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SQLE Gene

protein-coding   GIFtS: 63
GCID: GC08P126010

Squalene Epoxidase

  See SQLE-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Squalene Epoxidase1 2 3
SE2 3
Squalene Monooxygenase2
EC 1.14.13.1323
ERG13

External Ids:    HGNC: 112791   Entrez Gene: 67132   Ensembl: ENSG000001045497   OMIM: 6020195   UniProtKB: Q145343   

Export aliases for SQLE gene to outside databases

Previous GC identifers: GC08P125035 GC08P126015 GC08P125679 GC08P125968 GC08P126079 GC08P121334


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SQLE Gene:
Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the
rate-limiting enzymes in this pathway. (provided by RefSeq, Jul 2008)

GeneCards Summary for SQLE Gene:
SQLE (squalene epoxidase) is a protein-coding gene. Diseases associated with SQLE include tinea cruris, and tinea pedis. GO annotations related to this gene include squalene monooxygenase activity and flavin adenine dinucleotide binding.

UniProtKB/Swiss-Prot: ERG1_HUMAN, Q14534
Function: Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the
rate-limiting enzymes in this pathway

Gene Wiki entry for SQLE (Squalene monooxygenase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_008046.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the SQLE gene promoter:
         HOXA9   HOXA9B   AML1a   NRSF form 2   Arnt   RORalpha2   Meis-1a   NF-Y   CBF(2)   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SQLE promoter sequence
   Search Chromatin IP Primers for SQLE

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SQLE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.1   Ensembl cytogenetic band:  8q24.13   HGNC cytogenetic band: 8q24.1

SQLE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SQLE gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P126010:  view genomic region     (about GC identifiers)

Start:
126,010,720 bp from pter      End:
126,034,525 bp from pter
Size:
23,806 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ERG1_HUMAN, Q14534 (See protein sequence)
Recommended Name: Squalene monooxygenase  
Size: 574 amino acids; 63923 Da
Cofactor: FAD
Subunit: May form a complex with squalene synthase
Secondary accessions: Q9UEK6

Explore the universe of human proteins at neXtProt for SQLE: NX_Q14534

Explore proteomics data for SQLE at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys90, Lys290, Lys426, Lys436
  • Modification sites at PhosphoSitePlus

  • See SQLE Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003120.2  
    ENSEMBL proteins: 
     ENSP00000430331   ENSP00000265896   ENSP00000428239   ENSP00000429916  
    Reactome Protein details: Q14534

    SQLE Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for SQLE
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SQLE
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    Novus Biologicals SQLE Proteins
    Novus Biologicals SQLE Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SQLE

     
    Search eBioscience for Proteins for SQLE 

     
    antibodies-online proteins for SQLE (4 products) 

     
    antibodies-online peptides for SQLE

    SQLE Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    antibodies-online antibodies for SQLE (21 products) 

    SQLE Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SQLE
    Cloud-Clone Corp. CLIAs for SQLE
    Search eBioscience for ELISAs for SQLE 
    antibodies-online kits for SQLE (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR013698 Squalene_epoxidase
     IPR003042 Rng_hydrolase-like
     IPR001327 Pyr_OxRdtase_NAD-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q14534

    ProtoNet protein and cluster: Q14534

    1 Blocks protein domain: IPB013698 Squalene epoxidase

    UniProtKB/Swiss-Prot: ERG1_HUMAN, Q14534
    Similarity: Belongs to the squalene monooxygenase family


    Find genes that share domains with SQLE           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ERG1_HUMAN, Q14534
    Function: Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the
    rate-limiting enzymes in this pathway
    Catalytic activity: Squalene + NADPH + O(2) = (3S)-2,3-epoxy-2,3-dihydrosqualene + NADP(+) + H(2)O

         Genatlas biochemistry entry for SQLE:
    squalene epoxidase catalyzing the first oxygenation step in sterol biosynthesis

         Enzyme Number (IUBMB): EC 1.14.13.1321

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004506squalene monooxygenase activity TAS--
    GO:0016491oxidoreductase activity ----
    GO:0050660flavin adenine dinucleotide binding IEA--
         
    Find genes that share ontologies with SQLE           About GenesLikeMe


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Sqle):
     behavior/neurological  craniofacial  growth/size/body  immune system  integument 
     mortality/aging  respiratory system  skeleton 

    Find genes that share phenotypes with SQLE           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SQLE

    miRNA
    Products:
        
    miRTarBase miRNAs that target SQLE:
    hsa-let-7e-5p (MIRT051529), hsa-mir-335-5p (MIRT018458)

    Block miRNA regulation of human, mouse, rat SQLE using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate SQLE:
    hsa-miR-579 hsa-miR-518a-5p hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidSQLE 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SQLE
    Predesigned siRNA for gene silencing in human, mouse, rat SQLE

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SQLE

    Clone
    Products:
         
    OriGene clones in human, mouse for SQLE (see all 7)
    OriGene ORF clones in mouse, rat for SQLE
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SQLE (NM_003129)
    Sino Biological Human cDNA Clone for SQLE
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SQLE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SQLE

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for SQLE
    Browse ESI BIO Cell Lines and PureStem Progenitors for SQLE 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SQLE


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ERG1_HUMAN, Q14534: Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass
    membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane3
    cytosol1
    extracellular1
    golgi apparatus1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral component of membrane IEA--
    GO:0043231intracellular membrane-bounded organelle ----

    Find genes that share ontologies with SQLE           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SQLE About    
    See pathways by source

    SuperPathContained pathways About
    1superpathway of cholesterol biosynthesis
    superpathway of cholesterol biosynthesis0.85
    Steroid biosynthesis0.57
    Cholesterol biosynthesis0.85
    cholesterol biosynthesis III (via desmosterol)0.00
    Cholesterol biosynthesis0.62
    epoxysqualene biosynthesis0.00
    cholesterol biosynthesis II (via 24,25-dihydrolanosterol)0.59
    cholesterol biosynthesis I0.00
    2Regulation of Cholesterol Biosynthesis by SREBP (SREBF)
    Regulation of Cholesterol Biosynthesis by SREBP (SREBF)0.75
    SREBP signalling0.31
    Activation of Gene Expression by SREBP (SREBF)0.75
    3Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    4Statin Pathway
    Statin Pathway, Pharmacodynamics0.73
    Statin Pathway0.73
    5Bisphosphonate Pathway, Pharmacodynamics
    Bisphosphonate Pathway, Pharmacodynamics


    Find genes that share SuperPaths with SQLE           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected BioSystems Pathways for SQLE (see all 8)
        Cholesterol biosynthesis
    Statin Pathway
    SREBP signalling
    cholesterol biosynthesis I
    epoxysqualene biosynthesis


    2 Reactome Pathways for SQLE
        Cholesterol biosynthesis
    Activation of gene expression by SREBF (SREBP)

    2 PharmGKB Pathways for SQLE
        Bisphosphonate Pathway, Pharmacodynamics
    Statin Pathway, Pharmacodynamics

    2 Kegg Pathways  (Kegg details for SQLE):
        Steroid biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: ERG1_HUMAN, Q14534
    Pathway: Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 2/3

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SQLE
    Interactions:

        GeneGlobe Interaction Network for SQLE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SQLE (Q145343 ENSP000002658964) via UniProtKB, MINT, STRING, and/or I2D (see all 163)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    MSMO1Q158003, ENSP000002615074I2D: score=2 STRING: ENSP00000261507
    COQ3Q9NZJ63, ENSP000002547594I2D: score=1 STRING: ENSP00000254759
    DNM1LO004293, ENSP000002664814I2D: score=1 STRING: ENSP00000266481
    SC5DO758453, ENSP000002640274I2D: score=1 STRING: ENSP00000264027
    UBA52P629873, ENSP000003881074I2D: score=1 STRING: ENSP00000388107
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006695cholesterol biosynthetic process TAS--
    GO:0006725cellular aromatic compound metabolic process IEA--
    GO:0008203cholesterol metabolic process ----
    GO:0010033response to organic substance IEA--
    GO:0016126sterol biosynthetic process NAS9286711

    Find genes that share ontologies with SQLE           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for SQLE
      Browse compounds at ApexBio 

    Browse Tocris compounds for SQLE (ERG1)

    4 HMDB Compounds for SQLE    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    Ferricytochrome553-12-8 (FREE ACID) (see all 21)1818-68-4--
    Ferrocytochrome553-12-8 (FREE ACID) (see all 21)1818-68-4--
    Squalene(E,E,E,E)-Squalene (see all 10)111-02-4--

    4 DrugBank Compounds for SQLE    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    TerbinafineTerbinafine HCl (see all 3)91161-71-6targetinhibitor1543672 14638499 11752352 19874252 12226513 12100530 12477372 12963042
    ButenafineButenafina [INN-Spanish] (see all 5)101828-21-1targetinhibitor18624686 12499173 11752352 8494375 16079485 17642865
    Naftifine-- 65472-88-0targetinhibitor3877503 12499173 11752352 8834895 1287164 1951574
    Ellagic Acid-- 476-66-4targetinhibitor11520216

