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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SQLE Gene

protein-coding GIFtS: 59
GCID: GC08P126010

squalene epoxidase

Explore 14 diseases affiliated with
SQLE via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Squalene Epoxidase¹ ² ³
SE² ³
Squalene Monooxygenase²
EC 1.14.13.132³
ERG1³

External Ids:	HGNC: 11279¹	Entrez Gene: 6713²	Ensembl: ENSG00000104549⁷	OMIM: 602019⁵	UniProtKB: Q14534³

Export aliases for SQLE gene to outside databases

Previous GC identifers: GC08P125035 GC08P126015 GC08P125679 GC08P125968 GC08P126079 GC08P121334

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SQLE:

Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the

rate-limiting enzymes in this pathway. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ERG1_HUMAN, Q14534

Function: Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting

enzymes in this pathway

Gene Wiki entry for SQLE (Squalene monooxygenase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_008046.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SQLE gene promoter:
HOXA9 HOXA9B AML1a NRSF form 2 Arnt RORalpha2 Meis-1a NF-Y CBF(2) Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SQLE promoter sequence

Search SABiosciences Chromatin IP Primers for SQLE

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SQLE

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.1 Ensembl cytogenetic band: 8q24.13 HGNC cytogenetic band: 8q24.1

SQLE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SQLE gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P126010: view genomic region (about GC identifiers)

Start:	126,010,720 bp from pter	End:	126,034,525 bp from pter
Size:	23,806 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ERG1_HUMAN, Q14534 (See protein sequence)

Recommended Name: Squalene monooxygenase

Size: 574 amino acids; 63923 Da

Cofactor: FAD

Subunit: May form a complex with squalene synthase

Subcellular location: Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass

membrane protein

Secondary accessions: Q9UEK6

Explore the universe of human proteins at neXtProt for SQLE: NX_Q14534

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q14534

SQLE Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003120.2

ENSEMBL proteins:

ENSP00000430331 ENSP00000265896 ENSP00000428239 ENSP00000429916

Reactome Protein details: Q14534
Human Recombinant Protein Products for SQLE:

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	Novus Biologicals SQLE Proteins Novus Biologicals SQLE Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SQLE

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0005792	microsome	--	--
GO:0016021	integral to membrane	IEA	--
GO:0043231	intracellular membrane-bounded organelle	NAS	--

SQLE for ontologies About GeneDecksing

SQLE Antibody Products:

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Assay Products for SQLE:

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	Uscn ELISAs and CLIAs for SQLE

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SQLE for domains About GeneDecksing

3 InterPro domains/families:

IPR013698 Squalene_epoxidase

IPR003042 Rng_hydrolase-like

IPR001327 Pyr_OxRdtase_NAD-bd_dom

Graphical View of Domain Structure for InterPro Entry Q14534

ProtoNet protein and cluster: Q14534

1 Blocks protein family: IPB013698 Squalene epoxidase

UniProtKB/Swiss-Prot: ERG1_HUMAN, Q14534

Similarity: Belongs to the squalene monooxygenase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ERG1_HUMAN, Q14534

Function: Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting

enzymes in this pathway

Catalytic activity: Squalene + NADPH + O(2) = (3S)-2,3-epoxy-2,3-dihydrosqualene + NADP(+) + H(2)O

Genatlas biochemistry entry for SQLE:

squalene epoxidase catalyzing the first oxygenation step in sterol biosynthesis

Enzyme Number (IUBMB): EC 1.14.13.132¹

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004506	squalene monooxygenase activity	TAS	--
GO:0050660	flavin adenine dinucleotide binding	IEA	--

SQLE for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SQLE

miRNA Products:		OriGene 3'-UTR Clone: SQLE Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SQLE
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate SQLE:
		hsa-miR-579 hsa-miR-518a-5p hsa-miR-664
		SwitchGear 3'UTR luciferase reporter plasmid: SQLE 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SQLE (see all 7) OriGene shRNA RFP: SQLE OriGene siRNA: SQLE
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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SQLE (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SQLE (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SQLE (NM_003129)
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SQLE

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

cholesterol biosynthesis III (via desmosterol)

	cholesterol biosynthesis III (via desmosterol)	1.00			cholesterol biosynthesis II (via 24,25-dihydrolanosterol)	1.00
	cholesterol biosynthesis I	1.00			Steroid biosynthesis	0.60

Regulation of Cholesterol Biosynthesis by SREBP (SREBF)

	Regulation of Cholesterol Biosynthesis by SREBP (SREBF)	1.00			SREBP signalling	0.46
	Activation of Gene Expression by SREBP (SREBF)	0.67

Metabolism

	Metabolism	1.00			Metabolism of lipids and lipoproteins	0.34
	Metabolic pathways	0.38

Cholesterol biosynthesis

	Cholesterol biosynthesis	1.00			Cholesterol Biosynthesis	0.68
	superpathway of cholesterol biosynthesis	0.81

Statin Pathway, Pharmacodynamics

Statin Pathway, Pharmacodynamics

1.00

Statin Pathway

0.80

Pathway sources
See GeneCards unified pathways
Show all pathways

5/8 BioSystems Pathways for SQLE (see all 8)

	Cholesterol Biosynthesis
	Statin Pathway
	SREBP signalling
	superpathway of cholesterol biosynthesis
	cholesterol biosynthesis I

5/6 Reactome Pathways for SQLE (see all 6)

	Expression of Squalene Monooxygenase (SQLE)
	Metabolism
	Cholesterol biosynthesis
	Activation of Gene Expression by SREBP (SREBF)
	Metabolism of lipids and lipoproteins

2 PharmGKB Pathways for SQLE

	Bisphosphonate Pathway, Pharmacodynamics
	Statin Pathway, Pharmacodynamics

2 Kegg Pathways (Kegg details for SQLE):

	Steroid biosynthesis
	Metabolic pathways

UniProtKB/Swiss-Prot: ERG1_HUMAN, Q14534

Pathway: Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 2/3

SQLE for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SQLE

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/65 Interacting proteins for SQLE (Q14534³ ENSP00000265896⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 65)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DNM1L	O00429³, ENSP00000266481⁴	I2D: score=1 STRING: ENSP00000266481
SC5DL	O75845³, ENSP00000264027⁴	I2D: score=1 STRING: ENSP00000264027
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=3 STRING: ENSP00000344818
MSMO1	Q15800³, ENSP00000261507⁴	I2D: score=2 STRING: ENSP00000261507
CYP51A1	Q16850³, ENSP00000003100⁴	I2D: score=1 STRING: ENSP00000003100

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006695	cholesterol biosynthetic process	TAS	--
GO:0006725	cellular aromatic compound metabolic process	IEA	--
GO:0008203	cholesterol metabolic process	--	--
GO:0010033	response to organic substance	IEA	--
GO:0016126	sterol biosynthetic process	NAS	9286711

SQLE for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SQLE for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for SQLE

Browse Tocris compounds for SQLE

4 HMDB Compounds for SQLE About this table

Compound	Synonyms	CAS #	PubMed Ids
FAD	1H-Purin-6-amine flavin dinucleotide (see all 21)	146-14-5	--
Ferricytochrome	553-12-8 (FREE ACID) (see all 21)	1818-68-4	--
Ferrocytochrome	553-12-8 (FREE ACID) (see all 21)	1818-68-4	--
Squalene	(E,E,E,E)-Squalene (see all 10)	111-02-4	--

3 DrugBank Compounds for SQLE About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Terbinafine	Terbinafine HCl (see all 3)	91161-71-6	target	inhibitor	1543672 14638499 11752352 19874252 12226513 12100530 12477372 12963042
Butenafine	Butenafina [INN-Spanish] (see all 5)	101828-21-1	target	inhibitor	18624686 12499173 11752352 8494375 16079485 17642865
Naftifine	--	65472-88-0	target	inhibitor	3877503 12499173 11752352 8834895 1287164 1951574

