SPZ1 Gene
protein-coding GIFtS: 40
GCID: GC05P079651
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spermatogenic leucine zipper 1
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Aliases
for SPZ1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Spermatogenic Leucine Zipper 11 2 | | Spermatogenic Leucine Zipper Protein 12 | | NYD-TSP11 2 | | Spermatogenic Zip 12 | | Testis-Specific Protein 12 3 | | TSP13 | | FLJ257091 | | Testis-Specific Protein NYD-TSP13 |
Export aliases for SPZ1 gene to outside databasesPrevious GC identifer: GC05P074823 |
Summaries
for SPZ1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SPZ1:
This gene encodes a bHLH-zip transcription factor which functions in the mitogen-activate protein kinase (MAPK)signaling pathway. Because of its role in the upregulation of cell proliferation and tumorigenesis, this gene mayserve as a target for Ras-induced tumor treatments. (provided by RefSeq, Oct 2011)
UniProtKB/Swiss-Prot: SPZ1_HUMAN, Q9BXG8Function: Transcription factor that binds to the DNA sequence 5'-CANNTG-3'(E box) and the G-box motif. May play animportant role in the regulation of cell proliferation and differentiation during spermatogenesis (By similarity)
Gene Wiki entry for SPZ1
|
Genomic Views
for SPZ1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_006713.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SPZ1 gene promoter:
RORalpha1 ER-alpha HOXA3 AML1a Sox9 ZID LCR-F1 C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPZ1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPZ1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q14.1 Ensembl cytogenetic band: 5q14.1 HGNC cytogenetic band: 5q14.1SPZ1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P079651: view genomic region
(about GC identifiers)
Start:
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79,615,444 bp from pter |
End:
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79,617,661 bp from pter |
Size:
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2,218 bases |
Orientation:
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plus strand |
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Proteins
for SPZ1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPZ1_HUMAN, Q9BXG8 (See
protein sequence)Recommended Name: Spermatogenic leucine zipper protein 1 Size: 430 amino acids; 49445 Da
Subunit: Interacts with PPP1CC isoform gamma-2 (By similarity)
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)
Miscellaneous: The helix-loop-helix and basic motifs form a SPZ1 specific bHLH different from the classical one (Bysimilarity)
Sequence caution: Sequence=BAC05340.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
Secondary accessions: B2RA21 Q8N4P1 Q8N7E9Explore the universe of human proteins at neXtProt for SPZ1: NX_Q9BXG8
Post-translational modifications:
Phosphorylated by MAPK1/ERK2 and MAPK3/ERK1 (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BXG8
SPZ1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115956.3
ENSEMBL proteins: ENSP00000426530 ENSP00000369611
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SPZ1 for ontologies About GeneDecksing
SPZ1 Antibody Products:
Assay Products for SPZ1: |
Protein
Domains /
Families
for SPZ1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9BXG8 |
Function
for SPZ1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SPZ1_HUMAN, Q9BXG8Function: Transcription factor that binds to the DNA sequence 5'-CANNTG-3'(E box) and the G-box motif. May play animportant role in the regulation of cell proliferation and differentiation during spermatogenesis (By similarity)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPZ1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPZ1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- |
SPZ1 for ontologies About GeneDecksing
|
Pathways & Interactions
for SPZ1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPZ1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for SPZ1 (Q9BXG83 ENSP000003696114) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
SPZ1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SPZ1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SPZ1
Search CenterWatch for drugs/clinical trials and news about SPZ1
|
Transcripts
for SPZ1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPZ1 gene: NM_032567.3 Unigene Cluster for SPZ1: Spermatogenic leucine zipper 1 Hs.519403 [show with all ESTs]Unigene Representative Sequence: BC0337982 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000511881 ENST00000296739(uc003kgn.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPZ1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPZ1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SPZ1 (NM_032567) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPZ1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPZ1 |
Additional cDNA sequence: AF333098.1 AK098575.1 AK314007.1 BC033798.1 2 DOTS entries: DT.40119296 DT.100749447 1 AceView cDNA sequence: AK098575
GeneLoc Exon Structure
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Expression
for SPZ1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPZ1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGCAAGAAA
About this image
See SPZ1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPZ1
SOURCE GeneReport for Unigene cluster: Hs.519403
UniProtKB/Swiss-Prot: SPZ1_HUMAN, Q9BXG8Tissue specificity: Specifically and strongly expressed in the testis. Expressed in several tumor cell lines
SABiosciences Custom PCR Arrays for SPZ1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPZ1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPZ1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPZ1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPZ1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPZ1 |
Orthologs
for SPZ1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for SPZ1 gene from 1/5 species (see all 5) About this table
ENSEMBL Gene Tree for SPZ1 (if available)
TreeFam Gene Tree for SPZ1 (if available) |
Paralogs
for SPZ1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SPZ1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SPZ1 (79615444 - 79617661 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SPZ1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPZ1 |
|
Disorders
/ Diseases
for SPZ1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for SPZ1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPZ1 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with SPZ1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- bHLH-zip transcription factor Spz1 mediates mitogen-activated protein kinase cell proliferation, transformation, and tumorigenesis. (PubMed id 15899793)1, 2, 3 Hsu S.-H.... Li H. (2005)
- Expression of a novel bHLH-Zip gene in human testis. (PubMed id 12778315)1, 2, 3 Sha J.-H.... Zhou K.-Y. (2003)
- Patterns of expression of sperm flagellar genes: earl y expression of genes encoding axonemal proteins during the spermatogenic cycle and shared features of promoters of genes encoding central apparatus proteins. (PubMed id 15829580)1, 3 Horowitz E....Strauss J.F. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)1, 2 Schmutz J.... Rubin E.M. (2004)
- Identification of the spermatogenic zip protein Spz1 as a putative protein phosphatase-1 (PP1) regulatory protein that specifically binds the PP1cgamma2 splice variant in mouse testis. (PubMed id 15226296)1, 3 Hrabchak C. and Varmuza S. (2004)
- Spz1, a novel bHLH-Zip protein, is specifically expressed in testis. (PubMed id 11165476)1, 3 Hsu S.H....Li H. (2001)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
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External Searches for SPZ1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing SPZ1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SPZ1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPZ1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SPZ1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SPZ1 gene:
Search GeneIP for patents involving SPZ1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SPZ1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SPZ1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPZ1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPZ1 | | | OriGene Protein Over-expression Lysate for SPZ1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SPZ1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPZ1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPZ1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SPZ1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | SPZ1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPZ1 |
|  |  |  | | | | ThermoFisher Antibodies for SPZ1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPZ1 |
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