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Aliases for SQOR Gene

Aliases for SQOR Gene

  • Sulfide Quinone Oxidoreductase 2 3 4 5
  • SQRDL 3 4
  • Sulfide:Quinone Oxidoreductase, Mitochondrial 3
  • Sulfide Quinone Reductase-Like (Yeast) 2
  • Sulfide Quinone Reductase-Like 3
  • Sulfide Dehydrogenase Like 3
  • EC 1.8.5.- 4
  • PRO1975 3
  • CGI-44 3
  • SQR 3

External Ids for SQOR Gene

Previous HGNC Symbols for SQOR Gene

  • SQRDL

Summaries for SQOR Gene

Entrez Gene Summary for SQOR Gene

  • The protein encoded by this gene may function in mitochondria to catalyze the conversion of sulfide to persulfides, thereby decreasing toxic concencrations of sulfide. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2012]

GeneCards Summary for SQOR Gene

SQOR (Sulfide Quinone Oxidoreductase) is a Protein Coding gene. Among its related pathways are Metabolism and Sulfur amino acid metabolism. An important paralog of this gene is ENSG00000260170.

UniProtKB/Swiss-Prot for SQOR Gene

  • Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro).

Additional gene information for SQOR Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SQOR Gene

Genomics for SQOR Gene

Regulatory Elements for SQOR Gene

Enhancers for SQOR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H045636 1.7 FANTOM5 ENCODE dbSUPER 24.4 +8.8 8776 6.7 PKNOX1 FOXA2 ARID4B FEZF1 DMAP1 YY1 ZNF766 FOS REST MIER2 C15orf48 SQOR BLOC1S6 ENSG00000259539 LOC100533853 SPATA5L1 SHF GC15P045696
GH15H045585 1.4 ENCODE dbSUPER 16.2 -43.4 -43374 4.3 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SQOR SPG11 SLC30A4 ENSG00000259539 GC15P045592 ENSG00000260170
GH15H045454 1.7 FANTOM5 ENCODE dbSUPER 10.6 -174.7 -174660 4.4 ATF1 ARNT SIN3A FEZF1 GLI4 BRCA1 ZNF143 ZNF207 ATF7 FOS C15orf48 LOC100533853 SPATA5L1 MIR147B SLC30A4 SQOR BLOC1S6 GC15P045452 GC15M045480
GH15H044853 1.4 Ensembl ENCODE dbSUPER 10.8 -777.5 -777507 0.7 YBX3 ELF3 FOXA2 RB1 ARID4B ZNF2 RAD21 RARA CHAMP1 ZNF143 SORD SQOR LOC105370798 ENSG00000238845
GH15H044733 1.4 Ensembl ENCODE dbSUPER 10.8 -895.3 -895288 4.1 HDAC1 YBX3 HDGF ATF1 TBL1XR1 ARNT NFRKB YBX1 ZBTB40 BATF TRIM69 SQOR GC15P044732 ENSG00000276121
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SQOR on UCSC Golden Path with GeneCards custom track

Genomic Locations for SQOR Gene

Genomic Locations for SQOR Gene
chr15:45,631,148-45,691,294
(GRCh38/hg38)
Size:
60,147 bases
Orientation:
Plus strand
chr15:45,923,346-45,983,492
(GRCh37/hg19)

Genomic View for SQOR Gene

Genes around SQOR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SQOR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SQOR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SQOR Gene

Proteins for SQOR Gene

  • Protein details for SQOR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6N5-SQOR_HUMAN
    Recommended name:
    Sulfide:quinone oxidoreductase, mitochondrial
    Protein Accession:
    Q9Y6N5
    Secondary Accessions:
    • Q9UQM8

    Protein attributes for SQOR Gene

    Size:
    450 amino acids
    Molecular mass:
    49961 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available

neXtProt entry for SQOR Gene

Post-translational modifications for SQOR Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SQOR Gene

Domains & Families for SQOR Gene

Gene Families for SQOR Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SQOR Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SQOR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6N5

UniProtKB/Swiss-Prot:

SQOR_HUMAN :
  • Belongs to the SQRD family.
Family:
  • Belongs to the SQRD family.
genes like me logo Genes that share domains with SQOR: view

Function for SQOR Gene

Molecular function for SQOR Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro).

