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Aliases for SRC Gene

Aliases for SRC Gene

  • SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase 2 3
  • SRC1 3 4 6
  • V-Src Avian Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog 2 3
  • Proto-Oncogene C-Src 3 4
  • EC 2.7.10.2 4 63
  • P60-Src 3 4
  • ASV 3 6
  • Proto-Oncogene Tyrosine-Protein Kinase Src 3
  • Protooncogene SRC, Rous Sarcoma 3
  • Tyrosine-Protein Kinase SRC-1 3
  • Tyrosine Kinase Pp60c-Src 3
  • Pp60c-Src 4
  • EC 2.7.10 63
  • C-SRC 3

External Ids for SRC Gene

Previous HGNC Symbols for SRC Gene

  • SRC1

Previous GeneCards Identifiers for SRC Gene

  • GC20P035740
  • GC20P036650
  • GC20P036696
  • GC20P036658
  • GC20P035406
  • GC20P035973
  • GC20P032708

Summaries for SRC Gene

Entrez Gene Summary for SRC Gene

  • This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SRC Gene

SRC (SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with SRC include estrogen-receptor negative breast cancer and differentiating neuroblastoma. Among its related pathways are PI-3K cascade and PI-3K cascade. GO annotations related to this gene include identical protein binding and protein kinase activity. An important paralog of this gene is ABL2.

UniProtKB/Swiss-Prot for SRC Gene

  • Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1. Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors. Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1. Plays a role in EGF-mediated calcium-activated chloride channel activation. Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at Tyr-1477. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of ADRBK1, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor. Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus. Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase. Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation. Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on Tyr-284 and CBL on Tyr-731. Enhances DDX58/RIG-I-elicited antiviral signaling. Phosphorylates PDPK1 at Tyr-9, Tyr-373 and Tyr-376. Phosphorylates BCAR1 at Tyr-128. Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at Tyr-341 activates CBLC E3 activity.

Tocris Summary for SRC Gene

  • Src kinases consist of eight non-receptor tyrosine kinases (Src, Fyn, Yes, Lck, Lyn, Hck, Fgr and Blk) that interact with the intracellular domains of growth factor/cytokine receptors, GPCRs and integrins. Members of the Src kinase family have a very similar domain structure with a high degree of homology in the SH1 (catalytic), linker, SH2 (p-Tyr binding), SH3 (protein-protein interaction) and SH4 (membrane association) domains. c-Src, Fyn and Yes are ubiquitously expressed, although high levels of c-Src are found in platelets, neural tissue and osteoclasts. For c-Src, autophosphorylation of Tyr418 and dephosphorylation of Tyr530 is required to switch the kinase from the inactive closed formation to the active open formation. c-Src can be inactivated by two kinases, c-Src kinase (CSK) and CSK homologous kinase (CHK), both of which phosphorylate Tyr530 of c-Src. The activity of the Src kinase family can also be regulated by phosphatases (e.g. SHP1), binding to adaptor proteins (e.g. Cbp) and proteasomal degradation. Src kinases are key upstream mediators of both the PI 3-K and MAPK signaling pathways, and have been shown to have important roles in cell proliferation, migration and survival.

Gene Wiki entry for SRC Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRC Gene

Genomics for SRC Gene

Regulatory Elements for SRC Gene

Transcription factor binding sites by QIAGEN in the SRC gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SRC Gene

Start:
37,344,685 bp from pter
End:
37,406,050 bp from pter
Size:
61,366 bases
Orientation:
Plus strand

Genomic View for SRC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SRC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRC Gene

Proteins for SRC Gene

  • Protein details for SRC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12931-SRC_HUMAN
    Recommended name:
    Proto-oncogene tyrosine-protein kinase Src
    Protein Accession:
    P12931
    Secondary Accessions:
    • E1P5V4
    • Q76P87
    • Q86VB9
    • Q9H5A8

