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Aliases for SPTSSA Gene

Aliases for SPTSSA Gene

  • Serine Palmitoyltransferase, Small Subunit A 2 3
  • Small Subunit Of Serine Palmitoyltransferase A 2 3 4
  • C14orf147 3 4 6
  • SSSPTA 3 4 6
  • Serine Palmitoyltransferase Small Subunit A 3
  • Chromosome 14 Open Reading Frame 147 2

External Ids for SPTSSA Gene

Previous HGNC Symbols for SPTSSA Gene

  • C14orf147

Previous GeneCards Identifiers for SPTSSA Gene

  • GC14M034902

Summaries for SPTSSA Gene

Entrez Gene Summary for SPTSSA Gene

  • Serine palmitoyltransferase (SPT; EC 2.3.1.50) catalyzes the first committed and rate-limiting step in sphingolipid biosynthesis. SSSPTA is a small SPT subunit that stimulates SPT activity and confers acyl-CoA preference to the SPT catalytic heterodimer of SPTLC1 (MIM 605712) and either SPTLC2 (MIM 605713) or SPTLC3 (MIM 611120) (Han et al., 2009 [PubMed 19416851]).[supplied by OMIM, Nov 2010]

GeneCards Summary for SPTSSA Gene

SPTSSA (Serine Palmitoyltransferase, Small Subunit A) is a Protein Coding gene. Among its related pathways are ceramide de novo biosynthesis. GO annotations related to this gene include serine C-palmitoyltransferase activity. An important paralog of this gene is SPTSSB.

UniProtKB/Swiss-Prot for SPTSSA Gene

  • Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPTSSA Gene

Genomics for SPTSSA Gene

Genomic Location for SPTSSA Gene

Start:
34,432,789 bp from pter
End:
34,462,356 bp from pter
Size:
29,568 bases
Orientation:
Minus strand

Genomic View for SPTSSA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPTSSA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPTSSA Gene

No data available for Regulatory Elements for SPTSSA Gene

Proteins for SPTSSA Gene

  • Protein details for SPTSSA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969W0-SPTSA_HUMAN
    Recommended name:
    Serine palmitoyltransferase small subunit A
    Protein Accession:
    Q969W0
    Secondary Accessions:
    • B2RD54
    • D3DS93
    • Q8WTZ7

    Protein attributes for SPTSSA Gene

    Size:
    71 amino acids
    Molecular mass:
    8466 Da
    Quaternary structure:
    • Interacts with SPTLC1; the interaction is direct. Component of the serine palmitoyltransferase (SPT) complex, composed of SPTLC1, either SPTLC2 or SPTLC3, and either SPTSSA or SPTSSB.
    SequenceCaution:
    • Sequence=AAH16805.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH16808.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH21701.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH68480.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG37801.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for SPTSSA Gene

Proteomics data for SPTSSA Gene at MOPED

Post-translational modifications for SPTSSA Gene

No Post-translational modifications

Other Protein References for SPTSSA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPTSSA Gene

Domains for SPTSSA Gene

Protein Domains for SPTSSA Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q969W0

UniProtKB/Swiss-Prot:

SPTSA_HUMAN :
  • Q969W0
Family:
  • Belongs to the SPTSS family. SPTSSA subfamily.
genes like me logo Genes that share domains with SPTSSA: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for SPTSSA Gene

Function for SPTSSA Gene

Molecular function for SPTSSA Gene

UniProtKB/Swiss-Prot Function: Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA.

