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Aliases for SPX Gene

Aliases for SPX Gene

  • Spexin Hormone 2 3 4 5
  • Neuropeptide Q 2 3 4
  • C12orf39 3 4
  • NPQ 3 4
  • Chromosome 12 Open Reading Frame 39 2

External Ids for SPX Gene

Previous HGNC Symbols for SPX Gene

  • C12orf39

Summaries for SPX Gene

Entrez Gene Summary for SPX Gene

  • The protein encoded by this gene is a hormone involved in modulation of cardiovascular and renal function. It has also been shown in rats to cause weight loss. Several transcript variants have been found for this gene. [provided by RefSeq, Feb 2016]

GeneCards Summary for SPX Gene

SPX (Spexin Hormone) is a Protein Coding gene. Diseases associated with SPX include locked-in syndrome. GO annotations related to this gene include hormone activity and type 2 galanin receptor binding.

UniProtKB/Swiss-Prot for SPX Gene

  • Plays a role as a central modulator of cardiovascular and renal function and nociception. Plays also a role in energy metabolism and storage. Inhibits adrenocortical cell proliferation with minor stimulation on corticosteroid release (By similarity).

  • Spexin-1: Intracerebroventricular administration of the peptide induces an increase in arterial blood pressure, a decrease in both heart rate and renal excretion and delayed natriuresis. Intraventricular administration of the peptide induces antinociceptive activity. Also induces contraction of muscarinic-like stomach smooth muscles. Intraperitoneal administration of the peptide induces a reduction in food consumption and body weight. Inhibits long chain fatty acid uptake into adipocytes (By similarity). Acts as a ligand for galanin receptors GALR2 and GALR3 (PubMed:17284679, PubMed:24517231).

  • Spexin-2: Intracerebroventricular administration of the peptide induces a decrease in heart rate, but no change in arterial pressure, and an increase in urine flow rate. Intraventricular administration of the peptide induces antinociceptive activity (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPX Gene

Genomics for SPX Gene

Regulatory Elements for SPX Gene

Promoters for SPX Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SPX on UCSC Golden Path with GeneCards custom track

Genomic Location for SPX Gene

Chromosome:
12
Start:
21,526,307 bp from pter
End:
21,537,377 bp from pter
Size:
11,071 bases
Orientation:
Plus strand

Genomic View for SPX Gene

Genes around SPX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPX Gene

Proteins for SPX Gene

  • Protein details for SPX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BT56-SPXN_HUMAN
    Recommended name:
    Spexin
    Protein Accession:
    Q9BT56
    Secondary Accessions:
    • B3KND6

    Protein attributes for SPX Gene

    Size:
    116 amino acids
    Molecular mass:
    13302 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPX Gene

Proteomics data for SPX Gene at MOPED

Post-translational modifications for SPX Gene

No Post-translational modifications

Other Protein References for SPX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPX Gene

Domains & Families for SPX Gene

Protein Domains for SPX Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPX: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SPX Gene

Function for SPX Gene

Molecular function for SPX Gene

UniProtKB/Swiss-Prot Function:
Plays a role as a central modulator of cardiovascular and renal function and nociception. Plays also a role in energy metabolism and storage. Inhibits adrenocortical cell proliferation with minor stimulation on corticosteroid release (By similarity).
UniProtKB/Swiss-Prot Function:
Spexin-1: Intracerebroventricular administration of the peptide induces an increase in arterial blood pressure, a decrease in both heart rate and renal excretion and delayed natriuresis. Intraventricular administration of the peptide induces antinociceptive activity. Also induces contraction of muscarinic-like stomach smooth muscles. Intraperitoneal administration of the peptide induces a reduction in food consumption and body weight. Inhibits long chain fatty acid uptake into adipocytes (By similarity). Acts as a ligand for galanin receptors GALR2 and GALR3 (PubMed:17284679, PubMed:24517231).
UniProtKB/Swiss-Prot Function:
Spexin-2: Intracerebroventricular administration of the peptide induces a decrease in heart rate, but no change in arterial pressure, and an increase in urine flow rate. Intraventricular administration of the peptide induces antinociceptive activity (By similarity).
UniProtKB/Swiss-Prot Induction:
Down-regulated in omental and subcutaneous fat of obese subjects.

Phenotypes for SPX Gene

GenomeRNAi human phenotypes for SPX:
genes like me logo Genes that share phenotypes with SPX: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPX Gene

Localization for SPX Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPX Gene

Secreted. Secreted, extracellular space. Cytoplasmic vesicle, secretory vesicle. Note=Secreted via the classical ER/Golgi-dependent pathway into the extracellular medium largely as a full-length protein without the signal peptide, and not as a hydrolyzed and amidated peptide (PubMed:19193193 and PubMed:17284679). Localized extracellularly surrounding the villous trophoblastic cells. Detected in the serum.

