Aliases for SRCAP Gene
Aliases for SRCAP Gene
- Snf2 Related CREBBP Activator Protein 2 3 5
- Domino Homolog 2 3 4
- Swi2/Snf2-Related ATPase Homolog, Domino Homolog 1 3
- Swi2/Snf2-Related ATPase Homolog (S. Cerevisiae) 2
- Snf2-Related CREBBP Activator Protein 2
- Snf2-Related CBP Activator Protein 3
- Domino Homolog 1 (Drosophila) 2
- Snf2-Related CBP Activator 4
- Helicase SRCAP 3
External Ids for SRCAP Gene
- HGNC: 16974
- Entrez Gene: 10847
- Ensembl: ENSG00000080603
- OMIM: 611421
- UniProtKB: Q6ZRS2
Previous GeneCards Identifiers for SRCAP Gene
- GC16P030002
- GC16P031203
- GC16P030715
- GC16P030754
- GC16P030748
- GC16P030622
- GC16P030710
- GC16P028273
Summaries for SRCAP Gene
-
This gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encoded protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It can function as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription. Mutations in this gene cause Floating-Harbor syndrome, a rare disorder characterized by short stature, language deficits and dysmorphic facial features. [provided by RefSeq, Feb 2012]
GeneCards Summary for SRCAP Gene
SRCAP (Snf2 Related CREBBP Activator Protein) is a Protein Coding gene. Diseases associated with SRCAP include Floating-Harbor Syndrome and Rubinstein-Taybi Syndrome. Among its related pathways are Pathways Affected in Adenoid Cystic Carcinoma. GO annotations related to this gene include transcription coactivator activity and histone acetyltransferase activity. An important paralog of this gene is ENSG00000282034.
UniProtKB/Swiss-Prot for SRCAP Gene
-
Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRCAP Gene
Genomics for SRCAP Gene
Regulatory Elements for SRCAP Gene
Enhancers for SRCAP Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around SRCAP on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the SRCAP gene promoter:
Regulatory Element Products
Genomic Location for SRCAP Gene
- Chromosome:
- 16
- Start:
- 30,698,209 bp from pter
- End:
- 30,741,409 bp from pter
- Size:
- 43,201 bases
- Orientation:
- Plus strand
Genomic View for SRCAP Gene
Genes around SRCAP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p11.2 by Ensembl
- 16p11.2 by Entrez Gene
- 16p11.2 by HGNC
SRCAP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SRCAP Gene
Proteins for SRCAP Gene
-
Protein details for SRCAP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6ZRS2-SRCAP_HUMAN
- Recommended name:
- Helicase SRCAP
- Protein Accession:
- Q6ZRS2
- B0JZA6
- O15026
- Q7Z744
- Q9Y5L9
Protein attributes for SRCAP Gene
- Size:
- 3230 amino acids
- Molecular mass:
- 343555 Da
- Quaternary structure:
-
- Interacts with CREBBP and EP300. May be part of a complex containing SRCAP, CREBBP, CARM1 and GRIP1. Component of the chromatin-remodeling SRCAP complex composed of at least SRCAP, DMAP1, RUVBL1, RUVBL2, ACTL6A, YEATS4, VPS72, ACTR6 and ZNHIT1. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. Interacts with hepatitis C virus (HCV) NS5A and human adenovirus 2 DBP.
- SequenceCaution:
-
- Sequence=AAI59100.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for SRCAP Gene
Selected DME Specific Peptides for SRCAP Gene
- Q6ZRS2:
-
- DEMGLGKT
- NLTGADTV
- RKVCNHP
- TGTPLQN
- HRIGQTRDVHIYR
- GHRVLIF
- MGLGKTIQ
- FYDSDWNP
- HLIIVPTSV
- RCHRIGQ
- NGILADE
- LHKVLRP
Post-translational modifications for SRCAP Gene
Other Protein References for SRCAP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for SRCAP
- Novus Biologicals Antibodies for SRCAP
-
Abcam antibodies for SRCAP
- Invitrogen Antibodies for SRCAP
- antibodies-online Antibodies for SRCAP: See all 19
- Search GeneTex for Antibodies for SRCAP
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for SRCAP
- Origene Custom Protein Services for SRCAP
- Novus Biologicals proteins for SRCAP
- Search GeneTex for Proteins for SRCAP
Domains & Families for SRCAP Gene
Gene Families for SRCAP Gene
- HGNC:
Protein Domains for SRCAP Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SRCAP Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q6ZRS2- Family:
-
- Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.
