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SRC Gene

protein-coding GIFtS: 72

GC20P035406

v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
(Previous name: v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: SRC1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ASV ^¹, ², ⁵
EC 2.7.10.2 ^³
OTTHUMP00000174476 ^²
OTTHUMP00000174477 ^²
SRC1 ^², ³, ⁵
c-SRC ^²
c-Src ^³
c-src ^¹
p60-Src ^², ³
pp60c-src ^³

Descriptions
proto-oncogene tyrosine-protein kinase SRC ^²
protooncogene SRC, Rous sarcoma ^²
tyrosine kinase pp60c-src ^²
tyrosine-protein kinase SRC-1 ^²
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog ^¹
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) ^²

External Ids
HGNC: 11283¹
Entrez Gene: 6714²
UniProtKB: P12931³
Ensembl: ENSG00000197122⁷

Search outside databases for aliases for SRC gene

Previous GC identifers: GC20P035740 GC20P036650 GC20P036696 GC20P036658

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for SRC:

This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a

role in the regulation of embryonic development and cell growth. The protein encoded by this gene

is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase.

Mutations in this gene could be involved in the malignant progression of colon cancer. Two

transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]

Gene Wiki entry for SRC (Src)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the SRC gene

Entrez Gene cytogenetic band: 20q12-q13 Ensembl cytogenetic band: 20q11.23 HGNC cytogenetic band: 20q12-q13

SRC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P035406: (about GC identifiers)

Start:	35,406,502 bp from pter
End:	35,467,867 bp from pter
Size:	61,366 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000020.9 NT_011362.9

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: SRC_HUMAN, P12931 (See protein sequence)

Recommended Name: Proto-oncogene tyrosine-protein kinase Src

Size: 536 amino acids; 59835 Da

Subunit: Interacts with DDEF1/ASAP1; via the SH3 domain. Interacts with CCPG1 (By similarity).

Interacts with CDCP1, PELP1, TGFB1I1 and TOM1L2. Interacts with the cytoplasmic domain of MUC1,

phosphorylates it and increases binding of MUC1 with beta-catenin. Interacts with RALGPS1; via the

SH3 domain. Interacts with HEV ORF3 protein; via the SH3 domain

PDB structures from and Proteopedia :

1A07 (3D)

1A08 (3D)

1A09 (3D)

1A1A (3D)

1A1B (3D)

1A1C (3D)

1A1E (3D)

1FMK (3D)

1HCS (3D)

1HCT (3D)

1KSW (3D)

1O41 (3D)

1O42 (3D)

1O43 (3D)

1O44 (3D)

1O45 (3D)

1O46 (3D)

1O47 (3D)

1O48 (3D)

1O49 (3D)

1O4A (3D)

1O4B (3D)

1O4C (3D)

1O4D (3D)

1O4E (3D)

1O4F (3D)

1O4G (3D)

1O4H (3D)

1O4I (3D)

1O4J (3D)

1O4K (3D)

1O4L (3D)

1O4M (3D)

1O4N (3D)

1O4O (3D)

1O4P (3D)

1O4Q (3D)

1O4R (3D)

1SHD (3D)

1Y57 (3D)

1YI6 (3D)

1YOJ (3D)

1YOL (3D)

1YOM (3D)

2BDF (3D)

2BDJ (3D)

2H8H (3D)

2SRC (3D)

Secondary accessions: Q86VB9 Q9H5A8

Alternative splicing: 2 isoforms: P12931-1 P12931-2

Post-translational modifications:

Phosphorylated on Tyr-530 by c-Src kinase (CSK). The phosphorylated form is termed pp60c-src. The

phosphorylated tail interacts with the SH2 domain thereby repressing kinase activity¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_005408.1 NP_938033.1

ENSEMBL proteins:

ENSP00000353950 ENSP00000362668 ENSP00000362659 ENSP00000362680 ENSP00000350941

Human Recombinant Proteins

	Invitrogen human recombinant proteins for SRC
	Millipore Purified and/or Recombinant SRC Protein
	Sigma-Aldrich Proteins for SRC
	R&D Systems Recombinant & Natural Proteins for SRC
	Enzo Life Sciences proteins for SRC
	Recombinant Proteins from Abcam (Src, SRC Family Negative Regulatory Phosphorylation Site)
	Human Recombinant Proteins from Abnova (SRC)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	EXP	10858437 11124251
GO:0005886	plasma membrane	IEA	--
GO:0005901	caveola	IDA	17848177

About this table

Antibodies for SRC:

	Invitrogen Antibodies for SRC
	Millipore Mono- and Polyclonal Antibodies for the study of SRC
	Sigma-Aldrich Antibodies for SRC
	R&D Systems Antibodies for SRC
	Cell Signaling Technology (CST) Antibodies for SRC
	Antibodies from Abcam (Src, SRC Family Negative Regulatory Phosphorylation Site), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (SRC)
	Novus Biologicals Antibodies for SRC

Assays for SRC:

	Invitrogen Assays for SRC
	Millipore Kits and Assays for the Analysis of SRC
	R&D Systems ELISAs for SRC (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P12931

ProtoNet protein and cluster: P12931

3 Blocks protein families:

IPB000980 SH2 domain signature

IPB001452 SH3 domain signature

IPB008266 Tyrosine protein kinase

UniProtKB/Swiss-Prot: SRC_HUMAN, P12931

Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily

Similarity: Contains 1 protein kinase domain

Similarity: Contains 1 SH2 domain

Similarity: Contains 1 SH3 domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SRC)
		Millipore RNAi Products for the Analysis of SRC Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (SRC)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_198291

Applied Biosystems Silencer® siRNAs for SRC

Sigma-Aldrich siRNA and siRNA Panels for SRC

Sigma-Aldrich shRNA Panels and shRNA for SRC

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for SRC
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_005417
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_005417
untagged cDNA clones in CMV expression vector (see all 3): NM_005417

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005417

UniProtKB/Swiss-Prot: SRC_HUMAN, P12931

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

Enzyme Number (IUBMB): EC 2.7.10.2

Genatlas biochemistry entry for SRC:

avian sarcoma (Schmidt-Ruppin A-2) viral (v-src) oncogene homolog

15/16 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Src) (see all 16 ):

behavior/neurological	craniofacial	growth/size	hematopoietic system	immune system
lethality-postnatal	lethality-prenatal/perinatal	life span-post-weaning/aging	limbs/digits/tail	nervous system
pigmentation	reproductive system	respiratory system	skeleton	skin/coat/nails

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004715	non-membrane spanning protein tyrosine kinase activity	IEA	--
GO:0005070	SH3/SH2 adaptor activity	TAS	9020193
GO:0005524	ATP binding	IEA	--
GO:0008022	protein C-terminus binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/34 Sigma-Aldrich "Your Favorite Gene" Pathways for SRC (Your Favorite Gene powered by Ingenuity) (see all 34 )

14-3-3-mediated Signaling
Integrin Signaling
RAR Activation
Neuregulin Signaling
Wnt/&beta

GeneDecks SRC for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for SRC

5/643 Interacting proteins for SRC (P12931^{1, 2} ENSP00000362659³) via UniProtKB, MINT, and/or STRING (see all 643 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PTPN1	P18031², ENSP00000360683³	MINT-6797096 MINT-6793501 MINT-6794959 MINT-6795286 MINT-6794163 MINT-6795447 MINT-6764626 MINT-6764915 MINT-6795268 MINT-6795409 MINT-6795229 MINT-6794843 MINT-6794810 MINT-6795255 STRING (score=.999)
CBL	P22681², ENSP00000264033³	MINT-7040192 MINT-7040213 MINT-7040318 MINT-3982451 MINT-6539730 MINT-7040120 MINT-7040304 STRING (score=.999)
MLLT4	P55196², ENSP00000252692³	MINT-4950584 MINT-4961227 MINT-4961303 MINT-4961273 MINT-4961253 MINT-4961196 MINT-4961138 STRING (score=.981)
RPL10P16	P27635², ENSP00000358825³	MINT-7145938 MINT-7145955 MINT-7145972 MINT-7146023 MINT-7145921 MINT-7145994 STRING (score=.96)
LNX1	Q8TBB1², ENSP00000263925³	MINT-6538383 MINT-6504442 MINT-6504455 MINT-6504479 MINT-6504523 MINT-6504500 STRING (score=.939)

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5/19 Gene Ontology (GO) biological process terms (links to tree view) (see all 19 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001101	response to acid	IEA	--
GO:0006950	response to stress	IEA	--
GO:0007172	signal complex assembly	TAS	9924018
GO:0007173	epidermal growth factor receptor signaling pathway	IEA	--
GO:0007243	protein kinase cascade	TAS	9020193