    Protein attributes for SRC Gene

    Size:
    536 amino acids
    Molecular mass:
    59835 Da
    Quaternary structure:
    • Interacts with DDEF1/ASAP1; via the SH3 domain. Interacts with CCPG1. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts with ERBB2, STAT1 and PNN. Interacts with DDR1, DDR2 and DAB2. Interacts with CDCP1, PELP1, TGFB1I1 and TOM1L2. Interacts with the cytoplasmic domain of MUC1, phosphorylates it and increases binding of MUC1 with beta-catenin. Interacts with RALGPS1; via the SH3 domain. Interacts with HEV ORF3 protein; via the SH3 domain. Interacts with CAV2 (tyrosine phosphorylated form). Interacts (via the SH3 domain and the protein kinase domain) with ARRB1; the interaction is independent of the phosphorylation state of SRC C-terminus. Interacts with ARRB1 and ARRB2. Interacts with SRCIN1. Interacts with NDFIP2 and more weakly with NDFIP1. Interacts with PIK3CA and/or PIK3C2B, PTK2/FAK1 and ESR1 (dimethylated on arginine). Interacts with FASLG. Interacts (via SH2 domain) with the Tyr-402 phosphorylated form of PTK2B/PYK2. Interacts (via SH2 domain) with FLT3 (tyrosine phosphorylated). Interacts with PDGFRA (tyrosine phosphorylated). Interacts with CSF1R. Interacts (via SH2 and SH3 domain) with TNK2. Interacts (via protein kinase domain) with the tyrosine phosphorylated form of RUNX3 (via runt domain). Interacts with TRAF3 (via RING-type zinc finger domain). Interacts with DDX58, MAVS and TBK1. Interacts (via SH2 domain) with GNB2L1/RACK1; the interaction is enhanced by tyrosine phosphorylation of GNB2L1 and inhibits SRC activity. Interacts with EPHB1; activates the MAPK/ERK cascade to regulate cell migration. Interacts with FCAMR. Interacts (via SH2 domain) with the Tyr-9 phosphorylated form of PDPK1. Interacts with AMOTL2; this interaction regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Interacts with TRAP1. Interacts with CBLC; the interaction is enhanced when SRC is phosphorylated at Tyr-419.

    Three dimensional structures from OCA and Proteopedia for SRC Gene

    Alternative splice isoforms for SRC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRC Gene

Proteomics data for SRC Gene at MOPED

Post-translational modifications for SRC Gene

  • Dephosphorylated at Tyr-530 by PTPRJ (By similarity). Phosphorylated on Tyr-530 by c-Src kinase (CSK). The phosphorylated form is termed pp60c-src. Dephosphorylated by PTPRJ at Tyr-419. Normally maintained in an inactive conformation with the SH2 domain engaged with Tyr-530, the SH3 domain engaged with the SH2-kinase linker, and Tyr-419 dephosphorylated. Dephosphorylation of Tyr-530 as a result of protein tyrosine phosphatase (PTP) action disrupts the intramolecular interaction between the SH2 domain and Tyr-530, Tyr-419 can then become autophosphorylated, resulting in SRC activation. Phosphorylation of Tyr-530 by CSK allows this interaction to reform, resulting in SRC inactivation. CDK5-mediated phosphorylation at Ser-75 targets SRC to ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. Phosphorylated by PTK2/FAK1; this enhances kinase activity. Phosphorylated by PTK2B/PYK2; this enhances kinase activity.
  • Myristoylated at Gly-2, and this is essential for targeting to membranes.
  • S-nitrosylation is important for activation of its kinase activity.
  • Ubiquitinated in response to CDK5-mediated phosphorylation. Ubiquitination mediated by CBLC requires SRC autophosphorylation at Tyr-419 and may lead to lysosomal degradation.
  • Ubiquitination at Lys430
  • Modification sites at PhosphoSitePlus

Other Protein References for SRC Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SRC (Src)

Protein Products

Assay Products

  • antibodies-online kits for SRC

Domains for SRC Gene

Gene Families for SRC Gene

Suggested Antigen Peptide Sequences for SRC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P12931

UniProtKB/Swiss-Prot:

SRC_HUMAN :
  • P12931
Domain:
  • The SH2 and SH3 domains are important for the intramolecular and intermolecular interactions that regulate catalytic activity, localization, and substrate recruitment
  • Contains 1 protein kinase domain.
  • Contains 1 SH2 domain.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
genes like me logo Genes that share domains with SRC: view

