Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SRA1 Gene

Aliases for SRA1 Gene

  • Steroid Receptor RNA Activator 1 2 3 5
  • Steroid Receptor RNA Activator Protein 3 4
  • SRAP 3 4
  • Steroid Receptor RNA Activator 1 (Complexes With NCOA1) 3
  • Steriod Receptor RNA Activator 1 2
  • Steroid Receptor Coactivator 3
  • STRAA1 3
  • Pp7684 3
  • SRA 3

External Ids for SRA1 Gene

Previous GeneCards Identifiers for SRA1 Gene

  • GC05M139746
  • GC05M140512
  • GC05M139912
  • GC05M139958
  • GC05M139909
  • GC05M139911
  • GC05M135074

Summaries for SRA1 Gene

Entrez Gene Summary for SRA1 Gene

  • Both long non-coding and protein-coding RNAs are transcribed from this gene, and they represent alternatively spliced transcript variants. This gene was initially defined as a non-coding RNA, which is a coactivator for several nuclear receptors (NRs) and is associated with breast cancer. It has now been found that this gene is involved in the regulation of many NR and non-NR activities, including metabolism, adipogenesis and chromatin organization. The long non-coding RNA transcripts interact with a variety of proteins, including the protein encoded by this gene. The encoded protein acts as a transcriptional repressor by binding to the non-coding RNA. [provided by RefSeq, Mar 2012]

GeneCards Summary for SRA1 Gene

SRA1 (Steroid Receptor RNA Activator 1) is a Protein Coding gene. Diseases associated with SRA1 include Trachea Leiomyoma and Anterograde Amnesia. Among its related pathways are GPCR Pathway. GO annotations related to this gene include transcription coactivator activity and ligand-dependent nuclear receptor transcription coactivator activity.

UniProtKB/Swiss-Prot for SRA1 Gene

  • Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.

Gene Wiki entry for SRA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRA1 Gene

Genomics for SRA1 Gene

Regulatory Elements for SRA1 Gene

Enhancers for SRA1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F140344 1.6 FANTOM5 Ensembl ENCODE 23 +211.2 211151 5.8 PKNOX1 SIN3A ARID4B ZNF2 ZNF48 GLIS2 FOS ZNF263 SP3 TSHZ1 SRA1 HARS PFDN1 HBEGF APBB3 CD14 PCDHA7 ANKHD1 ENSG00000253965
GH05F140601 1.4 FANTOM5 Ensembl ENCODE 23.6 -44.3 -44344 2.0 HDAC1 MLX SIN3A YY1 EGR2 THAP11 ZNF263 USF2 CEBPB ZNF589 APBB3 CD14 TMCO6 SRA1 SLC35A4 MIR6831 MIR3655 IK NDUFA2 EIF4EBP3
GH05F140606 1.3 FANTOM5 Ensembl 24 -48.8 -48782 0.9 ELF3 ARID4B ZSCAN9 RAD21 RARA YY1 SLC30A9 CREM MIXL1 THAP11 APBB3 SRA1 CD14 SLC35A4 MIR6831 EIF4EBP3 MIR3655 NDUFA2 IK HBEGF
GH05F140594 1.3 FANTOM5 Ensembl ENCODE 20.9 -37.7 -37749 4.0 NFIA MIER1 CREB3L1 CEBPB MIER2 REST ZIC2 YY1 ZNF766 ATF3 CD14 APBB3 SRA1 TMCO6 PCDHA1 PCDHA2 HARS SLC35A4 MIR6831 PCDHA5
GH05F140555 1.1 ENCODE 22 +1.1 1140 3.3 HDGF CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF207 SRA1 CD14 EIF4EBP3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SRA1 on UCSC Golden Path with GeneCards custom track

Promoters for SRA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001291847 1252 1601 HDGF CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 SP3

Genomic Location for SRA1 Gene

Chromosome:
5
Start:
140,537,340 bp from pter
End:
140,558,252 bp from pter
Size:
20,913 bases
Orientation:
Minus strand

