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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SRA1 Gene

protein-coding   GIFtS: 48
GCID: GC05M139911

steroid receptor RNA activator 1

(Previous name: steriod receptor RNA activator 1 )
 Explore 13 diseases affiliated with
SRA1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SRA1    

Aliases
for SRA1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 5

Aliases
Steroid Receptor RNA Activator 11 2     Steriod Receptor RNA Activator 11
SRA1 2     Pp76841
STRAA11 2     Steroid Receptor Coactivator2
Steroid Receptor RNA Activator Protein2 3     Steroid Receptor RNA Activator 1 (Complexes With NCOA1)2
SRAP2 3     

External Ids:    HGNC: 112811   Entrez Gene: 100112   Ensembl: ENSG000002135237   OMIM: 6038195   UniProtKB: Q9HD153   
ORGUL members:    fRNAdb10:FR017440 FR043009 FR043043 FR087841 FR256784      
NCBI:AF092038 AF293024 AF293026 AF293025 XR_000132    
NONCODE:u748 n790 n343053    
RNAdb:LIT1246 LIT1251 LIT1250 LIT1245    

Export aliases for SRA1 gene to outside databases

Previous GC identifers: GC05M139746 GC05M140512 GC05M139912 GC05M139958 GC05M139909 GC05M135074


Summaries
for SRA1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SRA1:
Both long non-coding and protein-coding RNAs are transcribed from this gene, and they represent alternatively spliced
transcript variants. This gene was initially defined as a non-coding RNA, which is a coactivator for several nuclear
receptors (NRs) and is associated with breast cancer. It has now been found that this gene is involved in the
regulation of many NR and non-NR activities, including metabolism, adipogenesis and chromatin organization. The long
non-coding RNA transcripts interact with a variety of proteins, including the protein encoded by this gene. The
encoded protein acts as a transcriptional repressor by binding to the non-coding RNA. (provided by RefSeq, Mar 2012)

UniProtKB/Swiss-Prot: SRA1_HUMAN, Q9HD15
Function: Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid
receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain
(AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently
through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis
in vivo. May play a role in tumorigenesis

Gene Wiki entry for SRA1

fRNAdb sequence ontology for SRA1:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for SRA1

Genomic Views
for SRA1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_029289.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SRA1 gene promoter:
         CREB   TBP   p53   NRSF form 1   deltaCREB   TFIID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SRA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SRA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.3   Ensembl cytogenetic band:  5q31.3   HGNC cytogenetic band: 5q31

SRA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRA1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M139911:  view genomic region     (about GC identifiers)

Start:
 139,929,653 bp from pter      End:
 139,937,895 bp from pter
Size:
 8,243 bases      Orientation:
 minus strand
ORGUL member locations:
Legend (see complete legend)

  • n343053
  • FR0256784
  • n790
  • FR0017440
  • FR0043043
  • FR0043009
  • FR0087841
139929652 139933665 139937678 chr5

Proteins
for SRA1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SRA1_HUMAN, Q9HD15 (See protein sequence)
Recommended Name: Steroid receptor RNA activator 1  
Size: 236 amino acids; 25673 Da
Subunit: SRA1 RNA exists in a ribonucleoprotein complex containing NCOA1. The RNA also forms a complex with PUS1 and
RARG in the nucleus. Interacts with AR
Subcellular location: Nucleus. Cytoplasm
Miscellaneous: Appears to be the first example of a new class of functional RNAs also able to encode a protein
Sequence caution: Sequence=AAH40043.2; Type=Frameshift; Positions=29;
Secondary accessions: Q6NVU9 Q8IXM1 Q9HD13 Q9HD14

Explore the universe of human proteins at neXtProt for SRA1: NX_Q9HD15

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9HD15

    • SRA1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001030312.2  NP_001240693.1  

