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Aliases for SPZ1 Gene

Aliases for SPZ1 Gene

  • Spermatogenic Leucine Zipper 1 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 148 2 3
  • Testis-Specific Protein 1 3 4
  • Testis Secretory Sperm-Binding Protein Li 232m 3
  • Spermatogenic Leucine Zipper Protein 1 3
  • Testis-Specific Protein NYD-TSP1 4
  • Spermatogenic Zip 1 3
  • NYD-TSP1 3
  • PPP1R148 3
  • TSP1 4

External Ids for SPZ1 Gene

Previous GeneCards Identifiers for SPZ1 Gene

  • GC05P079651
  • GC05P074823

Summaries for SPZ1 Gene

Entrez Gene Summary for SPZ1 Gene

  • This gene encodes a bHLH-zip transcription factor which functions in the mitogen-activate protein kinase (MAPK) signaling pathway. Because of its role in the upregulation of cell proliferation and tumorigenesis, this gene may serve as a target for Ras-induced tumor treatments. [provided by RefSeq, Oct 2011]

GeneCards Summary for SPZ1 Gene

SPZ1 (Spermatogenic Leucine Zipper 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity.

UniProtKB/Swiss-Prot for SPZ1 Gene

  • Transcription factor that binds to the DNA sequence 5-CANNTG-3(E box) and the G-box motif. May play an important role in the regulation of cell proliferation and differentiation during spermatogenesis (By similarity).

Gene Wiki entry for SPZ1 Gene

Additional gene information for SPZ1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPZ1 Gene

Genomics for SPZ1 Gene

GeneHancer (GH) Regulatory Elements for SPZ1 Gene

Promoters and enhancers for SPZ1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I080319 Promoter 0.5 EPDnew 550.8 +0.4 360 0.1 SPZ1 RBMX2P5
GH05I080573 Enhancer 0.2 FANTOM5 14.2 +253.8 253780 0.1 ANKRD34B SPZ1 DBIP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPZ1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPZ1 gene promoter:

Genomic Locations for SPZ1 Gene

Genomic Locations for SPZ1 Gene
2,218 bases
Plus strand

Genomic View for SPZ1 Gene

Genes around SPZ1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPZ1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPZ1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPZ1 Gene

Proteins for SPZ1 Gene

  • Protein details for SPZ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Spermatogenic leucine zipper protein 1
    Protein Accession:
    Secondary Accessions:
    • B2RA21
    • Q8N4P1
    • Q8N7E9

    Protein attributes for SPZ1 Gene

    430 amino acids
    Molecular mass:
    49445 Da
    Quaternary structure:
    • Interacts with PPP1CC isoform gamma-2.
    • The helix-loop-helix and basic motifs form a SPZ1 specific bHLH different from the classical one.
    • Sequence=BAC05340.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

neXtProt entry for SPZ1 Gene

Post-translational modifications for SPZ1 Gene

Other Protein References for SPZ1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPZ1 Gene

Domains & Families for SPZ1 Gene

Gene Families for SPZ1 Gene

Protein Domains for SPZ1 Gene


Suggested Antigen Peptide Sequences for SPZ1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPZ1: view

No data available for UniProtKB/Swiss-Prot for SPZ1 Gene

Function for SPZ1 Gene

Molecular function for SPZ1 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that binds to the DNA sequence 5-CANNTG-3(E box) and the G-box motif. May play an important role in the regulation of cell proliferation and differentiation during spermatogenesis (By similarity).

