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Aliases for SPTY2D1 Gene

Aliases for SPTY2D1 Gene

  • SPT2 Chromatin Protein Domain Containing 1 2 3
  • SPT2, Suppressor Of Ty, Domain Containing 1 (S. Cerevisiae) 2
  • SPT2 Domain-Containing Protein 1 4
  • Protein KU002155 4

External Ids for SPTY2D1 Gene

Previous GeneCards Identifiers for SPTY2D1 Gene

  • GC11M018585
  • GC11M018312

Summaries for SPTY2D1 Gene

GeneCards Summary for SPTY2D1 Gene

SPTY2D1 (SPT2 Chromatin Protein Domain Containing 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPTY2D1 Gene

Genomics for SPTY2D1 Gene

Regulatory Elements for SPTY2D1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SPTY2D1 Gene

18,606,401 bp from pter
18,634,791 bp from pter
28,391 bases
Minus strand

Genomic View for SPTY2D1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPTY2D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPTY2D1 Gene

Proteins for SPTY2D1 Gene

  • Protein details for SPTY2D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein SPT2 homolog
    Protein Accession:
    Secondary Accessions:
    • Q6AWA5
    • Q6MZI5
    • Q7Z390
    • Q7Z470
    • Q86VG8
    • Q8N3E7
    • Q8N417
    • Q8N8I3

    Protein attributes for SPTY2D1 Gene

    685 amino acids
    Molecular mass:
    75599 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAP13351.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SPTY2D1 Gene

    Alternative splice isoforms for SPTY2D1 Gene


neXtProt entry for SPTY2D1 Gene

Proteomics data for SPTY2D1 Gene at MOPED

Post-translational modifications for SPTY2D1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPTY2D1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPTY2D1 Gene

Domains & Families for SPTY2D1 Gene

Protein Domains for SPTY2D1 Gene


Suggested Antigen Peptide Sequences for SPTY2D1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SPT2 family.
  • Belongs to the SPT2 family.
genes like me logo Genes that share domains with SPTY2D1: view

No data available for Gene Families for SPTY2D1 Gene

Function for SPTY2D1 Gene

Gene Ontology (GO) - Molecular Function for SPTY2D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001042 RNA polymerase I core binding ISS --
GO:0003674 molecular_function ND --
GO:0003677 DNA binding IDA 23378026
GO:0042393 histone binding IDA 23378026
genes like me logo Genes that share ontologies with SPTY2D1: view

Phenotypes for SPTY2D1 Gene

GenomeRNAi human phenotypes for SPTY2D1:
genes like me logo Genes that share phenotypes with SPTY2D1: view

Animal Model Products

CRISPR Products

miRNA for SPTY2D1 Gene

miRTarBase miRNAs that target SPTY2D1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPTY2D1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SPTY2D1 Gene

Localization for SPTY2D1 Gene

Subcellular locations from

Jensen Localization Image for SPTY2D1 Gene COMPARTMENTS Subcellular localization image for SPTY2D1 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SPTY2D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005730 nucleolus ISS --
genes like me logo Genes that share ontologies with SPTY2D1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SPTY2D1 Gene

Pathways & Interactions for SPTY2D1 Gene

SuperPathways for SPTY2D1 Gene

No Data Available

Interacting Proteins for SPTY2D1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: Q68D10-SPT2_HUMAN ENSP00000337991 for SPTY2D1 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for SPTY2D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IMP 23378026
GO:0006355 regulation of transcription, DNA-templated IMP 26109053
GO:0008150 biological_process ND --
GO:0010847 regulation of chromatin assembly IMP 26109053
GO:0043486 histone exchange IMP 26109053
genes like me logo Genes that share ontologies with SPTY2D1: view

No data available for Pathways by source and SIGNOR curated interactions for SPTY2D1 Gene

Drugs & Compounds for SPTY2D1 Gene

No Compound Related Data Available

Transcripts for SPTY2D1 Gene

mRNA/cDNA for SPTY2D1 Gene

Unigene Clusters for SPTY2D1 Gene

SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPTY2D1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPTY2D1 Gene