    ENSEMBL proteins: 
     ENSP00000337513   ENSP00000430066  

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    Uscn Proteins for SRA1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12565891
    GO:0005667transcription factor complex IEA--
    GO:0005737cytoplasm IEA--
    GO:0030529ribonucleoprotein complex IPI10199399
    GO:0031252cell leading edge IEA--


    SRA1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SRA1

    Protein Domains /
    Families
    for SRA1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SRA1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR009917 SRA1-protein/COPII_Sec31

    Graphical View of Domain Structure for InterPro Entry Q9HD15

    ProtoNet protein and cluster: Q9HD15

    UniProtKB/Swiss-Prot: SRA1_HUMAN, Q9HD15
    Similarity: Belongs to the SRA1 family


    Function
    for SRA1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SRA1_HUMAN, Q9HD15
    Function: Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid
    receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain
    (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently
    through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis
    in vivo. May play a role in tumorigenesis

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SRA1
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate SRA1:
    hsa-miR-203 hsa-miR-3910 hsa-miR-4307 hsa-miR-2117 hsa-miR-3202 hsa-miR-627 hsa-miR-26b* hsa-miR-4273
    SwitchGear 3'UTR luciferase reporter plasmid: SRA1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for SRA1

    In Situ Assay
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    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003713transcription coactivator activity IDA10199399
    GO:0004872receptor activity ----
    GO:0005515protein binding ----
    GO:0010861thyroid hormone receptor activator activity IEA--


    SRA1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SRA1:
     Synthetic lethal with c-Myc af 


    Pathways & Interactions
    for SRA1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1GPCR Pathway
    		Estrogen Pathway0.55

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SRA1
        Estrogen Pathway


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SRA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/20 Interacting proteins for SRA1 (Q9HD152, 3 ENSP000003375134) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAB4AP203382, 3MINT-63548 I2D: score=1 
    HDAC2Q927692, 3, ENSP000003813314MINT-7761068 MINT-7722319 I2D: score=1 STRING: ENSP00000381331
    DDX5P178443, ENSP000002257924I2D: score=1 STRING: ENSP00000225792
    NCOA2Q155963, ENSP000003999684I2D: score=1 STRING: ENSP00000399968
    SPENQ96T583, ENSP000003649124I2D: score=1 STRING: ENSP00000364912
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006915apoptotic process IDA14517287
    GO:0008283cell proliferation IDA14517287
    GO:0030154cell differentiation IDA14517287
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IEA--


    SRA1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SRA1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SRA1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SRA1
    4 Novoseek chemical compound relationships for SRA1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    steroid 74.5 63 10199399 (4), 20219889 (2), 17710122 (2), 16848684 (2) (see all 40)
    estrogen 64 11 11250900 (3), 12943696 (2), 15351741 (2), 16497729 (1) (see all 7)
    4-hydroxytamoxifen 52.1 2 15351741 (2)
    tamoxifen 43.2 5 16762838 (1), 16152589 (1), 20332317 (1), 15351741 (1)

    Search CenterWatch for drugs/clinical trials and news about SRA1 

    Transcripts
    for SRA1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    		 5 fRNAdb Secondary structures:


    REFSEQ mRNAs for SRA1 gene (2 alternative transcripts): 
    NM_001035235.3  NM_001253764.1  

    Unigene Cluster for SRA1:

    Steroid receptor RNA activator 1
    Hs.653135  [show with all ESTs]
    Unigene Representative Sequence: AK054960
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336283(uc003lfz.3 uc021yef.1 uc003lga.3 uc010jfm.3)
    ENST00000523259 ENST00000520427

    miRNA
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    8 QIAGEN miScript miRNA Assays for microRNAs that regulate SRA1:
    hsa-miR-203 hsa-miR-3910 hsa-miR-4307 hsa-miR-2117 hsa-miR-3202 hsa-miR-627 hsa-miR-26b* hsa-miR-4273
    SwitchGear 3'UTR luciferase reporter plasmid: SRA1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SRA1 (see all 7)
    OriGene shRNA RFP: SRA1
    OriGene siRNA: SRA1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRA1
    Clone
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    GenScript: all cDNA clones in your preferred vector: SRA1 (NM_001035235)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRA1 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SRA1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRA1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRA1

    Additional cDNA sequence: 

    AF092038.1 AF293024.1 AF293025.1 AF293026.1 AF318361.1 AK024640.1 AK054960.1 BC040043.2 
    BC067895.1 DQ286291.1 NR_045586.1 NR_045587.1 

    13 DOTS entries:

    DT.120809089  DT.100815438  DT.92437826  DT.120809155  DT.95166975  DT.446147  DT.40225209  DT.100031485 
    DT.120809049  DT.95166855  DT.100041909  DT.100815437  DT.100881056 

    24/420 AceView cDNA sequences (see all 420):

    BU687231 AU279932 BQ052761 AI524742 AW952597 BU625023 CD358859 BQ006470 
    AW135683 AA378875 CA431393 AB049618 BG113610 AI207238 BU737788 NM_133172 
    CA426519 NM_133175 AA804604 W49526 CB853471 BM717898 BM980607 AA833851 

    GeneLoc Exon Structure


    Expression
    for SRA1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SRA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See SRA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SRA1

    SOURCE GeneReport for Unigene cluster: Hs.653135

    UniProtKB/Swiss-Prot: SRA1_HUMAN, Q9HD15
    Tissue specificity: Highly expressed in liver and skeletal muscle and to a lesser extent in brain. Also expressed in
    both normal and tumorigenic breast epithelial cell lines. Significantly up-regulated in human tumors of the breast,
    ovary, and uterus

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    In Situ
    Assay Products:     
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    Orthologs
    for SRA1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for SRA1 gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Sra11 , 5 steroid receptor RNA activator 11, 5 85.71(n)1
    83.98(a)1    		   18 (19.46 cM)5
    240681  NM_025291.31  NP_079567.21 
     366666815 
    chicken
    (Gallus gallus)    		 Aves SRA16
    		 Uncharacterized protein
    		 49(a)
    		 1 ↔ 1
    		 13(1548186-1549035)
    lizard
    (Anolis carolinensis)    		 Reptilia SRA16
    		 --
    		 53(a)
    		 1 ↔ 1
    		 4(77923289-77927139)
    zebrafish
    (Danio rerio)    		 Actinopterygii sra11 steroid receptor RNA activator 1 54.02(n)
    50.74(a)    		   415137  NM_001002047.1  NP_001002047.1 


    ENSEMBL Gene Tree for SRA1 (if available)
    TreeFam Gene Tree for SRA1 (if available) 

    Paralogs
    for SRA1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for SRA1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/232 NCBI SNPs in SRA1 are shown (see all 232)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1156787381,2
    		C,F,--135075097(+) GTTCTA/CATCTC 4 -- ut31 nc-transcript-variant1Minor allele frequency- C:0.03WA 118
    rs155171,2
    		C,F,H--135075123(+) TCAAGG/TGTGAT 4 -- ut31 nc-transcript-variant3Minor allele frequency- T:0.01MN NS 456
    rs68897681,2
    		C,F,H,--135075216(+) AACCAT/GCCAAA 4 -- nc-transcript-variantut319Minor allele frequency- G:0.03NS EA NA 1192
    rs356445221,2
    		F--135075354(-) CCCTGCTCC    
       CTG    /-    TGTAT     		4 -- ut31 nc-transcript-variant5Minor allele frequency- -:0.01MN 404
    rs1133233951,2
    		C,--135075406(+) GGAAGG/TGTTCA 4 -- ut31 nc-transcript-variant2Minor allele frequency- T:0.05CSA WA 120
    rs350701901,2
    		C,F,--135075468(-) GTGTTA/TCTCAT 4 -- nc-transcript-variantut317Minor allele frequency- T:0.03MN CSA WA 524
    rs354903891,2
    		C,F,--135075479(-) AGGGAG/ATTCAT 4 -- nc-transcript-variantut316Minor allele frequency- A:0.04MN WA 522
    rs10470101,2
    		C--135075495(-) GTCCCA/CCCTGG 4 -- ut31 nc-transcript-variant7Minor allele frequency- C:0.00MN NA 590
    rs32105051,2
    		C,A,H--135075592(-) ACCATC/TTCCTA 4 -- ut31 nc-transcript-variant10Minor allele frequency- T:0.00MN NS EA 1004
    rs775446931,2
    		--135076210(+) ATTCTG/AGTTCT 4 -- int11Minor allele frequency- A:0.01WA 118

