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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SRA1 Gene

protein-coding   GIFtS: 52
GCID: GC05M139911

Steroid Receptor RNA Activator 1

(Previous name: steriod receptor RNA activator 1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Steroid Receptor RNA Activator 11 2     STRAA12
Steroid Receptor RNA Activator Protein2 3     pp76842
SRAP2 3     Steroid Receptor Coactivator2
Steriod Receptor RNA Activator 11     Steroid Receptor RNA Activator 1 (Complexes With NCOA1)2
SRA2     

External Ids:    HGNC: 112811   Entrez Gene: 100112   Ensembl: ENSG000002135237   OMIM: 6038195   UniProtKB: Q9HD153   

Export aliases for SRA1 gene to outside databases

Previous GC identifers: GC05M139746 GC05M140512 GC05M139912 GC05M139958 GC05M139909 GC05M135074


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SRA1 Gene:
Both long non-coding and protein-coding RNAs are transcribed from this gene, and they represent alternatively
spliced transcript variants. This gene was initially defined as a non-coding RNA, which is a coactivator for
several nuclear receptors (NRs) and is associated with breast cancer. It has now been found that this gene is
involved in the regulation of many NR and non-NR activities, including metabolism, adipogenesis and chromatin
organization. The long non-coding RNA transcripts interact with a variety of proteins, including the protein
encoded by this gene. The encoded protein acts as a transcriptional repressor by binding to the non-coding RNA.
(provided by RefSeq, Mar 2012)

GeneCards Summary for SRA1 Gene: 
SRA1 (steroid receptor RNA activator 1) is a protein-coding gene. Diseases associated with SRA1 include mn1, and infective endocarditis, and among its related super-pathways are GPCR Pathway. GO annotations related to this gene include thyroid hormone receptor activator activity and transcription coactivator activity.

UniProtKB/Swiss-Prot: SRA1_HUMAN, Q9HD15
Function: Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid
receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal
domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors
ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation
and promotes apoptosis in vivo. May play a role in tumorigenesis

Gene Wiki entry for SRA1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_029289.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SRA1 gene promoter:
         CREB   TBP   p53   NRSF form 1   deltaCREB   TFIID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SRA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SRA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.3   Ensembl cytogenetic band:  5q31.3   HGNC cytogenetic band: 5q31

SRA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRA1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M139911:  view genomic region     (about GC identifiers)

Start:
139,916,925 bp from pter      End:
139,937,895 bp from pter
Size:
20,971 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SRA1_HUMAN, Q9HD15 (See protein sequence)
Recommended Name: Steroid receptor RNA activator 1  
Size: 236 amino acids; 25673 Da
Subunit: SRA1 RNA exists in a ribonucleoprotein complex containing NCOA1. The RNA also forms a complex with PUS1
and RARG in the nucleus. Interacts with AR
Subcellular location: Nucleus. Cytoplasm
Miscellaneous: Appears to be the first example of a new class of functional RNAs also able to encode a protein
Sequence caution: Sequence=AAH40043.2; Type=Frameshift; Positions=29;
Secondary accessions: Q6NVU9 Q8IXM1 Q9HD13 Q9HD14

Explore the universe of human proteins at neXtProt for SRA1: NX_Q9HD15

Explore proteomics data for SRA1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9HD15

  • SRA1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SRA1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001030312.2  NP_001240693.1  

    ENSEMBL proteins: 
     ENSP00000473378   ENSP00000337513  

    Human Recombinant Protein Products for SRA1: 
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    Novus Biologicals SRA1 Protein
    Novus Biologicals SRA1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for SRA1
    Cloud-Clone Corp. Proteins for SRA1 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12565891
    GO:0005667transcription factor complex IEA--
    GO:0005737cytoplasm IEA--
    GO:0030529ribonucleoprotein complex IPI10199399
    GO:0031252cell leading edge IEA--

    SRA1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR009917 SRA1-protein/COPII_Sec31

    Graphical View of Domain Structure for InterPro Entry Q9HD15

    ProtoNet protein and cluster: Q9HD15

    UniProtKB/Swiss-Prot: SRA1_HUMAN, Q9HD15
    Similarity: Belongs to the SRA1 family


    SRA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRA1_HUMAN, Q9HD15
    Function: Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid
    receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal
    domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors
    ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation
    and promotes apoptosis in vivo. May play a role in tumorigenesis

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003713transcription coactivator activity IDA10199399
    GO:0005515protein binding IPI16595694
    GO:0010861thyroid hormone receptor activator activity IEA--
    GO:0030374ligand-dependent nuclear receptor transcription coactivator activity IEA--
         
