SPTB Gene
protein-coding GIFtS: 59
GCID: GC14M065213
|
|
spectrin, beta, erythrocytic
| |
Aliases
for SPTB gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Spectrin, Beta, Erythrocytic1 2 | | HSPTB12 | | Beta-I Spectrin2 3 | | Membrane Cytoskeletal Protein2 | | EL32 5 | | Spectrin Beta Chain, Erythrocyte2 | | HS22 5 | | Spectrin Beta Chain, Erythrocytic2 | | SPH22 5 | | SPTB13 |
Export aliases for SPTB gene to outside databasesPrevious GC identifers: GC14M062543 GC14M059009 GC14M063205 GC14M064284 GC14M045384 |
Summaries
for SPTB gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SPTB:
This locus encodes a member of the spectrin gene family. Spectrin proteins, along with ankyrin, play a role in cellmembrane organization and stability. The protein encoded by this locus functions in stability of erythrocytemembranes, and mutations in this gene have been associated with spherocytosis type 2, hereditary elliptocytosis, andneonatal hemolytic anemia. Alternatively spliced transcript variants have been described. (provided by RefSeq, Nov2009)
UniProtKB/Swiss-Prot: SPTB1_HUMAN, P11277Function: Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. Itassociates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane
Gene Wiki entry for SPTB
|
Genomic Views
for SPTB gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SPTB gene promoter:
HOXA9B HOXA9 N-Myc Ik-2 FOXF2 Zic1 MyoD Olf-1 Meis-1a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPTB
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPTB |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q23-q24.2 Ensembl cytogenetic band: 14q23.3 HGNC cytogenetic band: 14q24.1-q24.2SPTB Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M065213: view genomic region
(about GC identifiers)
Start:
|
65,213,001 bp from pter |
End:
|
65,346,601 bp from pter |
Size:
|
133,601 bases |
Orientation:
|
minus strand |
|
Proteins
for SPTB gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPTB1_HUMAN, P11277 (See
protein sequence)Recommended Name: Spectrin beta chain, erythrocytic Size: 2137 amino acids; 246468 Da
Subunit: Composed of nonhomologous chains, alpha and beta, which aggregate to form dimers, tetramers, and higherpolymers
Subcellular location: Cytoplasm, cytoskeleton. Cytoplasm, cell cortex
Miscellaneous: This complex is anchored to the cytoplasmic face of the plasma membrane via another protein, ankyrin,which binds to beta-spectrin and mediates the binding of the whole complex to a transmembrane protein band 3. Theinteraction of erythrocyte spectrin with other proteins through specific binding domains lead to the formation of anextensive subplasmalemmal meshwork which is thought to be responsible for the maintenance of the biconcave shape ofhuman erythrocytes, for the regulation of plasma membrane components and for the maintenance of the lipid asymmetry ofthe plasma membrane
6 PDB 3D structures from  and Proteopedia  for SPTB:1S35 (3D)
3EDU (3D)
3F57 (3D)
3KBT (3D)
3KBU (3D)
3LBX (3D)
Secondary accessions: Q15510 Q15519Alternative splicing: 3 isoforms: P11277-1 P11277-2 P11277-3 (Due to exon skipping)Explore the universe of human proteins at neXtProt for SPTB: NX_P11277
Post-translational modifications:
The first phosphorylation event occurs on Ser-2114, followed by Ser-2125, Ser-2123, Ser-2128, Ser-2117, and Thr-21101
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P11277
SPTB Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_000338.3 NP_001020029.1
ENSEMBL proteins: ENSP00000451324 ENSP00000451752 ENSP00000374371 ENSP00000374370 ENSP00000374372 ENSP00000443882 Reactome Protein details: P11277
Human Recombinant Protein Products:
Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11): About this table
SPTB for ontologies About GeneDecksing
SPTB Antibody Products:
Assay Products for SPTB: |
Protein
Domains /
Families
for SPTB gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SPTB for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P11277ProtoNet protein and cluster: P11277 3 Blocks protein families: IPB001589 Actin-binding IPB001715 Calponin-like actin-binding IPB002017 Spectrin repeat
UniProtKB/Swiss-Prot: SPTB1_HUMAN, P11277Similarity: Belongs to the spectrin familySimilarity: Contains 2 CH (calponin-homology) domainsSimilarity: Contains 17 spectrin repeats |
Function
for SPTB gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SPTB1_HUMAN, P11277Function: Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. Itassociates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane Genatlas biochemistry entry for SPTB:spectrin,beta,erythrocytic,intermediate filament associated protein (IFAP,type III),dimerizing andheteropolymerizing,components of the core structure of the membrane skeleton
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPTB (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPTB (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): SPTB (NM_000347) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPTB | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SPTB |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPTB |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
SPTB for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for SPTB:
Animal Models:
11 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Sptb):
SPTB for phenotypes About GeneDecksing
|
Pathways & Interactions
for SPTB gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Axon guidance | | | 2 | Sertoli-Sertoli Cell Junction Dynamics | | | 3 | Interaction between L1 and Ankyrins | | | 4 | NCAM signaling for neurite out-growth | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SPTB
5 
Reactome Pathways for SPTB
SPTB for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SPTB
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/31 Interacting proteins for SPTB (P112771, 3 ENSP000003743724) via UniProtKB, MINT, STRING, and/or I2D (see all 31)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
SPTB for ontologies About GeneDecksing
|
Drugs & Compounds
for SPTB gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SPTB for compounds About GeneDecksing
 Browse Tocris compounds for SPTB
10/16 Novoseek chemical compound relationships for SPTB gene (see all 16) About this table
Search CenterWatch for drugs/clinical trials and news about SPTB / SPTB1
|
Transcripts
for SPTB gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPTB gene (2 alternative transcripts): NM_000347.5 NM_001024858.2 Unigene Cluster for SPTB: Spectrin, beta, erythrocytic Hs.417303 [show with all ESTs]Unigene Representative Sequence: NM_0010248589 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000342835 ENST00000553938 ENST00000556227 ENST00000556626 ENST00000389721
ENST00000389720 ENST00000542694 ENST00000389722(uc010aqi.3 uc001xhr.3 uc001xhs.3)
ENST00000542895(uc001xht.3 uc001xhu.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPTB (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPTB (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): SPTB (NM_000347) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPTB | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SPTB |
Additional cDNA sequence: AB209415.1 AF465439.1 AK094815.1 AK126627.1 BC010434.1 BC136284.1 BC136285.1 BX248270.1 J05500.1 M18054.1 M37884.1 M37885.1 M57948.1 S42560.1 X59510.1 X59511.1 9 DOTS entries: DT.315853 DT.453814 DT.97839158 DT.100748529 DT.95271025 DT.95271026 DT.97837819 DT.102833620 DT.40112916 24/131 AceView cDNA sequences (see all 131): BM727714 AJ573004 BM510640 M37885 AI093063 BX280800 BU782581 Z42092 CK300348 CA429242 T28114 BX508326 BX248270 BU786903 BC010434 BM681142 BX354394 AA323538 BM714051 AK126627 F28922 AF465439 NM_000347 AA992469
GeneLoc Exon Structure
|
Expression
for SPTB gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPTB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGGGAAACA
About this image
See SPTB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPTB
SOURCE GeneReport for Unigene cluster: Hs.417303
SABiosciences Expression via Pathway-Focused PCR Array including SPTB:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPTB
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPTB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPTB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPTB | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPTB |
Orthologs
for SPTB gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SPTB gene from 5/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SPTB1 |
spectrin, beta, erythrocytic |
70.52(n)
63.6(a) |
|
769410 XM_003641275.1 XP_003641323.1 |
lizard
(Anolis carolinensis) |
Reptilia |
SPTB6 |
-- |
70(a) |
1 ↔ 1 |
1(93839104-93917294) |
zebrafish
(Danio rerio) |
Actinopterygii |
sptb1 |
spectrin, beta, erythrocytic |
64.65(n)
63.2(a) |
|
58040 NM_131525.1 NP_571600.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
&bgr;-Spec3 |
neuromuscular synaptic transmission actin
binding |
50(a) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
unc-703 |
spectrin beta chain |
48(a)
(best of 2) |
|
V(6883990-6892937) -- |
ENSEMBL Gene Tree for SPTB (if available)
TreeFam Gene Tree for SPTB (if available) |
Paralogs
for SPTB gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SPTB gene
- ACTN42 SPTBN22 SPTA12 SYNE22 SPTBN42 SPTBN12 SPTBN52 ACTN22
- SPTAN12 ACTN12 SYNE12 CLMN2
16 SIMAP similar genes for SPTB using alignment to 4 protein entries: SPTB1_HUMAN (see all proteins):HSpTB1 MACF1 SPTBN1 SPTBN2 DKFZp434J0328 DMD
SPTBN3 SPNB4 SPTBN4 ACF7 SPTA1 SYNE2
ACTN4 SPTAN1 ACTN1 ACTN2
SPTB for paralogs About GeneDecksing
|
Genomic Variants
for SPTB gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SPTB (65213001 - 65346601 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for SPTB
2 CNVs: 49389 3053
1 Indel: 60154
Human Gene Mutation Database (HGMD): SPTB
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPTB |
|
Disorders
/ Diseases
for SPTB gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SPTB for disorders About GeneDecksing
OMIM gene information: 182870
OMIM disorders: --
UniProtKB/Swiss-Prot: SPTB1_HUMAN, P11277
Defects in SPTB are the cause of elliptocytosis type 3 (EL3) [MIM:182870]. EL3 is a Rhesus-unlinked form ofhereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterizedby variable hemolytic anemia and elliptical or oval red cell shape Defects in SPTB are the cause of spherocytosis type 2 (SPH2) [MIM:182870]; also known as hereditaryspherocytosis type 2 (HS2). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia andcharacterized by numerous abnormally shaped erythrocytes which are generally spheroidal. SPH2 is characterized bysevere hemolytic anemia. Inheritance is autosomal dominant
