Aliases for SPTSSA Gene
External Ids for SPTSSA Gene
Previous HGNC Symbols for SPTSSA Gene
Previous GeneCards Identifiers for SPTSSA Gene
Serine palmitoyltransferase (SPT; EC 220.127.116.11) catalyzes the first committed and rate-limiting step in sphingolipid biosynthesis. SSSPTA is a small SPT subunit that stimulates SPT activity and confers acyl-CoA preference to the SPT catalytic heterodimer of SPTLC1 (MIM 605712) and either SPTLC2 (MIM 605713) or SPTLC3 (MIM 611120) (Han et al., 2009 [PubMed 19416851]).[supplied by OMIM, Nov 2010]
GeneCards Summary for SPTSSA Gene
SPTSSA (Serine Palmitoyltransferase, Small Subunit A) is a Protein Coding gene. Among its related pathways are ceramide de novo biosynthesis. GO annotations related to this gene include serine C-palmitoyltransferase activity. An important paralog of this gene is SPTSSB.
UniProtKB/Swiss-Prot for SPTSSA Gene
Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA.