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Aliases for SRARP Gene

Aliases for SRARP Gene

  • Steroid Receptor Associated And Regulated Protein 2 3
  • C1orf64 3 4 5
  • Chromosome 1 Open Reading Frame 64 2 5
  • ER-Related Factor 2 3
  • Uncharacterized Protein C1orf64 3
  • ERRF 3

External Ids for SRARP Gene

Previous HGNC Symbols for SRARP Gene

  • C1orf64

Summaries for SRARP Gene

GeneCards Summary for SRARP Gene

SRARP (Steroid Receptor Associated And Regulated Protein) is a Protein Coding gene.

Additional gene information for SRARP Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRARP Gene

Genomics for SRARP Gene

Regulatory Elements for SRARP Gene

Enhancers for SRARP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H015947 2 FANTOM5 Ensembl ENCODE dbSUPER 8.5 -53.1 -53058 7 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF766 FOS DEK SP3 JUNB HSPB7 CLCNKA PLEKHM2 ZBTB17 SPEN ENSG00000233078 CROCC RPL22P3 FBLIM1 ENSG00000237938
GH01H015882 2 FANTOM5 Ensembl ENCODE dbSUPER 8.4 -118.9 -118924 5 HDGF PKNOX1 ARNT ARID4B DMAP1 ZNF2 YY1 ZNF766 DEK SP3 HSPB7 SPEN FLJ37453 CLCNKA EIF1AXP1 SRARP PLEKHM2 ZBTB17 EFHD2 GC01P015874
GH01H015829 2 FANTOM5 Ensembl ENCODE dbSUPER 7.3 -170.2 -170236 9 MLX FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC ZC3H11A PPARGC1A MEF2D ZBTB17 FAM231A SPEN ENSG00000237938 CROCC CLCNKA NECAP2 CD24P1 RNU1-1 FLJ37453
GH01H015777 1.2 ENCODE dbSUPER 12.1 -224.4 -224352 4 PKNOX1 FOXA2 ARID4B SIN3A YY1 ZNF121 ZNF766 REST PPARG KAT8 FBLIM1 ENSG00000237938 SLC25A34 SRARP ARHGEF19 CLCNKB CASP9 RPL12P14
GH01H015974 1.4 ENCODE dbSUPER 9.6 -28.6 -28596 2 HDGF PKNOX1 MLX ARNT ARID4B SIN3A ZNF2 ZBTB7B YY1 SLC30A9 HSPB7 CROCCP3 LINC01772 CROCC SRARP TBC1D3P6 ENSG00000234607
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SRARP on UCSC Golden Path with GeneCards custom track

Genomic Location for SRARP Gene

Chromosome:
1
Start:
16,004,236 bp from pter
End:
16,008,807 bp from pter
Size:
4,572 bases
Orientation:
Plus strand

Genomic View for SRARP Gene

Genes around SRARP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRARP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRARP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRARP Gene

Proteins for SRARP Gene

  • Protein details for SRARP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEQ6-CA064_HUMAN
    Recommended name:
    Uncharacterized protein C1orf64
    Protein Accession:
    Q8NEQ6
    Secondary Accessions:
    • B3KXI9

    Protein attributes for SRARP Gene

    Size:
    169 amino acids
    Molecular mass:
    17657 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SRARP Gene

Post-translational modifications for SRARP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SRARP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SRARP Gene

Domains & Families for SRARP Gene

Gene Families for SRARP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SRARP Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SRARP: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SRARP Gene

Function for SRARP Gene

Phenotypes From GWAS Catalog for SRARP Gene

genes like me logo Genes that share phenotypes with SRARP: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SRARP
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SRARP Gene

Localization for SRARP Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRARP gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SRARP Gene

Pathways & Interactions for SRARP Gene

SuperPathways for SRARP Gene

No Data Available

Interacting Proteins for SRARP Gene

Selected Interacting proteins: Q8NEQ6-CA064_HUMAN for SRARP Gene via IID

Symbol External ID(s) Details
APP

Gene Ontology (GO) - Biological Process for SRARP Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SRARP Gene

Drugs & Compounds for SRARP Gene

No Compound Related Data Available

Transcripts for SRARP Gene

mRNA/cDNA for SRARP Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SRARP
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SRARP Gene

No ASD Table

Relevant External Links for SRARP Gene

GeneLoc Exon Structure for
SRARP
ECgene alternative splicing isoforms for
SRARP

Expression for SRARP Gene

NURSA nuclear receptor signaling pathways regulating expression of SRARP Gene:

SRARP
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRARP Gene

Orthologs for SRARP Gene

This gene was present in the common ancestor of mammals.

Orthologs for SRARP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1orf64 34
  • 99 (a)
OneToOne
C1H1orf64 33
  • 98.62 (n)
cow
(Bos Taurus)
Mammalia C2H1orf64 34 33
  • 71.78 (n)
OneToOne
dog
(Canis familiaris)
Mammalia C1orf64 34
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm694 34 33
  • 64.4 (n)
OneToOne
Srarp 16
rat
(Rattus norvegicus)
Mammalia RGD1566083 33
  • 64.36 (n)
Species where no ortholog for SRARP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SRARP Gene

ENSEMBL:
Gene Tree for SRARP (if available)
TreeFam:
Gene Tree for SRARP (if available)

Paralogs for SRARP Gene

No data available for Paralogs for SRARP Gene

Variants for SRARP Gene

Sequence variations from dbSNP and Humsavar for SRARP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_035491 A breast cancer sample
VAR_035492 A breast cancer sample
rs1000173300 -- 16,005,062(+) AGCGG(G/T)GGGAT intron-variant
rs1000775103 -- 16,004,049(+) ATAGT(A/G)TCTGT upstream-variant-2KB
rs1001083012 -- 16,003,790(+) CACCC(A/G)TCTTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SRARP Gene

Variant ID Type Subtype PubMed ID
nsv508936 CNV insertion 20534489
nsv517651 CNV gain+loss 19592680
nsv520148 CNV loss 19592680
nsv524045 CNV loss 19592680
nsv545627 CNV loss 21841781
nsv833758 CNV gain+loss 17160897
nsv997887 CNV gain 25217958

Variation tolerance for SRARP Gene

Residual Variation Intolerance Score: 83.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.07; 21.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRARP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRARP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRARP Gene

Disorders for SRARP Gene

Relevant External Links for SRARP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRARP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRARP

No disorders were found for SRARP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRARP Gene

Publications for SRARP Gene

  1. ERRF is essential for Estrogen-Estrogen Receptor alpha signaling pathway in ER positive breast cancer cells. (PMID: 27125460) Luo A … Zhang X (Biochemical and biophysical research communications 2016) 2 3 60
  2. Role of ERRF, a novel ER-related nuclear factor, in the growth control of ER-positive human breast cancer cells. (PMID: 22341523) Su D … Dong JT (The American journal of pathology 2012) 2 3 60
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for SRARP Gene

Sources for SRARP Gene

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