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Aliases for SPZ1 Gene

Aliases for SPZ1 Gene

  • Spermatogenic Leucine Zipper 1 2 3 5
  • Testis-Specific Protein 1 3 4
  • Testis Secretory Sperm-Binding Protein Li 232m 3
  • Protein Phosphatase 1, Regulatory Subunit 148 3
  • Testis-Specific Protein NYD-TSP1 4
  • Regulatory Subunit 148 2
  • Protein Phosphatase 1 2
  • Spermatogenic Zip 1 3
  • NYD-TSP1 3
  • PPP1R148 3
  • TSP1 4

External Ids for SPZ1 Gene

Previous GeneCards Identifiers for SPZ1 Gene

  • GC05P079651
  • GC05P074823

Summaries for SPZ1 Gene

Entrez Gene Summary for SPZ1 Gene

  • This gene encodes a bHLH-zip transcription factor which functions in the mitogen-activate protein kinase (MAPK) signaling pathway. Because of its role in the upregulation of cell proliferation and tumorigenesis, this gene may serve as a target for Ras-induced tumor treatments. [provided by RefSeq, Oct 2011]

GeneCards Summary for SPZ1 Gene

SPZ1 (Spermatogenic Leucine Zipper 1) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding.

UniProtKB/Swiss-Prot for SPZ1 Gene

  • Transcription factor that binds to the DNA sequence 5-CANNTG-3(E box) and the G-box motif. May play an important role in the regulation of cell proliferation and differentiation during spermatogenesis (By similarity).

Gene Wiki entry for SPZ1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPZ1 Gene

Genomics for SPZ1 Gene

Regulatory Elements for SPZ1 Gene

Enhancers for SPZ1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SPZ1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPZ1 Gene

80,319,625 bp from pter
80,321,842 bp from pter
2,218 bases
Plus strand

Genomic View for SPZ1 Gene

Genes around SPZ1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPZ1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPZ1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPZ1 Gene

Proteins for SPZ1 Gene

  • Protein details for SPZ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Spermatogenic leucine zipper protein 1
    Protein Accession:
    Secondary Accessions:
    • B2RA21
    • Q8N4P1
    • Q8N7E9

    Protein attributes for SPZ1 Gene

    430 amino acids
    Molecular mass:
    49445 Da
    Quaternary structure:
    • Interacts with PPP1CC isoform gamma-2.
    • The helix-loop-helix and basic motifs form a SPZ1 specific bHLH different from the classical one.
    • Sequence=BAC05340.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

neXtProt entry for SPZ1 Gene

Proteomics data for SPZ1 Gene at MOPED

Post-translational modifications for SPZ1 Gene

Other Protein References for SPZ1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPZ1 Gene

Domains & Families for SPZ1 Gene

Gene Families for SPZ1 Gene

Protein Domains for SPZ1 Gene


Suggested Antigen Peptide Sequences for SPZ1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPZ1: view

No data available for UniProtKB/Swiss-Prot for SPZ1 Gene

Function for SPZ1 Gene

Molecular function for SPZ1 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that binds to the DNA sequence 5-CANNTG-3(E box) and the G-box motif. May play an important role in the regulation of cell proliferation and differentiation during spermatogenesis (By similarity).

Gene Ontology (GO) - Molecular Function for SPZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SPZ1: view
genes like me logo Genes that share phenotypes with SPZ1: view

Animal Model Products

miRNA for SPZ1 Gene

miRTarBase miRNAs that target SPZ1

Transcription Factor Targets for SPZ1 Gene

Selected GeneGlobe predicted Target genes for SPZ1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and HOMER Transcription for SPZ1 Gene

Localization for SPZ1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPZ1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for SPZ1 Gene COMPARTMENTS Subcellular localization image for SPZ1 gene
Compartment Confidence
nucleus 4
cytosol 2
golgi apparatus 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for SPZ1 Gene

Pathways & Interactions for SPZ1 Gene

SuperPathways for SPZ1 Gene

No Data Available

Interacting Proteins for SPZ1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000369611 Q9BXG8-SPZ1_HUMAN for SPZ1 Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for SPZ1 Gene


No data available for Pathways by source and SIGNOR curated interactions for SPZ1 Gene

Drugs & Compounds for SPZ1 Gene

No Compound Related Data Available

Transcripts for SPZ1 Gene

mRNA/cDNA for SPZ1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPZ1 Gene

Spermatogenic leucine zipper 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPZ1 Gene

No ASD Table

Relevant External Links for SPZ1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPZ1 Gene

mRNA expression in normal human tissues for SPZ1 Gene

mRNA differential expression in normal tissues according to GTEx for SPZ1 Gene

This gene is overexpressed in Testis (x52.6).