Function for SRCAP Gene
Molecular function for SRCAP Gene
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=66 uM for ATP {ECO:0000269 PubMed:10347196};
- UniProtKB/Swiss-Prot Function:
- Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription.
Enzyme Numbers (IUBMB) for SRCAP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003713 | transcription coactivator activity | TAS | 10347196 |
| GO:0004386 | helicase activity | IEA | -- |
| GO:0004402 | histone acetyltransferase activity | TAS | 10347196 |
| GO:0005515 | protein binding | IPI | 10702287 |
Phenotypes for SRCAP Gene
- GenomeRNAi human phenotypes for SRCAP:
-
- Increased viability
- Increased gamma-H2AX phosphorylation
- Negative genetic interaction between MUS81-/- and MUS81+/+
- shRNA abundance <= 50%
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Increased shRNA abundance (Z-score > 2)
- Downregulation of NF-kappaB pathway after LMP1 stimulation
- Decreased viability
- Decreased shRNA abundance (Z-score < -2)
- Increased Nanog expression
- Negative genetic interaction between BLM-/- and BLM+/+
- Downregulation of NF-kappaB pathway after TNFalpha stimulation
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for SRCAP
-
-
ViGene Biosciences lentiviral particle packaged cDNA for SRCAP gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SRCAP gene
- Search ViGene Biosciences for SRCAP
CRISPR Products
-
OriGene CRISPR knockouts for SRCAP
-
Santa Cruz Biotechnology (SCBT) CRISPR for SRCAP
- GenScript: Design CRISPR guide RNA sequences for SRCAP
miRNA for SRCAP Gene
- miRTarBase miRNAs that target SRCAP
-
- hsa-mir-1229-3p (MIRT036303)
- hsa-mir-877-3p (MIRT036817)
- hsa-mir-744-5p (MIRT037418)
- hsa-mir-130b-5p (MIRT038290)
- hsa-mir-296-3p (MIRT038471)
- hsa-mir-615-3p (MIRT040165)
- hsa-mir-484 (MIRT041967)
- hsa-mir-320a (MIRT044623)
- hsa-mir-194-5p (MIRT044873)
- hsa-mir-27b-3p (MIRT046182)
- hsa-mir-197-3p (MIRT048104)
- hsa-mir-17-3p (MIRT050747)
- hsa-let-7c-5p (MIRT051752)
- hsa-let-7b-5p (MIRT051910)
- hsa-mir-450a-2-3p (MIRT498904)
- hsa-mir-6857-5p (MIRT498905)
- hsa-mir-6763-5p (MIRT498906)
- hsa-mir-3150a-3p (MIRT498907)
- hsa-mir-2110 (MIRT498908)
- hsa-mir-6810-5p (MIRT498909)
- hsa-mir-6825-5p (MIRT498910)
- hsa-mir-939-5p (MIRT498911)
- hsa-mir-1343-5p (MIRT498912)
- hsa-mir-3175 (MIRT498913)
- hsa-mir-7106-5p (MIRT498914)
- hsa-mir-765 (MIRT498915)
- hsa-mir-4644 (MIRT498916)
- hsa-mir-4306 (MIRT498917)
- hsa-mir-185-5p (MIRT498918)
- hsa-mir-3188 (MIRT498919)
- hsa-mir-4784 (MIRT498920)
- hsa-mir-3150b-3p (MIRT498921)
- hsa-mir-4259 (MIRT498922)
- hsa-mir-6758-5p (MIRT498923)
- hsa-mir-6856-5p (MIRT498924)
- hsa-mir-4311 (MIRT498925)
- hsa-mir-539-3p (MIRT613120)
- hsa-mir-485-3p (MIRT613121)
- hsa-mir-3941 (MIRT613122)
- hsa-mir-93-3p (MIRT613123)
- hsa-mir-6893-3p (MIRT613124)
- hsa-mir-370-3p (MIRT613125)
- hsa-mir-3620-3p (MIRT613126)
- hsa-mir-603 (MIRT613127)
- hsa-mir-362-3p (MIRT613128)
- hsa-mir-329-3p (MIRT613129)
- hsa-mir-8485 (MIRT613130)
- hsa-mir-3671 (MIRT642115)
- hsa-mir-372-5p (MIRT642116)
- hsa-mir-371a-5p (MIRT642117)
- hsa-mir-616-5p (MIRT642118)
- hsa-mir-373-5p (MIRT642119)
- hsa-mir-371b-5p (MIRT642120)
- hsa-mir-6849-3p (MIRT642121)
- hsa-mir-6877-3p (MIRT642122)
- hsa-mir-6819-3p (MIRT642123)
- hsa-mir-4446-5p (MIRT658823)
- hsa-mir-5006-3p (MIRT658824)
- hsa-mir-4755-5p (MIRT658825)
- hsa-mir-211-5p (MIRT658826)
- hsa-mir-204-5p (MIRT658827)
- hsa-mir-623 (MIRT658828)
- hsa-mir-3140-3p (MIRT658829)
- hsa-mir-4645-3p (MIRT658830)
