Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SQSTM1 Gene

protein-coding   GIFtS: 66
GCID: GC05P179234

Sequestosome 1

(Previous names: Paget disease of bone 3, oxidative stress induced like)
(Previous symbols: PDB3, OSIL)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Sequestosome 11 2     A1702
OSIL1 2 3     ZIP32
PDB31 2 5     EBI3-Associated Protein P602
Oxidative Stress Induced Like1 2     p622
Phosphotyrosine-Independent Ligand For The Lck SH2 Domain Of 62 KDa2 3     p62B2
Ubiquitin-Binding Protein P622 3     Phosphotyrosine Independent Ligand For The Lck SH2 Domain P622
EBIAP2 3     sequestosome-12
EBI3-Associated Protein Of 60 KDa2 3     ORCA3
p602 3     P625
Paget Disease Of Bone 31     

External Ids:    HGNC: 112801   Entrez Gene: 88782   Ensembl: ENSG000001610117   OMIM: 6015305   UniProtKB: Q135013   

Export aliases for SQSTM1 gene to outside databases

Previous GC identifers: GC05P179360 GC05P180192 GC05P179297 GC05P179358 GC05P179359 GC05P179181 GC05P173959


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SQSTM1 Gene:
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor
kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF
receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively
spliced transcript variants encoding either the same or different isoforms have been identified for this gene.
Mutations in this gene result in sporadic and familial Paget disease of bone. (provided by RefSeq, Mar 2009)

GeneCards Summary for SQSTM1 Gene:
SQSTM1 (sequestosome 1) is a protein-coding gene. Diseases associated with SQSTM1 include paget's disease of bone, and myotilinopathy. GO annotations related to this gene include protein serine/threonine kinase activity and protein homodimerization activity.

UniProtKB/Swiss-Prot: SQSTM_HUMAN, Q13501
Function: Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called
ALIS (aggresome-like induced structures). Links ALIS to the autophagic machinery via direct interaction with MAP1
LC3 family members. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and
interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades
through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be
involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels

Gene Wiki entry for SQSTM1 (Sequestosome 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the SQSTM1 gene promoter:
         Sp1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): SQSTM1 promoter sequence
   Search Chromatin IP Primers for SQSTM1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SQSTM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35

SQSTM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SQSTM1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P179234:  view genomic region     (about GC identifiers)

Start:
179,233,388 bp from pter      End:
179,265,078 bp from pter
Size:
31,691 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SQSTM_HUMAN, Q13501 (See protein sequence)
Recommended Name: Sequestosome-1  
Size: 440 amino acids; 47687 Da
Subunit: Homooligomer or heterooligomer; may form homotypic arrays. Dimerization interferes with ubiquitin
binding. Interacts directly with PRKCI and PRKCZ (Probable). Forms ternary complexes with PRKCZ and KCNAB2 or
PRKCZ and GABBR3. Also interacts with KCNAB1, GABRR1, GABRR2 and GABRR3. Forms an NGF-induced complex with IKBKB,
PRKCI and TRAF6 (By similarity). Interacts with EBI3, LCK, RASA1, PRKCZ, PRKCI, NR2F2, NTRK1, NTRK2, NTRK3, NBR1,
MAP2K5, TRIM13, TRIM55 and MAPKAPK5. Interacts with the proteasome subunits PSMD4 and PSMC2. Interacts with
K63-polyubiquitinated MAPT/TAU. Interacts with IKBKB through PRKCZ and PRKCI. Interacts with NGFR through TRAF6
and bridges that complex to NTRK1. Forms a complex with MAP2K5 and PRKCZ or PRKCI. Component of a ternary complex
with PAWR and PRKCZ. Upon TNF-alpha stimulation, interacts with RIPK1 problably bridging IKBKB to the TNF-R1
complex composed of TNF-R1/TNFRSF1A, TRADD and RIPK1. Forms a complex with JUB/Ajuba, PRKCZ and TRAF6. Interacts
with TRAF6 and CYLD. Identified in a complex with TRAF6 and CYLD (By similarity). Identified in a heterotrimeric
complex with ubiquitin and ZFAND5, where ZFAND5 and SQSTM1 both interact with the same ubiquitin molecule.
Directly interacts with MAP1LC3A and MAP1LC3B, as well as with other MAP1 LC3 family members, including GABARAP,
GABARAPL1 and GABARAPL2; these interactions are necessary for the recruitment MAP1 LC3 family members to
inclusion bodies containing polyubiquitinated protein aggregates and for their degradation by autophagy.
Interacts with FHOD3. Interacts with TRMI5
5 PDB 3D structures from and Proteopedia for SQSTM1:
1Q02 (3D)        2JY7 (3D)        2JY8 (3D)        2K0B (3D)        2KNV (3D)    
Secondary accessions: A6NFN7 B2R661 B3KUW5 Q13446 Q9BUV7 Q9BVS6 Q9UEU1
Alternative splicing: 2 isoforms:  Q13501-1   Q13501-2   

Explore the universe of human proteins at neXtProt for SQSTM1: NX_Q13501

Explore proteomics data for SQSTM1 at MOPED

Post-translational modifications: 

  • Phosphorylated. May be phosphorylated by PRKCZ (By similarity). Phosphorylated in vitro by TTN1
  • Ubiquitination2 at Lys141, Lys157, Lys165, Lys313, Lys435
  • Modification sites at PhosphoSitePlus

  • See SQSTM1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001135770.1  NP_001135771.1  NP_003891.1  

    ENSEMBL proteins: 
     ENSP00000427308   ENSP00000394534   ENSP00000374455   ENSP00000424195   ENSP00000405061  
     ENSP00000425957   ENSP00000424477   ENSP00000353944   ENSP00000366128   ENSP00000385553  
    Reactome Protein details: Q13501

    SQSTM1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for SQSTM1
    OriGene Purified Protein for SQSTM1
    OriGene Protein Over-expression Lysate for SQSTM1
    OriGene MassSpec for SQSTM1
    OriGene Custom Protein Services for SQSTM1
    GenScript Custom Purified and Recombinant Proteins Services for SQSTM1
    Novus Biologicals SQSTM1 Proteins
    Novus Biologicals SQSTM1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for SQSTM1
    Cloud-Clone Corp. Proteins for SQSTM1

    SQSTM1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SQSTM1
    R&D Systems Antibodies for SQSTM1 (p62/SQSTM1)
    Cell Signaling Technology (CST) Antibodies for SQSTM1 
    OriGene Antibodies for SQSTM1
    OriGene Custom Antibody Services for SQSTM1
    Novus Biologicals SQSTM1 Antibodies
    Abcam antibodies for SQSTM1
    Cloud-Clone Corp. Antibodies for SQSTM1
    ThermoFisher Antibody for SQSTM1
    LSBio Antibodies in human, mouse, rat for SQSTM1

    SQSTM1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SQSTM1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SQSTM1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SQSTM1
    Cloud-Clone Corp. CLIAs for SQSTM1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    4 InterPro protein domains:
     IPR000270 OPR_PB1
     IPR015940 UBA/transl_elong_EF1B_N_euk
     IPR000433 Znf_ZZ
     IPR009060 UBA-like

    Graphical View of Domain Structure for InterPro Entry Q13501

    ProtoNet protein and cluster: Q13501

    2 Blocks protein domains:
    IPB000270 Octicosapeptide/Phox/Bem1p
    IPB000433 Zn-finger


    UniProtKB/Swiss-Prot: SQSTM_HUMAN, Q13501
    Domain: The UBA domain binds specifically 'Lys-63'-linked polyubiquitin chains of polyubiquitinated substrates.
    Mediates the interaction with TRIM55. Both the UBA and OPR domains are necessary and sufficient for the
    localization into the ubiquitin-containing inclusion bodies
    Domain: The OPR domain mediates homooligomerization and interactions with FHOD3, MAP2K5, NBR1, PRKCI and PRKCZ.
    Both the OPR and UBA domains are necessary and sufficient for the localization into the ubiquitin-containing
    inclusion bodies
    Domain: The ZZ-type zinc finger mediates the interaction with RIPK1
    Similarity: Contains 1 OPR domain
    Similarity: Contains 1 UBA domain
    Similarity: Contains 1 ZZ-type zinc finger


    SQSTM1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SQSTM_HUMAN, Q13501
    Function: Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called
    ALIS (aggresome-like induced structures). Links ALIS to the autophagic machinery via direct interaction with MAP1
    LC3 family members. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and
    interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades
    through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be
    involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels
    Induction: By proteasomal inhibitor PSI and prostaglandin J2 (PGJ2) (at protein level). By phorbol 12-myristate
    13-acetate (PMA)

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004674protein serine/threonine kinase activity NAS8618896
    GO:0005080protein kinase C binding IPI14676191
    GO:0005515protein binding IPI14676191
    GO:0008270zinc ion binding IEA--
    GO:0019901protein kinase binding IDA8650207
         
    SQSTM1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SQSTM1:
     Increased cell death HMECs cel  Synthetic lethal with Ras 

         12 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Sqstm1):
     adipose tissue  behavior/neurological  cellular  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 
     nervous system  skeleton 

    SQSTM1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SQSTM1: Sqstm1tm1Keta Sqstm1tm1Jmos Sqstm1tm1Hwl

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SQSTM1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SQSTM1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SQSTM1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SQSTM1

    miRNA
    Products:
        
    miRTarBase miRNAs that target SQSTM1:
    hsa-mir-7-5p (MIRT025851), hsa-mir-423-5p (MIRT038085), hsa-mir-877-5p (MIRT037277), hsa-mir-16-5p (MIRT001410), hsa-mir-484 (MIRT042028), hsa-mir-335-5p (MIRT018399)

    Block miRNA regulation of human, mouse, rat SQSTM1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SQSTM1 (see all 20):
    hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-302e hsa-miR-520a-3p hsa-miR-372 hsa-miR-93 hsa-miR-520d-3p
    SwitchGear 3'UTR luciferase reporter plasmidSQSTM1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SQSTM1
    Predesigned siRNA for gene silencing in human, mouse, rat SQSTM1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SQSTM1

    Clone
    Products:
         
    OriGene clones in human, mouse for SQSTM1 (see all 18)
    OriGene ORF clones in mouse, rat for SQSTM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): SQSTM1 (NM_003900)
    Sino Biological Human cDNA Clone for SQSTM1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SQSTM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SQSTM1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SQSTM1
    Browse ESI BIO Cell Lines and PureStem Progenitors for SQSTM1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SQSTM1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SQSTM_HUMAN, Q13501: Cytoplasm. Late endosome. Lysosome. Cytoplasmic vesicle, autophagosome. Nucleus. Endoplasmic
    reticulum. Cytoplasm, P-body. Note=Sarcomere (By similarity). In cardiac muscles localizes to the sarcomeric band
    (By similarity). Commonly found in inclusion bodies containing polyubiquitinated protein aggregates. In
    neurodegenerative diseases, detected in Lewy bodies in Parkinson disease, neurofibrillary tangles in Alzheimer
    disease, and HTT aggregates in Huntington disease. In protein aggregate diseases of the liver, found in large
    amounts in Mallory bodies of alcoholic and nonalcoholic steatohepatitis, hyaline bodies in hepatocellular
    carcinoma, and in SERPINA1 aggregates. Enriched in Rosenthal fibers of pilocytic astrocytoma. In the cytoplasm,
    observed in both membrane-free ubiquitin-containing protein aggregates (sequestosomes) and membrane-surrounded
    autophagosomes. Colocalizes with TRIM13 in the perinuclear endoplasmic reticulum. Co-localizes with TRIM5 in the
    cytoplasmic bodies
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    endoplasmic reticulum5
    endosome5
    lysosome5
    nucleus5
    vacuole5
    mitochondrion2
    cytoskeleton1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000407pre-autophagosomal structure IEA--
    GO:0000932cytoplasmic mRNA processing body IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005764lysosome IEA--
    GO:0005770late endosome IEA--

    SQSTM1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SQSTM1 About   (see all 18)  
    See pathways by source

