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SRC Gene

protein-coding   GIFtS: 77
GCID: GC20P035973

V-Src Avian Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene...


(Previous symbol: SRC1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 4.2

Aliases
V-Src Avian Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog1 2     Proto-Oncogene Tyrosine-Protein Kinase Src2
SRC11 2 3 5     Protooncogene SRC, Rous Sarcoma2
Proto-Oncogene C-Src2 3     Tyrosine Kinase Pp60c-Src2
p60-Src2 3     Tyrosine-Protein Kinase SRC-12
EC 2.7.10.23 8     pp60c-src3
ASV2 5     EC 2.7.108
c-SRC2     

External Ids:    HGNC: 112831   Entrez Gene: 67142   Ensembl: ENSG000001971227   OMIM: 1900905   UniProtKB: P129313   
ORGUL members:    fRNAdb10:FR349626 FR089456      
H-InvDB12:HIT000326568    
NCBI13:Z18364    
NONCODE14:n339669 n336581    
RNAdb15:HIV2756 RNZ21376    

Export aliases for SRC gene to outside databases

Previous GC identifers: GC20P035740 GC20P036650 GC20P036696 GC20P036658 GC20P035406 GC20P032708


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SRC Gene:
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the
regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein
kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be
involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have
been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for SRC Gene:
SRC (v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog) is a protein-coding gene. Diseases associated with SRC include colon cancer, advanced, and agammaglobulinemia. GO annotations related to this gene include protein kinase activity and identical protein binding. An important paralog of this gene is FRK.

UniProtKB/Swiss-Prot: SRC_HUMAN, P12931
Function: Non-receptor protein tyrosine kinase which is activated following engagement of many different classes
of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor
protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling
pathways that control a diverse spectrum of biological activities including gene transcription, immune response,
cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy
between members of the SRC kinase family, identification of the specific role of each SRC kinase is very
difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a
role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads
to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor
cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through
phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind
AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the
phosphorylation of cortactin (CTTN). When cells adhere via focal adhesions to the extracellular matrix, signals
are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion
proteins, including PTK2/FAK1 and paxillin (PXN). In addition to phosphorylating focal adhesion proteins, SRC is
also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as
beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap
junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of
pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1. Also plays a role in PDGF-mediated
tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these
transcription factors. Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1. Plays a role in
EGF-mediated calcium-activated chloride channel activation. Required for epidermal growth factor receptor (EGFR)
internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in
beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of ADRBK1, leading to
beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3
mitogen-activated protein kinase cascade by epidermal growth factor. Might be involved not only in mediating the
transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through
the cell cycle via interaction with regulatory proteins in the nucleus. Plays an important role in osteoclastic
bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase
activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating
CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane
in a signaling pathway that is critical for osteoclast function. Promotes energy production in osteoclasts by
activating mitochondrial cytochrome C oxidase. Phosphorylates DDR2 on tyrosine residues, thereby promoting its
subsequent autophosphorylation. Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on
'Tyr-731'. Enhances DDX58/RIG-I-elicited antiviral signaling. Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and
'Tyr-376'. Phosphorylates BCAR1 at 'Tyr-128'. Phosphorylates CBLC at multiple tyrosine residues, phosphorylation
at 'Tyr-341' activates CBLC E3 activity

summary for SRC Gene:
Src kinases consist of eight non-receptor tyrosine kinases (Src, Fyn, Yes, Lck, Lyn, Hck, Fgr and Blk) that
interact with the intracellular domains of growth factor/cytokine receptors, GPCRs and integrins. Members of
the Src kinase family have a very similar domain structure with a high degree of homology in the SH1
(catalytic), linker, SH2 (p-Tyr binding), SH3 (protein-protein interaction) and SH4 (membrane association)
domains. c-Src, Fyn and Yes are ubiquitously expressed, although high levels of c-Src are found in
platelets, neural tissue and osteoclasts. For c-Src, autophosphorylation of Tyr418 and dephosphorylation of
Tyr530 is required to switch the kinase from the inactive closed formation to the active open formation.
c-Src can be inactivated by two kinases, c-Src kinase (CSK) and CSK homologous kinase (CHK), both of which
phosphorylate Tyr530 of c-Src. The activity of the Src kinase family can also be regulated by phosphatases
(e.g. SHP1), binding to adaptor proteins (e.g. Cbp) and proteasomal degradation. Src kinases are key
upstream mediators of both the PI 3-K and MAPK signaling pathways, and have been shown to have important
roles in cell proliferation, migration and survival.