- hsa-mir-6832-3p (MIRT658831)
- hsa-mir-6752-3p (MIRT658832)
- hsa-mir-2114-5p (MIRT658833)
- hsa-mir-378a-5p (MIRT678717)
- hsa-mir-6778-3p (MIRT678718)
- hsa-mir-6821-3p (MIRT678719)
- hsa-mir-6790-3p (MIRT678720)
- hsa-mir-18a-3p (MIRT678721)
- hsa-mir-324-3p (MIRT678722)
- hsa-mir-1913 (MIRT678723)
- hsa-mir-3653-5p (MIRT678724)
- hsa-mir-150-5p (MIRT678725)
- hsa-mir-7107-5p (MIRT678726)
- hsa-mir-1234-3p (MIRT678727)
- hsa-mir-1224-3p (MIRT678728)
- hsa-mir-186-3p (MIRT678729)
- hsa-mir-6513-3p (MIRT678730)
- hsa-mir-520h (MIRT678731)
- hsa-mir-520g-3p (MIRT678732)
- hsa-mir-512-3p (MIRT678733)
- hsa-mir-8079 (MIRT678734)
- hsa-mir-1245a (MIRT678735)
- hsa-mir-520e (MIRT678736)
- hsa-mir-520d-3p (MIRT678737)
- hsa-mir-520c-3p (MIRT678738)
- hsa-mir-520b (MIRT678739)
- hsa-mir-520a-3p (MIRT678740)
- hsa-mir-373-3p (MIRT678741)
- hsa-mir-372-3p (MIRT678742)
- hsa-mir-302e (MIRT678743)
- hsa-mir-302d-3p (MIRT678744)
- hsa-mir-302c-3p (MIRT678745)
- hsa-mir-302b-3p (MIRT678746)
- hsa-mir-302a-3p (MIRT678747)
- hsa-mir-93-5p (MIRT678748)
- hsa-mir-526b-3p (MIRT678749)
- hsa-mir-519d-3p (MIRT678750)
- hsa-mir-20b-5p (MIRT678751)
- hsa-mir-20a-5p (MIRT678752)
- hsa-mir-17-5p (MIRT678753)
- hsa-mir-106b-5p (MIRT678754)
- hsa-mir-106a-5p (MIRT678755)
- hsa-mir-6515-5p (MIRT704059)
- hsa-mir-2113 (MIRT704060)
- hsa-mir-9-3p (MIRT704061)
- hsa-mir-6797-5p (MIRT704062)
- hsa-mir-1249-5p (MIRT704063)
- hsa-mir-3135b (MIRT704064)
- hsa-mir-2467-3p (MIRT704065)
- hsa-mir-3616-3p (MIRT704066)
- hsa-mir-7843-5p (MIRT704067)
- hsa-mir-6879-5p (MIRT704068)
- hsa-mir-6735-5p (MIRT704069)
- hsa-mir-4632-5p (MIRT704070)
- hsa-mir-4436b-3p (MIRT704071)
- hsa-mir-320e (MIRT704072)
- hsa-mir-6776-3p (MIRT704073)
- hsa-mir-4429 (MIRT704074)
- hsa-mir-320d (MIRT704075)
- hsa-mir-320c (MIRT704076)
- hsa-mir-320b (MIRT704077)
miRNA Products
- Search ViGene Biosciences for SRCAP
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for SRCAP
- Browse OriGene Inhibitory RNA Products For SRCAP
-
ViGene Biosciences ready-to-package AAV shRNAs for SRCAP gene
Clone Products
-
OriGene ORF clones in human for SRCAP
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SRCAP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SRCAP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for SRCAP gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SRCAP gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SRCAP gene
No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for SRCAP Gene
Localization for SRCAP Gene
Subcellular locations from UniProtKB/Swiss-Prot for SRCAP Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| golgi apparatus | 5 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 10702287 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005794 | Golgi apparatus | IDA | -- |
| GO:0016604 | nuclear body | IDA | -- |
| GO:0043234 | protein complex | IDA | 14966270 |
Pathways & Interactions for SRCAP Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Pathways Affected in Adenoid Cystic Carcinoma | ||
Pathways by source for SRCAP Gene
1 BioSystems pathway for SRCAP Gene
Interacting Proteins for SRCAP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription from RNA polymerase II promoter | TAS | 10347196 |
| GO:0016032 | viral process | IEA | -- |
| GO:0016569 | covalent chromatin modification | IEA | -- |
No data available for SIGNOR curated interactions for SRCAP Gene
Transcripts for SRCAP Gene
mRNA/cDNA for SRCAP Gene
