Aliases for SPTSSB Gene
External Ids for SPTSSB Gene
Previous HGNC Symbols for SPTSSB Gene
Previous GeneCards Identifiers for SPTSSB Gene
Serine palmitoyltransferase (SPT; EC 220.127.116.11) catalyzes the first committed and rate-limiting step in sphingolipid biosynthesis. SSSPTB is a small SPT subunit that stimulates SPT activity and confers acyl-CoA preference to the SPT catalytic heterodimer of SPTLC1 (MIM 605712) and either SPTLC2 (MIM 605713) or SPTLC3 (MIM 611120) (Han et al., 2009 [PubMed 19416851]).[supplied by OMIM, Nov 2010]
GeneCards Summary for SPTSSB Gene
SPTSSB (Serine Palmitoyltransferase Small Subunit B) is a Protein Coding gene. Among its related pathways are Metabolism and Sphingolipid metabolism. GO annotations related to this gene include serine C-palmitoyltransferase activity. An important paralog of this gene is SPTSSA.
UniProtKB/Swiss-Prot for SPTSSB Gene
Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference, complexes with this subunit showing a clear preference for longer acyl-CoAs. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference. May play a role in signal transduction.