Gene Wiki entry for SRC (Src) Gene

fRNAdb sequence ontologies for SRC - the ORGUL cluster for this gene includes several descriptions:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.
nc_conserved_region - Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for SRC

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the SRC gene promoter:
         CREB   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): SRC promoter sequence
   Search Chromatin IP Primers for SRC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SRC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q12-q13   Ensembl cytogenetic band:  20q11.23   HGNC cytogenetic band: 20q12-q13

SRC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRC gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P035973:  view genomic region     (about GC identifiers)

Start:
35,973,088 bp from pter      End:
36,034,453 bp from pter
Size:
61,366 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for SRC

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SRC_HUMAN, P12931 (See protein sequence)
Recommended Name: Proto-oncogene tyrosine-protein kinase Src  
Size: 536 amino acids; 59835 Da
Subunit: Interacts with DDEF1/ASAP1; via the SH3 domain. Interacts with CCPG1. Identified in a complex containing
FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts with ERBB2, STAT1 and PNN. Interacts with
DDR1, DDR2 and DAB2. Interacts with CDCP1, PELP1, TGFB1I1 and TOM1L2. Interacts with the cytoplasmic domain of
MUC1, phosphorylates it and increases binding of MUC1 with beta-catenin. Interacts with RALGPS1; via the SH3
domain. Interacts with HEV ORF3 protein; via the SH3 domain. Interacts with CAV2 (tyrosine phosphorylated form).
Interacts (via the SH3 domain and the protein kinase domain) with ARRB1; the interaction is independent of the
phosphorylation state of SRC C-terminus. Interacts with ARRB1 and ARRB2. Interacts with SRCIN1. Interacts with
NDFIP2 and more weakly with NDFIP1. Interacts with PIK3CA and/or PIK3C2B, PTK2/FAK1 and ESR1 (dimethylated on
arginine). Interacts with FASLG. Interacts (via SH2 domain) with the 'Tyr-402' phosphorylated form of PTK2B/PYK2.
Interacts (via SH2 domain) with FLT3 (tyrosine phosphorylated). Interacts with PDGFRA (tyrosine phosphorylated).
Interacts with CSF1R. Interacts (via SH2 and SH3 domain) with TNK2. Interacts (via protein kinase domain) with
the tyrosine phosphorylated form of RUNX3 (via runt domain). Interacts with TRAF3 (via RING-type zinc finger
domain). Interacts with DDX58, MAVS and TBK1. Interacts (via SH2 domain) with GNB2L1/RACK1; the interaction is
enhanced by tyrosine phosphorylation of GNB2L1 and inhibits SRC activity. Interacts with EPHB1; activates the
MAPK/ERK cascade to regulate cell migration. Interacts with FCAMR. Interacts (via SH2 domain) with the 'Tyr-9'
phosphorylated form of PDPK1. Interacts with AMOTL2; this interaction regulates the translocation of
phosphorylated SRC to peripheral cell-matrix adhesion sites. Interacts with TRAP1. Interacts with CBLC; the
interaction is enhanced when SRC is phosphorylated at Tyr-419
Selected PDB 3D structures from and Proteopedia for SRC (see all 59):
1A07 (3D)        1A08 (3D)        1A09 (3D)        1A1A (3D)        1A1B (3D)        1A1C (3D)    
Secondary accessions: E1P5V4 Q76P87 Q86VB9 Q9H5A8
Alternative splicing: 2 isoforms:  P12931-1   P12931-2   

Explore the universe of human proteins at neXtProt for SRC: NX_P12931

Explore proteomics data for SRC at MOPED

Post-translational modifications: 

  • Myristoylated at Gly-2, and this is essential for targeting to membranes1
  • Dephosphorylated at Tyr-530 by PTPRJ (By similarity). Phosphorylated on Tyr-530 by c-Src kinase (CSK). The
    phosphorylated form is termed pp60c-src. Dephosphorylated by PTPRJ at Tyr-419. Normally maintained in an inactive
    conformation with the SH2 domain engaged with Tyr-530, the SH3 domain engaged with the SH2-kinase linker, and
    Tyr-419 dephosphorylated. Dephosphorylation of Tyr-530 as a result of protein tyrosine phosphatase (PTP) action
    disrupts the intramolecular interaction between the SH2 domain and Tyr-530, Tyr-419 can then become
    autophosphorylated, resulting in SRC activation. Phosphorylation of Tyr-530 by CSK allows this interaction to
    reform, resulting in SRC inactivation. CDK5-mediated phosphorylation at Ser-75 targets SRC to ubiquitin-dependent
    degradation and thus leads to cytoskeletal reorganization. Phosphorylated by PTK2/FAK1; this enhances kinase
    activity. Phosphorylated by PTK2B/PYK2; this enhances kinase activity1
  • S-nitrosylation is important for activation of its kinase activity (By similarity)1
  • Ubiquitinated in response to CDK5-mediated phosphorylation. Ubiquitination mediated by CBLC requires SRC
    autophosphorylation at Tyr-419 and may lead to lysosomal degradation1
  • Ubiquitination2 at Lys430
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for SRC (P12931) (see all 41)
     DLSFKKG  KWTAPEA  FLEDYFT  DMAAQIA 


