Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SPTSSB Gene

protein-coding   GIFtS: 36
GCID: GC03M161063

Serine Palmitoyltransferase, Small Subunit B

(Previous name: chromosome 3 open reading frame 57)
(Previous symbol: C3orf57)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Serine Palmitoyltransferase, Small Subunit B1 2     Chromosome 3 Open Reading Frame 571
C3orf571 2 3 5     Likely Ortholog Of Androgen Down Regulated Gene Expressed In Mouse
Prostate2
Small Subunit Of Serine Palmitoyltransferase B1 2 3     Serine Palmitoyltransferase Small Subunit B2
ADMP2 3 5     Protein ADMP3
SSSPTB2 3 5     ssSPTb3
Androgen Down Regulated In Mouse Prostate1 2     

External Ids:    HGNC: 240451   Entrez Gene: 1656792   Ensembl: ENSG000001965427   OMIM: 6104125   UniProtKB: Q8NFR33   

Export aliases for SPTSSB gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SPTSSB Gene:
Serine palmitoyltransferase (SPT; EC 2.3.1.50) catalyzes the first committed and rate-limiting step in
sphingolipid biosynthesis. SSSPTB is a small SPT subunit that stimulates SPT activity and confers acyl-CoA
preference to the SPT catalytic heterodimer of SPTLC1 (MIM 605712) and either SPTLC2 (MIM 605713) or SPTLC3 (MIM
611120) (Han et al., 2009 (PubMed 19416851)).(supplied by OMIM, Nov 2010)

GeneCards Summary for SPTSSB Gene:
SPTSSB (serine palmitoyltransferase, small subunit B) is a protein-coding gene. Diseases associated with SPTSSB include prostatitis, and endotheliitis. GO annotations related to this gene include serine C-palmitoyltransferase activity. An important paralog of this gene is SPTSSA.

UniProtKB/Swiss-Prot: SPTSB_HUMAN, Q8NFR3
Function: Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine
palmitoyltransferase (SPT) complex determines the substrate preference, complexes with this subunit showing a
clear preference for longer acyl-CoAs. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA
substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs,
without apparent preference. May play a role in signal transduction




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_005612.17  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SPTSSB
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SPTSSB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPTSSB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.1   Ensembl cytogenetic band:  3q26.1   HGNC cytogenetic band: 3q26.1

SPTSSB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPTSSB gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M161063:  view genomic region     (about GC identifiers)

Start:
161,062,580 bp from pter      End:
161,090,668 bp from pter
Size:
28,089 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SPTSB_HUMAN, Q8NFR3 (See protein sequence)
Recommended Name: Serine palmitoyltransferase small subunit B  
Size: 76 amino acids; 9198 Da
Subunit: Interacts with SPTLC1; the interaction is direct. Component of the serine palmitoyltransferase (SPT)
complex, composed of SPTLC1, either SPTLC2 or SPTLC3, and either SPTSSA or SPTSSB
Secondary accessions: B2R5D3 D3DNM8 Q0P5S6

Explore the universe of human proteins at neXtProt for SPTSSB: NX_Q8NFR3

Explore proteomics data for SPTSSB at MOPED


See SPTSSB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001035189.1  
ENSEMBL proteins: 
 ENSP00000352097   ENSP00000420115  

SPTSSB Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for SPTSSB
OriGene Protein Over-expression Lysate for SPTSSB
OriGene MassSpec for SPTSSB
OriGene Custom Protein Services for SPTSSB
GenScript Custom Purified and Recombinant Proteins Services for SPTSSB
Novus Biologicals SPTSSB Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp.

