SPTLC2 Gene
protein-coding GIFtS: 64
GCID: GC14M077973
|
|
serine palmitoyltransferase, long chain base subunit 2
| |
Aliases
for SPTLC2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Serine Palmitoyltransferase, Long Chain Base Subunit 21 2 | | EC 2.3.1.503 8 | | LCB21 2 3 5 | | HSN1C2 5 | | KIAA05261 3 5 | | NSAN1C2 5 | | LCB2A1 2 | | SPT22 5 | | HLCB2a1 | | Serine Palmitoyltransferase 22 | | Long Chain Base Biosynthesis Protein 2a2 3 | | Serine Palmitoyltransferase, Subunit II2 | | Serine-Palmitoyl-CoA Transferase 22 3 | | LCB2a3 | | LCB 22 3 | | Long Chain Base Biosynthesis Protein 23 | | SPT 22 3 | | EC 2.3.18 |
Export aliases for SPTLC2 gene to outside databasesPrevious GC identifers: GC14M075479 GC14M071790 GC14M075963 GC14M077043 GC14M058139 |
Summaries
for SPTLC2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SPTLC2:
This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consistsof two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes thepyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations inthis gene were identified in patients with hereditary sensory neuropathy type I. (provided by RefSeq, Mar 2011)
UniProtKB/Swiss-Prot: SPTC2_HUMAN, O15270Function: Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core.The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. TheSPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complexdisplays a preference for C18-CoA substrate
Gene Wiki entry for SPTLC2
|
Genomic Views
for SPTLC2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SPTLC2 gene promoter:
STAT1 LHX3b/Lhx3b C/EBPbeta Elk-1 Pax-6 C/EBPalpha RORalpha1 LHX3a/Lhx3a ZID
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPTLC2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPTLC2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q24.3 Ensembl cytogenetic band: 14q24.3 HGNC cytogenetic band: 14q24.3SPTLC2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M077973: view genomic region
(about GC identifiers)
Start:
|
77,972,340 bp from pter |
End:
|
78,083,116 bp from pter |
Size:
|
110,777 bases |
Orientation:
|
minus strand |
|
Proteins
for SPTLC2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPTC2_HUMAN, O15270 (See
protein sequence)Recommended Name: Serine palmitoyltransferase 2 Size: 562 amino acids; 62924 Da
Cofactor: Pyridoxal phosphate (By similarity)
Subunit: Heterodimer with SPTLC1. Component of the serine palmitoyltransferase (SPT) complex, composed of LCB1/SPTLC1,LCB2 (SPTLC2 or SPTLC3) and ssPT (SPTSSA and SPTSSB)
Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity)
Sequence caution: Sequence=BAA25452.2; Type=Erroneous initiation;
Secondary accessions: Q16685Explore the universe of human proteins at neXtProt for SPTLC2: NX_O15270
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O15270
4/16 DME Specific Peptides for SPTLC2 (O15270) (see all 16)
SPTLC2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004854.1
ENSEMBL proteins: ENSP00000216484 ENSP00000451029 ENSP00000452189 Reactome Protein details: O15270
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
SPTLC2 for ontologies About GeneDecksing
SPTLC2 Antibody Products:
Assay Products for SPTLC2: |
Protein
Domains /
Families
for SPTLC2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SPTLC2 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O15270ProtoNet protein and cluster: O15270 1 Blocks protein family: IPB001917 Aminotransferase
UniProtKB/Swiss-Prot: SPTC2_HUMAN, O15270Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family |
Function
for SPTLC2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SPTC2_HUMAN, O15270Function: Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core.The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. TheSPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complexdisplays a preference for C18-CoA substrateCatalytic activity: Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO(2)Enzyme Numbers (IUBMB): EC 2.3.1.501 2 EC 2.3.12
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPTLC2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPTLC2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SPTLC2 (NM_004863) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPTLC2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPTLC2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPTLC2 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003824 | catalytic activity |
-- | -- | | GO:0004758 | serine C-palmitoyltransferase activity |
IDA | -- | | GO:0030170 | pyridoxal phosphate binding |
IEA | -- |
SPTLC2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SPTLC2:
Animal Models:
Mouse knock-out Sptlc2tm1Jia for SPTLC2
4 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Sptlc2):
SPTLC2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SPTLC2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Sphingolipid metabolism | | | 2 | Metabolism | | | 3 | ceramide biosynthesis | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for SPTLC2
4 
Reactome Pathways for SPTLC2
2 
Kegg Pathways (Kegg details for SPTLC2):
