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Aliases for SQLE Gene

Aliases for SQLE Gene

  • Squalene Epoxidase 2 3 4
  • Squalene Monooxygenase 2 3
  • SE 3 4
  • EC 4
  • ERG1 4

External Ids for SQLE Gene

Summaries for SQLE Gene

Entrez Gene Summary for SQLE Gene

  • Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting enzymes in this pathway. [provided by RefSeq, Jul 2008]

GeneCards Summary for SQLE Gene

SQLE (Squalene Epoxidase) is a Protein Coding gene. Diseases associated with SQLE include tinea cruris and tinea pedis. Among its related pathways are Regulation of Cholesterol Biosynthesis by SREBP (SREBF) and Metabolism. GO annotations related to this gene include flavin adenine dinucleotide binding and squalene monooxygenase activity.

UniProtKB/Swiss-Prot for SQLE Gene

  • Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway

Gene Wiki entry for SQLE Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SQLE Gene

Genomics for SQLE Gene

Genomic Location for SQLE Gene

124,998,478 bp from pter
125,022,283 bp from pter
23,806 bases
Plus strand

Genomic View for SQLE Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SQLE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SQLE Gene

Regulatory Elements for SQLE Gene

Proteins for SQLE Gene

  • Protein details for SQLE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Squalene monooxygenase
    Protein Accession:
    Secondary Accessions:
    • Q9UEK6

    Protein attributes for SQLE Gene

    574 amino acids
    Molecular mass:
    63923 Da
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • May form a complex with squalene synthase

neXtProt entry for SQLE Gene

Proteomics data for SQLE Gene at MOPED

Post-translational modifications for SQLE Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys90, Lys290, Lys426, and Lys436

Other Protein References for SQLE Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SQLE Gene

Domains for SQLE Gene

Protein Domains for SQLE Gene


  • Belongs to the squalene monooxygenase family.:
    • Q14534
genes like me logo Genes that share domains with SQLE: view

No data available for Gene Families for SQLE Gene

Function for SQLE Gene

Molecular function for SQLE Gene

GENATLAS Biochemistry: squalene epoxidase catalyzing the first oxygenation step in sterol biosynthesis
UniProtKB/Swiss-Prot CatalyticActivity: Squalene + NADPH + O(2) = (3S)-2,3-epoxy-2,3-dihydrosqualene + NADP(+) + H(2)O
UniProtKB/Swiss-Prot Function: Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway

Enzyme Numbers (IUBMB) for SQLE Gene

Gene Ontology (GO) - Molecular Function for SQLE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004506 squalene monooxygenase activity TAS --
GO:0016491 oxidoreductase activity --
GO:0050660 flavin adenine dinucleotide binding IEA --
genes like me logo Genes that share ontologies with SQLE: view
genes like me logo Genes that share phenotypes with SQLE: view

miRNA for SQLE Gene

miRTarBase miRNAs that target SQLE

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for SQLE Gene

Localization for SQLE Gene

Subcellular locations from UniProtKB/Swiss-Prot for SQLE Gene

Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SQLE Gene COMPARTMENTS Subcellular localization image for SQLE gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
cytosol 1
extracellular 1
golgi apparatus 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SQLE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle --
genes like me logo Genes that share ontologies with SQLE: view

Pathways for SQLE Gene

genes like me logo Genes that share pathways with SQLE: view

UniProtKB/Swiss-Prot Q14534-ERG1_HUMAN

  • Pathway: Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 2/3

Gene Ontology (GO) - Biological Process for SQLE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006695 cholesterol biosynthetic process TAS --
GO:0006725 cellular aromatic compound metabolic process IEA --
GO:0008203 cholesterol metabolic process --
GO:0010033 response to organic substance IEA --
GO:0016126 sterol biosynthetic process NAS 9286711
genes like me logo Genes that share ontologies with SQLE: view

Compounds for SQLE Gene

(4) HMDB Compounds for SQLE Gene

Compound Synonyms Cas Number PubMed IDs
  • 1H-Purin-6-amine flavin dinucleotide
  • 553-12-8 (FREE ACID)
  • 553-12-8 (FREE ACID)
  • (E,E,E,E)-Squalene

(4) Drugbank Compounds for SQLE Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
  • Butenafina [INN-Spanish]
101828-21-1 target inhibitor
Ellagic Acid
476-66-4 target inhibitor
65472-88-0 target inhibitor
  • Terbinafine HCl
91161-71-6 target inhibitor

(25) Novoseek inferred chemical compound relationships for SQLE Gene

Compound -log(P) Hits PubMed IDs
squalene 97.1 129
naftifine 91.2 3
dimethyltelluride 89 1
terbinafine 87.5 23
ergosterol 84.8 13
genes like me logo Genes that share compounds with SQLE: view

Transcripts for SQLE Gene

Unigene Clusters for SQLE Gene

Squalene epoxidase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SQLE Gene

No ASD Table

Relevant External Links for SQLE Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SQLE Gene

mRNA expression in normal human tissues for SQLE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SQLE Gene

