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Aliases for SPTAN1 Gene

Aliases for SPTAN1 Gene

  • Spectrin Alpha, Non-Erythrocytic 1 2 3 5
  • Spectrin, Non-Erythroid Alpha Subunit 3 4
  • Fodrin Alpha Chain 3 4
  • Alpha-II Spectrin 3 4
  • Alpha-Fodrin 2 3
  • SPTA2 3 4
  • NEAS 3 4
  • Spectrin Alpha Chain, Non-Erythrocytic 1 3
  • Spectrin, Non-Erythroid Alpha Chain 3
  • EIEE5 3

External Ids for SPTAN1 Gene

Previous GeneCards Identifiers for SPTAN1 Gene

  • GC09P122429
  • GC09P122961
  • GC09P124768
  • GC09P126690
  • GC09P126661
  • GC09P128394
  • GC09P130355
  • GC09P131314
  • GC09P100926

Summaries for SPTAN1 Gene

Entrez Gene Summary for SPTAN1 Gene

  • Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]

GeneCards Summary for SPTAN1 Gene

SPTAN1 (Spectrin Alpha, Non-Erythrocytic 1) is a Protein Coding gene. Diseases associated with SPTAN1 include Epileptic Encephalopathy, Early Infantile, 5 and West Syndrome. Among its related pathways are RET signaling and Apoptosis and survival Caspase cascade. GO annotations related to this gene include calcium ion binding and actin binding. An important paralog of this gene is SPTA1.

UniProtKB/Swiss-Prot for SPTAN1 Gene

  • Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.

Gene Wiki entry for SPTAN1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPTAN1 Gene

Genomics for SPTAN1 Gene

Regulatory Elements for SPTAN1 Gene

Enhancers for SPTAN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G129350 1.8 FANTOM5 Ensembl ENCODE dbSUPER 13.6 +799.9 799934 4.4 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF48 ZNF121 SLC30A9 GLIS2 ENSG00000272593 SPTAN1 LOC105376289 C9orf50 LOC101929314 LOC100129352 LINC01503 RN7SL159P
GH09G128586 1 ENCODE 21.3 +35.2 35206 2.3 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 ZNF121 ZNF143 KDM4B DEK SPTAN1 LOC101929270 LOC101929314 CERCAM ENSG00000280474
GH09G128024 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -523.6 -523630 9.4 HDGF PKNOX1 ZNF133 ZFP64 SIN3A YBX1 ZNF48 ZNF121 CBX5 ZNF143 ENSG00000272696 ENSG00000272593 FAM102A SPTAN1 PTRH1 LOC101929314 SLC25A25-AS1 PTGES2-AS1 NAIF1 SLC25A25
GH09G128770 1.2 ENCODE 13.5 +219.1 219058 2.7 MLX CREB3L1 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 NFYC ZNF610 ENSG00000272696 ENSG00000272593 SPTAN1 LOC101929314 LOC101929270 SPOUT1 CDK9 LOC100129352 ENDOG ZER1
GH09G128065 1.4 ENCODE dbSUPER 10.8 -485.0 -484963 4.6 HDGF PKNOX1 FOXA2 CREB3L1 ARNT WRNIP1 ZFP64 ARID4B SIN3A ZBTB7B LOC101929314 ENSG00000272696 ANGPTL2 LOC102723566 RPL12 ZNF79 SPOUT1 ENSG00000272593 URM1 SPTAN1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPTAN1 on UCSC Golden Path with GeneCards custom track

Promoters for SPTAN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000241884 442 2401 HDGF ARNT ARID4B SIN3A ZNF766 ZNF207 FOS KLF13 SP3 REST

Genomic Location for SPTAN1 Gene

Chromosome:
9
Start:
128,552,558 bp from pter
End:
128,633,665 bp from pter
Size:
81,108 bases
Orientation:
Plus strand

