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Aliases for SRCIN1 Gene

Aliases for SRCIN1 Gene

  • SRC Kinase Signaling Inhibitor 1 2 3
  • SNAP-25-Interacting Protein 2 3 4
  • P130Cas-Associated Protein 2 3 4
  • SNIP 3 4 6
  • KIAA1684 4 6
  • P140Cap 3 4
  • P140 3 4
  • SNAP25-Interacting Protein 3

External Ids for SRCIN1 Gene

Previous GeneCards Identifiers for SRCIN1 Gene

  • GC17M033943
  • GC17M036686
  • GC17M032482

Summaries for SRCIN1 Gene

GeneCards Summary for SRCIN1 Gene

SRCIN1 (SRC Kinase Signaling Inhibitor 1) is a Protein Coding gene. Diseases associated with SRCIN1 include punctate epithelial keratoconjunctivitis and cystoisosporiasis. Among its related pathways are Cytoskeletal Signaling and Adhesion. GO annotations related to this gene include protein kinase binding and protein domain specific binding.

UniProtKB/Swiss-Prot for SRCIN1 Gene

  • Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRCIN1 Gene

Genomics for SRCIN1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SRCIN1 Gene

Start:
38,530,016 bp from pter
End:
38,605,930 bp from pter
Size:
75,915 bases
Orientation:
Minus strand

Genomic View for SRCIN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SRCIN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRCIN1 Gene

No data available for Regulatory Elements for SRCIN1 Gene

Proteins for SRCIN1 Gene

  • Protein details for SRCIN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0H9-SRCN1_HUMAN
    Recommended name:
    SRC kinase signaling inhibitor 1
    Protein Accession:
    Q9C0H9
    Secondary Accessions:
    • Q75T46
    • Q8N4W8

    Protein attributes for SRCIN1 Gene

    Size:
    1055 amino acids
    Molecular mass:
    112453 Da
    Quaternary structure:
    • Interacts with the N-terminal coiled-coil region of SNAP25 (By similarity). Interacts with BCAR1/p130Cas and SRC through its C-terminal domain. Interacts with CSK, CTTN, SORBS3/vinexin, SYP and MAPRE3/EB3.

    Alternative splice isoforms for SRCIN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRCIN1 Gene

Proteomics data for SRCIN1 Gene at MOPED

Post-translational modifications for SRCIN1 Gene

  • Tyrosine-phosphorylated in response to EGF and to cell adhesion to integrin ligands.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SRCIN1 Gene

No data available for DME Specific Peptides for SRCIN1 Gene

Domains for SRCIN1 Gene

Protein Domains for SRCIN1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SRCIN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9C0H9

UniProtKB/Swiss-Prot:

SRCN1_HUMAN :
  • Q9C0H9
Family:
  • Belongs to the SRCIN1 family.
genes like me logo Genes that share domains with SRCIN1: view

No data available for Gene Families for SRCIN1 Gene

Function for SRCIN1 Gene

Molecular function for SRCIN1 Gene

UniProtKB/Swiss-Prot Function: Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance.

Gene Ontology (GO) - Molecular Function for SRCIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14657239
GO:0019901 protein kinase binding IDA 17525734
GO:0019904 protein domain specific binding --
genes like me logo Genes that share ontologies with SRCIN1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SRCIN1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SRCIN1 Gene

Localization for SRCIN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRCIN1 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, axon. Cell projection, dendrite. Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Localized to the perinuclear region, lamellopodia, cortical actin and actin stress fibers but not to focal adhesions. Strongly expressed in axons and dendrites of the CA1 and CA3 hippocampal regions and of the dentate gyrus. Detected in both presynapses and postsynapses and in postsynaptic density fractions.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRCIN1 Gene COMPARTMENTS Subcellular localization image for SRCIN1 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
plasma membrane 3
cytosol 2

Gene Ontology (GO) - Cellular Components for SRCIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 19146815
GO:0005925 NOT focal adhesion IDA 14657239
GO:0014069 postsynaptic density ISS --
GO:0015629 actin cytoskeleton IDA 14657239
GO:0030027 lamellipodium --
genes like me logo Genes that share ontologies with SRCIN1: view

Pathways for SRCIN1 Gene

genes like me logo Genes that share pathways with SRCIN1: view

Pathways by source for SRCIN1 Gene

3 Cell Signaling Technology pathways for SRCIN1 Gene

Gene Ontology (GO) - Biological Process for SRCIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis IEA --
GO:0007162 negative regulation of cell adhesion --
GO:0030334 regulation of cell migration IMP 17525734
GO:0034446 substrate adhesion-dependent cell spreading IMP 17525734
GO:0050709 negative regulation of protein secretion --
genes like me logo Genes that share ontologies with SRCIN1: view