SPTSSB Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
OriGene Custom Antibody Services for SPTSSB
Search for Antibodies for SPTSSB at Abcam
Browse Antibodies at Cloud-Clone Corp.
Search ThermoFisher Antibodies for SPTSSB
Search LSBio for Antibodies for SPTSSB

SPTSSB Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for SPTSSB
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for SPTSSB
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp.
Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
1 InterPro protein domain:
 IPR024512 Ser_palmitoyltrfase_ssu-like

Graphical View of Domain Structure for InterPro Entry Q8NFR3

ProtoNet protein and cluster: Q8NFR3

UniProtKB/Swiss-Prot: SPTSB_HUMAN, Q8NFR3
Similarity: Belongs to the SPTSS family. SPTSSB subfamily


SPTSSB for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: SPTSB_HUMAN, Q8NFR3
Function: Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine
palmitoyltransferase (SPT) complex determines the substrate preference, complexes with this subunit showing a
clear preference for longer acyl-CoAs. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA
substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs,
without apparent preference. May play a role in signal transduction
Induction: Expression is suppressed by androgens in the androgen-sensitive LNCaP cell line

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004758contributes to serine C-palmitoyltransferase activity IDA19416851
GO:0005515protein binding IPI19416851
     
SPTSSB for ontologies           About GeneDecksing


Phenotypes:
     1 MGI phenotypic allele for Sptssb (no phenotypes)

SPTSSB for phenotypes           About GeneDecksing

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPTSSB
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SPTSSB

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPTSSB
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPTSSB

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat SPTSSB using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate SPTSSB
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for SPTSSB
Predesigned siRNA for gene silencing in human, mouse, rat SPTSSB

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for SPTSSB

Clone
Products:
     
OriGene clones in human, mouse for SPTSSB (see all 7)
OriGene ORF clones in mouse, rat for SPTSSB
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript Custom all cDNA clones Services for SPTSSB
Sino Biological Human cDNA Clone for SPTSSB
DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPTSSB
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPTSSB

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for SPTSSB
Browse ESI BIO Cell Lines and PureStem Progenitors for SPTSSB 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPTSSB


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
SPTSB_HUMAN, Q8NFR3: Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential)

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral component of membrane IEA--
GO:0017059serine C-palmitoyltransferase complex IDA19416851

SPTSSB for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus




UniProtKB/Swiss-Prot: SPTSB_HUMAN, Q8NFR3
Pathway: Lipid metabolism; sphingolipid metabolism

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPTSSB
Interactions:

    Search GeneGlobe Interaction Network for SPTSSB

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5 Interacting proteins for SPTSSB (ENSP000003520974) via UniProtKB, MINT, STRING, and/or I2D

InteractantInteraction Details
GeneCardExternal ID(s)
SPTLC1ENSP000002625544STRING: ENSP00000262554
SPTLC2ENSP000002164844STRING: ENSP00000216484
SPTLC3ENSP000003819684STRING: ENSP00000381968
SPTSSAENSP000002981304STRING: ENSP00000298130
ORMDL3ENSP000003048584STRING: ENSP00000304858
About this table

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0030148sphingolipid biosynthetic process TAS19416851

SPTSSB for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for SPTSSB (SPTSB)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for SPTSSB gene (2 alternative transcripts): 
NM_145035.2  NM_001040100.1  

Unigene Cluster for SPTSSB:

Serine palmitoyltransferase, small subunit B
Hs.369104  [show with all ESTs]
Unigene Representative Sequence: AK123348
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000359175(uc003fee.3) ENST00000497137 ENST00000497374
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat SPTSSB using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate SPTSSB
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for SPTSSB
Predesigned siRNA for gene silencing in human, mouse, rat SPTSSB
Clone
Products:
     
OriGene clones in human, mouse for SPTSSB (see all 7)
OriGene ORF clones in mouse, rat for SPTSSB
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript Custom all cDNA clones Services for SPTSSB
DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPTSSB
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPTSSB
Primer
Products:
    
OriGene qPCR primer pairs and template standards for SPTSSB
OriGene qSTAR qPCR primer pairs in human, mouse for SPTSSB
Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat SPTSSB
  QuantiTect SYBR Green Assays in human, mouse, rat SPTSSB
  QuantiFast Probe-based Assays in human, mouse, rat SPTSSB

Additional mRNA sequence: 

AF458592.1 AK123348.1 AK312144.1 BC037817.2 BC065208.1 BC071875.1 BC107756.1 BC126236.1 
BC130565.1 

1 DOTS entry:

DT.100645029 

Selected AceView cDNA sequences (see all 46):

AI921685 AK123348 NM_145035 CA487194 BU539808 AF458592 BG286222 BU934142 
BG289890 BC071875 BG402906 BQ778346 BI766630 BX509773 BV188397 BQ778568 
CA487941 BF365359 AI559486 BG403886 BG287503 CA455115 BU959155 BU950276 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

SPTSSB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
SPTSSB Expression
About this image


SPTSSB expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Epithelial Cells
         Fetal Matrix Cells Hair Follicle
 
 Hair (Integumentary System)
         Fetal Matrix Cells Hair Follicle
SPTSSB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SPTSSB Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.369104

UniProtKB/Swiss-Prot: SPTSB_HUMAN, Q8NFR3
Tissue specificity: Expression is seen predominantly in the prostate epithelium with weaker expression in the
fibroblasts and endothelial cells

    Custom PCR Arrays for SPTSSB
Primer
Products:
OriGene qPCR primer pairs and template standards for SPTSSB
OriGene qSTAR qPCR primer pairs in human, mouse for SPTSSB
Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat SPTSSB
QuantiTect SYBR Green Assays in human, mouse, rat SPTSSB
QuantiFast Probe-based Assays in human, mouse, rat SPTSSB
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPTSSB

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of chordates.

Orthologs for SPTSSB gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Sptssb1 , 5 RIKEN cDNA 1110032A04 gene5
serine palmitoyltransferase, small subunit B1
85.53(n)1
85.53(a)1
  3 (32.30 cM)5
661831  NM_001164210.21  NP_001157682.11 
 698195385 
chicken
(Gallus gallus)
Aves SPTSSB1 serine palmitoyltransferase, small subunit B 71.11(n)
66.67(a)
  425008  XM_003641780.2  XP_003641828.1 
lizard
(Anolis carolinensis)
Reptilia SPTSSB6
serine palmitoyltransferase, small subunit B
59(a)
1 ↔ 1
3(12570125-12570364)
tropical clawed frog
(Xenopus tropicalis)
Amphibia sptssb1 serine palmitoyltransferase, small subunit B 67.11(n)
65.33(a)
  549969  NM_001017215.2  NP_001017215.1 
zebrafish
(Danio rerio)
Actinopterygii sptssb1 serine palmitoyltransferase, small subunit B 63.29(n)
60.87(a)
  678546  NM_001159833.1  NP_001153305.1 


ENSEMBL Gene Tree for SPTSSB (if available)
TreeFam Gene Tree for SPTSSB (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for SPTSSB gene
SPTSSA2  
1 SIMAP similar gene for SPTSSB using alignment to 1 protein entry:     SPTSB_HUMAN:
SPTSSA

SPTSSB for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for SPTSSB (see all 594)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 3 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1444184101,2
C--161062271(+) GCCCGA/GTGTGG 1 -- ds50010--------
rs76524471,2
C,F,H--161062331(+) CTAATC/TGACCT 1 -- ds500117Minor allele frequency- T:0.18EA NS NA WA CSA 1995
rs1857811241,2
--161062347(+) AAGAAA/CTGTAA 1 -- ds50010--------
rs801132361,2
C,F--161062426(+) TGTCCA/CGCATG 1 -- ds50011Minor allele frequency- C:0.03WA 118
rs76301921,2
C,F--161062429(+) CCAGCA/CTGGAG 1 -- ds50012Minor allele frequency- C:0.06CSA WA 120
rs1413139181,2
C--161062467(+) GTTACC/TGTTTT 1 -- ds50010--------
rs76106781,2
C,F,A,H--161062468(+) TTACCG/ATTTTA 1 -- ds50015Minor allele frequency- A:0.04EA NS CSA WA 418
rs130593401,2
C,F,H--161062631(+) ATACAT/CGTTCA 1 -- ut3115Minor allele frequency- C:0.36NA EA NS WA CSA 810
rs1633271,2
C,F,H--161062724(-) CAAGGC/TGAGCT 1 -- ut3129Minor allele frequency- T:0.27MN NA EA NS WA CSA 2868
rs76108871,2
C,F,H--161062757(+) AACAAG/AGGTGC 1 -- ut3110Minor allele frequency- A:0.08EA NS NA CSA WA 1094