Genomic View for SPTAN1 Gene

Genes around SPTAN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPTAN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPTAN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPTAN1 Gene

Proteins for SPTAN1 Gene

  • Protein details for SPTAN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13813-SPTN1_HUMAN
    Recommended name:
    Spectrin alpha chain, non-erythrocytic 1
    Protein Accession:
    Q13813
    Secondary Accessions:
    • Q13186
    • Q15324
    • Q16606
    • Q59EF1
    • Q5VXV5
    • Q5VXV6
    • Q7Z6M5
    • Q9P0V0

    Protein attributes for SPTAN1 Gene

    Size:
    2472 amino acids
    Molecular mass:
    284539 Da
    Quaternary structure:
    • Like erythrocyte spectrin, the spectrin-like proteins are capable of forming dimers which can further associate to tetramers. Interacts (via C-terminal spectrin repeats) with TRPC4. Interacts with CALM and EMD. Interacts with isoform 1 of ACP1. Identified in a complex with ACTN4, CASK, IQGAP1, MAGI2, NPHS1 and SPTBN1. Interacts with SHANK3 (via ANK repeats).
    SequenceCaution:
    • Sequence=BAD93097.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SPTAN1 Gene

    Alternative splice isoforms for SPTAN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPTAN1 Gene

Post-translational modifications for SPTAN1 Gene

  • Phosphorylation of Tyr-1176 decreases sensitivity to cleavage by calpain in vitro.
  • Ubiquitination at Lys1519 and posLast=24262426
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SPTAN1 (SPTAN1)

No data available for DME Specific Peptides for SPTAN1 Gene

Domains & Families for SPTAN1 Gene

Gene Families for SPTAN1 Gene

Graphical View of Domain Structure for InterPro Entry

Q13813

UniProtKB/Swiss-Prot:

SPTN1_HUMAN :
  • Belongs to the spectrin family.
Family:
  • Belongs to the spectrin family.
genes like me logo Genes that share domains with SPTAN1: view

Function for SPTAN1 Gene

Molecular function for SPTAN1 Gene

GENATLAS Biochemistry:
spectrin,alpha,non-erythrocytic 1,intermediate filament associated protein (IFAP,type III),alpha-fodrin,120kDa,candidate autoantigen in primary Sjogren syndrome
UniProtKB/Swiss-Prot Function:
Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.

Gene Ontology (GO) - Molecular Function for SPTAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding TAS,IEA --
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
GO:0005200 structural constituent of cytoskeleton TAS 2307671
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 12571280
genes like me logo Genes that share ontologies with SPTAN1: view
genes like me logo Genes that share phenotypes with SPTAN1: view

Human Phenotype Ontology for SPTAN1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SPTAN1 Gene

MGI Knock Outs for SPTAN1:

Animal Model Products

CRISPR Products

miRNA for SPTAN1 Gene

miRTarBase miRNAs that target SPTAN1

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SPTAN1 Gene

Localization for SPTAN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPTAN1 Gene

Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Expressed along the cell membrane in podocytes and presumptive tubule cells during glomerulogenesis and is expressed along lateral cell margins in tubule cells. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPTAN1 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 5
plasma membrane 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SPTAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005938 cell cortex IEA --
genes like me logo Genes that share ontologies with SPTAN1: view

Pathways & Interactions for SPTAN1 Gene

SuperPathways for SPTAN1 Gene

SuperPathway Contained pathways
1 RET signaling
2 Transport to the Golgi and subsequent modification
3 Apoptotic cleavage of cellular proteins
4 Innate Immune System
5 Sertoli-Sertoli Cell Junction Dynamics
genes like me logo Genes that share pathways with SPTAN1: view

SIGNOR curated interactions for SPTAN1 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for SPTAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0007010 cytoskeleton organization IEA --
GO:0007411 axon guidance TAS --
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with SPTAN1: view