Protein differential expression in normal tissues from HIPED for SPZ1 Gene

This gene is overexpressed in Fetal Liver (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPZ1 Gene

SOURCE GeneReport for Unigene cluster for SPZ1 Gene Hs.519403

mRNA Expression by UniProt/SwissProt for SPZ1 Gene

Tissue specificity: Specifically and strongly expressed in the testis. Expressed in several tumor cell lines.
genes like me logo Genes that share expression patterns with SPZ1: view

Protein tissue co-expression partners for SPZ1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SPZ1 Gene

Orthologs for SPZ1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPZ1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SPZ1 35
  • 77.45 (n)
  • 59.24 (a)
SPZ1 36
  • 59 (a)
(Canis familiaris)
Mammalia SPZ1 35
  • 81.78 (n)
  • 66.57 (a)
SPZ1 36
  • 65 (a)
(Mus musculus)
Mammalia Spz1 35
  • 66.93 (n)
  • 49.34 (a)
Spz1 16
Spz1 36
  • 48 (a)
(Pan troglodytes)
Mammalia SPZ1 35
  • 98.6 (n)
  • 97.44 (a)
(Rattus norvegicus)
Mammalia Spz1 35
  • 65.17 (n)
  • 47.62 (a)
Species with no ortholog for SPZ1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPZ1 Gene

Gene Tree for SPZ1 (if available)
Gene Tree for SPZ1 (if available)

Paralogs for SPZ1 Gene

No data available for Paralogs for SPZ1 Gene

Variants for SPZ1 Gene

Sequence variations from dbSNP and Humsavar for SPZ1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1862136 - 80,320,264(+) AAACC(A/C/G)TTAAC reference, missense
rs6867419 - 80,321,119(+) AGCAT(A/G)AGCTG reference, missense
rs1052345 -- 80,321,809(+) TAAGT(A/T)AAGAT utr-variant-3-prime
rs1500138 -- 80,318,122(+) GAATA(C/T)AGTAT upstream-variant-2KB
rs1500139 -- 80,321,797(+) TAAAG(G/T)TCCAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SPZ1 Gene

Variant ID Type Subtype PubMed ID
nsv518480 CNV Gain 19592680

Variation tolerance for SPZ1 Gene

Residual Variation Intolerance Score: 94.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.46; 54.92% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SPZ1 Gene

Disorders for SPZ1 Gene

Relevant External Links for SPZ1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SPZ1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPZ1 Gene

Publications for SPZ1 Gene

  1. bHLH-zip transcription factor Spz1 mediates mitogen-activated protein kinase cell proliferation, transformation, and tumorigenesis. (PMID: 15899793) Hsu S.-H. … Li H. (Cancer Res. 2005) 2 3 4 67
  2. Patterns of expression of sperm flagellar genes: early expression of genes encoding axonemal proteins during the spermatogenic cycle and shared features of promoters of genes encoding central apparatus proteins. (PMID: 15829580) Horowitz E. … Strauss J.F. (Mol. Hum. Reprod. 2005) 2 3
  3. Identification of the spermatogenic zip protein Spz1 as a putative protein phosphatase-1 (PP1) regulatory protein that specifically binds the PP1cgamma2 splice variant in mouse testis. (PMID: 15226296) Hrabchak C. … Varmuza S. (J. Biol. Chem. 2004) 2 3
  4. Expression of a novel bHLH-Zip gene in human testis. (PMID: 12778315) Sha J.-H. … Zhou K.-Y. (Asian J. Androl. 2003) 2 3
  5. Spz1, a novel bHLH-Zip protein, is specifically expressed in testis. (PMID: 11165476) Hsu S.H. … Li H. (Mech. Dev. 2001) 2 3

Products for SPZ1 Gene

Sources for SPZ1 Gene