    SuperPathContained pathways About
    1Interleukin-1 signaling
    Interleukin-1 signaling0.45
    IL1-mediated signaling events0.45
    2p75 NTR receptor-mediated signalling
    p75 NTR receptor-mediated signalling0.74
    p75NTR signals via NF-kB0.00
    Cell death signalling via NRAGE, NRIF and NADE0.74
    p75NTR recruits signalling complexes0.00
    NF-kB is activated and signals survival0.00
    NRIF signals cell death from the nucleus0.00
    3Signaling by FGFR
    Signalling by NGF0.71
    4Interferon Signaling
    Cytokine Signaling in Immune system0.59
    5Signaling by GPCR
    Signal Transduction0.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Cell Signaling Technology (CST) Pathways for SQSTM1
        Apoptosis and Autophagy
    Translational Control
    Protein Stability

    2 GeneGo (Thomson Reuters) Pathways for SQSTM1
        Signal transduction Activation of PKC via G-Protein coupled receptor
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

    Selected BioSystems Pathways for SQSTM1 (see all 7)
        Senescence and Autophagy
    BDNF signaling pathway
    RANKL/RANK Signaling Pathway
    IL1-mediated signaling events
    p75(NTR)-mediated signaling


    4 Reactome Pathways for SQSTM1
        Interleukin-1 signaling
    p75NTR recruits signalling complexes
    NF-kB is activated and signals survival
    NRIF signals cell death from the nucleus


    1 Kegg Pathway  (Kegg details for SQSTM1):
        Osteoclast differentiation


    SQSTM1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SQSTM1: 
              Oxidative Stress in human mouse rat
              Autophagy in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Cell Death PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SQSTM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SQSTM1 (Q135011, 2, 3 ENSP000003744554) via UniProtKB, MINT, STRING, and/or I2D (see all 1129)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000212866P081072, 3MINT-8378890 MINT-7264704 I2D: score=1 
    ENSG00000215328P081072, 3MINT-8378890 MINT-7264704 I2D: score=1 
    ENSG00000224501P081072, 3MINT-8378890 MINT-7264704 I2D: score=1 
    ENSG00000231555P081072, 3MINT-8378890 MINT-7264704 I2D: score=1 
    ENSG00000232804P081072, 3MINT-8378890 MINT-7264704 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001934positive regulation of protein phosphorylation IEA--
    GO:0002376immune system process IEA--
    GO:0006468protein phosphorylation NAS8618896
    GO:0006511ubiquitin-dependent protein catabolic process TAS8702753
    GO:0006914autophagy TAS19816510

    SQSTM1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SQSTM1 (SQSTM)

    9 Novoseek inferred chemical compound relationships for SQSTM1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 26 1 8618896 (1)
    phosphotyrosine 15 4 8618896 (2), 10714219 (2)
    serine 14.9 2 11078718 (1), 8618896 (1)
    tyrosine 2.83 3 8720131 (1), 10714219 (1), 7545165 (1)
    oxygen 0 1 19524509 (1)
    nadph 0 1 12887891 (1)
    zinc 0 1 19850933 (1)
    potassium 0 1 16085361 (1)
    norepinephrine 0 2 16085361 (2)



    SQSTM1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SQSTM1 gene (3 alternative transcripts): 
    NM_001142298.1  NM_001142299.1  NM_003900.4  

    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000506042 ENST00000514093 ENST00000506690(uc003mkt.1) ENST00000512234
    ENST00000422245 ENST00000481335 ENST00000464493 ENST00000389805(uc003mkw.4 uc003mkx.3)
    ENST00000508284 ENST00000453046 ENST00000504627 ENST00000510187 ENST00000360718
    ENST00000485412 ENST00000466342 ENST00000376929(uc011dgr.2 uc011dgs.2)
    ENST00000402874
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SQSTM1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SQSTM1 (see all 20):
    hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-302e hsa-miR-520a-3p hsa-miR-372 hsa-miR-93 hsa-miR-520d-3p
    SwitchGear 3'UTR luciferase reporter plasmidSQSTM1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SQSTM1
    Predesigned siRNA for gene silencing in human, mouse, rat SQSTM1
    Clone
    Products:
         
    OriGene clones in human, mouse for SQSTM1 (see all 18)
    OriGene ORF clones in mouse, rat for SQSTM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): SQSTM1 (NM_003900)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SQSTM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SQSTM1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SQSTM1
    OriGene qSTAR qPCR primer pairs in human, mouse for SQSTM1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SQSTM1
      QuantiTect SYBR Green Assays in human, mouse, rat SQSTM1
      QuantiFast Probe-based Assays in human, mouse, rat SQSTM1

    Selected AceView cDNA sequences (see all 1474):

    BE041290 CB125609 AW338119 AI887975 BM798362 AW069802 BU858061 T10856 
    BU169463 T34367 BM737693 BQ219609 BG024633 BF448958 AI061084 BE835215 
    BQ943966 BQ019808 CF131616 CF132649 BQ948555 CA416724 BQ953263 BM772707 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SQSTM1 (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11 ^ 12 ^ 13a ·
    SP1:                                            -     -     -           -                                                                                       
    SP2:                                                                                                                                                        -   
    SP3:                                                                                                                                                        -   
    SP4:              -     -     -     -     -     -     -     -           -                                                                                       
    SP5:                    -     -     -     -     -     -     -           -                                                                                       

    ExUns: 13b ^ 14a · 14b ^ 15a · 15b · 15c
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for SQSTM1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SQSTM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGGAGGGT
    SQSTM1 Expression
    About this image


    SQSTM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 25) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 14 entries
             Multinuclear Myocytes Lumbar Back Muscles
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Hippocampus
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Multinuclear Myocytes Forelimb Dorsal Muscles
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Mature Horizontal Cells Inner Nuclear Layer
    SQSTM1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SQSTM1 Protein Expression

    UniProtKB/Swiss-Prot: SQSTM_HUMAN, Q13501
    Tissue specificity: Ubiquitously expressed

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SQSTM1: 
              Oxidative Stress in human mouse rat
              Autophagy in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Cell Death PathwayFinder in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SQSTM1
    OriGene qSTAR qPCR primer pairs in human, mouse for SQSTM1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SQSTM1
    QuantiTect SYBR Green Assays in human, mouse, rat SQSTM1
    QuantiFast Probe-based Assays in human, mouse, rat SQSTM1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SQSTM1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for SQSTM1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sqstm11 , 5 sequestosome 11, 5 86.06(n)1
    90.23(a)1
      11 (30.36 cM)5
    184121  NM_011018.21  NP_035148.11 
     501993665 
    chicken
    (Gallus gallus)
    Aves SQSTM11 sequestosome 1 68.02(n)
    65.71(a)
      770805  XM_001233248.3  XP_001233249.2 
    lizard
    (Anolis carolinensis)
    Reptilia SQSTM16
    sequestosome 1
    49(a)
    1 ↔ 1
    2(140132967-140144553)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC644322 hypothetical protein MGC64432 75.86(n)    BC056852.1 
    zebrafish
    (Danio rerio)
    Actinopterygii lck2 lck 76.47(n)   30099  CD759371.1 


    ENSEMBL Gene Tree for SQSTM1 (if available)
    TreeFam Gene Tree for SQSTM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SQSTM1 gene
    2 SIMAP similar genes for SQSTM1 using alignment to 7 protein entries:     SQSTM_HUMAN (see all proteins):
    SQSTM1-ALK    OSIL

    SQSTM1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for SQSTM1
    PGOHUM00000248416 PGOHUM00000248617


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SQSTM1 (see all 857)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1048939411,2,,4
    C,FPaget disease of bone (PDB)4 pathogenic1179263445(+) TGACCC/TGCGGC 6 P L mis12Minor allele frequency- T:0.00NA EU 5871
    VAR_0235984
    Paget disease of bone (PDB)4--see VAR_0235982 G R mis40--------
    VAR_0235944
    Paget disease of bone (PDB)4--see VAR_0235942 S P mis40--------
    VAR_0235954
    Paget disease of bone (PDB)4--see VAR_0235952 M T mis40--------
    VAR_0235964
    Paget disease of bone (PDB)4--see VAR_0235962 M V mis40--------
    VAR_0235974
    Paget disease of bone (PDB)4--see VAR_0235972 G S mis40--------
    VAR_0235924
    Paget disease of bone (PDB)4--see VAR_0235922 P L mis40--------
    rs1928321351,2
    --179236018(+) ACGCTC/TGGCTG 2 -- int10--------
    rs1852151091,2
    --179236232(+) CGGCTC/TACTGC 2 -- int10--------
    rs710010491,2
    C--179236326(+) TTTTTT/-GAGAC 2 -- int11Minor allele frequency- -:0.00NA 2

    HapMap Linkage Disequilibrium report for SQSTM1 (179233388 - 179265078 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for SQSTM1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv988291CNV Deletion20482838
    nsv823361CNV Loss20364138
    nsv883270CNV Loss21882294
    nsv469579CNV Loss16826518
    nsv883278CNV Loss21882294
    nsv483062CNV Loss15286789
    dgv6401n71CNV Loss21882294
    dgv6402n71CNV Loss21882294
    nsv883275CNV Loss21882294
    dgv6400n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): SQSTM1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SQSTM1
    DNA2.0 Custom Variant and Variant Library Synthesis for SQSTM1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 601530   
    OMIM disorders: 602080  
    UniProtKB/Swiss-Prot: SQSTM_HUMAN, Q13501
  • Paget disease of bone (PDB) [MIM:602080]: Metabolic bone disease affecting the axial skeleton and
    characterized by focal areas of increased and disorganized bone turn-over due to activated osteoclasts.
    Manifestations of the disease include bone pain, deformity, pathological fractures, deafness, neurological
    complications and increased risk of osteosarcoma. PDB is a chronic disease affecting 2 to 3% of the population
    above the age of 40 years. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Note=In a cell model for Huntington disease (HD), appears to form a shell surrounding aggregates of
    mutant HTT that may protect cells from apoptosis, possibly by recruiting autophagosomal components to the
    polyubiquitinylated protein aggregates

  • Selected diseases for SQSTM1 (see all 66):    
    About MalaCards
    paget's disease of bone    myotilinopathy    mycobacterium abscessus    mammary paget's disease
    frontotemporal lobar degeneration with ubiquitin-positive inclusions    nephropathic cystinosis    multiple system atrophy    amyotrophic lateral sclerosis
    spinal-bulbar muscular atrophy    benign meningioma    motor neuron disease    frontotemporal dementia
    periostitis    cystinosis    nonalcoholic steatohepatitis    pick's disease
    inclusion body myositis    dementia    tauopathy    pilocytic astrocytoma

    3 diseases from the University of Copenhagen DISEASES database for SQSTM1:
    Paget's disease of bone     Mammary Paget's disease     Frontotemporal dementia

    SQSTM1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for SQSTM1 gene (see all 25)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    familial expansile osteolysis 73.1 1 17284635 (1)
    frontotemporal dementia 73.1 1 18379439 (1)
    picks disease 63.7 1 11447312 (1)
    motor neuron disease 59 2 18992722 (1), 18379439 (1)
    neurodegenerative diseases 52 7 16820172 (1), 19200883 (1), 14762676 (1), 19557423 (1) (see all 6)
    amyotrophic lateral sclerosis 48.5 2 16820172 (1), 14762676 (1)
    paired helical filament 47.6 1 11447312 (1)
    neurofibrillary tangles 42 4 14762676 (1), 19557423 (1), 11786419 (1)
    hepatocellular carcinoma 40.9 15 14613989 (2), 14514377 (2), 11549587 (1), 15886058 (1) (see all 8)
    hepatitis alcoholic 39.1 1 15964033 (1)

    Genetic Association Database (GAD): SQSTM1
    Human Genome Epidemiology (HuGE) Navigator: SQSTM1 (13 documents)

    Export disorders for SQSTM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SQSTM1 gene, integrated from 10 sources (see all 382):
    (articles sorted by number of sources associating them with SQSTM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two novel mutations at exon 8 of the Sequestosome 1 (SQSTM1) gene in an Italian series of patients affected by Paget's disease of bone (PDB). (PubMed id 15125799)1, 2, 4, 9 Falchetti A.... Brandi M.L. (J. Bone Miner. Res. 2004)
    2. Molecular cloning of a phosphotyrosine-independent ligand of the p56lck SH2 domain. (PubMed id 8650207)1, 2, 3, 9 Joung I.... Shin J. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    3. A novel interleukin-12 p40-related protein induced by latent Epstein- Barr virus infection in B lymphocytes. (PubMed id 8551575)1, 2, 3 Devergne O.... Birkenbach M. (J. Virol. 1996)
    4. Three novel mutations in SQSTM1 identified in familial Paget's disease of bone. (PubMed id 14584883)1, 2, 9 Johnson-Pais T.L.... Leach R.J. (J. Bone Miner. Res. 2003)
    5. p62 overexpression in breast tumors and regulation by prostate- derived Ets factor in breast cancer cells. (PubMed id 12700667)1, 2, 9 Thompson H.G.R.... Brody J.P. (Oncogene 2003)
    6. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. (PubMed id 16286508)1, 2, 9 Bjorkoy G.... Johansen T. (J. Cell Biol. 2005)
    7. Transcriptional activation of p62/A170/ZIP during the formation of the aggregates: possible mechanisms and the role in Lewy body formation in Parkinson's disease. (PubMed id 15158159)1, 2, 9 Nakaso K.... Nakashima K. (Brain Res. 2004)
    8. Structure of the ubiquitin-associated domain of p62 (SQSTM1) and implications for mutations that cause Paget's disease of bone. (PubMed id 12857745)1, 2, 9 Ciani B.... Searle M.S. (J. Biol. Chem. 2003)
    9. The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation. (PubMed id 10356400)1, 2, 9 Sanz L.... Moscat J. (EMBO J. 1999)
    10. SQSTM1 gene analysis and gene-environment interaction in Paget's disease of bone. (PubMed id 20200946)1, 4, 9 Gennari L....Mossetti G. (J. Bone Miner. Res. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 8878 HGNC: 11280 AceView: SQSTM1 Ensembl:ENSG00000161011 euGenes: HUgn8878
    ECgene: SQSTM1 Kegg: 8878 H-InvDB: SQSTM1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SQSTM1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SQSTM1 gene:
    Search GeneIP for patents involving SQSTM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of SQSTM1
     
     EMD Millipore genomic analysis products

      
     Antibodies for SQSTM1 (p62/SQSTM1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SQSTM1   OriGene RNAi products in human, mouse, rat for SQSTM1  
     OriGene qPCR primer pairs and template standards for SQSTM1   OriGene Protein Over-expression Lysate for SQSTM1  
     OriGene MassSpec something-or-other for SQSTM1   OriGene clones in human, mouse for SQSTM1  
     OriGene qSTAR qPCR primer pairs in human, mouse for SQSTM1   OriGene Purified Protein for SQSTM1  
     OriGene ORF clones in mouse, rat for SQSTM1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SQSTM1   OriGene Custom Protein Services for SQSTM1  

     
     
     Block miRNA regulation of human, mouse, rat SQSTM1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SQSTM1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SQSTM1 Predesigned siRNA for gene silencing in human, mouse, rat SQSTM1
     QuantiFast Probe-based Assays in human, mouse, rat SQSTM1 QuantiTect SYBR Green Assays in human, mouse, rat SQSTM1
     PCR Arrays including human, mouse, rat SQSTM1 Search Chromatin IP Primers for SQSTM1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SQSTM1  GeneGlobe Interaction Network for SQSTM1
     Regulatory tfbs in SQSTM1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SQSTM1 GenScript cDNA clones with any tag delivered in your preferred vector for SQSTM1
     GenScript Custom Assay Services for SQSTM1 GenScript Custom overexpressing Cell Line Services for SQSTM1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for SQSTM1 

     Search Tocris compounds for SQSTM1 (SQSTM)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for SQSTM1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for SQSTM1
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SQSTM1 antibodies
     SQSTM1 proteins
     SQSTM1 lysates
     Antibodies for SQSTM1
     See all of Abcam's Antibodies, Kits and Proteins for SQSTM1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for SQSTM1
     Proteins for SQSTM1
     Antibodies for SQSTM1
     ELISAs for SQSTM1
     CLIAs for SQSTM1



     Browse ESI BIO Cell Lines and PureStem Progenitors for SQSTM1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SQSTM1
     SwitchGear 3'UTR luciferase reporter plasmids for SQSTM1
     SwitchGear Promoter luciferase reporter plasmids for SQSTM1
     ThermoFisher Antibody for SQSTM1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SQSTM1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SQSTM1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SQSTM1
     LSBio Antibodies in human, mouse, rat for SQSTM1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SQSTM1 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4