Genomic View for SRA1 Gene

Genes around SRA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRA1 Gene

Proteins for SRA1 Gene

  • Protein details for SRA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HD15-SRA1_HUMAN
    Recommended name:
    Steroid receptor RNA activator 1
    Protein Accession:
    Q9HD15
    Secondary Accessions:
    • Q6NVU9
    • Q8IXM1
    • Q9HD13
    • Q9HD14

    Protein attributes for SRA1 Gene

    Size:
    236 amino acids
    Molecular mass:
    25673 Da
    Quaternary structure:
    • SRA1 RNA exists in a ribonucleoprotein complex containing NCOA1. The RNA also forms a complex with PUS1 and RARG in the nucleus. Interacts with AR.
    Miscellaneous:
    • Appears to be the first example of a new class of functional RNAs also able to encode a protein.
    SequenceCaution:
    • Sequence=AAH40043.2; Type=Frameshift; Positions=29; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SRA1 Gene

neXtProt entry for SRA1 Gene

Post-translational modifications for SRA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SRA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SRA1 Gene

Domains & Families for SRA1 Gene

Protein Domains for SRA1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9HD15

UniProtKB/Swiss-Prot:

SRA1_HUMAN :
  • Belongs to the SRA1 family.
Family:
  • Belongs to the SRA1 family.
genes like me logo Genes that share domains with SRA1: view

No data available for Gene Families for SRA1 Gene

Function for SRA1 Gene

Molecular function for SRA1 Gene

UniProtKB/Swiss-Prot Function:
Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.

Gene Ontology (GO) - Molecular Function for SRA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IDA 10199399
GO:0005515 protein binding IPI 16595694
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity IBA --
genes like me logo Genes that share ontologies with SRA1: view
genes like me logo Genes that share phenotypes with SRA1: view

Animal Models for SRA1 Gene

MGI Knock Outs for SRA1:
  • Sra1 tm1a(EUCOMM)Hmgu
  • Sra1 tm1b(EUCOMM)Hmgu

Animal Model Products

miRNA for SRA1 Gene

miRTarBase miRNAs that target SRA1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SRA1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SRA1 Gene

Localization for SRA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRA1 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRA1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 5
nucleus 5
cytosol 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SRA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 12565891
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
GO:0015630 microtubule cytoskeleton IDA --
genes like me logo Genes that share ontologies with SRA1: view

Pathways & Interactions for SRA1 Gene

SuperPathway Contained pathways
1 GPCR Pathway
genes like me logo Genes that share pathways with SRA1: view

Pathways by source for SRA1 Gene

1 Qiagen pathway for SRA1 Gene

Gene Ontology (GO) - Biological Process for SRA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006915 apoptotic process IEA --
GO:0008283 cell proliferation IDA 14517287
GO:0030154 cell differentiation IDA 14517287
genes like me logo Genes that share ontologies with SRA1: view

No data available for SIGNOR curated interactions for SRA1 Gene

Drugs & Compounds for SRA1 Gene

(2) Drugs for SRA1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for SRA1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SRA1: view

Transcripts for SRA1 Gene

Unigene Clusters for SRA1 Gene

Steroid receptor RNA activator 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SRA1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRA1 Gene

No ASD Table

Relevant External Links for SRA1 Gene

GeneLoc Exon Structure for
SRA1
ECgene alternative splicing isoforms for
SRA1

Expression for SRA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SRA1 Gene

mRNA differential expression in normal tissues according to GTEx for SRA1 Gene

This gene is overexpressed in Whole Blood (x4.4).