Gene Ontology (GO) - Cellular Components for SPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030133 transport vesicle IEA --
genes like me logo Genes that share ontologies with SPX: view

No data available for Subcellular locations from COMPARTMENTS for SPX Gene

Pathways & Interactions for SPX Gene

SuperPathways for SPX Gene

No Data Available

Interacting Proteins for SPX Gene

Gene Ontology (GO) - Biological Process for SPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010459 negative regulation of heart rate ISS --
GO:0035814 negative regulation of renal sodium excretion ISS --
GO:0044539 long-chain fatty acid import IEA,ISS --
genes like me logo Genes that share ontologies with SPX: view

No data available for Pathways by source and SIGNOR curated interactions for SPX Gene

Drugs & Compounds for SPX Gene

No Compound Related Data Available

Transcripts for SPX Gene

Alternative Splicing Database (ASD) splice patterns (SP) for SPX Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f
SP1: - - - -
SP2: - -
SP3: - -
SP4: - -
SP5: -
SP6:

Relevant External Links for SPX Gene

GeneLoc Exon Structure for
SPX
ECgene alternative splicing isoforms for
SPX

Expression for SPX Gene

mRNA expression in normal human tissues for SPX Gene

Protein differential expression in normal tissues from HIPED for SPX Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPX Gene



mRNA Expression by UniProt/SwissProt for SPX Gene

Q9BT56-SPXN_HUMAN
Tissue specificity: Expressed in the type I glomic cells within the carotid body (at protein level). Expressed predominantly in pancreas, testis, kidney, brain and placenta. Expressed in submucosal layer of esophagus and stomach fundus.
genes like me logo Genes that share expression patterns with SPX: view

Protein tissue co-expression partners for SPX Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SPX Gene

Orthologs for SPX Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPX Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C5H12orf39 35
  • 84.48 (n)
  • 75.86 (a)
C5H12orf39 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C27H12orf39 35
  • 84.2 (n)
  • 81.9 (a)
C12ORF39 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia B230216G23Rik 35
  • 76.15 (n)
  • 67.24 (a)
Spx 16
B230216G23Rik 36
  • 65 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C12H12orf39 35
  • 99.71 (n)
  • 99.14 (a)
C12orf39 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC691138 35
  • 76.44 (n)
  • 66.38 (a)
chicken
(Gallus gallus)
Aves C12orf39 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C12orf39 36
  • 49 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC101882535 35
  • 55 (n)
  • 51 (a)
C4H12orf39 36
  • 49 (a)
OneToOne
Species with no ortholog for SPX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPX Gene

ENSEMBL:
Gene Tree for SPX (if available)
TreeFam:
Gene Tree for SPX (if available)

Paralogs for SPX Gene

No data available for Paralogs for SPX Gene

Variants for SPX Gene

Sequence variations from dbSNP and Humsavar for SPX Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2306178 -- 21,528,885(-) ACCCC(C/T)CAACA intron-variant
rs1993871 -- 21,529,863(-) CTGGG(C/T)TCCAT intron-variant
rs7132029 -- 21,529,166(+) CACCC(C/T)TCCCC intron-variant
rs7302146 -- 21,528,034(+) CGGCC(C/G)AGGCT intron-variant
rs7313823 -- 21,528,679(+) TTTGA(A/G)TTCTT intron-variant

Variation tolerance for SPX Gene

Residual Variation Intolerance Score: 58.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPX Gene

HapMap Linkage Disequilibrium report
SPX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SPX Gene

Disorders for SPX Gene

MalaCards: The human disease database

(1) MalaCards diseases for SPX Gene - From: DISEASES

Disorder Aliases PubMed IDs
locked-in syndrome
  • locked in syndrome
- elite association - COSMIC cancer census association via MalaCards
Search SPX in MalaCards View complete list of genes associated with diseases

Relevant External Links for SPX

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPX
genes like me logo Genes that share disorders with SPX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPX Gene

Publications for SPX Gene

  1. Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet-induced obesity. (PMID: 24550067) Walewski J.L. … Berk P.D. (Obesity 2014) 2 3 4 67
  2. Peptides derived from the prohormone proNPQ/spexin are potent central modulators of cardiovascular and renal function and nociception. (PMID: 22038051) Toll L. … Kapusta D.R. (FASEB J. 2012) 2 3
  3. Spexin peptide is expressed in human endocrine and epithelial tissues and reduced after glucose load in type 2 diabetes. (PMID: 26211893) Gu L. … Peng Y. (Peptides 2015) 3
  4. Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III. (PMID: 24517231) Kim D.K. … Seong J.Y. (Endocrinology 2014) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for SPX Gene

Sources for SPX Gene

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