    SRA1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SRA1:
     Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SRA1 
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    miRNA
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    8 QIAGEN miScript miRNA Assays for microRNAs that regulate SRA1:
    hsa-miR-203 hsa-miR-3910 hsa-miR-4307 hsa-miR-2117 hsa-miR-3202 hsa-miR-627 hsa-miR-26b* hsa-miR-4273
    SwitchGear 3'UTR luciferase reporter plasmidSRA1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SRA1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1GPCR Pathway
    Estrogen Pathway0.55

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SRA1
        Estrogen Pathway


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SRA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/20 Interacting proteins for SRA1 (Q9HD152, 3 ENSP000003375134) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAB4AP203382, 3MINT-63548 I2D: score=1 
    HDAC2Q927692, 3, ENSP000003813314MINT-7761068 MINT-7722319 I2D: score=1 STRING: ENSP00000381331
    DDX5P178443, ENSP000002257924I2D: score=1 STRING: ENSP00000225792
    NCOA2Q155963, ENSP000003999684I2D: score=1 STRING: ENSP00000399968
    SPENQ96T583, ENSP000003649124I2D: score=1 STRING: ENSP00000364912
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0008283cell proliferation IDA14517287
    GO:0030154cell differentiation IDA14517287
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IEA--
    GO:0097194execution phase of apoptosis IDA14517287

    SRA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SRA1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SRA1

    4 Novoseek inferred chemical compound relationships for SRA1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    steroid 74.5 63 10199399 (4), 20219889 (2), 17710122 (2), 16848684 (2) (see all 40)
    estrogen 64 11 11250900 (3), 12943696 (2), 15351741 (2), 16497729 (1) (see all 7)
    4-hydroxytamoxifen 52.1 2 15351741 (2)
    tamoxifen 43.2 5 16762838 (1), 16152589 (1), 20332317 (1), 15351741 (1)

    Search CenterWatch for drugs/clinical trials and news about SRA1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SRA1 gene (2 alternative transcripts): 
    NM_001035235.3  NM_001253764.1  

    Unigene Cluster for SRA1:

    Steroid receptor RNA activator 1
    Hs.653135  [show with all ESTs]
    Unigene Representative Sequence: AK054960
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000602657 ENST00000602775 ENST00000336283(uc003lfz.3 uc021yef.1 uc003lga.3 uc010jfm.3)
    ENST00000523259 ENST00000602875 ENST00000520427
    miRNA
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    8 QIAGEN miScript miRNA Assays for microRNAs that regulate SRA1:
    hsa-miR-203 hsa-miR-3910 hsa-miR-4307 hsa-miR-2117 hsa-miR-3202 hsa-miR-627 hsa-miR-26b* hsa-miR-4273
    SwitchGear 3'UTR luciferase reporter plasmidSRA1 3' UTR sequence
    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRA1
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRA1
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRA1

    Additional mRNA sequence: 

    AF092038.1 AF293024.1 AF293025.1 AF293026.1 AF318361.1 AK024640.1 AK054960.1 BC040043.2 
    BC067895.1 DQ286291.1 NR_045586.1 NR_045587.1 

    13 DOTS entries:

    DT.120809089  DT.100815438  DT.92437826  DT.120809155  DT.95166975  DT.446147  DT.40225209  DT.100031485 
    DT.120809049  DT.95166855  DT.100041909  DT.100815437  DT.100881056 

    24/420 AceView cDNA sequences (see all 420):

    BM680258 AW291759 BQ945280 AA829599 BE900150 NM_133174 BU736185 AA402264 
    CA431393 AI524742 BU625023 BE793975 NM_133176 NM_133172 BM473616 BQ052761 
    AA378875 BE265437 CA426519 BQ575210 AW135683 CR595828 AW515175 BM460451 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SRA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SRA1 Expression
    About this image


    See SRA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SRA1

    SOURCE GeneReport for Unigene cluster: Hs.653135

    UniProtKB/Swiss-Prot: SRA1_HUMAN, Q9HD15
    Tissue specificity: Highly expressed in liver and skeletal muscle and to a lesser extent in brain. Also expressed
    in both normal and tumorigenic breast epithelial cell lines. Significantly up-regulated in human tumors of the
    breast, ovary, and uterus