    See SRC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_005408.1  NP_938033.1  

    ENSEMBL proteins: 
     ENSP00000362680   ENSP00000362668   ENSP00000362659   ENSP00000408503   ENSP00000353950  
     ENSP00000350941  
    Reactome Protein details: P12931

    SRC Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant SRC Protein
    R&D Systems Recombinant & Natural Proteins for SRC
    Enzo Life Sciences proteins for SRC
    OriGene Purified Proteins for SRC
    OriGene Protein Over-expression Lysate for SRC
    OriGene MassSpec for SRC
    OriGene Custom Protein Services for SRC
    GenScript Custom Purified and Recombinant Proteins Services for SRC
    Novus Biologicals SRC Proteins
    Novus Biologicals SRC Lysates
    Sino Biological Recombinant Protein for SRC
    Sino Biological Cell Lysate for SRC
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SRC

    SRC Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SRC
    R&D Systems Antibodies for SRC
    Cell Signaling Technology (CST) Antibodies for SRC 
    OriGene Antibodies for SRC
    OriGene Custom Antibody Services for SRC
    Novus Biologicals SRC Antibodies
    Abcam antibodies for SRC
    Cloud-Clone Corp. Antibodies for SRC
    ThermoFisher Antibody for SRC
    LSBio Antibodies in human, mouse, rat for SRC

    SRC Assay Products:

    EMD Millipore Kits and Assays for the Analysis of SRC
    OriGene Custom Assay Services for SRC
    R&D Systems ELISAs for SRC         (see all)
    GenScript SRC-Activity-based Kinase Assay for Compound Screening
    Cell Signaling Technology (CST) Sandwich ELISA Kits for SRC
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SRC
    Cloud-Clone Corp. CLIAs for SRC


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SH2D: SH2 domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
    Src family

    Selected InterPro protein domains (see all 8):
     IPR017441 Protein_kinase_ATP_BS
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR011009 Kinase-like_dom
     IPR000980 SH2
     IPR001452 SH3_domain

    Graphical View of Domain Structure for InterPro Entry P12931

    ProtoNet protein and cluster: P12931

    3 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: SRC_HUMAN, P12931
    Domain: The SH2 and SH3 domains are important for the intramolecular and intermolecular interactions that regulate
    catalytic activity, localization, and substrate recruitment
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SH3 domain


    SRC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRC_HUMAN, P12931
    Function: Non-receptor protein tyrosine kinase which is activated following engagement of many different classes
    of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor
    protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling
    pathways that control a diverse spectrum of biological activities including gene transcription, immune response,
    cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy
    between members of the SRC kinase family, identification of the specific role of each SRC kinase is very
    difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a
    role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads
    to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor
    cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through
    phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind
    AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the
    phosphorylation of cortactin (CTTN). When cells adhere via focal adhesions to the extracellular matrix, signals
    are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion
    proteins, including PTK2/FAK1 and paxillin (PXN). In addition to phosphorylating focal adhesion proteins, SRC is
    also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as
    beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap
    junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of
    pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1. Also plays a role in PDGF-mediated
    tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these
    transcription factors. Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1. Plays a role in
    EGF-mediated calcium-activated chloride channel activation. Required for epidermal growth factor receptor (EGFR)
    internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in
    beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of ADRBK1, leading to
    beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3
    mitogen-activated protein kinase cascade by epidermal growth factor. Might be involved not only in mediating the
    transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through
    the cell cycle via interaction with regulatory proteins in the nucleus. Plays an important role in osteoclastic
    bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase
    activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating
    CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane
    in a signaling pathway that is critical for osteoclast function. Promotes energy production in osteoclasts by
    activating mitochondrial cytochrome C oxidase. Phosphorylates DDR2 on tyrosine residues, thereby promoting its
    subsequent autophosphorylation. Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on
    'Tyr-731'. Enhances DDX58/RIG-I-elicited antiviral signaling. Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and
    'Tyr-376'. Phosphorylates BCAR1 at 'Tyr-128'. Phosphorylates CBLC at multiple tyrosine residues, phosphorylation
    at 'Tyr-341' activates CBLC E3 activity
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Phosphorylation by CSK at Tyr-530 inhibits kinase activity. Inhibitory phosphorylation at
    Tyr-530 is enhanced by heme. Further phosphorylation by CDK1 partially reactivates CSK-inactivated SRC and
    facilitates complete reactivation by protein tyrosine phosphatase PTPRC. Integrin engagement stimulates kinase
    activity. Phosphorylation by PTK2/FAK1 enhances kinase activity. Butein and pseudosubstrate-based peptide
    inhibitors like CIYKYYF act as inhibitors. Phosphorylation at Tyr-419 increases kinase activity