    HapMap Linkage Disequilibrium report for SRA1 (139929653 - 139937895 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SRA1: --

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    Disorders / Diseases
    for SRA1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SRA1 for disorders           About GeneDecksing

    OMIM gene information: 603819   
    13 diseases for SRA1:    About MalaCards
    breast cancer    infective endocarditis    sporadic breast cancer    endocarditis
    epithelial ovarian cancer    ovarian cancer    meningioma    endometrial cancer
    pulmonary disease    cardiomyopathy    prostate cancer    prostatitis
    thyroiditis

    3 Novoseek disease relationships for SRA1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 34.6 16 16152589 (3), 17710122 (2), 19483093 (2), 16848684 (2) (see all 10)
    meningioma 22.8 1 10999746 (1)
    tumors 0 5 16152589 (2), 16762838 (1), 19483093 (1)

    Human Genome Epidemiology (HuGE) Navigator: SRA1 (18 documents)

    Export disorders for SRA1 gene to outside databases

    Publications
    for SRA1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SRA1 gene, integrated from 9 sources (see all 92):
    (articles sorted by number of sources associating them with SRA1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex. (PubMed id 10199399)1, 2, 3, 9 Lanz R.B.... O'Malley B.W. (1999)
    2. Ligand-independent coactivation of ERalpha AF-1 by steroid receptor RNA activator (SRA) via MAPK activation. (PubMed id 12943696)1, 2, 9 Deblois G. and Giguere V. (2003)
    3. SRA coactivation of estrogen receptor-alpha is phosphorylation- independent, and enhances 4-hydroxytamoxifen agonist activity. (PubMed id 15351741)1, 2, 9 Coleman K.M.... Smith C.L. (2004)
    4. Identification of new human coding steroid receptor RNA activator isoforms. (PubMed id 12565891)1, 2, 9 Emberley E.... Leygue E. (2003)
    5. The steroid receptor RNA activator is the first functional RNA encoding a protein. (PubMed id 15147866)1, 2, 9 Chooniedass-Kothari S.... Leygue E. (2004)
    6. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Steroid receptor RNA activator stimulates proliferation as well as apoptosis in vivo. (PubMed id 14517287)1, 2 Lanz R.B.... O'Malley B.W. (2003)
    9. Research resource: expression profiling reveals unexp ected targets and functions of the human steroid receptor RNA activator (SRA) g ene. (PubMed id 20219889)1, 9 Foulds C.E....O'Malley B.W. (2010)
    10. Alternative splicing of the first intron of the steroid receptor RNA activator (SRA) participates in the generation of coding and noncoding RNA isoforms in breast cancer cell lines. (PubMed id 16848684)1, 9 Hube F....Leygue E. (2006)

    External Searches for SRA1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing SRA1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10011 HGNC: 11281 AceView: APBB3andSRA1 Ensembl:ENSG00000213523 euGenes: HUgn10011
    ECgene: SRA1 H-InvDB: SRA1

    Other Databases showing SRA1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SRA1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SRA1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SRA1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SRA1 gene:
    Search GeneIP for patents involving SRA1

    GeneCards and IP:
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