for SRCIN1 Gene

MalaCards: The human disease database

(21) MalaCards diseases for SRCIN1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
sclerosing keratitis
  • sclerokeratitis
loiasis
  • african eye worm
punctate epithelial keratoconjunctivitis
  • punctate keratitis
anterior scleritis
deep keratitis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SRCIN1

Genetic Association Database (GAD)
SRCIN1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRCIN1
genes like me logo Genes that share disorders with SRCIN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SRCIN1 Gene

Publications for SRCIN1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. p130Cas-associated protein (p140Cap) as a new tyrosine-phosphorylated protein involved in cell spreading. (PMID: 14657239) Di Stefano P. … Defilippi P. (Mol. Biol. Cell 2004) 3 23
  3. SNIP, a novel SNAP-25-interacting protein implicated in regulated exocytosis. (PMID: 10625663) Chin L.S. … Li L. (J. Biol. Chem. 2000) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for SRCIN1 Gene

Sources for SRCIN1 Gene

Back to Top

Content