Compounds for SRCIN1 Gene

(1) HMDB Compounds for SRCIN1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with SRCIN1: view

Transcripts for SRCIN1 Gene

mRNA/cDNA for SRCIN1 Gene

Unigene Clusters for SRCIN1 Gene

SRC kinase signaling inhibitor 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SRCIN1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SRCIN1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRCIN1 Gene

No ASD Table

Relevant External Links for SRCIN1 Gene

GeneLoc Exon Structure for
SRCIN1
ECgene alternative splicing isoforms for
SRCIN1

Expression for SRCIN1 Gene

mRNA expression in normal human tissues for SRCIN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SRCIN1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (6.2), Brain - Cerebellar Hemisphere (5.6), Brain - Cerebellum (5.5), and Brain - Substantia nigra (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SRCIN1 Gene

SOURCE GeneReport for Unigene cluster for SRCIN1 Gene Hs.448872

mRNA Expression by UniProt/SwissProt for SRCIN1 Gene

Q9C0H9-SRCN1_HUMAN
Tissue specificity: Expressed in some primary breast carcinomas where its presence is significantly associated with increased tumor size. Not detected in normal breast tissue.
genes like me logo Genes that share expressions with SRCIN1: view

In Situ Assay Products

Orthologs for SRCIN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SRCIN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRCIN1 35
  • 99.01 (n)
  • 98.91 (a)
cow
(Bos Taurus)
Mammalia SRCIN1 35
  • 92.41 (n)
  • 96.93 (a)
dog
(Canis familiaris)
Mammalia SRCIN1 35
  • 91.82 (n)
  • 95.83 (a)
mouse
(Mus musculus)
Mammalia Srcin1 35
  • 89.03 (n)
  • 95.6 (a)
Srcin1 16
rat
(Rattus norvegicus)
Mammalia Srcin1 35
  • 88.48 (n)
  • 95.58 (a)
chicken
(Gallus gallus)
Aves SRCIN1 35
  • 76.72 (n)
  • 79.89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia srcin1 35
  • 69.05 (n)
  • 73.56 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC565863 35
  • 67.63 (n)
  • 68.83 (a)
Species with no ortholog for SRCIN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SRCIN1 Gene

ENSEMBL:
Gene Tree for SRCIN1 (if available)
TreeFam:
Gene Tree for SRCIN1 (if available)

Paralogs for SRCIN1 Gene

Selected SIMAP similar genes for SRCIN1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SRCIN1: view

No data available for Paralogs for SRCIN1 Gene

Variants for SRCIN1 Gene

Sequence variations from dbSNP and Humsavar for SRCIN1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1912410 -- 38,531,055(-) CCACG(G/T)GCCCC utr-variant-3-prime
rs1912411 -- 38,531,050(-) TGCCC(C/T)GCCCC utr-variant-3-prime
rs2036799 -- 38,538,434(-) TTATT(A/T)TTTTT intron-variant
rs2075051 -- 38,557,767(+) CTGGA(C/T)TCAGA intron-variant
rs2075063 -- 38,589,206(+) CCACC(A/G)TGCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRCIN1 Gene

Variant ID Type Subtype PubMed ID
dgv957e1 CNV Complex 17122850
nsv469701 CNV Loss 16826518
dgv959e1 CNV Complex 17122850
nsv908193 CNV Loss 21882294
nsv833436 CNV Loss 17160897
esv27695 CNV Gain 19812545
nsv9549 CNV Gain 18304495
nsv908194 CNV Loss 21882294
nsv2042 CNV Insertion 18451855
nsv908195 CNV Loss 21882294
nsv827980 CNV Gain 20364138
esv1006872 CNV Loss 20482838
nsv2044 CNV Insertion 18451855
nsv833438 CNV Loss 17160897
esv274624 CNV Insertion 20981092
nsv827981 CNV Gain 20364138

Relevant External Links for SRCIN1 Gene

HapMap Linkage Disequilibrium report
SRCIN1
Human Gene Mutation Database (HGMD)
SRCIN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRCIN1 Gene

Disorders for SRCIN1 Gene

Relevant External Links for SRCIN1

Genetic Association Database (GAD)
SRCIN1
genes like me logo Genes that share disorders with SRCIN1: view

No data available for UniProtKB/Swiss-Prot for SRCIN1 Gene

Publications for SRCIN1 Gene

  1. p130Cas-associated protein (p140Cap) as a new tyrosine-phosphorylated protein involved in cell spreading. (PMID: 14657239) Di Stefano P. … Defilippi P. (Mol. Biol. Cell 2004) 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. SNIP, a novel SNAP-25-interacting protein implicated in regulated exocytosis. (PMID: 10625663) Chin L.S. … Li L. (J. Biol. Chem. 2000) 3 23

Products for SRCIN1 Gene

Sources for SRCIN1 Gene

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