UniProtKB/Swiss-Prot: SPTC2_HUMAN, O15270Pathway: Lipid metabolism; sphingolipid metabolism
SPTLC2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPTLC2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 24)
5/72 Interacting proteins for SPTLC2 (O152703 ENSP000002164844) via UniProtKB, MINT, STRING, and/or I2D (see all 72)
About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006644 | phospholipid metabolic process |
TAS | -- | | GO:0006665 | sphingolipid metabolic process |
TAS | -- | | GO:0006686 | sphingomyelin biosynthetic process |
IEA | -- | | GO:0030148 | sphingolipid biosynthetic process |
TAS | -- | | GO:0044281 | small molecule metabolic process |
TAS | -- |
SPTLC2 for ontologies About GeneDecksing
|
Drugs & Compounds
for SPTLC2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SPTLC2 for compounds About GeneDecksing
 Browse Tocris compounds for SPTLC2
6 HMDB Compounds for SPTLC2 About this table
2 DrugBank Compounds for SPTLC2 About this table
3 Novoseek chemical compound relationships for SPTLC2 gene About this table
Search CenterWatch for drugs/clinical trials and news about SPTLC2 / SPTC2
|
Transcripts
for SPTLC2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPTLC2 gene: NM_004863.3 Unigene Cluster for SPTLC2: Serine palmitoyltransferase, long chain base subunit 2 Hs.435661 [show with all ESTs]Unigene Representative Sequence: NM_0048636 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000216484(uc001xub.3) ENST00000556607 ENST00000554901 ENST00000554365
ENST00000556264 ENST00000557566
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPTLC2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPTLC2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SPTLC2 (NM_004863) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPTLC2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPTLC2 |
Additional cDNA sequence: AB011098.1 BC005123.2 U15555.1 Y08686.1 10 DOTS entries: DT.453015 DT.120782936 DT.116842 DT.86854487 DT.86854488 DT.95105704 DT.86857931 DT.91748671 DT.120782948 DT.91836960 24/284 AceView cDNA sequences (see all 284): BM990439 BF939455 W93177 AI079531 BM772247 N93642 AA256515 AA642946 BM831362 AA485092 BQ025633 NM_004863 CA945105 BU607593 BM821800 AI862158 BM831461 BM822292 AI308235 BF221558 BM723775 CR616151 AW273277 H98998
GeneLoc Exon Structure
|
Expression
for SPTLC2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPTLC2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTGCCAAAA
About this image
See SPTLC2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPTLC2
SOURCE GeneReport for Unigene cluster: Hs.435661
UniProtKB/Swiss-Prot: SPTC2_HUMAN, O15270Tissue specificity: Widely expressed
SABiosciences Custom PCR Arrays for SPTLC2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPTLC2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPTLC2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPTLC2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPTLC2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPTLC2 |
Orthologs
for SPTLC2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SPTLC2 gene from 9/41 species (see all 41) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SPTLC21 |
serine palmitoyltransferase, long chain base subunit more |
79.56(n)
89.21(a) |
|
423379 NM_001006483.1 NP_001006483.1 |
lizard
(Anolis carolinensis) |
Reptilia |
SPTLC26 |
-- |
88(a) |
1 ↔ 1 |
1(20565074-20627574) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.23382 |
Xenopus laevis transcribed sequence with moderate similarity more |
76.4(n) |
|
BU903829.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.168852 |
Danio rerio cDNA clone IMAGE3816160, partial cds |
77.48(n) |
|
BC056779.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
lace1 , 3 |
serine C-palmitoyltransferase3
CG4162-PA1 |
56(a)3
59.2(n)1
57.93(a)1 |
|
35D23
349101 NM_057266.41 NP_476614.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
F43H9.2a3
sptl-21 |
serine palmtoyltransferase3
Protein SPTL-21 |
55(a)
(best of 3)3
57.79(n)1
55.33(a)1 |
|
V(8021762-8024171)3
2666461 NM_072663.31 NP_505064.11 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
LCB2(YDR062W)4
LCB21 |
Component of serine palmitoyltransferase, responsible more4
Lcb2p1 |
53.24(n)1
48.47(a)1 |
|
4(576474-578159)4
8516341, 4 NP_010347.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT3G487906LCB26(see all 3) |
serine palmitoyltransferase(see all 3) |
52(a)51(a)(see all 3) |
many ↔ manymany ↔ many(see all 3) |
3(18093404-18095181) 5(7981641-7985398) |
rice
(Oryza sativa) |
Liliopsida |
NM_190004.12 |
-- |
73.52(n) |
|
NM_190004.1 |
ENSEMBL Gene Tree for SPTLC2 (if available)
TreeFam Gene Tree for SPTLC2 (if available) |
Paralogs
for SPTLC2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SPTLC2 gene
- SPTLC32
1 SIMAP similar gene for SPTLC2 using alignment to 4 protein entries: SPTC2_HUMAN (see all proteins):SPTLC3
SPTLC2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for SPTLC2
PGOHUM00000243459
|
Genomic Variants
for SPTLC2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SPTLC2 (77972340 - 78083116 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for SPTLC2
