Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SQSTM1 Gene

Aliases for SQSTM1 Gene

  • Sequestosome 1 2 3 5
  • Phosphotyrosine-Independent Ligand For The Lck SH2 Domain Of 62 KDa 3 4
  • EBI3-Associated Protein Of 60 KDa 3 4
  • Oxidative Stress Induced Like 2 3
  • Ubiquitin-Binding Protein P62 3 4
  • EBIAP 3 4
  • OSIL 3 4
  • P60 3 4
  • Phosphotyrosine Independent Ligand For The Lck SH2 Domain P62 3
  • EBI3-Associated Protein P60 3
  • Paget Disease Of Bone 3 2
  • FTDALS3 3
  • ORCA 4
  • ZIP3 3
  • A170 3
  • P62B 3
  • PDB3 3
  • P62 3

External Ids for SQSTM1 Gene

Previous HGNC Symbols for SQSTM1 Gene

  • PDB3
  • OSIL

Previous GeneCards Identifiers for SQSTM1 Gene

  • GC05P179360
  • GC05P180192
  • GC05P179297
  • GC05P179358
  • GC05P179359
  • GC05P179181
  • GC05P179234
  • GC05P173959

Summaries for SQSTM1 Gene

Entrez Gene Summary for SQSTM1 Gene

  • This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009]

GeneCards Summary for SQSTM1 Gene

SQSTM1 (Sequestosome 1) is a Protein Coding gene. Diseases associated with SQSTM1 include frontotemporal dementia and/or amyotrophic lateral sclerosis 3 and paget disease of bone 3. Among its related pathways are Signaling by GPCR and Immune System. GO annotations related to this gene include protein homodimerization activity and protein serine/threonine kinase activity.

UniProtKB/Swiss-Prot for SQSTM1 Gene

  • Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels.

Gene Wiki entry for SQSTM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SQSTM1 Gene

Genomics for SQSTM1 Gene

Regulatory Elements for SQSTM1 Gene

Promoters for SQSTM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SQSTM1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the SQSTM1 gene promoter:

Genomic Location for SQSTM1 Gene

Chromosome:
5
Start:
179,806,388 bp from pter
End:
179,838,078 bp from pter
Size:
31,691 bases
Orientation:
Plus strand

Genomic View for SQSTM1 Gene

Genes around SQSTM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SQSTM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SQSTM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SQSTM1 Gene

Proteins for SQSTM1 Gene

  • Protein details for SQSTM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13501-SQSTM_HUMAN
    Recommended name:
    Sequestosome-1
    Protein Accession:
    Q13501
    Secondary Accessions:
    • A6NFN7
    • B2R661
    • B3KUW5
    • Q13446
    • Q9BUV7
    • Q9BVS6
    • Q9UEU1

    Protein attributes for SQSTM1 Gene

    Size:
    440 amino acids
    Molecular mass:
    47687 Da
    Quaternary structure:
    • Homooligomer or heterooligomer; may form homotypic arrays. Dimerization interferes with ubiquitin binding. Interacts directly with PRKCI and PRKCZ (Probable). Forms ternary complexes with PRKCZ and KCNAB2 or PRKCZ and GABBR3. Also interacts with KCNAB1, GABRR1, GABRR2 and GABRR3. Forms an NGF-induced complex with IKBKB, PRKCI and TRAF6 (By similarity). Interacts with EBI3, LCK, RASA1, PRKCZ, PRKCI, NR2F2, NTRK1, NTRK2, NTRK3, NBR1, MAP2K5, TRIM13, TRIM55 and MAPKAPK5. Interacts with the proteasome subunits PSMD4 and PSMC2. Interacts with K63-polyubiquitinated MAPT/TAU. Interacts with IKBKB through PRKCZ and PRKCI. Interacts with NGFR through TRAF6 and bridges that complex to NTRK1. Forms a complex with MAP2K5 and PRKCZ or PRKCI. Component of a ternary complex with PAWR and PRKCZ. Upon TNF-alpha stimulation, interacts with RIPK1 problably bridging IKBKB to the TNF-R1 complex composed of TNF-R1/TNFRSF1A, TRADD and RIPK1. Forms a complex with JUB/Ajuba, PRKCZ and TRAF6. Interacts with TRAF6 and CYLD. Identified in a complex with TRAF6 and CYLD (By similarity). Identified in a heterotrimeric complex with ubiquitin and ZFAND5, where ZFAND5 and SQSTM1 both interact with the same ubiquitin molecule. Directly interacts with MAP1LC3A and MAP1LC3B, as well as with other MAP1 LC3 family members, including GABARAP, GABARAPL1 and GABARAPL2; these interactions are necessary for the recruitment MAP1 LC3 family members to inclusion bodies containing polyubiquitinated protein aggregates and for their degradation by autophagy. Interacts with FHOD3. Interacts with TRMI5.

    Three dimensional structures from OCA and Proteopedia for SQSTM1 Gene

    Alternative splice isoforms for SQSTM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SQSTM1 Gene

Proteomics data for SQSTM1 Gene at MOPED

Post-translational modifications for SQSTM1 Gene

  • Phosphorylated. May be phosphorylated by PRKCZ (By similarity). Phosphorylated in vitro by TTN.
  • Ubiquitination at Lys 141, Lys 157, Lys 165, Lys 313, and Lys 435
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SQSTM1 (SQSTM1)

No data available for DME Specific Peptides for SQSTM1 Gene

Domains & Families for SQSTM1 Gene

Gene Families for SQSTM1 Gene

Protein Domains for SQSTM1 Gene

Suggested Antigen Peptide Sequences for SQSTM1 Gene

Graphical View of Domain Structure for InterPro Entry

Q13501

UniProtKB/Swiss-Prot:

SQSTM_HUMAN :
  • The UBA domain binds specifically Lys-63-linked polyubiquitin chains of polyubiquitinated substrates. Mediates the interaction with TRIM55. Both the UBA and PB1 domains are necessary and sufficient for the localization into the ubiquitin-containing inclusion bodies.
  • Contains 1 ZZ-type zinc finger.
Domain:
  • The UBA domain binds specifically Lys-63-linked polyubiquitin chains of polyubiquitinated substrates. Mediates the interaction with TRIM55. Both the UBA and PB1 domains are necessary and sufficient for the localization into the ubiquitin-containing inclusion bodies.
  • The PB1 domain mediates homooligomerization and interactions with FHOD3, MAP2K5, NBR1, PRKCI and PRKCZ. Both the PB1 and UBA domains are necessary and sufficient for the localization into the ubiquitin-containing inclusion bodies.
  • The ZZ-type zinc finger mediates the interaction with RIPK1.
  • The LIR (LC3-interacting region) motif mediates the interaction with ATG8 family proteins.
  • Contains 1 PB1 domain.
  • Contains 1 UBA domain.
Similarity:
  • Contains 1 ZZ-type zinc finger.
genes like me logo Genes that share domains with SQSTM1: view

Function for SQSTM1 Gene

Molecular function for SQSTM1 Gene

UniProtKB/Swiss-Prot Function:
Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels.
UniProtKB/Swiss-Prot Induction:
By proteasomal inhibitor PSI and prostaglandin J2 (PGJ2) (at protein level). By phorbol 12-myristate 13-acetate (PMA).

Gene Ontology (GO) - Molecular Function for SQSTM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030971 receptor tyrosine kinase binding TAS 8650207
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with SQSTM1: view
genes like me logo Genes that share phenotypes with SQSTM1: view

Human Phenotype Ontology for SQSTM1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SQSTM1 Gene

MGI Knock Outs for SQSTM1:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SQSTM1 Gene

Localization for SQSTM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SQSTM1 Gene

Cytoplasm. Late endosome. Lysosome. Cytoplasmic vesicle, autophagosome. Nucleus. Endoplasmic reticulum. Cytoplasm, P-body. Note=Sarcomere (By similarity). In cardiac muscles localizes to the sarcomeric band (By similarity). Commonly found in inclusion bodies containing polyubiquitinated protein aggregates. In neurodegenerative diseases, detected in Lewy bodies in Parkinson disease, neurofibrillary tangles in Alzheimer disease, and HTT aggregates in Huntington disease. In protein aggregate diseases of the liver, found in large amounts in Mallory bodies of alcoholic and nonalcoholic steatohepatitis, hyaline bodies in hepatocellular carcinoma, and in SERPINA1 aggregates. Enriched in Rosenthal fibers of pilocytic astrocytoma. In the cytoplasm, observed in both membrane-free ubiquitin-containing protein aggregates (sequestosomes) and membrane-surrounded autophagosomes. Colocalizes with TRIM13 in the perinuclear endoplasmic reticulum. Co-localizes with TRIM5 in the cytoplasmic bodies. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SQSTM1 Gene COMPARTMENTS Subcellular localization image for SQSTM1 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
endosome 5
extracellular 5
lysosome 5
nucleus 5
vacuole 5
mitochondrion 2
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SQSTM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005770 late endosome IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0016605 PML body IDA 20168092
GO:0031410 cytoplasmic vesicle IEA --
GO:0044753 amphisome IDA 19640926
genes like me logo Genes that share ontologies with SQSTM1: view

Pathways & Interactions for SQSTM1 Gene

genes like me logo Genes that share pathways with SQSTM1: view

SIGNOR curated interactions for SQSTM1 Gene

Gene Ontology (GO) - Biological Process for SQSTM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000423 macromitophagy TAS --
GO:0006468 protein phosphorylation NAS 8618896
GO:0006511 ubiquitin-dependent protein catabolic process TAS 8702753
GO:0006914 autophagy TAS 19816510
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with SQSTM1: view

Drugs & Compounds for SQSTM1 Gene

(6) Drugs for SQSTM1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for SQSTM1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SQSTM1: view

Transcripts for SQSTM1 Gene

Unigene Clusters for SQSTM1 Gene

Sequestosome 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SQSTM1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11 ^ 12 ^ 13a ·
SP1: - - - -
SP2: -
SP3: -
SP4: - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - -
SP7: - - -
SP8: - - -
SP9: -
SP10: -
SP11: -
SP12:
SP13: -

ExUns: 13b ^ 14a · 14b ^ 15a · 15b · 15c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for SQSTM1 Gene

GeneLoc Exon Structure for
SQSTM1
ECgene alternative splicing isoforms for
SQSTM1

Expression for SQSTM1 Gene

mRNA expression in normal human tissues for SQSTM1 Gene

mRNA differential expression in normal tissues according to GTEx for SQSTM1 Gene

This gene is overexpressed in Muscle - Skeletal (x4.5).

Protein differential expression in normal tissues from HIPED for SQSTM1 Gene

This gene is overexpressed in Amniocyte (11.8) and Bone (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SQSTM1 Gene



SOURCE GeneReport for Unigene cluster for SQSTM1 Gene Hs.724025

mRNA Expression by UniProt/SwissProt for SQSTM1 Gene

Q13501-SQSTM_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with SQSTM1: view

Protein tissue co-expression partners for SQSTM1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SQSTM1 Gene

Orthologs for SQSTM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SQSTM1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SQSTM1 35
  • 87.2 (n)
  • 92.27 (a)
SQSTM1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sqstm1 35
  • 86.06 (n)
  • 90.23 (a)
Sqstm1 16
Sqstm1 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SQSTM1 35
  • 99.17 (n)
  • 99.77 (a)
SQSTM1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sqstm1 35
  • 85.43 (n)
  • 90.39 (a)
dog
(Canis familiaris)
Mammalia SQSTM1 36
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 64 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SQSTM1 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves SQSTM1 35
  • 68.02 (n)
  • 65.71 (a)
SQSTM1 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SQSTM1 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sqstm1 35
  • 61.42 (n)
  • 57.75 (a)
Str.5660 35
African clawed frog
(Xenopus laevis)
Amphibia MGC64432 35
zebrafish
(Danio rerio)
Actinopterygii lck 35
sqstm1 35
  • 55.48 (n)
  • 53.43 (a)
sqstm1 36
  • 47 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7508 35
Species with no ortholog for SQSTM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SQSTM1 Gene

ENSEMBL:
Gene Tree for SQSTM1 (if available)
TreeFam:
Gene Tree for SQSTM1 (if available)

Paralogs for SQSTM1 Gene

(2) SIMAP similar genes for SQSTM1 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for SQSTM1 Gene

genes like me logo Genes that share paralogs with SQSTM1: view

No data available for Paralogs for SQSTM1 Gene

Variants for SQSTM1 Gene

Sequence variations from dbSNP and Humsavar for SQSTM1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs147810437 - 179,823,906(+) GGAGG(C/T)GCCCC reference, missense
VAR_023591 -
VAR_023592 Frontotemporal dementia and/or amyotrophic lateral sclerosis 3 (FTDALS3)
VAR_023592 Paget disease of bone 3 (PDB3)
rs104893941 Frontotemporal dementia and/or amyotrophic lateral sclerosis 3 (FTDALS3), Paget disease of bone 3 (PDB3) 179,836,445(+) TGACC(C/T)GCGGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SQSTM1 Gene

