Aliases for SRCAP Gene
External Ids for SRCAP Gene
Previous GeneCards Identifiers for SRCAP Gene
This gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encoded protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It can function as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription. Mutations in this gene cause Floating-Harbor syndrome, a rare disorder characterized by short stature, language deficits and dysmorphic facial features. [provided by RefSeq, Feb 2012]
GeneCards Summary for SRCAP Gene
SRCAP (Snf2-Related CREBBP Activator Protein) is a Protein Coding gene. Diseases associated with SRCAP include Floating-Harbor Syndrome and Tethered Spinal Cord Syndrome. GO annotations related to this gene include transcription coactivator activity and histone acetyltransferase activity. An important paralog of this gene is EP400NL.
UniProtKB/Swiss-Prot for SRCAP Gene
Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription.