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Aliases for SPX Gene

Aliases for SPX Gene

  • Spexin Hormone 2 3 4 5
  • Neuropeptide Q 2 3 4
  • C12orf39 3 4
  • NPQ 3 4
  • Chromosome 12 Open Reading Frame 39 2
  • Spexin 3

External Ids for SPX Gene

Previous HGNC Symbols for SPX Gene

  • C12orf39

Summaries for SPX Gene

Entrez Gene Summary for SPX Gene

  • The protein encoded by this gene is a hormone involved in modulation of cardiovascular and renal function. It has also been shown in rats to cause weight loss. Several transcript variants have been found for this gene. [provided by RefSeq, Feb 2016]

GeneCards Summary for SPX Gene

SPX (Spexin Hormone) is a Protein Coding gene. GO annotations related to this gene include hormone activity and type 2 galanin receptor binding.

UniProtKB/Swiss-Prot for SPX Gene

  • Plays a role as a central modulator of cardiovascular and renal function and nociception. Plays also a role in energy metabolism and storage. Inhibits adrenocortical cell proliferation with minor stimulation on corticosteroid release (By similarity).

  • Spexin-1: Intracerebroventricular administration of the peptide induces an increase in arterial blood pressure, a decrease in both heart rate and renal excretion and delayed natriuresis. Intraventricular administration of the peptide induces antinociceptive activity. Also induces contraction of muscarinic-like stomach smooth muscles. Intraperitoneal administration of the peptide induces a reduction in food consumption and body weight. Inhibits long chain fatty acid uptake into adipocytes (By similarity). Acts as a ligand for galanin receptors GALR2 and GALR3 (PubMed:17284679, PubMed:24517231).

  • Spexin-2: Intracerebroventricular administration of the peptide induces a decrease in heart rate, but no change in arterial pressure, and an increase in urine flow rate. Intraventricular administration of the peptide induces antinociceptive activity (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPX Gene

Genomics for SPX Gene

Regulatory Elements for SPX Gene

Enhancers for SPX Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G021560 0.7 ENCODE 32.2 +34.1 34095 0.2 MAFG MAX NR3C1 RAD21 YY1 ZNF316 MAFF ATF3 HNF4A EMSY SPX GC12M021550 GC12P021565
GH12G021551 0.4 ENCODE 29.6 +26.4 26414 3.0 ZNF366 SPX GYS2 ENSG00000256615 LDHB GC12M021550
GH12G021559 0.4 ENCODE 29.1 +33.8 33755 0.2 CEBPB NR3C1 SPX GYS2 GC12M021550 GC12P021565
GH12G021527 0.9 ENCODE 12 +1.5 1518 1.5 ZSCAN4 SIN3A ZNF2 RAD21 YY1 ZNF121 GLIS2 ZNF654 ZNF362 CEBPB SPX PYROXD1 GYS2 GC12M021550
GH12G021642 0.8 ENCODE dbSUPER 10 +116.7 116739 0.9 MTA2 HLF CEBPB PRDM1 SPX LDHB GC12P021652 GYS2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPX on UCSC Golden Path with GeneCards custom track

Promoters for SPX Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000049634 1494 1199 ZSCAN4 SIN3A ZNF2 RAD21 YY1 ZNF121 ZNF654 ZNF362 CEBPB REST

Genomic Location for SPX Gene

Chromosome:
12
Start:
21,526,307 bp from pter
End:
21,537,377 bp from pter
Size:
11,071 bases
Orientation:
Plus strand

Genomic View for SPX Gene

Genes around SPX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPX Gene

Proteins for SPX Gene

  • Protein details for SPX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BT56-SPXN_HUMAN
    Recommended name:
    Spexin
    Protein Accession:
    Q9BT56
    Secondary Accessions:
    • B3KND6

    Protein attributes for SPX Gene

    Size:
    116 amino acids
    Molecular mass:
    13302 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPX Gene

Post-translational modifications for SPX Gene

No Post-translational modifications

Other Protein References for SPX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPX Gene

Domains & Families for SPX Gene

Protein Domains for SPX Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPX: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SPX Gene

Function for SPX Gene

Molecular function for SPX Gene

UniProtKB/Swiss-Prot Function:
Plays a role as a central modulator of cardiovascular and renal function and nociception. Plays also a role in energy metabolism and storage. Inhibits adrenocortical cell proliferation with minor stimulation on corticosteroid release (By similarity).
UniProtKB/Swiss-Prot Function:
Spexin-1: Intracerebroventricular administration of the peptide induces an increase in arterial blood pressure, a decrease in both heart rate and renal excretion and delayed natriuresis. Intraventricular administration of the peptide induces antinociceptive activity. Also induces contraction of muscarinic-like stomach smooth muscles. Intraperitoneal administration of the peptide induces a reduction in food consumption and body weight. Inhibits long chain fatty acid uptake into adipocytes (By similarity). Acts as a ligand for galanin receptors GALR2 and GALR3 (PubMed:17284679, PubMed:24517231).
UniProtKB/Swiss-Prot Function:
Spexin-2: Intracerebroventricular administration of the peptide induces a decrease in heart rate, but no change in arterial pressure, and an increase in urine flow rate. Intraventricular administration of the peptide induces antinociceptive activity (By similarity).
UniProtKB/Swiss-Prot Induction:
Down-regulated in omental and subcutaneous fat of obese subjects.

Gene Ontology (GO) - Molecular Function for SPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity IEA --
GO:0005184 neuropeptide hormone activity IEA --
genes like me logo Genes that share ontologies with SPX: view

Phenotypes for SPX Gene

GenomeRNAi human phenotypes for SPX:
genes like me logo Genes that share phenotypes with SPX: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPX Gene

Localization for SPX Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPX Gene

Secreted. Secreted, extracellular space. Cytoplasmic vesicle, secretory vesicle. Note=Secreted via the classical ER/Golgi-dependent pathway into the extracellular medium largely as a full-length protein without the signal peptide, and not as a hydrolyzed and amidated peptide (PubMed:19193193 and PubMed:17284679). Localized extracellularly surrounding the villous trophoblastic cells. Detected in the serum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPX gene
Compartment Confidence
extracellular 5
cytosol 1

Gene Ontology (GO) - Cellular Components for SPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA,IEA 19193193
GO:0030133 transport vesicle IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with SPX: view

Pathways & Interactions for SPX Gene

No Data Available

Interacting Proteins for SPX Gene

Selected Interacting proteins: Q9BT56-SPXN_HUMAN for SPX Gene via IID

Gene Ontology (GO) - Biological Process for SPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003084 positive regulation of systemic arterial blood pressure ISS --
GO:0010459 negative regulation of heart rate ISS --
GO:0032099 negative regulation of appetite ISS --
GO:0035814 negative regulation of renal sodium excretion ISS --
GO:0044539 long-chain fatty acid import ISS --
genes like me logo Genes that share ontologies with SPX: view

No data available for Pathways by source and SIGNOR curated interactions for SPX Gene

Drugs & Compounds for SPX Gene

No Compound Related Data Available

Transcripts for SPX Gene

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPX Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f
SP1: - - - -
SP2: - -
SP3: - -
SP4: - -
SP5: -
SP6:

Relevant External Links for SPX Gene

GeneLoc Exon Structure for
SPX
ECgene alternative splicing isoforms for
SPX

Expression for SPX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPX Gene

Protein differential expression in normal tissues from HIPED for SPX Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPX Gene



Protein tissue co-expression partners for SPX Gene

NURSA nuclear receptor signaling pathways regulating expression of SPX Gene:

SPX

mRNA Expression by UniProt/SwissProt for SPX Gene:

Q9BT56-SPXN_HUMAN
Tissue specificity: Expressed in the type I glomic cells within the carotid body (at protein level). Expressed predominantly in pancreas, testis, kidney, brain and placenta. Expressed in submucosal layer of esophagus and stomach fundus.

Evidence on tissue expression from TISSUES for SPX Gene

  • Heart(5)
  • Nervous system(2.3)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with SPX: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPX Gene

Orthologs for SPX Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C12H12orf39 34
  • 99.71 (n)
C12orf39 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C5H12orf39 34 35
  • 84.48 (n)
dog
(Canis familiaris)
Mammalia C27H12orf39 34
  • 84.2 (n)
C12ORF39 35
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC691138 34
  • 76.44 (n)
mouse
(Mus musculus)
Mammalia B230216G23Rik 34 35
  • 76.15 (n)
Spx 16
chicken
(Gallus gallus)
Aves C12orf39 35
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C12orf39 35
  • 49 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC101882535 34
  • 55 (n)
C4H12orf39 35
  • 49 (a)
OneToOne
Species where no ortholog for SPX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPX Gene

ENSEMBL:
Gene Tree for SPX (if available)
TreeFam:
Gene Tree for SPX (if available)

Paralogs for SPX Gene

No data available for Paralogs for SPX Gene

Variants for SPX Gene

Sequence variations from dbSNP and Humsavar for SPX Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000981497 -- 21,533,064(+) GGCTT(G/T)TGTTT downstream-variant-500B
rs1001067841 -- 21,529,725(+) GCAAA(A/G)TTAAG intron-variant
rs1001351967 -- 21,529,994(+) GAGAG(C/T)TAATT intron-variant
rs1001575007 -- 21,526,326(+) ACTGA(C/G)AAGAT upstream-variant-2KB, utr-variant-5-prime
rs1001582206 -- 21,533,408(+) TACAT(A/T)ATTTT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SPX Gene

Variant ID Type Subtype PubMed ID
nsv1054220 CNV gain 25217958
nsv528556 CNV gain 19592680
nsv557741 CNV gain 21841781
nsv557743 CNV gain 21841781

Variation tolerance for SPX Gene

Residual Variation Intolerance Score: 58.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPX Gene

Disorders for SPX Gene

Relevant External Links for SPX

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPX

No disorders were found for SPX Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPX Gene

Publications for SPX Gene

  1. Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet-induced obesity. (PMID: 24550067) Walewski J.L. … Berk P.D. (Obesity 2014) 2 3 4 64
  2. Peptides derived from the prohormone proNPQ/spexin are potent central modulators of cardiovascular and renal function and nociception. (PMID: 22038051) Toll L. … Kapusta D.R. (FASEB J. 2012) 2 3 4 64
  3. Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III. (PMID: 24517231) Kim D.K. … Seong J.Y. (Endocrinology 2014) 3 4 64
  4. C12ORF39, a novel secreted protein with a typical amidation processing signal. (PMID: 19193193) Wan B. … Han Z.G. (Biosci. Rep. 2010) 3 4 64
  5. Evolutionary sequence modeling for discovery of peptide hormones. (PMID: 19132080) Sonmez K. … Toll L. (PLoS Comput. Biol. 2009) 3 4 64

Products for SPX Gene

Sources for SPX Gene

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