Aliases for SRCAP Gene
Aliases for SRCAP Gene
- Snf2 Related CREBBP Activator Protein 2 3 5
- Domino Homolog 2 3 4
- Swi2/Snf2-Related ATPase Homolog, Domino Homolog 1 3
- Swi2/Snf2-Related ATPase Homolog (S. Cerevisiae) 2
- Snf2-Related CREBBP Activator Protein 2
- Snf2-Related CBP Activator Protein 3
- Domino Homolog 1 (Drosophila) 2
- Snf2-Related CBP Activator 4
- Helicase SRCAP 3
External Ids for SRCAP Gene
- HGNC: 16974
- Entrez Gene: 10847
- Ensembl: ENSG00000080603
- OMIM: 611421
- UniProtKB: Q6ZRS2
Previous GeneCards Identifiers for SRCAP Gene
- GC16P030002
- GC16P031203
- GC16P030715
- GC16P030754
- GC16P030748
- GC16P030622
- GC16P030710
- GC16P028273
Summaries for SRCAP Gene
-
This gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encoded protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It can function as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription. Mutations in this gene cause Floating-Harbor syndrome, a rare disorder characterized by short stature, language deficits and dysmorphic facial features. [provided by RefSeq, Feb 2012]
GeneCards Summary for SRCAP Gene
SRCAP (Snf2 Related CREBBP Activator Protein) is a Protein Coding gene. Diseases associated with SRCAP include Floating-Harbor Syndrome and Tethered Spinal Cord Syndrome. GO annotations related to this gene include transcription coactivator activity and histone acetyltransferase activity. An important paralog of this gene is ENSG00000282034.
UniProtKB/Swiss-Prot for SRCAP Gene
-
Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRCAP Gene
Genomics for SRCAP Gene
Regulatory Elements for SRCAP Gene
Enhancers for SRCAP Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around SRCAP on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the SRCAP gene promoter:
Regulatory Element Products
Genomic Location for SRCAP Gene
- Chromosome:
- 16
- Start:
- 30,698,209 bp from pter
- End:
- 30,741,409 bp from pter
- Size:
- 43,201 bases
- Orientation:
- Plus strand
Genomic View for SRCAP Gene
Genes around SRCAP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p11.2 by Ensembl
- 16p11.2 by Entrez Gene
- 16p11.2 by HGNC
SRCAP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SRCAP Gene
Proteins for SRCAP Gene
-
Protein details for SRCAP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6ZRS2-SRCAP_HUMAN
- Recommended name:
- Helicase SRCAP
- Protein Accession:
- Q6ZRS2
- B0JZA6
- O15026
- Q7Z744
- Q9Y5L9
Protein attributes for SRCAP Gene
- Size:
- 3230 amino acids
- Molecular mass:
- 343555 Da
- Quaternary structure:
-
- Interacts with CREBBP and EP300. May be part of a complex containing SRCAP, CREBBP, CARM1 and GRIP1. Component of the chromatin-remodeling SRCAP complex composed of at least SRCAP, DMAP1, RUVBL1, RUVBL2, ACTL6A, YEATS4, VPS72, ACTR6 and ZNHIT1. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. Interacts with hepatitis C virus (HCV) NS5A and human adenovirus 2 DBP.
- SequenceCaution:
-
- Sequence=AAI59100.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for SRCAP Gene
Selected DME Specific Peptides for SRCAP Gene
- Q6ZRS2:
-
- DEMGLGKT
- NLTGADTV
- RKVCNHP
- TGTPLQN
- HRIGQTRDVHIYR
- GHRVLIF
- MGLGKTIQ
- FYDSDWNP
- HLIIVPTSV
- RCHRIGQ
- NGILADE
- LHKVLRP
Post-translational modifications for SRCAP Gene
Other Protein References for SRCAP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for SRCAP
- Novus Biologicals Antibodies for SRCAP
-
Abcam antibodies for SRCAP
- Invitrogen Antibodies for SRCAP
- antibodies-online Antibodies for SRCAP: See all 19
- Search GeneTex for Antibodies for SRCAP
-
St John's Laboratory Antibodies for SRCAP
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for SRCAP
- Origene Custom Protein Services for SRCAP
- Novus Biologicals proteins for SRCAP
- Search GeneTex for Proteins for SRCAP
Assay Products
Domains & Families for SRCAP Gene
Gene Families for SRCAP Gene
- HGNC:
Protein Domains for SRCAP Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SRCAP Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q6ZRS2UniProtKB/Swiss-Prot:
SRCAP_HUMAN :- Contains 3 A.T hook DNA-binding domains.
- Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.
- Domain:
-
- Contains 3 A.T hook DNA-binding domains.
- Contains 1 helicase ATP-binding domain.
- Contains 1 helicase C-terminal domain.
- Contains 1 HSA domain.