10/25 Novoseek chemical compound relationships for SQLE gene (see all 25) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
squalene	97.1	160	1964954 (7), 11181753 (6), 9324936 (5), 9300786 (4) (see all 75)
naftifine	91.2	3	17896810 (1), 1951574 (1), 12499173 (1)
dimethyltelluride	89	1	11181753 (1)
terbinafine	87.5	31	15980358 (5), 15682641 (2), 16466954 (2), 15215099 (2) (see all 16)
ergosterol	84.8	17	18096502 (2), 12477372 (2), 16466954 (2), 1287164 (1) (see all 10)
lanosterol	81.1	5	16079485 (1), 7791529 (1), 15893902 (1)
butenafine	78.4	2	16079485 (1), 12499173 (1)
tolnaftate	78.4	1	12499173 (1)
sterol	74.5	11	8626488 (1), 7791529 (1), 19680554 (1), 1803242 (1) (see all 9)
tellurium	67.4	9	11181753 (5), 8090356 (1)

Search CenterWatch for drugs/clinical trials and news about SQLE / ERG1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SQLE gene:

NM_003129.3

Unigene Cluster for SQLE:

Squalene epoxidase

Hs.71465 [show with all ESTs]

Unigene Representative Sequence: NM_003129

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000523430 ENST00000265896(uc011liq.2) ENST00000521232 ENST00000518931

ENST00000520493 ENST00000518604

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SQLE
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		hsa-miR-579 hsa-miR-518a-5p hsa-miR-664
		SwitchGear 3'UTR luciferase reporter plasmid: SQLE 3' UTR sequence

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		Sirion Biotech Custom design and validation of potent shRNA sequences against SQLE

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SQLE

Additional cDNA sequence:

AF098865.1 AK225085.1 AK295302.1 AK301792.1 AK313384.1 BC017033.1 BX647400.1 BX647605.1

D78129.1 D78130.1

10 DOTS entries:

DT.97857247 DT.117824 DT.40299615 DT.95210936 DT.100757709 DT.92441125 DT.95210960 DT.75155650

DT.92441126 DT.95210930

24/265 AceView cDNA sequences (see all 265):

BU631333 F05344 AA580614 AI802289 BF154931 AI084342 AI341546 W80742

AU125689 BI439805 AU102597 BC017033 AA132213 BI324843 AK055357 BM790548

AL041945 AI937469 BU161548 AU136459 AW170130 Z38352 BU839482 BM683292

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SQLE expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAAATAAAAT

About this image

SQLE expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Head Mesenchyme

Branchial Arch 1

Cranial Neural Crest Cells

Neural Crest

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Mature follicles (In-vitro growth and ...)

See SQLE Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SQLE

SOURCE GeneReport for Unigene cluster: Hs.71465

SABiosciences Custom PCR Arrays for SQLE

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SQLE Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SQLE

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SQLE

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SQLE gene from 7/26 species (see all 26) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Sqle^{1 , 5}	squalene epoxidase^{1, 5}	82.98(n)¹ 84.44(a)¹		15 (25.16 cM)⁵ 20775¹ NM_009270.3¹ NP_033296.1¹ 59315077⁵
chicken (Gallus gallus)	Aves	SQLE¹	squalene epoxidase	73.71(n) 71.73(a)		420335 NM_001194927.1 NP_001181856.1
lizard (Anolis carolinensis)	Reptilia	SQLE⁶	--	68(a)	1 ↔ 1	4(5776135-5806059)
zebrafish (Danio rerio)	Actinopterygii	zgc:171801¹	zgc:171801	64.98(n) 65.59(a)		799528 NM_001110039.1 NP_001103509.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	ERG1(YGR175C)⁴ ERG1¹	Squalene epoxidase, catalyzes the epoxidation of squalene more⁴ Erg1p¹	49.62(n)¹ 40(a)¹		7(848423-846933)⁴ 853086^{1, 4} NP_011691.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	XF1¹	squalene monooxygenase	50.59(n) 44.91(a)		842213 NM_104624.3 NP_564734.1
rice (Oryza sativa)	Liliopsida	Os.20969²	Oryza sativa (japonica cultivar-group) cDNA cloneJ more	75.66(n)		AK065032.1

ENSEMBL Gene Tree for SQLE (if available)
TreeFam Gene Tree for SQLE (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SQLE gene

2 SIMAP similar genes for SQLE using alignment to 4 protein entries: ERG1_HUMAN (see all proteins):

ERG1 DKFZp686B0215

SQLE for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for SQLE
PGOHUM00000257216