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for SRC

Sigma-Aldrich Small Molecules for SRC:

Antagonist Inhibitor

Compounds for SRC available from Tocris Bioscience

Compound	Action	CAS number
Herbimycin A	Src family kinase inhibitor. Also Hsp90 inhibitor	[70563-58-5]
Lavendustin A	EGFR, p60c-src inhibitor	[125697-92-9]
1-Naphthyl PP1	Src family kinase inhibitor; also inhibits c-Abl	[221243-82-9]
MNS	Selective inhibitor of Src and Syk	[1485-00-3]

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10/26 Novoseek chemical compound relationships for SRC gene (see all 26 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	94.69	2639	9096689 (6), 11641791 (6), 9331427 (5), 12869565 (5) (see all 99)
phosphotyrosine	87.72	146	9337879 (2), 10880360 (2), 16611216 (2), 11493667 (2) (see all 99)
4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine	84.06	15	15618223 (1), 16669788 (1), 19145781 (1), 12739161 (1) (see all 12)
phosphatidylinositol	80.79	178	1332046 (2), 9565618 (2), 11230874 (2), 7538175 (2) (see all 99)
cgp77675	75.47	7	11840778 (1), 14521054 (1), 10833396 (1), 15087474 (1) (see all 6)
phosphoinositide	65.53	55	1311317 (3), 15817454 (2), 15556934 (2), 10880360 (1) (see all 42)
wortmannin	63.09	24	17299794 (2), 10393094 (1), 11069718 (1), 11267999 (1) (see all 18)
pd173955	62.78	1	10373450 (1)
pd 98,059	60.90	16	14570928 (1), 17526768 (1), 10779380 (1), 12925710 (1) (see all 14)
threonine	59.82	36	7516061 (3), 1379736 (2), 7690037 (2), 12378693 (2) (see all 26)

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2 PharmGKB drug compound relationships for SRC gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Beta adrenergic antagonists	FA	14499340
isoproterenol	FA	14990578 9363896

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SRC)
		Millipore RNAi Products for the Analysis of SRC Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (SRC)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_198291

Sigma-Aldrich siRNA and siRNA Panels for SRC

Sigma-Aldrich shRNA Panels and shRNA for SRC

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005417 NM_198291

REFSEQ mRNAs for SRC gene (2 alternative transcripts):

NM_005417.3 NM_198291.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005417 NM_198291

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_005417
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_005417
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_005417

Additional cDNA sequence:

AF272982.1 AK024281.1 BC011566.1 BC051270.1 Z18364.1

11 DOTS entries:

DT.310679 DT.95082049 DT.75101398 DT.100820136 DT.95118917 DT.91929476 DT.95082051 DT.120827952

DT.120827971 DT.75180400 DT.95358075

24/131 AceView cDNA sequences (see all 131 ):

CD365254 NM_198291 BC011566 AW298220 BM761470 CD369263 AK024281 CA502880

NM_005417 CD364525 AI282193 BE391008 BM352972 AW135290 BC051270 BQ941942

BE467452 CK821940 BF685697 BE388654 BE732984 BE504806 CD742807 BQ924865

highest scoring ESTs for SRC:

AA398992 AA399627 AA402622 AA729487 AA999869 AI536788 AI564897 AK024281 AW275187 AW364235

Unigene Cluster for SRC:

V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)

Hs.195659 [show with all ESTs]

Unigene Representative Sequence: NM_005417

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SRC (see all 8 )

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	^	8	^	9	^	10a	·	10b	^	11a	·	11b	^	12a	·	12b	^	13a	·	13b	^	14a	·	14b	^	15
SP1:					-										-										-												-		-						-
SP2:															-										-												-		-						-
SP3:																																					-		-						-
SP4:																									-
SP5:					-

About this scheme

ECgene alternative splicing isoforms for SRC

5 Ensembl transcripts including schematic representations:

ENST00000360723 ENST00000373567 ENST00000373558 ENST00000373578 ENST00000358208

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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SRC expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for SRC

¹ / ² / ³

9 probe-sets matching SRC gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38904_at²^{, 3}	U95-A	1	1.00	1.00	0.78	0.75	AF077754	0.20	1.00	0.72	1
1938_at²^{, 3}	U95-A	1	1.00	1.00	0.60	1.26	K03218	0.20	1.00	0.72	1
213324_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AK024281	0.80	1.00	0.91	1
221284_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005417	0.60	1.00	0.82	1
1565082_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
213324_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1565080_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
221284_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1558211_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.195659
Expression variation in blood from EXPOLDB for SRC

