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Aliases for SRA1 Gene

Aliases for SRA1 Gene

  • Steroid Receptor RNA Activator 1 2 3
  • Steroid Receptor RNA Activator Protein 3 4
  • SRAP 3 4
  • Steroid Receptor RNA Activator 1 (Complexes With NCOA1) 3
  • Steriod Receptor RNA Activator 1 2
  • Steroid Receptor Coactivator 3
  • STRAA1 3
  • Pp7684 3
  • SRA 3

External Ids for SRA1 Gene

Previous GeneCards Identifiers for SRA1 Gene

  • GC05M139746
  • GC05M140512
  • GC05M139912
  • GC05M139958
  • GC05M139909
  • GC05M139911
  • GC05M135074

Summaries for SRA1 Gene

Entrez Gene Summary for SRA1 Gene

  • Both long non-coding and protein-coding RNAs are transcribed from this gene, and they represent alternatively spliced transcript variants. This gene was initially defined as a non-coding RNA, which is a coactivator for several nuclear receptors (NRs) and is associated with breast cancer. It has now been found that this gene is involved in the regulation of many NR and non-NR activities, including metabolism, adipogenesis and chromatin organization. The long non-coding RNA transcripts interact with a variety of proteins, including the protein encoded by this gene. The encoded protein acts as a transcriptional repressor by binding to the non-coding RNA. [provided by RefSeq, Mar 2012]

GeneCards Summary for SRA1 Gene

SRA1 (Steroid Receptor RNA Activator 1) is a Protein Coding gene. Diseases associated with SRA1 include campomelic dysplasia and breast cancer. Among its related pathways are GPCR Pathway. GO annotations related to this gene include transcription coactivator activity and thyroid hormone receptor activator activity.

UniProtKB/Swiss-Prot for SRA1 Gene

  • Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.

Gene Wiki entry for SRA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRA1 Gene

Genomics for SRA1 Gene

Regulatory Elements for SRA1 Gene

Genomic Location for SRA1 Gene

Start:
140,537,340 bp from pter
End:
140,558,310 bp from pter
Size:
20,971 bases
Orientation:
Minus strand

Genomic View for SRA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SRA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRA1 Gene

Proteins for SRA1 Gene

  • Protein details for SRA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HD15-SRA1_HUMAN
    Recommended name:
    Steroid receptor RNA activator 1
    Protein Accession:
    Q9HD15
    Secondary Accessions:
    • Q6NVU9
    • Q8IXM1
    • Q9HD13
    • Q9HD14

    Protein attributes for SRA1 Gene

    Size:
    236 amino acids
    Molecular mass:
    25673 Da
    Quaternary structure:
    • SRA1 RNA exists in a ribonucleoprotein complex containing NCOA1. The RNA also forms a complex with PUS1 and RARG in the nucleus. Interacts with AR.
    Miscellaneous:
    • Appears to be the first example of a new class of functional RNAs also able to encode a protein.
    SequenceCaution:
    • Sequence=AAH40043.2; Type=Frameshift; Positions=29; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SRA1 Gene

neXtProt entry for SRA1 Gene

Proteomics data for SRA1 Gene at MOPED

Post-translational modifications for SRA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SRA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SRA1 Gene

Domains for SRA1 Gene

Protein Domains for SRA1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9HD15

UniProtKB/Swiss-Prot:

SRA1_HUMAN :
  • Q9HD15
Family:
  • Belongs to the SRA1 family.
genes like me logo Genes that share domains with SRA1: view

No data available for Gene Families for SRA1 Gene

Function for SRA1 Gene

Molecular function for SRA1 Gene

UniProtKB/Swiss-Prot Function: Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.

Gene Ontology (GO) - Molecular Function for SRA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IDA 10199399
GO:0005515 protein binding IPI 16595694
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity IBA --
genes like me logo Genes that share ontologies with SRA1: view

Phenotypes for SRA1 Gene

GenomeRNAi human phenotypes for SRA1:
genes like me logo Genes that share phenotypes with SRA1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SRA1 Gene

Localization for SRA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRA1 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRA1 Gene COMPARTMENTS Subcellular localization image for SRA1 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for SRA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12565891
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
GO:0015630 microtubule cytoskeleton IDA --
genes like me logo Genes that share ontologies with SRA1: view

Pathways for SRA1 Gene

SuperPathways for SRA1 Gene

Superpath Contained pathways
1 GPCR Pathway
genes like me logo Genes that share pathways with SRA1: view

Pathways by source for SRA1 Gene

1 Qiagen pathway for SRA1 Gene

Gene Ontology (GO) - Biological Process for SRA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006915 apoptotic process IEA --
GO:0008283 cell proliferation IDA 14517287
GO:0030154 cell differentiation IDA 14517287
genes like me logo Genes that share ontologies with SRA1: view

Compounds for SRA1 Gene

(4) Novoseek inferred chemical compound relationships for SRA1 Gene

Compound -log(P) Hits PubMed IDs
steroid 74.5 48
estrogen 64 11
4-hydroxytamoxifen 52.1 2
tamoxifen 43.2 4
genes like me logo Genes that share compounds with SRA1: view