         Genatlas biochemistry entry for SRC:
    avian sarcoma (Schmidt-Ruppin A-2) viral (v-src) oncogene homolog

         Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS--
    GO:0004713protein tyrosine kinase activity TAS--
    GO:0004715non-membrane spanning protein tyrosine kinase activity TAS19267251
    GO:0005070SH3/SH2 adaptor activity TAS9020193
    GO:0005102receptor binding IPI19332538
         
    SRC for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for SRC:
     Decreased viability in HMC1.1   Decreased viability with pacli  Increased telomerase activity  Paclitaxel antagonistic effect 

         Selected MGI mutant phenotypes (inferred from 3 alleles(MGI details for Src) (see all 17):
     behavior/neurological  cellular  craniofacial  embryogenesis  growth/size/body 
     hematopoietic system  immune system  integument  limbs/digits/tail  mortality/aging 
     nervous system  pigmentation  reproductive system  respiratory system  skeleton 

    SRC for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Srctm1Sor for SRC

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SRC
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SRC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SRC
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SRC

    miRNA
    Products:
        
    miRTarBase miRNAs that target SRC:
    hsa-mir-33a-5p (MIRT007357), hsa-mir-205-5p (MIRT024971), hsa-mir-23b-3p (MIRT007051)

    Block miRNA regulation of human, mouse, rat SRC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SRC (see all 36):
    hsa-miR-218-1* hsa-miR-200a hsa-miR-16-1* hsa-miR-449a hsa-miR-548l hsa-miR-4267 hsa-miR-877* hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidSRC 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SRC
    Predesigned siRNA for gene silencing in human, mouse, rat SRC

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SRC

    Clone
    Products:
         
    OriGene clones in human, mouse for SRC (see all 14)
    OriGene ORF clones in mouse, rat for SRC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SRC (NM_005417)
    Sino Biological Human cDNA Clone for SRC
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRC

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SRC
    Browse ESI BIO Cell Lines and PureStem Progenitors for SRC 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRC


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SRC_HUMAN, P12931: Cell membrane. Mitochondrion inner membrane. Nucleus. Cytoplasm, cytoskeleton.
    Note=Localizes to focal adhesion sites following integrin engagement. Localization to focal adhesion sites
    requires myristoylation and the SH3 domain
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    endosome5
    lysosome5
    mitochondrion5
    nucleus5
    plasma membrane5
    vacuole5
    cytosol4
    extracellular3
    endoplasmic reticulum2
    golgi apparatus2

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA19767770
    GO:0005743mitochondrial inner membrane IDA12615910
    GO:0005764lysosome IDA--

    SRC for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SRC About   (see all 173)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1ADP signalling through P2Y purinoceptor 12
    Signal amplification0.79
    Development Angiotensin signaling via beta Arrestin0.39
    ADP signalling through P2Y purinoceptor 10.79
    Beta-agonist/Beta-blocker Pathway, Pharmacodynamics0.34
    Thrombin signalling through proteinase activated receptors (PARs)0.69
    2Prolactin Signaling Pathway
    Development Prolactin receptor signaling0.39
    Leptin signaling pathway0.35
    Prolactin Signaling Pathway0.39
    Prolactin signaling pathway0.33
    3Development Slit Robo signaling
    Development Slit Robo signaling0.92
    Neurophysiological process Receptor mediated axon growth repulsion0.41
    Cytoskeleton remodeling Slit Robo signaling0.92
    4Development Endothelin 1 EDNRA signaling
    Development Endothelin 1 EDNRA signaling0.41
    GnRH signaling pathway0.38
    Development Endothelin 1 EDNRA transactivation of EGFR0.41
    Inflammatory mediator regulation of TRP channels0.37
    Cytoskeleton remodeling FAK signaling0.41
    Estrogen signaling pathway0.34
    5Focal adhesion
    Focal adhesion0.65
    Integrin-mediated cell adhesion0.38
    Focal Adhesion0.65

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 R&D Systems Pathways for SRC
        Wnt Signaling Pathways
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways
    VEGF - VEGF R2 Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SRC (see all 56)
        Paxillin Interactions
    Molecular Mechanisms of Cancer
    G12-G13 in Cellular Signaling
    Intracellular Calcium Signaling
    MNAR-PELP1 and Estrogen Receptor Interaction

