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Aliases for SQRDL Gene

Aliases for SQRDL Gene

  • Sulfide Quinone Reductase-Like (Yeast) 2 3 5
  • SQOR 3 4
  • Sulfide:Quinone Oxidoreductase, Mitochondrial 3
  • Sulfide Dehydrogenase Like 3
  • EC 1.8.5.- 4
  • PRO1975 3
  • CGI-44 3

External Ids for SQRDL Gene

Previous GeneCards Identifiers for SQRDL Gene

  • GC15P041484
  • GC15P038973
  • GC15P043459
  • GC15P043643
  • GC15P043617
  • GC15P043714
  • GC15P045927
  • GC15P022749

Summaries for SQRDL Gene

Entrez Gene Summary for SQRDL Gene

  • The protein encoded by this gene may function in mitochondria to catalyze the conversion of sulfide to persulfides, thereby decreasing toxic concencrations of sulfide. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2012]

GeneCards Summary for SQRDL Gene

SQRDL (Sulfide Quinone Reductase-Like (Yeast)) is a Protein Coding gene. Among its related pathways are Metabolism and Sulfur amino acid metabolism. GO annotations related to this gene include oxidoreductase activity and sulfide:quinone oxidoreductase activity. An important paralog of this gene is ENSG00000260170.

UniProtKB/Swiss-Prot for SQRDL Gene

  • Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SQRDL Gene

Genomics for SQRDL Gene

Regulatory Elements for SQRDL Gene

Enhancers for SQRDL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F045636 1.4 FANTOM5 ENCODE 24.4 +8.8 8776 6.7 PKNOX1 WRNIP1 ARID4B FEZF1 DMAP1 YY1 FOS MIER2 TBX21 PPARG C15orf48 SQRDL BLOC1S6 ENSG00000259539 LOC100533853 SPATA5L1 SHF GC15P045696
GH15F045585 1.1 ENCODE 16.2 -43.4 -43374 4.3 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 SQRDL SLC30A4 ENSG00000259539 GC15P045592 ENSG00000260170
GH15F045454 1.5 FANTOM5 ENCODE 10.6 -174.7 -174660 4.4 ATF1 SIN3A FEZF1 GLI4 BRCA1 ZNF143 FOS SP3 ZHX2 JUNB C15orf48 LOC100533853 SPATA5L1 MIR147B SLC30A4 SQRDL BLOC1S6 GC15P045452 GC15M045480
GH15F044733 1.2 Ensembl ENCODE 10.8 -895.3 -895288 4.1 YBX3 HDGF HDAC1 ATF1 CBX3 TBL1XR1 YBX1 RAD21 YY1 ZNF366 TRIM69 SQRDL GC15P044732 ENSG00000276121
GH15F045444 1.5 FANTOM5 Ensembl ENCODE 8 -185.0 -184998 2.8 KLF1 MAX CEBPG ZIC2 SMC3 SMARCC2 PRDM10 E2F6 CHD2 ZNF263 C15orf48 BLOC1S6 EIF3J-AS1 HNRNPMP1 SQRDL ENSG00000259539 LOC100533853 SPATA5L1 GC15M045447 GC15P045444
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SQRDL on UCSC Golden Path with GeneCards custom track

Genomic Location for SQRDL Gene

Chromosome:
15
Start:
45,631,148 bp from pter
End:
45,691,294 bp from pter
Size:
60,147 bases
Orientation:
Plus strand

Genomic View for SQRDL Gene

Genes around SQRDL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SQRDL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SQRDL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SQRDL Gene

Proteins for SQRDL Gene

  • Protein details for SQRDL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6N5-SQRD_HUMAN
    Recommended name:
    Sulfide:quinone oxidoreductase, mitochondrial
    Protein Accession:
    Q9Y6N5
    Secondary Accessions:
    • Q9UQM8

    Protein attributes for SQRDL Gene

    Size:
    450 amino acids
    Molecular mass:
    49961 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available

neXtProt entry for SQRDL Gene

Post-translational modifications for SQRDL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SQRDL Gene

Domains & Families for SQRDL Gene

Protein Domains for SQRDL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SQRDL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6N5

UniProtKB/Swiss-Prot:

SQRD_HUMAN :
  • Belongs to the SQRD family.
Family:
  • Belongs to the SQRD family.
genes like me logo Genes that share domains with SQRDL: view

No data available for Gene Families for SQRDL Gene

Function for SQRDL Gene

Molecular function for SQRDL Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro).

Enzyme Numbers (IUBMB) for SQRDL Gene

Gene Ontology (GO) - Molecular Function for SQRDL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
GO:0048038 quinone binding IEA --
GO:0070224 sulfide:quinone oxidoreductase activity IDA 22852582
genes like me logo Genes that share ontologies with SQRDL: view
genes like me logo Genes that share phenotypes with SQRDL: view

Animal Model Products

miRNA for SQRDL Gene

miRTarBase miRNAs that target SQRDL

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SQRDL Gene

Localization for SQRDL Gene

Subcellular locations from UniProtKB/Swiss-Prot for SQRDL Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SQRDL gene
Compartment Confidence
mitochondrion 5
cytosol 2
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SQRDL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane TAS --
genes like me logo Genes that share ontologies with SQRDL: view

Pathways & Interactions for SQRDL Gene

genes like me logo Genes that share pathways with SQRDL: view

Gene Ontology (GO) - Biological Process for SQRDL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
GO:0070221 sulfide oxidation, using sulfide:quinone oxidoreductase TAS --
GO:0070813 hydrogen sulfide metabolic process IDA 22852582
genes like me logo Genes that share ontologies with SQRDL: view

No data available for SIGNOR curated interactions for SQRDL Gene

Drugs & Compounds for SQRDL Gene

(1) Drugs for SQRDL Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
genes like me logo Genes that share compounds with SQRDL: view

Transcripts for SQRDL Gene

Unigene Clusters for SQRDL Gene

Sulfide quinone reductase-like (yeast):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SQRDL Gene

No ASD Table

Relevant External Links for SQRDL Gene

GeneLoc Exon Structure for
SQRDL
ECgene alternative splicing isoforms for
SQRDL

Expression for SQRDL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SQRDL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SQRDL Gene

This gene is overexpressed in Whole Blood (x7.1) and Colon - Transverse (x5.3).

Protein differential expression in normal tissues from HIPED for SQRDL Gene

This gene is overexpressed in Nasal epithelium (31.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SQRDL Gene



Protein tissue co-expression partners for SQRDL Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SQRDL Gene:

SQRDL

SOURCE GeneReport for Unigene cluster for SQRDL Gene:

Hs.511251
genes like me logo Genes that share expression patterns with SQRDL: view

No data available for mRNA Expression by UniProt/SwissProt for SQRDL Gene

Orthologs for SQRDL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SQRDL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SQRDL 34 35
  • 98.89 (n)
dog
(Canis familiaris)
Mammalia SQRDL 34 35
  • 89.04 (n)
cow
(Bos Taurus)
Mammalia SQRDL 34 35
  • 88.15 (n)
rat
(Rattus norvegicus)
Mammalia Sqrdl 34
  • 84.52 (n)
mouse
(Mus musculus)
Mammalia Sqrdl 34 16 35
  • 83.11 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 80 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 75 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 78 (a)
OneToMany
SQRDL 34
  • 73.96 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 78 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia sqrdl 34
  • 70.66 (n)
Str.1787 34
African clawed frog
(Xenopus laevis)
Amphibia sqrdl-prov 34
zebrafish
(Danio rerio)
Actinopterygii sqrdl 34 35
  • 69.45 (n)
wufj81h04 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4140 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003142 34
  • 57.25 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14997 36 34 35
  • 56.97 (n)
worm
(Caenorhabditis elegans)
Secernentea sqrd-1 34 35
  • 52.23 (n)
Y9C9A.16 36 35
  • 43 (a)
F02H6.5 36
  • 40 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07112 34
  • 51.35 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes hmt2 34
  • 50 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 50 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11119 34
Species where no ortholog for SQRDL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SQRDL Gene

ENSEMBL:
Gene Tree for SQRDL (if available)
TreeFam:
Gene Tree for SQRDL (if available)

Paralogs for SQRDL Gene

Paralogs for SQRDL Gene

genes like me logo Genes that share paralogs with SQRDL: view

Variants for SQRDL Gene

Sequence variations from dbSNP and Humsavar for SQRDL Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10083609 -- 45,684,128(+) ggctg(G/T)tctcg intron-variant
rs1017518 -- 45,641,109(+) CATAT(A/T)TTTTC intron-variant
rs1044032 -- 45,676,237(+) CCTCA(C/T)TGAAG reference, missense
rs1044099 -- 45,691,065(+) GGCTT(C/T)TGGGC utr-variant-3-prime
rs10519033 -- 45,681,728(+) CAAAA(C/T)GTGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SQRDL Gene

Variant ID Type Subtype PubMed ID
nsv952619 CNV duplication 24416366
nsv526945 CNV gain 19592680
nsv1160292 CNV duplication 26073780
esv3892684 CNV gain 25118596
esv3569553 CNV gain 25503493
esv3361444 CNV duplication 20981092
esv274920 OTHER complex 21479260
esv23356 CNV gain 19812545
dgv1204n106 CNV deletion 24896259

Variation tolerance for SQRDL Gene

Residual Variation Intolerance Score: 37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.52; 29.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SQRDL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SQRDL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SQRDL Gene

Disorders for SQRDL Gene

Relevant External Links for SQRDL

Genetic Association Database (GAD)
SQRDL
Human Genome Epidemiology (HuGE) Navigator
SQRDL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SQRDL

No disorders were found for SQRDL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SQRDL Gene

Publications for SQRDL Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 64
  2. A fission yeast gene for mitochondrial sulfide oxidation. (PMID: 10224084) Vande Weghe J.G. … Ow D.W. (J. Biol. Chem. 1999) 2 3 4 64
  3. Human sulfide:quinone oxidoreductase catalyzes the first step in hydrogen sulfide metabolism and produces a sulfane sulfur metabolite. (PMID: 22852582) Jackson M.R. … Jorns M.S. (Biochemistry 2012) 3 4 64
  4. Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women. (PMID: 20966902) Croteau-Chonka D.C. … Mohlke K.L. (Obesity (Silver Spring) 2011) 3 46 64
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64

Products for SQRDL Gene

Sources for SQRDL Gene

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