- (1) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (526) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SRCAP Gene
CRISPR Products
-
OriGene CRISPR knockouts for SRCAP
-
Santa Cruz Biotechnology (SCBT) CRISPR for SRCAP
- GenScript: Design CRISPR guide RNA sequences for SRCAP
miRNA Products
- Search ViGene Biosciences for SRCAP
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for SRCAP
- Browse OriGene Inhibitory RNA Products For SRCAP
-
ViGene Biosciences ready-to-package AAV shRNAs for SRCAP gene
Clone Products
-
OriGene ORF clones in human for SRCAP
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SRCAP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SRCAP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: |
| ExUns: | 22a | · | 22b | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28a | · | 28b | ^ | 29a | · | 29b | ^ | 30 | ^ | 31a | · | 31b | ^ | 32 | ^ | 33 | ^ | 34 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||
| SP6: |
Expression for SRCAP Gene
This gene is overexpressed in Ovary (16.3), Peripheral blood mononuclear cells (13.9), Blymphocyte (8.5), and Lung (7.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SRCAP Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of SRCAP Gene:
SRCAPSOURCE GeneReport for Unigene cluster for SRCAP Gene:
Hs.620916Evidence on tissue expression from TISSUES for SRCAP Gene
- Nervous system(4.7)
- Eye(3.1)
- Intestine(2.5)
- Lung(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for SRCAP Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- lymphatic
- nervous
- skeletal muscle
- skeleton
Organs:
Head and neck:
- brain
- cheek
- chin
- ear
- eye
- eyelid
- face
- forehead
- head
- jaw
- larynx
- lip
- mandible
- maxilla
- mouth
- neck
- nose
- outer ear
- scalp
- skull
- vocal cord
Thorax:
- chest wall
- clavicle
- rib
- rib cage
- scapula
- sternum
Abdomen:
- intestine
- large intestine
- small intestine
Pelvis:
- pelvis
- rectum
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- blood
- blood vessel
- hair
- skin
- spinal column
- vertebrae
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for SRCAP
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SRCAP Gene
Orthologs for SRCAP Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SRCAP 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | SRCAP 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| mouse (Mus musculus) |
Mammalia | Srcap 34 16 35 35 |
|
||
| dog (Canis familiaris) |
Mammalia | SRCAP 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Srcap 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | SRCAP 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | SRCAP 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.15976 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.15109 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | srcap 35 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | dom 36 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | Y111B2A.23 36 |
|
|
|
| ssl-1 35 |
|
OneToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SWR1 35 37 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.10052 34 |
|
- Species where no ortholog for SRCAP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for SRCAP Gene
(3) SIMAP similar genes for SRCAP Gene using alignment to 4 proteins:
Variants for SRCAP Gene
| SNP ID | Clin | Chr 16 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs199469464 | Pathogenic | 30,737,370(+) | GGCCT(C/T)GACCC | reference, stop-gained | |
| rs199469465 | Pathogenic | 30,737,343(+) | GGGAG(C/T)GAGTT | reference, stop-gained | |