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SRA1 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sra11 , 5 steroid receptor RNA activator 11, 5 85.71(n)1
    83.98(a)1
      18 (19.46 cM)5
    240681  NM_025291.31  NP_079567.21 
     366666815 
    chicken
    (Gallus gallus)
    Aves SRA16
    steroid receptor RNA activator 1
    44(a)
    1 ↔ 1
    13(1095133-1095980)
    lizard
    (Anolis carolinensis)
    Reptilia SRA16
    steroid receptor RNA activator 1
    51(a)
    1 ↔ 1
    4(77923151-77926928)
    zebrafish
    (Danio rerio)
    Actinopterygii sra11 steroid receptor RNA activator 1 54.02(n)
    50.74(a)
      415137  NM_001002047.1  NP_001002047.1 


    ENSEMBL Gene Tree for SRA1 (if available)
    TreeFam Gene Tree for SRA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/299 SNPs in SRA1 are shown (see all 299)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs609981201,2
    C--139934175(+) ACTGT-/TTAACTA 4 -- int10--------
    rs1122510461,2
    C,F--139934715(+) CCTTGG/TCCTCC 4 -- int11Minor allele frequency- T:0.50NA 2
    rs353842931,2
    C--139936270(+) TTTTT-/T/TT  
            
    CTCAC
    4 -- int11NA 2
    rs1822973511,2
    --140205867(+) GGGCTC/GTTCCT 4 -- ds50010--------
    rs737917261,2
    C,F--140205926(+) CTCCCC/TTATCC 4 -- ds50011Minor allele frequency- T:0.50WA 2
    rs1381977201,2
    --140206033(+) GTTCCC/TCTATT 4 -- ds50010--------
    rs1412325421,2
    --140206051(+) CAAAAA/TCCTTG 4 -- ds50010--------
    rs1156787381,2
    C,F--140206246(+) GTTCTA/CATCTC 4 -- ut31 nc-transcript-variant1Minor allele frequency- C:0.03WA 118
    rs155171,2
    C,F,H--140206272(+) TCAAGG/TGTGAT 4 -- ut31 nc-transcript-variant3Minor allele frequency- T:0.01MN NS 456
    rs1867380491,2
    --140206310(+) TTGTTC/GAGGGA 4 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for SRA1 (139916925 - 139937895 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SRA1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv462462CNV Loss19166990


    Human Gene Mutation Database (HGMD): SRA1
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for SRA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603819    OMIM disorders: --

    12 diseases for SRA1:    About MalaCards
    mn1    infective endocarditis    endocarditis    sporadic breast cancer
    meningioma    breast cancer    narcolepsy    ovarian cancer
    prostate cancer    thyroiditis    prostatitis    lung cancer


    SRA1 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for SRA1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 34.6 16 16152589 (3), 17710122 (2), 19483093 (2), 16848684 (2) (see all 10)
    meningioma 22.8 1 10999746 (1)
    tumors 0 5 16152589 (2), 16762838 (1), 19483093 (1)

    Genetic Association Database (GAD): SRA1
    Human Genome Epidemiology (HuGE) Navigator: SRA1 (18 documents)

    Export disorders for SRA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SRA1 gene, integrated from 9 sources (see all 93):
    (articles sorted by number of sources associating them with SRA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex. (PubMed id 10199399)1, 2, 3, 9 Lanz R.B.... O'Malley B.W. (1999)
    2. Ligand-independent coactivation of ERalpha AF-1 by steroid receptor RNA activator (SRA) via MAPK activation. (PubMed id 12943696)1, 2, 9 Deblois G. and Giguere V. (2003)
    3. SRA coactivation of estrogen receptor-alpha is phosphorylation- independent, and enhances 4-hydroxytamoxifen agonist activity. (PubMed id 15351741)1, 2, 9 Coleman K.M.... Smith C.L. (2004)
    4. Identification of new human coding steroid receptor RNA activator isoforms. (PubMed id 12565891)1, 2, 9 Emberley E.... Leygue E. (2003)
    5. The steroid receptor RNA activator is the first functional RNA encoding a protein. (PubMed id 15147866)1, 2, 9 Chooniedass-Kothari S.... Leygue E. (2004)
    6. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (2010)
    7. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
    8. PTEN identified as important risk factor of chronic o bstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (2009)
    9. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1, 4 Vega A....Carracedo A. (2009)
    10. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10011 HGNC: 11281 AceView: APBB3andSRA1 Ensembl:ENSG00000213523 euGenes: HUgn10011
    ECgene: SRA1 H-InvDB: SRA1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SRA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SRA1 gene:
    Search GeneIP for patents involving SRA1

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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