20/34  diseases for SPTB (see all 34): About MalaCardsanemia, neonatal hemolytic, fatal and near-fatal spherocytosis, type 2 spherocytosis elliptocytosis
hereditary elliptocytosis hemolytic anemia anemia pyropoikilocytosis hereditary
pyropoikilocytosis elliptocytosis 3 beta thalassemia muscular dystrophy
hydrops fetalis duchenne muscular dystrophy vacuolar myopathy otopalatodigital syndrome
hereditary spherocytosis centronuclear myopathy gnathomiasis dyserythropoietic anemia
3 diseases from the University of Copenhagen DISEASES database for SPTB:Hereditary elliptocytosis Anemia Gnathomiasis 10/20 Novoseek disease relationships for SPTB gene (see all 20) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| elliptocytosis hereditary |
93.7 |
19 |
1498324 (2), 1840591 (1), 10772878 (1), 2056132 (1) (see all 18) |
| spherocytosis hereditary |
91.2 |
16 |
8102379 (2), 8675627 (1), 16617750 (1), 11154235 (1) (see all 13) |
| pyropoikilocytosis, hereditary |
86.9 |
1 |
17192394 (1) |
| spherocytosis |
77 |
2 |
19538529 (1), 7803294 (1) |
| anemia hemolytic congenital |
69.7 |
1 |
8813717 (1) |
| anemia hemolytic |
68.7 |
1 |
9005995 (1) |
| muscular dystrophy duchenne |
55.8 |
7 |
8208414 (2), 1406935 (1), 10867799 (1), 8960314 (1) (see all 6) |
| hemolysis |
54.4 |
4 |
11060238 (2), 16728274 (1), 16096844 (1) |
| protein deficiency |
42.3 |
1 |
14636652 (1) |
| muscular dystrophy becker |
38.8 |
1 |
8208414 (1) |
Human Genome Epidemiology (HuGE) Navigator: SPTB (9 documents)
Export disorders for SPTB gene to outside databases
|
Publications
for SPTB gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPTB gene, integrated from 9 sources (see all 228):
(articles sorted by number of sources associating them with SPTB) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Assignment of the gene for beta-spectrin (SPTB) to chromosome 14q23----q24.2 by in situ hybridization. (PubMed id 2209094)1, 3, 9 Fukushima Y....Shows T.B. (1990)
- A splice site mutation of the beta-spectrin gene causing exon skipping in hereditary elliptocytosis associated with a truncated beta-spectrin chain. (PubMed id 1840591)1, 2, 9 Gallagher P.G....Forget B.G. (1991)
- Spectrin Rouen (beta 220-218), a novel shortened beta-chain variant in a kindred with hereditary elliptocytosis. Characterization of the molecular defect as exon skipping due to a splice site mutation. (PubMed id 2056132)1, 2, 9 Garbarz M....Forget B.G. (1991)
- In vivo phosphorylation of human erythrocyte spectrin occurs in a sequential manner. (PubMed id 15065869)1, 2, 9 Tang H.Y. and Speicher D.W. (2004)
- Beta spectrin Kissimmee: a spectrin variant associated with autosomal dominant hereditary spherocytosis and defective binding to protein 4.1. (PubMed id 8102379)1, 2, 9 Becker P.S.... Forget B.G. (1993)
- Full-length sequence of the cDNA for human erythroid beta-spectrin. (PubMed id 2195026)1, 2, 9 Winkelmann J.C....Forget B.G. (1990)
- Beta spectrin in human skeletal muscle. Tissue-specific differential processing of 3' beta spectrin pre-mRNA generates a beta spectrin isoform with a unique carboxyl terminus. (PubMed id 2243099)1, 2, 9 Winkelmann J.C.... Forget B.G. (1990)
- Spectrin mutations in hereditary elliptocytosis and hereditary spherocytosis. (PubMed id 8844207)1, 2, 9 Maillet P.... Delaunay J. (1996)
- Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
- Recurrent fatal hydrops fetalis associated with a nucleotide substitution in the erythrocyte beta-spectrin gene. (PubMed id 7883966)1, 2 Gallagher P.G.... Forget B.G. (1995)
|
External Searches for SPTB gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SPTB gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SPTB gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPTB gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for SPTB gene:
Search GeneIP for patents involving SPTB
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SPTB gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for SPTB | | OriGene shRNA RFP for SPTB | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPTB | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPTB | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SPTB | | OriGene 3'-UTR Clone for SPTB | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPTB | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPTB | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SPTB | | OriGene Custom Protein Services for SPTB | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPTB | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPTB | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPTB | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPTB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPTB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPTB |
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| | | | Search Tocris compounds for SPTB |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPTB |
|  |  |  | | | | ThermoFisher Antibody for SPTB |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SPTB |
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