    Selected Novoseek inferred chemical compound relationships for SQLE gene (see all 25)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    squalene 97.1 160 1964954 (7), 11181753 (6), 9324936 (5), 9300786 (4) (see all 75)
    naftifine 91.2 3 17896810 (1), 1951574 (1), 12499173 (1)
    dimethyltelluride 89 1 11181753 (1)
    terbinafine 87.5 31 15980358 (5), 15682641 (2), 16466954 (2), 15215099 (2) (see all 16)
    ergosterol 84.8 17 18096502 (2), 12477372 (2), 16466954 (2), 1287164 (1) (see all 10)
    lanosterol 81.1 5 16079485 (1), 7791529 (1), 15893902 (1)
    butenafine 78.4 2 16079485 (1), 12499173 (1)
    tolnaftate 78.4 1 12499173 (1)
    sterol 74.5 11 8626488 (1), 7791529 (1), 19680554 (1), 1803242 (1) (see all 9)
    tellurium 67.4 9 11181753 (5), 8090356 (1)



    Find genes that share compounds with SQLE           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SQLE gene: 
    NM_003129.3  

    Unigene Cluster for SQLE:

    Squalene epoxidase
    Hs.71465  [show with all ESTs]
    Unigene Representative Sequence: NM_003129
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000523430 ENST00000265896(uc011liq.2) ENST00000521232 ENST00000518931
    ENST00000520493 ENST00000518604
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate SQLE:
    hsa-miR-579 hsa-miR-518a-5p hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidSQLE 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: SQLE (NM_003129)
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    Primer
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    OriGene qPCR primer pairs and template standards for SQLE
    OriGene qSTAR qPCR primer pairs in human, mouse for SQLE
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SQLE
      QuantiTect SYBR Green Assays in human, mouse, rat SQLE
      QuantiFast Probe-based Assays in human, mouse, rat SQLE

    Additional mRNA sequence: 

    AF098865.1 AK225085.1 AK295302.1 AK301792.1 AK313384.1 BC017033.1 BX647400.1 BX647605.1 
    D78129.1 D78130.1 

    10 DOTS entries:

    DT.97857247  DT.117824  DT.40299615  DT.95210936  DT.100757709  DT.92441125  DT.95210960  DT.75155650 
    DT.92441126  DT.95210930 

    Selected AceView cDNA sequences (see all 265):

    BI439805 AA558927 AI216185 BP872774 W80742 AU125689 BP368846 AA132213 
    F05344 AI471982 AI802289 AW170130 AI341546 AL046067 AI084342 AU102597 
    BM683292 CK300375 AU102598 AU136459 BM069543 AA580614 AI143944 BI324843 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SQLE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAATAAAAT
    SQLE Expression
    About this image


    SQLE expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Thalamus
     
     Ovary (Reproductive System)
             Mature follicles
     
     Testis (Reproductive System)
    SQLE Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SQLE Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.71465
        Custom PCR Arrays for SQLE
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SQLE
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    QuantiFast Probe-based Assays in human, mouse, rat SQLE
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SQLE

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SQLE gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sqle1 , 5 squalene epoxidase1, 5 82.98(n)1
    84.44(a)1
      15 (25.16 cM)5
    207751  NM_009270.31  NP_033296.11 
     593150775 
    chicken
    (Gallus gallus)
    Aves SQLE1 squalene epoxidase 73.71(n)
    71.73(a)
      420335  NM_001194927.1  NP_001181856.1 
    lizard
    (Anolis carolinensis)
    Reptilia SQLE6
    squalene epoxidase
    68(a)
    1 ↔ 1
    4(5772450-5808567)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia sqle1 squalene epoxidase 67.21(n)
    68.35(a)
      100491400  XM_002939513.2  XP_002939559.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sqlea1 squalene epoxidase a 65.17(n)
    65.77(a)
      799528  NM_001110039.1  NP_001103509.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ERG1(YGR175C)4
    ERG11
    Squalene epoxidase, catalyzes the epoxidation of squalene more4
    ERG11
    49.62(n)1
    40(a)1
      7(848423-846933)4
    8530861, 4  NP_011691.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons XF11 XF1 50.72(n)
    45.13(a)
      842213  NM_104624.3  NP_564734.1 
    rice
    (Oryza sativa)
    Liliopsida Os.209692 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 75.66(n)    AK065032.1 


    ENSEMBL Gene Tree for SQLE (if available)
    TreeFam Gene Tree for SQLE (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SQLE gene
    2 SIMAP similar genes for SQLE using alignment to 4 protein entries:     ERG1_HUMAN (see all proteins):
    ERG1    DKFZp686B0215

