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Aliases for SRCAP Gene

Aliases for SRCAP Gene

  • Snf2-Related CREBBP Activator Protein 2 3
  • Domino Homolog 2 3 4
  • KIAA0309 4 6
  • FLHS 3 6
  • SWR1 3 6
  • Swi2/Snf2-Related ATPase Homolog, Domino Homolog 1 3
  • Swi2/Snf2-Related ATPase Homolog (S. Cerevisiae) 2
  • Snf2-Related CBP Activator Protein 3
  • Domino Homolog 1 (Drosophila) 2
  • Snf2-Related CBP Activator 4
  • Helicase SRCAP 3
  • EC 3.6.4.- 4
  • EC 3.6.1 63
  • DOMO1 3
  • EAF1 3

External Ids for SRCAP Gene

Previous GeneCards Identifiers for SRCAP Gene

  • GC16P030002
  • GC16P031203
  • GC16P030715
  • GC16P030754
  • GC16P030748
  • GC16P030622
  • GC16P028273

Summaries for SRCAP Gene

Entrez Gene Summary for SRCAP Gene

  • This gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encoded protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It can function as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription. Mutations in this gene cause Floating-Harbor syndrome, a rare disorder characterized by short stature, language deficits and dysmorphic facial features. [provided by RefSeq, Feb 2012]

GeneCards Summary for SRCAP Gene

SRCAP (Snf2-Related CREBBP Activator Protein) is a Protein Coding gene. Diseases associated with SRCAP include floating-harbor syndrome and eaf. GO annotations related to this gene include transcription coactivator activity and helicase activity. An important paralog of this gene is EP400NL.

UniProtKB/Swiss-Prot for SRCAP Gene

  • Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription.

Gene Wiki entry for SRCAP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRCAP Gene

Genomics for SRCAP Gene

Regulatory Elements for SRCAP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SRCAP Gene

30,698,209 bp from pter
30,745,194 bp from pter
46,986 bases
Plus strand

Genomic View for SRCAP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SRCAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRCAP Gene

Proteins for SRCAP Gene

  • Protein details for SRCAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Helicase SRCAP
    Protein Accession:
    Secondary Accessions:
    • B0JZA6
    • O15026
    • Q7Z744
    • Q9Y5L9

    Protein attributes for SRCAP Gene

    3230 amino acids
    Molecular mass:
    343555 Da
    Quaternary structure:
    • Interacts with CREBBP and EP300. May be part of a complex containing SRCAP, CREBBP, CARM1 and GRIP1. Component of the chromatin-remodeling SRCAP complex composed of at least SRCAP, DMAP1, RUVBL1, RUVBL2, ACTL6A, YEATS4, VPS72, ACTR6 and ZNHIT1. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. Interacts with hepatitis C virus (HCV) NS5A and human adenovirus 2 DBP.
    • Sequence=AAI59100.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SRCAP Gene


neXtProt entry for SRCAP Gene

Proteomics data for SRCAP Gene at MOPED

Post-translational modifications for SRCAP Gene

Other Protein References for SRCAP Gene

Domains for SRCAP Gene

Suggested Antigen Peptide Sequences for SRCAP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q6ZRS2
  • Contains 3 A.T hook DNA-binding domains.
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
  • Contains 1 HSA domain.
  • Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.
genes like me logo Genes that share domains with SRCAP: view

No data available for Gene Families for SRCAP Gene

Function for SRCAP Gene

Molecular function for SRCAP Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=66 uM for ATP {ECO:0000269 PubMed:10347196};
UniProtKB/Swiss-Prot Function:
Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription.

Enzyme Numbers (IUBMB) for SRCAP Gene

Gene Ontology (GO) - Molecular Function for SRCAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003713 transcription coactivator activity TAS 10347196
GO:0004386 helicase activity IEA --
GO:0004402 histone acetyltransferase activity TAS 10347196
GO:0005515 protein binding IPI 10702287
genes like me logo Genes that share ontologies with SRCAP: view
genes like me logo Genes that share phenotypes with SRCAP: view

Animal Model Products

CRISPR Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for SRCAP Gene

Localization for SRCAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRCAP Gene

Subcellular locations from

Jensen Localization Image for SRCAP Gene COMPARTMENTS Subcellular localization image for SRCAP gene
Compartment Confidence
nucleus 5
golgi apparatus 4
cytosol 1

Gene Ontology (GO) - Cellular Components for SRCAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0016021 integral component of membrane --
GO:0043234 protein complex IDA 14966270
genes like me logo Genes that share ontologies with SRCAP: view

Pathways for SRCAP Gene

SuperPathways for SRCAP Gene

No Data Available

Gene Ontology (GO) - Biological Process for SRCAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 10347196
GO:0009607 response to biotic stimulus --
GO:0016032 viral process IEA --
GO:0016573 histone acetylation TAS 10347196
genes like me logo Genes that share ontologies with SRCAP: view

No data available for Pathways by source for SRCAP Gene

Transcripts for SRCAP Gene

Unigene Clusters for SRCAP Gene

Snf2-related CREBBP activator protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SRCAP

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRCAP Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP2: -
SP5: -

ExUns: 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29a · 29b ^ 30 ^ 31a · 31b ^ 32 ^ 33 ^ 34
SP1: - -
SP2: - -

Relevant External Links for SRCAP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SRCAP Gene

mRNA expression in normal human tissues for SRCAP Gene

Protein differential expression in normal tissues for SRCAP Gene

This gene is overexpressed in Ovary (16.3), Peripheral blood mononuclear cells (13.9), Blymphocyte (8.5), and Lung (7.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SRCAP Gene

SOURCE GeneReport for Unigene cluster for SRCAP Gene Hs.620916

genes like me logo Genes that share expressions with SRCAP: view

Expression partners for SRCAP Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SRCAP Gene

Orthologs for SRCAP Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SRCAP Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SRCAP 35
  • 91.02 (n)
  • 92.57 (a)
  • 92 (a)
(Canis familiaris)
Mammalia SRCAP 35
  • 87.25 (n)
  • 86.55 (a)
  • 84 (a)
(Mus musculus)
Mammalia Srcap 35
  • 87.43 (n)
  • 89.63 (a)
Srcap 16
Srcap 36
  • 92 (a)
Srcap 36
  • 65 (a)
(Pan troglodytes)
Mammalia SRCAP 35
  • 99.35 (n)
  • 99.07 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Srcap 35
  • 85.21 (n)
  • 86.73 (a)
(Monodelphis domestica)
Mammalia SRCAP 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 88 (a)
-- 36
  • 55 (a)
(Anolis carolinensis)
Reptilia SRCAP 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15976 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15109 35
(Danio rerio)
Actinopterygii srcap 36
  • 33 (a)
fruit fly
(Drosophila melanogaster)
Insecta dom 37
  • 71 (a)
dom 36
  • 25 (a)
(Caenorhabditis elegans)
Secernentea Y111B2A.23 37
  • 53 (a)
ssl-1 36
  • 26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWR1 36
  • 29 (a)
SWR1 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10052 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
Species with no ortholog for SRCAP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRCAP Gene

Gene Tree for SRCAP (if available)
Gene Tree for SRCAP (if available)

Paralogs for SRCAP Gene

Paralogs for SRCAP Gene

Selected SIMAP similar genes for SRCAP Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SRCAP: view

Variants for SRCAP Gene

Sequence variations from dbSNP and Humsavar for SRCAP Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1348039 -- 30,715,646(+) CTTCC(A/G)TGTCA intron-variant
rs1470129 -- 30,721,085(-) GACCC(C/G)TGTCC intron-variant
rs1530202 -- 30,701,668(+) tttct(G/T)tcagc intron-variant
rs2053426 -- 30,728,821(-) TATCA(A/G)TGAGA intron-variant
rs2289442 -- 30,728,598(-) CACTC(A/G)ACTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRCAP Gene

Variant ID Type Subtype PubMed ID
nsv469724 CNV Loss 16826518
nsv833188 CNV Loss 17160897
nsv905728 CNV Loss 21882294
nsv905729 CNV Loss 21882294
nsv1785 CNV Insertion 18451855
esv33681 CNV Loss 17666407

Relevant External Links for SRCAP Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRCAP Gene

Disorders for SRCAP Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SRCAP Gene in MalaCards »

(3) Diseases for SRCAP Gene including...

(1) OMIM Diseases for SRCAP Gene (611421)


  • Floating-Harbor syndrome (FLHS) [MIM:136140]: A rare genetic disorder characterized by proportionate short stature, delayed bone age, delayed speech development, and typical facial features. The face is triangular with deep-set eyes, long eyelashes, bulbous nose, wide columella, short philtrum, and thin lips. {ECO:0000269 PubMed:22265015}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for SRCAP Gene

genes like me logo Genes that share disorders with SRCAP: view

No data available for Novoseek inferred disease relationships , Genatlas and External Links for SRCAP Gene

Publications for SRCAP Gene

  1. Identification of a novel SNF2/SWI2 protein family member, SRCAP, which interacts with CREB-binding protein. (PMID: 10347196) Johnston H. … Chrivia J. (J. Biol. Chem. 1999) 2 3 4 23
  2. Adenovirus DNA binding protein interacts with the SNF2-related CBP activator protein (SrCap) and inhibits SrCap-mediated transcription. (PMID: 11581372) Xu X. … Yaciuk P. (J. Virol. 2001) 3 4 23
  3. SNF2-related CBP activator protein (SRCAP) functions as a coactivator of steroid receptor-mediated transcription through synergistic interactions with CARM-1 and GRIP-1. (PMID: 14500758) Monroy M.A. … Chrivia J.C. (Mol. Endocrinol. 2003) 3 4 23
  4. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 2 3 4
  5. Hepatitis C virus NS5A protein modulates transcription through a novel cellular transcription factor SRCAP. (PMID: 10702287) Ghosh A.K. … Ray R.B. (J. Biol. Chem. 2000) 3 4

Products for SRCAP Gene

Sources for SRCAP Gene

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