HapMap Linkage Disequilibrium report for SPTSSB (161062580 - 161090668 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for SPTSSB:    About this table    
Variant IDTypeSubtypePubMed ID
esv2726119CNV Deletion23290073
nsv4091CNV Loss18451855
nsv829770CNV Gain17160897
nsv877710CNV Gain21882294
nsv829772CNV Gain+Loss17160897

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing SPTSSB
DNA2.0 Custom Variant and Variant Library Synthesis for SPTSSB

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 610412    OMIM disorders: --

2 diseases for SPTSSB:    
About MalaCards
prostatitis    endotheliitis


SPTSSB for disorders           About GeneDecksing


Export disorders for SPTSSB gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for SPTSSB gene integrated from 10 sources:
(articles sorted by number of sources associating them with SPTSSB)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities. (PubMed id 19416851)1, 2, 3 Han G.... Dunn T.M. (Proc. Natl. Acad. Sci. U.S.A. 2009)
  2. Molecular cloning and characterization of a novel androgen repressible gene expressed in the prostate epithelium. (PubMed id 15777716)1, 2, 3 Singh J.... Dong Q. (Gene 2005)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  6. (PubMed id )2 

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 165679 HGNC: 24045 AceView: ADMP Ensembl:ENSG00000196542 euGenes: HUgn165679
ECgene: SPTSSB H-InvDB: SPTSSB

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for SPTSSB Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for SPTSSB gene:
Search GeneIP for patents involving SPTSSB

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SPTSSB  
 OriGene qPCR primer pairs and template standards for SPTSSB   OriGene Protein Over-expression Lysate for SPTSSB  
 OriGene MassSpec something-or-other for SPTSSB   OriGene clones in human, mouse for SPTSSB  
 OriGene qSTAR qPCR primer pairs in human, mouse for SPTSSB   OriGene Purified Protein for SPTSSB  
 OriGene ORF clones in mouse, rat for SPTSSB   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for SPTSSB   OriGene Custom Protein Services for SPTSSB  

 
 
 Block miRNA regulation of human, mouse, rat SPTSSB using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SPTSSB
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPTSSB Predesigned siRNA for gene silencing in human, mouse, rat SPTSSB
 QuantiFast Probe-based Assays in human, mouse, rat SPTSSB QuantiTect SYBR Green Assays in human, mouse, rat SPTSSB
 Custom PCR Arrays for SPTSSB Search Chromatin IP Primers for SPTSSB
 Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat SPTSSB Search GeneGlobe Interaction Network for SPTSSB
 Search Regulatory tfbs for SPTSSB
 GenScript Custom Purified and Recombinant Proteins Services for SPTSSB GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for SPTSSB
 GenScript Custom Assay Services for SPTSSB GenScript Custom overexpressing Cell Line Services for SPTSSB
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for SPTSSB (SPTSB)
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 cDNA Clones for SPTSSB
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 SPTSSB lysates
 Search for Antibodies for SPTSSB at Abcam
 See all of Abcam's Antibodies, Kits and Proteins for SPTSSB
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Browse Proteins at Cloud-Clone Corp.
 Browse Antibodies at Cloud-Clone Corp.
 Browse ELISAs at Cloud-Clone Corp.
 Browse CLIAs at Cloud-Clone Corp.



 Browse ESI BIO Cell Lines and PureStem Progenitors for SPTSSB
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPTSSB
 Browse SwitchGear 3'UTR luciferase reporter plasmids for SPTSSB
 Browse SwitchGear Promoter luciferase reporter plasmids for SPTSSB
 Search ThermoFisher Antibodies for SPTSSB
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPTSSB
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPTSSB
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SPTSSB
 Search LSBio for Antibodies for SPTSSB
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      SPTSSB gene at Home site.
Version: 3.12.142 28 July 2014
hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4