    Find genes that share paralogs with SQLE           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SQLE
    PGOHUM00000257216


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SQLE (see all 556)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1906282651,2
    C--126008790(+) CAGAGC/TGAGAC 1 -- us2k10--------
    rs78152711,2
    C,F--126008885(+) CAGTTT/CATTGA 1 -- us2k12Minor allele frequency- C:0.24WA 120
    rs1480285101,2
    C--126008966(+) ATGTCA/CGTTCA 1 -- us2k10--------
    rs37635451,2
    C--126009021(+) AGAATA/GAAAGT 1 -- us2k14Minor allele frequency- G:0.08WA NA EA 360
    rs1824927211,2
    --126009106(+) TTTGGC/TTTCAT 1 -- us2k10--------
    rs1417537361,2
    C--126009368(+) AGTTGC/GCTTCT 1 -- us2k10--------
    rs786837021,2
    F--126009595(+) ATCTAG/AAGATT 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs758964191,2
    F--126009675(+) AGCCAC/AGCTCC 1 -- us2k11Minor allele frequency- A:0.07WA 118
    rs38532551,2
    C,F,A,H--126009831(-) AGTCTC/TGGAGT 1 -- us2k113Minor allele frequency- T:0.10NS EA NA WA 1488
    rs1505872941,2
    --126009853(+) TTGCTA/CCCTCG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SQLE (126010720 - 126034525 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SQLE:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv268241CNV Insertion20981092
    esv274006CNV Insertion20981092
    nsv891434CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SQLE
    DNA2.0 Custom Variant and Variant Library Synthesis for SQLE

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602019    OMIM disorders: --

    5 diseases for SQLE:    
    About MalaCards
    tinea cruris    tinea pedis    pityriasis versicolor    tinea capitis
    candida glabrata

    3 diseases from the University of Copenhagen DISEASES database for SQLE:
    Tinea cruris     Tinea pedis     Tinea capitis

    Find genes that share disorders with SQLE           About GenesLikeMe

    3 Novoseek inferred disease relationships for SQLE gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    infection fungal 36 2 17531123 (1), 12956204 (1)
    demyelination 30 1 11181753 (1)
    hypercholesterolemia 28 1 1649182 (1)

    Genetic Association Database (GAD): SQLE
    Human Genome Epidemiology (HuGE) Navigator: SQLE (5 documents)

    Export disorders for SQLE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SQLE gene, integrated from 10 sources (see all 109):
    (articles sorted by number of sources associating them with SQLE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Localization of the squalene epoxidase gene (SQLE) to human chromosome region 8q24.1. (PubMed id 9286711)1, 2, 3, 9 Nagai M.... Ono T. (Genomics 1997)
    2. Transcriptional regulation of squalene epoxidase by sterols and inhibitors in HeLa cells. (PubMed id 8626488)1, 2, 9 Nakamura Y.... Ono T. (J. Biol. Chem. 1996)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (J. Lipid Res. 2008)
    5. Squalene epoxidase, located on chromosome 8q24.1, is upregulated in 8q+ breast cancer and indicates poor clinical outcome in stage I and II disease. (PubMed id 18728668)1, 9 Helms M.W....Brandt B.H. (Br. J. Cancer 2008)
    6. Cloning, heterologous expression, and enzymological characterization of human squalene monooxygenase. (PubMed id 10666321)1, 9 Laden B.P....Porter T.D. (Arch. Biochem. Biophys. 2000)
    7. Terbinafine: a review of its use in onychomycosis in adults. (PubMed id 12477372)7, 9 Darkes M.J....Goa K.L. (Am J Clin Dermatol 2003)
    8. Mode of action of anti-Candida drugs: focus on terconazole and other ergosterol biosynthesis inhibitors. (PubMed id 1951574)7, 9 Vanden Bossche H. and Marichal P. (Am. J. Obstet. Gynecol. 1991)
    9. In vitro antifungal activity of ZJ-522, a new triazole restructured from fluconazole and butenafine, against clinically important fungi in comparison with fluconazole and butenafine. (PubMed id 16079485)7, 9 Gao P.H....Jiang Y.Y. (amp 2005)
    10. Clinical Trichophyton rubrum strain exhibiting primary resistance to terbinafine. (PubMed id 12499173)7, 9 Mukherjee P.K....Ghannoum M.A. (Antimicrob. Agents Chemother. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6713 HGNC: 11279 AceView: SQLE Ensembl:ENSG00000104549 euGenes: HUgn6713
    ECgene: SQLE Kegg: 6713 H-InvDB: SQLE

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SQLE Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SQLE gene:
    Search GeneIP for patents involving SQLE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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