    2 Cell Signaling Technology (CST) Pathways for SRC
        MAP Kinase Signaling
    Tyrosine Kinases / Adaptors

    1 Tocris Bioscience Pathway for SRC
        MAPK Pathway

    Selected GeneGo (Thomson Reuters) Pathways for SRC (see all 50)
        G-protein signaling H-RAS regulation pathway
    Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
    Development EGFR signaling pathway
    Development Endothelin-1/EDNRA signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins

    Selected BioSystems Pathways for SRC (see all 71)
        Angiogenesis
    Focal Adhesion
    Integrin-mediated cell adhesion
    Senescence and Autophagy
    EGFR1 Signaling Pathway

    1 Sino Biological Pathway for SRC
        EGFR Signaling Pathway

    Selected Reactome Pathways for SRC (see all 24)
        GP1b-IX-V activation signalling
    c-src mediated regulation of Cx43 function and closure of gap junctions
    FCGR activation
    GRB2:SOS provides linkage to MAPK signaling for Integrins
    Signaling by ERBB2

    1 PharmGKB Pathway for SRC
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for SRC) (see all 24):
        ErbB signaling pathway
    Rap1 signaling pathway
    Chemokine signaling pathway
    Endocytosis
    VEGF signaling pathway


    SRC for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SRC (see all 14): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Adherens Junctions in human mouse rat
              Lymphoma in human mouse rat
              VEGF Signaling in human mouse rat
              Tumor Metastasis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SRC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SRC (P129311, 2, 3 ENSP000003509414) via UniProtKB, MINT, STRING, and/or I2D (see all 671)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN1P180311, 2, 3, ENSP000003606834EBI-621482,EBI-968788 MINT-6797096 MINT-6793501 MINT-6794959 MINT-6795286 MINT-6794163 MINT-6764626 MINT-6795447 MINT-6764915 MINT-6795268 MINT-6795409 MINT-6795229 MINT-6794843 MINT-6794810 MINT-6795255 I2D: score=4 STRING: ENSP00000360683
    CBLP226811, 2, 3, ENSP000002640334EBI-621482,EBI-518228 MINT-7040192 MINT-7145443 MINT-7040213 MINT-7040318 MINT-7040304 MINT-3982451 MINT-6539730 MINT-7040120 I2D: score=3 STRING: ENSP00000264033
    MLLT4P551961, 2, 3, ENSP000003836234EBI-621482,EBI-365875 MINT-4950584 MINT-4961227 MINT-4961303 MINT-4961273 MINT-4961253 MINT-4961196 MINT-4961138 I2D: score=1 STRING: ENSP00000383623
    HNRNPKP619781, 2, 3, ENSP000003654394EBI-621482,EBI-304185 MINT-7035298 MINT-7035309 MINT-7035323 MINT-7035338 MINT-7035260 MINT-7035286 I2D: score=4 STRING: ENSP00000365439
    LNX1Q8TBB11, 2, 3, ENSP000002639254EBI-621482,EBI-739832 MINT-6504455 MINT-6504523 MINT-6538383 MINT-6504442 MINT-6504479 MINT-6504500 I2D: score=1 STRING: ENSP00000263925
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 48):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0007049cell cycle IEA--
    GO:0007155cell adhesion IEA--
    GO:0007165signal transduction TAS10734107
    GO:0007172signal complex assembly TAS9924018

    SRC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for SRC
      Browse compounds at ApexBio 

    Compounds for SRC available from Tocris Bioscience    About this table
    CompoundAction CAS #
    1-Naphthyl PP1Src family kinase inhibitor; also inhibits c-Abl[221243-82-9]
    PP 2 Potent, selective Src family kinase inhibitor [172889-27-9]
    PP 3Negative control for PP 2 (Cat. No. 1407)[5334-30-5]
    BosutinibDual Src-Abl inhibitor; antiproliferative[380843-75-4]
    PP 1 Potent, selective Src family kinase inhibitor [172889-26-8]

    2 HMDB Compounds for SRC    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Selected DrugBank Compounds for SRC (see all 44)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Dasatinib-- 302962-49-8targetmultitarget16397263 17429625 11752352 17148760 16230377 17155893
    Citric Acid-- 77-92-9target--17139284 17016423 10592235
    Malonic acidMalonate (see all 2)141-82-2target--17139284 17016423 10592235
    Oxalic Acid-- 144-62-7target--17139284 17016423 10592235
    Phenylphosphate-- --target--17139284 17016423 10592235
    RU78783-- --target--17139284 17016423 10592235
    RU81843-- --target--17139284 17016423 10592235
    RU82129-- --target--17139284 17016423 10592235
    RU82197-- --target--17139284 17016423 10592235
    RU82209-- --target--17139284 17016423 10592235