Transcripts for SRA1 Gene

Unigene Clusters for SRA1 Gene

Steroid receptor RNA activator 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SRA1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SRA1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRA1 Gene

No ASD Table

Relevant External Links for SRA1 Gene

GeneLoc Exon Structure for
SRA1
ECgene alternative splicing isoforms for
SRA1

Expression for SRA1 Gene

mRNA expression in normal human tissues for SRA1 Gene

mRNA differential expression in normal tissues according to GTEx for SRA1 Gene

This gene is overexpressed in Whole Blood (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SRA1 Gene

SOURCE GeneReport for Unigene cluster for SRA1 Gene Hs.653135

mRNA Expression by UniProt/SwissProt for SRA1 Gene

Q9HD15-SRA1_HUMAN
Tissue specificity: Highly expressed in liver and skeletal muscle and to a lesser extent in brain. Also expressed in both normal and tumorigenic breast epithelial cell lines. Significantly up-regulated in human tumors of the breast, ovary, and uterus.
genes like me logo Genes that share expressions with SRA1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SRA1 Gene

Orthologs for SRA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SRA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRA1 35
  • 99.72 (n)
  • 100 (a)
SRA1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SRA1 35
  • 89.49 (n)
  • 86.04 (a)
SRA1 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRA1 35
  • 85.95 (n)
  • 82.06 (a)
SRA1 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sra1 35
  • 85.28 (n)
  • 82.68 (a)
Sra1 16
Sra1 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
OneToMany
-- 36
  • 39 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Sra1 35
  • 83.41 (n)
  • 80.95 (a)
chicken
(Gallus gallus)
Aves SRA1 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRA1 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sra1 35
  • 57.48 (n)
  • 56.12 (a)
zebrafish
(Danio rerio)
Actinopterygii sra1 35
  • 56.45 (n)
  • 54.27 (a)
sra1 36
  • 50 (a)
OneToOne
Species with no ortholog for SRA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SRA1 Gene

ENSEMBL:
Gene Tree for SRA1 (if available)
TreeFam:
Gene Tree for SRA1 (if available)

Paralogs for SRA1 Gene

No data available for Paralogs for SRA1 Gene

Variants for SRA1 Gene

Sequence variations from dbSNP and Humsavar for SRA1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs15517 -- 140,550,199(+) TCAAG(G/T)GTGAT utr-variant-3-prime, nc-transcript-variant
rs250426 -- 140,557,175(+) GCGGC(A/G/T)ACCCT synonymous-codon, reference, stop-gained, missense, nc-transcript-variant
rs250427 -- 140,557,395(-) TAGGT(A/C/G/T)GTCGC intron-variant, missense, reference, nc-transcript-variant
rs397863 -- 140,557,516(-) CTCAA(C/T)TGGCC utr-variant-5-prime, upstream-variant-2KB, nc-transcript-variant
rs431546 -- 140,557,414(-) AGCCG(C/G)CGGGC intron-variant, synonymous-codon, reference, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for SRA1 Gene

Variant ID Type Subtype PubMed ID
nsv462462 CNV Loss 19166990

Relevant External Links for SRA1 Gene

HapMap Linkage Disequilibrium report
SRA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRA1 Gene

Disorders for SRA1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for SRA1 Gene including...

Search for SRA1 Gene in MalaCards »

(3) Novoseek inferred disease relationships for SRA1 Gene

Disease -log(P) Hits PubMed IDs
breast cancer 34.6 15
meningioma 22.8 1
tumors 0 4

Relevant External Links for SRA1

Genetic Association Database (GAD)
SRA1
Human Genome Epidemiology (HuGE) Navigator
SRA1
genes like me logo Genes that share disorders with SRA1: view

No data available for UniProtKB/Swiss-Prot for SRA1 Gene

Publications for SRA1 Gene

  1. A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex. (PMID: 10199399) Lanz R.B. … O'Malley B.W. (Cell 1999) 2 3 4 23
  2. Identification of new human coding steroid receptor RNA activator isoforms. (PMID: 12565891) Emberley E. … Leygue E. (Biochem. Biophys. Res. Commun. 2003) 3 4 23
  3. Ligand-independent coactivation of ERalpha AF-1 by steroid receptor RNA activator (SRA) via MAPK activation. (PMID: 12943696) Deblois G. … Giguere V. (J. Steroid Biochem. Mol. Biol. 2003) 3 4 23
  4. The steroid receptor RNA activator is the first functional RNA encoding a protein. (PMID: 15147866) Chooniedass-Kothari S. … Leygue E. (FEBS Lett. 2004) 3 4 23
  5. SRA coactivation of estrogen receptor-alpha is phosphorylation- independent, and enhances 4-hydroxytamoxifen agonist activity. (PMID: 15351741) Coleman K.M. … Smith C.L. (Biochem. Biophys. Res. Commun. 2004) 3 4 23

Products for SRA1 Gene

  • Addgene plasmids for SRA1

Sources for SRA1 Gene

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