Enzyme Numbers (IUBMB) for SQOR Gene

Phenotypes From GWAS Catalog for SQOR Gene

Gene Ontology (GO) - Molecular Function for SQOR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
GO:0048038 quinone binding IEA --
GO:0070224 sulfide:quinone oxidoreductase activity IDA 22852582
genes like me logo Genes that share ontologies with SQOR: view
genes like me logo Genes that share phenotypes with SQOR: view

miRNA for SQOR Gene

miRTarBase miRNAs that target SQOR

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SQOR Gene

Localization for SQOR Gene

Subcellular locations from UniProtKB/Swiss-Prot for SQOR Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SQOR gene
Compartment Confidence
mitochondrion 5
cytosol 2
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SQOR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane TAS --
genes like me logo Genes that share ontologies with SQOR: view

Pathways & Interactions for SQOR Gene

genes like me logo Genes that share pathways with SQOR: view

Gene Ontology (GO) - Biological Process for SQOR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
GO:0070221 sulfide oxidation, using sulfide:quinone oxidoreductase TAS,IDA --
GO:0070813 hydrogen sulfide metabolic process IDA 22852582
genes like me logo Genes that share ontologies with SQOR: view

No data available for SIGNOR curated interactions for SQOR Gene

Drugs & Compounds for SQOR Gene

(1) Drugs for SQOR Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
genes like me logo Genes that share compounds with SQOR: view

Transcripts for SQOR Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SQOR Gene

No ASD Table

Relevant External Links for SQOR Gene

GeneLoc Exon Structure for
SQOR
ECgene alternative splicing isoforms for
SQOR

Expression for SQOR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of SQOR Gene:

SQOR

Evidence on tissue expression from TISSUES for SQOR Gene

  • Lung(4.6)
  • Liver(4.5)
  • Nervous system(4.3)
  • Intestine(3.5)
  • Pancreas(2.2)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with SQOR: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SQOR Gene

Orthologs for SQOR Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SQOR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SQRDL 33 34
  • 98.89 (n)
dog
(Canis familiaris)
Mammalia SQRDL 33 34
  • 89.04 (n)
cow
(Bos Taurus)
Mammalia SQRDL 33 34
  • 88.15 (n)
rat
(Rattus norvegicus)
Mammalia Sqrdl 33
  • 84.52 (n)
mouse
(Mus musculus)
Mammalia Sqrdl 33 34
  • 83.11 (n)
Sqor 16
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 80 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 75 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 78 (a)
OneToMany
SQRDL 33
  • 73.96 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 78 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia sqrdl 33
  • 70.66 (n)
Str.1787 33
African clawed frog
(Xenopus laevis)
Amphibia sqrdl-prov 33
zebrafish
(Danio rerio)
Actinopterygii sqrdl 33 34
  • 69.45 (n)
wufj81h04 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4140 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003142 33
  • 57.25 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14997 33 34
  • 56.97 (n)
worm
(Caenorhabditis elegans)
Secernentea sqrd-1 33 34
  • 52.23 (n)
Y9C9A.16 34
  • 43 (a)
ManyToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU07112 33
  • 51.35 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes hmt2 33
  • 50 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 50 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11119 33
Species where no ortholog for SQOR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SQOR Gene

ENSEMBL:
Gene Tree for SQOR (if available)
TreeFam:
Gene Tree for SQOR (if available)

Paralogs for SQOR Gene

Paralogs for SQOR Gene

genes like me logo Genes that share paralogs with SQOR: view

Variants for SQOR Gene

Sequence variations from dbSNP and Humsavar for SQOR Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000012732 -- 45,650,323(+) GGGAG(G/T)GTTAC intron-variant
rs1000078805 -- 45,649,308(+) TTAGA(C/G)TGCAG intron-variant
rs1000081506 -- 45,673,039(+) TGAGC(A/G)CCACA intron-variant
rs1000149160 -- 45,669,510(+) GGAAG(A/C)CCTTC intron-variant
rs1000168194 -- 45,683,785(+) AACCA(A/G)TTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SQOR Gene

Variant ID Type Subtype PubMed ID
nsv952619 CNV duplication 24416366
nsv526945 CNV gain 19592680
nsv1160292 CNV duplication 26073780
esv3892684 CNV gain 25118596
esv3569553 CNV gain 25503493
esv3361444 CNV duplication 20981092
esv274920 OTHER complex 21479260
esv23356 CNV gain 19812545
dgv1204n106 CNV deletion 24896259

Variation tolerance for SQOR Gene

Residual Variation Intolerance Score: 37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.52; 29.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SQOR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SQOR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SQOR Gene

Disorders for SQOR Gene

Relevant External Links for SQOR

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SQOR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SQOR

No disorders were found for SQOR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SQOR Gene

Publications for SQOR Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4 60
  2. A fission yeast gene for mitochondrial sulfide oxidation. (PMID: 10224084) Vande Weghe JG … Ow DW (The Journal of biological chemistry 1999) 2 3 4 60
  3. Human sulfide:quinone oxidoreductase catalyzes the first step in hydrogen sulfide metabolism and produces a sulfane sulfur metabolite. (PMID: 22852582) Jackson MR … Jorns MS (Biochemistry 2012) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for SQOR Gene

Sources for SQOR Gene

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