SRCAP Gene
protein-coding GIFtS: 57
GCID: GC16P030710
|
|
Snf2-related CREBBP activator protein
| |
Aliases
for SRCAP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Snf2-Related CREBBP Activator Protein1 2 | | Helicase SRCAP2 | | SWR11 2 5 | | Snf2-Related CBP Activator Protein2 | | KIAA03091 3 5 | | Swi2/Snf2-Related ATPase Homolog, Domino Homolog 12 | | DOMO11 2 | | EC 3.6.4.-3 | | EAF11 2 | | Snf2-Related CBP Activator3 | | Domino Homolog 22 3 | | EC 3.6.18 | | FLHS2 | | |
Export aliases for SRCAP gene to outside databasesPrevious GC identifers: GC16P030002 GC16P031203 GC16P030715 GC16P030754 GC16P030748 GC16P030622 GC16P028273 |
Summaries
for SRCAP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SRCAP:
This gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encodedprotein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It canfunction as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription.Mutations in this gene cause Floating-Harbor syndrome, a rare disorder characterized by short stature, languagedeficits and dysmorphic facial features. (provided by RefSeq, Feb 2012)
UniProtKB/Swiss-Prot: SRCAP_HUMAN, Q6ZRS2Function: Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimersfor nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as acoactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription
Gene Wiki entry for SRCAP
|
Genomic Views
for SRCAP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SRCAP gene promoter:
AhR AML1a C/EBPalpha HEN1 CREB deltaCREB Zic1 c-Myb Pax-4a ATF
Other transcription factors
Search SABiosciences Chromatin IP Primers for SRCAP
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRCAP |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p11.2SRCAP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P030710: view genomic region
(about GC identifiers)
Start:
|
30,709,530 bp from pter |
End:
|
30,755,602 bp from pter |
Size:
|
46,073 bases |
Orientation:
|
plus strand |
|
Proteins
for SRCAP gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SRCAP_HUMAN, Q6ZRS2 (See
protein sequence)Recommended Name: Helicase SRCAP Size: 3230 amino acids; 343555 Da
Subunit: Interacts with CREBBP and EP300. May be part of a complex containing SRCAP, CREBBP, CARM1 and GRIP1. Componentof the chromatin-remodeling SRCAP complex composed of at least SRCAP, DMAP1, RUVBL1, RUVBL2, ACTL6A, YEATS4, VPS72,ACTR6 and ZNHIT1. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1,DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. Interacts with hepatitis C virus(HCV) NS5A and human adenovirus 2 DBP
Subcellular location: Nucleus
Sequence caution: Sequence=AAI59100.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B0JZA6 O15026 Q7Z744 Q9Y5L9Alternative splicing: 3 isoforms: Q6ZRS2-1 Q6ZRS2-2 Q6ZRS2-3 Explore the universe of human proteins at neXtProt for SRCAP: NX_Q6ZRS2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6ZRS2
4/12 DME Specific Peptides for SRCAP (Q6ZRS2) (see all 12)
SRCAP Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006653.2
ENSEMBL proteins: ENSP00000405186 ENSP00000262518 ENSP00000369719 ENSP00000378499 ENSP00000343042
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
SRCAP for ontologies About GeneDecksing
SRCAP Antibody Products:
Assay Products for SRCAP: |
Protein
Domains /
Families
for SRCAP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SRCAP for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q6ZRS2ProtoNet protein and cluster: Q6ZRS2 2 Blocks protein families: IPB000330 SNF2 related domain IPB006562 HSA
UniProtKB/Swiss-Prot: SRCAP_HUMAN, Q6ZRS2Similarity: Belongs to the SNF2/RAD54 helicase family. SWR1 subfamilySimilarity: Contains 3 A.T hook DNA-binding domainsSimilarity: Contains 1 helicase ATP-binding domainSimilarity: Contains 1 helicase C-terminal domainSimilarity: Contains 1 HSA domain |
Function
for SRCAP gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SRCAP_HUMAN, Q6ZRS2Function: Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimersfor nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as acoactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcriptionBiophysicochemical properties: Kinetic parameters: KM=66 uM for ATP;Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRCAP
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRCAP
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SRCAP (NM_006662) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SRCAP | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRCAP |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRCAP |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
SRCAP for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for SRCAP:
|
Pathways & Interactions
for SRCAP gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SRCAP
STRING Interaction
Network Preview (showing 5 interactants - click image to see 20)
5/22 Interacting proteins for SRCAP (Q6ZRS22, 3 ENSP000002625184) via UniProtKB, MINT, STRING, and/or I2D (see all 22)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
SRCAP for ontologies About GeneDecksing
|
Drugs & Compounds
for SRCAP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SRCAP
Search CenterWatch for drugs/clinical trials and news about SRCAP
|
Transcripts
for SRCAP gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SRCAP gene: NM_006662.2 Unigene Cluster for SRCAP: Snf2-related CREBBP activator protein Hs.647334 [show with all ESTs]Unigene Representative Sequence: NM_0066627 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000411466 ENST00000262518(uc002dze.1) ENST00000380361(uc002dzg.1 uc002dzf.3)
ENST00000483083 ENST00000474008 ENST00000395059(uc021tgn.1) ENST00000344771
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRCAP
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRCAP
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SRCAP (NM_006662) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SRCAP | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRCAP |
Additional cDNA sequence: AB621816.1 AF143946.1 AK023808.1 AK025382.1 AK128030.1 BC025284.1 BC063578.1 18 DOTS entries: DT.316808 DT.95293743 DT.95123715 DT.120714189 DT.95108207 DT.95117673 DT.70103663 DT.120714030 DT.99978807 DT.75159291 DT.92442126 DT.120714126 DT.120714229 DT.75198722 DT.95108206 DT.95148918 DT.102838761 DT.95328101 24/526 AceView cDNA sequences (see all 526): AA662809 BM543955 BM724438 AA588297 BM808047 BU176523 AA291854 BX644175 BQ051446 AA419088 BI520337 BX387296 BE739053 BM541884 BM700215 BU186404 BU145933 BU682683 H09771 BQ675195 BI858535 BX103840 AU140541 BQ219685
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SRCAP (see all 6) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 22a | · | 22b | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28a | · | 28b | ^ | 29a | · | 29b | ^ | 30 | ^ | 31a | · | 31b | ^ | 32 | ^ | 33 | ^ | 34 |
|---|
|
| SP1: | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SRCAP
|
Expression
for SRCAP gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SRCAP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAATGGGGA
About this image
See SRCAP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SRCAP
SOURCE GeneReport for Unigene cluster: Hs.647334
SABiosciences Custom PCR Arrays for SRCAP
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SRCAP
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SRCAP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRCAP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRCAP | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRCAP |
Orthologs
for SRCAP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SRCAP gene from 7/28 species (see all 28) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
SRCAP6 |
-- |
66(a) |
1 ↔ 1 |
GL343516.1(129011-143879) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.151092 |
Xenopus laevis transcribed sequence with weak similarity more |
76.85(n) |
|
CF284107.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
AL929039.16 |
-- |
33(a) |
1 ↔ 1 |
12(28635939-28661697) |
fruit fly
(Drosophila melanogaster) |
Insecta |
dom3 |
gene silencing helicase |
71(a) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
Y111B2A.233 |
-- |
53(a) |
|
III(12786231-12800283) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
PIE11 |
helicase SWR1 |
52.76(n)
48.52(a) |
|
820463 NM_112117.4 NP_187887.3 |
rice
(Oryza sativa) |
Liliopsida |
Os02g06898001 |
hypothetical protein |
53.67(n)
48(a) |
|
4330371 NM_001054321.1 NP_001047786.2 |
ENSEMBL Gene Tree for SRCAP (if available)
TreeFam Gene Tree for SRCAP (if available) |
Paralogs
for SRCAP gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SRCAP gene
- EP400NL2 EP4002
3 SIMAP similar genes for SRCAP using alignment to 4 protein entries: SRCAP_HUMAN (see all proteins):SMARCA5 HELLS ATRX
SRCAP for paralogs About GeneDecksing
|
Genomic Variants
for SRCAP gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SRCAP (30709530 - 30755602 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SRCAP
2 CNVs: 7103 2209
Human Gene Mutation Database (HGMD): SRCAP
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SRCAP |
|
Disorders
/ Diseases
for SRCAP gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SRCAP for disorders About GeneDecksing
OMIM gene information: 611421
OMIM disorders: --
UniProtKB/Swiss-Prot: SRCAP_HUMAN, Q6ZRS2
Defects in SRCAP are the cause of Floating-Harbor syndrome (FLHS) [MIM:136140]. A rare genetic disordercharacterized by proportionate short stature, delayed bone age, delayed speech development, and typical facialfeatures. The face is triangular with deep-set eyes, long eyelashes, bulbous nose, wide columella, short philtrum, andthin lips
8  diseases for SRCAP: About MalaCardsfloating-harbor syndrome rubinstein-taybi syndrome eaf short stature
hepatitis c hepatitis malaria prostatitis
1 disease from the University of Copenhagen DISEASES database for SRCAP:Rubinstein-Taybi syndrome Export disorders for SRCAP gene to outside databases
|
Publications
for SRCAP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SRCAP gene, integrated from 9 sources (see all 49):
(articles sorted by number of sources associating them with SRCAP) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a novel SNF2/SWI2 protein family member, SRCAP, which interacts with CREB-binding protein. (PubMed id 10347196)1, 2, 3, 9 Johnston H.... Chrivia J. (1999)
- Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2, 3 Nagase T.... Ohara O. (1997)
- SNF2-related CBP activator protein (SRCAP) functions as a coactivator of steroid receptor-mediated transcription through synergistic interactions with CARM-1 and GRIP-1. (PubMed id 14500758)1, 2, 9 Monroy M.A.... Chrivia J.C. (2003)
- Adenovirus DNA binding protein interacts with the SNF2-related CBP activator protein (SrCap) and inhibits SrCap-mediated transcription. (PubMed id 11581372)1, 2, 9 Xu X.... Yaciuk P. (2001)
- Mutations in SRCAP, encoding SNF2-related CREBBP activator protein, cause Floating-Harbor syndrome. (PubMed id 22265015)1, 2 Hood R.L.... Boycott K.M. (2012)
- The chromatin remodeling protein, SRCAP, is critical for deposition of the histone variant H2A.Z at promoters. (PubMed id 17617668)1, 2 Wong M.M.... Chrivia J.C. (2007)
- Purification of a human SRCAP complex that remodels chromatin by incorporating the histone variant H2A.Z into nucleosomes. (PubMed id 16634648)1, 2 Ruhl D.D.... Chrivia J.C. (2006)
- Human SRCAP and Drosophila melanogaster DOM are homologs that function in the notch signaling pathway. (PubMed id 16024792)1, 2 Eissenberg J.C.... Chrivia J.C. (2005)
- The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes. (PubMed id 15647280)1, 2 Cai Y.... Conaway J.W. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
|
External Searches for SRCAP gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SRCAP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SRCAP gene
(According to HUGE)
About This Section
| |
Specialized Databases showing SRCAP gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SRCAP | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SRCAP gene:
Search GeneIP for patents involving SRCAP
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SRCAP gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SRCAP | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SRCAP | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SRCAP | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SRCAP | | OriGene 3'-UTR Clone for SRCAP | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRCAP | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRCAP | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SRCAP | | OriGene Custom Protein Services for SRCAP | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SRCAP | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SRCAP | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRCAP | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRCAP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRCAP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRCAP |
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| | | | Search Tocris compounds for SRCAP |
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 | | | SRCAP Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRCAP |
|  |  |  | | | | Search ThermoFisher Antibodies for SRCAP |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRCAP |
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