This gene is overexpressed in Esophagus - Mucosa (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SQLE Gene

SOURCE GeneReport for Unigene cluster for SQLE Gene Hs.71465

genes like me logo Genes that share expressions with SQLE: view

Orthologs for SQLE Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SQLE Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SQLE 36
  • 99.48 (n)
  • 99.3 (a)
  • 99 (a)
(Bos Taurus)
Mammalia SQLE 36
  • 89.04 (n)
  • 87.94 (a)
  • 88 (a)
(Canis familiaris)
Mammalia SQLE 36
  • 88.42 (n)
  • 87.78 (a)
  • 88 (a)
(Mus musculus)
Mammalia Sqle 36
  • 82.98 (n)
  • 84.44 (a)
Sqle 16
Sqle 37
  • 84 (a)
(Monodelphis domestica)
Mammalia SQLE 37
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia SQLE 37
  • 78 (a)
(Rattus norvegicus)
Mammalia Sqle 36
  • 83.01 (n)
  • 83.94 (a)
(Gallus gallus)
Aves SQLE 36
  • 73.71 (n)
  • 71.73 (a)
  • 72 (a)
(Anolis carolinensis)
Reptilia SQLE 37
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sqle 36
  • 67.21 (n)
  • 68.35 (a)
(Danio rerio)
Actinopterygii sqlea 36
  • 65.17 (n)
  • 65.77 (a)
sqlea 37
  • 65 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL141C 36
  • 45.93 (n)
  • 36.65 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERG1 36
  • 49.62 (n)
  • 40 (a)
ERG1 37
  • 36 (a)
ERG1 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F15224g 36
  • 49.18 (n)
  • 38.84 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.9714 36
thale cress
(Arabidopsis thaliana)
eudicotyledons XF1 36
  • 50.72 (n)
  • 45.13 (a)
(Zea mays)
Liliopsida Zm.7407 36
(Oryza sativa)
Liliopsida Os.20969 36
Os03g0231700 36
  • 51.91 (n)
  • 47.08 (a)
(Triticum aestivum)
Liliopsida Ta.7591 36
bread mold
(Neurospora crassa)
Ascomycetes NCU08280 36
  • 47.52 (n)
  • 45.05 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes erg1 36
  • 50.04 (n)
  • 43.62 (a)
Species with no ortholog for SQLE:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)

Evolution for SQLE Gene

Gene Tree for SQLE (if available)
Gene Tree for SQLE (if available)

Paralogs for SQLE Gene

Selected SIMAP similar genes for SQLE Gene using alignment to 4 proteins: Pseudogenes for SQLE Gene

genes like me logo Genes that share paralogs with SQLE: view

No data available for Paralogs for SQLE Gene

Variants for SQLE Gene

Sequence variations from dbSNP and Humsavar for SQLE Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs9940 -- 125,022,168(+) CATTT(A/G)AAAGA utr-variant-3-prime
rs15905 -- 124,998,563(+) CTGGG(C/G)CCGCG utr-variant-5-prime
rs966945 -- 125,018,482(+) GGTGA(C/T)TTTTT intron-variant
rs966946 -- 125,018,567(+) GGGGA(C/T)TATAA intron-variant
rs1048852 -- 124,999,395(+) GAAGC(C/G)TTGGA utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SQLE Gene

Variant ID Type Subtype PubMed ID
nsv891434 CNV Gain 21882294
esv268241 CNV Insertion 20981092
esv274006 CNV Insertion 20981092

Relevant External Links for SQLE Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for SQLE Gene

(3) University of Copenhagen DISEASES for SQLE Gene

(3) Novoseek inferred disease relationships for SQLE Gene

Disease -log(P) Hits PubMed IDs
infection fungal 36 2
demyelination 30 1
hypercholesterolemia 28 1

Relevant External Links for SQLE

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SQLE: view

No data available for UniProtKB/Swiss-Prot for SQLE Gene

Publications for SQLE Gene

  1. Localization of the squalene epoxidase gene (SQLE) to human chromosome region 8q24.1. (PMID: 9286711) Nagai M. … Ono T. (Genomics 1997) 2 3 4 23
  2. Transcriptional regulation of squalene epoxidase by sterols and inhibitors in HeLa cells. (PMID: 8626488) Nakamura Y. … Ono T. (J. Biol. Chem. 1996) 3 4 23
  3. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PMID: 18660489) Lu Y. … Boer J.M. (J. Lipid Res. 2008) 3 49
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 49
  5. Squalene epoxidase, located on chromosome 8q24.1, is upregulated in 8q+ breast cancer and indicates poor clinical outcome in stage I and II disease. (PMID: 18728668) Helms M.W. … Brandt B.H. (Br. J. Cancer 2008) 3 23

Products for SQLE Gene

Sources for SQLE Gene

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