    Selected Novoseek inferred chemical compound relationships for SRC gene (see all 125)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 94.7 2789 9096689 (6), 11641791 (6), 9331427 (5), 12869565 (5) (see all 99)
    phosphotyrosine 87.5 150 9337879 (2), 10880360 (2), 16611216 (2), 11493667 (2) (see all 99)
    4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine 84.2 18 15618223 (1), 16669788 (1), 19145781 (1), 12739161 (1) (see all 14)
    dasatinib 80.8 80 20406945 (4), 17148760 (4), 19861409 (3), 18619726 (2) (see all 44)
    phosphatidylinositol 80.5 187 1332046 (2), 19372600 (2), 9565618 (2), 12429837 (2) (see all 99)
    ag 1478 79.8 36 11694531 (2), 11160627 (1), 15797859 (1), 17158602 (1) (see all 22)
    herbimycin a 78.4 57 1719464 (4), 9413159 (2), 8514886 (2), 12556363 (2) (see all 36)
    cgp77675 74.8 7 11840778 (1), 14521054 (1), 10833396 (1), 15087474 (1) (see all 6)
    ly294002 67.6 33 10393094 (1), 18854312 (1), 17158602 (1), 20333651 (1) (see all 25)
    phosphoinositide 65.8 59 1311317 (3), 15817454 (2), 15556934 (2), 10880360 (1) (see all 46)



    SRC for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    1 fRNAdb Secondary structure:


    REFSEQ mRNAs for SRC gene (2 alternative transcripts): 
    NM_005417.4  NM_198291.2  

    Unigene Cluster for SRC:

    V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
    Hs.195659  [show with all ESTs]
    Unigene Representative Sequence: NM_005417
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000497734 ENST00000373578(uc002xgy.3) ENST00000373567 ENST00000373558
    ENST00000472968 ENST00000489153 ENST00000477066 ENST00000467556 ENST00000477475
    ENST00000493775 ENST00000445403(uc002xgx.3) ENST00000360723 ENST00000358208

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SRC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SRC (see all 36):
    hsa-miR-218-1* hsa-miR-200a hsa-miR-16-1* hsa-miR-449a hsa-miR-548l hsa-miR-4267 hsa-miR-877* hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidSRC 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SRC
    Predesigned siRNA for gene silencing in human, mouse, rat SRC
    Clone
    Products:
         
    OriGene clones in human, mouse for SRC (see all 14)
    OriGene ORF clones in mouse, rat for SRC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SRC (NM_005417)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRC
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SRC
    OriGene qSTAR qPCR primer pairs in human, mouse for SRC
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SRC
      QuantiTect SYBR Green Assays in human, mouse, rat SRC
      QuantiFast Probe-based Assays in human, mouse, rat SRC

    Additional mRNA sequence: 

    AF272982.1 AK024281.1 BC011566.1 BC051270.1 Z18364.1 

    11 DOTS entries:

    DT.310679  DT.95082049  DT.75101398  DT.100820136  DT.95118917  DT.91929476  DT.95082051  DT.120827952 
    DT.120827971  DT.75180400  DT.95358075 

    Selected AceView cDNA sequences (see all 131):

    CD369263 BE467452 CD364525 BQ941942 BC051270 CD365254 NM_198291 NM_005417 
    AW135290 AI282193 BM352972 CK821940 AW298220 AK024281 BM761470 BE391008 
    BC011566 CA502880 CD620470 AI198134 BM842615 BM824546 BE388654 AX747164 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SRC (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15
    SP1:              -                             -                             -                                   -     -                 -         
    SP2:                                            -                             -                                   -     -                 -         
    SP3:                                                                                                              -     -                 -         
    SP4:                                                                          -                                                                     
    SP5:              -                                                                                                                                 


    ECgene alternative splicing isoforms for SRC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SRC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SRC Expression
    About this image


    SRC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    SRC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SRC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.195659

    UniProtKB/Swiss-Prot: SRC_HUMAN, P12931
    Tissue specificity: Expressed ubiquitously. Platelets, neurons and osteoclasts express 5-fold to 200-fold higher
    levels than most other tissues