Gene Ontology (GO) - Molecular Function for SPTSSA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004758 contributes_to serine C-palmitoyltransferase activity IDA 19416851
GO:0005515 protein binding IPI 19416851
genes like me logo Genes that share ontologies with SPTSSA: view

Animal Model Products

CRISPR Products

miRNA for SPTSSA Gene

miRTarBase miRNAs that target SPTSSA

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPTSSA

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SPTSSA Gene

Localization for SPTSSA Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPTSSA Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for SPTSSA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0017059 serine C-palmitoyltransferase complex IDA 19416851
genes like me logo Genes that share ontologies with SPTSSA: view

No data available for Subcellular locations from COMPARTMENTS for SPTSSA Gene

Pathways for SPTSSA Gene

SuperPathways for SPTSSA Gene

genes like me logo Genes that share pathways with SPTSSA: view

Pathways by source for SPTSSA Gene

1 BioSystems pathway for SPTSSA Gene

UniProtKB/Swiss-Prot Q969W0-SPTSA_HUMAN

  • Pathway: Lipid metabolism; sphingolipid metabolism

Gene Ontology (GO) - Biological Process for SPTSSA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030148 sphingolipid biosynthetic process TAS 19416851
genes like me logo Genes that share ontologies with SPTSSA: view

Transcripts for SPTSSA Gene

mRNA/cDNA for SPTSSA Gene

(299) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPTSSA Gene

Serine palmitoyltransferase, small subunit A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPTSSA

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPTSSA Gene

No ASD Table

Relevant External Links for SPTSSA Gene

GeneLoc Exon Structure for
SPTSSA
ECgene alternative splicing isoforms for
SPTSSA

Expression for SPTSSA Gene

mRNA expression in normal human tissues for SPTSSA Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SPTSSA Gene

SOURCE GeneReport for Unigene cluster for SPTSSA Gene Hs.740577

genes like me logo Genes that share expressions with SPTSSA: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SPTSSA Gene

Orthologs for SPTSSA Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPTSSA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPTSSA 35
  • 99.53 (n)
  • 100 (a)
SPTSSA 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SPTSSA 35
  • 95.1 (n)
  • 100 (a)
SPTSSA 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPTSSA 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sptssa 35
  • 91.08 (n)
  • 98.59 (a)
Sptssa 16
Sptssa 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SPTSSA 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sptssa 35
  • 90.61 (n)
  • 98.59 (a)
chicken
(Gallus gallus)
Aves SPTSSA 35
  • 87.75 (n)
  • 95.59 (a)
SPTSSA 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPTSSA 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sptssa 35
  • 80.6 (n)
  • 88.06 (a)
Str.8281 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8612 35
zebrafish
(Danio rerio)
Actinopterygii sptssa 35
  • 73.53 (n)
  • 82.35 (a)
sptssa 36
  • 82 (a)
OneToOne
wufb60h11 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3848 36
  • 18 (a)
OneToMany
Species with no ortholog for SPTSSA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPTSSA Gene

ENSEMBL:
Gene Tree for SPTSSA (if available)
TreeFam:
Gene Tree for SPTSSA (if available)

Paralogs for SPTSSA Gene

Paralogs for SPTSSA Gene

Selected SIMAP similar genes for SPTSSA Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SPTSSA Gene

genes like me logo Genes that share paralogs with SPTSSA: view

Variants for SPTSSA Gene

Sequence variations from dbSNP and Humsavar for SPTSSA Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs8497 -- 34,433,028(-) TTTTT(G/T)TTAAA utr-variant-3-prime
rs2002517 -- 34,452,926(-) CATGT(G/T)TTCAA intron-variant
rs2003043 -- 34,452,201(+) agatc(A/G)cgcca intron-variant
rs2383633 -- 34,439,242(+) CCTAA(C/G)CAAGA intron-variant
rs2383634 -- 34,453,351(+) CATTT(G/T)TACCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPTSSA Gene

Variant ID Type Subtype PubMed ID
nsv528989 CNV Gain 19592680
nsv901600 CNV Gain 21882294

Relevant External Links for SPTSSA Gene

HapMap Linkage Disequilibrium report
SPTSSA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPTSSA Gene

Disorders for SPTSSA Gene

No disorders were found for SPTSSA Gene.

No data available for UniProtKB/Swiss-Prot for SPTSSA Gene

Publications for SPTSSA Gene

  1. Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities. (PMID: 19416851) Han G. … Dunn T.M. (Proc. Natl. Acad. Sci. U.S.A. 2009) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for SPTSSA Gene

Sources for SPTSSA Gene

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