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Aliases for SQRDL Gene

Aliases for SQRDL Gene

  • Sulfide Quinone Reductase-Like (Yeast) 2 3
  • SQOR 3 4
  • Sulfide:Quinone Oxidoreductase, Mitochondrial 3
  • Sulfide Dehydrogenase Like 3
  • EC 1.8.5.- 4
  • PRO1975 3
  • CGI-44 3

External Ids for SQRDL Gene

Previous GeneCards Identifiers for SQRDL Gene

  • GC15P041484
  • GC15P038973
  • GC15P043459
  • GC15P043643
  • GC15P043617
  • GC15P043714
  • GC15P045927
  • GC15P022749

Summaries for SQRDL Gene

Entrez Gene Summary for SQRDL Gene

  • The protein encoded by this gene may function in mitochondria to catalyze the conversion of sulfide to persulfides, thereby decreasing toxic concencrations of sulfide. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2012]

GeneCards Summary for SQRDL Gene

SQRDL (Sulfide Quinone Reductase-Like (Yeast)) is a Protein Coding gene. Diseases associated with SQRDL include ethylmalonic encephalopathy. Among its related pathways are Metabolism and Metabolism of amino acids and derivatives. GO annotations related to this gene include sulfide:quinone oxidoreductase activity. An important paralog of this gene is ENSG00000260170.

UniProtKB/Swiss-Prot for SQRDL Gene

  • Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SQRDL Gene

Genomics for SQRDL Gene

Regulatory Elements for SQRDL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SQRDL Gene

Start:
45,631,148 bp from pter
End:
45,691,294 bp from pter
Size:
60,147 bases
Orientation:
Plus strand

Genomic View for SQRDL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SQRDL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SQRDL Gene

Proteins for SQRDL Gene

  • Protein details for SQRDL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6N5-SQRD_HUMAN
    Recommended name:
    Sulfide:quinone oxidoreductase, mitochondrial
    Protein Accession:
    Q9Y6N5
    Secondary Accessions:
    • Q9UQM8

    Protein attributes for SQRDL Gene

    Size:
    450 amino acids
    Molecular mass:
    49961 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692; Note=Binds 1 FAD per subunit.;
    Quaternary structure:
    No Data Available

neXtProt entry for SQRDL Gene

Proteomics data for SQRDL Gene at MOPED

Post-translational modifications for SQRDL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SQRDL Gene

No data available for DME Specific Peptides for SQRDL Gene

Domains for SQRDL Gene

Protein Domains for SQRDL Gene

Suggested Antigen Peptide Sequences for SQRDL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6N5

UniProtKB/Swiss-Prot:

SQRD_HUMAN :
  • Q9Y6N5
Family:
  • Belongs to the SQRD family.
genes like me logo Genes that share domains with SQRDL: view

No data available for Gene Families for SQRDL Gene

Function for SQRDL Gene

Molecular function for SQRDL Gene

UniProtKB/Swiss-Prot Function: Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro).

Enzyme Numbers (IUBMB) for SQRDL Gene

Gene Ontology (GO) - Molecular Function for SQRDL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity --
GO:0048038 quinone binding IEA --
GO:0070224 sulfide:quinone oxidoreductase activity IDA 22852582
genes like me logo Genes that share ontologies with SQRDL: view

Phenotypes for SQRDL Gene

genes like me logo Genes that share phenotypes with SQRDL: view

Animal Model Products

CRISPR Products

miRNA for SQRDL Gene

miRTarBase miRNAs that target SQRDL

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SQRDL

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for SQRDL Gene

Localization for SQRDL Gene

Subcellular locations from UniProtKB/Swiss-Prot for SQRDL Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SQRDL Gene COMPARTMENTS Subcellular localization image for SQRDL gene
Compartment Confidence
mitochondrion 4
cytosol 3
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SQRDL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane TAS --
genes like me logo Genes that share ontologies with SQRDL: view

Pathways for SQRDL Gene

genes like me logo Genes that share pathways with SQRDL: view

Gene Ontology (GO) - Biological Process for SQRDL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000096 sulfur amino acid metabolic process TAS --
GO:0000098 sulfur amino acid catabolic process TAS --
GO:0034641 cellular nitrogen compound metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0055114 oxidation-reduction process --
genes like me logo Genes that share ontologies with SQRDL: view

Compounds for SQRDL Gene

(1) HMDB Compounds for SQRDL Gene

Compound Synonyms Cas Number PubMed IDs
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
genes like me logo Genes that share compounds with SQRDL: view

Transcripts for SQRDL Gene

Unigene Clusters for SQRDL Gene

Sulfide quinone reductase-like (yeast):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SQRDL

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SQRDL Gene

No ASD Table

Relevant External Links for SQRDL Gene

GeneLoc Exon Structure for
SQRDL
ECgene alternative splicing isoforms for
SQRDL

Expression for SQRDL Gene

mRNA expression in normal human tissues for SQRDL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SQRDL Gene

This gene is overexpressed in Whole Blood (7.1) and Colon - Transverse (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SQRDL Gene

SOURCE GeneReport for Unigene cluster for SQRDL Gene Hs.511251

genes like me logo Genes that share expressions with SQRDL: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SQRDL Gene

Orthologs for SQRDL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SQRDL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SQRDL 35
  • 98.89 (n)
  • 98.67 (a)
SQRDL 36
  • 99 (a)
OneToMany
cow
(Bos Taurus)
Mammalia SQRDL 35
  • 88.15 (n)
  • 91.33 (a)
SQRDL 36
  • 87 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SQRDL 35
  • 89.04 (n)
  • 91.78 (a)
SQRDL 36
  • 92 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Sqrdl 35
  • 83.11 (n)
  • 86.89 (a)
Sqrdl 16
Sqrdl 36
  • 87 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 80 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 75 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Sqrdl 35
  • 84.52 (n)
  • 89.78 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 78 (a)
OneToMany
SQRDL 35
  • 73.96 (n)
  • 79.95 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 78 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia sqrdl-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia sqrdl 35
  • 70.66 (n)
  • 74.43 (a)
Str.1787 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4140 35
zebrafish
(Danio rerio)
Actinopterygii sqrdl 35
  • 69.45 (n)
  • 75.42 (a)
sqrdl 36
  • 66 (a)
OneToMany
wufj81h04 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003142 35
  • 57.25 (n)
  • 53.32 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14997 35
  • 56.97 (n)
  • 51.68 (a)
CG14997 36
  • 47 (a)
OneToMany
CG14997 37
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea sqrd-1 35
  • 52.23 (n)
  • 46.04 (a)
sqrd-1 36
  • 39 (a)
ManyToMany
Y9C9A.16 36
  • 43 (a)
ManyToMany
F02H6.5 37
  • 40 (a)
Y9C9A.16 37
  • 43 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07112 35
  • 51.35 (n)
  • 42.38 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes hmt2 35
  • 50 (n)
  • 41.95 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11119 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToMany
Species with no ortholog for SQRDL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SQRDL Gene

ENSEMBL:
Gene Tree for SQRDL (if available)
TreeFam:
Gene Tree for SQRDL (if available)

Paralogs for SQRDL Gene

Paralogs for SQRDL Gene

genes like me logo Genes that share paralogs with SQRDL: view

Variants for SQRDL Gene

Sequence variations from dbSNP and Humsavar for SQRDL Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs10643 -- 45,689,119(+) GAGCC(A/G)CTAGA synonymous-codon, reference
rs11633 -- 45,691,256(-) GAAAG(A/G)TAAAA utr-variant-3-prime
rs187095 -- 45,629,832(+) GTGAT(C/G)TGCCT upstream-variant-2KB
rs187096 -- 45,671,413(-) tgaga(A/G)gctga intron-variant
rs191614 -- 45,688,749(+) CTCAG(A/G)TGATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SQRDL Gene

Variant ID Type Subtype PubMed ID
nsv904188 CNV Gain 21882294
dgv2379n71 CNV Gain 21882294
nsv904190 CNV Gain 21882294
nsv526945 CNV Gain 19592680
esv274920 CNV Complex 21479260
esv23356 CNV Gain 19812545

Relevant External Links for SQRDL Gene

HapMap Linkage Disequilibrium report
SQRDL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SQRDL Gene

Disorders for SQRDL Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SQRDL Gene including...

Search for SQRDL Gene in MalaCards »

Relevant External Links for SQRDL

Genetic Association Database (GAD)
SQRDL
Human Genome Epidemiology (HuGE) Navigator
SQRDL
genes like me logo Genes that share disorders with SQRDL: view

No data available for UniProtKB/Swiss-Prot for SQRDL Gene

Publications for SQRDL Gene

  1. A fission yeast gene for mitochondrial sulfide oxidation. (PMID: 10224084) Vande Weghe J.G. … Ow D.W. (J. Biol. Chem. 1999) 2 3 4
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  4. Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women. (PMID: 20966902) Croteau-Chonka D.C. … Mohlke K.L. (Obesity (Silver Spring) 2011) 3 48
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SQRDL Gene

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