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SRC (see all 14): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Adherens Junctions in human mouse rat
              Lymphoma in human mouse rat
              VEGF Signaling in human mouse rat
              Tumor Metastasis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SRC
    OriGene qSTAR qPCR primer pairs in human, mouse for SRC
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SRC
    QuantiTect SYBR Green Assays in human, mouse, rat SRC
    QuantiFast Probe-based Assays in human, mouse, rat SRC
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for SRC gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Src1 , 5 Rous sarcoma oncogene1, 5 90.09(n)1
    99.07(a)1
      2 (78.35 cM)5
    207791  NM_009271.31  NP_033297.21 
     1574184445 
    chicken
    (Gallus gallus)
    Aves SRC1 v-src sarcoma viral oncogene 85.8(n)
    94.75(a)
      396442  NM_205457.2  NP_990788.2 
    lizard
    (Anolis carolinensis)
    Reptilia SRC6
    v-src avian sarcoma (Schmidt-Ruppin A-2) viral onc...
    93(a)
    1 ↔ 1
    GL343291.1(1434759-1542661)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC045134.12   -- 77.6(n)    BC045134.1 
    zebrafish
    (Danio rerio)
    Actinopterygii src1 v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog more 76.06(n)
    84.69(a)
      325084  NM_001003837.2  NP_001003837.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Src64B1 Src oncogene at 64B 57.91(n)
    52.98(a)
      48973  NM_001014563.3  NP_001014563.1 


    ENSEMBL Gene Tree for SRC (if available)
    TreeFam Gene Tree for SRC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for SRC gene
    FRK2  LCK2  BLK2  LYN2  FGR2  PTK62  YES12  HCK2  
    ABL12  FYN2  ABL22  SRMS2  
    Selected SIMAP similar genes for SRC using alignment to 2 protein entries:     SRC_HUMAN (see all proteins) (see all similar genes):
    YES1    FYN    FGR    HCK    BLK    LYN
    JAK1    TNK2    FRK    LCK    EPHB2    EPHB2 variant protein
    EPHA2    EPHA6    TEK    TNK1    ZAK    CD74/ROS fusion

    SRC for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for SRC (see all 1405)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1219133141,2
    Cpathogenic135997839(+) AGTACC/TAGCCC 4 Q * stg10--------
    rs1379463921,2
    --32748395(+) TGTGG-/TTAATG 2 -- int10--------
    rs107145921,2
    C--32748464(+) TGCCT-/TGGCGC 2 -- int12Minor allele frequency- T:0.00NA CSA 4
    rs1422300351,2
    --35937274(+) GGGCCG/TGCACA 1 -- us2k10--------
    rs1512152931,2
    --35937283(+) CAGCAC/TGACAT 1 -- us2k10--------
    rs1401000251,2
    C--35937311(+) AGTGCA/GGTGCC 1 -- us2k10--------
    rs60179161,2
    C,F,A,H--35937404(+) GCTTCA/CACTAG 1 -- us2k125Minor allele frequency- C:0.33NS EA NA WA CSA 2241
    rs60943781,2
    C--35937516(+) GCTGGG/TCTGGG 1 -- us2k14Minor allele frequency- T:0.22WA NA EA 360
    rs743317821,2
    --35937523(+) TGGGGA/CTGGGC 1 -- us2k10--------
    rs1167132121,2
    C,F--35937614(+) GGACAA/GCTCTG 1 -- us2k11Minor allele frequency- G:0.03WA 118

    HapMap Linkage Disequilibrium report for SRC (35973088 - 36034453 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SRC (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2722387CNV Deletion23290073
    esv2722386CNV Deletion23290073
    esv2722388CNV Deletion23290073
    nsv509767CNV Insertion20534489
    dgv510n27CNV Loss19166990
    nsv523618CNV Loss19592680
    nsv528371CNV Loss19592680
    nsv458967CNV Loss19166990
    nsv524059CNV Loss19592680
    nsv833968CNV Gain17160897

    Human Gene Mutation Database (HGMD): SRC
    1 Site Specific Mutation Identification with PCR Assay for SRC:
    Cosmic IdAA Change
    1369p.Q531*
    5 Site Specific Cancer Mutation PCR Panels containing SRC:
    Tyrosine Kinases & Cell Signaling Pathways Panel 384HT
    Oncogene and Tumor Suppressor Panel 384HT
    Lung and Colon Cancers (Expanded Panel) 384HT
    Oncogene Panel 384HT
    Colon Cancer
    SeqTarget long-range PCR primers for resequencing SRC
    DNA2.0 Custom Variant and Variant Library Synthesis for SRC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 190090OMIM information: 217400 605804 607116 608031 608559 610245    
    UniProtKB/Swiss-Prot: SRC_HUMAN, P12931
  • Note=SRC kinase activity has been shown to be increased in several tumor tissues and tumor cell lines
    such as colon carcinoma cells

