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Aliases for SPX Gene

Aliases for SPX Gene

  • Spexin Hormone 2 3 4
  • Neuropeptide Q 2 3 4
  • C12orf39 3 4
  • NPQ 3 4
  • Chromosome 12 Open Reading Frame 39 2
  • Spexin 3
  • AG 6

External Ids for SPX Gene

Previous Symbols for SPX Gene

  • C12orf39

Summaries for SPX Gene

GeneCards Summary for SPX Gene

SPX (Spexin Hormone) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SPX Gene

  • Plays a role as a central modulator of cardiovascular and renal function and nociception. Plays also a role in energy metabolism and storage. Inhibits adrenocortical cell proliferation with minor stimulation on corticosteroid release (By similarity).

  • Spexin-1: Intracerebroventricular administration of the peptide induces an increase in arterial blood pressure, a decrease in both heart rate and renal excretion and delayed natriuresis. Intraventricular administration of the peptide induces antinociceptive activity. Also induces contraction of muscarinic-like stomach smooth muscles. Intraperitoneal administration of the peptide induces a reduction in food consumption and body weight. Inhibits long chain fatty acid uptake into adipocytes (By similarity). Acts as a ligand for galanin receptors GALR2 and GALR3 (PubMed:17284679, PubMed:24517231).

  • Spexin-2: Intracerebroventricular administration of the peptide induces a decrease in heart rate, but no change in arterial pressure, and an increase in urine flow rate. Intraventricular administration of the peptide induces antinociceptive activity (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPX Gene

Genomics for SPX Gene

Genomic Location for SPX Gene

Start:
21,526,307 bp from pter
End:
21,537,377 bp from pter
Size:
11,071 bases
Orientation:
Plus strand

Genomic View for SPX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPX Gene

No data available for Regulatory Elements for SPX Gene

Proteins for SPX Gene

  • Protein details for SPX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BT56-SPXN_HUMAN
    Recommended name:
    Spexin
    Protein Accession:
    Q9BT56
    Secondary Accessions:
    • B3KND6

    Protein attributes for SPX Gene

    Size:
    116 amino acids
    Molecular mass:
    13302 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPX Gene

Proteomics data for SPX Gene at MOPED

Post-translational modifications for SPX Gene

No Post-translational modifications

Other Protein References for SPX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPX Gene

Domains for SPX Gene

Protein Domains for SPX Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with SPX: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SPX Gene

Function for SPX Gene

Molecular function for SPX Gene

UniProtKB/Swiss-Prot Function: Plays a role as a central modulator of cardiovascular and renal function and nociception. Plays also a role in energy metabolism and storage. Inhibits adrenocortical cell proliferation with minor stimulation on corticosteroid release (By similarity).
UniProtKB/Swiss-Prot Function: Spexin-1: Intracerebroventricular administration of the peptide induces an increase in arterial blood pressure, a decrease in both heart rate and renal excretion and delayed natriuresis. Intraventricular administration of the peptide induces antinociceptive activity. Also induces contraction of muscarinic-like stomach smooth muscles. Intraperitoneal administration of the peptide induces a reduction in food consumption and body weight. Inhibits long chain fatty acid uptake into adipocytes (By similarity). Acts as a ligand for galanin receptors GALR2 and GALR3 (PubMed:17284679, PubMed:24517231).
UniProtKB/Swiss-Prot Function: Spexin-2: Intracerebroventricular administration of the peptide induces a decrease in heart rate, but no change in arterial pressure, and an increase in urine flow rate. Intraventricular administration of the peptide induces antinociceptive activity (By similarity).
UniProtKB/Swiss-Prot Induction: Down-regulated in omental and subcutaneous fat of obese subjects.

Gene Ontology (GO) - Molecular Function for SPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity --
GO:0005184 neuropeptide hormone activity IEA --
GO:0031765 type 2 galanin receptor binding IDA 24517231
GO:0031766 type 3 galanin receptor binding IDA 24517231
genes like me logo Genes that share ontologies with SPX: view

Phenotypes for SPX Gene

GenomeRNAi human phenotypes for SPX:
genes like me logo Genes that share phenotypes with SPX: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SPX Gene

Localization for SPX Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPX Gene

Secreted. Secreted, extracellular space. Cytoplasmic vesicle, secretory vesicle. Note=Secreted via the classical ER/Golgi-dependent pathway into the extracellular medium largely as a full-length protein without the signal peptide, and not as a hydrolyzed and amidated peptide (PubMed:19193193 and PubMed:17284679). Localized extracellularly surrounding the villous trophoblastic cells. Detected in the serum.