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SRC gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	SRC¹	--	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog more	92.41(n) 98.88(a)	485864 XM_542988.2 XP_542988.2
chimpanzee (Pan troglodytes)	SRC¹	--	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog more	94.22(n) 92.54(a)	458229 XM_001141228.1 XP_001141228.1
cow (Bos taurus)	SRC¹	--	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog more	92.79(n) 98.13(a)	535742 XM_615852.3 XP_615852.2
rat (Rattus norvegicus)	Src¹	--	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog more	89.91(n) 99.25(a)	83805 NM_031977.1 NP_114183.1
mouse (Mus musculus)	Src^{1, 5}	2 (89.00 cM)⁵	Rous sarcoma oncogene^{1, 5}	90.09(n)¹ 99.07(a)¹	20779¹ NM_009271.3¹ NP_033297.2¹ AJ312258⁵ AJ312259⁵ (see all 28)

About this table Species with no ortholog for SRC

ENSEMBL Gene Tree for SRC

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for SRC gene

FYN² FGR² YES1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/383 NCBI SNPs in SRC are shown (see all 383 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 129)

AB	SNP ID	Valid	Chr 20 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs6017916^1,2	A,C,F,H	35404692(+)	`GCTTCA/CACTAG`	1	--	ng5¹		8	EU EA WA NA	774
--	rs3762203^1,2	A,C,F,H	35444443(-)	`tcagcG/Atcctc`	2	--	ut5¹ ese³		4	EU EA WA	412
--	rs6011987^1,2	A,C,F,H	35405701(+)	`GGGGTG/AGTTAA`	1	--	ng5¹ tfbs³		3	EU EA	300
--	rs7275012^1,2	A,C,F	35406513(+)	`AGTGCG/AGCCAT`	2	--	ut5¹ ng5¹ ese³		3	NA	142
	rs6017919^1,2	A,F,H	35405348(+)	`ccctcG/Atttta`	1	--	ng5¹		4	EU EA WA	412
--	rs17785475^1,2	C,F	35466307(+)	`TGTCCC/TGTGGC`	2	--	ut3¹ ese³		3	NA	138
	rs6017917^1,2	C,F	35405160(+)	`TATATA/GCAGTT`	1	--	ng5¹ tfbs³		3	NA	142
	rs7273386^1,2	F,H	35406196(+)	`GGCTTG/CATTGG`	2	--	ng5¹		1	EU	106
	rs6094386^1,2	H	35407406(+)	`ACTCAG/AGTCAA`	2	--	int¹ ng5¹		4	EU EA WA	394
	rs6124957^1,2	H	35465551(+)	`GCTCAC/TTGAAC`	2	--	ut3¹ ese³		4	EU EA WA	410

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HapMap Linkage Disequilibrium images for SRC (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 190090

10/92 Novoseek disease relationships for SRC gene (see all 92 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
sarcoma rous	57.17	35	7609076 (3), 7853507 (2), 14969582 (1), 16211495 (1) (see all 21)
tumors	56.72	340	10022129 (5), 10473101 (5), 18556171 (4), 16951177 (4) (see all 99)
cancer	56.07	225	19307596 (5), 14760089 (4), 15060621 (4), 11114744 (4) (see all 99)
breast cancer	55.69	214	19383905 (5), 9014858 (5), 11007774 (4), 19372587 (4) (see all 99)
wiskott-aldrich syndrome	53.64	8	8824280 (3), 8892607 (1), 15673667 (1), 16741966 (1) (see all 6)
colon cancer	52.55	97	17934522 (5), 9444956 (4), 12939401 (4), 18839319 (4) (see all 45)
metastasis	45.96	127	7687314 (6), 19383905 (4), 15753384 (4), 9142389 (3) (see all 66)
x-linked agammaglobulinemia	45.83	2	7519238 (1), 7880320 (1)
cancer invasiveness	42.22	1	19383905 (1)
prostate cancer	40.45	53	16894533 (4), 18679417 (4), 16140968 (4), 17426060 (4) (see all 27)

About this table

3 PharmGKB disease relationships for SRC gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Asthma	FA	12003786
Heart Failure, Congestive	FA	14499340
Hypertension	FA	14499340