- Family:
-
- Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.
Function for SRCAP Gene
Molecular function for SRCAP Gene
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=66 uM for ATP {ECO:0000269 PubMed:10347196};
- UniProtKB/Swiss-Prot Function:
- Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription.
Enzyme Numbers (IUBMB) for SRCAP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003713 | transcription coactivator activity | TAS | 10347196 |
| GO:0004386 | helicase activity | IEA | -- |
| GO:0004402 | histone acetyltransferase activity | TAS | 10347196 |
| GO:0005515 | protein binding | IPI | 10702287 |
Phenotypes for SRCAP Gene
- GenomeRNAi human phenotypes for SRCAP:
-
- Increased viability
- Increased gamma-H2AX phosphorylation
- Negative genetic interaction between MUS81-/- and MUS81+/+
- shRNA abundance <= 50%
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Increased shRNA abundance (Z-score > 2)
- Downregulation of NF-kappaB pathway after LMP1 stimulation
- Decreased viability
- Decreased shRNA abundance (Z-score < -2)
- Increased Nanog expression
- Negative genetic interaction between BLM-/- and BLM+/+
- Downregulation of NF-kappaB pathway after TNFalpha stimulation
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for SRCAP
-
-
ViGene Biosciences lentiviral particle packaged cDNA for SRCAP gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SRCAP gene
- Search ViGene Biosciences for SRCAP
CRISPR Products
-
OriGene CRISPR knockouts for SRCAP
- GenScript: Design CRISPR guide RNA sequences for SRCAP
miRNA for SRCAP Gene
- miRTarBase miRNAs that target SRCAP
-
- hsa-mir-1229-3p (MIRT036303)
- hsa-mir-877-3p (MIRT036817)
- hsa-mir-744-5p (MIRT037418)
- hsa-mir-130b-5p (MIRT038290)
- hsa-mir-296-3p (MIRT038471)
- hsa-mir-615-3p (MIRT040165)
- hsa-mir-484 (MIRT041967)
- hsa-mir-320a (MIRT044623)
- hsa-mir-194-5p (MIRT044873)
- hsa-mir-27b-3p (MIRT046182)
- hsa-mir-197-3p (MIRT048104)
- hsa-mir-17-3p (MIRT050747)
- hsa-let-7c-5p (MIRT051752)
- hsa-let-7b-5p (MIRT051910)
- hsa-mir-450a-2-3p (MIRT498904)
- hsa-mir-6857-5p (MIRT498905)
- hsa-mir-6763-5p (MIRT498906)
- hsa-mir-3150a-3p (MIRT498907)
- hsa-mir-2110 (MIRT498908)
- hsa-mir-6810-5p (MIRT498909)
- hsa-mir-6825-5p (MIRT498910)
- hsa-mir-939-5p (MIRT498911)
- hsa-mir-1343-5p (MIRT498912)
- hsa-mir-3175 (MIRT498913)
- hsa-mir-7106-5p (MIRT498914)
- hsa-mir-765 (MIRT498915)
- hsa-mir-4644 (MIRT498916)
- hsa-mir-4306 (MIRT498917)
- hsa-mir-185-5p (MIRT498918)
- hsa-mir-3188 (MIRT498919)
- hsa-mir-4784 (MIRT498920)
- hsa-mir-3150b-3p (MIRT498921)
- hsa-mir-4259 (MIRT498922)
- hsa-mir-6758-5p (MIRT498923)
- hsa-mir-6856-5p (MIRT498924)
- hsa-mir-4311 (MIRT498925)
- hsa-mir-539-3p (MIRT613120)
- hsa-mir-485-3p (MIRT613121)
- hsa-mir-3941 (MIRT613122)
- hsa-mir-93-3p (MIRT613123)
- hsa-mir-6893-3p (MIRT613124)
- hsa-mir-370-3p (MIRT613125)
- hsa-mir-3620-3p (MIRT613126)
- hsa-mir-603 (MIRT613127)
- hsa-mir-362-3p (MIRT613128)
- hsa-mir-329-3p (MIRT613129)
- hsa-mir-8485 (MIRT613130)
- hsa-mir-3671 (MIRT642115)
- hsa-mir-372-5p (MIRT642116)
- hsa-mir-371a-5p (MIRT642117)
- hsa-mir-616-5p (MIRT642118)
- hsa-mir-373-5p (MIRT642119)
- hsa-mir-371b-5p (MIRT642120)
- hsa-mir-6849-3p (MIRT642121)
- hsa-mir-6877-3p (MIRT642122)
- hsa-mir-6819-3p (MIRT642123)
- hsa-mir-4446-5p (MIRT658823)
- hsa-mir-5006-3p (MIRT658824)
- hsa-mir-4755-5p (MIRT658825)
- hsa-mir-211-5p (MIRT658826)
- hsa-mir-204-5p (MIRT658827)
- hsa-mir-623 (MIRT658828)
- hsa-mir-3140-3p (MIRT658829)
- hsa-mir-4645-3p (MIRT658830)
- hsa-mir-6832-3p (MIRT658831)
- hsa-mir-6752-3p (MIRT658832)
- hsa-mir-2114-5p (MIRT658833)
- hsa-mir-378a-5p (MIRT678717)
- hsa-mir-6778-3p (MIRT678718)
- hsa-mir-6821-3p (MIRT678719)
- hsa-mir-6790-3p (MIRT678720)
- hsa-mir-18a-3p (MIRT678721)
- hsa-mir-324-3p (MIRT678722)
- hsa-mir-1913 (MIRT678723)
- hsa-mir-3653-5p (MIRT678724)
- hsa-mir-150-5p (MIRT678725)
- hsa-mir-7107-5p (MIRT678726)
- hsa-mir-1234-3p (MIRT678727)
- hsa-mir-1224-3p (MIRT678728)
- hsa-mir-186-3p (MIRT678729)
- hsa-mir-6513-3p (MIRT678730)
- hsa-mir-520h (MIRT678731)