2 CNVs: 3943 5754
1 Inversion: 59721
Human Gene Mutation Database (HGMD): SPTLC2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPTLC2 |
|
Disorders
/ Diseases
for SPTLC2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SPTLC2 for disorders About GeneDecksing
OMIM gene information: 605713
OMIM disorders: 613640
UniProtKB/Swiss-Prot: SPTC2_HUMAN, O15270
Defects in SPTLC2 are the cause of hereditary sensory and autonomic neuropathy type 1C (HSAN1C) [MIM:613640].It is a form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group ofdisorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by prominent sensoryabnormalities with a variable degree of motor and autonomic dysfunction. The neurological phenotype is oftencomplicated by severe infections, osteomyelitis, and amputations. HSAN1C symptoms include loss of touch and vibrationin the feet, dysesthesia and severe panmodal sensory loss in the upper and lower limbs, distal lower limb sensory losswith ulceration and osteomyelitis, and distal muscle weakness
10  diseases for SPTLC2: About MalaCardshereditary sensory neuropathy neuropathy autonomic dysfunction autonomic neuropathy
peripheral neuropathy osteomyelitis tuberculosis pancreatitis
malaria mycobacterium tuberculosis
1 disease from the University of Copenhagen DISEASES database for SPTLC2:Peripheral neuropathy 2 Novoseek disease relationships for SPTLC2 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| neuropathy, hereditary sensory, type i |
90.9 |
1 |
11781309 (1) |
| sensory neuropathy hereditary |
86.5 |
2 |
12207934 (1) |
Human Genome Epidemiology (HuGE) Navigator: SPTLC2 (1 document)
Export disorders for SPTLC2 gene to outside databases
|
Publications
for SPTLC2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPTLC2 gene, integrated from 9 sources (see all 40):
(articles sorted by number of sources associating them with SPTLC2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Sphingolipid synthesis: identification and characterization of mammalian cDNAs encoding the Lcb2 subunit of serine palmitoyltransferase. (PubMed id 8921873)1, 2, 3, 9 Nagiec M.M.... Dickson R.C. (1996)
- Human and murine serine-palmitoyl-CoA transferase. Cloning, expression and characterization of the key enzyme in sphingolipid synthesis. (PubMed id 9363775)1, 2, 3, 9 Weiss B. and Stoffel W. (1997)
- Mutations in the SPTLC2 subunit of serine palmitoyltr ansferase cause hereditary sensory and autonomic neuropathy type I. (PubMed id 20920666)1, 2 Rotthier A....Timmerman V. (2010)
- Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities. (PubMed id 19416851)1, 2 Han G.... Dunn T.M. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
- Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2 Nagase T....Ohara O. (1998)
- A molecular inventory of human pancreatic islets: sequence analysis of 1000 cDNA clones. (PubMed id 7506601)1, 2 Takeda J.... Bell G.I. (1993)
- Permeability barrier disruption increases the level of serine palmitoyltransferase in human epidermis. (PubMed id 12445191)1, 9 Stachowitz S....Behrendt H. (2002)
- Exclusion of serine palmitoyltransferase long chain base subunit 2 (SPTLC2) as a common cause for hereditary sensory neuropathy. (PubMed id 12207934)1, 9 Dawkins J.L....Nicholson G.A. (2002)
|
External Searches for SPTLC2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SPTLC2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SPTLC2 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing SPTLC2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SPTLC2 | Pharmacogenomics, SNPs, Pathways |
|
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About This Section
| Patent Information for SPTLC2 gene:
Search GeneIP for patents involving SPTLC2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SPTLC2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SPTLC2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPTLC2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPTLC2 | | | OriGene Protein Over-expression Lysate for SPTLC2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SPTLC2 | | OriGene 3'-UTR Clone for SPTLC2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPTLC2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPTLC2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SPTLC2 | | OriGene Custom Protein Services for SPTLC2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPTLC2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPTLC2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPTLC2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPTLC2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPTLC2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPTLC2 |
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| | | | Search Tocris compounds for SPTLC2 |
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 | | | SPTLC2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPTLC2 |
|  |  |  | | | | ThermoFisher Antibodies for SPTLC2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPTLC2 |
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