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs190628265^1,2		--	126008790(+)	`CAGAGC/TGAGAC`	1	--	us2k¹		0	--	--	--	--
rs7815271^1,2	C	--	126008885(+)	`CAGTTT/CATTGA`	1	--	us2k¹		2		WA	120
rs148028510^1,2		--	126008966(+)	`ATGTCA/CGTTCA`	1	--	us2k¹		0	--	--	--	--
rs3763545^1,2	C	--	126009021(+)	`AGAATA/GAAAGT`	1	--	us2k¹		4		WA NA EA	360
rs182492721^1,2		--	126009106(+)	`TTTGGC/TTTCAT`	1	--	us2k¹		0	--	--	--	--
rs141753736^1,2		--	126009368(+)	`AGTTGC/GCTTCT`	1	--	us2k¹		0	--	--	--	--
rs78683702^1,2	F	--	126009595(+)	`ATCTAG/AAGATT`	1	--	us2k¹		1		WA	118
rs75896419^1,2	F	--	126009675(+)	`AGCCAC/AGCTCC`	1	--	us2k¹		1		WA	118
rs3853255^1,2	C,F,A,H	--	126009831(-)	`AGTCTC/TGGAGT`	1	--	us2k¹		13		NS EA NA WA	1488
rs150587294^1,2		--	126009853(+)	`TTGCTA/CCCTCG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SQLE (126010720 - 126034525 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SQLE: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SQLE

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SQLE for disorders           About GeneDecksing

OMIM gene information: 602019    OMIM disorders: --

14 diseases for SQLE:    About MalaCards

tinea cruris candida glabrata tinea pedis pityriasis versicolor

tinea capitis squamous cell carcinoma lung squamous cell carcinoma hypercholesterolemia

breast cancer obesity carcinoma cholesterol

pancreatitis neuronitis

3 Novoseek disease relationships for SQLE gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
infection fungal	36	2	17531123 (1), 12956204 (1)
demyelination	30	1	11181753 (1)
hypercholesterolemia	28	1	1649182 (1)

Human Genome Epidemiology (HuGE) Navigator: SQLE (5 documents)

Export disorders for SQLE gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SQLE gene, integrated from 9 sources (see all 106):
(articles sorted by number of sources associating them with SQLE)

Utopia: connect your pdf to the dynamic
world of online information

Localization of the squalene epoxidase gene (SQLE) to human chromosome region 8q24.1. (PubMed id 9286711)^{1, 2, 3, 9} Nagai M.... Ono T. (1997)
Transcriptional regulation of squalene epoxidase by sterols and inhibitors in HeLa cells. (PubMed id 8626488)^{1, 2, 9} Nakamura Y.... Ono T. (1996)
Squalene epoxidase, located on chromosome 8q24.1, is upregulated in 8q+ breast cancer and indicates poor clinical outcome in stage I and II disease. (PubMed id 18728668)^{1, 9} Helms M.W....Brandt B.H. (2008)
Cloning, heterologous expression, and enzymological characterization of human squalene monooxygenase. (PubMed id 10666321)^{1, 9} Laden B.P....Porter T.D. (2000)
Terbinafine: a review of its use in onychomycosis in adults. (PubMed id 12477372)^{7, 9} Darkes M.J....Goa K.L. (2003)
Mode of action of anti-Candida drugs: focus on terconazole and other ergosterol biosynthesis inhibitors. (PubMed id 1951574)^{7, 9} Vanden Bossche H. and Marichal P. (1991)
In vitro antifungal activity of ZJ-522, a new triazole restructured from fluconazole and butenafine, against clinically important fungi in comparison with fluconazole and butenafine. (PubMed id 16079485)^{7, 9} Gao P.H....Jiang Y.Y. (2005)
Clinical Trichophyton rubrum strain exhibiting primary resistance to terbinafine. (PubMed id 12499173)^{7, 9} Mukherjee P.K....Ghannoum M.A. (2003)
Interaction of terbinafine with human serum and serum proteins. (PubMed id 1287164)^{7, 9} Ryder N.S. and Frank I. (1992)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6713	HGNC: 11279	AceView: SQLE	Ensembl:ENSG00000104549	euGenes: HUgn6713
ECgene: SQLE	Kegg: 6713	H-InvDB: SQLE

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SQLE	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SQLE gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SQLE gene:
Search GeneIP for patents involving SQLE

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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