Variant ID Type Subtype PubMed ID
nsv883270 CNV Loss 21882294
nsv483062 CNV Loss 15286789
nsv469579 CNV Loss 16826518
dgv6400n71 CNV Loss 21882294
nsv883275 CNV Loss 21882294
nsv823361 CNV Loss 20364138
nsv883278 CNV Loss 21882294
dgv6401n71 CNV Loss 21882294
dgv6402n71 CNV Loss 21882294
esv988291 CNV Deletion 20482838

Variation tolerance for SQSTM1 Gene

Residual Variation Intolerance Score: 73.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.74; 46.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SQSTM1 Gene

HapMap Linkage Disequilibrium report
SQSTM1
Human Gene Mutation Database (HGMD)
SQSTM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SQSTM1 Gene

Disorders for SQSTM1 Gene

MalaCards: The human disease database

(26) MalaCards diseases for SQSTM1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
frontotemporal dementia and/or amyotrophic lateral sclerosis 3
  • ftdals3
paget disease of bone 3
  • osteitis deformans
behavioral variant of frontotemporal dementia
  • bv-ftd
paget's disease of bone
  • familial paget's disease of bone
ftdals1
  • frontotemporal dementia and/or amyotrophic lateral sclerosis 1
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

SQSTM_HUMAN
  • Frontotemporal dementia and/or amyotrophic lateral sclerosis 3 (FTDALS3) [MIM:616437]: A neurodegenerative disorder characterized by frontotemporal dementia and/or amyotrophic lateral sclerosis in affected individuals. There is high intrafamilial variation. Frontotemporal dementia is characterized by frontal and temporal lobe atrophy associated with neuronal loss, gliosis, and dementia. Patients exhibit progressive changes in social, behavioral, and/or language function. Amyotrophic lateral sclerosis is characterized by the death of motor neurons in the brain, brainstem, and spinal cord, resulting in fatal paralysis. Some FTDALS3 patients may also develop Paget disease of bone. {ECO:0000269 PubMed:22084127, ECO:0000269 PubMed:24042580, ECO:0000269 PubMed:24899140, ECO:0000269 PubMed:25114083}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=In a cell model for Huntington disease (HD), appears to form a shell surrounding aggregates of mutant HTT that may protect cells from apoptosis, possibly by recruiting autophagosomal components to the polyubiquitinated protein aggregates. {ECO:0000269 PubMed:16286508}.
  • Paget disease of bone 3 (PDB3) [MIM:167250]: A disorder of bone remodeling characterized by increased bone turnover affecting one or more sites throughout the skeleton, primarily the axial skeleton. Osteoclastic overactivity followed by compensatory osteoblastic activity leads to a structurally disorganized mosaic of bone (woven bone), which is mechanically weaker, larger, less compact, more vascular, and more susceptible to fracture than normal adult lamellar bone. {ECO:0000269 PubMed:11992264, ECO:0000269 PubMed:12374763, ECO:0000269 PubMed:14584883, ECO:0000269 PubMed:15125799, ECO:0000269 PubMed:15146436, ECO:0000269 PubMed:15176995, ECO:0000269 PubMed:15207768}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SQSTM1

Genetic Association Database (GAD)
SQSTM1
Human Genome Epidemiology (HuGE) Navigator
SQSTM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SQSTM1
genes like me logo Genes that share disorders with SQSTM1: view

No data available for Genatlas for SQSTM1 Gene

Publications for SQSTM1 Gene

  1. Two novel mutations at exon 8 of the Sequestosome 1 (SQSTM1) gene in an Italian series of patients affected by Paget's disease of bone (PDB). (PMID: 15125799) Falchetti A. … Brandi M.L. (J. Bone Miner. Res. 2004) 3 4 23 48 67
  2. Molecular cloning of a phosphotyrosine-independent ligand of the p56lck SH2 domain. (PMID: 8650207) Joung I. … Shin J. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 23
  3. Dimerisation of the UBA domain of p62 inhibits ubiquitin binding and regulates NF-kappaB signalling. (PMID: 19931284) Long J. … Searle M.S. (J. Mol. Biol. 2010) 3 23
  4. Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation. (PMID: 20103647) Puissant A. … Auberger P. (Cancer Res. 2010) 3 23
  5. SQSTM1 gene analysis and gene-environment interaction in Paget's disease of bone. (PMID: 20200946) Gennari L. … Mossetti G. (J. Bone Miner. Res. 2010) 3 23

Products for SQSTM1 Gene

Sources for SQSTM1 Gene

Back to Top

Content