Protein differential expression in normal tissues from HIPED for SRA1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.2) and Monocytes (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SRA1 Gene



Protein tissue co-expression partners for SRA1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SRA1 Gene:

SRA1

SOURCE GeneReport for Unigene cluster for SRA1 Gene:

Hs.653135

mRNA Expression by UniProt/SwissProt for SRA1 Gene:

Q9HD15-SRA1_HUMAN
Tissue specificity: Highly expressed in liver and skeletal muscle and to a lesser extent in brain. Also expressed in both normal and tumorigenic breast epithelial cell lines. Significantly up-regulated in human tumors of the breast, ovary, and uterus.
genes like me logo Genes that share expression patterns with SRA1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SRA1 Gene

Orthologs for SRA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SRA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRA1 34 35
  • 99.72 (n)
cow
(Bos Taurus)
Mammalia SRA1 34 35
  • 89.49 (n)
dog
(Canis familiaris)
Mammalia SRA1 34 35
  • 85.95 (n)
mouse
(Mus musculus)
Mammalia Sra1 34 16 35
  • 85.28 (n)
rat
(Rattus norvegicus)
Mammalia Sra1 34
  • 83.41 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 57 (a)
OneToMany
-- 35
  • 39 (a)
OneToMany
chicken
(Gallus gallus)
Aves SRA1 35
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRA1 35
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sra1 34
  • 57.48 (n)
zebrafish
(Danio rerio)
Actinopterygii sra1 34 35
  • 56.45 (n)
Species where no ortholog for SRA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SRA1 Gene

ENSEMBL:
Gene Tree for SRA1 (if available)
TreeFam:
Gene Tree for SRA1 (if available)

Paralogs for SRA1 Gene

No data available for Paralogs for SRA1 Gene

Variants for SRA1 Gene

Sequence variations from dbSNP and Humsavar for SRA1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10463297 -- 140,556,654(+) TGGAC(C/T)TCCTG intron-variant
rs1047010 -- 140,550,571(-) GTCCC(A/C)CCTGG nc-transcript-variant, utr-variant-3-prime
rs10589076 -- 140,552,194(+) AAAGG(A/T)ACAGC intron-variant
rs110346 -- 140,559,429(-) gatta(G/T)gatga intron-variant, upstream-variant-2KB
rs110347 -- 140,559,364(-) aggcc(A/C)attag intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SRA1 Gene

Variant ID Type Subtype PubMed ID
nsv462462 CNV loss 19166990
nsv599825 CNV loss 21841781

Variation tolerance for SRA1 Gene

Residual Variation Intolerance Score: 86.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.68; 98.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRA1 Gene

Human Gene Mutation Database (HGMD)
SRA1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRA1 Gene

Disorders for SRA1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SRA1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
trachea leiomyoma
  • tracheal neoplasm
anterograde amnesia
  • amnesia, anterograde
spinal muscular atrophy-3
  • spinal muscular atrophy, type iii, modifier of
- elite association - COSMIC cancer census association via MalaCards
Search SRA1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SRA1

Genetic Association Database (GAD)
SRA1
Human Genome Epidemiology (HuGE) Navigator
SRA1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRA1
genes like me logo Genes that share disorders with SRA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SRA1 Gene

Publications for SRA1 Gene

  1. A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex. (PMID: 10199399) Lanz R.B. … O'Malley B.W. (Cell 1999) 2 3 4 22 64
  2. The steroid receptor RNA activator is the first functional RNA encoding a protein. (PMID: 15147866) Chooniedass-Kothari S. … Leygue E. (FEBS Lett. 2004) 3 4 22 64
  3. SRA coactivation of estrogen receptor-alpha is phosphorylation- independent, and enhances 4-hydroxytamoxifen agonist activity. (PMID: 15351741) Coleman K.M. … Smith C.L. (Biochem. Biophys. Res. Commun. 2004) 3 4 22 64
  4. Identification of new human coding steroid receptor RNA activator isoforms. (PMID: 12565891) Emberley E. … Leygue E. (Biochem. Biophys. Res. Commun. 2003) 3 4 22 64
  5. Ligand-independent coactivation of ERalpha AF-1 by steroid receptor RNA activator (SRA) via MAPK activation. (PMID: 12943696) Deblois G. … Giguere V. (J. Steroid Biochem. Mol. Biol. 2003) 3 4 22 64

Products for SRA1 Gene

Sources for SRA1 Gene

Content
Loading form....