No ASD Table

Relevant External Links for SPTY2D1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPTY2D1 Gene

mRNA expression in normal human tissues for SPTY2D1 Gene

Protein differential expression in normal tissues from HIPED for SPTY2D1 Gene

This gene is overexpressed in Heart (28.3), CD8 Tcells (25.6), and Fetal Liver (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPTY2D1 Gene

SOURCE GeneReport for Unigene cluster for SPTY2D1 Gene Hs.745113

genes like me logo Genes that share expression patterns with SPTY2D1: view

Protein tissue co-expression partners for SPTY2D1 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SPTY2D1 Gene

Orthologs for SPTY2D1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPTY2D1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SPTY2D1 35
  • 87.42 (n)
  • 84.09 (a)
SPTY2D1 36
  • 84 (a)
(Canis familiaris)
Mammalia SPTY2D1 35
  • 89.38 (n)
  • 86.28 (a)
SPTY2D1 36
  • 83 (a)
(Mus musculus)
Mammalia Spty2d1 35
  • 84.39 (n)
  • 80.61 (a)
Spty2d1 16
Spty2d1 36
  • 80 (a)
(Pan troglodytes)
Mammalia SPTY2D1 35
  • 99.15 (n)
  • 98.94 (a)
SPTY2D1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia LOC100365259 35
  • 84.27 (n)
  • 82.25 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 62 (a)
-- 36
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia SPTY2D1 36
  • 55 (a)
(Gallus gallus)
Aves SPTY2D1 35
  • 61.31 (n)
  • 58.66 (a)
SPTY2D1 36
  • 54 (a)
(Anolis carolinensis)
Reptilia SPTY2D1 36
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10782 35
(Danio rerio)
Actinopterygii wufb01d08 35
spty2d1 36
  • 43 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5815 36
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7207 36
  • 35 (a)
Species with no ortholog for SPTY2D1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPTY2D1 Gene

Gene Tree for SPTY2D1 (if available)
Gene Tree for SPTY2D1 (if available)

Paralogs for SPTY2D1 Gene

No data available for Paralogs for SPTY2D1 Gene

Variants for SPTY2D1 Gene

Sequence variations from dbSNP and Humsavar for SPTY2D1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs190218518 -- 18,611,199(+) GCACT(A/T)TGGGA intron-variant
rs190013915 -- 18,632,585(+) TTCAG(G/T)TGATT intron-variant
rs189975853 -- 18,626,702(+) GTTAT(G/T)ATGAT intron-variant
rs189970025 -- 18,629,558(+) TCTAG(C/T)ATTCT intron-variant
rs189443086 -- 18,622,456(+) CAGGA(A/G)GTGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPTY2D1 Gene

Variant ID Type Subtype PubMed ID
nsv516413 CNV Loss 19592680

Variation tolerance for SPTY2D1 Gene

Residual Variation Intolerance Score: 54.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.44; 77.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPTY2D1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPTY2D1 Gene

Disorders for SPTY2D1 Gene

Relevant External Links for SPTY2D1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SPTY2D1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPTY2D1 Gene

Publications for SPTY2D1 Gene

  1. Vertebrate Spt2 is a novel nucleolar histone chaperone that assists in ribosomal DNA transcription. (PMID: 23378026) Osakabe A. … Kurumizaka H. (J. Cell. Sci. 2013) 2 67
  2. Structure-function studies of histone H3/H4 tetramer maintenance during transcription by chaperone Spt2. (PMID: 26109053) Chen S. … Patel D.J. (Genes Dev. 2015) 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. Discovery and refinement of loci associated with lipid levels. (PMID: 24097068) . … Abecasis G.R. (Nat. Genet. 2013) 67
  5. Genetic variants and environmental factors associated with hormonal markers of ovarian reserve in Caucasian and African American women. (PMID: 22116950) Schuh-Huerta S.M. … Reijo Pera R.A. (Hum. Reprod. 2012) 67

Products for SPTY2D1 Gene

Sources for SPTY2D1 Gene

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