  • Selected diseases for SRC (see all 137):    
    About MalaCards
    colon cancer, advanced    agammaglobulinemia    cherubism    pneumococcal meningitis
    gallbladder adenocarcinoma    sarcoma    influenza    avian influenza
    desmoid tumor    chronic pain    large granular lymphocyte leukemia    ovarian epithelial cancer
    osteopetrosis    somatostatin analog    waldenstrom macroglobulinemia    hepatitis e
    macroglobulinemia    wiskott-aldrich syndrome    thymoma    hypercalcemia

    11 diseases from the University of Copenhagen DISEASES database for SRC:
    Leukemia     Breast cancer     Sarcoma     Carcinoma
    Colorectal cancer     Vascular disease     Prostate cancer     Lung cancer
    Pancreatic cancer     Osteopetrosis     Malignant glioma

    SRC for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for SRC gene (see all 91)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 59.8 281 19875457 (6), 19307596 (5), 14760089 (4), 15060621 (4) (see all 99)
    breast cancer 59 252 19383905 (5), 9014858 (5), 11007774 (4), 19830888 (4) (see all 99)
    tumors 58.8 397 10022129 (5), 10473101 (5), 18556171 (4), 19690143 (4) (see all 99)
    sarcoma rous 56.1 35 7609076 (3), 7853507 (2), 14969582 (1), 16211495 (1) (see all 21)
    wiskott-aldrich syndrome 53 8 8824280 (3), 8892607 (1), 15673667 (1), 16741966 (1) (see all 6)
    colon cancer 52.7 99 17934522 (5), 9444956 (4), 12939401 (4), 18839319 (4) (see all 47)
    metastasis 50.8 152 7687314 (6), 19383905 (4), 15753384 (4), 9142389 (3) (see all 77)
    x-linked agammaglobulinemia 44.2 2 7519238 (1), 7880320 (1)
    myeloid leukemia chronic 43.4 7 11133737 (1), 10194451 (1), 16611216 (1), 17914733 (1) (see all 7)
    prostate cancer 42.6 70 16894533 (4), 18679417 (4), 20367532 (4), 17426060 (4) (see all 35)

    Genetic Association Database (GAD): SRC
    Human Genome Epidemiology (HuGE) Navigator: SRC (29 documents)
    Tumor Gene Database (TGDB): SRC

    Export disorders for SRC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SRC gene, integrated from 10 sources (see all 3335):
    (articles sorted by number of sources associating them with SRC)
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    1. Human cellular src gene: nucleotide sequence and derived amino acid sequence of the region coding for the carboxy-terminal two-thirds of pp60c-src. (PubMed id 2582238)1, 2, 3 Anderson S.K.... Fujita D.J. (Mol. Cell. Biol. 1985)
    2. Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm. (PubMed id 20100835)1, 2, 9 Goh Y.M.... Bae S.C. (J. Biol. Chem. 2010)
    3. p140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity. (PubMed id 17525734)1, 2, 9 Di Stefano P.... Defilippi P. (EMBO J. 2007)
    4. Regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) by Src involves tyrosine phosphorylation of PDK1 and Src homology 2 domain binding. (PubMed id 18024423)1, 2, 9 Yang K.J.... Park J. (J. Biol. Chem. 2008)
    5. Tyrosine 740 phosphorylation of discoidin domain receptor 2 by Src stimulates intramolecular autophosphorylation and Shc signaling complex formation. (PubMed id 16186108)1, 2, 9 Yang K.... Yang B.S. (J. Biol. Chem. 2005)
    6. EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis. (PubMed id 12925710)1, 2, 9 Vindis C.... Huynh-Do U. (J. Cell Biol. 2003)
    7. The c-Src tyrosine kinase regulates signaling of the human DF3/MUC1 carcinoma-associated antigen with GSK3 beta and beta-catenin. (PubMed id 11152665)1, 2, 9 Li Y.... Kufe D. (J. Biol. Chem. 2001)
    8. RACK1, a receptor for activated C kinase and a homolog of the beta subunit of G proteins, inhibits activity of src tyrosine kinases and growth of NIH 3T3 cells. (PubMed id 9584165)1, 2, 9 Chang B.Y.... Cartwright C.A. (Mol. Cell. Biol. 1998)
    9. Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-c. (PubMed id 22888118)1, 2 Takeshita K....Nakagawa A. (J. Biochem. 2012)
    10. The Cdc42-associated kinase ACK1 is not auto-inhibited but requires Src for activation. (PubMed id 21309750)1, 2 Chan W.... Manser E. (Biochem. J. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6714 HGNC: 11283 AceView: SRC Ensembl:ENSG00000197122 euGenes: HUgn6714
    ECgene: SRC Kegg: 6714 H-InvDB: SRC

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SRC Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SRC Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SRC gene:
    Search GeneIP for patents involving SRC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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