Function for SRC Gene

Molecular function for SRC Gene

GENATLAS Biochemistry: avian sarcoma (Schmidt-Ruppin A-2) viral (v-src) oncogene homolog
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation: Phosphorylation by CSK at Tyr-530 inhibits kinase activity. Inhibitory phosphorylation at Tyr-530 is enhanced by heme. Further phosphorylation by CDK1 partially reactivates CSK-inactivated SRC and facilitates complete reactivation by protein tyrosine phosphatase PTPRC. Integrin engagement stimulates kinase activity. Phosphorylation by PTK2/FAK1 enhances kinase activity. Butein and pseudosubstrate-based peptide inhibitors like CIYKYYF act as inhibitors. Phosphorylation at Tyr-419 increases kinase activity.
UniProtKB/Swiss-Prot Function: Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1. Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors. Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1. Plays a role in EGF-mediated calcium-activated chloride channel activation. Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at Tyr-1477. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of ADRBK1, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor. Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus. Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase. Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation. Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on Tyr-284 and CBL on Tyr-731. Enhances DDX58/RIG-I-elicited antiviral signaling. Phosphorylates PDPK1 at Tyr-9, Tyr-373 and Tyr-376. Phosphorylates BCAR1 at Tyr-128. Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at Tyr-341 activates CBLC E3 activity.

Enzyme Numbers (IUBMB) for SRC Gene

Gene Ontology (GO) - Molecular Function for SRC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS --
GO:0004713 protein tyrosine kinase activity TAS --
GO:0004715 non-membrane spanning protein tyrosine kinase activity TAS 19267251
GO:0005070 SH3/SH2 adaptor activity TAS 9020193
GO:0005080 protein kinase C binding IEA --
genes like me logo Genes that share ontologies with SRC: view
genes like me logo Genes that share phenotypes with SRC: view

Animal Models for SRC Gene

MGI Knock Outs for SRC:

Animal Model Products

CRISPR Products

miRNA for SRC Gene

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for SRC Gene

Localization for SRC Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRC Gene

Cell membrane. Mitochondrion inner membrane. Nucleus. Cytoplasm, cytoskeleton. Note=Localizes to focal adhesion sites following integrin engagement. Localization to focal adhesion sites requires myristoylation and the SH3 domain.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRC Gene COMPARTMENTS Subcellular localization image for SRC gene
Compartment Confidence
cytoskeleton 5
endosome 5
lysosome 5
mitochondrion 5
nucleus 5
plasma membrane 5
vacuole 5
cytosol 4
extracellular 3
endoplasmic reticulum 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for SRC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IDA 19767770
GO:0005743 mitochondrial inner membrane IDA 12615910
GO:0005764 lysosome IDA 20605918
genes like me logo Genes that share ontologies with SRC: view

Pathways for SRC Gene

genes like me logo Genes that share pathways with SRC: view

PCR Array Products

Gene Ontology (GO) - Biological Process for SRC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0006468 protein phosphorylation --
GO:0007049 cell cycle IEA --
GO:0007155 cell adhesion IBA --
GO:0007165 signal transduction TAS 10734107
genes like me logo Genes that share ontologies with SRC: view

Compounds for SRC Gene

(5) Tocris Compounds for SRC Gene

Compound Action Cas Number
1-Naphthyl PP1 Src family kinase inhibitor; also inhibits c-Abl [221243-82-9]
KB SRC 4 Potent and selective c-Src inhibitor [1380088-03-8]
PP 2 Potent, selective Src family kinase inhibitor [172889-27-9]
PP 3 Negative control for PP 2 (Cat. No. 1407) [5334-30-5]
Src I1 Dual site Src kinase inhibitor [179248-59-0]

(2) HMDB Compounds for SRC Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(125) Novoseek inferred chemical compound relationships for SRC Gene

Compound -log(P) Hits PubMed IDs
tyrosine 94.7 303
phosphotyrosine 87.5 113
4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine 84.2 14
dasatinib 80.8 60
phosphatidylinositol 80.5 110
genes like me logo Genes that share compounds with SRC: view

Transcripts for SRC Gene

Unigene Clusters for SRC Gene

V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian):
Representative Sequences:

CRISPR Products

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRC Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15
SP1: - - - - - -
SP2: - - - - -
SP3: - - -
SP4: -
SP5: -
SP6: -
SP7:
SP8:

Relevant External Links for SRC Gene

GeneLoc Exon Structure for
SRC
ECgene alternative splicing isoforms for
SRC

Expression for SRC Gene

mRNA expression in normal human tissues for SRC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SRC Gene

SOURCE GeneReport for Unigene cluster for SRC Gene Hs.195659

mRNA Expression by UniProt/SwissProt for SRC Gene

P12931-SRC_HUMAN
Tissue specificity: Expressed ubiquitously. Platelets, neurons and osteoclasts express 5-fold to 200-fold higher levels than most other tissues
genes like me logo Genes that share expressions with SRC: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SRC Gene

Orthologs for SRC Gene

This gene was present in the common ancestor of animals.

