SPTY2D1 Gene
protein-coding GIFtS: 41
GCID: GC11M018627
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SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae)
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Aliases for SPTY2D1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| SPT2, Suppressor Of Ty, Domain Containing 1 (S. Cerevisiae)1 2 | | SPT2 Domain-Containing Protein 12 3 | | DKFZp686I0681 | | FLJ394411 | | Protein SPT2 Homolog2 | | Protein KU0021553 |
Export aliases for SPTY2D1 gene to outside databasesPrevious GC identifers: GC11M018585 GC11M018312 |
Summaries for SPTY2D1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| -- |
Genomic Views for SPTY2D1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SPTY2D1 gene promoter: STAT5B C/EBPbeta STAT5A C/EBPalpha CHOP-10 STAT3 ARP-1 Hlf Other transcription factors
Search SABiosciences Chromatin IP Primers for SPTY2D1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPTY2D1 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p15.1 Ensembl cytogenetic band: 11p15.1 HGNC cytogenetic band: 11p15.1SPTY2D1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M018627: view genomic region
(about GC identifiers)
Start:
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18,627,948 bp from pter |
End:
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18,656,338 bp from pter |
Size:
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28,391 bases |
Orientation:
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minus strand |
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Proteins for SPTY2D1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: SPT2_HUMAN, Q68D10 (See
protein sequence)Recommended Name: Protein SPT2 homolog Size: 685 amino acids; 75599 Da
Sequence caution: Sequence=AAP13351.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q6AWA5 Q6MZI5 Q7Z390 Q7Z470 Q86VG8 Q8N3E7 Q8N417 Q8N8I3Alternative splicing: 3 isoforms: Q68D10-1 Q68D10-2 Q68D10-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SPTY2D1: NX_Q68D10
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q68D10 SPTY2D1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_919261.2 ENSEMBL proteins: ENSP00000337991 Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005575 | cellular_component |
ND | -- |
SPTY2D1 for ontologies About GeneDecksing
SPTY2D1 Antibody Products: Assay Products for SPTY2D1: |
Protein
Domains / Families for SPTY2D1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SPTY2D1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q68D10ProtoNet protein and cluster: Q68D10 UniProtKB/Swiss-Prot: SPT2_HUMAN, Q68D10Similarity: Belongs to the SPT2 family |
Function for SPTY2D1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPTY2D1 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPTY2D1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SPTY2D1 (NM_194285) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPTY2D1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPTY2D1  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPTY2D1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
SPTY2D1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SPTY2D1:
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Pathways & Interactions for SPTY2D1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPTY2D1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
 1 Interacting protein for SPTY2D1 (Q68D103 ENSP000003379914) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
SPTY2D1 for ontologies About GeneDecksing
|
Drugs & Compounds for SPTY2D1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for SPTY2D1 Search CenterWatch for drugs/clinical trials and news about SPTY2D1 / SPT2 
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Transcripts for SPTY2D1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for SPTY2D1 gene: NM_194285.2 Unigene Cluster for SPTY2D1: SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) Hs.268668 [show with all ESTs]Unigene Representative Sequence: NM_1942853 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000336349(uc001moy.3) ENST00000536336(uc010rdi.1) ENST00000543776
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPTY2D1 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPTY2D1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SPTY2D1 (NM_194285) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPTY2D1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPTY2D1  |
Additional cDNA sequence: AF086471.1 AF452716.1 AK096694.1 AK096760.1 AK304078.1 AL834393.1 BC036844.1 BC056261.1 BX538046.1 BX641102.1 BX647798.1 BX648478.1 CR749626.1 7 DOTS entries: DT.110761 DT.100025614 DT.101983783 DT.91734224 DT.40305625 DT.95254484 DT.100746204 24/93 AceView cDNA sequences (see all 93): BQ053472 BM887810 AA687968 BM747442 AI458826 AA831121 BI089573 CA425842 BM828726 BU177333 BX100112 BG393067 BM739037 BU902510 BM754985 AA768629 AK096694 AW207599 AF452716 AA227245 BC036844 BQ421790 BX096240 BU188093 GeneLoc Exon Structure
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Expression for SPTY2D1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPTY2D1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TTTGGAAAGA
About this image See SPTY2D1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SPTY2D1
SOURCE GeneReport for Unigene cluster: Hs.268668 SABiosciences Custom PCR Arrays for SPTY2D1
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPTY2D1 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SPTY2D1 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPTY2D1 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPTY2D1 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPTY2D1 |
Orthologs for SPTY2D1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of eukaryotes.
Orthologs for SPTY2D1 gene from 8/23 species (see all 23) About this table
ENSEMBL Gene Tree for SPTY2D1 (if available) TreeFam Gene Tree for SPTY2D1 (if available)  |
Paralogs for SPTY2D1 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
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Genomic Variants for SPTY2D1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 11 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for SPTY2D1 (18627948 - 18656338 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for SPTY2D1 1 CNV: 48762  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPTY2D1 |
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Disorders
/ Diseases for SPTY2D1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications for SPTY2D1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPTY2D1 gene, integrated from 9 sources (see all 12): (articles sorted by number of sources associating them with SPTY2D1) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Biological, clinical and population relevance of 95 l oci for blood lipids. (PubMed id 20686565)1 Teslovich T.M....Kathiresan S. (2010)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
- Large-scale analysis of the human ubiquitin-related p roteome. (PubMed id 16196087)1 Matsumoto M....Nakayama K.I. (2005)
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External Searches for SPTY2D1 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
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Genome Databases showing SPTY2D1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SPTY2D1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPTY2D1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for SPTY2D1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for SPTY2D1 gene: Search GeneIP for patents involving SPTY2D1
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products for SPTY2D1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for SPTY2D1 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPTY2D1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPTY2D1 | | OriGene Protein Over-expression Lysate for SPTY2D1 | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for SPTY2D1 | | OriGene 3'-UTR Clone for SPTY2D1 | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPTY2D1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPTY2D1 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for SPTY2D1 | | OriGene Custom Protein Services for SPTY2D1 | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPTY2D1 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPTY2D1 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPTY2D1 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPTY2D1 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPTY2D1 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPTY2D1 |
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| | | Search Tocris compounds for SPTY2D1 |
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 | | SPTY2D1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPTY2D1 |
|  |  |  | | | Search ThermoFisher Antibodies for SPTY2D1 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPTY2D1 |
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