SRBD1 Gene
protein-coding GIFtS: 48
GCID: GC02M045615
|
|
S1 RNA binding domain 1
| |
Aliases
for SRBD1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| S1 RNA Binding Domain 11 2 | | FLJ103791 | | H_NH0576F01.12 | | WUGSC:H_NH0576F01.12 | | S1 RNA-Binding Domain-Containing Protein 12 |
Export aliases for SRBD1 gene to outside databasesPrevious GC identifers: GC02M045469 GC02M045354 |
Summaries
for SRBD1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SRBD1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SRBD1 gene promoter:
Oct-B1 TBP oct-B3 oct-B2 E4BP4 RORalpha1 POU2F1 Nkx6-1 TFIID TGIF
Other transcription factors
Search SABiosciences Chromatin IP Primers for SRBD1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRBD1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p21 Ensembl cytogenetic band: 2p21 HGNC cytogenetic band: 2p21SRBD1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M045615: view genomic region
(about GC identifiers)
Start:
|
45,615,819 bp from pter |
End:
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45,839,304 bp from pter |
Size:
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223,486 bases |
Orientation:
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minus strand |
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Proteins
for SRBD1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SRBD1_HUMAN, Q8N5C6 (See
protein sequence)Recommended Name: S1 RNA-binding domain-containing protein 1 Size: 995 amino acids; 111776 Da
Sequence caution: Sequence=AAY14821.1; Type=Erroneous gene model prediction;
Secondary accessions: Q53T56 Q96TA4 Q9NW11Alternative splicing: 2 isoforms: Q8N5C6-1 Q8N5C6-2 Explore the universe of human proteins at neXtProt for SRBD1: NX_Q8N5C6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N5C6
SRBD1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060549.4
ENSEMBL proteins: ENSP00000263736 ENSP00000441272
Human Recombinant Protein Products for SRBD1:
SRBD1 Antibody Products:
Assay Products for SRBD1: |
Protein
Domains /
Families
for SRBD1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SRBD1 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q8N5C6ProtoNet protein and cluster: Q8N5C6 1 Blocks protein family: IPB003029 RNA binding S1
UniProtKB/Swiss-Prot: SRBD1_HUMAN, Q8N5C6Similarity: Contains 1 S1 motif domain |
Function
for SRBD1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003723 | RNA binding |
IEA | -- | | GO:0016788 | hydrolase activity, acting on ester bonds |
IEA | -- |
SRBD1 for ontologies About GeneDecksing
Phenotypes:
3 GenomeRNAi human phenotypes for SRBD1:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRBD1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRBD1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SRBD1 (NM_018079) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SRBD1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRBD1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRBD1 |
|
Pathways & Interactions
for SRBD1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SRBD1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/7 Interacting proteins for SRBD1 (Q8N5C63 ENSP000002637364) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006139 | nucleobase-containing compound metabolic process |
IEA | -- |
SRBD1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SRBD1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SRBD1
Search CenterWatch for drugs/clinical trials and news about SRBD1
|
Transcripts
for SRBD1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SRBD1 gene: NM_018079.4 Unigene Cluster for SRBD1: S1 RNA binding domain 1 Hs.14229 [show with all ESTs]Unigene Representative Sequence: NM_0180796 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000263736(uc010yoc.2 uc002rus.3) ENST00000490133 ENST00000475073
ENST00000493649 ENST00000461805 ENST00000535761
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRBD1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRBD1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SRBD1 (NM_018079) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SRBD1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRBD1 |
Additional cDNA sequence: AK001241.1 AK055896.1 AK056536.1 AK301122.1 AK316222.1 BC032538.1 5 DOTS entries: DT.452509 DT.100718784 DT.95355916 DT.95250943 DT.99993307 24/92 AceView cDNA sequences (see all 92): AK056536 AI880589 CN482331 CR615345 CB240838 AU124317 AK055896 BX099167 CA310423 CK906214 BE671767 AI655126 AA173044 NM_018079 AI283963 BM127324 CA426893 AL529203 BM449711 BF059599 BQ434016 BX369047 BQ427891 BM969133
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for SRBD1 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SRBD1
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Expression
for SRBD1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SRBD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAAGCCAAAA
About this image
See SRBD1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SRBD1
SOURCE GeneReport for Unigene cluster: Hs.14229
SABiosciences Custom PCR Arrays for SRBD1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SRBD1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SRBD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRBD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRBD1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRBD1 |
Orthologs
for SRBD1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for SRBD1 gene from 7/23 species (see all 23) About this table
ENSEMBL Gene Tree for SRBD1 (if available)
TreeFam Gene Tree for SRBD1 (if available) |
Paralogs
for SRBD1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SRBD1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SRBD1 (45615819 - 45839304 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for SRBD1
6 CNVs: 67667 89625 97836 8368 50503 97837
1 Indel: 89626 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SRBD1 |
|
Disorders
/ Diseases
for SRBD1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SRBD1 for disorders About GeneDecksing
3  diseases for SRBD1: About MalaCardslow tension glaucoma glaucoma pneumonia
1 disease from the University of Copenhagen DISEASES database for SRBD1:Glaucoma Human Genome Epidemiology (HuGE) Navigator: SRBD1 (3 documents)
Export disorders for SRBD1 gene to outside databases
|
Publications
for SRBD1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SRBD1 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with SRBD1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Host cell interactome of HIV-1 Rev includes RNA helica ses involved in multiple facets of virus production. (PubMed id 22174317)1 Naji S....Gerace L. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Genome-wide association study of normal tension glauc oma: common variants in SRBD1 and ELOVL5 contribute to disease susceptibility. (PubMed id 20363506)1 ....Bahram S. (2010)
- System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (2009)
|
External Searches for SRBD1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SRBD1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SRBD1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SRBD1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SRBD1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SRBD1 gene:
Search GeneIP for patents involving SRBD1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SRBD1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SRBD1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SRBD1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SRBD1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SRBD1 | | OriGene 3'-UTR Clone for SRBD1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRBD1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRBD1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SRBD1 | | OriGene Custom Protein Services for SRBD1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SRBD1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SRBD1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRBD1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRBD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRBD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRBD1 |
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 |  |  |  | |
| | | | Search Tocris compounds for SRBD1 |
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 | | | SRBD1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRBD1 |
|  |  |  |  | | | | ThermoFisher Antibodies for SRBD1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRBD1 |
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