- hsa-mir-520g-3p (MIRT678732)
- hsa-mir-512-3p (MIRT678733)
- hsa-mir-8079 (MIRT678734)
- hsa-mir-1245a (MIRT678735)
- hsa-mir-520e (MIRT678736)
- hsa-mir-520d-3p (MIRT678737)
- hsa-mir-520c-3p (MIRT678738)
- hsa-mir-520b (MIRT678739)
- hsa-mir-520a-3p (MIRT678740)
- hsa-mir-373-3p (MIRT678741)
- hsa-mir-372-3p (MIRT678742)
- hsa-mir-302e (MIRT678743)
- hsa-mir-302d-3p (MIRT678744)
- hsa-mir-302c-3p (MIRT678745)
- hsa-mir-302b-3p (MIRT678746)
- hsa-mir-302a-3p (MIRT678747)
- hsa-mir-93-5p (MIRT678748)
- hsa-mir-526b-3p (MIRT678749)
- hsa-mir-519d-3p (MIRT678750)
- hsa-mir-20b-5p (MIRT678751)
- hsa-mir-20a-5p (MIRT678752)
- hsa-mir-17-5p (MIRT678753)
- hsa-mir-106b-5p (MIRT678754)
- hsa-mir-106a-5p (MIRT678755)
- hsa-mir-6515-5p (MIRT704059)
- hsa-mir-2113 (MIRT704060)
- hsa-mir-9-3p (MIRT704061)
- hsa-mir-6797-5p (MIRT704062)
- hsa-mir-1249-5p (MIRT704063)
- hsa-mir-3135b (MIRT704064)
- hsa-mir-2467-3p (MIRT704065)
- hsa-mir-3616-3p (MIRT704066)
- hsa-mir-7843-5p (MIRT704067)
- hsa-mir-6879-5p (MIRT704068)
- hsa-mir-6735-5p (MIRT704069)
- hsa-mir-4632-5p (MIRT704070)
- hsa-mir-4436b-3p (MIRT704071)
- hsa-mir-320e (MIRT704072)
- hsa-mir-6776-3p (MIRT704073)
- hsa-mir-4429 (MIRT704074)
- hsa-mir-320d (MIRT704075)
- hsa-mir-320c (MIRT704076)
- hsa-mir-320b (MIRT704077)
miRNA Products
- Search ViGene Biosciences for SRCAP
Inhibitory RNA Products
- Origene shRNA, RNAi, and siRNA products in human, mouse, rat for SRCAP
- Browse OriGene Inhibitory RNA Products For SRCAP
-
ViGene Biosciences ready-to-package AAV shRNAs for SRCAP gene
Clone Products
-
OriGene ORF clones in human for SRCAP
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SRCAP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SRCAP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for SRCAP gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SRCAP gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SRCAP gene
Flow Cytometry Products
No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for SRCAP Gene
Localization for SRCAP Gene
Subcellular locations from UniProtKB/Swiss-Prot for SRCAP Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| golgi apparatus | 5 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 10702287 |
| GO:0005794 | Golgi apparatus | IDA | -- |
| GO:0043234 | protein complex | IDA | 14966270 |
| GO:0048471 | perinuclear region of cytoplasm | IDA | 10702287 |
Pathways & Interactions for SRCAP Gene
No Data Available
Interacting Proteins for SRCAP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription from RNA polymerase II promoter | TAS | 10347196 |
| GO:0016032 | viral process | IEA | -- |
| GO:0016569 | covalent chromatin modification | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for SRCAP Gene
Transcripts for SRCAP Gene
mRNA/cDNA for SRCAP Gene
- (1) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (526) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SRCAP Gene
CRISPR Products
-
OriGene CRISPR knockouts for SRCAP
- GenScript: Design CRISPR guide RNA sequences for SRCAP
miRNA Products
- Search ViGene Biosciences for SRCAP
Inhibitory RNA Products
- Origene shRNA, RNAi, and siRNA products in human, mouse, rat for SRCAP
- Browse OriGene Inhibitory RNA Products For SRCAP
-
ViGene Biosciences ready-to-package AAV shRNAs for SRCAP gene
Clone Products
-
OriGene ORF clones in human for SRCAP
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SRCAP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SRCAP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: |
| ExUns: | 22a | · | 22b | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28a | · | 28b | ^ | 29a | · | 29b | ^ | 30 | ^ | 31a | · | 31b | ^ | 32 | ^ | 33 | ^ | 34 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||
| SP6: |
Expression for SRCAP Gene
This gene is overexpressed in Ovary (16.3), Peripheral blood mononuclear cells (13.9), Blymphocyte (8.5), and Lung (7.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SRCAP Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of SRCAP Gene:
SRCAPSOURCE GeneReport for Unigene cluster for SRCAP Gene:
Hs.620916Primer Products