Drugs & Compounds for SPTAN1 Gene

(9) Drugs for SPTAN1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(3) Additional Compounds for SPTAN1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SPTAN1: view

Transcripts for SPTAN1 Gene

Unigene Clusters for SPTAN1 Gene

Spectrin, alpha, non-erythrocytic 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPTAN1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c · 17d ^ 18a · 18b ·
SP1:
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: - - - - - - - - - - - - - - - - - -
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:

ExUns: 18c · 18d ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b · 26c ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30 ^ 31a · 31b ^ 32 ^ 33a · 33b · 33c ^
SP1: - - - -
SP2:
SP3: - - - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: - - -
SP16:
SP17:
SP18:
SP19: -
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:

ExUns: 34 ^ 35 ^ 36a · 36b ^ 37 ^ 38 ^ 39 ^ 40 ^ 41a · 41b ^ 42a · 42b ^ 43 ^ 44 ^ 45a · 45b ^ 46a · 46b ^ 47 ^ 48a · 48b ^ 49 ^ 50a · 50b ^ 51 ^ 52 ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:

ExUns: 53 ^ 54a · 54b ^ 55 ^ 56a · 56b ^ 57a · 57b ^ 58 ^ 59a · 59b ^ 60 ^ 61a ·
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: - - - - -
SP11: -
SP12:
SP13:
SP14:
SP15:
SP16: - - - -
SP17:
SP18:
SP19:
SP20:
SP21: - -
SP22:
SP23:
SP24:
SP25:
SP26:

Relevant External Links for SPTAN1 Gene

GeneLoc Exon Structure for
SPTAN1
ECgene alternative splicing isoforms for
SPTAN1

Expression for SPTAN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPTAN1 Gene

Protein differential expression in normal tissues from HIPED for SPTAN1 Gene

This gene is overexpressed in Spinal cord (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SPTAN1 Gene



Protein tissue co-expression partners for SPTAN1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SPTAN1 Gene:

SPTAN1

SOURCE GeneReport for Unigene cluster for SPTAN1 Gene:

Hs.372331

Evidence on tissue expression from TISSUES for SPTAN1 Gene

  • Heart(5)
  • Liver(5)
  • Nervous system(5)
  • Lung(4.8)
  • Kidney(3.9)
  • Adrenal gland(3.8)
  • Intestine(3.7)
  • Eye(3.6)
  • Gall bladder(3.6)
  • Blood(2.7)
  • Pancreas(2.7)
  • Muscle(2.4)
  • Skin(2.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for SPTAN1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • integumentary
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Organs:
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • eye
  • face
  • forehead
  • head
  • lip
  • mouth
  • nose
  • pharynx
  • skull
Thorax:
  • chest wall
  • diaphragm
  • esophagus
  • lung
  • rib
  • rib cage
Abdomen:
  • abdominal wall
  • intestine
  • large intestine
  • stomach
Pelvis:
  • pelvis
  • rectum
Limb:
  • digit
  • finger
  • foot
  • hand
  • lower limb
  • upper limb
General:
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal column
  • spinal cord
  • vertebrae
genes like me logo Genes that share expression patterns with SPTAN1: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SPTAN1 Gene

Orthologs for SPTAN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPTAN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPTAN1 34 35
  • 99.61 (n)
oppossum
(Monodelphis domestica)
Mammalia SPTAN1 35
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPTAN1 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPTAN1 34 35
  • 90.54 (n)
cow
(Bos Taurus)
Mammalia SPTAN1 34 35
  • 90.04 (n)
mouse
(Mus musculus)
Mammalia Sptan1 34 16 35
  • 89.48 (n)
rat
(Rattus norvegicus)
Mammalia Sptan1 34
  • 89.28 (n)
chicken
(Gallus gallus)
Aves SPTAN1 34 35
  • 82.9 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia sptan1 34
  • 80.01 (n)
Str.817 34
African clawed frog
(Xenopus laevis)
Amphibia sptan1-A 34
zebrafish
(Danio rerio)
Actinopterygii spna2 34 35
  • 79.91 (n)
wufa20e05 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.415 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006686 34
  • 65.07 (n)
fruit fly
(Drosophila melanogaster)
Insecta alpha-Spec 36 34 35
  • 64.58 (n)
worm
(Caenorhabditis elegans)
Secernentea spc-1 36 34 35
  • 60.37 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 72 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11232 34
Species where no ortholog for SPTAN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SPTAN1 Gene