About this table

Human Gene Mutation Database: SRC
Tumor Gene Database: SRC
Breast Cancer Gene Database: SRC

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/2561 PubMed articles for SRC gene (see all 2561 ):

Human cellular src gene: nucleotide sequence and derived amino acid sequence of the region coding for the carboxy-terminal two-thirds of pp60c-src. (PubMed id 2582238)^{2, 3, 4} Anderson S.K.... Fujita D.J. (1985)
The c-Src tyrosine kinase regulates signaling of the human DF3/MUC1 carcinoma-associated antigen with GSK3 beta and beta-catenin. (PubMed id 11152665)^{1, 3, 4} Li Y....Kufe D. (2001)
Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. (PubMed id 17192257)^{3, 4} Wissing J.... Daub H. (2007)
The adaptor protein Tom1L1 is a negative regulator of Src mitogenic signaling induced by growth factors. (PubMed id 16479011)^{3, 4} Franco M.... Roche S. (2006)
The C2 domain of PKCdelta is a phosphotyrosine binding domain. (PubMed id 15851033)^{3, 4} Benes C.H.... Soltoff S.P. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade. (PubMed id 12415108)^{3, 4} Wong C.-W.... Cheskis B.J. (2002)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{3, 4} Deloukas P....Rogers J. (2001)
Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study. (PubMed id 9174343)^{3, 4} Charifson P.S....Consler T.G. (1997)
Three-dimensional structure of the tyrosine kinase c-Src. (PubMed id 9024657)^{3, 4} Xu W.... Eck M.J. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 6714	HGNC: 11283	AceView: SRC	Ensembl:ENSG00000197122	euGenes: HUgn6714
ECgene: SRC	H-InvDB: SRC

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for SRC	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for SRC
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for SRC:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for SRC-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for SRC		Antibodies for SRC
	Explore super-pooled esiRNAs		Proteins for SRC
	Lentivirus-delivered shRNAs for SRC		Small molecules for SRC
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (SRC)
	Antibodies (SRC)
	Chimera RNAi (SRC)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for SRC

	Recombinant Proteins (Src, SRC Family Negative Regulatory Phosphorylation Site)
	Antibodies (Src, SRC Family Negative Regulatory Phosphorylation Site)

Search OriGene for SRC

Tocris compounds for SRC

	Drugs/Proteins for SRC
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for SRC

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SRC Gene

protein-coding GIFtS: 72

Aliases &
Descriptions
for SRC

Summaries
for SRC

Genomic Location
for SRC

Proteins
for SRC

Protein Domains/
Families
for SRC

Gene Function
for SRC

Pathways & Interactions
for SRC

Drugs & Compounds
for SRC

Transcripts
for SRC

Expression
for SRC

Orthologs
for SRC

Paralogs
for SRC

SNPs/Variants
for SRC

Disorders & Mutations
for SRC

Medical News
for SRC

Publications
for SRC

Search for SRC

Genome Databases showing SRC

Other Databases showing SRC

Specialized Databases showing SRC

Licensable Technologies
for SRC

Services
for SRC

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

SRC Gene

protein-coding GIFtS: 72

Aliases & Descriptionsfor SRC

Summariesfor SRC

Genomic Locationfor SRC

Proteinsfor SRC

Protein Domains/Familiesfor SRC

Gene Functionfor SRC

Pathways & Interactionsfor SRC

Drugs & Compoundsfor SRC

Transcriptsfor SRC

Expression for SRC

Orthologsfor SRC

Paralogsfor SRC

SNPs/Variantsfor SRC

Disorders & Mutationsfor SRC

Medical Newsfor SRC

Publicationsfor SRC

Search for SRC

Genome Databases showing SRC

Other Databases showing SRC

Specialized Databases showing SRC

Licensable Technologiesfor SRC

Servicesfor SRC

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for SRC

Summaries
for SRC

Genomic Location
for SRC

Proteins
for SRC

Protein Domains/
Families
for SRC

Gene Function
for SRC

Pathways & Interactions
for SRC

Drugs & Compounds
for SRC

Transcripts
for SRC

Expression
for SRC

Orthologs
for SRC

Paralogs
for SRC

SNPs/Variants
for SRC

Disorders & Mutations
for SRC

Medical News
for SRC

Publications
for SRC

Licensable Technologies
for SRC

Services
for SRC