Gene Ontology (GO) - Molecular Function for SPZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SPZ1: view
genes like me logo Genes that share phenotypes with SPZ1: view

miRNA for SPZ1 Gene

miRTarBase miRNAs that target SPZ1

Transcription Factor Targets for SPZ1 Gene

Selected GeneGlobe predicted Target genes for SPZ1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models and HOMER Transcription for SPZ1 Gene

Localization for SPZ1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPZ1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPZ1 gene
Compartment Confidence
nucleus 4
cytosol 2
golgi apparatus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for SPZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SPZ1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SPZ1 Gene

Pathways & Interactions for SPZ1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with SPZ1: view

No data available for Pathways by source and SIGNOR curated interactions for SPZ1 Gene

Drugs & Compounds for SPZ1 Gene

No Compound Related Data Available

Transcripts for SPZ1 Gene

mRNA/cDNA for SPZ1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(23) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPZ1 Gene

Spermatogenic leucine zipper 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPZ1 Gene

No ASD Table

Relevant External Links for SPZ1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPZ1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPZ1 Gene

mRNA differential expression in normal tissues according to GTEx for SPZ1 Gene

This gene is overexpressed in Testis (x52.6).

Protein differential expression in normal tissues from HIPED for SPZ1 Gene

This gene is overexpressed in Fetal Liver (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPZ1 Gene

Protein tissue co-expression partners for SPZ1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SPZ1 Gene:


SOURCE GeneReport for Unigene cluster for SPZ1 Gene:


mRNA Expression by UniProt/SwissProt for SPZ1 Gene:

Tissue specificity: Specifically and strongly expressed in the testis. Expressed in several tumor cell lines.

Evidence on tissue expression from TISSUES for SPZ1 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with SPZ1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPZ1 Gene

Orthologs for SPZ1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPZ1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPZ1 33
  • 98.6 (n)
(Canis familiaris)
Mammalia SPZ1 33 34
  • 81.78 (n)
(Bos Taurus)
Mammalia SPZ1 33 34
  • 77.45 (n)
(Mus musculus)
Mammalia Spz1 33 16 34
  • 66.93 (n)
(Rattus norvegicus)
Mammalia Spz1 33
  • 65.17 (n)
Species where no ortholog for SPZ1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPZ1 Gene

Gene Tree for SPZ1 (if available)
Gene Tree for SPZ1 (if available)

Paralogs for SPZ1 Gene

No data available for Paralogs for SPZ1 Gene

Variants for SPZ1 Gene

Sequence variations from dbSNP and Humsavar for SPZ1 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1001711896 -- 80,318,851(+) C/T upstream_transcript_variant
rs1002556609 -- 80,319,564(+) G/A upstream_transcript_variant
rs1003458873 -- 80,320,808(+) A/G coding_sequence_variant, missense_variant
rs1004436420 -- 80,321,052(+) T/A coding_sequence_variant, missense_variant
rs1005437095 -- 80,319,213(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SPZ1 Gene

Variant ID Type Subtype PubMed ID
dgv1108e214 CNV gain 21293372
esv3605566 CNV loss 21293372
esv3605567 CNV gain 21293372
nsv518480 CNV gain 19592680

Variation tolerance for SPZ1 Gene

Residual Variation Intolerance Score: 94.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.46; 54.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPZ1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPZ1 Gene

Disorders for SPZ1 Gene

Additional Disease Information for SPZ1

No disorders were found for SPZ1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPZ1 Gene

Publications for SPZ1 Gene

  1. bHLH-zip transcription factor Spz1 mediates mitogen-activated protein kinase cell proliferation, transformation, and tumorigenesis. (PMID: 15899793) Hsu SH … Li H (Cancer research 2005) 2 3 4 58
  2. Expression of a novel bHLH-Zip gene in human testis. (PMID: 12778315) Sha JH … Zhou KY (Asian journal of andrology 2003) 2 3 4 58
  3. Patterns of expression of sperm flagellar genes: early expression of genes encoding axonemal proteins during the spermatogenic cycle and shared features of promoters of genes encoding central apparatus proteins. (PMID: 15829580) Horowitz E … Strauss JF (Molecular human reproduction 2005) 2 3 58
  4. Identification of the spermatogenic zip protein Spz1 as a putative protein phosphatase-1 (PP1) regulatory protein that specifically binds the PP1cgamma2 splice variant in mouse testis. (PMID: 15226296) Hrabchak C … Varmuza S (The Journal of biological chemistry 2004) 2 3 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for SPZ1 Gene

Sources for SPZ1 Gene

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