| rs199469466 | Pathogenic | 30,737,589(+) | CAGCC(-/C)AAACC | reference, frameshift-variant | |
| rs587776938 | Pathogenic | 30,737,903(+) | AAGAG(-/G)CAGGA | reference, frameshift-variant | |
| rs587777656 | Pathogenic | 30,736,616(+) | TCAAA(C/T)AGGCA | reference, stop-gained |
Residual Variation Intolerance Score:
0.229% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.36;
63.38% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for SRCAP Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRCAP Gene
Disorders for SRCAP Gene
(4) MalaCards diseases for SRCAP Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| floating-harbor syndrome |
|
|
| rubinstein-taybi syndrome |
|
|
| tethered spinal cord syndrome |
|
|
| 3-m syndrome 1 |
|
|
Search SRCAP in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
SRCAP_HUMAN- Floating-Harbor syndrome (FLHS) [MIM:136140]: A rare genetic disorder characterized by proportionate short stature, delayed bone age, delayed speech development, and typical facial features. The face is triangular with deep-set eyes, long eyelashes, bulbous nose, wide columella, short philtrum, and thin lips. {ECO:0000269 PubMed:22265015}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for SRCAP
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- SRCAP
No data available for Genatlas for SRCAP Gene
Publications for SRCAP Gene
- Identification of a novel SNF2/SWI2 protein family member, SRCAP, which interacts with CREB-binding protein. (PMID: 10347196) Johnston H. … Chrivia J. (J. Biol. Chem. 1999) 2 3 4 22 64
- SNF2-related CBP activator protein (SRCAP) functions as a coactivator of steroid receptor-mediated transcription through synergistic interactions with CARM-1 and GRIP-1. (PMID: 14500758) Monroy M.A. … Chrivia J.C. (Mol. Endocrinol. 2003) 3 4 22 64
- Adenovirus DNA binding protein interacts with the SNF2-related CBP activator protein (SrCap) and inhibits SrCap-mediated transcription. (PMID: 11581372) Xu X. … Yaciuk P. (J. Virol. 2001) 3 4 22 64
- The human SRCAP chromatin remodeling complex promotes DNA-end resection. (PMID: 25176633) Dong S. … Huang J. (Curr. Biol. 2014) 2 3 64
- Mutations in SRCAP, encoding SNF2-related CREBBP activator protein, cause Floating-Harbor syndrome. (PMID: 22265015) Hood R.L. … Boycott K.M. (Am. J. Hum. Genet. 2012) 3 4 64
Products for SRCAP Gene
- Browse R&D Systems for Antibodies
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- Custom Antibody ServicesOriGene Antibodies for SRCAP
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- Novus Biologicals Antibodies for SRCAP
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- Abcam antibodies for SRCAP
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- Search knockout validated antibodies
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- Invitrogen Antibodies for SRCAP
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
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- ViGene Biosciences adenoviral particle packaged cDNA for SRCAP gene
- ViGene Biosciences lentiviral particle packaged cDNA for SRCAP gene
- ViGene Biosciences ready-to-package AAV shRNAs for SRCAP gene
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- Cyagen custom Knockout/knockin (KOKI) mouse models for SRCAP
- VectorBuilder custom plasmid, inducible vectors for SRCAP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SRCAP
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for SRCAP Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer