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Aliases for SQRDL Gene

Aliases for SQRDL Gene

  • Sulfide Quinone Reductase-Like (Yeast) 2 3 5
  • SQOR 3 4
  • Sulfide Dehydrogenase Like 3
  • EC 1.8.5.- 4
  • PRO1975 3
  • CGI-44 3

External Ids for SQRDL Gene

Previous GeneCards Identifiers for SQRDL Gene

  • GC15P041484
  • GC15P038973
  • GC15P043459
  • GC15P043643
  • GC15P043617
  • GC15P043714
  • GC15P045927
  • GC15P022749

Summaries for SQRDL Gene

Entrez Gene Summary for SQRDL Gene

  • The protein encoded by this gene may function in mitochondria to catalyze the conversion of sulfide to persulfides, thereby decreasing toxic concencrations of sulfide. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2012]

GeneCards Summary for SQRDL Gene

SQRDL (Sulfide Quinone Reductase-Like (Yeast)) is a Protein Coding gene. Diseases associated with SQRDL include ethylmalonic encephalopathy. Among its related pathways are Metabolism and Viral mRNA Translation. GO annotations related to this gene include oxidoreductase activity and sulfide:quinone oxidoreductase activity. An important paralog of this gene is ENSG00000260170.

UniProtKB/Swiss-Prot for SQRDL Gene

  • Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SQRDL Gene

Genomics for SQRDL Gene

Regulatory Elements for SQRDL Gene

Promoters for SQRDL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SQRDL on UCSC Golden Path with GeneCards custom track

Genomic Location for SQRDL Gene

Chromosome:
15
Start:
45,631,148 bp from pter
End:
45,691,294 bp from pter
Size:
60,147 bases
Orientation:
Plus strand

Genomic View for SQRDL Gene

Genes around SQRDL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SQRDL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SQRDL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SQRDL Gene

Proteins for SQRDL Gene

  • Protein details for SQRDL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6N5-SQRD_HUMAN
    Recommended name:
    Sulfide:quinone oxidoreductase, mitochondrial
    Protein Accession:
    Q9Y6N5
    Secondary Accessions:
    • Q9UQM8

    Protein attributes for SQRDL Gene

    Size:
    450 amino acids
    Molecular mass:
    49961 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available

neXtProt entry for SQRDL Gene

Proteomics data for SQRDL Gene at MOPED

Post-translational modifications for SQRDL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SQRDL Gene

Domains & Families for SQRDL Gene

Protein Domains for SQRDL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SQRDL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6N5

UniProtKB/Swiss-Prot:

SQRD_HUMAN :
  • Belongs to the SQRD family.
Family:
  • Belongs to the SQRD family.
genes like me logo Genes that share domains with SQRDL: view

No data available for Gene Families for SQRDL Gene

Function for SQRDL Gene

Molecular function for SQRDL Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro).

Enzyme Numbers (IUBMB) for SQRDL Gene

Gene Ontology (GO) - Molecular Function for SQRDL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070224 sulfide:quinone oxidoreductase activity IDA 22852582
genes like me logo Genes that share ontologies with SQRDL: view
genes like me logo Genes that share phenotypes with SQRDL: view

Animal Model Products

miRNA for SQRDL Gene

miRTarBase miRNAs that target SQRDL

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SQRDL Gene

Localization for SQRDL Gene

Subcellular locations from UniProtKB/Swiss-Prot for SQRDL Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SQRDL Gene COMPARTMENTS Subcellular localization image for SQRDL gene
Compartment Confidence
mitochondrion 5
cytosol 2
endoplasmic reticulum 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for SQRDL Gene

Pathways & Interactions for SQRDL Gene

genes like me logo Genes that share pathways with SQRDL: view

Gene Ontology (GO) - Biological Process for SQRDL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000098 sulfur amino acid catabolic process TAS --
GO:0070221 sulfide oxidation, using sulfide:quinone oxidoreductase TAS --
GO:0070813 hydrogen sulfide metabolic process IDA 22852582
genes like me logo Genes that share ontologies with SQRDL: view

No data available for SIGNOR curated interactions for SQRDL Gene

Drugs & Compounds for SQRDL Gene

(1) Drugs for SQRDL Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
genes like me logo Genes that share compounds with SQRDL: view

Transcripts for SQRDL Gene

Unigene Clusters for SQRDL Gene

Sulfide quinone reductase-like (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SQRDL Gene

No ASD Table

Relevant External Links for SQRDL Gene

GeneLoc Exon Structure for
SQRDL
ECgene alternative splicing isoforms for
SQRDL

Expression for SQRDL Gene

mRNA expression in normal human tissues for SQRDL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SQRDL Gene

This gene is overexpressed in Whole Blood (x7.1) and Colon - Transverse (x5.3).

Protein differential expression in normal tissues from HIPED for SQRDL Gene

This gene is overexpressed in Nasal epithelium (31.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SQRDL Gene



SOURCE GeneReport for Unigene cluster for SQRDL Gene Hs.511251

genes like me logo Genes that share expression patterns with SQRDL: view

Protein tissue co-expression partners for SQRDL Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SQRDL Gene

Orthologs for SQRDL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SQRDL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SQRDL 35
  • 88.15 (n)
  • 91.33 (a)
SQRDL 36
  • 87 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SQRDL 35
  • 89.04 (n)
  • 91.78 (a)
SQRDL 36
  • 92 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Sqrdl 35
  • 83.11 (n)
  • 86.89 (a)
Sqrdl 16
Sqrdl 36
  • 87 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia SQRDL 35
  • 98.89 (n)
  • 98.67 (a)
SQRDL 36
  • 99 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Sqrdl 35
  • 84.52 (n)
  • 89.78 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 80 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 75 (a)
OneToMany
chicken
(Gallus gallus)
Aves SQRDL 35
  • 73.96 (n)
  • 79.95 (a)
-- 36
  • 78 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 78 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia sqrdl 35
  • 70.66 (n)
  • 74.43 (a)
Str.1787 35
African clawed frog
(Xenopus laevis)
Amphibia sqrdl-prov 35
zebrafish
(Danio rerio)
Actinopterygii sqrdl 35
  • 69.45 (n)
  • 75.42 (a)
wufj81h04 35
sqrdl 36
  • 66 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4140 35
fruit fly
(Drosophila melanogaster)
Insecta CG14997 37
  • 51 (a)
CG14997 35
  • 56.97 (n)
  • 51.68 (a)
CG14997 36
  • 47 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003142 35
  • 57.25 (n)
  • 53.32 (a)
worm
(Caenorhabditis elegans)
Secernentea F02H6.5 37
  • 40 (a)
Y9C9A.16 37
  • 43 (a)
sqrd-1 35
  • 52.23 (n)
  • 46.04 (a)
sqrd-1 36
  • 39 (a)
ManyToMany
Y9C9A.16 36
  • 43 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11119 35
bread mold
(Neurospora crassa)
Ascomycetes NCU07112 35
  • 51.35 (n)
  • 42.38 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes hmt2 35
  • 50 (n)
  • 41.95 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToMany
Species with no ortholog for SQRDL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SQRDL Gene

ENSEMBL:
Gene Tree for SQRDL (if available)
TreeFam:
Gene Tree for SQRDL (if available)

Paralogs for SQRDL Gene

Paralogs for SQRDL Gene

genes like me logo Genes that share paralogs with SQRDL: view

Variants for SQRDL Gene

Sequence variations from dbSNP and Humsavar for SQRDL Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
VAR_014959 -
rs10643 -- 45,689,119(+) GAGCC(A/G)CTAGA reference, synonymous-codon
rs11633 -- 45,691,256(-) GAAAG(A/G)TAAAA utr-variant-3-prime
rs648734 -- 45,656,917(+) CTCAT(A/G)GCTCA intron-variant
rs648773 -- 45,656,944(+) GGATT(A/G)CAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SQRDL Gene

Variant ID Type Subtype PubMed ID
nsv904188 CNV Gain 21882294
dgv2379n71 CNV Gain 21882294
nsv904190 CNV Gain 21882294
nsv526945 CNV Gain 19592680
esv274920 CNV Complex 21479260
esv23356 CNV Gain 19812545

Variation tolerance for SQRDL Gene

Residual Variation Intolerance Score: 37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.52; 29.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SQRDL Gene

HapMap Linkage Disequilibrium report
SQRDL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SQRDL Gene

Disorders for SQRDL Gene

MalaCards: The human disease database

(1) MalaCards diseases for SQRDL Gene - From: GeneCards

Disorder Aliases PubMed IDs
ethylmalonic encephalopathy
  • early myoclonic encephalopathy
- elite association - COSMIC cancer census association via MalaCards
Search SQRDL in MalaCards View complete list of genes associated with diseases

Relevant External Links for SQRDL

Genetic Association Database (GAD)
SQRDL
Human Genome Epidemiology (HuGE) Navigator
SQRDL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SQRDL
genes like me logo Genes that share disorders with SQRDL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SQRDL Gene

Publications for SQRDL Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 67
  2. A fission yeast gene for mitochondrial sulfide oxidation. (PMID: 10224084) Vande Weghe J.G. … Ow D.W. (J. Biol. Chem. 1999) 2 3
  3. Ski regulates Hippo and TAZ signaling to suppress breast cancer progression. (PMID: 25670202) Rashidian J. … Luo K. (Sci Signal 2015) 3
  4. Organization of the human mitochondrial hydrogen sulfide oxidation pathway. (PMID: 25225291) Libiad M. … Banerjee R. (J. Biol. Chem. 2014) 3
  5. Novel genetic variants modify the effect of smoking on carotid plaque burden in Hispanics. (PMID: 24954085) Della-Morte D. … Dong C. (J. Neurol. Sci. 2014) 3

Products for SQRDL Gene

Sources for SQRDL Gene

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