Gene Ontology (GO) - Cellular Components for SPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 19193193
GO:0030133 transport vesicle IEA --
GO:0031410 cytoplasmic vesicle --
genes like me logo Genes that share ontologies with SPX: view

Pathways for SPX Gene

SuperPathways for SPX Gene

No Data Available

Interacting Proteins for SPX Gene

Gene Ontology (GO) - Biological Process for SPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003084 positive regulation of systemic arterial blood pressure ISS --
GO:0010459 negative regulation of heart rate ISS --
GO:0032099 negative regulation of appetite ISS --
GO:0035814 negative regulation of renal sodium excretion ISS --
GO:0044539 long-chain fatty acid import ISS --
genes like me logo Genes that share ontologies with SPX: view

No data available for Pathways by source for SPX Gene

Transcripts for SPX Gene

Alternative Splicing Database (ASD) splice patterns (SP) for SPX Gene

No ASD Table

Relevant External Links for SPX Gene

GeneLoc Exon Structure for
SPX
ECgene alternative splicing isoforms for
SPX

Expression for SPX Gene

mRNA expression in normal human tissues for SPX Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SPX Gene

mRNA Expression by UniProt/SwissProt for SPX Gene

Q9BT56-SPXN_HUMAN
Tissue specificity: Expressed in the type I glomic cells within the carotid body (at protein level). Expressed predominantly in pancreas, testis, kidney, brain and placenta. Expressed in submucosal layer of esophagus and stomach fundus.
genes like me logo Genes that share expressions with SPX: view

Orthologs for SPX Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C12H12orf39 36
  • 99.71 (n)
  • 99.14 (a)
C12orf39 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C5H12orf39 36
  • 84.48 (n)
  • 75.86 (a)
C5H12orf39 37
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C12ORF39 37
  • 82 (a)
OneToOne
C27H12orf39 36
  • 84.2 (n)
  • 81.9 (a)
mouse
(Mus musculus)
Mammalia B230216G23Rik 36
  • 76.15 (n)
  • 67.24 (a)
B230216G23Rik 37
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC691138 36
  • 76.44 (n)
  • 66.38 (a)
chicken
(Gallus gallus)
Aves C12orf39 37
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C12orf39 37
  • 49 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C4H12orf39 37
  • 49 (a)
OneToOne
LOC101882535 36
  • 55 (n)
  • 51 (a)
Species with no ortholog for SPX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPX Gene

ENSEMBL:
Gene Tree for SPX (if available)
TreeFam:
Gene Tree for SPX (if available)

Paralogs for SPX Gene

No data available for Paralogs for SPX Gene

Variants for SPX Gene

Sequence variations from dbSNP and Humsavar for SPX Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1993871 -- 21,529,863(-) CTGGG(C/T)TCCAT intron-variant
rs2306178 -- 21,528,885(-) ACCCC(C/T)CAACA intron-variant
rs7132029 -- 21,529,166(+) CACCC(C/T)TCCCC intron-variant
rs7137087 -- 21,530,633(+) GTTTC(A/G)CGATC intron-variant
rs7138234 -- 21,525,783(+) ACCTA(C/T)GATTA upstream-variant-2KB

Relevant External Links for SPX Gene

HapMap Linkage Disequilibrium report
SPX

No data available for Structural Variations from Database of Genomic Variants (DGV) for SPX Gene

Disorders for SPX Gene

No disorders were found for SPX Gene.

No data available for UniProtKB/Swiss-Prot for SPX Gene

Publications for SPX Gene

  1. Peptides derived from the prohormone proNPQ/spexin are potent central modulators of cardiovascular and renal function and nociception. (PMID: 22038051) Toll L. … Kapusta D.R. (FASEB J. 2012) 2 3 4
  2. Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet-induced obesity. (PMID: 24550067) Walewski J.L. … Berk P.D. (Obesity 2014) 2 3 4
  3. Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III. (PMID: 24517231) Kim D.K. … Seong J.Y. (Endocrinology 2014) 3 4
  4. Evolutionary sequence modeling for discovery of peptide hormones. (PMID: 19132080) Sonmez K. … Toll L. (PLoS Comput. Biol. 2009) 3 4
  5. C12ORF39, a novel secreted protein with a typical amidation processing signal. (PMID: 19193193) Wan B. … Han Z.G. (Biosci. Rep. 2010) 3 4

Products for SPX Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate SPX
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for SPX
    • Block miRNA regulation of SPX using miScript Target Protectors

    Sources for SPX Gene

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