Orthologs for SRC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRC 35
  • 99.69 (n)
  • 100 (a)
SRC 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SRC 35
  • 92.79 (n)
  • 98.13 (a)
SRC 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRC 35
  • 92.41 (n)
  • 98.88 (a)
SRC 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Src 35
  • 90.09 (n)
  • 99.07 (a)
Src 16
Src 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SRC 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Src 35
  • 89.91 (n)
  • 99.25 (a)
chicken
(Gallus gallus)
Aves SRC 35
  • 85.8 (n)
  • 94.75 (a)
SRC 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRC 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia src 35
  • 76.63 (n)
  • 89.1 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8231 35
zebrafish
(Danio rerio)
Actinopterygii src 35
  • 76.06 (n)
  • 84.69 (a)
src 36
  • 83 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006510 35
  • 59.32 (n)
  • 54.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta Src64B 35
  • 57.91 (n)
  • 52.98 (a)
Species with no ortholog for SRC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SRC Gene

ENSEMBL:
Gene Tree for SRC (if available)
TreeFam:
Gene Tree for SRC (if available)

Paralogs for SRC Gene

Paralogs for SRC Gene

genes like me logo Genes that share paralogs with SRC: view

Variants for SRC Gene

Sequence variations from dbSNP and Humsavar for SRC Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs744285 -- 37,382,072(+) TTGCC(C/T)GAGGA intron-variant
rs747182 -- 37,354,486(+) TCAAT(C/T)TTCTC intron-variant
rs754625 -- 37,389,121(-) ATCCA(C/T)GGCGC intron-variant
rs754626 -- 37,388,937(-) ACAGT(A/C)ATAGG intron-variant
rs911496 -- 37,382,454(+) AGACT(G/T)TGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRC Gene

Variant ID Type Subtype PubMed ID
nsv524059 CNV Loss 19592680
nsv509767 CNV Insertion 20534489
nsv470551 CNV Gain 18288195
nsv458967 CNV Loss 19166990
nsv523618 CNV Loss 19592680
esv2722386 CNV Deletion 23290073
esv2722387 CNV Deletion 23290073
esv2722388 CNV Deletion 23290073
nsv833968 CNV Gain 17160897
dgv510n27 CNV Loss 19166990
nsv528371 CNV Loss 19592680
nsv523834 CNV Gain 19592680
nsv516343 CNV Gain+Loss 19592680

Relevant External Links for SRC Gene

HapMap Linkage Disequilibrium report
SRC
Human Gene Mutation Database (HGMD)
SRC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRC Gene

Disorders for SRC Gene

UniProtKB/Swiss-Prot

SRC_HUMAN
  • Note=SRC kinase activity has been shown to be increased in several tumor tissues and tumor cell lines such as colon carcinoma cells.

(91) Novoseek inferred disease relationships for SRC Gene

Disease -log(P) Hits PubMed IDs
cancer 59.8 151
breast cancer 59 177
tumors 58.8 182
sarcoma rous 56.1 24
wiskott-aldrich syndrome 53 8

Relevant External Links for SRC

Genetic Association Database (GAD)
SRC
Human Genome Epidemiology (HuGE) Navigator
SRC
Tumor Gene Database (TGDB):
SRC
genes like me logo Genes that share disorders with SRC: view

Publications for SRC Gene

  1. RACK1, a receptor for activated C kinase and a homolog of the beta subunit of G proteins, inhibits activity of src tyrosine kinases and growth of NIH 3T3 cells. (PMID: 9584165) Chang B.Y. … Cartwright C.A. (Mol. Cell. Biol. 1998) 3 4 23
  2. EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis. (PMID: 12925710) Vindis C. … Huynh-Do U. (J. Cell Biol. 2003) 3 4 23
  3. Tyrosine 740 phosphorylation of discoidin domain receptor 2 by Src stimulates intramolecular autophosphorylation and Shc signaling complex formation. (PMID: 16186108) Yang K. … Yang B.S. (J. Biol. Chem. 2005) 3 4 23
  4. Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm. (PMID: 20100835) Goh Y.M. … Bae S.C. (J. Biol. Chem. 2010) 3 4 23
  5. Human cellular src gene: nucleotide sequence and derived amino acid sequence of the region coding for the carboxy-terminal two-thirds of pp60c-src. (PMID: 2582238) Anderson S.K. … Fujita D.J. (Mol. Cell. Biol. 1985) 2 3 4

Products for SRC Gene

  • Addgene plasmids for SRC

Sources for SRC Gene

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