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Aliases for SQRDL Gene

Aliases for SQRDL Gene

  • Sulfide Quinone Reductase-Like (Yeast) 2 3 5
  • SQOR 3 4
  • Sulfide:Quinone Oxidoreductase, Mitochondrial 3
  • Sulfide Dehydrogenase Like 3
  • EC 1.8.5.- 4
  • PRO1975 3
  • CGI-44 3

External Ids for SQRDL Gene

Previous GeneCards Identifiers for SQRDL Gene

  • GC15P041484
  • GC15P038973
  • GC15P043459
  • GC15P043643
  • GC15P043617
  • GC15P043714
  • GC15P045927
  • GC15P022749

Summaries for SQRDL Gene

Entrez Gene Summary for SQRDL Gene

  • The protein encoded by this gene may function in mitochondria to catalyze the conversion of sulfide to persulfides, thereby decreasing toxic concencrations of sulfide. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2012]

GeneCards Summary for SQRDL Gene

SQRDL (Sulfide Quinone Reductase-Like (Yeast)) is a Protein Coding gene. Diseases associated with SQRDL include Ethylmalonic Encephalopathy. Among its related pathways are Sulfur amino acid metabolism and Sulfur metabolism. GO annotations related to this gene include oxidoreductase activity and sulfide:quinone oxidoreductase activity. An important paralog of this gene is ENSG00000260170.

UniProtKB/Swiss-Prot for SQRDL Gene

  • Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SQRDL Gene

Genomics for SQRDL Gene

Regulatory Elements for SQRDL Gene

Enhancers for SQRDL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SQRDL on UCSC Golden Path with GeneCards custom track

Genomic Location for SQRDL Gene

Chromosome:
15
Start:
45,631,148 bp from pter
End:
45,691,294 bp from pter
Size:
60,147 bases
Orientation:
Plus strand

Genomic View for SQRDL Gene

Genes around SQRDL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SQRDL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SQRDL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SQRDL Gene

Proteins for SQRDL Gene

  • Protein details for SQRDL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6N5-SQRD_HUMAN
    Recommended name:
    Sulfide:quinone oxidoreductase, mitochondrial
    Protein Accession:
    Q9Y6N5
    Secondary Accessions:
    • Q9UQM8

    Protein attributes for SQRDL Gene

    Size:
    450 amino acids
    Molecular mass:
    49961 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available

neXtProt entry for SQRDL Gene

Post-translational modifications for SQRDL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SQRDL Gene

Domains & Families for SQRDL Gene

Protein Domains for SQRDL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SQRDL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6N5

UniProtKB/Swiss-Prot:

SQRD_HUMAN :
  • Belongs to the SQRD family.
Family:
  • Belongs to the SQRD family.
genes like me logo Genes that share domains with SQRDL: view

No data available for Gene Families for SQRDL Gene

Function for SQRDL Gene

Molecular function for SQRDL Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro).

Enzyme Numbers (IUBMB) for SQRDL Gene

Gene Ontology (GO) - Molecular Function for SQRDL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048038 quinone binding IEA --
GO:0070224 sulfide:quinone oxidoreductase activity IDA 22852582
genes like me logo Genes that share ontologies with SQRDL: view
genes like me logo Genes that share phenotypes with SQRDL: view

Animal Model Products

CRISPR Products

miRNA for SQRDL Gene

miRTarBase miRNAs that target SQRDL

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SQRDL Gene

Localization for SQRDL Gene

Subcellular locations from UniProtKB/Swiss-Prot for SQRDL Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SQRDL Gene COMPARTMENTS Subcellular localization image for SQRDL gene
Compartment Confidence
mitochondrion 5
cytosol 2
endoplasmic reticulum 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SQRDL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane TAS --
genes like me logo Genes that share ontologies with SQRDL: view

Pathways & Interactions for SQRDL Gene

genes like me logo Genes that share pathways with SQRDL: view

Gene Ontology (GO) - Biological Process for SQRDL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070221 sulfide oxidation, using sulfide:quinone oxidoreductase TAS --
GO:0070813 hydrogen sulfide metabolic process IDA 22852582
genes like me logo Genes that share ontologies with SQRDL: view

No data available for SIGNOR curated interactions for SQRDL Gene

Drugs & Compounds for SQRDL Gene

(1) Drugs for SQRDL Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
genes like me logo Genes that share compounds with SQRDL: view

Transcripts for SQRDL Gene

Unigene Clusters for SQRDL Gene

Sulfide quinone reductase-like (yeast):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SQRDL Gene

No ASD Table

Relevant External Links for SQRDL Gene

GeneLoc Exon Structure for
SQRDL
ECgene alternative splicing isoforms for
SQRDL

Expression for SQRDL Gene

mRNA expression in normal human tissues for SQRDL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SQRDL Gene

This gene is overexpressed in Whole Blood (x7.1) and Colon - Transverse (x5.3).

Protein differential expression in normal tissues from HIPED for SQRDL Gene

This gene is overexpressed in Nasal epithelium (31.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SQRDL Gene



Protein tissue co-expression partners for SQRDL Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SQRDL Gene:

SQRDL

SOURCE GeneReport for Unigene cluster for SQRDL Gene:

Hs.511251
genes like me logo Genes that share expression patterns with SQRDL: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SQRDL Gene

Orthologs for SQRDL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SQRDL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SQRDL 34
  • 88.15 (n)
  • 91.33 (a)
SQRDL 35
  • 87 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SQRDL 34
  • 89.04 (n)
  • 91.78 (a)
SQRDL 35
  • 92 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Sqrdl 34
  • 83.11 (n)
  • 86.89 (a)
Sqrdl 16
Sqrdl 35
  • 87 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia SQRDL 34
  • 98.89 (n)
  • 98.67 (a)
SQRDL 35
  • 99 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Sqrdl 34
  • 84.52 (n)
  • 89.78 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 80 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 75 (a)
OneToMany
chicken
(Gallus gallus)
Aves SQRDL 34
  • 73.96 (n)
  • 79.95 (a)
-- 35
  • 78 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 78 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia sqrdl 34
  • 70.66 (n)
  • 74.43 (a)
Str.1787 34
African clawed frog
(Xenopus laevis)
Amphibia sqrdl-prov 34
zebrafish
(Danio rerio)
Actinopterygii sqrdl 34
  • 69.45 (n)
  • 75.42 (a)
wufj81h04 34
sqrdl 35
  • 66 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4140 34
fruit fly
(Drosophila melanogaster)
Insecta CG14997 36
  • 51 (a)
CG14997 34
  • 56.97 (n)
  • 51.68 (a)
CG14997 35
  • 47 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003142 34
  • 57.25 (n)
  • 53.32 (a)
worm
(Caenorhabditis elegans)
Secernentea F02H6.5 36
  • 40 (a)
Y9C9A.16 36
  • 43 (a)
sqrd-1 34
  • 52.23 (n)
  • 46.04 (a)
sqrd-1 35
  • 39 (a)
ManyToMany
Y9C9A.16 35
  • 43 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11119 34
bread mold
(Neurospora crassa)
Ascomycetes NCU07112 34
  • 51.35 (n)
  • 42.38 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes hmt2 34
  • 50 (n)
  • 41.95 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 50 (a)
OneToMany
Species where no ortholog for SQRDL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SQRDL Gene

ENSEMBL:
Gene Tree for SQRDL (if available)
TreeFam:
Gene Tree for SQRDL (if available)

Paralogs for SQRDL Gene

Paralogs for SQRDL Gene

genes like me logo Genes that share paralogs with SQRDL: view

Variants for SQRDL Gene

Sequence variations from dbSNP and Humsavar for SQRDL Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
VAR_014959 -
rs2670806 -- 45,652,396(+) GGGGT(A/G)TGATC intron-variant
rs2670807 -- 45,652,516(+) ttttt(C/T)tagtt intron-variant
rs2670808 -- 45,652,561(+) ctgtt(C/T)tgaaa intron-variant
rs2670809 -- 45,652,575(+) ctgat(C/T)ttaag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SQRDL Gene

Variant ID Type Subtype PubMed ID
dgv1204n106 CNV deletion 24896259
esv23356 CNV gain 19812545
esv274920 OTHER complex 21479260
esv3361444 CNV duplication 20981092
esv3569553 CNV gain 25503493
esv3892684 CNV gain 25118596
nsv1160292 CNV duplication 26073780
nsv526945 CNV gain 19592680
nsv952619 CNV duplication 24416366

Variation tolerance for SQRDL Gene

Residual Variation Intolerance Score: 37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.52; 29.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SQRDL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SQRDL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SQRDL Gene

Disorders for SQRDL Gene

MalaCards: The human disease database

(1) MalaCards diseases for SQRDL Gene - From: GeneCards

Disorder Aliases PubMed IDs
ethylmalonic encephalopathy
  • encephalopathy, ethylmalonic
- elite association - COSMIC cancer census association via MalaCards
Search SQRDL in MalaCards View complete list of genes associated with diseases

Relevant External Links for SQRDL

Genetic Association Database (GAD)
SQRDL
Human Genome Epidemiology (HuGE) Navigator
SQRDL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SQRDL
genes like me logo Genes that share disorders with SQRDL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SQRDL Gene

Publications for SQRDL Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 65
  2. A fission yeast gene for mitochondrial sulfide oxidation. (PMID: 10224084) Vande Weghe J.G. … Ow D.W. (J. Biol. Chem. 1999) 2 3 4 65
  3. Human sulfide:quinone oxidoreductase catalyzes the first step in hydrogen sulfide metabolism and produces a sulfane sulfur metabolite. (PMID: 22852582) Jackson M.R. … Jorns M.S. (Biochemistry 2012) 3 4 65
  4. Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women. (PMID: 20966902) Croteau-Chonka D.C. … Mohlke K.L. (Obesity (Silver Spring) 2011) 3 46 65
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 65

Products for SQRDL Gene

Sources for SQRDL Gene

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