ENSEMBL:
Gene Tree for SPTAN1 (if available)
TreeFam:
Gene Tree for SPTAN1 (if available)

Paralogs for SPTAN1 Gene

(14) SIMAP similar genes for SPTAN1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for SPTAN1 Gene

genes like me logo Genes that share paralogs with SPTAN1: view

Variants for SPTAN1 Gene

Sequence variations from dbSNP and Humsavar for SPTAN1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_035454 A breast cancer sample
VAR_035455 A breast cancer sample
VAR_035456 A breast cancer sample
VAR_035457 A breast cancer sample
rs398122865 Pathogenic 128,627,414(+) GGAAC(-/AGC)GGCGG cds-indel

Structural Variations from Database of Genomic Variants (DGV) for SPTAN1 Gene

Variant ID Type Subtype PubMed ID
esv2666546 CNV deletion 23128226
esv2739074 CNV deletion 23290073
esv3423649 CNV insertion 20981092
esv3621811 CNV loss 21293372
nsv1044853 CNV gain 25217958
nsv1051081 CNV gain 25217958
nsv416781 CNV deletion 16902084
nsv526979 CNV gain 19592680

Variation tolerance for SPTAN1 Gene

Residual Variation Intolerance Score: 0.277% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.21; 39.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPTAN1 Gene

Human Gene Mutation Database (HGMD)
SPTAN1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPTAN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPTAN1 Gene

Disorders for SPTAN1 Gene

MalaCards: The human disease database

(13) MalaCards diseases for SPTAN1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
epileptic encephalopathy, early infantile, 5
  • eiee5
west syndrome
  • epileptic encephalopathy, early infantile, 1
sjogren's syndrome
  • sicca syndrome
spastic quadriplegia
  • quadriplegic infantile cerebral palsy
quadriplegia
  • tetraplegia
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

SPTN1_HUMAN
  • Epileptic encephalopathy, early infantile, 5 (EIEE5) [MIM:613477]: A disorder characterized by seizures associated with hypsarrhythmia, profound mental retardation with lack of visual attention and speech development, as well as spastic quadriplegia. {ECO:0000269 PubMed:20493457}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SPTAN1

Genetic Association Database (GAD)
SPTAN1
Human Genome Epidemiology (HuGE) Navigator
SPTAN1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPTAN1
genes like me logo Genes that share disorders with SPTAN1: view

No data available for Genatlas for SPTAN1 Gene

Publications for SPTAN1 Gene

  1. Brain and muscle express a unique alternative transcript of alphaII spectrin. (PMID: 10625438) Cianci C.D. … Morrow J.S. (Biochemistry 1999) 3 4 22 64
  2. Site-directed mutagenesis of alpha II spectrin at codon 1175 modulates its mu-calpain susceptibility. (PMID: 8993318) Stabach P.R. … Morrow J.S. (Biochemistry 1997) 3 4 22 64
  3. Generation of diversity in nonerythroid spectrins. Multiple polypeptides are predicted by sequence analysis of cDNAs encompassing the coding region of human nonerythroid alpha-spectrin. (PMID: 2307671) Moon R.T. … McMahon A.P. (J. Biol. Chem. 1990) 3 4 22 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64

Products for SPTAN1 Gene

  • Cyagen custom Knockout/knockin (KOKI) mouse models for SPTAN1
  • Cyagen custom CRISPR mouse