-
OriGene qPCR primer pairs for SRCAP
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SRCAP Gene
Orthologs for SRCAP Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SRCAP 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | SRCAP 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| mouse (Mus musculus) |
Mammalia | Srcap 34 16 35 35 |
|
||
| dog (Canis familiaris) |
Mammalia | SRCAP 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Srcap 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | SRCAP 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | SRCAP 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.15976 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.15109 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | srcap 35 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | dom 36 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | Y111B2A.23 36 |
|
|
|
| ssl-1 35 |
|
OneToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SWR1 35 37 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.10052 34 |
|
- Species where no ortholog for SRCAP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for SRCAP Gene
(3) SIMAP similar genes for SRCAP Gene using alignment to 4 proteins:
Variants for SRCAP Gene
| SNP ID | Clin | Chr 16 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs199469464 | Pathogenic | 30,737,370(+) | GGCCT(C/T)GACCC | reference, stop-gained | |
| rs199469465 | Pathogenic | 30,737,343(+) | GGGAG(C/T)GAGTT | reference, stop-gained | |
| rs199469466 | Pathogenic | 30,737,589(+) | CAGCC(-/C)AAACC | reference, frameshift-variant | |
| rs587776938 | Pathogenic | 30,737,903(+) | AAGAG(-/G)CAGGA | reference, frameshift-variant | |
| rs587777656 | Pathogenic | 30,736,616(+) | TCAAA(C/T)AGGCA | reference, stop-gained |
Residual Variation Intolerance Score:
0.229% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.36;
63.38% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for SRCAP Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRCAP Gene
Disorders for SRCAP Gene
(4) MalaCards diseases for SRCAP Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| floating-harbor syndrome |
|
|
| tethered spinal cord syndrome |
|
|
| rubinstein-taybi syndrome |
|
|
| 3-m syndrome 1 |
|
|
Search SRCAP in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
SRCAP_HUMAN- Floating-Harbor syndrome (FLHS) [MIM:136140]: A rare genetic disorder characterized by proportionate short stature, delayed bone age, delayed speech development, and typical facial features. The face is triangular with deep-set eyes, long eyelashes, bulbous nose, wide columella, short philtrum, and thin lips. {ECO:0000269 PubMed:22265015}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for SRCAP
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- SRCAP
No data available for Genatlas for SRCAP Gene
Publications for SRCAP Gene
- Identification of a novel SNF2/SWI2 protein family member, SRCAP, which interacts with CREB-binding protein. (PMID: 10347196) Johnston H. … Chrivia J. (J. Biol. Chem. 1999) 2 3 4 22 64
- SNF2-related CBP activator protein (SRCAP) functions as a coactivator of steroid receptor-mediated transcription through synergistic interactions with CARM-1 and GRIP-1. (PMID: 14500758) Monroy M.A. … Chrivia J.C. (Mol. Endocrinol. 2003) 3 4 22 64
- Adenovirus DNA binding protein interacts with the SNF2-related CBP activator protein (SrCap) and inhibits SrCap-mediated transcription. (PMID: 11581372) Xu X. … Yaciuk P. (J. Virol. 2001) 3 4 22 64
- The human SRCAP chromatin remodeling complex promotes DNA-end resection. (PMID: 25176633) Dong S. … Huang J. (Curr. Biol. 2014) 2 3 64
- Mutations in SRCAP, encoding SNF2-related CREBBP activator protein, cause Floating-Harbor syndrome. (PMID: 22265015) Hood R.L. … Boycott K.M. (Am. J. Hum. Genet. 2012) 3 4 64
Products for SRCAP Gene
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- Mammalian expression: PiggyBac
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Sources for SRCAP Gene
- (1) GeneCards
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